Efudix

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Water-in-oil submicron emulsions were used as carrier for the topical delivery of 5-fluorouracil (5FU). The effect of components such as level and hydrophilic-lipophilic balance (HLB) value of surfactant, type of cosurfactant, and drug concentration on the delivery capability of drug in the receptor fluid and in the various skin layers (stratum corneum, epidermis and dermis) were evaluated. The result showed the submicron emulsion could increase the transdermal and deposition of 5FU compared with the aqueous control...

BACKGROUND: Darier's disease, an autosomal dominant disorder, is often resistant to therapy. There have been few encouraging reports in recent years of treatment using topical 5-fluorouracil (5FU) in this indication. We describe three cases of Darier's disease treated with Efudix: though it initially proved very effective, after several months this treatment became inefficacious. PATIENTS AND METHODS: Case 1: a 16-year-old girl with Darier's disease refractory to conventional treatments...

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BACKGROUND: Darier's disease is an inherited genodermatosis with autosomal dominant transmission characterized by hyperkeratotic papules of seborrheic regions in the axillae, groin or submammary skin in women. Current therapeutic alternatives are poor, encouraging recourse to alternatives treatments such as topical 5-fluorouracil (Efudix) used until now for pre-epitheliomatous keratosis. CASE REPORT: A 55-year-old man presenting severe Darier's disease refractory to therapy for more than twenty years was treated with topical 5-fluorouracil...

BACKGROUND: Topical 5-fluorouracil (5-FU) cream is widely used in the treatment of actinic keratoses (AKs) but the optimum treatment regimen that provides efficacy while minimizing side-effects remains unclear. OBJECTIVES: A randomized trial to compare the efficacy and side-effects of daily vs. weekly application of 5% 5-FU in the treatment of AKs of the scalp and face. PATIENTS/METHODS: Twenty patients were recruited and randomized to two groups...

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OBJECTIVE: To revise clinical histological, therapeutic and evolutive specifications of Bowen's disease. To emphasise the importance of an early diagnosis and to promote treatment with topical 5-fluorouracil by the family doctor. DESIGN: Descriptive and transversal study. SETTING: Outpatient and dermatology departments in a hospital in the metropolitan area of Madrid. PATIENTS AND OTHER PARTICIPANTS: Nine patients (5 male and 4 female), aged over 50, with slightly pigmented skin and diagnosed to have Bowen's disease...

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Repigmentation has been observed under the influence of topically administered Efudix cream in 3 patients with vitiligo of symmetrical acral type. No response has been received in 2 patients with segmental vitiligo treated in the same way. Recurrence of vitiligo was seen in 1 patient. Histologic and electron microscopic characterization of recolonized melanocytes is described. The significance of topical 5-fluorouracil treatment in vitiligo is discussed.

The effectiveness of 5-fluorouracil (Efudix) in the treatment of vaginal intraepithelial neoplasia was assessed in 14 patients diagnosed with the condition between January 1980 and December 1982. All patients received a standard dose of 2.5 g 5-fluorouracil cream once weekly for at least 10 consecutive weeks; mean duration of treatment was 12 weeks (range 10-20 weeks). The vaginal lesion was associated with a major dysplastic lesion of the cervix in all patients. The duration of follow-up ranged from 4 to 42 months (mean 15 months)...

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The results of the local application of 5-fluorouracil in the form of cream ("Efudix" Roche) in the therapy of senile keratoses and basocellular carcinomas were presented in this paper. A total of 205 changes of senile keratoses and 27 changes of basocellular carcinomas were treated in 90 patients. The cream was put on changes of senile keratoses without covering two times daily during a three--week period on the average up to the appearance of erosion. In cases of basaloma the cream was administered in the form of occlusive bandage with the duration of six hours each day...

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