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Sciatica pain

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https://www.readbyqxmd.com/read/29894812/why-are-there-no-drugs-indicated-for-sciatica-the-most-common-chronic-neuropathic-syndrome-of-all
#1
REVIEW
John D Markman, Ralf Baron, Jennifer S Gewandter
Here, we examine the stark contrast between the successes and failures of the clinical development of analgesics for different types of chronic low back pain (CLBP) syndrome over the past three decades. Multiple drugs with differing mechanisms of action have been developed for nonspecific axial-predominant low back syndromes and yet not a single therapy is indicated for any neuropathic low back pain syndrome (e.g., sciatica). Clinician findings have informed the entry criteria for neuropathic low back pain clinical trials, whereas entry criteria of axial CLBP trials have prioritized only patient reports of pain...
June 9, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29886296/intradural-ganglioneuroma-mimicking-lumbar-disc-herniation-case-report
#2
Cristina Barrena López, Beatriz De la Calle García, Rosario Sarabia Herrero
Ganglioneuroma (GN) is a slow-growing tumor originating from the neural crest-derived cells, which form the sympathetic nervous system. These tumors can affect anywhere along the peripheral autonomic ganglion sites, being most commonly found in the mediastinum and retroperitoneum. Spinal GNs are extremely rare and, so far, only 1 case arising from a lumbar nerve root has been reported in English literature. GNs are often asymptomatic, and the majority of them, are found incidentally in healthy subjects. Due to its slow growth, symptoms may result from the compressive effect of the tumor...
June 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29792997/risk-factors-for-low-back-pain-and-sciatica-an-umbrella-review
#3
REVIEW
P Parreira, C Maher, D Steffens, M Hancock, M Ferreira
BACKGROUND: Low back pain (LBP) is a highly prevalent condition and it is associated with significant disability and work absenteeism worldwide. A variety of environmental and individual characteristics have been reported to increase the risk of low back pain (LBP). To our knowledge, there has been no previous attempt to summarise the evidence from existing systematic reviews of risk factors for LBP and/or sciatica PURPOSE: to provide an overview of risk factors for LBP, we completed an umbrella review of the evidence from existing systematic reviews...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29763267/top-20-research-studies-of-2017-for-primary-care-physicians
#4
Mark H Ebell, Roland Grad
Based on systematic surveillance of more than 110 medical journals, 247 studies met criteria as POEMs (patient-oriented evidence that matters) in 2017. Members of the Canadian Medical Association identified 20 of these POEMs as most relevant to practice. This article reviews the clinical questions and bottom-line answers from these studies. Blood pressure should be measured after a period of rest, using a bare arm, and orthostatic blood pressure is more predictive when measured after one minute of standing rather than three minutes...
May 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29739371/effectiveness-of-three-interventions-for-secondary-prevention-of-low-back-pain-in-the-occupational-health-setting-a-randomised-controlled-trial-with-a-natural-course-control
#5
J Rantonen, J Karppinen, A Vehtari, S Luoto, E Viikari-Juntura, M Hupli, A Malmivaara, S Taimela
BACKGROUND: We assessed the effectiveness of three interventions that were aimed to reduce non-acute low back pain (LBP) related symptoms in the occupational health setting. METHODS: Based on a survey (n = 2480; response rate 71%) on LBP, we selected a cohort of 193 employees who reported moderate LBP (Visual Analogue Scale VAS > 34 mm) and fulfilled at least one of the following criteria during the past 12 months: sciatica, recurrence of LBP ≥ 2 times, LBP ≥ 2 weeks, or previous sickness absence...
May 8, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29718065/use-of-multiple-data-sources-for-surveillance-of-work-related-chronic-low-back-pain-and-disc-related-sciatica-in-a-french-region
#6
Natacha Fouquet, Julie Bodin, Emilie Chazelle, Alexis Descatha, Yves Roquelaure
Objectives: To compare the data of the French workers' compensation system (WCS) and three surveillance networks, and to determine the possibility of identifying the industry sectors most in need of programs for prevention of low-back pain (LBP). Methods: This study compared four databases and two types of indicators in a west central region of France: • surveillance of musculoskeletal symptoms in the working population [LBP and disc-related sciatica (DRS) indicators; Cosali study] • surveillance of uncompensated work-related diseases (LBP and DRS indicators) • surveillance of lumbar disc surgery (LDS) in the general population (DRS indicator) • French WCS (disc herniation with radiculopathy caused by vibration or handling of materials; DRS indicator) People aged 20-59 were studied...
April 27, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29713768/is-it-painful-to-be-different-sciatic-nerve-anatomical-variants-on-mri-and-their-relationship-to-piriformis-syndrome
#7
Adam L Bartret, Christopher F Beaulieu, Amelie M Lutz
OBJECTIVES: To investigate the purported relationship between sciatic nerve variant anatomy and piriformis syndrome. METHODS: Over 49 months, 1039 consecutive noncontrast adult hip MRIs were completed for various clinical indications. Repeat and technically insufficient studies were excluded. Radiologists categorized sciatic nerve anatomy into Beaton and Anson anatomical types. Chart review using our institution's cohort search and navigation tool determined the prevalence of the explicit clinical diagnosis of piriformis syndrome (primary endpoint) and sciatica and buttock pain (secondary endpoints)...
April 30, 2018: European Radiology
https://www.readbyqxmd.com/read/29702268/vascular-entrapment-of-both-the-sciatic-and-pudendal-nerves-causing-persistent-sciatica-and-pudendal-neuralgia
#8
Ahmet Kale, Gulfem Basol, Taner Usta, Isa Cam
STUDY OBJECTIVE: To demonstrate the laparoscopic approach to malformed branches of the vessels entrapping the nerves of the sacral plexus. DESIGN: A step-by-step explanation of the surgery using video (educative video) (Canadian Task force classification II). The university's Ethics Committee ruled that approval was not required for this video. SETTING: Kocaeli Derince Education and Research Hospital, Kocaeli, Turkey. PATIENT: A 26-year-old patient who had failed medical therapy and presented with complaints of numbness and burning pain on the right side of her vagina and pain radiating to her lower limbs for a period of approximately 36 months...
April 24, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29649547/early-onset-of-disc-degeneration-in-sm-j-mice-is-associated-with-changes-in-ion-transport-systems-and-fibrotic-events
#9
Ying Zhang, Chi Xiong, Mateusz Kudelko, Yan Li, Cheng Wang, Yuk Lun Wong, Vivian Tam, Muhammad Farooq Rai, James Cheverud, Heather A Lawson, Linda Sandell, Wilson C W Chan, Kathryn S E Cheah, Pak C Sham, Danny Chan
Intervertebral disc degeneration (IDD) causes back pain and sciatica, affecting quality of life and resulting in high economic/social burden. The etiology of IDD is not well understood. Along with aging and environmental factors, genetic factors also influence the onset, progression and severity of IDD. Genetic studies of risk factors for IDD using human cohorts are limited by small sample size and low statistical power. Animal models amenable to genetic and functional studies of IDD provide desirable alternatives...
April 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29621243/clinical-diagnostic-model-for-sciatica-developed-in-primary-care-patients-with-low-back-related-leg-pain
#10
Siobhán Stynes, Kika Konstantinou, Reuben Ogollah, Elaine M Hay, Kate M Dunn
BACKGROUND: Identification of sciatica may assist timely management but can be challenging in clinical practice. Diagnostic models to identify sciatica have mainly been developed in secondary care settings with conflicting reference standard selection. This study explores the challenges of reference standard selection and aims to ascertain which combination of clinical assessment items best identify sciatica in people seeking primary healthcare. METHODS: Data on 394 low back-related leg pain consulters were analysed...
2018: PloS One
https://www.readbyqxmd.com/read/29600202/late-and-vague-presentation-of-septic-arthritis-of-hip-in-a-ivdrug-abuser
#11
Anantha Krishnan Raghupathi, Avinash Joshi
Introduction: Septic arthritis of the hip is a rare entity in acute presentation of hip pain in adults. Even though hip is the second most commonly affected joint, adult patients with septic arthritis not related to a surgical procedure represent <0.00001% of total acute admissions. Case Report: We present a 32-year-old female intravenous drug abuser, positive for Hepatitis B and C who had started to inject her femoral veins 2 years ago. She presented with a 10 weeks history of radiating pain in the leg which was full, constant and diffuse in nature with hip stiffness...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29575673/determining-one-year-trajectories-of-low-back-related-leg-pain-in-primary-care-patients-growth-mixture-modelling-of-a-prospective-cohort-study
#12
Reuben O Ogollah, Kika Konstantinou, Siobhán Stynes, Kate M Dunn
OBJECTIVE: The clinical presentation and outcome of patients with back and leg pain in primary care are heterogeneous and may be better understood by identification of homogeneous and clinically meaningful subgroups. Subgroups of patients with different back pain trajectories have been identified, but little is known about the trajectories for patients with back-related leg pain. This study sought to identify distinct leg pain trajectories, and baseline characteristics associated with membership of each group, in primary care patients...
March 25, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29569696/association-of-rs2228570-polymorphism-of-vitamin-d-receptor-gene-with-lumbar-degenerative-disc-disease
#13
Selçuk Özdoğan, Cumhur Kaan Yaltirik, Seda Güleç Yilmaz, Ayhan Koçak, Turgay Isbir
AIM: Lumbar degenerative disc disease (LDDD) is the most common cause of lower back pain (LBP) and sciatica. The vitamin D receptor (VDR) gene, which is located on chromosome 12 (12q12-q14), was the first gene reported to be potentially related to intervertebral degenerative disc disease risks. We conducted a case-control study of a Turkish population and investigated the association between the VDR gene rs2228570 FokI polymorphism and the development of LDDD. MATERIAL AND METHODS: This was a prospective case-control study that included 45 patients with LDDD and 49 healthy individuals (control group)...
March 11, 2018: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29569351/preliminary-clinical-evaluation-of-acupuncture-therapy-in-patients-with-postpartum-sciatica
#14
Bing-Shu He, Yang Li, Tong Gui
INTRODUCTION: This study evaluated clinical outcomes following acupuncture treatment of postpartum sciatica. METHODS: One hundred eleven women with postpartum sciatica were enrolled in an acupuncture group (n = 86) or a control group (n = 25), according to their preference. Participants in the acupuncture group attended acupuncture therapy sessions 3 times a week for 4 weeks, while participants in the control group were assigned to bed rest. Outcome measures included the Roland Disability Questionnaire for sciatica, a visual analog scale for leg pain, and patient-reported perceived recovery...
March 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29560295/a-case-of-sciatica-during-labor-due-to-an-occiput-posterior-fetus
#15
Cassandra Wasson, Telianne Chon
A 28-year-old term G3P0020 received an epidural with complete pain relief. Approximately 19 hours after the epidural placement, the pain increased. Sensory levels were rechecked and were bilateral and adequate at T8. Further discussion revealed that the pain was unrelated to her contractions; it was in her buttocks and radiating down the leg. The possibility of the fetus being positioned occiput posterior (OP) was discussed. The patient was placed into knee-chest position with instantaneous relief of her pain...
January 17, 2018: Curēus
https://www.readbyqxmd.com/read/29540281/perioperative-pain-assessment-in-a-14-year-old-boy-with-lumbar-disc-herniation
#16
Catherine E Ferland, Diana-Luk Ye, Jean A Ouellet
This case report illustrates the value of a comprehensive perioperative pain assessment composed of quantitative sensory testing and self-reported measures that highlight the impact of pain experienced by a 14-year-old boy suffering from chronic low back pain and sciatica. Before surgery, the pain assessment revealed inefficient endogenous inhibitory pain control with presence of temporal summation of pain. The severe pain was constant and lasted for 18 months. The patient was in a high-anxiety state, and reported significant functional disability and poor sleep quality...
May 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29524857/an-unusual-localization-of-seven-months-delayed-pelvic-lymphocele-following-radical-retropubic-prostatectomy-case-report-and-literature-review
#17
Berk Hazır, Hakan Bahadır Haberal, Devrim Akıncı, Bülent Akdoğan
INTRODUCTION: A pelvic lymphocele is a collection of lymphatic fluid that develops after extensive lymphadenectomies in surgeries such as urological malignancies or renal transplantation. Pelvic lymphoceles may cause complications such as fever, abdominal pain, leg swelling, genital swelling and flank pain. This report summarizes the management of a pelvic lymphocele after open radical retropubic prostatectomy with bilateral lymphadenectomy. PRESENTATION OF CASE: Herein, we present a case in which a pelvic lymphocele developed seven months post-radical open retropubic prostatectomy and through this patient we discussed the lymphocele following radical prostatectomy...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29475577/lumbar-disc-herniation-surgery-with-microdiscectomy-plus-interspinous-stabilization-good-clinical-results-but-failure-to-lower-the-incidence-of-re-operation
#18
Manuel Segura-Trepichio, Antonio Martin-Benlloch, Jose Manuel Montoza-Nuñez, David Candela-Zaplana, Andreu Nolasco
BACKGROUND: Discectomy is sometimes associated with recurrence of disc herniation and pain after surgery. The evidence to use an interspinous dynamic stabilization system (IDSS) in association with disc excision to prevent pain and re-operation, remains controversial. METHODS: Patients (age 18-50 years) presenting with lumbago/sciatica (ICD-10-CM M54.3, M54.4) due to voluminous lumbar disc herniation were eligible for participation. Patients underwent microdiscectomy plus IDSS...
May 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29465329/the-time-course-of-ongoing-activity-during-neuritis-and-following-axonal-transport-disruption
#19
Ieva Satkeviciute, George Goodwin, Geoffrey M Bove, Andrew Dilley
Local nerve inflammation (neuritis) leads to ongoing activity and axonal mechanical sensitivity (AMS) along intact nociceptor axons, and disrupts axonal transport. This phenomenon forms the most feasible cause of radiating pain, such as sciatica. We have previously shown that axonal transport disruption without inflammation or degeneration also leads to AMS, but does not cause ongoing activity at the time point when AMS occurs, despite causing cutaneous hypersensitivity. However, there have been no systematic studies of ongoing activity during neuritis or non-inflammatory axonal transport disruption...
February 21, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29455410/can-patients-with-symptomatic-tarlov-cysts-be-differentiated-from-patients-with-specific-low-back-pain-based-on-comprehensive-history-taking
#20
Maria Anna Hulens, Wim Dankaerts, Ricky Rasschaert, Frans Bruyninckx, Marie-Laure Willaert, Charlotte Vereecke, Greet Vansant
BACKGROUND: Tarlov cysts (TCs) are expanded nerve root sheaths that occur near the dorsal root ganglion and result from increased intraspinal hydrostatic pressure. TCs most frequently affect the lumbosacral plexus and therefore may cause specific symptoms such as perineal pain and neurogenic bladder, bowel, and sphincter problems. It has been estimated that 1% of the population has symptomatic Tarlov cysts (STCs). However, STCs appear to be underdiagnosed, with the pain reported by patients commonly attributed to degenerative alterations seen on MRI...
April 2018: Acta Neurochirurgica
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