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https://www.readbyqxmd.com/read/28812903/synergic-on-off-photoswitching-spin-state-and-magnetic-coupling-between-spin-crossover-centers
#1
Jun-Li Wang, Qiang Liu, Yin-Shan Meng, Hui Zheng, Hai-Lang Zhu, Quan Shi, Tao Liu
The existence of a correlation between spin crossover and dielectric properties is a hot topic in the field of multiresponse materials, which has potential applications in the memory devices, switches, and sensors. One formidable challenge is the simultaneous and rapid on/off switching of spin states of the spin carriers and magnetic coupling between them, which is crucial for both reversible photomagnetic behavior and variations in dielectric properties. Here, we report a dinuclear Fe(II) spin crossover complex, wherein each Fe(II) center exhibits an interconversion between Fe(II)HS (HS = high-spin) and Fe(II)LS (LS = low-spin) achieved upon heating and cooling...
August 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28812799/current-models-of-investor-state-dispute-settlement-are-bad-for-health-the-european-union-could-offer-an-alternative-comment-on-the-trans-pacific-partnership-is-it-everything-we-feared-for-health
#2
Martin McKee, David Stuckler
In this commentary, we endorse concerns about the health impact of the trans-pacific partnership (TPP), paying particular attention to its mechanisms for investor state dispute settlement. We then describe the different, judge-led approach being advocated by the European Commission team negotiating the Trans-Atlantic Trade and Investment Partnership, arguing that, while not perfect, it offers significant advantages.
August 20, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812627/direct-observation-of-increasing-recovery-length-before-collapse-of-a-marine-benthic-ecosystem
#3
Luca Rindi, Martina Dal Bello, Lei Dai, Jeff Gore, Lisandro Benedetti-Cecchi
Ecosystems can experience catastrophic transitions to alternative states, yet recent results have suggested that slowing down in rates of recovery after a perturbation may provide advance warning that a critical transition is approaching. Perturbation experiments with microbial populations have supported this hypothesis under controlled laboratory conditions, but evidence from natural ecosystems remains rare. Here, we manipulated rocky intertidal canopy algae to test the hypothesis that the spatial scale at which the system recovers from a perturbation in space should increase as the system approaches the tipping point, marking the transition from a canopy-dominated to a turf-dominated state...
May 8, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812618/plant-spatial-patterns-identify-alternative-ecosystem-multifunctionality-states-in-global-drylands
#4
Miguel Berdugo, Sonia Kéfi, Santiago Soliveres, Fernando T Maestre
The response of drylands to environmental gradients can be abrupt rather than gradual. These shifts largely occur unannounced and are difficult to reverse once they happen; their prompt detection is of crucial importance. The distribution of vegetation patch sizes may indicate the proximity to these shifts, but the use of this metric is hampered by a lack of large-scale studies relating these distributions to the provision of multiple ecosystem functions (multifunctionality) and comparing them to other ecosystem attributes, such as total plant cover...
January 9, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811463/a-light-regulated-host-guest-based-nanochannel-system-inspired-by-channelrhodopsins-protein
#5
Yue Sun, Junkai Ma, Fan Zhang, Fei Zhu, Yuxiao Mei, Lu Liu, Demei Tian, Haibing Li
The light-controlled gating of ion transport across membranes is central to nature (e.g., in protein channels). Herein, inspired by channelrhodopsins, we introduce a facile non-covalent approach towards light-responsive biomimetic channelrhodopsin nanochannels using host-guest interactions between a negative pillararene host and a positive azobenzene guest. By switching between threading and dethreading states with alternating visible and UV light irradiation, the functional channels can be flexible to regulate the inner surface charge of the channels, which in turn was exploited to achieve different forms of ion transport, for instance, cation-selective transport and anion-selective transport...
August 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28811169/tissue-engineered-extracellular-matrices-ecms-in-urology-evolution-and-future-directions
#6
REVIEW
N F Davis, E M Cunnane, F J O'Brien, J J Mulvihill, M T Walsh
Autologous gastrointestinal tissue has remained the gold-standard reconstructive biomaterial in urology for >100 years. Mucus-secreting epithelium is associated with lifelong metabolic and neuromechanical complications when implanted into the urinary tract. Therefore, the availability of biocompatible tissue-engineered biomaterials such as extracellular matrix (ECM) scaffolds may provide an attractive alternative for urologists. ECMs are decellularised, biodegradable membranes that have shown promise for repairing defective urinary tract segments in vitro and in vivo by inducing a host-derived tissue remodelling response after implantation...
August 12, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28810905/omni-polya-a-method-and-tool-for-accurate-recognition-of-poly-a-signals-in-human-genomic-dna
#7
Arturo Magana-Mora, Manal Kalkatawi, Vladimir B Bajic
BACKGROUND: Polyadenylation is a critical stage of RNA processing during the formation of mature mRNA, and is present in most of the known eukaryote protein-coding transcripts and many long non-coding RNAs. The correct identification of poly(A) signals (PAS) not only helps to elucidate the 3'-end genomic boundaries of a transcribed DNA region and gene regulatory mechanisms but also gives insight into the multiple transcript isoforms resulting from alternative PAS. Although progress has been made in the in-silico prediction of genomic signals, the recognition of PAS in DNA genomic sequences remains a challenge...
August 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28810751/communication-on-the-diffusion-tensor-in-macroscopic-theory-of-cavitation
#8
Vitaly A Shneidman
The classical description of nucleation of cavities in a stretched fluid relies on a one-dimensional Fokker-Planck equation (FPE) in the space of their sizes r, with the diffusion coefficient D(r) constructed for all r from macroscopic hydrodynamics and thermodynamics, as shown by Zeldovich. When additional variables (e.g., vapor pressure) are required to describe the state of a bubble, a similar approach to construct a diffusion tensor D^ generally works only in the direct vicinity of the thermodynamic saddle point corresponding to the critical nucleus...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810589/phenotypic-switch-in-lung-interstitial-macrophage-polarization-in-an-ovalbumin-induced-mouse-model-of-asthma
#9
Hanxiang Nie, Ailing Wang, Qing He, Qiaoyu Yang, Linlin Liu, Guqin Zhang, Yi Huang, Xuhong Ding, Hongying Yu, Suping Hu
Macrophage phenotype and function varies according to their polarized state, which in turn is dependent on microenvironmental stimuli. Under normal physiological conditions, lung interstitial macrophages that express interleukin (IL)-10 are considered to serve regulatory roles in the prevention of allergic reactions in the airways. However, the phenotypic profile of lung interstitial macrophages during the pathophysiology of asthma remains unknown. In the current study, the phenotypic characteristics of lung interstitial macrophages were investigated in an ovalbumin (OVA)-induced mouse model of asthma...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809785/path-planning-for-non-circular-non-holonomic-robots-in-highly-cluttered-environments
#10
Ricardo Samaniego, Joaquin Lopez, Fernando Vazquez
This paper presents an algorithm for finding a solution to the problem of planning a feasible path for a slender autonomous mobile robot in a large and cluttered environment. The presented approach is based on performing a graph search on a kinodynamic-feasible lattice state space of high resolution; however, the technique is applicable to many search algorithms. With the purpose of allowing the algorithm to consider paths that take the robot through narrow passes and close to obstacles, high resolutions are used for the lattice space and the control set...
August 15, 2017: Sensors
https://www.readbyqxmd.com/read/28809042/notes-on-the-overlap-measure-as-an-alternative-to-the-youden-index-how-are-they-related
#11
Hani M Samawi, Jingjing Yin, Haresh Rochani, Viral Panchal
The receiver operating characteristic (ROC) curve is frequently used to evaluate and compare diagnostic tests. As one of the ROC summary indices, the Youden index measures the effectiveness of a diagnostic marker and enables the selection of an optimal threshold value (cut-off point) for the marker. Recently, the overlap coefficient, which captures the similarity between 2 distributions directly, has been considered as an alternative index for determining the diagnostic performance of markers. In this case, a larger overlap indicates worse diagnostic accuracy, and vice versa...
August 15, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28808905/a-pharmacokinetic-bioequivalence-study-comparing-pirfenidone-tablet-and-capsule-dosage-forms-in-healthy-adult-volunteers
#12
Lin Pan, Paula Belloni, Han Ting Ding, Jianshuang Wang, Christopher M Rubino, Wendy S Putnam
INTRODUCTION: Pirfenidone film-coated tablets were developed to offer an alternative to the marketed capsule formulation. This study assessed the bioequivalence of the tablet and capsule formulations under fed and fasted states. METHODS: A Phase I, open-label, randomized, four-treatment-period, four-sequence, crossover pharmacokinetics study (NCT02525484) was conducted. Each subject received an 801-mg single dose of pirfenidone as three 267-mg capsules or one 801-mg tablet under fasted and fed conditions...
August 14, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28808836/excitation-transfer-and-trapping-kinetics-in-plant-photosystem-i-probed-by-two-dimensional-electronic-spectroscopy
#13
Parveen Akhtar, Cheng Zhang, Zhengtang Liu, Howe-Siang Tan, Petar H Lambrev
Photosystem I is a robust and highly efficient biological solar engine. Its capacity to utilize virtually every absorbed photon's energy in a photochemical reaction generates great interest in the kinetics and mechanisms of excitation energy transfer and charge separation. In this work, we have employed room-temperature coherent two-dimensional electronic spectroscopy and time-resolved fluorescence spectroscopy to follow exciton equilibration and excitation trapping in intact Photosystem I complexes as well as core complexes isolated from Pisum sativum...
August 14, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28807647/endogenous-visuospatial-attention-increases-visual-awareness-independent-of-visual-discrimination-sensitivity
#14
Marine Vernet, Shruti Japee, Savannah Lokey, Sara Ahmed, Valentinos Zachariou, Leslie G Ungerleider
Visuospatial attention often improves task performance by increasing signal gain at attended locations and decreasing noise at unattended locations. Attention is also believed to be the mechanism that allows information to enter awareness. In this experiment, we assessed whether orienting endogenous visuospatial attention with cues differentially affects visual discrimination sensitivity (an objective task performance) and visual awareness (the subjective feeling of perceiving) during the same discrimination task...
August 11, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28807554/grassroots-technological-resistance-the-people-s-power-project-and-the-impossible-dream-of-wireless-transmission-of-energy
#15
Pete Schmidt
In 1972, the Minnesota United Power Association (UPA) teamed up with the Minnesota Cooperative Power Association (CPA) to initiate an electrification project designed to bring power from North Dakota to the Twin Cities area. A significant backlash and protest began once farmers across the state became aware of the plan and the potential impending land seizure. In the midst of these actions, one group sought to create an alternative to the power line transmission system by designing a system of wireless energy transmission based on the plans of Nikola Tesla...
August 11, 2017: Endeavour
https://www.readbyqxmd.com/read/28807497/characterisation-of-the-porcine-cytokines-which-activate-the-cd131%C3%AE-c-common-sub-unit-for-potential-immune-augmentation
#16
G Stephenson, K R Morris, T E O'Neil, M P Bruce, A D G Strom, A G D Bean
Early acting cytokines and growth factors such as those of the CD131 βc subunit, may offer an alternative method to the current use of antibiotics and chemicals such as anthelmintics in maintaining Porcine (Po) health. Thus far, the recombinant Po (rPo) Granulocyte-macrophage colony-stimulating factor (GM-CSF), rPo interleukin-3 (IL-3) and rPo interleukin-5 (IL-5) proteins have been identified and cloned and the biological activity of each cytokine has been confirmed in vitro, however, in vivo immune system regulation and hematopoietic stem cell (HSC) augmentation are regulated by numerous cytokines and cellular signals within the bone marrow (BM) niche...
August 11, 2017: Cytokine
https://www.readbyqxmd.com/read/28806996/improved-passive-catheter-tracking-with-positive-contrast-for-cmr-guided-cardiac-catheterization-using-partial-saturation-psat
#17
Mari Nieves Velasco Forte, Kuberan Pushparajah, Tobias Schaeffter, Israel Valverde Perez, Kawal Rhode, Bram Ruijsink, Mazen Alhrishy, Nicholas Byrne, Amedeo Chiribiri, Tevfik Ismail, Tarique Hussain, Reza Razavi, Sébastien Roujol
BACKGROUND: Cardiac catheterization is a common procedure in patients with congenital heart disease (CHD). Although cardiovascular magnetic resonance imaging (CMR) represents a promising alternative approach to fluoroscopy guidance, simultaneous high contrast visualization of catheter, soft tissue and the blood pool remains challenging. In this study, a novel passive tracking technique is proposed for enhanced positive contrast visualization of gadolinium-filled balloon catheters using partial saturation (pSAT) magnetization preparation...
August 15, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28806764/do-labeled-versus-unlabeled-treatments-of-alternatives-names-influence-stated-choice-outputs-results-from-a-mode-choice-study
#18
Wen Jin, Hai Jiang, Yimin Liu, Erica Klampfl
Discrete choice experiments have been widely applied to elicit behavioral preferences in the literature. In many of these experiments, the alternatives are named alternatives, meaning that they are naturally associated with specific names. For example, in a mode choice study, the alternatives can be associated with names such as car, taxi, bus, and subway. A fundamental issue that arises in stated choice experiments is whether to treat the alternatives' names as labels (that is, labeled treatment), or as attributes (that is, unlabeled treatment) in the design as well as the presentation phases of the choice sets...
2017: PloS One
https://www.readbyqxmd.com/read/28806101/homeless-women-s-service-use-barriers-and-motivation-for-participating-in-substance-use-treatment
#19
Carole C Upshur, Darlene Jenkins, Linda Weinreb, Lillian Gelberg, Elizabeth Aaker Orvek
BACKGROUND: Homeless women are at high risk for substance use disorder (SUD), and are a growing proportion of the homeless population. However, homeless women experience barriers to engaging in substance use services. OBJECTIVES: Among homeless women with SUD, to explore service use, motivation to change, service barriers, and willingness to have substance use and mental health problems addressed in primary health care. METHODS: Women with SUD were sampled from 11 Health Care for the Homeless (HCH) primary care clinics in 9 states, yielding 241 with either an alcohol or drug use disorder who then completed questions about SUD services...
August 14, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28806086/role-of-electrostatics-in-protein-rna-binding-the-global-vs-the-local-energy-landscape
#20
Zhaleh Ghaemi, Irisbel Guzman, David Gnutt, Zaida Luthey-Schulten, Martin Gruebele
U1A protein - stem loop 2 RNA association is a basic step in the assembly of the spliceosomal U1 small nuclear ribonucleoprotein. Long-range electrostatic interactions due to the positive charge of U1A are thought to provide high binding affinity for the negatively charged RNA. Short range interactions, such as hydrogen bonds and contacts between RNA bases and protein side chains, favor a specific binding site. Here, we propose that electrostatic interactions are as important as local contacts in biasing the protein-RNA energy landscape towards a specific binding site...
August 14, 2017: Journal of Physical Chemistry. B
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