Niqin Xiao, Zhaohu Xie, Zhiyan He, Yundong Xu, Shuyu Zhen, Yuanyuan Wei, Xiaoyu Zhang, Jiayan Shen, Jian Wang, Yadan Tian, Jinlian Zuo, Jiangyun Peng, Zhaofu Li
Gout is a chronic metabolic and immune disease, and its specific pathogenesis is still unclear. When the serum uric acid exceeds its saturation in the blood or tissue fluid, it is converted to monosodium urate crystals, which lead to acute arthritis of varying degrees, urinary stones, or irreversible peripheral joint damage, and in severe cases, impairment of vital organ function. Gout flare is a clinically significant state of acute inflammation in gout. The current treatment is mostly anti-inflammatory analgesics, which have numerous side effects with limited treatment methods...
April 2024: International Journal of Rheumatic Diseases