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https://www.readbyqxmd.com/read/29550449/hiv-care-in-central-and-eastern-europe-how-close-are-we-to-the-target
#1
Deniz Gokengin, Cristiana Oprea, Josip Begovac, Andrzej Horban, Arzu Nazlı Zeka, Dalibor Sedlacek, Bayjanov Allabergan, Esmira A Almamedova, Tatevik Balayan, Denes Banhegyi, Pavlina Bukovinova, Nikoloz Chkhartishvili, Alymbaeva Damira, Edona Deva, Ivaylo Elenkov, Luljeta Gashi, Dafina Gexha-Bunjaku, Vesna Hadciosmanovic, Arjan Harxhi, Tiberiu Holban, Djorje Jevtovic, David Jilich, Justyna Kowalska, Djhamal Kuvatova, Natalya Ladnaia, Adkhamjon Mamatkulov, Aleksandra Marjanovic, Maria Nikolova, Mario Poljak, Kristi Rüütel, Azzaden Shunnar, Milena Stevanovic, Zhanna Trumova, Oleg Yurin
OBJECTIVES: The aim of this survey was to describe the current status of HIV care in Central and Eastern European countries and to look at how close the region is to achieve the UNAIDS 2020 target of 90-90-90. METHODS: In 2014 data were collected from 24 Central and Eastern European countries by a 38-item questionnaire. RESULTS: All countries reported mandatory screening of blood and organ donors for HIV. Other groups who were subjected to targeted screening were people who inject drugs (PWID) (15/24; 62...
March 14, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29522846/a-rab27a-5-untranslated-region-structural-variant-associated-with-late-onset-hemophagocytic-lymphohistiocytosis-and-normal-pigmentation
#2
Bianca Tesi, Jelena Rascon, Samuel C C Chiang, Birute Burnyte, Alexandra Löfstedt, Anders Fasth, Miriam Heizmann, Sandra Juozapaite, Rosita Kiudeliene, Egle Kvedaraite, Valdone Miseviciene, Audrone Muleviciene, Martha-Lena Müller, Magnus Nordenskjöld, Reda Matuzeviciene, Ruta Samaitiene, Carsten Speckmann, Sigita Stankeviciene, Vytautas Zekas, Matthias Voss, Stephan Ehl, Nerija Vaiciene-Magistris, Jan-Inge Henter, Marie Meeths, Yenan T Bryceson
No abstract text is available yet for this article.
March 6, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29393263/new-hydrogels-enriched-with-antioxidants-from-saffron-crocus-can-find-applications-in-wound-treatment-and-or-beautification
#3
Keti Zeka, Ketan C Ruparelia, Claudia Sansone, Guido Macchiarelli, Maria Adelaide Continenza, Randolph R J Arroo
Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. These hydrogels could be considered as new drug delivery system. Hydrogels are crosslinked polymer networks that absorb large quantities of water but retain the properties of a solid, thus making ideal dressings for sensitive skin. We tested antioxidant-enriched hydrogels on primary mouse fibroblasts...
2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29365529/damaging-factors-on-endothelial-cells-affect-circulating-endothelial-microvesicle-count-in-peripheral-blood
#4
Zekas Vytautas, Reda Matuzeviciene, Dovile Karciauskaite, Asta Mazeikiene, Neringa Burokiene, Mantas Radzevicius, Ausra Janiulioniene, Zita Kucinskiene
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29362620/compare-of-the-west-syndrome-with-other-syndromes-in-the-epileptic-encephalopathy-kosovo-experience
#5
Naim Zeka, Abdurrahim Gërguri, Ramush Bejiqi, Ragip Retkoceri, Armend Vuciterna
BACKGROUND: West Syndrome (WS) represents as a specific epileptic encephalopathy characterised with a unique type of attacks, called infantile spasms, severe forms of abnormalities in electroencephalographic (EEG) records as a hypsarythmias and delays in the psychomotoric development. The characteristics of the disease, mostly affecting male gender, are infantile spasms and typical findings in EEG as a hypsarythmia. Infantile spasms are a consequence of many factors in the undeveloped brain...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29362619/kosovo-s-experience-for-children-with-feeding-difficulties-after-cardiac-surgery-for-congenital-heart-defect
#6
Ramush Bejiqi, Ragip Retkoceri, Hana Bejiqi, Arlinda Maloku, Armend Vuçiterna, Naim Zeka, Abdurrahim Gerguri, Rinor Bejiqi
BACKGROUND: A feeding disorder in infancy and during childhood is a complex condition involving different symptoms such as food refusal and faddiest, both leading to a decreased food intake. AIM: We aimed to assess the prevalence and predictor factors of feeding difficulties in children who underwent cardiac open heart surgery in neonatal period and infancy. We address selected nutritional and caloric requirements for children after cardiac surgery and explore nutritional interdependence with other system functions...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29332599/the-synthesis-of-chalcones-as-anticancer-prodrugs-and-their-bioactivation-in-cyp1-expressing-breast-cancer-cells
#7
Ketan C. Ruparelia, Keti Zeka, Taeeba Ijaz, Dyan N. Ankrett, Nicola E. Wilsher, Paul C. Butler, Hoon L. Tan, Sabahat Lodhi, Avninder S. Bhambra, Gerard A. Potter, Randolph R. Arroo, Kenneth J. M. Beresford
BACKGROUND: Although the expression levels of many P450s differ between tumour and corresponding normal tissue, CYP1B1 is one of the few CYP subfamilies which is significantly and consistently overexpressed in tumours. CYP1B1 has been shown to be active within tumours and is capable of metabolising a structurally diverse range of anticancer drugs. Because of this, and its role in the activation of procarcinogens, CYP1B1 is seen as an important target for anticancer drug development. OBJECTIVES: To synthesise a series of chalcone derivatives based on the chemopreventative agent DMU-135 and investigate their antiproliferative activities in human breast cancer cell lines which express CYP1B1 and CYP1A1...
January 12, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29276803/projections-of-temperature-related-excess-mortality-under-climate-change-scenarios
#8
Antonio Gasparrini, Yuming Guo, Francesco Sera, Ana Maria Vicedo-Cabrera, Veronika Huber, Shilu Tong, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Eric Lavigne, Patricia Matus Correa, Nicolas Valdes Ortega, Haidong Kan, Samuel Osorio, Jan Kyselý, Aleš Urban, Jouni J K Jaakkola, Niilo R I Ryti, Mathilde Pascal, Patrick G Goodman, Ariana Zeka, Paola Michelozzi, Matteo Scortichini, Masahiro Hashizume, Yasushi Honda, Magali Hurtado-Diaz, Julio Cesar Cruz, Xerxes Seposo, Ho Kim, Aurelio Tobias, Carmen Iñiguez, Bertil Forsberg, Daniel Oudin Åström, Martina S Ragettli, Yue Leon Guo, Chang-Fu Wu, Antonella Zanobetti, Joel Schwartz, Michelle L Bell, Tran Ngoc Dang, Dung Do Van, Clare Heaviside, Sotiris Vardoulakis, Shakoor Hajat, Andy Haines, Ben Armstrong
Background: Climate change can directly affect human health by varying exposure to non-optimal outdoor temperature. However, evidence on this direct impact at a global scale is limited, mainly due to issues in modelling and projecting complex and highly heterogeneous epidemiological relationships across different populations and climates. Methods: We collected observed daily time series of mean temperature and mortality counts for all causes or non-external causes only, in periods ranging from Jan 1, 1984, to Dec 31, 2015, from various locations across the globe through the Multi-Country Multi-City Collaborative Research Network...
December 2017: Lancet. Planetary Health
https://www.readbyqxmd.com/read/29089167/mortality-burden-of-diurnal-temperature-range-and-its-temporal-changes-a-multi-country-study
#9
Whanhee Lee, Michelle L Bell, Antonio Gasparrini, Ben G Armstrong, Francesco Sera, Sunghee Hwang, Eric Lavigne, Antonella Zanobetti, Micheline de Sousa Zanotti Stagliorio Coelho, Paulo Hilario Nascimento Saldiva, Samuel Osorio, Aurelio Tobias, Ariana Zeka, Patrick G Goodman, Bertil Forsberg, Joacim Rocklöv, Masahiro Hashizume, Yasushi Honda, Yue-Liang Leon Guo, Xerxes Seposo, Do Van Dung, Tran Ngoc Dang, Shilu Tong, Yuming Guo, Ho Kim
Although diurnal temperature range (DTR) is a key index of climate change, few studies have reported the health burden of DTR and its temporal changes at a multi-country scale. Therefore, we assessed the attributable risk fraction of DTR on mortality and its temporal variations in a multi-country data set. We collected time-series data covering mortality and weather variables from 308 cities in 10 countries from 1972 to 2013. The temporal change in DTR-related mortality was estimated for each city with a time-varying distributed lag model...
January 2018: Environment International
https://www.readbyqxmd.com/read/29084393/longer-term-impact-of-high-and-low-temperature-on-mortality-an-international-study-to-clarify-length-of-mortality-displacement
#10
Ben Armstrong, Michelle L Bell, Micheline de Sousa Zanotti Stagliorio Coelho, Yue-Liang Leon Guo, Yuming Guo, Patrick Goodman, Masahiro Hashizume, Yasushi Honda, Ho Kim, Eric Lavigne, Paola Michelozzi, Paulo Hilario Nascimento Saldiva, Joel Schwartz, Matteo Scortichini, Francesco Sera, Aurelio Tobias, Shilu Tong, Chang-Fu Wu, Antonella Zanobetti, Ariana Zeka, Antonio Gasparrini
BACKGROUND: In many places, daily mortality has been shown to increase after days with particularly high or low temperatures, but such daily time-series studies cannot identify whether such increases reflect substantial life shortening or short-term displacement of deaths (harvesting). OBJECTIVES: To clarify this issue, we estimated the association between annual mortality and annual summaries of heat and cold in 278 locations from 12 countries. METHODS: Indices of annual heat and cold were used as predictors in regressions of annual mortality in each location, allowing for trends over time and clustering of annual count anomalies by country and pooling estimates using meta-regression...
October 27, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29070051/human-antibodies-against-the-myelin-oligodendrocyte-glycoprotein-can-cause-complement-dependent-demyelination
#11
Patrick Peschl, Kathrin Schanda, Bleranda Zeka, Katherine Given, Denise Böhm, Klemens Ruprecht, Albert Saiz, Andreas Lutterotti, Kevin Rostásy, Romana Höftberger, Thomas Berger, Wendy Macklin, Hans Lassmann, Monika Bradl, Jeffrey L Bennett, Markus Reindl
BACKGROUND: Antibodies to the myelin oligodendrocyte glycoprotein (MOG) are associated with a subset of inflammatory demyelinating diseases of the central nervous system such as acute disseminated encephalomyelitis and neuromyelitis optica spectrum disorders. However, whether human MOG antibodies are pathogenic or an epiphenomenon is still not completely clear. Although MOG is highly conserved within mammals, previous findings showed that not all human MOG antibodies bind to rodent MOG...
October 25, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28886602/heat-wave-and-mortality-a-multicountry-multicommunity-study
#12
Yuming Guo, Antonio Gasparrini, Ben G Armstrong, Benjawan Tawatsupa, Aurelio Tobias, Eric Lavigne, Micheline de Sousa Zanotti Stagliorio Coelho, Xiaochuan Pan, Ho Kim, Masahiro Hashizume, Yasushi Honda, Yue-Liang Leon Guo, Chang-Fu Wu, Antonella Zanobetti, Joel D Schwartz, Michelle L Bell, Matteo Scortichini, Paola Michelozzi, Kornwipa Punnasiri, Shanshan Li, Linwei Tian, Samuel David Osorio Garcia, Xerxes Seposo, Ala Overcenco, Ariana Zeka, Patrick Goodman, Tran Ngoc Dang, Do Van Dung, Fatemeh Mayvaneh, Paulo Hilario Nascimento Saldiva, Gail Williams, Shilu Tong
BACKGROUND: Few studies have examined variation in the associations between heat waves and mortality in an international context. OBJECTIVES: We aimed to systematically examine the impacts of heat waves on mortality with lag effects internationally. METHODS: We collected daily data of temperature and mortality from 400 communities in 18 countries/regions and defined 12 types of heat waves by combining community-specific daily mean temperature ≥90th, 92...
August 10, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28400190/early-and-mid-term-outcome-of-the-st-jude-medical-regent-19-mm-aortic-valve-mechanical-prosthesis-functional-and-haemodynamic-evaluation
#13
Edvin Prifti, Massimo Bonacchi, Giovanni Minardi, Klodian Krakulli, Arben Baboci, Giampiero Esposito, Aurel Demiraj, Merita Zeka, Edlira Rruci
BACKGROUND AND OBJECTIVES: The aim of the present study is to report the early and mid-term clinical and haemodynamic results of the St Jude Medical Regent 19-mm aortic mechanical prothesis (SJMR-19). MATERIALS AND METHODS: Between January 2002 and January 2012, 265 patients with aortic valve disease underwent AVR (Aortic Valve Replacement) with a SJMR-19 (St Jude Medical Regent Nr.19). There were 51 males. Mean age was 67.5±12.72years and mean body surface area (BSA) was 1...
February 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28397313/correlation-of-cytologic-and-histopathologic-findings-with-perinodal-echogenicity-of-abdominal-lymph-nodes-in-dogs-and-cats
#14
Aditya C Davé, Lisa J Zekas, Danelle M Auld
Abdominal lymphadenopathy in dogs and cats is routinely investigated with ultrasound. As the determination between benign and neoplastic etiologies of lymphadenopathy affects patient management, specific sonographic characteristics associated with both benign and neoplastic lymph nodes have been suggested. However, a significant overlap between these characteristics exists, necessitating a cytologic or histopathologic diagnosis in most instances. The objectives of this retrospective, cross-sectional study were to evaluate whether echogenicity of perinodal fat could be a discriminator between benign and neoplastic abdominal lymphadenopathy and to assess if additional sonographic features associated with malignancy could be identified in lymph nodes with hyperechoic perinodal fat...
July 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28386394/surgical-treatment-of-post-infarction-left-ventricular-pseudoaneurysm-case-series-highlighting-various-surgical-strategies
#15
Edvin Prifti, Massimo Bonacchi, Arben Baboci, Gabriele Giunti, Altin Veshti, Aurel Demiraj, Merita Zeka, Edlira Rruci, Ervin Bejko
INTRODUCTION AND OBJECTIVE: The left ventricular pseudoaneurysm (LVP) is rare, the surgical experience is limited and its surgical treatment remains still a challenge with an elevated mortality. Herein, it is presented a retrospective analysis of our experience with acquired post infarct LVP over a10-year period. MATERIALS AND METHODS: Between January 2006 through August 2016, a total of 13 patients underwent operation for post infarct pseudoaneurysm of the left ventricle...
April 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28344975/equine-dental-pulp-connective-tissue-particles-reduced-lameness-in-horses-in-a-controlled-clinical-trial
#16
Alicia L Bertone, Nathalie A Reisbig, Allison H Kilborne, Mari Kaido, Navid Salmanzadeh, Rebecca Lovasz, Joy L Sizemore, Logan Scheuermann, Rosalind J Kopp, Lisa J Zekas, Matthew T Brokken
OBJECTIVE: To assess if injection of allogeneic dental pulp tissue particles would improve lameness in horses with naturally occurring osteoarthritis (OA) or soft tissue (ST) injury. DESIGN: Prospective, randomized, blinded, and controlled clinical trial and client survey assessment. ANIMALS: Forty lame client-owned horses. PROCEDURES: Sterile dental pulp, recovered from otherwise healthy foals that perish during dystocia, was processed under good manufacturing processing to produce mechanically manipulated, unexpanded pulp tissue particles containing viable cells surrounded in extracellular matrix...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28344667/m%C3%A3-ller-cells-and-retinal-axons-can-be-primary-targets-in-experimental-neuromyelitis-optica-spectrum-disorder
#17
REVIEW
Bleranda Zeka, Hans Lassmann, Monika Bradl
Recent work from our laboratory, using different models of experimental neuromyelitis optica spectrum disorder (NMOSD), has led to a number of observations that might be highly relevant for NMOSD patients. For example: (i) in the presence of neuromyelitis optica immunoglobulin G, astrocyte-destructive lesions can be initiated by CD4+ T cells when these cells recognize aquaporin 4 (AQP4), but also when they recognize other antigens of the central nervous system. The only important prerequisite is that the T cells have to be activated within the central nervous system by "their" specific antigen...
January 2017: Clinical & Experimental Neuroimmunology
https://www.readbyqxmd.com/read/28322521/association-or-causation-in-miasmas-and-mixtures-bradford-hill-and-beyond
#18
Silvia Narduzzi, Roberta Pirastu, Ariana Zeka, Carla Ancona
No abstract text is available yet for this article.
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27503347/aquaporin-4-specific-t-cells-and-nmo-igg-cause-primary-retinal-damage-in-experimental-nmo-sd
#19
Bleranda Zeka, Maria Hastermann, Nathalie Kaufmann, Kathrin Schanda, Marko Pende, Tatsuro Misu, Paulus Rommer, Kazuo Fujihara, Ichiro Nakashima, Charlotte Dahle, Fritz Leutmezer, Markus Reindl, Hans Lassmann, Monika Bradl
Neuromyelitis optica/spectrum disorder (NMO/SD) is a severe, inflammatory disease of the central nervous system (CNS). In the majority of patients, it is associated with the presence of pathogenic serum autoantibodies (the so-called NMO-IgGs) directed against the water channel aquaporin 4 (AQP4), and with the formation of large, astrocyte-destructive lesions in spinal cord and optic nerves. A large number of recent studies using optical coherence tomography (OCT) demonstrated that damage to optic nerves in NMO/SD is also associated with retinal injury, as evidenced by retinal nerve fiber layer (RNFL) thinning and microcystic inner nuclear layer abnormalities...
August 8, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27391909/evaluation-of-a-single-intra-articular-injection-of-autologous-protein-solution-for-treatment-of-osteoarthritis-in-a-canine-population
#20
RANDOMIZED CONTROLLED TRIAL
Audrey W Wanstrath, Bianca F Hettlich, Lillian Su, Ashley Smith, Lisa J Zekas, Matthew J Allen, Alicia L Bertone
OBJECTIVE: To evaluate the safety and efficacy of an intra-articular injection of autologous protein solution (APS) for treatment of canine osteoarthritis (OA). STUDY DESIGN: Prospective, randomized, blinded, placebo-controlled pilot clinical trial. ANIMALS: Client-owned dogs with single limb lameness because of OA in a stifle or elbow joint (n=21). METHODS: Lame dogs, confirmed with OA by physical and lameness examination and imaging, were randomly assigned to control or treatment groups...
August 2016: Veterinary Surgery: VS
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