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Ingenol disoxate

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https://www.readbyqxmd.com/read/27503482/ingenol-disoxate-a-novel-4-isoxazolecarboxylate-ester-of-ingenol-with-improved-properties-for-treatment-of-actinic-keratosis-and-other-non-melanoma-skin-cancers
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Malene Bertelsen, Martin Stahlhut, Gunnar Grue-Sørensen, Xifu Liang, Gitte Bach Christensen, Kresten Skak, Karen Margrethe Engell, Thomas Högberg
INTRODUCTION: Ingenol mebutate gel (Picato(®), LEO Pharma A/S) is approved for the field treatment of actinic keratosis and is characterized by high sustained clearance of actinic lesions. The inherent propensity of ingenol mebutate towards chemical rearrangement necessitates refrigeration of the final product. We sought to identify novel ingenol derivatives with enhanced chemical stability and similar or improved in vitro potency and in vivo efficacy. METHODS: A number of ingenol esters were synthesized with full regiocontrol from ingenol...
December 2016: Dermatology and Therapy
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