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Sciatica pain

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https://www.readbyqxmd.com/read/29649547/early-onset-disc-degeneration-in-sm-j-mice-is-associated-with-ion-transport-systems-and-fibrotic-changes
#1
Ying Zhang, Chi Xiong, Mateusz Kudelko, Yan Li, Cheng Wang, Yuk Lun Wong, Vivian Tam, Muhammad Farooq Rai, James Cheverud, Heather A Lawson, Linda Sandell, Wilson C W Chan, Kathryn S E Cheah, Pak C Sham, Danny Chan
Intervertebral disc degeneration (IDD) causes back pain and sciatica, affecting quality of life and resulting in high economic/social burden. The etiology of IDD is not well understood. Along with aging and environmental factors, genetic factors also influence the onset, progression and severity of IDD. Genetic studies of risk factors for IDD using human cohorts are limited by small sample size and low statistical power. Animal models amenable to genetic and functional studies of IDD provide desirable alternatives...
April 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29621243/clinical-diagnostic-model-for-sciatica-developed-in-primary-care-patients-with-low-back-related-leg-pain
#2
Siobhán Stynes, Kika Konstantinou, Reuben Ogollah, Elaine M Hay, Kate M Dunn
BACKGROUND: Identification of sciatica may assist timely management but can be challenging in clinical practice. Diagnostic models to identify sciatica have mainly been developed in secondary care settings with conflicting reference standard selection. This study explores the challenges of reference standard selection and aims to ascertain which combination of clinical assessment items best identify sciatica in people seeking primary healthcare. METHODS: Data on 394 low back-related leg pain consulters were analysed...
2018: PloS One
https://www.readbyqxmd.com/read/29600202/late-and-vague-presentation-of-septic-arthritis-of-hip-in-a-ivdrug-abuser
#3
Anantha Krishnan Raghupathi, Avinash Joshi
Introduction: Septic arthritis of the hip is a rare entity in acute presentation of hip pain in adults. Even though hip is the second most commonly affected joint, adult patients with septic arthritis not related to a surgical procedure represent <0.00001% of total acute admissions. Case Report: We present a 32-year-old female intravenous drug abuser, positive for Hepatitis B and C who had started to inject her femoral veins 2 years ago. She presented with a 10 weeks history of radiating pain in the leg which was full, constant and diffuse in nature with hip stiffness...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29575673/determining-one-year-trajectories-of-low-back-related-leg-pain-in-primary-care-patients-growth-mixture-modelling-of-a-prospective-cohort-study
#4
Reuben O Ogollah, Kika Konstantinou, Siobhán Stynes, Kate M Dunn
OBJECTIVE: The clinical presentation and outcome of patients with back and leg pain in primary care are heterogeneous and may be better understood by identification of homogeneous and clinically meaningful subgroups. Subgroups of patients with different back pain trajectories have been identified, but little is known about the trajectories for patients with back-related leg pain. This study sought to identify distinct leg pain trajectories, and baseline characteristics associated with membership of each group, in primary care patients...
March 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29569696/association-of-rs2228570-polymorphism-of-vitamin-d-receptor-gene-with-lumbar-degenerative-disc-disease
#5
Selçuk Özdoğan, Cumhur Kaan Yaltirik, Seda Güleç Yilmaz, Ayhan Koçak, Turgay Isbir
AIM: Lumbar degenerative disc disease (LDDD) is the most common cause of lower back pain (LBP) and sciatica. The vitamin D receptor (VDR) gene, which is located on chromosome 12 (12q12-q14), was the first gene reported to be potentially related to intervertebral degenerative disc disease risks. We conducted a case-control study of a Turkish population and investigated the association between the VDR gene rs2228570 FokI polymorphism and the development of LDDD. MATERIAL AND METHODS: This was a prospective case-control study that included 45 patients with LDDD and 49 healthy individuals (control group)...
March 11, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29569351/preliminary-clinical-evaluation-of-acupuncture-therapy-in-patients-with-postpartum-sciatica
#6
Bing-Shu He, Yang Li, Tong Gui
INTRODUCTION: This study evaluated clinical outcomes following acupuncture treatment of postpartum sciatica. METHODS: One hundred eleven women with postpartum sciatica were enrolled in an acupuncture group (n = 86) or a control group (n = 25), according to their preference. Participants in the acupuncture group attended acupuncture therapy sessions 3 times a week for 4 weeks, while participants in the control group were assigned to bed rest. Outcome measures included the Roland Disability Questionnaire for sciatica, a visual analog scale for leg pain, and patient-reported perceived recovery...
March 23, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29560295/a-case-of-sciatica-during-labor-due-to-an-occiput-posterior-fetus
#7
Cassandra Wasson, Telianne Chon
A 28-year-old term G3P0020 received an epidural with complete pain relief. Approximately 19 hours after the epidural placement, the pain increased. Sensory levels were rechecked and were bilateral and adequate at T8. Further discussion revealed that the pain was unrelated to her contractions; it was in her buttocks and radiating down the leg. The possibility of the fetus being positioned occiput posterior (OP) was discussed. The patient was placed into knee-chest position with instantaneous relief of her pain...
January 17, 2018: Curēus
https://www.readbyqxmd.com/read/29540281/perioperative-pain-assessment-in-a-14-year-old-boy-with-lumbar-disc-herniation
#8
Catherine E Ferland, Diana-Luk Ye, Jean A Ouellet
This case report illustrates the value of a comprehensive perioperative pain assessment composed of quantitative sensory testing and self-reported measures that highlight the impact of pain experienced by a 14-year-old boy suffering from chronic low back pain and sciatica. Before surgery, the pain assessment revealed inefficient endogenous inhibitory pain control with presence of temporal summation of pain. The severe pain was constant and lasted for 18 months. The patient was in a high-anxiety state, and reported significant functional disability and poor sleep quality...
March 12, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29524857/an-unusual-localization-of-seven-months-delayed-pelvic-lymphocele-following-radical-retropubic-prostatectomy-case-report-and-literature-review
#9
Berk Hazır, Hakan Bahadır Haberal, Devrim Akıncı, Bülent Akdoğan
INTRODUCTION: A pelvic lymphocele is a collection of lymphatic fluid that develops after extensive lymphadenectomies in surgeries such as urological malignancies or renal transplantation. Pelvic lymphoceles may cause complications such as fever, abdominal pain, leg swelling, genital swelling and flank pain. This report summarizes the management of a pelvic lymphocele after open radical retropubic prostatectomy with bilateral lymphadenectomy. PRESENTATION OF CASE: Herein, we present a case in which a pelvic lymphocele developed seven months post-radical open retropubic prostatectomy and through this patient we discussed the lymphocele following radical prostatectomy...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29475577/lumbar-disc-herniation-surgery-with-microdiscectomy-plus-interspinous-stabilization-good-clinical-results-but-failure-to-lower-the-incidence-of-re-operation
#10
REVIEW
Manuel Segura-Trepichio, Antonio Martin-Benlloch, Jose Manuel Montoza-Nuñez, David Candela-Zaplana, Andreu Nolasco
BACKGROUND: Discectomy is sometimes associated with recurrence of disc herniation and pain after surgery. The evidence to use an interspinous dynamic stabilization system (IDSS) in association with disc excision to prevent pain and re-operation, remains controversial. METHODS: Patients (age 18-50 years) presenting with lumbago/sciatica (ICD-10-CM M54.3, M54.4) due to voluminous lumbar disc herniation were eligible for participation. Patients underwent microdiscectomy plus IDSS...
February 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29465329/the-time-course-of-ongoing-activity-during-neuritis-and-following-axonal-transport-disruption
#11
Ieva Satkeviciute, George Goodwin, Geoffrey M Bove, Andrew Dilley
Local nerve inflammation (neuritis) leads to ongoing activity and axonal mechanical sensitivity (AMS) along intact nociceptor axons, and disrupts axonal transport. This phenomenon forms the most feasible cause of radiating pain, such as sciatica. We have previously shown that axonal transport disruption without inflammation or degeneration also leads to AMS, but does not cause ongoing activity at the time point when AMS occurs, despite causing cutaneous hypersensitivity. However, there have been no systematic studies of ongoing activity during neuritis or non-inflammatory axonal transport disruption...
February 21, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29455410/can-patients-with-symptomatic-tarlov-cysts-be-differentiated-from-patients-with-specific-low-back-pain-based-on-comprehensive-history-taking
#12
Maria Anna Hulens, Wim Dankaerts, Ricky Rasschaert, Frans Bruyninckx, Marie-Laure Willaert, Charlotte Vereecke, Greet Vansant
BACKGROUND: Tarlov cysts (TCs) are expanded nerve root sheaths that occur near the dorsal root ganglion and result from increased intraspinal hydrostatic pressure. TCs most frequently affect the lumbosacral plexus and therefore may cause specific symptoms such as perineal pain and neurogenic bladder, bowel, and sphincter problems. It has been estimated that 1% of the population has symptomatic Tarlov cysts (STCs). However, STCs appear to be underdiagnosed, with the pain reported by patients commonly attributed to degenerative alterations seen on MRI...
February 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29439771/osteoporotic-pelvic-fractures
#13
Ludwig Oberkircher, Steffen Ruchholtz, Pol Maria Rommens, Alexander Hofmann, Benjamin Bücking, Antonio Krüger
BACKGROUND: The estimated incidence of osteoporotic pelvic fractures among persons over age 60 in Germany is 224 per 100 000 persons per year, and rising. A number of surgical treatment options are available, but clinical long-term data are lacking. METHODS: This review is based on pertinent publications and guidelines retrieved by a selective literature search, and on the authors' clinical experience. RESULTS: Patients often report one or more relatively trivial traumatic incidents leading up to the fracture...
February 2, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29390461/immediate-relief-of-herniated-lumbar-disc-related-sciatica-by-ankle-acupuncture-a-study-protocol-for-a-randomized-controlled-clinical-trial
#14
Anfeng Xiang, Mingshu Xu, Yan Liang, Jinzi Wei, Sheng Liu
BACKGROUND: Around 90% of sciatica cases are due to a herniated intervertebral disc in the lumbar region. Ankle acupuncture (AA) has been reported to be effective in the treatment of acute nonspecific low back pain. This study aims to evaluate the efficacy of a single session of ankle acupuncture for disc-related sciatica. METHOD: This will be a double-blinded, randomized controlled clinical trial. Patients diagnosed with disc-related sciatica will be randomly divided into 3 parallel groups...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29374352/image-guidance-technologies-for-interventional-pain-procedures-ultrasound-fluoroscopy-and-ct
#15
REVIEW
Dajie Wang
Chronic pain is a common medical condition. Patients who suffer uncontrolled chronic pain may require interventions including spinal injections and various nerve blocks. Interventional procedures have evolved and improved over time since epidural injection was first introduced for low back pain and sciatica in 1901. One of the major contributors in the improvement of these interventions is the advancement of imaging guidance technologies. The utilization of image guidance has dramatically improved the accuracy and safety of these interventions...
January 26, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29361854/double-level-isthmic-spondylolisthesis-treated-with-posterior-lumbar-interbody-fusion-with-cage
#16
DeWei Song, Ming Tang, CanHui Li, DeYong Song, ChangBing Wang, TianHang Xuan
OBJECTIVE: Double-level isthmic spondylolisthesis in the lumbar spine is rare. The authors report on 21 cases of double-level isthmic spondylolisthesis treated by posterior lumbar interbody fusion (PLIF) with cage. PATIENTS AND METHODS: Between 2005 and 2015, twenty-one patients with double-level isthmic spondylolisthesis who underwent posterior lumbar interbody fusion (PLIF) with cage were reviewed retrospectively. The VAS (Visual Analogue Scale) and JOA (Japanese Orthopedic Association) score were used to evaluate preoperative and postoperative clinical outcomes...
January 23, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29349997/-surgical-outcome-of-percutaneous-endoscopic-technique-for-highly-migrated-disc-herniation-via-three-different-approaches
#17
Yi Jiang, Ru-Jun Zuo, Lei Wu, Cheng Huang, Yan Shi, Hua-Wei Song, Yi-Wei Wang, Bin Li
OBJECTIVE: To analyze the clinical effects of percutaneous endoscopic technique via three different approaches for highly migrated lumbar disc herniation. METHODS: The clinical data of 68 patients underwent percutaneous endoscopic technique from June 2011 to June 2014 were retrospectively analyzed. There were 43 males and 25 females, aged from 11 to 77 years old with an average of (42.29±15.92) years. The patients were divided into three groups according to different operative approaches, of them, 45 cases were by transforaminal approach (group A), 15 cases by translaminar approach (group B), and 8 cases by transpedicular approach (group C)...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29319608/novel-approach-to-characterising-individuals-with-low-back-related-leg-pain-cluster-identification-with-latent-class-analysis-and-12-month-follow-up
#18
Siobhán Stynes, Kika Konstantinou, Reuben Ogollah, Elaine M Hay, Kate M Dunn
Traditionally, low back-related leg pain (LBLP) is diagnosed clinically as referred leg pain or sciatica (nerve root involvement). However, within the spectrum of LBLP, we hypothesised that there may be other unrecognised patient subgroups. This study aimed to identify clusters of patients with LBLP using latent class analysis and describe their clinical course. The study population was 609 LBLP primary care consulters. Variables from clinical assessment were included in the latent class analysis. Characteristics of the statistically identified clusters were compared, and their clinical course over 1 year was described...
April 2018: Pain
https://www.readbyqxmd.com/read/29316960/pregabalin-versus-gabapentin-in-the-treatment-of-sciatica-study-protocol-for-a-randomised-double-blind-cross-over-trial-pagpros
#19
Kelvin Robertson, Laurence A G Marshman, Maria Hennessy, Linton Harriss, David Plummer
BACKGROUND: There is currently an absence of high-grade evidence regarding the treatment of chronic sciatica (CS). Whilst gabapentin (GBP) and pregabalin (PGB) are both currently used to treat CS, equipoise exists regarding their individual use. In particular, no head-to-head study of GBP and PGB in CS exists. Despite equipoise, most countries' formulary regulatory authorities typically favour one drug for subsidy over the other. This hinders interchange wherever the favoured drug is either ineffective or not tolerated...
January 9, 2018: Trials
https://www.readbyqxmd.com/read/29295804/-primary-well-differentiated-neuroendocrine-tumor-of-the-filum-terminale-case-report-and-literature-review
#20
Juan Manuel Revuelta Barbero, Anwar Saab Mazzei, Carlos Cotúa Quinteros, Laura de Reina
OBJECTIVE: To present a case of a well-differentiated primary intradural-extramedullary neuroendocrine tumor of the filum terminale and to conduct a literature review. CASE: A 68-years old patient was assessed after presenting lower back pain and sciatica with ineffective pain relief. The patient presented an intradural-extramedullary lumbar lesion arising from the filum terminale, which was partially resected. The pathology diagnosis was a well-differentiated primary neuroendocrine tumor (carcinoid tumor)...
December 30, 2017: Neurocirugía
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