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https://www.readbyqxmd.com/read/29777926/epidemiology-of-acute-febrile-illness-in-latin-america
#1
REVIEW
José Moreira, Clarisse S Bressan, Patricia Brasil, Andre M Siqueira
BACKGROUND: The causes of acute febrile illness (AFI) in Latin America (LA) are diverse and its complexity increase as the proportion of fever due to malaria decreases as control and new pathogens emerge in the region. In this context, it is important to shed light over the gaps on the epidemiological characteristics and the geographic range for many AFI aetiologies. AIMS: To review studies on community-acquired fever etiology other than malaria in LA, and to highlight knowledge gaps and challenges needing further investigation...
May 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29774519/zika-virus-baculovirus-expressed-virus-like-particles-induce-neutralizing-antibodies-in-mice
#2
Shiyu Dai, Tao Zhang, Yanfang Zhang, Hualin Wang, Fei Deng
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders. Several ZIKV vaccine candidates have been proposed, including inactivated and live attenuated virus vaccines, vector-based vaccines, DNA and RNA vaccines. These have been shown to be efficacious in preclinical studies in mice and nonhuman primates, but their use will potentially be a threat to immunocompromised individuals and pregnant women. Virus-like particles (VLPs) are empty particles composed merely of viral proteins, which can serve as a safe and valuable tool for clinical prevention and treatment strategies...
May 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29770095/zika-virus-where-to-from-here
#3
EDITORIAL
P K Muchaal
After the waves of reported cases of infection with Zika virus swept across the Americas in 2015-16, the overall transmission of the virus in the Western Hemisphere declined in 2017. Between June 8 and August 31, 2017, only 16 new cases of Zika virus infection, all travel-related, were reported in Canada. This represents an 88% reduction in the cases recorded during the same time frame in 2016. Herd immunity undoubtedly constrains the transmission of the virus in endemic regions. However, while most countries in the Americas are no longer observing continuous transmission in the form of sustained increases over time, some areas are experiencing a notable resurgence...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770094/travel-related-zika-virus-cases-in-canada-october-2015-june-2017
#4
J Tataryn, L Vrbova, M Drebot, H Wood, E Payne, S Connors, J Geduld, M German, K Khan, P A Buck
Background: Zika virus (ZIKV) is an emerging mosquito-borne disease that can cause severe birth defects if contracted congenitally. Since late 2015, there has been a large increase in the number of travel-related cases of Zika virus infection in Canada. Objective: The objective of this study was to describe the epidemiology of travel-related Zika cases in Canada from October 2015 to June 2017 and review them in the context of the international outbreak in the Americas...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29770047/emerging-infectious-diseases-prediction-and-detection
#5
N H Ogden, P AbdelMalik, Jrc Pulliam
Emerging infectious diseases (EIDs), including West Nile virus, severe acute respiratory syndrome (SARS) and Lyme disease, have had a direct effect within Canada, while many more EIDs such as Zika, chikungunya and Ebola are a threat to Canadians while travelling. Over 75% of EIDs affecting humans are, or were originally, zoonoses (infectious diseases transmitted from animals to humans). There are two main ways by which infectious diseases can emerge: by changes in their geographical ranges and by adaptive emergence, a genetic change in a microorganism that results in it becoming capable of invading a new niche, often by jumping to a new host species such as humans...
October 5, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769105/ornamental-bromeliads-of-miami-dade-county-florida-are-important-breeding-sites-for-aedes-aegypti-diptera-culicidae
#6
André B B Wilke, Chalmers Vasquez, Paul J Mauriello, John C Beier
BACKGROUND: A major public health concern is the emergence and geographical spread of vector-borne diseases such as Zika and yellow fever. Ornamental bromeliads retaining water in their leaf axils represent potential breeding sites for mosquitoes. As the role of ornamental bromeliads in breeding Aedes aegypti in Miami-Dade County, Florida is unknown, we hypothesize that ornamental bromeliads are important breeding sites for Ae. aegypti. Our objective was to survey bromeliads in areas with high densities of adult Ae...
May 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29768530/ns1-codon-usage-adaptation-to-humans-in-pandemic-zika-virus
#7
Caio César de Melo Freire, Giuseppe Palmisano, Carla T Braconi, Fernanda R Cugola, Fabiele B Russo, Patricia Cb Beltrão-Braga, Atila Iamarino, Daniel Ferreira de Lima Neto, Amadou Alpha Sall, Livia Rosa-Fernandes, Martin R Larsen, Paolo Marinho de Andrade Zanotto
BACKGROUND: Zika virus (ZIKV) was recognised as a zoonotic pathogen in Africa and southeastern Asia. Human infections were infrequently reported until 2007, when the first known epidemic occurred in Micronesia. After 2013, the Asian lineage of ZIKV spread along the Pacific Islands and Americas, causing severe outbreaks with millions of human infections. The recent human infections of ZIKV were also associated with severe complications, such as an increase in cases of Guillain-Barre syndrome and the emergence of congenital Zika syndrome...
May 10, 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29767504/motion-based-immunological-detection-of-zika-virus-using-pt-nanomotors-and-a-cellphone
#8
Mohamed Shehata Draz, Nivethitha Kota Lakshminaraasimulu, Sanchana Krishnakumar, Dheerendranath Battalapalli, Anish Vasan, Manoj Kumar Kanakasabapathy, Aparna Sreeram, Shantanu Kallakuri, Prudhvi Thirumalaraju, Yudong Li, Stephane Hua, Xu G Yu, Daniel R Kuritzkes, Hadi Shafiee
Zika virus (ZIKV) infection is an emerging pandemic threat to humans that can be fatal in newborns. Advances in digital health systems and nanoparticles can facilitate the development of sensitive and portable detection technologies for timely management of emerging viral infections. Here we report a nanomotor-based bead-motion cellphone (NBC) system for the immunological detection of ZIKV. The presence of virus in a testing sample results in the accumulation of platinum (Pt)-nanomotors on the surface of beads, causing their motion in H2 O2 solution...
May 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29761581/congenital-zika-syndrome-pitfalls-in-the-placental-barrier
#9
REVIEW
Nia Robinson, Evangelina E Mayorquin Galvan, Isidro G Zavala Trujillo, Maria G Zavala-Cerna
Much progress with respect to congenital Zika virus (ZIKV) pathogenesis has been achieved after the 2015 outbreak in Brazil. It is now accepted that ZIKV is vertically transmitted, infects cells of the developing central nervous system and the placenta, yet it is unclear to what extent placental affection contributes to the development of congenital ZIKV. The association between fulminant villitis and severe fetal involvement emerges as a possibility. ZIKV is unique among the Flaviviruses in its ability to be sexually transmitted, possibly responsible for its teratogenicity...
May 15, 2018: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29759076/threats-of-zika-virus-transmission-for-asia-and-its-hindu-kush-himalayan-region
#10
Meghnath Dhimal, Sushma Dahal, Mandira Lamichhane Dhimal, Shiva Raj Mishra, Khem B Karki, Krishna Kumar Aryal, Ubydul Haque, Md Iqbal Kabir, Pradeep Guin, Azeem Mehmood Butt, Harapan Harapan, Qi-Yong Liu, Cordia Chu, Doreen Montag, David Alexander Groneberg, Basu Dev Pandey, Ulrich Kuch, Ruth Müller
Asia and its Hindu Kush Himalayan (HKH) region is particularly vulnerable to environmental change, especially climate and land use changes further influenced by rapid population growth, high level of poverty and unsustainable development. Asia has been a hotspot of dengue fever and chikungunya mainly due to its dense human population, unplanned urbanization and poverty. In an urban cycle, dengue virus (DENV) and chikungunya virus (CHIKV) are transmitted by Aedes aegypti and Ae. albopictus mosquitoes which are also competent vectors of Zika virus (ZIKV)...
May 15, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29751200/biosensor-based-selective-detection-of-zika-virus-specific-antibodies-in-infected-individuals
#11
Gustavo Cabral-Miranda, Ana R Cardoso, Luis C S Ferreira, M Goreti F Sales, Martin F Bachmann
Zika virus (ZIKV) recently emerged as a global threat subsequent to its global spread because it induces microencephaly and other brain damages in infants born to infected mothers. Epidemiological monitoring of infection has been hampered by the absence of reliable serological tests capable to distinguish between ZIKV and other Flavivirus infections, in particular Dengue virus (DENV). As both viruses are transmitted by the same mosquito-species, their distributions largely overlap and reliable serological distinction between the viruses is essential...
May 1, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29747890/detection-and-prevention-of-perinatal-infection-cytomegalovirus-and-zika-virus
#12
REVIEW
Amber M Wood, Brenna L Hughes
Congenital cytomegalovirus is the most common viral congenital infection, and affects up to 2% of neonates. Significant sequelae may develop after congenital cytomegalovirus, including hearing loss, cognitive defects, seizures, and death. Zika virus is an emerging virus with perinatal implications; a congenital Zika virus syndrome has been identified, and includes findings such as microcephaly, fetal nervous system abnormalities, and neurologic sequelae after birth. Screening, diagnosis, prevention, and treatment of these perinatal infections are reviewed in this article...
June 2018: Clinics in Perinatology
https://www.readbyqxmd.com/read/29746833/rational-engineering-and-characterization-of-an-mab-that-neutralizes-zika-virus-by-targeting-a-mutationally-constrained-quaternary-epitope
#13
Kannan Tharakaraman, Satoru Watanabe, Kuan Rong Chan, Jia Huan, Vidya Subramanian, Yok Hian Chionh, Aditya Raguram, Devin Quinlan, Megan McBee, Eugenia Z Ong, Esther S Gan, Hwee Cheng Tan, Anu Tyagi, Shashi Bhushan, Julien Lescar, Subhash G Vasudevan, Eng Eong Ooi, Ram Sasisekharan
Following the recent emergence of Zika virus (ZIKV), many murine and human neutralizing anti-ZIKV antibodies have been reported. Given the risk of virus escape mutants, engineering antibodies that target mutationally constrained epitopes with therapeutically relevant potencies can be valuable for combating future outbreaks. Here, we applied computational methods to engineer an antibody, ZAb_FLEP, that targets a highly networked and therefore mutationally constrained surface formed by the envelope protein dimer...
May 9, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29746468/seasonal-temperature-variation-influences-climate-suitability-for-dengue-chikungunya-and-zika-transmission
#14
John H Huber, Marissa L Childs, Jamie M Caldwell, Erin A Mordecai
Dengue, chikungunya, and Zika virus epidemics transmitted by Aedes aegypti mosquitoes have recently (re)emerged and spread throughout the Americas, Southeast Asia, the Pacific Islands, and elsewhere. Understanding how environmental conditions affect epidemic dynamics is critical for predicting and responding to the geographic and seasonal spread of disease. Specifically, we lack a mechanistic understanding of how seasonal variation in temperature affects epidemic magnitude and duration. Here, we develop a dynamic disease transmission model for dengue virus and Aedes aegypti mosquitoes that integrates mechanistic, empirically parameterized, and independently validated mosquito and virus trait thermal responses under seasonally varying temperatures...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29745863/generation-and-comparative-genomics-of-synthetic-dengue-viruses
#15
Eli Goz, Yael Tsalenchuck, Rony Oren Benaroya, Zohar Zafrir, Shimshi Atar, Tahel Altman, Justin Julander, Tamir Tuller
BACKGROUND: Synthetic virology is an important multidisciplinary scientific field, with emerging applications in biotechnology and medicine, aiming at developing methods to generate and engineer synthetic viruses. In particular, many of the RNA viruses, including among others the Dengue and Zika, are widespread pathogens of significant importance to human health. The ability to design and synthesize such viruses may contribute to exploring novel approaches for developing vaccines and virus based therapies...
May 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29743741/computed-tomography-and-magnetic-resonance-imaging-findings-in-infants-with-microcephaly-potentially-related-to-congenital-zika-virus-infection
#16
Aníbal Araujo Alves Peixoto Filho, Simone Baltar de Freitas, Márcio Morikoshi Ciosaki, Lourenço Nogueira E Oliveira, Onildo Tavares Dos Santos Júnior
The recent association between the increase in the number of neonates with microcephaly in northeastern Brazil and the outbreak of infection with the Zika virus, which has been occurring in the Americas, has been declared a public health emergency of international concern. The evidence that implicates the virus as the cause of this public health emergency has been demonstrated ever more consistently. This pictorial essay illustrates the imaging characteristics seen on computed tomography and magnetic resonance imaging scans of infants admitted to a rehabilitation hospital with a diagnosis of microcephaly and a maternal history of rash during pregnancy...
March 2018: Radiologia Brasileira
https://www.readbyqxmd.com/read/29742377/revisiting-blood-safety-practices-given-emerging-data-about-zika-virus
#17
Evan M Bloch, Paul M Ness, Aaron A R Tobian, Jeremy Sugarman
The rapid, pandemic spread of Zika virus (ZIKV) spurred an international public health emergency in 2015. Cases of ZIKV infection have now been reported in 85 countries or territories; in 72 of those locations, no such cases had been reported previously. The association of ZIKV with severe..
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29740962/identification-of-broad-spectrum-dengue-zika-virus-replication-inhibitors-by-functionalization-of-quinoline-and-2-6-diaminopurine-scaffolds
#18
Suzanne J F Kaptein, Paolo Vincetti, Emmanuele Crespan, Jorge I Armijos-Rivera, Gabriele Costantino, Giovanni Maga, Johan Neyts, Marco Radi
Social and demographic changes over the past 50 years resulted in important outbreaks of arboviruses such as dengue virus (DENV) and Zika virus (ZIKV) all over the world. Despite such potential threat, no approved drugs or fully protective vaccines are available to counteract DENV and ZIKV spreading. The development of "broad spectrum" antivirals (BSAs) targeting common components of multiple viruses, can be a more effective strategy to limit the rapid rise of emerging viral pathogens than the classic "one-bug/one-drug" approach...
May 9, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29740383/nervous-system-injury-and-neuroimaging-of-zika-virus-infection
#19
REVIEW
Shanshan Wu, Yu Zeng, Alexander Lerner, Bo Gao, Meng Law
In 2016, World Health Organization announced Zika virus infection and its neurological sequalae are a public health emergency of global scope. Preliminary studies have confirmed a relationship between Zika virus infection and certain neurological disorders, including microcephaly and Guillain-Barre syndrome (GBS). The neuroimaging features of microcephaly secondary to Zika virus infection include calcifications at the junction of gray-white matter and subcortical white matter with associated cortical abnormalities, diminution of white matter, large ventricles with or without hydrocephalus, cortical malformations, hypoplasia of cerebellum and brainstem, and enlargement of cerebellomedullary cistern...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29739925/re-visiting-the-evolution-dispersal-and-epidemiology-of-zika-virus-in-asia
#20
John H-O Pettersson, Jon Bohlin, Myrielle Dupont-Rouzeyrol, Ola B Brynildsrud, Kristian Alfsnes, Van-Mai Cao-Lormeau, Michael W Gaunt, Andrew K Falconar, Xavier de Lamballerie, Vegard Eldholm, Didier Musso, Ernest A Gould
Based on serological evidence and viral isolation, Zika virus (ZIKV) has circulated for many years relatively benignly in a sylvatic cycle in Africa and an urban cycle in South East Asia (SEA). With the recent availability of limited but novel Indian ZIKV sequences to add to the plethora of SEA sequences, we traced the phylogenetic history and spatio-temporal dispersal pattern of ZIKV in Asia prior to its explosive emergence in the Pacific region and the Americas. These analyses demonstrated that the introduction and dispersal of ZIKV on the Pacific islands were preceded by an extended period of relatively silent transmission in SEA, enabling the virus to expand geographically and evolve adaptively before its unanticipated introduction to immunologically naive populations on the Pacific islands and in the Americas...
May 9, 2018: Emerging Microbes & Infections
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