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https://www.readbyqxmd.com/read/28339472/vector-status-of-aedes-species-determines-geographical-risk-of-autochthonous-zika-virus-establishment
#1
Lauren Gardner, Nan Chen, Sahotra Sarkar
BACKGROUND: The 2015-16 Zika virus pandemic originating in Latin America led to predictions of a catastrophic global spread of the disease. Since the current outbreak began in Brazil in May 2015 local transmission of Zika has been reported in over 60 countries and territories, with over 750 thousand confirmed and suspected cases. As a result of its range expansion attention has focused on possible modes of transmission, of which the arthropod vector-based disease spread cycle involving Aedes species is believed to be the most important...
March 24, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28338754/spatial-quantification-of-the-world-population-potentially-exposed-to-zika-virus
#2
Alberto J Alaniz, Antonella Bacigalupo, Pedro E Cattan
Background: Zika virus is an emerging Flaviviridae virus, which has spread rapidly in the last few years. It has raised concern because it has been associated with fetus microcephaly when pregnant women are infected. The main vector is the mosquito Aedes aegypti , distributed in tropical areas. Methods: Niche modelling techniques were used to estimate the potential distribution area of A. aegypti. This was overlapped with human population density, determining areas of potential transmission risk worldwide...
February 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28337406/the-influence-of-health-concern-on-travel-plans-with-focus-on-the-zika-virus-in-2016
#3
Nicole J Olynk Widmar, S R Dominick, Audrey Ruple, Wallace E Tyner
Tourists consider many factors, including health, when choosing travel destinations. The potential for exposure to novel or foreign diseases alone can deter travelers from selecting high-risk locations for disease transmission. The 2015-2016 Zika Virus (ZIKV) outbreak in the Americas and Caribbean prompted the World Health Organization (WHO) to declare a Public Health Emergency of International Concern. This study investigated factors that may contribute to travel avoidance to areas experiencing ZIKV transmission while also considering different levels of health concern and awareness among groups with varying demographics...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28336600/complete-genome-sequences-before-and-after-mammalian-cell-culture-of-zika-virus-isolated-from-the-serum-of-a-symptomatic-male-patient-from-oaxaca-mexico
#4
Celia Boukadida, Jesús M Torres-Flores, Martha Yocupicio-Monroy, Elvira Piten-Isidro, Amaranta Y Rivero-Arrieta, Yara A Luna-Villalobos, Liliane Martínez-Vargas, Sofía L Alcaraz-Estrada, Klintsy J Torres, Rosalia Lira, Gustavo Reyes-Terán, Edgar E Sevilla-Reyes
Zika virus (ZIKV) is an emerging arthropod-borne flavivirus associated with severe congenital malformations and neurological complications. Although the ZIKV genome is well characterized, there is limited information regarding changes after cell isolation and culture adaptation. We isolated, and passaged in Vero cells, ZIKV from the serum of a symptomatic male patient and compared the viral genomes before and after culture. Single nucleotide polymorphisms were characteristic among serum-circulating genomes, while such diversity decreased after cell culture...
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28333986/building-the-road-to-a-regional-zoonoses-strategy-a-survey-of-zoonoses-programmes-in-the-americas
#5
Melody J Maxwell, Mary H Freire de Carvalho, Armando E Hoet, Marco A N Vigilato, Julio C Pompei, Ottorino Cosivi, Victor J Del Rio Vilas
BACKGROUND: In recent years, global public health security has been threatened by zoonotic disease emergence as exemplified by outbreaks of H5N1 and H1N1 influenza, SARS, and most recently Ebola and Zika. Additionally, endemic zoonoses, such as rabies, burden countries year after year, placing demands on limited finances and personnel. To survey the baseline status of the emerging and endemic zoonoses programmes of the Latin American and the Caribbean (LAC) countries, the Pan American Health Organization (PAHO) conducted a survey of priority emerging and endemic zoonoses, countries´ prioritization criteria and methodologies, and suggestions to strengthen countries capacities and regional approaches to zoonoses control...
2017: PloS One
https://www.readbyqxmd.com/read/28331858/zika-virus-an-emerging-epidemic
#6
EDITORIAL
Anna Ratanacharoensiri, Luke Huggins, Mark Johnson, Isha Patel
No abstract text is available yet for this article.
January 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28330900/adaptive-immune-responses-to-zika-virus-are-important-for-controlling-virus-infection-and-preventing-infection-in-brain-and-testes
#7
Clayton W Winkler, Lara M Myers, Tyson A Woods, Ronald J Messer, Aaron B Carmody, Kristin L McNally, Dana P Scott, Kim J Hasenkrug, Sonja M Best, Karin E Peterson
The recent association between Zika virus (ZIKV) and neurologic complications, including Guillain-Barré syndrome in adults and CNS abnormalities in fetuses, highlights the importance in understanding the immunological mechanisms controlling this emerging infection. Studies have indicated that ZIKV evades the human type I IFN response, suggesting a role for the adaptive immune response in resolving infection. However, the inability of ZIKV to antagonize the mouse IFN response renders the virus highly susceptible to circulating IFN in murine models...
March 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28325921/zika-virus-genome-biology-and-molecular-pathogenesis
#8
REVIEW
Anyou Wang, Stephanie Thurmond, Leonel Islas, Kingyung Hui, Rong Hai
Zika virus (ZIKV) is an emerging RNA virus in the widespread Flavivirus genus. Recently, ZIKV has rapidly spread around the world and has been implicated in human disease, including neurological disorders, triggering public and scientific attention. Understanding how ZIKV causes disease is the highest priority, yet little is known about this virus. Here we examine the currently published data from ZIKV studies to provide the latest understanding of ZIKV genome biology and molecular pathogenesis. The ZIKV genome evolved rapidly from the Flavivirus genus and diverged from the members of this genus, even within the dengue virus cluster to which ZIKV belongs...
March 22, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28318966/structural-biology-of-the-zika-virus
#9
REVIEW
Yi Shi, George F Gao
Zika virus (ZIKV), a Flaviviridae family member transmitted to humans by mosquitoes, has emerged as a major health concern. ZIKV infections can cause serious neurological complications in adults, and infection in pregnant women can cause congenital malformations, including fetal and newborn microcephaly. In response to this emerging concern, the structural virology field was quick to explore the features of ZIKV. These efforts have provided significant insights into ZIKV pathogenesis, and have identified targets for drug design...
March 15, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/28316896/vector-competence-of-anopheles-and-culex-mosquitoes-for-zika-virus
#10
Brittany L Dodson, Jason L Rasgon
Zika virus is a newly emergent mosquito-borne flavivirus that has caused recent large outbreaks in the new world, leading to dramatic increases in serious disease pathology including Guillain-Barre syndrome, newborn microcephaly, and infant brain damage. Although Aedes mosquitoes are thought to be the primary mosquito species driving infection, the virus has been isolated from dozens of mosquito species, including Culex and Anopheles species, and we lack a thorough understanding of which mosquito species to target for vector control...
2017: PeerJ
https://www.readbyqxmd.com/read/28298448/evaluation-of-altona-diagnostics-realstar-zika-virus-rt-pcr-test-kit-for-zika-virus-pcr-testing
#11
Arnaud G L'Huillier, Ernesto Lombos, Elaine Tang, Stephen Perusini, Alireza Eshaghi, Sandeep Nagra, Christine Frantz, Romy Olsha, Erik Kristjanson, Kristina Dimitrova, David Safronetz, Mike Drebot, Jonathan B Gubbay
Background: With the emerging ZIKA virus (ZIKV) epidemic, accessible real-time reverse-transcription PCR (rRT-PCR) assays are needed to streamline testing. The commercial Altona Diagnostics RealStar ZIKV rRT-PCR Test Kit has been approved for Emergency Use Authorization by the FDA. Our aim was to verify Altona-PCR, by comparing it to the CDC-designed dual target ZIKV virus rRT-PCR reference assay (Reference-PCR), and describe demographics of patients tested for ZIKV by rRT-PCR in Ontario, Canada.Methods: A large set of clinical specimens were tested for ZIKV by Altona-PCR and Reference-PCR...
March 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28293228/prevention-and-control-strategies-to-counter-zika-epidemic
#12
REVIEW
Irfan A Rather, Sanjay Kumar, Vivek K Bajpai, Jeongheui Lim, Yong-Ha Park
ZIKA virus (ZIKA) has now become a global phenomenon. Since 2007, evidence of ZIKA transmission has been reported over 72 countries and territories. The transmission of ZIKA has made World Health Organization to categorize the situation under the ambit of a health emergency. This situation is serious because there appears to be a highly tangible link between infection during pregnancy and the occurrence of microcephaly and Guillain-Barré syndrome. In the context of this emergency situation, this review article intends to discuss the prevention and control strategies such as avoiding travel to infected area, being careful from mosquito bites, take precautions to reduce the risk of sexual transmission, and seek medical care for any acute illness with rash or fever...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28292840/using-brain-organoids-to-understand-zika-virus-induced-microcephaly
#13
Xuyu Qian, Ha Nam Nguyen, Fadi Jacob, Hongjun Song, Guo-Li Ming
Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble in vivo organs are pushing the frontiers of human disease modeling and drug development. In response to the global health emergency posed by the Zika virus (ZIKV) outbreak, brain organoids engineered to mimic the developing human fetal brain have been employed to model ZIKV-induced microcephaly. Here, we discuss the advantages of brain organoids over other model systems to study development and highlight recent advances in understanding ZIKV pathophysiology and its underlying pathogenesis mechanisms...
March 15, 2017: Development
https://www.readbyqxmd.com/read/28289727/seroprevalence-of-zika-virus-in-wild-african-green-monkeys-and-baboons
#14
Connor R Buechler, Adam L Bailey, Andrea M Weiler, Gabrielle L Barry, Meghan E Breitbach, Laurel M Stewart, Anna J Jasinska, Nelson B Freimer, Cristian Apetrei, Jane E Phillips-Conroy, Clifford J Jolly, Jeffrey Rogers, Thomas C Friedrich, David H O'Connor
Zika virus (ZIKV) has recently spread through the Americas and has been associated with a range of health effects, including birth defects in children born to women infected during pregnancy. Although the natural reservoir of ZIKV remains poorly defined, the virus was first identified in a captive "sentinel" macaque monkey in Africa in 1947. However, the virus has not been reported in humans or nonhuman primates (NHPs) in Africa outside Gabon in over a decade. Here, we examine ZIKV infection in 239 wild baboons and African green monkeys from South Africa, the Gambia, Tanzania, and Zambia using combinations of unbiased deep sequencing, quantitative reverse transcription-PCR (qRT-PCR), and an antibody capture assay that we optimized using serum collected from captive macaque monkeys exposed to ZIKV, dengue virus, and yellow fever virus...
March 2017: MSphere
https://www.readbyqxmd.com/read/28288355/time-required-to-initiate-outbreak-and-pandemic-observational-research
#15
Asgar H Rishu, Nicole Marinoff, Lisa Julien, Mariana Dumitrascu, Nicole Marten, Shauna Eggertson, Su Willems, Stacy Ruddell, Dane Lane, Bruce Light, Henry T Stelfox, Philippe Jouvet, Richard Hall, Steven Reynolds, Nick Daneman, Robert A Fowler
PURPOSE: Observational research focused upon emerging infectious diseases such as Ebola virus, Middle East respiratory syndrome, and Zika virus has been challenging to quickly initiate. We aimed to determine the duration of start-up procedures and barriers encountered for an observational study focused upon such infectious outbreaks. MATERIALS AND METHODS: At 1 pediatric and 5 adult intensive care units, we measured durations from protocol receipt to a variety of outbreak research milestones, including research ethics board (REB) approval, data sharing agreement (DSA) execution, and patient study screening initiation...
March 1, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28285789/zika-virus-history-epidemiology-transmission-and-clinical-presentation
#16
REVIEW
Byung-Hak Song, Sang-Im Yun, Michael Woolley, Young-Min Lee
Zika virus (ZIKV), a mosquito-borne positive-stranded RNA virus of the family Flaviviridae (genus Flavivirus), is now causing an unprecedented large-scale outbreak in the Americas. Historically, ZIKV spread eastward from equatorial Africa and Asia to the Pacific Islands during the late 2000s to early 2010s, invaded the Caribbean and Central and South America in 2015, and reached North America in 2016. Although ZIKV infection generally causes no symptoms or only a mild self-limiting illness, it has recently been linked to a rising number of severe neurological diseases, including microcephaly and Guillain-Barré syndrome...
March 3, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28281680/human-endometrial-stromal-cells-are-highly-permissive-to-productive-infection-by-zika-virus
#17
Isabel Pagani, Silvia Ghezzi, Adele Ulisse, Alicia Rubio, Filippo Turrini, Elisabetta Garavaglia, Massimo Candiani, Concetta Castilletti, Giuseppe Ippolito, Guido Poli, Vania Broccoli, Paola Panina-Bordignon, Elisa Vicenzi
Zika virus (ZIKV) is a recently re-emerged flavivirus transmitted to humans by mosquito bites but also from mother to fetus and by sexual intercourse. We here show that primary human endometrial stromal cells (HESC) are highly permissive to ZIKV infection and support its in vitro replication. ZIKV envelope expression was detected in the endoplasmic reticulum whereas double-stranded viral RNA colocalized with vimentin filaments to the perinuclear region. ZIKV productive infection also occurred in the human T-HESC cell line together with the induction of interferon-β (IFN-β) and of IFN-stimulated genes...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28279337/what-to-expect-when-you-re-expecting-zika
#18
Helen M Lazear
The 2015 emergence of Zika virus (ZIKV) in the Americas brought new attention to this previously obscure virus. Experimental model systems have been instrumental in rapidly advancing our understanding of ZIKV pathogenesis. Here, Lazear looks back on the events leading to the development of the ZIKV mouse model reported in Cell Host & Microbe.
March 8, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28278237/zika-virus-infection-of-rhesus-macaques-leads-to-viral-persistence-in-multiple-tissues
#19
Alec J Hirsch, Jessica L Smith, Nicole N Haese, Rebecca M Broeckel, Christopher J Parkins, Craig Kreklywich, Victor R DeFilippis, Michael Denton, Patricia P Smith, William B Messer, Lois M A Colgin, Rebecca M Ducore, Peta L Grigsby, Jon D Hennebold, Tonya Swanson, Alfred W Legasse, Michael K Axthelm, Rhonda MacAllister, Clayton A Wiley, Jay A Nelson, Daniel N Streblow
Zika virus (ZIKV), an emerging flavivirus, has recently spread explosively through the Western hemisphere. In addition to symptoms including fever, rash, arthralgia, and conjunctivitis, ZIKV infection of pregnant women can cause microcephaly and other developmental abnormalities in the fetus. We report herein the results of ZIKV infection of adult rhesus macaques. Following subcutaneous infection, animals developed transient plasma viremia and viruria from 1-7 days post infection (dpi) that was accompanied by the development of a rash, fever and conjunctivitis...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28278235/a-novel-zika-virus-mouse-model-reveals-strain-specific-differences-in-virus-pathogenesis-and-host-inflammatory-immune-responses
#20
Shashank Tripathi, Vinod R M T Balasubramaniam, Julia A Brown, Ignacio Mena, Alesha Grant, Susana V Bardina, Kevin Maringer, Megan C Schwarz, Ana M Maestre, Marion Sourisseau, Randy A Albrecht, Florian Krammer, Matthew J Evans, Ana Fernandez-Sesma, Jean K Lim, Adolfo García-Sastre
Zika virus (ZIKV) is a mosquito borne flavivirus, which was a neglected tropical pathogen until it emerged and spread across the Pacific Area and the Americas, causing large human outbreaks associated with fetal abnormalities and neurological disease in adults. The factors that contributed to the emergence, spread and change in pathogenesis of ZIKV are not understood. We previously reported that ZIKV evades cellular antiviral responses by targeting STAT2 for degradation in human cells. In this study, we demonstrate that Stat2-/- mice are highly susceptible to ZIKV infection, recapitulate virus spread to the central nervous system (CNS), gonads and other visceral organs, and display neurological symptoms...
March 9, 2017: PLoS Pathogens
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