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https://www.readbyqxmd.com/read/27752180/-panuveitis-with-oral-and-genital-ulcer-misdiagnosed-as-behcet-s-disease-two-cases-report-and-literature-review
#1
Y Wang, L Yang, Z L Zhang
Here we reported two patients who presented with panuveitis and were transferred from ophthalmologists to rheumatologists, for both the patients had oral and genital ulcers. They were misdiagnosed with Behcet's disease at first glance. Two young males presented with acute uveitis with history of recurrent oral and genital ulcers. They initially presented with symptoms and signs resembling Behcet's disease and were treated with systemic steroids with suboptimal responses. Routine laboratory test revealed syphilis and human immunodeficiency virus (HIV) infection...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27729756/non-human-immunodeficiency-virus-related-ocular-syphilis-in-a-korean-population-clinical-manifestations-and-treatment-outcomes
#2
Yonguk Kim, Seung-Young Yu, Hyung Woo Kwak
PURPOSE: To describe the clinical manifestations and treatment outcomes of ocular syphilis in patients without human immunodeficiency virus (HIV) infection. METHODS: A total of 45 eyes from 39 patients with ocular syphilis confirmed by serologic tests were reviewed retrospectively. The included cases were all non-HIV-infected patients presenting with intraocular inflammation from 2002 to 2014 at Kyung Hee University Hospital. Medical records of 45 eyes were analyzed and included best-corrected visual acuity and ophthalmologic examination findings of the anterior and posterior segments to determine the focus of inflammation...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27230575/herpes-simplex-acute-retinal-necrosis-presenting-as-unilateral-disc-swelling-in-young-immunocompetent-patients
#3
Yan Tong Koh, Bryan Chin-Hou Ang, Su Ling Ho, Stephen Charn Beng Teoh, Rupesh Agrawal
PURPOSE: To report two cases of young immunocompetent males with herpes simplex acute retinal necrosis (HSV ARN) with initial diagnosis of unilateral disc swelling. METHODS: Retrospective case series. RESULTS: Two young immunocompetent males who were diagnosed to have unilateral disc swelling were treated as presumed optic neuritis and started on systemic steroids. On dilated fundal examination, unilateral retinitis and vasculitis was found after 2-3 days of systemic steroids and the diagnosis of ARN was made...
May 26, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/26868532/optic-neuropathy-secondary-to-syphilis-in-an-hiv-negative-patient
#4
C Berrozpe-Villabona, E Santos-Bueso, P Bañeros-Rojas, S Aguilar Munoa, F Saenz-Francés, D Díaz-Valle, J M Martínez-de-la-Casa, J García-Feijoo
Ocular syphilis is a resurgent clinical condition due to unsafe sexual practices. It has been reported in both immunocompromised and immunocompetent patients, but in HIV positive patients, it is more likely to exhibit a more aggressive course and adopt atypical clinical patterns such as optic nerve involvement. Herein we report an atypical case of optic neuritis secondary to syphilis in an HIV negative patient. This case highlights the importance of considering syphilis in the differential diagnosis of ocular inflammation and of obtaining HIV serology, since both diseases share common risk factors...
February 2016: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/26730177/clinical-and-laboratory-characteristics-of-ocular-syphilis-co-infection-and-therapy-response
#5
Ozlem Sahin, Alireza Ziaei
PURPOSE: To describe the clinical presentation of patients diagnosed with presumed latent ocular syphilis and congenital ocular syphilis at tertiary referral center in Turkey, and to compare the clinical findings with patients described in other studies, specifically focusing on demographics and co-infections. METHODS: This is a retrospective study reviewing the medical records of patients diagnosed with ocular inflammation between January 2012 and June 2014 at a tertiary referral center in Turkey...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26693768/-ocular-manifestations-of-syphilitic-uveoretinitis-in-patients-co-infected-with-human-immunodeficiency-virus
#6
Rui Zhang, Jiang Qian, Zhujian Wang, Yifei Yuan
OBJECTIVE: To investigate the clinical manifestations of syphilitic uveoretinitis in patients co-infected with human immunodeficiency virus (HIV). METHODS: Uveoretinitis patients presenting between January 2008 and December 2014 at Eye and ENT Hospital of Fudan University were collected. Patients were selected with positive serologic tests, including rapid plasma regain titer (RPR) > 1:8, treponema pallidum particle agglutination assay (TPPA) and human immunodeficiency virus (HIV)...
October 2015: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/25801686/multiple-sclerosis-and-hiv-1-infection-case-report-of-a-hiv-controller
#7
Jerome H Chin
Multiple sclerosis (MS) has been infrequently described in association with human immunodeficiency virus (HIV) infection. Underreporting, missed diagnoses or a true negative association between MS and HIV infection are all possible explanations for the paucity of published cases. Since MS involves inflammation and demyelination of the central nervous system by autoreactive T cells, immunosuppression caused by HIV infection would be expected to confer a reduced risk of MS. This report describes a case of relapsing-remitting MS in a woman with non-progressive HIV-1 infection for 5 years...
August 2015: Journal of Neurovirology
https://www.readbyqxmd.com/read/25788666/syphilitic-uveitis-and-optic-neuritis-in-sydney-australia
#8
Luke C Northey, Simon E Skalicky, Avinash Gurbaxani, Peter J McCluskey
AIMS: To describe ocular syphilis presentations to a tertiary referral eye hospital over a 5-year period and to document HIV coinfection frequency. METHODS: A retrospective chart review was conducted of consecutive ocular syphilis presentations to Sydney Eye Hospital from 2007 to 2012. Inclusion criteria were positive syphilis serology, ocular inflammation on clinical examination and appropriate syphilis treatment. Outcome measures were clinical features at presentation and best-corrected visual acuity (BCVA) at interval follow-up...
September 2015: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/25284106/neuro-ophthalmic-presentations-and-treatment-of-cryptococcal-meningitis-related-increased-intracranial-pressure
#9
Angelina Espino Barros Palau, Michael L Morgan, Rod Foroozan, Andrew G Lee
OBJECTIVE: To illustrate three different ophthalmic presentations of cryptococcal meningitis (CM). INTRODUCTION: CM is the most common manifestation of extra-pulmonary cryptococcosis. Intracranial hypertension occurs in up to 75% of patients with CM and is associated with increased mortality. CM can present to the ophthalmologist as vision loss, papilledema, abducens palsy, and/or other cranial neuropathies. PARTICIPANTS AND METHODS: We report three cases, two C...
October 2014: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/25190339/-clinical-and-therapeutic-differences-in-neuro-ophthalmological-involvement-secondary-to-syphilis
#10
J A Crespo-Burillo, D Gil-Perez, R Alarcia-Alejos, N Hernando-Quintana, S Garcia-Rubio, J Martin-Martinez
INTRODUCTION. There are many forms of neuro-ophthalmological involvement secondary to syphilis, and not all of them are well known. Our aim is to determine the clinical and therapeutic differences in these patients. CASE REPORTS. Our sample included eight patients diagnosed with an ocular and neuro-ophthalmological disorder due to syphilis over the years 2012 and 2013. Five of them presented uveitis, pan-eveitis being the most frequent, with three cases. Two cases presented papilloedema and another displayed retrobulbar optic neuropathy...
September 16, 2014: Revista de Neurologia
https://www.readbyqxmd.com/read/24880727/sudden-onset-bilateral-deafness-revealing-early-neurosyphilis
#11
A-L Cassilde, G Barnaud, S Baccar, E Mortier
INTRODUCTION: Rapid-onset of sensorineural hearing loss in a patient at risk of genital or oral exposure to treponema can be secondary to early neurosyphilis, for which delayed treatment may result in irreversible sequelae. SUMMARY OF THE CASE REPORT: A 40-year-old, HIV seropositive man with a CD4 lymphocyte count greater than 500/mm(3) presented with rapid-onset of bilateral sensorineural hearing loss over a period of one week. Otorhinolaryngological examination was normal...
December 2014: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/24655791/-ocular-syphilis
#12
REVIEW
C Chiquet, H Khayi, C Puech, M Tonini, P Pavese, F Aptel, J-P Romanet
Syphilis is a sexually transmitted disease caused by Treponema pallidum. Previously known as the "great imitator", this disease can have numerous and complex manifestations. The ophthalmologist should suspect the diagnosis in patients with uveitis or optic neuropathy and high-risk sexual behavior and/or another sexually transmitted disease (such as HIV) or those presenting with posterior placoid chorioretinitis or necrotising retinitis. Ocular involvement in acquired syphilis is rare, tending to occur during the secondary and tertiary stages of the disease...
April 2014: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/24575260/hematologic-manifestations-in-a-child-with-hiv-a-case-report
#13
Sh Osiya, F Binesh, F Ferdosian, M Shakiba
BACKGROUND: Immune deficiency in human might be primary or secondary and could be seen with a wide variety of manifestations. In the following, we presented a Child with various complains that diagnosed to have HIV infection. CASE REPORT: A 2/5 y/o child was admitted to the hospital for FUO with prolonged cough, FTT, cervical lymphadenopathy, hepatosplenomegaly and bilateral optic neuritis. . He was hospitalized for fever, cytopenia and hepatosplenomegaly one year ago, and three months later in an outpatient visit, these signs improved, except thrombocytopenia...
2012: Iranian Journal of Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/23747673/-signification-of-epstein-barr-virus-detection-in-the-cerebrospinal-fluid-of-a-patient-with-human-immunodeficiency-virus-related-burkitt-lymphoma
#14
Selim Jennane, El Mehdi Mahtat, Johanna Konopacki, Vincent Foissaud, Bertrand Souleau, Jean Valère Malfuson, Thierry De Revel
The significance of Epstein-Barr virus detection in the cerebrospinal fluid of patients with Burkitt lymphoma is poorly studied. We report the case of a patient with immunodeficiency associated Burkitt lymphoma in complete remission who presented 5 months after the end of treatment, an isolated optic neuritis. Lumbar puncture found lymphocytic meningitis and the viral load of Epstein-Barr virus was 234,000 copies per milliliter in the cerebrospinal fluid. These symptoms could be explained by Epstein-Barr virus meningoencephalitis but the detection of MYC rearrangements in the cerebrospinal fluid confirms the diagnosis of Burkitt lymphoma cerebral relapse...
May 2013: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/23569976/bilateral-atypical-optic-neuritis-associated-with-tuberculosis-in-an-immunocompromised-patient
#15
Juanarita Jaafar, Wan Hazabbah Wan Hitam, Raja Azmi Mohd Noor
A 27 year-old lady, presented with sudden loss of vision in the right eye for a week. It was followed by poor vision in the left eye after 3 days. It involved the whole entire visual field and was associated with pain on eye movement. She was diagnosed to have miliary tuberculosis and retroviral disease 4 months ago. She was started on anti-TB since then but defaulted highly active anti-retroviral therapy (HAART). On examination, her visual acuity was no perception of light in the right eye and 6/120 (pinhole 3/60) in the left eye...
July 2012: Asian Pacific Journal of Tropical Biomedicine
https://www.readbyqxmd.com/read/23514319/simultaneous-optic-and-vestibulocochlear-syphilitic-neuropathy-in-a-patient-with-hiv-infection
#16
Ignacio Rodríguez-Uña, Mercedes Serrador-García, Enrique Santos-Bueso, David Díaz-Valle, Julián García-Feijóo
BACKGROUND: The purpose of this report is to present a case of optic and vestibulocochlear neuropathy as a manifestation of concurrent HIV and syphilis coinfection. This is an interventional case report of a 37-year-old man who complained of blurry central vision in his left eye and hearing loss in his left ear over the past 2 weeks. FINDINGS: Visual acuity was 20/20 in both eyes, and the anterior segment was normal in both eyes without relative afferent pupillary defect...
2013: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/23285220/early-clinical-and-subclinical-visual-evoked-potential-and-humphrey-s-visual-field-defects-in-cryptococcal-meningitis
#17
Anand Moodley, William Rae, Ahmed Bhigjee, Cathy Connolly, Natasha Devparsad, Andrew Michowicz, Thomas Harrison, Angela Loyse
Cryptococcal induced visual loss is a devastating complication in survivors of cryptococcal meningitis (CM). Early detection is paramount in prevention and treatment. Subclinical optic nerve dysfunction in CM has not hitherto been investigated by electrophysiological means. We undertook a prospective study on 90 HIV sero-positive patients with culture confirmed CM. Seventy-four patients underwent visual evoked potential (VEP) testing and 47 patients underwent Humphrey's visual field (HVF) testing. Decreased best corrected visual acuity (BCVA) was detected in 46...
2012: PloS One
https://www.readbyqxmd.com/read/21750970/posterior-syphilitic-uveitis-clinical-characteristics-co-infection-with-hiv-response-to-treatment
#18
Sing Your Li, Andrea D Birnbaum, Howard H Tessler, Debra A Goldstein
PURPOSE: To describe the characteristics and clinical course of patients with active posterior syphilitic uveitis evaluated between 1991 and 2009. METHODS: Retrospective chart review. RESULTS: Thirteen patients with active posterior syphilitic uveitis were identified at a single institution. All were men, and all with available data were men having sex with men (MSM). Ten of 12 (83%) with available data were HIV positive. Four (31%) had a history of syphilis...
September 2011: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/21731332/herpes-zoster-ophthalmicus-disease-spectrum-in-young-adults
#19
Noopur Gupta, Ritika Sachdev, Rajesh Sinha, Jeewan S Titiyal, Radhika Tandon
PURPOSE: To establish the clinical profile of herpes zoster ophthalmicus (HZO) in adults younger than 40 years and correlate the clinical manifestation with their immune status. MATERIALS AND METHODS: A retrospective chart review was performed of patients younger than 40 years who presented with HZO. Data were collected on demographics, medical history, clinical presentation, results of serological investigations, and visual outcome. RESULTS: The study cohort comprised 18 subjects with a mean age of 29...
April 2011: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/21573818/expanding-the-spectrum-of-neurological-disease-associated-with-epstein-barr-virus-activity
#20
M Kleines, J Schiefer, A Stienen, M Blaum, K Ritter, M Häusler
The purpose of this study was to delineate the spectrum of neurological diseases attributed to Epstein-Barr virus (EBV) activity. The approach was a retrospective study on patients with EBV activity proven by a positive EBV antibody-specific index (AI) and/or cerebrospinal fluid (CSF) PCR. One hundred six children and adults (AI positive = 77, AI + PCR positive = 3, PCR positive = 26) were identified, most with reactivated infections. Twenty-eight showed typical EBV-related diseases (encephalitis, neuritis, meningitis), 19 further infections (HSV encephalitis, neuroborreliosis, HIV infection, bacterial meningitis), nine immune-mediated disorders (multiple sclerosis, optic neuritis), and 50 further diseases not typical for EBV...
December 2011: European Journal of Clinical Microbiology & Infectious Diseases
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