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Lugano criteria

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https://www.readbyqxmd.com/read/27901328/prognostic-value-of-interim-fdg-pet-ct-in-patients-older-than-60-years-with-diffuse-large-b-cell-lymphoma-treated-by-pmitcebo-plus-rituximab-comparison-between-deauville-5-point-scale-and-international-harmonization-project-criteria
#1
Naelle Lombion, Philippe Robin, Adrian Tempescul, Pierre Y LE Roux, Ulrike Schick, Gaëlle Guillerm, Jean C Ianotto, Christian Berthou, Pierre Y Salaün, Ronan Abgral
BACKGROUND: Advanced age is an independent poor prognostic factor of diffuse large B-cell lymphoma. PMitCEBO is an alternative to CHOP to decrease side effects in elderly patients. Many studies have shown prognostic value of an interim FDG PET-CT to predict survival. A recent consensus (ICML, Lugano 2013) has suggested using the 5-point scale Deauville criteria instead of those of the international harmonization project (IHP) to visually assess the response on interim PET. The objective of this study was to evaluate the prognostic value of an interim FDG PET-CT in patients older than 60 with treated DLBCL and to compare IHP and 5-PS Deauville visual interpretation to predict survival...
November 30, 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27873064/development-of-diffuse-large-b-cell-lymphoma-from-follicular-lymphoma-of-the-duodenum-changes-in-endoscopic-findings-during-a-6-year-follow-up
#2
Hiroyuki Kitabatake, Tadanobu Nagaya, Naoki Tanaka, Hiroyoshi Ota, Kenji Sano, Naoko Asano, Tomoaki Suga, Yoshiyuki Nakamura, Taiji Akamatsu, Eiji Tanaka
A 71-year-old Japanese man was diagnosed as having stage I primary follicular lymphoma (FL) of the duodenum according to Lugano International Conference Classification and began receiving annual checkups. Endoscopic examination disclosed white villi swelling with depressed red mucosal lesions. Biopsy specimens from the area of white villi exhibited histopathological features that met the diagnostic criteria for low-grade FL. The depressed red lesions gradually enlarged over six years of follow-up. A biopsy of the white villi swelling revealed distinct well-circumscribed follicles with attenuated mantles in the lamina propria that were positive for CD20, bcl-2, and CD10...
November 21, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/27627889/different-predictive-values-of-interim-18-f-fdg-pet-ct-in-germinal-center-like-and-non-germinal-center-like-diffuse-large-b-cell-lymphoma
#3
Jihyun Kim, Jeong-Ok Lee, Jin Ho Paik, Won Woo Lee, Sang Eun Kim, Yoo Sung Song
PURPOSE: Diffuse large B-cell lymphoma (DLBCL) is a pathologically heterogeneous disease with different prognoses according to its molecular profiles. Despite the broad usage of (18)F-fluoro-2-dexoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT), previous studies that have investigated the value of interim (18)F-FDG PET/CT in DLBCL have given the controversial results. The purpose of this study was to evaluate the prognostic value of interim (18)F-FDG PET/CT in DLBCL according to germinal center B cell-like (GCB) and non-GCB molecular profiling...
September 15, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27574190/refinement-of-the-lugano-classification-response-criteria-for-lymphoma-in-the-era-of-immunomodulatory-therapy
#4
Bruce D Cheson, Stephen Ansell, Larry Schwartz, Leo I Gordon, Ranjana Advani, Heather A Jacene, Axel Hoos, Sally F Barrington, Philippe Armand
Uniformly adopted response criteria are essential for assessment of therapies incorporating conventional chemotherapy and chemoimmunotherapy regimens. Recently, immunomodulatory agents, such as immune checkpoint inhibitors, have demonstrated impressive activity in a broad range of lymphoma histologies. However, these agents may be associated with clinical and imaging findings during treatment suggestive of progressive disease (PD) despite evidence of clinical benefit (e.g., tumor flare or pseudo-progression)...
August 29, 2016: Blood
https://www.readbyqxmd.com/read/27534788/-staging-and-treatment-response-evaluation-in-malignant-lymphomas-czech-lymphoma-study-group-recommendations-according-to-criteria-revised-in-2014-lugano-classification
#5
A Sýkorová, R Pytlík, H Móciková, D Belada, K Benešová, T Papajík, A Janíková, D Šálek, V Procházka, S Vokurka, V Campr, P Klener, K Kubáčková, M Trněný
BACKGROUND: Recent advances in the use of the imaging modalities, especially PET/CT, and their utilization for determining clinical stage (CS) and assessment treatment response (TR) in malignant lymphomas, along with development of prognostic tools and new treatment modalities, formed the basis for the revised criteria for evaluating CS and TR (published as the Lugano classification, 2014). MATERIALS AND METHODS: The authors summarize the new Lugano recommendations (published in 2014) and the changes from the criteria published in 2007...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/26203705/imaging-for-staging-and-response-assessment-in-lymphoma
#6
REVIEW
Sarah A Johnson, Anita Kumar, Matthew J Matasar, Heiko Schöder, Jürgen Rademaker
Lymphoma comprises a heterogeneous group of diseases; remarkable advances have been made in diagnosis and treatment. Diagnostic imaging provides important information for staging and response assessment in patients with lymphoma. Over the years, staging systems have been refined, and dedicated criteria have been developed for evaluating response to therapy with both computed tomography (CT) and fluorine-18 fluorodeoxyglucose positron emission tomography (PET)/CT. The most recent system proposed for staging and response assessment, known as the Lugano classification, applies to both Hodgkin and non-Hodgkin lymphoma...
August 2015: Radiology
https://www.readbyqxmd.com/read/25975729/rethinking-clinical-response-and-outcome-assessment-in-a-biologic-age
#7
REVIEW
Bruce D Cheson
Standardized response criteria for lymphoma are critical for the evaluation of new therapies. Widely adopted recommendations, most recently the Lugano classification, have been developed primarily for assessment of conventional chemotherapeutic regimens. More recently, several classes of drugs, including immunomodulatory agents, B cell receptor pathway targeting kinases, and checkpoint (PD-1, PDL-1) inhibitors have demonstrated impressive activity in a broad range of histologies. However, they may be associated with features during treatment suggestive of progressive disease despite clinical benefit...
June 2015: Current Oncology Reports
https://www.readbyqxmd.com/read/25841712/staging-and-response-assessment-in-lymphomas-the-new-lugano-classification
#8
REVIEW
Bruce D Cheson
Staging and response criteria were initially developed for Hodgkin lymphoma (HL) over 60 years ago, but not until 1999 were response criteria published for non-HL (NHL). Revisions to these criteria for both NHL and HL were published in 2007 by an international working group, incorporating PET for response assessment, and were widely adopted. After years of experience with these criteria, a workshop including representatives of most major international lymphoma cooperative groups and cancer centers was held at the 11(th) International Conference on Malignant Lymphoma (ICML) in June, 2011 to determine what changes were needed...
March 2015: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/25731535/-salvage-gastrectomy-and-radiotherapy-for-r-chop-refractory-gastric-malignant-lymphoma
#9
Shigeru Shibata, Harue Akasaka, Taiichi Wakiya, Yuji Yamanaka, Junichi Narita, Takemichi Sutou, Chikara Iino
A man in his seventies presented with a stomach abnormality that was revealed upon physical examination.Following workup, he was diagnosed with gastric diffuse large B-cell lymphoma (DLBCL)StageII1 (Lugano staging system for gastrointestinal lymphoma) with low risk as defined by the International Prognostic Index criteria.The entire stomach showed an intense, abnormal FDG uptake by FDG-PET evaluation.He was treated with rituximab plus CHOP (R-CHOP).The patient's body weight decreased by 12 kg during the treatment period...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/25513469/recommendations-for-initial-evaluation-staging-and-response-assessment-of-hodgkin-and-non-hodgkin-lymphoma-the-lugano-classification
#10
Bruce D Cheson, Richard I Fisher, Sally F Barrington, Franco Cavalli, Lawrence H Schwartz, T Andrew Lister
The purpose of this work was to modernize recommendations for evaluation, staging, and response assessment of patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A workshop was held at the 11th International Conference on Malignant Lymphoma in Lugano, Switzerland, in June 2011, that included leading hematologists, oncologists, radiation oncologists, pathologists, radiologists, and nuclear medicine physicians, representing major international lymphoma clinical trials groups and cancer centers...
September 20, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/25513468/role-of-imaging-in-the-staging-and-response-assessment-of-lymphoma-consensus-of-the-international-conference-on-malignant-lymphomas-imaging-working-group
#11
Sally F Barrington, N George Mikhaeel, Lale Kostakoglu, Michel Meignan, Martin Hutchings, Stefan P Müeller, Lawrence H Schwartz, Emanuele Zucca, Richard I Fisher, Judith Trotman, Otto S Hoekstra, Rodney J Hicks, Michael J O'Doherty, Roland Hustinx, Alberto Biggi, Bruce D Cheson
PURPOSE: Recent advances in imaging, use of prognostic indices, and molecular profiling techniques have the potential to improve disease characterization and outcomes in lymphoma. International trials are under way to test image-based response–adapted treatment guided by early interim positron emission tomography (PET)–computed tomography (CT). Progress in imaging is influencing trial design and affecting clinical practice. In particular, a five-point scale to grade response using PET-CT, which can be adapted to suit requirements for early- and late-response assessment with good interobserver agreement, is becoming widely used both in practice- and response-adapted trials...
September 20, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/25431864/testicular-germ-cell-tumors-in-adolescents-results-of-the-protocol-maho-98-and-the-identification-of-good-risk-patients
#12
U Göbel, G Calaminus, R Haas, C Teske, S Schönberger, D T Schneider, I Leuschner, D Harms
BACKGROUND: In adolescents aged 10-15 years germ cell tumors of the testis (TGCT) are rare and information for a risk adapted therapy limited. AIMS OF THE STUDY: The protocol MAHO 98 for patients (pts) with TGCTs is stratified according to age, stage and histology. Pts ≥ 10 years received after tumororchiectomy 2 courses (crs) PVB and restaging. Residual tumor was resected and therapy continued in regard to inital stage and response. Chemotherapy: PVB: cisplatin (20 mg/m²/day 1-5), vinblastine (3 mg/m²/day 1+2), and bleomycin (15 U/m²/day 1-3)...
November 2014: Klinische Pädiatrie
https://www.readbyqxmd.com/read/25113771/role-of-imaging-in-the-staging-and-response-assessment-of-lymphoma-consensus-of-the-international-conference-on-malignant-lymphomas-imaging-working-group
#13
Sally F Barrington, N George Mikhaeel, Lale Kostakoglu, Michel Meignan, Martin Hutchings, Stefan P Müeller, Lawrence H Schwartz, Emanuele Zucca, Richard I Fisher, Judith Trotman, Otto S Hoekstra, Rodney J Hicks, Michael J O'Doherty, Roland Hustinx, Alberto Biggi, Bruce D Cheson
PURPOSE: Recent advances in imaging, use of prognostic indices, and molecular profiling techniques have the potential to improve disease characterization and outcomes in lymphoma. International trials are under way to test image-based response–adapted treatment guided by early interim positron emission tomography (PET)–computed tomography (CT). Progress in imaging is influencing trial design and affecting clinical practice. In particular, a five-point scale to grade response using PET-CT, which can be adapted to suit requirements for early- and late-response assessment with good interobserver agreement, is becoming widely used both in practice- and response-adapted trials...
September 20, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/25113753/recommendations-for-initial-evaluation-staging-and-response-assessment-of-hodgkin-and-non-hodgkin-lymphoma-the-lugano-classification
#14
Bruce D Cheson, Richard I Fisher, Sally F Barrington, Franco Cavalli, Lawrence H Schwartz, Emanuele Zucca, T Andrew Lister
The purpose of this work was to modernize recommendations for evaluation, staging, and response assessment of patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A workshop was held at the 11th International Conference on Malignant Lymphoma in Lugano, Switzerland, in June 2011, that included leading hematologists, oncologists, radiation oncologists, pathologists, radiologists, and nuclear medicine physicians, representing major international lymphoma clinical trials groups and cancer centers...
September 20, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/24694866/the-impact-of-search-engine-selection-and-sorting-criteria-on-vaccination-beliefs-and-attitudes-two-experiments-manipulating-google-output
#15
Ahmed Allam, Peter Johannes Schulz, Kent Nakamoto
BACKGROUND: During the past 2 decades, the Internet has evolved to become a necessity in our daily lives. The selection and sorting algorithms of search engines exert tremendous influence over the global spread of information and other communication processes. OBJECTIVE: This study is concerned with demonstrating the influence of selection and sorting/ranking criteria operating in search engines on users' knowledge, beliefs, and attitudes of websites about vaccination...
2014: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/23763460/report-on-the-4th-international-workshop-on-positron-emission-tomography-in-lymphoma-held-in-menton-france-3-5-october-2012
#16
Michel Meignan, Sally Barrington, Emmanuel Itti, Andrea Gallamini, Corinne Haioun, Aaron Polliack
One hundred and seventy-five hemato-oncologists and nuclear medicine specialists from 23 countries joined the 2-day 4th International Workshop on Positron Emission Tomography in Lymphoma held in October 2012. The meeting was under the auspices of the European Lymphoma Institute, the Lymphoma Study Association (LYSA) and Fondazione Italiana Linfomi (FIL). Thirty-nine scientific posters were presented or discussed in the plenary session. A group of nuclear medicine and radiology experts presented and discussed with the audience their final report on lymphoma staging and restaging with positron emission tomography (PET)...
January 2014: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/23462389/objective-way-to-support-embryo-transfer-a-probabilistic-decision
#17
L Gianaroli, M C Magli, L Gambardella, A Giusti, C Grugnetti, G Corani
STUDY QUESTION: Is it feasible to identify factors that significantly affect the clinical outcome of IVF-ICSI cycles and use them to reliably design a predictor of implantation? SUMMARY ANSWER: The Bayesian network (BN) identified top-history embryos, female age and the insemination technique as the most relevant factors for predicting the occurrence of pregnancy (AUC, area under curve, of 0.72). In addition, it could discriminate between no implantation and single or twin implantations in a prognostic model that can be used prospectively...
May 2013: Human Reproduction
https://www.readbyqxmd.com/read/16266874/-recommendations-for-the-management-of-gist-patients
#18
Jean-Yves Blay, Bruno Landi, Sylvie Bonvalot, Geneviève Monges, Isabelle Ray-Coquard, Florence Duffaud, Nguyen Binh Bui, Roland Bugat, Jean-Alain Chayvialle, Philippe Rougier, Olivier Bouché, Françoise Bonichon, Nathalie Lassau, Daniel Vanel, Bernard Nordlinger, Eberhard Stoeckle, Pierre Meeus, Jean-Michel Coindre, Jean-Yves Scoazec, Jean-François Emile, Dominique Ranchère, Axel Le Cesne
BACKGROUND: The management of gastrointestinal stromal tumors (GIST) has evolved very rapidly in the last years. A national consensus meeting was therefore organized in order to identify the optimal management procedures for patients with GIST in localized and advanced stages. METHODS: A panel of different specialties, including pathology, molecular biology, imaging, surgery, gastroenterology, medical oncology reviewed the current literature, in particular the recent Lugano conference, to identify consensus points and topics for future research in four different working groups: pathology and molecular biology, early management of small tumors and imaging, surgery, and medical treatment...
October 2005: Bulletin du Cancer
https://www.readbyqxmd.com/read/9743819/effects-of-oral-chondroitin-sulfate-on-the-progression-of-knee-osteoarthritis-a-pilot-study
#19
RANDOMIZED CONTROLLED TRIAL
D Uebelhart, E J Thonar, P D Delmas, A Chantraine, E Vignon
The aim of this study was to assess the clinical, radiological and biological efficacy and tolerability of the SYSADOA, chondroitin 4- and 6-sulfate (CS, Condrosulf, IBSA, Lugano, Switzerland), in patients suffering from knee osteoarthritis. This was a 1-year, randomized, double-blind, controlled pilot study which included 42 patients of both sexes, aged 35-78 years with symptomatic knee OA. Patients were treated orally with 800 mg chondroitin sulfate (CS) per day or with a placebo (PBO) administered in identical sachets...
May 1998: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/8513838/modified-retroperitoneal-lymphadenectomy-for-testicular-tumor-anatomical-approach-operative-technique-and-results
#20
A Hobisch, K Colleselli, O Ennemoser, W Horninger, S Poisel, G Janetschek, G Bartsch
Between January 1988 and June 1992, 56 patients underwent nerve-preserving retroperitoneal lymphadenectomy at the Department of Urology, University of Innsbruck. In 23 patients stage I, and in 33 patients stage II testicular tumors were found (staging according to the criteria recommended in Lugano 1979). Orchiectomy and subsequent lymphadenectomy within the boundaries described by Weissbach's group were performed for stage I tumors. In patients presenting with stage IIa or IIb tumors modified retroperitoneal lymphadenectomy within the boundaries suggested by Colleselli's group was performed...
1993: European Urology
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