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tuberculosis, pulmonary fibrosis, pulmonary hypertension

Stephen P Newman
The repurposing of drug delivery by the pulmonary route has been applied to treatment and prophylaxis of an increasingly wide range of respiratory diseases. Repurposing has been most successful for the delivery of inhaled bronchodilators and corticosteroids in patients with asthma and chronic obstructive pulmonary disease (COPD). Repurposing utilizes the advantages that the pulmonary route offers in terms of more targeted delivery to the site of action, the use of smaller doses, and a lower incidence of side-effects...
April 10, 2018: Advanced Drug Delivery Reviews
Tongxi Liu, Li Gao, Sheng Xie, Hongliang Sun, Min Liu, Zhenguo Zhai
PURPOSE: Fibrosing mediastinitis (FM) is a rare disorder characterized by an excessive fibrotic reaction within the mediastinum, which can result in compression of mediastinal structures. To investigate the clinical and imaging characteristics of TB-associated FM, patients with evidence of TB infection were retrospectively evaluated in this study. MATERIALS AND METHODS: A total of 33 patients with clinically diagnosed FM and evidence of TB infection were selected from the database of two institutional medical centers...
January 22, 2018: Clinical Respiratory Journal
Zhe Chen, Meiqing Liu, Lanfang Li, Linxi Chen
Warburg effect, as an energy shift from mitochondrial oxidative phosphorylation to aerobic glycolysis, is extensively found in various cancers. Interestingly, increasing researchers show that Warburg effect plays a crucial role in non-tumor diseases. For instance, inhibition of Warburg effect can alleviate pulmonary vascular remodeling in the process of pulmonary hypertension (PH). Interference of Warburg effect improves mitochondrial function and cardiac function in the process of cardiac hypertrophy and heart failure...
April 2018: Journal of Cellular Physiology
Runzhen Zhao, Zhenlei Su, Jing Wu, Hong-Long Ji
BACKGROUND: Cell therapy holds the most promising for acute and chronic deleterious respiratory diseases. However, the safety and tolerance for lung disorders are controversy. METHODS: We undertook a systematic review and meta-analyses of all 23 clinical studies of cell therapy. The outcomes were odds ratio (OR), risk difference (RD), Peto OR, relative risk, and mean difference of serious adverse events. RESULTS: 342 systemic infusions and 57 bronchial instillations (204 recipients) of cells were analyzed for acute respiratory distress syndrome (ARDS), bronchopulmonary dysplasia, pulmonary arterial hypertension, silicosis, sarcoidosis, extensively drug-resistant tuberculosis, chronic obstructive pulmonary diseases (COPD), and idiopathic pulmonary fibrosis...
May 2, 2017: Oncotarget
J P Liao, Y Hu, J X Qiu, Z Jin, H Zhang, J Ma, G F Wang
Objective: To investigate the clinical characteristics and prognosis of mediastinal fibrosis. Methods: Twelve patients with mediastinal fibrosis diagnosed between 2008 and 2015 in our hospital were studied retrospectively. Clinical manifestations, radiological characteristics, endoscopic features, treatment and prognosis were analyzed. Results: There were 3 males and 9 females, with a mean age of 68.8 years.Six patients had previous tuberculosis infection. The most common clinical symptoms were dyspnea on exertion (11 cases), cough (7 cases), and wheezing (6 cases)...
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
Parthasarathi Bhattacharyya, Dipanjan Saha, Pratyaya Deep Bhattacherjee, Soumen Kumar Das, Pinak Pani Bhattacharyya, Ratna Dey
BACKGROUND: Pulmonary tuberculosis is not listed as a cause of pulmonary hypertension (PH). Scanty information is available in the literature regarding this issue. METHODS: A group of patients with a history of pulmonary tuberculosis were diagnosed to have PH on the basis of a novel clinico-radio-echocardiographic criteria. Subdivided into two groups on the basis of the history of smoking, we looked for their demographic, spirometric, radiological characteristics along with the quality of life assessment...
March 2016: Lung India: Official Organ of Indian Chest Society
Hyojin Kim, Yoon Kyung Jeon, Hyun Joo Lee, Young Tae Kim, Doo Hyun Chung
Recently, the numbers of lung transplantation (LT) has been increased in Korea. However, post-LT outcome has not been successful in all patients, which may be partially affected by the primary lung disease. Therefore comprehensive understanding in original pathological diagnosis of patients with LT would be needed for achieving better clinical outcome. To address this issue, we performed clinico-pathological analysis of the explanted lungs from 29 patients who underwent LT over a 9-yr period in Seoul National University Hospital...
October 2015: Journal of Korean Medical Science
Beth L Laube
Inhalation therapy has matured to include drugs that: (1) deliver nucleic acids that either lead to the restoration of a gene construct or protein coding sequence in a population of cells or suppress or disrupt production of an abnormal gene product (gene therapy); (2) deliver peptides that target lung diseases such as asthma, sarcoidosis, pulmonary hypertension, and cystic fibrosis; and (3) deliver peptides to treat diseases outside the lung whose target is the systemic circulation (systemic drug delivery)...
June 2015: Respiratory Care
Mediha Ibrahim, Ajsza Matela, Shilpa Desouza, Joseph Mathew
Pleural Case Report PostersSESSION TYPE: Affiliate Case Report PosterPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Dense fibrous tissue may form over the pleural surface for a variety of reasons. Pleural fibrosis usually follows intense inflammation of the pleura; however, the mechanisms following the inflammatory process leading up to fibrosis are unclear.CASE PRESENTATION: A 60-year-old Liberian woman presented to our institution complaining of dyspnea and leg edema for 3 months...
October 1, 2014: Chest
Alina Croitoru, Miron Alexandru Bogdan
Pulmonary rehabilitation represents a modern therapeutic approach of respiratory diseases, with a multidisciplinary character, including: physical training, therapeutic education, psychosocial counseling, and nutritional approach. Pulmonary rehabilitation addresses to any patient suffering from pulmonary pathology whose quality of life is affected by the respiratory symptoms, regardless of the degree of functional impairment. This article is an analysis of evidences from the medical literature on outcomes of rehabilitation programs conducted in various lung diseases...
April 2014: Pneumologia: Revista Societății Române de Pneumologie
P N Liubchenko, A A Atamanchuk, E A Poliakova, E B Shirokova, L I Dmitruk, E N Ian'shina
The article covers data on occupational morbidity in Moscow region over last 50 years. Stable number of newly diagnosed occupational diseases was seen up to first half of 1990s. Afterwards, steady decrease in occupational morbidity is seen with closure of major industrial enterprises. Among occupational pulmonary diseases, dust fibrosis (pneumoconiosis--44%) prevail. Tuberculosis complication of silicosis decreased, additional general somatic concomitants (arterial hypertension, ischemic heart disease, malignancies) are more frequent...
2014: Meditsina Truda i Promyshlennaia Ekologiia
Giuseppe Murdaca, Francesca Spanò, Miriam Contatore, Andrea Guastalla, Francesco Puppo
Systemic sclerosis (SSc) is a rare connective tissue disease characterized by chronic inflammation and fibrosis of the skin, vascular abnormalities and variable involvement of organs. TNF-α has a central role in initial host response to infections and in the pathogenesis of various systemic immune-mediated diseases. Serum levels of TNF-α are elevated in patients with SSc and favor the development of pulmonary fibrosis and pulmonary arterial hypertension. Inflammatory arthritis can occur in patients with SSc...
2014: Immunotherapy
C Daccord, J-W Fitting
During pregnancy several adaptations develop in response to the enhanced maternal and fetal metabolic needs. This review summarizes the major cardiorespiratory modifications of pregnancy as well as their consequences in chronic respiratory diseases such as restrictive ventilatory defects (post-tuberculosis pneumonectomy, kyphoscoliosis, neuromuscular disorders), asthma, cystic fibrosis, and pulmonary hypertension. It is important to recognize early the cardiorespiratory situations for which pregnancy is contraindicated or associated with a high risk of respiratory complications...
November 20, 2013: Revue Médicale Suisse
Charo Francisco
SESSION TYPE: ILD Global Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Interstitial lung disease (ILD) includes a large, heterogeneous group of mostly rare pulmonary conditions that cause derangements of the alveolar walls and loss of functional alveolar capillary units, consisting of both known and unknown causes that share common histological features. It is influenced by several factors such as host susceptibility, genetics and environmental aspects. Familial ILD is identified by verifying in two or more members of the same family...
October 1, 2012: Chest
Hanna Meleth, Gopinathan Pisharath
SESSION TYPE: ILD Student/Resident Case Report PostersPRESENTED ON: Tuesday, October 23, 2012 at 01:30 PM - 02:30 PMINTRODUCTION: Interstitial Lung Disease (ILD) revised and termed as Diffuse Parenchymal Lung Disease (DPLD) is a slowly progressive inflammatory disease of diverse etiology, primarily involving the interstitium and not uncommonly the alveoli and lower airways. Of them, Idiopathic Pulmonary Fibrosis (IPF) is a distinct clinical entity rather than a diagnosis of exclusion, diagnosed with High Resolution Computerised Tomography (HRCT) duly supported by suggestive clinical profile...
October 1, 2012: Chest
Avignat S Patel, Danielle Morse, Augustine M K Choi
Autophagy is a homeostatic process common to all eukaryotic cells that serves to degrade intracellular components. Among three classes of autophagy, macroautophagy is best understood, and is the subject of this Review. The function of autophagy is multifaceted, and includes removal of long-lived proteins and damaged or unneeded organelles, recycling of intracellular components for nutrients, and defense against pathogens. This process has been extensively studied in yeast, and understanding of its functional significance in human disease is also increasing...
January 2013: American Journal of Respiratory Cell and Molecular Biology
J L Rakotoson, H M D Vololontiana, R E Raherison, R Andrianasolo, J R Rakotomizao, M J D Randria, R F Rapelanoro, A C F Andrianarisoa, H R Rajaona
We report a rare case of a huge aspergilloma developed within a bronchiectasis due to pulling by a pulmonary fibrosis of systemic scleroderma. The patient is a 58-year-old woman presenting a deterioration of the general state associated with repeating hemoptysis, dyspnea, dysphagia, sclérodactylia, generalized cutaneous sclerosis and Raynaud's phenomenon. There was no antecedent pulmonary tuberculosis. The patient had a pulmonary arterial hypertension complicated by a chronic pulmonary heart at the stage of right cardiac decompensation...
December 2011: Bulletin de la Société de Pathologie Exotique
Rajan Kochar, Michael B Fallon
Chronic liver disease is associated with many pulmonary complications. Several, including hepatopulmonary syndrome, portopulmonary hypertension, and hepatic hydrothorax have been extensively reviewed. However, hepatobiliary manifestations of primary pulmonary diseases have received less attention. This review focuses on hepatobiliary complications of respiratory failure, cystic fibrosis, α-1 antitrypsin deficiency, sarcoidosis, and tuberculosis.
February 2011: Clinics in Liver Disease
C A Jetan, I Jamaiah, M Rohela, V Nissapatorn
This was an eight year (2000-2007) retrospective study of tuberculosis in patients admitted to the UMMC. A total of 131 cases were analyzed. Malays constituted the most cases, (43%), followed by Chinese (22%), Indians (17%) and others (18%). The majority of cases were within the 21-60 year old age group, which constituted 69.5% of the total. Males were more commonly affected (65%). Most cases were reported among Malaysians (83%). The majority of patients were unemployed (39%), followed by housewives (10%), laborers (9%), students (8%), shop assistants (7%), and other occupations (27%)...
March 2010: Southeast Asian Journal of Tropical Medicine and Public Health
Shao-hua Lu, Ying-yong Hou, Yun-shan Tan, Tao Liu, Qun Wang, Chun-xue Bai
OBJECTIVE: To investigate the clinicopathological and CT features of primary pulmonary cryptococcosis (PC), and its underlying reasons for misdiagnosis. METHODS: The clinical data and pathological features of 52 cases of PC in Zhongshan Hospital from 1998 to 2008 were retrospectively reviewed. RESULTS: The 52 patients consisted of 36 males and 16 females aged from 17 to 80 years, with a median age of 48. The early symptoms were cough, phlegm and chest pain...
June 2009: Chinese Journal of Tuberculosis and Respiratory Diseases
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