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https://www.readbyqxmd.com/read/29655873/media-portrayal-of-prenatal-and-postpartum-marijuana-use-in-an-era-of-scientific-uncertainty
#1
Marian Jarlenski, Jonathan W Koma, Jennifer Zank, Lisa M Bodnar, Jill A Tarr, Judy C Chang
BACKGROUND: Objectives were to characterize how scientific information about prenatal and postpartum marijuana use was presented in online media content, and to assess how media portrayed risks and benefits of such marijuana use. METHODS: We analyzed online media items (n = 316) from March 2015 to January 2017. A codebook was developed to measure media content in 4 domains: scientific studies, information about health and well-being, mode of ingestion, and portrayal of risks and benefits...
April 11, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29655594/no-effect-of-prenatal-vitamin-d-deficiency-on-autism-relevant-behaviours-in-multiple-inbred-strains-of-mice
#2
M Langguth, M Fassin, S Alexander, K M Turner, T H J Burne
Autism Spectrum Disorders (ASD) is a group of neurodevelopmental disorders commonly characterised by verbal and non-verbal communication deficits, impaired social interaction and repetitive, stereotypic behaviours. The aetiology of ASD is most likely a combination of genetic and environmental factors. Epidemiological evidence suggests that prenatal vitamin D deficiency is associated with an increased incidence of ASD. The overall aim of this study was to investigate prenatal vitamin D deficiency on ASD-related behavioural phenotypes in multiple inbred strains of mice...
April 12, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29652985/-mutation-analysis-and-prenatal-diagnosis-for-50-pedigrees-affected-with-duchenne-becker-muscular-dystrophy
#3
Huanzheng Li, Chenyang Xu, Yijian Mao, Jinfang Lu, Yanbao Xiang, Xueqin Xu, Shaohua Tang
OBJECTIVE: To establish individualized prenatal diagnosis program for families affected with Duchenne/Becker muscular dystrophy (DMD/BMD) and different clinical background using a variety of methods. METHODS: Multiplex ligation-dependent probe amplification (MLPA) was performed on 50 patients suspected for DMD/BMD. For single exon deletions of the DMD gene, PCR was used for validating the results. For those without any deletion or duplication, Sanger sequencing was used to screen for DMD gene mutations in the children and their mothers...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29649540/incidence-risk-factors-and-pregnancy-outcomes-of-gestational-diabetes-mellitus-using-one-step-versus-two-step-diagnostic-approaches-a-population-based-cohort-study-in-isfahan-iran
#4
Elham Hosseini, Mohsen Janghorbani, Ashraf Aminorroaya
AIMS: To study the incidence, risk factors, and pregnancy outcomes associated with gestational diabetes mellitus (GDM) diagnosed with one-step and two-step screening approaches. METHODS: 1000 pregnant women who were eligible and consented to participate underwent fasting plasma glucose testing at the first prenatal visit (6-14 weeks). The women free from GDM or overt diabetes were screened at 24-28 weeks using the 50-g glucose challenge test (GCT) followed by 100-g, 3-h oral glucose tolerance test (OGTT) (two-step method)...
April 9, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29648595/progesterone-as-a-postnatal-prophylactic-agent-for-encephalopathy-caused-by-prenatal-hypoxic-ischemic-insult
#5
Yoshimasa Kawarai, Hirokazu Tanaka, Tatsuya Kobayashi, Makio Shozu
Brain damage caused by hypoxic ischemic insult during the perinatal period causes hypoxic ischemic encephalopathies (HIEs). Therapeutic hypothermia is indicated for HIE, but since the therapeutic burden is large for its limited therapeutic effectiveness, another strategy is needed. Progesterone (P4) plays a neuroprotective role through the actions of its metabolite, allopregnanolone (Allo), on P4 receptor, GABA (γ-aminobutyric acid)A receptors or both. We examined the therapeutic potential of P4 using a newborn rat model of HIE...
April 10, 2018: Endocrinology
https://www.readbyqxmd.com/read/29648494/placental-glucocorticoid-receptor-and-11%C3%AE-hydroxysteroid-dehydrogenase-2-recruitment-indicates-impact-of-prenatal-adversity-upon-postnatal-development-in-mice
#6
Moshe Gross, Hava Romi, Yelena Gilimovich, Elyashiv Drori, Albert Pinhasov
Prenatal stress may increase concentrations of maternal glucocorticoids, which restrict fetal growth, with variable impact upon postnatal development. Among key regulators of stress hormone effects are the glucocorticoid receptor (GR) and 11β-hydroxysteroid dehydrogenase-2 (11βHSD2), the enzyme that inactivates glucocorticoid. This study utilized mice selectively bred for social dominance (Dom) or submissiveness (Sub), respectively exhibiting resilience or sensitivity to stress, to test whether stress-induced alterations in placental GR and 11βHSD2 protein expression may mediate divergent effects of prenatal adversity upon postnatal development...
April 12, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29628953/internet-usage-among-pregnant-women-for-seeking-health-information-a-review-article
#7
REVIEW
Marzieh Javanmardi, Mahnaz Noroozi, Firoozeh Mostafavi, Hasan Ashrafi-Rizi
Background: In recent years, the Internet has become one of the most popular sources of health information for users, and pregnant women are no exception. This study aimed to investigate Internet usage among pregnant women for achieving health information on the finding of related studies. Materials and Methods: This review study was conducted by searching databases such as IranMedex, Magiran, Scientific Information Database, Irandoc, PubMed, Science Direct, Cochrane, Google Scholar, and Scopus in December 2016...
March 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29627075/congenital-syphilis
#8
REVIEW
Joshua M Cooper, Pablo J Sánchez
Congenital syphilis remains a major public health problem worldwide, and its incidence is increasing in the United States. This review highlights the ongoing problem of this preventable infection, and discusses vertical transmission and clinical manifestations while providing a practical algorithm for the evaluation and management of infants born to mothers with reactive serologic tests for syphilis. Every case of congenital syphilis must be seen as a failure of our public health system to provide optimal prenatal care to pregnant women, as congenital syphilis can be prevented by early and repeated prenatal serologic screening of mothers and penicillin treatment of infected women, their sexual partners, and their newborn infants...
April 4, 2018: Seminars in Perinatology
https://www.readbyqxmd.com/read/29626747/non-invasive-prenatal-paternity-testing-using-cell-free-fetal-dna-from-maternal-plasma-dna-isolation-and-genetic-marker-studies
#9
REVIEW
Shanshan Zhang, Shuyi Han, Maoxiu Zhang, Yunshan Wang
Invasive prenatal paternity tests can result in miscarriage and congenital malformations; therefore, a non-invasive method of testing is preferable. However, little progress could be made in this field until the introduction of cell-free fetal DNA (cffDNA) in 2009. In this review, two aspects regarding the history and development of non-invasive prenatal paternity testing (NIPAT) are summarized: (1) extraction and enrichment of cffDNA and (2) genetic marker-based studies. Although column-based kits are used widely for NIPAT, some researchers have suggested that an automated method, such as magnetic extraction, generally has a higher cffDNA yield than that of manual column-based extraction; therefore, its popularity might increase in the near future...
April 1, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29626711/non-invasive-prenatal-diagnosis-of-fetal-aneuploidy-using-cell-free-fetal-dna
#10
REVIEW
Barbara Renga
The discovery of cell free fetal DNA in maternal plasma has stimulated a rapid development of non-invasive prenatal testing. The recent advent of massively parallel sequencing has allowed the analysis of circulating cell-free fetal DNA to be performed with unprecedented sensitivity and precision. It is thus expected that plasma DNA-based non invasive prenatal testing will play an increasingly important role in the future of obstetric care. The present review summarizes recent advances in non invasive prenatal testing using cell free fetal DNA...
March 20, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29626710/prenatal-diagnosis-of-wolf-hirschhorn-syndrome-ultrasonography-and-molecular-karyotyping-results
#11
Li Zhen, Shu-Shu Fan, Lv-Yin Huang, Min Pan, Jin Han, Xin Yang, Dong-Zhi Li
OBJECTIVE: To present the experience on prenatal diagnosis of Wolf-Hirschhorn syndrome (WHS) to further delineate the fetal presentation of this syndrome. STUDY DESIGN: This was a retrospective analysis of ten pregnancies with fetal WHS identified by chromosomal microarray (CMA). Clinical data were reviewed for these cases, including maternal demographics, indications for invasive testing, sonographic findings, CMA results and pregnancy outcomes. RESULTS: Three cases were diagnosed at the first trimester because of an increased NT or cystic hygroma...
March 31, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29625861/-targeted-newborn-screening-for-sickle-cell-anemia-sickling-test-emmel-test-boundaries-in-the-prenatal-assessment-in-west-african-area
#12
D A Diallo, A Guindo, B A Touré, Y S Sarro, M Sima, O Tessougué, M A Baraika, P Guindo, M Traoré, M Diallo, A Dorie
BACKGROUND: Newborn screening for sickle cell anemia is necessary in Africa where the disease is more frequent. Hemoglobin electrophoresis is used for screening, but is limited by a high cost and difficult access. Sickling test (Emmel test), which is more affordable and technically more accessible, is often requested for prenatal assessment of pregnant women in West African areas to reserve screening for newborns from mothers in whom the positive sickling test attests the presence of hemoglobin S...
April 3, 2018: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29625215/h3k9-acetylation-of-tph2-involved-in-depression-like-behavior-in-male-but-not-female-juvenile-offspring-rat-induced-by-prenatal-stress
#13
Shaokang Dang, Yong Lu, Qian Su, Tianwei Lin, Xiaoxiao Zhang, Huiping Zhang, Junli Zhang, Lin Zhang, Zhongliang Zhu, Hui Li
Increasing evidence has shown that prenatal stress (PS) could cause depression-like behavior in the offspring, which is sex-specific. However, the underlying mechanisms remain to be elucidated. This study is to investigate the involvement of tryptophan hydroxylase 2 (Tph2) H3K9 acetylation (H3K9ac) modification on PS-induced depression-like behavior in juvenile offspring rats (JOR). PS models were established, with or without trichostatin A (TSA) treatment. Animal behavior was assessed by the sucrose preference test (SPT) and forced swimming test (FST)...
April 3, 2018: Neuroscience
https://www.readbyqxmd.com/read/29625197/a-single-subconvulsant-dose-of-domoic-acid-at-mid-gestation-does-not-cause-temporal-lobe-epilepsy-in-mice
#14
Fanny Demars, Kristen Clark, Megan S Wyeth, Emily Abrams, Paul S Buckmaster
Harmful blooms of domoic acid (DA)-producing algae are a problem in oceans worldwide. DA is a potent glutamate receptor agonist that can cause status epilepticus and in survivors, temporal lobe epilepsy. In mice, one-time low-dose in utero exposure to DA was reported to cause hippocampal damage and epileptiform activity, leading to the hypothesis that unrecognized exposure to DA from contaminated seafood in pregnant women can damage the fetal hippocampus and initiate temporal lobe epileptogenesis. However, development of epilepsy (i...
April 3, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29622066/-preimplantation-genetic-diagnosis
#15
Hans Jakob Ingerslev, Birte Degn, Christina Hnida, Tue Diemer, Michael Bjørn Petersen, Tine Nørregaard Olesen, Henrik Krarup, Inge Søkilde Pedersen
In Denmark, preimplantation genetic diagnosis (PGD) is offered within the public healthcare to families with a known risk of an inherited disease in a child - as an alternative to prenatal diagnosis. It is a well-established technique with rather well-described perinatal- and neonatal outcomes, being comparable to what is seen following in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). The most common strategy is now to perform trophectoderm biopsy and then vitrify, while the diagnostic test is performed...
April 2, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29619771/a-study-of-triplet-primed-pcr-for-identification-of-cag-repeat-expansion-in-the-htt-gene-in-a-cohort-of-503-indian-cases-with-huntington-s-disease-symptoms
#16
Pratiksha Chheda, Milind Chanekar, Yogita Salunkhe, Tavisha Dama, Anurita Pais, Shailesh Pande, Rajesh Bendre, Nilesh Shah
BACKGROUND: Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder with an average age at onset of 40 years. It is a polyglutamine (polyQ) disorder that is caused by an increase in the number of CAG repeats in the huntingtin (HTT) gene. Genetic tests that accurately determine the number of CAG repeats are performed for confirmation of diagnosis, predictive testing of persons at genetic risk for inheriting HD, and prenatal testing. The aim of our study was to evaluate efficacy of triplet-primed polymerase chain reaction (TP-PCR) for routine diagnosis of HD in suspected cases from India...
April 4, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29618930/symptoms-associated-with-attention-deficit-hyperactivity-disorder-and-autism-spectrum-disorders-in-school-aged-children-prenatally-exposed-to-substances
#17
Lisbeth Beate Sandtorv, Silje Katrine Elgen Fevang, Sondre Aasen Nilsen, Tormod Bøe, Rolf Gjestad, Siren Haugland, Irene Bircow Elgen
Prenatal exposure to substances may influence a child's neurodevelopment and impact on subsequent mental health. In a hospital-based population of school-aged children prenatally exposed to opiates and a number of illicit substances (n = 57), we evaluated mental health symptoms associated with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) using the Swanson, Nolan, and Pelham Questionnaire, revision IV (SNAP-IV) and the Autism Spectrum Screening Questionnaire (ASSQ) and compared the scores to a reference group which comprised children from the population-based Bergen Child Study (n = 171)...
2018: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/29618827/niptmer-rapid-k-mer-based-software-package-for-detection-of-fetal-aneuploidies
#18
Martin Sauk, Olga Žilina, Ants Kurg, Eva-Liina Ustav, Maire Peters, Priit Paluoja, Anne Mari Roost, Hindrek Teder, Priit Palta, Nathalie Brison, Joris R Vermeesch, Kaarel Krjutškov, Andres Salumets, Lauris Kaplinski
Non-invasive prenatal testing (NIPT) is a recent and rapidly evolving method for detecting genetic lesions, such as aneuploidies, of a fetus. However, there is a need for faster and cheaper laboratory and analysis methods to make NIPT more widely accessible. We have developed a novel software package for detection of fetal aneuploidies from next-generation low-coverage whole genome sequencing data. Our tool - NIPTmer - is based on counting pre-defined per-chromosome sets of unique k-mers from raw sequencing data, and applying linear regression model on the counts...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29618382/hyperparasitaemia-during-clinical-malaria-episodes-in-infants-aged-0-24-months-and-its-association-with-in-utero-exposure-to-plasmodium-falciparum
#19
Boniphace Sylvester, Dinah B Gasarasi, Said Aboud, Donath Tarimo, Siriel Massawe, Rose Mpembeni, Gote Swedberg
OBJECTIVE: Existing information has shown that infants who are prenatally exposed to P. falciparum are susceptible to subsequent malaria infections. However, the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes has not been fully elucidated. This study is a component of a prospective cohort study for which initial results have been published. This component was designed to determine the effect of prenatal exposure to P. falciparum on parasite density during clinical malaria episodes in the first 24 months of life...
April 4, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29617477/-social-practices-in-the-medicalization-and-humanization-of-prenatal-care
#20
Cristine Maria Warmling, Ananyr Porto Fajardo, Dagmar Estermann Meyer, Cristophe Bedos
The study's main objective is to analyze how discourses of medicalization and humanization reconnect in primary healthcare and shape prenatal care for pregnant women provided by family health teams. This was a single and integrated case study with multiple analytical units and a qualitative approach. A total of 17 focus groups were performed, in which 47 health professionals were heard (14 physicians, 19 nurses, and 14 dentists), members of 17 family health teams in 16 municipalities in the South of Brazil...
March 29, 2018: Cadernos de Saúde Pública
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