Vinu Krishnan, Kevin Peng, Apoorva Sarode, Supriya Prakash, Zongmin Zhao, Sergey K Filippov, Kristina Todorova, Brittney R Sell, Omar Lujano, Shirin Bakre, Anusha Pusuluri, Douglas Vogus, Kenneth Y Tsai, Anna Mandinova, Samir Mitragotri
Skin cancer is one of the most common types of cancer in the United States and worldwide. Topical products are effective for treating cancerous skin lesions when surgery is not feasible. However, current topical products induce severe irritation, light-sensitivity, burning, scaling, and inflammation. Using hyaluronic acid (HA), we engineered clinically translatable polymer-drug conjugates of doxorubicin and camptothecin termed, DOxorubicin and Camptothecin Tailored at Optimal Ratios (DOCTOR) for topical treatment of skin cancers...
June 2021: Science Advances