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Chronic psychosocial stress

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https://www.readbyqxmd.com/read/28629716/psychosocial-factors-musculoskeletal-disorders-and-work-related-fatigue-amongst-nurses-in-brunei-structural-equation-model-approach
#1
Hanif Abdul Rahman, Khadizah Abdul-Mumin, Lin Naing
INTRODUCTION: Psychosocial factors, musculoskeletal disorders and work-related fatigue have adverse effects on individual nurses and place a substantial financial burden on health care. Evidence of an association has been reported in the literature, but no theoretical explanation has been published to date. AIM: To explore and develop a structural model to provide a theoretical explanation for this relationship. METHODS: A cross-sectional study using data from 201 valid samples of emergency and critical care nurses across public hospitals in Brunei was performed via self-administered questionnaire...
June 16, 2017: International Emergency Nursing
https://www.readbyqxmd.com/read/28624868/how-does-cytomegalovirus-factor-into-diseases-of-aging-and-vaccine-responses-and-by-what-mechanisms
#2
REVIEW
Allison E Aiello, Yen-Ling Chiu, Daniela Frasca
Cytomegalovirus (CMV) is an important pathogen for both clinical and population settings. There is a growing body of research implicating CMV in multiple health outcomes across the life course. At the same time, there is mounting evidence that individuals living in poverty are more likely to be exposed to CMV and more likely to experience many of the chronic conditions for which CMV has been implicated. Further research on the causal role of CMV for health and well-being is needed. However, the strong evidence implicating CMV in type 2 diabetes, autoimmunity, cancer, cardiovascular disease, vaccination, and age-related alterations in immune function warrants clinical and public health action...
June 18, 2017: GeroScience
https://www.readbyqxmd.com/read/28606749/cardiovascular-disease-in-systemic-lupus-erythematosus-a-comprehensive-update
#3
REVIEW
Mayra Giannelou, Clio P Mavragani
Heightened rates of both cardiovascular (CV) events and subclinical atherosclerosis, documented by imaging and vascular function techniques are well established in systemic lupus erythematosus (SLE). While traditional CV factors such as smoking, dyslipidemia, diabetes mellitus (DM), hypertension, central obesity and hyperhomocysteinemia have been reported to be prevalent in lupus patients, they do not fully explain the high rates of ischemic events so far reported, implying that other factors inherent to disease itself could account for the enhanced risk, including disease duration, activity and chronicity, psychosocial factors, medications, genetic variants and altered immunological mechanisms...
June 9, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28599145/telomere-length-in-alcohol-dependence-a-role-for-impulsive-choice-and-childhood-maltreatment
#4
Jee In Kang, Syung Shick Hwang, Jong Rak Choi, Seung-Tae Lee, Jieun Kim, In Sik Hwang, Hae Won Kim, Chan-Hyung Kim, Se Joo Kim
Telomere shortening, a marker of cellular aging, has been considered to be linked with psychosocial stress as well as with chronic alcohol consumption, possibly mediated by oxidative stress and inflammatory response. Recent findings suggested that early life adversity on telomere dynamics may be related to impulsive choice. To further our understanding of the association of impulsive choice and childhood trauma on telomere length, we examined whether delayed discounting and childhood trauma or their interaction is related to leukocyte telomere length, while controlling for multiple potential confounding variables, in patients with alcohol dependence who are considered to have higher impulsive choice and shorter telomere length...
May 31, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28595325/maternal-lifetime-stress-and-prenatal-psychological-functioning-are-associated-with-decreased-placental-mitochondrial-dna-copy-number-in-the-prism-study
#5
Kelly J Brunst, Marco Sanchez Guerra, Chris Gennings, Michele Hacker, Calvin Jara, Michelle Bosquet Enlow, Robert O Wright, Andrea Baccarelli, Rosalind J Wright
Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to oxidative stress which can lead to changes in mitochondrial DNA copy number (mtDNAcn). We examined associations between maternal lifetime stress, current negative life events, depressive and posttraumatic stress disorder symptom scores and placental mtDNAcn in a racially/ethnically diverse sample (N = 147) from the PRogramming of Intergenerational Stress Mechanisms study (March 2011- August 2012). In linear regression analyses adjusted for maternal age, race/ethnicity, education, prenatal fine particulate matter, prenatal smoking, and child sex, all measures of stress were associated with decreased placental mtDNAcn (all P-values < 0...
June 8, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28595276/premorbid-iq-predicts-postconcussive-symptoms-in-oef-oif-ond-veterans-with-mtbi
#6
Jada J Stewart-Willis, Daniel Heyanka, Zoe Proctor-Weber, Heather England, Maya Bruhns
Objective: Extant literature has demonstrated that symptoms of postconcussive syndrome (PCS) persist well beyond the expected 3-month post-injury recovery period in a minority of individuals with mild traumatic brain injury (mTBI). Suboptimal performance on validity measures and pre- and post-injury psychosocial stressors - rather than actual mTBI or current cognitive functioning - have been identified as predictors of chronic PCS. Whether premorbid IQ has any influence on chronic PCS has been understudied, in the context of established psychogenic etiologies...
June 8, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28594600/psychosocial-and-environmental-factors-in-the-prognosis-of-individuals-with-chronic-pain-and-comorbid-mental-health
#7
Valerie Hruschak, Gerald Cochran
Chronic pain has considerable medical, social, and economic implications as its high prevalence rate and negative societal burden provides justification that it is a major health issue. The value of understanding psychological, social, and environmental factors in chronic pain has become widely recognized and accepted as a biopsychosocial phenomenon in which the social work perspective offers a valuable lens. Through the critical application of systems theory and ecological perspective, accompanied with the diathesis stress model, this article examines psychosocial and environmental influences as being contributory factors in the prognosis of individuals with chronic pain and comorbid mental health disorders...
June 8, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28593903/hippocampal-bdnf-in-physiological-conditions-and-social-isolation
#8
Ivan Zaletel, Dragana Filipović, Nela Puškaš
Exposure of an organism to chronic psychosocial stress may affect brain-derived neurotrophic factor (BDNF) expression that has been implicated in the etiology of psychiatric disorders, such as depression. Given that depression in humans has been linked with social stress, the chronic social stress paradigms for modeling psychiatric disorders in animals have thus been developed. Chronic social isolation in animal models generally causes changes in hypothalamic-pituitary-adrenal axis functioning, associated with anxiety- and depressive-like behaviors...
April 7, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28585928/predicting-attention-deficit-hyperactivity-disorder-severity-from-psychosocial-stress-and-stress-response-genes-a-random-forest-regression-approach
#9
D van der Meer, P J Hoekstra, M van Donkelaar, J Bralten, J Oosterlaan, D Heslenfeld, S V Faraone, B Franke, J K Buitelaar, C A Hartman
Identifying genetic variants contributing to attention-deficit/hyperactivity disorder (ADHD) is complicated by the involvement of numerous common genetic variants with small effects, interacting with each other as well as with environmental factors, such as stress exposure. Random forest regression is well suited to explore this complexity, as it allows for the analysis of many predictors simultaneously, taking into account any higher-order interactions among them. Using random forest regression, we predicted ADHD severity, measured by Conners' Parent Rating Scales, from 686 adolescents and young adults (of which 281 were diagnosed with ADHD)...
June 6, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28585474/family-experience-with-osteogenesis-imperfecta-type-1-the-most-distressing-situations
#10
Margarida Custódio Dos Santos, Ana Filipa Pires, Kelly Soares, Luísa Barros
BACKGROUND: Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by decreased bone mass and increased bone fragility. Despite increasing research on the biomedical aspects of the disease, only a few studies focus on the psychosocial implications of living with OI. This study aimed to explore the situations that are perceived by OI type-1 children, their parents and siblings, as being the most distressing and stressful in their experience with the disease. METHODS: Seven families of children diagnosed with OI type 1 for longer than four years participated...
June 6, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28578301/diurnal-cortisol-slopes-and-mental-and-physical-health-outcomes-a-systematic-review-and-meta-analysis
#11
REVIEW
Emma K Adam, Meghan E Quinn, Royette Tavernier, Mollie T McQuillan, Katie A Dahlke, Kirsten E Gilbert
Changes in levels of the stress-sensitive hormone cortisol from morning to evening are referred to as diurnal cortisol slopes. Flatter diurnal cortisol slopes have been proposed as a mediator between chronic psychosocial stress and poor mental and physical health outcomes in past theory and research. Surprisingly, neither a systematic nor a meta-analytic review of associations between diurnal cortisol slopes and health has been conducted to date, despite extensive literature on the topic. The current systematic review and meta-analysis examined associations between diurnal cortisol slopes and physical and mental health outcomes...
May 24, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28567696/blunted-stress-reactivity-in-chronic-cannabis-users
#12
Carrie Cuttler, Alexander Spradlin, Amy T Nusbaum, Paul Whitney, John M Hinson, Ryan J McLaughlin
RATIONALE: One of the most commonly cited reasons for chronic cannabis use is to cope with stress. Consistent with this, cannabis users have shown reduced emotional arousal and dampened stress reactivity in response to negative imagery. OBJECTIVES: To our knowledge, the present study represents the first to examine the effects of an acute stress manipulation on subjective stress and salivary cortisol in chronic cannabis users compared to non-users. METHODS: Forty cannabis users and 42 non-users were randomly assigned to complete either the stress or no stress conditions of the Maastricht Acute Stress Test (MAST)...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28558479/mechanisms-of-mitochondrial-redox-signaling-in-psychosocial-stress-responsive-systems-new-insights-into-an-old-story
#13
Thomas Meyer, Petra H Wirtz
SIGNIFICANCE: Psychosocial stress is associated with alterations in serum glucocorticoids and cytokines, such as interleukin-6 (IL-6) and IL-1β, which functionally interact. However, the molecular mechanisms and physiological relationship between the two systems within the context of stress exposure are not well characterized. Recent Advances: Extracellular IL-6, which stimulates the release of cortisol from the zona fasciculata of the adrenal cortex, mediates its intracellular effects by tyrosine phosphorylation of the transcription factor STAT3 (signal transducer and activator of transcription 3)...
May 30, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28554369/effects-and-mediators-of-psychosocial-work-characteristics-on-somatic-symptoms-six-years-later-prospective-findings-from-the-mannheim-industrial-cohort-studies-mics
#14
Raphael M Herr, Jian Li, Adrian Loerbroks, Peter Angerer, Johannes Siegrist, Joachim E Fischer
OBJECTIVE: Ample evidence documented the adverse health effects of work stressors, and recent research has increasingly focused on somatic symptoms which are very common and costly. Prospective evidence is however sparse and yielded mixed findings. Furthermore, there is reason to assume that depression and anxiety might mediate the effects of adverse psychosocial work conditions on somatic symptoms. This study aimed to investigate longitudinal effects of work stressors on somatic symptoms and the potential mediation by anxiety and/or depression...
July 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28553136/chronic-stress-moderates-the-impact-of-social-exclusion-on-pain-tolerance-an-experimental-investigation
#15
Karoline Pieritz, Sarina J Schäfer, Jana Strahler, Winfried Rief, Frank Euteneuer
BACKGROUND: Experiences of social pain due to social exclusion may be processed in similar neural systems that process experiences of physical pain. The present study aimed to extend the findings on social exclusion and pain by examining the impact of social exclusion on an affective (ie, heat pain tolerance) and a sensory component of pain (ie, heat pain intensity). Whether a potential effect may be moderated by chronic life stress, social status, or social sup-port was further examined...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28549747/increased-dipeptidyl-peptidase-4-accelerates-diet-related-vascular-aging-and-atherosclerosis-in-apoe-deficient-mice-under-chronic-stress
#16
Yanna Lei, Guang Yang, Lina Hu, Limei Piao, Aiko Inoue, Haiying Jiang, Takeshi Sasaki, Guangxian Zhao, Maimaiti Yisireyili, Chenglin Yu, Wenhu Xu, Kyosuke Takeshita, Kenji Okumura, Masafumi Kuzuya, Xian Wu Cheng
OBJECTIVES: Exposure to psychosocial stress is a risk factor for cardiovascular disease. Given that dipeptidyl peptidase-4 (DPP4) regulates several intracellular signaling pathways associated with glucagon-like peptide-1 (GLP-1) metabolism, we investigated the role of DPP4 in stress-related vascular senescence and atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice. METHODS AND RESULTS: ApoE(-/-) mice fed a high-fat (HF) diet were randomly assigned to one of non-stress and immobilized stress groups for 12weeks...
May 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28549268/modulation-of-hpa-axis-response-to-social-stress-in-schizophrenia-by-childhood-trauma
#17
Claudia Lange, Christian G Huber, Daniela Fröhlich, Stefan Borgwardt, Undine E Lang, Marc Walter
HPA axis functioning plays an important role in the etiology of schizophrenia spectrum disorders (SSD). However, only few studies have examined HPA axis responsivity to psychosocial stress in SSD, and results are heterogeneous. Furthermore, childhood trauma is known to influence psychopathology and treatment outcome in SSD, but studies on the influence of childhood trauma on stress related HPA axis activity are missing. The purpose of this study was to investigate cortisol response to a psychosocial stress challenge in SSD patients, and to examine its association with severity of childhood trauma...
May 20, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28545792/living-alone-and-activation-of-the-renin-angiotensin-aldosterone-system-differential-effects-depending-on-alexithymic-personality-features
#18
Jan Terock, Anke Hannemann, Deborah Janowitz, Henry Völzke, Matthias Nauck, Harald-Jürgen Freyberger, Henri Wallaschofski, Hans Jörgen Grabe
OBJECTIVE: Living alone is considered as a chronic stress factor predicting different health conditions and particularly cardiovascular disease (CVD). Alexithymia is associated with increased psychological distress, less social skills and fewer close relationships, making alexithymic subjects particularly susceptible to chronic stress imposed by "living alone". Only few studies investigated the renin-angiotensin-aldosterone-system (RAAS) activity in response to chronic stress. We aimed at evaluating the effects of "living alone" as a paradigm for chronic stress on RAAS activity and putatively differential effects depending on alexithymic personality features...
May 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28542024/omega-6-omega-3-pufa-ratio-pain-functioning-and-distress-in-adults-with-knee-pain
#19
Kimberly T Sibille, Christopher King, Timothy J Garrett, Toni L Glover, Hang Zhang, Huaihou Chen, Divya Reddy, Burel R Goodin, Adriana Sotolongo, Megan E Petrov, Yenisel Cruz-Almeida, Matthew Herbert, Emily J Bartley, Jeffrey C Edberg, Roland Staud, David T Redden, Laurence A Bradley, Roger B Fillingim
OBJECTIVES: Osteoarthritis (OA) is associated with inflammation, chronic pain, functional limitations, and psychosocial distress. High Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are associated with lower levels of inflammatory mediators, anti-nociception, and adaptive cognitive/emotional functioning. High Omega-6 (n-6) PUFAs are associated with inflammation, nociception, and psychological distress. While findings related to n-3 supplementation in knee OA are mixed, consideration of the n-6:n-3 ratio and additional outcome measures may provide improved understanding of the potential relevance of these fatty acids in OA...
May 24, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28541239/psychological-parameters-of-psoriasis
#20
A Kouris, E Platsidaki, C Kouskoukis, C Christodoulou
Psoriasis is a chronic, inflammatory scaling dermatosis. The marked visible appearance of the lesions have a negative impact on body image that leads to decreased self-esteem, hence seriously compromising the patient's quality of life. The clinical picture critically affects the social well-being of the patient since the disease is commonly misunderstood and feared by the social environment as being contagious. The patient feels stigmatized and this further intensifies their lack of self-confidence and self-esteem...
January 2017: Psychiatrikē, Psychiatriki
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