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https://www.readbyqxmd.com/read/29141209/high-throughput-drug-screening-identifies-pazopanib-and-clofilium-tosylate-as-promising-treatments-for-malignant-rhabdoid-tumors
#1
Céline Chauvin, Amaury Leruste, Arnault Tauziede-Espariat, Mamy Andrianteranagna, Didier Surdez, Aurianne Lescure, Zhi-Yan Han, Elodie Anthony, Wilfrid Richer, Sylvain Baulande, Mylène Bohec, Sakina Zaidi, Marie-Ming Aynaud, Laetitia Maillot, Julien Masliah-Planchon, Stefano Cairo, Sergio Roman-Roman, Olivier Delattre, Elaine Del Nery, Franck Bourdeaut
Rhabdoid tumors (RTs) are aggressive tumors of early childhood characterized by SMARCB1 inactivation. Their poor prognosis highlights an urgent need to develop new therapies. Here, we performed a high-throughput screening of approved drugs and identified broad inhibitors of tyrosine kinase receptors (RTKs), including pazopanib, and the potassium channel inhibitor clofilium tosylate (CfT), as SMARCB1-dependent candidates. Pazopanib targets were identified as PDGFRα/β and FGFR2, which were the most highly expressed RTKs in a set of primary tumors...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29136936/analysis-of-a-bio-electrochemical-reactor-containing-carbon-fiber-textiles-for-the-anaerobic-digestion-of-tomato-plant-residues
#2
Shin-Ichi Hirano, Norio Matsumoto
A bio-electrochemical system packed with supporting material can promote anaerobic digestion for several types of organic waste. To expand the target organic matters of a BES, tomato plant residues (TPRs), generated year-round as agricultural and cellulosic waste, were treated using three methanogenic reactors: a continuous stirred tank reactor (CSTR), a carbon fiber textile (CFT) reactor, and a bio-electrochemical reactor (BER) including CFT with electrochemical regulation (BER + CFT). CFT had positive effects on methane fermentation and methanogen abundance...
November 3, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29125094/inferring-individual-cow-effects-dairy-system-effects-and-feeding-effects-on-latent-variables-underlying-milk-protein-composition-and-cheese-making-traits-in-dairy-cattle
#3
Christos Dadousis, Claudio Cipolat-Gotet, Stefano Schiavon, Giovanni Bittante, Alessio Cecchinato
We examined the latent structure of 26 cheese related phenotypes in dairy cattle. Traits related to milk yield and quality (8 traits), milk protein fractions (8 traits), coagulation and curd firmness indicators (CF, 5 traits) and cheese-making phenotypes (cheese yields (%CY) and nutrient recoveries in the curd (REC), 5 traits) were analysed through multivariate factor analysis (MFA) using a varimax rotation. All phenotypes were measured in 1264 Brown Swiss cows. Ten mutual orthogonal, latent variables (factors; Fs) were obtained explaining 74% of the original variability...
November 10, 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/29099206/free-quantum-fields-in-4d-and-calabi-yau-spaces
#4
Robert de Mello Koch, Phumudzo Rabambi, Randle Rabe, Sanjaye Ramgoolam
We develop general counting formulas for primary fields in free four dimensional (4D) scalar conformal field theory (CFT). Using a duality map between primary operators in scalar field theory and multivariable polynomial functions subject to differential constraints, we identify a sector of holomorphic primary fields corresponding to polynomial functions on a class of permutation orbifolds. These orbifolds have palindromic Hilbert series, which indicates they are Calabi-Yau orbifolds. We construct the unique top-dimensional holomorphic form expected from the Calabi-Yau property...
October 20, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29089145/the-empirical-status-of-the-third-wave-behaviour-therapies-for-the-treatment-of-eating-disorders-a-systematic-review
#5
REVIEW
Jake Linardon, Christopher G Fairburn, Ellen E Fitzsimmons-Craft, Denise E Wilfley, Leah Brennan
Although third-wave behaviour therapies are being increasingly used for the treatment of eating disorders, their efficacy is largely unknown. This systematic review and meta-analysis aimed to examine the empirical status of these therapies. Twenty-seven studies met full inclusion criteria. Only 13 randomized controlled trials (RCT) were identified, most on binge eating disorder (BED). Pooled within- (pre-post change) and between-groups effect sizes were calculated for the meta-analysis. Large pre-post symptom improvements were observed for all third-wave treatments, including dialectical behaviour therapy (DBT), schema therapy (ST), acceptance and commitment therapy (ACT), mindfulness-based interventions (MBI), and compassion-focused therapy (CFT)...
December 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29082677/predictive-value-of-baseline-biochemical-parameters-for-clinical-response-of-macular-edema-to-bevacizumab-in-eyes-with-central-retinal-vein-occlusion-a-retrospective-analysis
#6
V G Madanagopalan, Bibha Kumari
PURPOSE: To evaluate the influence of baseline biochemical parameters on the improvement in best corrected visual acuity (BCVA) and reduction in central foveal thickness (CFT) in patients treated with intravitreal bevacizumab (IVB; Avastin, Genentech, Inc) for macular edema (ME) secondary to central retinal vein occlusion (CRVO). DESIGN: A retrospective study. METHODS: Seventy eyes of 70 participants with CRVO who underwent IVB for ME and had at least 1 month of follow-up after the last injection were studied...
October 30, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29081243/evaluation-of-between-within-and-day-to-day-variation-of-coagulation-measured-by-rotational-thrombelastometry-rotem
#7
Petra Jilma-Stohlawetz, Susanne Fritsche-Polanz, Peter Quehenberger, Christian Schörgenhofer, Johann Bartko, Robin Ristl, Bernd Jilma
BACKGROUND AND AIMS: The aim of this study was to assess the circadian variation and the between- and within-subject variation in 10 healthy subjects over a period of 8 weeks by ROTEM(®). We further evaluated the influence of elevated body mass index and the effect of low molecular weight heparin and antithrombin on clot formation. METHODS: Citrated blood samples were analysed in the NATEM(®) test system. The clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF) and the maximum lysis (ML) were assessed...
October 28, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29081148/-follow-up-of-resting-state-brain-function-with-magnetic-resonance-imaging-in-patients-with-type-2-diabetes-mellitus
#8
N Qi, Y Cui, J C Liu, M Yu, G J Teng
Objective: To investigate the changes of resting brain function with time in patients with type 2 diabetes mellitus (T2DM) by using regional homogeneity (ReHo) with resting-state functional magnetic resonance imaging (rs-fMRI). Methods: Multidimensional cognitive function tests and rs-fMRI scans were performed in 21 T2DM patients and 12 healthy controls in 2012 and 2015 respectively.The differences in clinical variables and the ReHo values before and after were measured by paired sample t test, and the correlation between the change of ReHo value and the change of clinical variables was measured by Pearson correlation analysis based on voxel...
October 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29077191/pegaptanib-choroidal-neovascularization-in-patients-with-age-related-macular-degeneration-and-previous-arterial-thromboembolic-events
#9
Maurizio Battaglia Parodi, Emanuele Di Bartolo, Claudia Brue, Ezio Cappello, Claudio Furino, Sebastiano Giuffrida, Manuela Imparato, Michele Reibaldi
PURPOSE: To evaluate the efficacy and the rate of side effects of the pegylated aptamer pegaptanib in the treatment of patients with choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and a history of previous arterial thromboembolic events (ATEs). METHODS: Twenty-three eyes of 23 patients with subfoveal CNV due to AMD and cerebrovascular accidents (n = 12) and myocardial infarction (n = 11) in the previous 6 months received intravitreal pegaptanib 0...
October 25, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29053298/hyperinvariant-tensor-networks-and-holography
#10
Glen Evenbly
We propose a new class of tensor network state as a model for the AdS/CFT correspondence and holography. This class is demonstrated to retain key features of the multiscale entanglement renormalization ansatz (MERA), in that they describe quantum states with algebraic correlation functions, have free variational parameters, and are efficiently contractible. Yet, unlike the MERA, they are built according to a uniform tiling of hyperbolic space, without inherent directionality or preferred locations in the holographic bulk, and thus circumvent key arguments made against the MERA as a model for AdS/CFT...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29044607/compassion-focused-therapy-exploring-the-effectiveness-with-a-transdiagnostic-group-and-potential-processes-of-change
#11
Jennifer Cuppage, Katie Baird, Jennifer Gibson, Richard Booth, David Hevey
OBJECTIVES: This study aimed to examine the effectiveness of a compassion focused therapy (CFT) group with a transdiagnostic population, as compared to treatment as usual (TAU). A secondary aim was to explore the potential processes of change within the treatment. DESIGN: A non-randomized control trial was used. METHOD: Fifty-eight participants who engaged in group CFT were compared to 29 participants receiving TAU. Group CFT consisted of 14 sessions twice weekly for 5 weeks and once weekly for 4 weeks...
October 17, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29027937/abrin-toxicity-and-bioavailability-after-temperature-and-ph-treatment
#12
Christina C Tam, Thomas D Henderson, Larry H Stanker, Xiaohua He, Luisa W Cheng
Abrin, one of most potent toxins known to man, is derived from the rosary pea (jequirity pea), Abrus precatorius and is a potential bioterror weapon. The temperature and pH stability of abrin was evaluated with an in vitro cell free translation (CFT) assay, a Vero cell culture cytotoxicity assay, and an in vivo mouse bioassay. pH treatment of abrin had no detrimental effect on its stability and toxicity as seen either in vitro or in vivo. Abrin exposure to increasing temperatures did not completely abrogate protein translation...
October 13, 2017: Toxins
https://www.readbyqxmd.com/read/28992923/movement-patterns-of-nilgai-antelope-in-south-texas-implications-for-cattle-fever-tick-management
#13
Aaron M Foley, John A Goolsby, Alfonso Ortega-S, J Alfonso Ortega-S, A Pérez de León, Nirbhay K Singh, Andy Schwartz, Dee Ellis, David G Hewitt, Tyler A Campbell
Wildlife, both native and introduced, can harbor and spread diseases of importance to the livestock industry. Describing movement patterns of such wildlife is essential to formulate effective disease management strategies. Nilgai antelope (Boselaphus tragocamelus) are a free-ranging, introduced ungulate in southern Texas known to carry cattle fever ticks (CFT, Rhipicephalus (Boophilus) microplus, R. (B.) annulatus). CFT are the vector for the etiological agent of bovine babesiosis, a lethal disease causing high mortality in susceptible Bos taurus populations and severely affecting the beef cattle industry...
October 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28980485/sympathetic-vascular-response-to-facial-cooling-is-increased-in-flail-phenotypes-of-amyotrophic-lateral-sclerosis
#14
Marcin Tutaj, MaŁgorzata Miller, Barbara Tomik, Aleksandra Golenia, Agnieszka Stanuszek, Katarzyna BŁońska, Agnieszka SŁowik
OBJECTIVE: To assess cardiovascular responses to cold face test (CFT) in patients with classic-onset ALS (bulbar or limb onset, ALS-C) and in patients with flail arm and flail leg phenotypes (FA/FL). METHODS: In 18 ALS-C, eight FA/FL patients and 10 age-matched controls we continuously monitored heart rate (HR), systolic (SBP), diastolic (DBP) and mean blood pressure (MBP) during two-minute baseline and one-minute cold stimulus application. HR and BP responses to CFT were calculated as differences between the peak responses and baseline values (dHR, dSBP, dDBP, dMBP), as percent changes from baseline (dHR%, dSBP%, dDBP%, dMBP%), and also latencies and durations of HR and BP responses were assessed (LatHR, tHR, LatBP, tBP)...
October 5, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28958048/evaluating-calculated-free-testosterone-as-a-predictor-of-morbidity-and-mortality-independent-of-testosterone-for-cross-sectional-and-5-year-longitudinal-health-outcomes-in-older-men-the-concord-health-and-ageing-in-men-project
#15
Benjumin Hsu, Robert G Cumming, Fiona M Blyth, Vasi Naganathan, Louise M Waite, David G Le Couteur, Markus J Seibel, David J Handelsman
To determine whether calculated free testosterone (cFT) provides prognostic information independent of serum T for predicting morbidity and mortality in older men in cross-sectional and 5-year longitudinal analyses. We studied men aged ≥70 years at baseline (n=1705), 2-year and 5-year measuring serum T (liquid chromatography-mass spectrometry), SHBG (immunoassay), cFT (an assumption-free empirical formula) together with 24 morbidity and 4 mortality outcomes. For cross-sectional and longitudinal analyses we employed a joint prediction model using generalized estimating equation models adjusted for age, smoking, comorbidities and BMI with men having both normal T and normal cFT as referent group...
September 15, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28949666/anti-de-sitter-space-from-optimization-of-path-integrals-in-conformal-field-theories
#16
Pawel Caputa, Nilay Kundu, Masamichi Miyaji, Tadashi Takayanagi, Kento Watanabe
We introduce a new optimization procedure for Euclidean path integrals, which compute wave functionals in conformal field theories (CFTs). We optimize the background metric in the space on which the path integration is performed. Equivalently, this is interpreted as a position-dependent UV cutoff. For two-dimensional CFT vacua, we find the optimized metric is given by that of a hyperbolic space, and we interpret this as a continuous limit of the conjectured relation between tensor networks and Anti-de Sitter (AdS)/conformal field theory (CFT) correspondence...
August 18, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28926210/clinical-relevance-of-retinal-structure-in-children-with-laser-treated-retinopathy-of-prematurity-versus-controls-using-optical-coherence-tomography
#17
Florina Stoica, Adela Chirita-Emandi, Nicoleta Andreescu, Alina Stanciu, Cristian G Zimbru, Maria Puiu
PURPOSE: We aimed to assess the macular anatomy using spectral domain optical coherence tomography (SD-OCT), in children born preterm who had laser-treated retinopathy of prematurity (ROP), and to investigate the relationship between structural changes in macula and visual function. METHODS: Thirty-seven 3-8 years old children were included in the study in two groups: 20 children born preterm [(<34 weeks of gestation, birthweight (BW) <2000 g)] who had laser-treated ROP in the Neonatology Department, Municipal Clinical Emergency Hospital of Timisoara, Romania; and 17 controls (children born at term, without eye disease, matched for age and gender)...
September 19, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28914874/-craniofacial-tumors-blood-supply
#18
Yu G Yakovlenko, V A Cherekaev, V N Kornienko, I N Pronin, L V Shishkina, A S Tonoyan, E I Shul'tz, A M Parshunina
Because of the spread to different anatomical regions, craniofacial tumors (CFTs) usually receive blood supply from several arterial systems, and CFT removal is often accompanied by abundant blood loss. PURPOSE: The study purpose was to develop an algorithm of diagnostic angiography for planning surgical treatment of CFT patients. MATERIAL AND METHODS: Complex preoperative angiography was performed in 72 patients with craniofacial tumors, aged 10 to 78 years (mean age, 45...
2017: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/28902331/quantitative-and-qualitative-features-of-spectral-domain-optical-coherence-tomography-provide-prognostic-indicators-for-visual-acuity-in-patients-with-choroideremia
#19
Alessandro Abbouda, Wei Sing Lim, Lina Sprogyte, Andrew R Webster, Mariya Moosajee
BACKGROUND AND OBJECTIVE: To identify qualitative and quantitative features of spectral-domain optical coherence tomography (SD-OCT) as prognostic indicators of visual acuity (VA) loss in patients with choroideremia (CHM). PATIENTS AND METHODS: Retrospective study of 57 male patients with CHM. Central foveal thickness (CFT), subfoveal choroidal thickness (SCT), fundus autofluorescence area, and evidence of outer retinal and choroidal degeneration were analyzed by SD-OCT...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28899656/greater-ankle-strength-anaerobic-and-aerobic-capacity-and-agility-predict-ground-combat-military-occupational-school-graduation-in-female-marines
#20
Katelyn Fleishman Allison, Karen A Keenan, Meleesa F Wohleber, Katherine A Perlsweig, Erin R Pletcher, Mita Lovalekar, Kim Beals, Lawrence C Coleman, Bradley C Nindl
Women can serve in all military occupational specialties (MOS); however, musculoskeletal and physiological characteristics that predict successful completion of ground combat MOS schools by female Marines are unknown. OBJECTIVES: To determine which demographic, musculoskeletal, and physiological characteristics predict graduation from infantry and vehicle ground combat MOS schools in female Marines. DESIGN: Prospective cohort study. METHODS: Prior to MOS school, the following were assessed in 62 female Marines (22...
August 24, 2017: Journal of Science and Medicine in Sport
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