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https://www.readbyqxmd.com/read/28092924/evaluation-of-the-use-of-rotational-thromboelastometry-in-the-assessment-of-fxi-deficency
#1
G N Pike, A M Cumming, J Thachil, C R M Hay, P H B Bolton-Maggs, J Burthem
INTRODUCTION: The absence of a reliable clinical test to predict bleeding tendency leaves factor XI (FXI)-deficient individuals at risk of overtreatment or under treatment. AIM: To assess whether rotational thromboelastometry has value in detection of FXI deficiency and identification of bleeding tendency. METHODS: Thromboelastometry was measured in whole blood and platelet-rich plasma (PRP) samples containing corn trypsin inhibitor (CTI) from controls (n = 50) and FXI-deficient individuals (n = 93) at tissue factor (TF) 0...
January 16, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28077315/inhibition-of-inos-alleviates-cognitive-deficits-and-depression-in-diabetic-mice-through-downregulating-the-no-sgc-cgmp-pkg-signal-pathway
#2
Xiao Yan Zhou, Fang Zhang, Chang Jiang Ying, Jing Chen, Ling Chen, Jing Dong, Yue Shi, Mang Tang, Xiao Tong Hu, Zhi Hua Pan, Na Na Xu, Kui Yang Zheng, Ren Xian Tang, Yuan Jian Song
Diabetes mellitus often results in a number of complications involving impaired brain function, including cognitive deficits and depression. However, the potential mechanisms for diabetes-related cognitive deficits and depression are not fully understood. Neurons in the hippocampal, cortical and amygdala functional regions are more susceptible to damage during hyperglycemia. Neuroprotection in the brain can rescue cognitive deficits and depression induced by hyperglycemia. This study investigated the potential mechanisms underlying diabetes-related congnitive deficits and depression, determined whether the inflammatory factor inducible nitric oxide synthase (iNOS) and the nitric oxide (NO)/soluble guanylyl cyclases (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) pathway, play key roles in cognitive deficits and depression associated...
January 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28033234/associations-between-macular-edema-and-circulatory-status-in-eyes-with-retinal-vein-occlusion-an-adaptive-optics-scanning-laser-ophthalmoscopy-study
#3
Yuto Iida, Yuki Muraoka, Akihito Uji, Sotaro Ooto, Tomoaki Murakami, Kiyoshi Suzuma, Akitaka Tsujikawa, Shigeta Arichika, Ayako Takahashi, Yuko Miwa, Nagahisa Yoshimura
PURPOSE: To investigate associations between parafoveal microcirculatory status and foveal pathomorphology in eyes with macular edema (ME) secondary to retinal vein occlusion (RVO). METHODS: Ten consecutive patients (10 eyes) with acute retinal vein occlusion were enrolled, 9 eyes of which received intravitreal ranibizumab (IVR) injections. Foveal morphologic changes were examined via optical coherence tomography (OCT), and parafoveal circulatory status was assessed via adaptive optics scanning laser ophthalmoscopy (AO-SLO)...
December 28, 2016: Retina
https://www.readbyqxmd.com/read/28031700/long-term-results-of-combination-therapy-using-anti-vegf-agents-and-dexamethasone-intravitreal-implant-for-retinal-vein-occlusion-an-investigational-case-series
#4
Michael A Singer, Michael E Jansen, Lyndon Tyler, Paul Woods, Faisal Ansari, Udit Jain, Joshua Singer, Darren Bell, Chelsey Krambeer
BACKGROUND: One limitation of anti-VEGF therapy is the need for monthly retreatment to maintain efficacy. The purpose of this study was to determine the duration of effect in eyes with macular edema (ME) secondary to branch or central retinal vein occlusion (BRVO or CRVO) treated with anti-VEGF therapy plus sustained-release dexamethasone (DEX implant; Ozurdex). MATERIALS AND METHODS: This open-label, interventional case series included 62 eyes with ME due to RVO, central foveal thickness (CFT) >300 μm, and best-corrected visual acuity (BCVA) of 20/40 or worse...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28003780/aflibercept-in-refractory-wet-amd-treated-with-ranibizumab-anatomical-and-visual-outcome
#5
Sleiman Abou-Ltaif
PURPOSE: To assess the anatomical outcome of patients with exudative age-related macular degeneration resistant to ranibizumab treated with aflibercept. METHOD: Prospective, interventional, case series, where we treated a group of patients deemed resistant to Ranibizumab after 6 months of persistence of intra- or subretinal fluid despite continuous treatment. RESULTS: The study included 17 patients, 3 males and 14 females. The average males age was 85 (range 83-87), and that of females was 79...
October 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/27999117/performance-of-mass-spectrometry-steroid-profiling-for-diagnosis-of-polycystic-ovary-syndrome
#6
D J Handelsman, H J Teede, R Desai, R J Norman, L J Moran
STUDY QUESTION: How well does multi-analyte steroid mass spectrometry (MS) profiling classify women with and without polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Our liquid chromatography MS (LC-MS) steroid profiling only minimally improves discrimination of women with and without PCOS compared with a direct testosterone immunoassay (T_IA) and the free androgen index (FAI). WHAT IS KNOWN ALREADY: Blood testosterone measured by direct (non-extraction) immunoassay overlaps between women with and without PCOS...
December 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27993719/minimally-invasive-percutaneous-plates-versus-conventional-fixation-techniques-for-distal-tibial-fractures-a-meta-analysis
#7
REVIEW
Ang Li, Zhijian Wei, Han Ding, Haoshuai Tang, Yang Liu, Jiaxiao Shi, Hengxing Zhou, Shi-Qing Feng
OBJECTIVE: This meta-analysis was performed to determine the effects of minimally invasive percutaneous plate osteosynthesis (MIPO) versus conventional fixation techniques (CFT) for treating distal tibial fractures. METHODS: A literature search was performed in EMBASE, Medline, the Cochrane Library, and Web of Science. The trials searched were evaluated for eligibility. The Cochrane Collaboration's Review Manager software was used to perform meta-analyses. RESULTS: Eight studies were enrolled, including five randomized controlled trials, one control-matched trial and two retrospective cohort trials...
December 16, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27982657/chaos-in-chiral-condensates-in-gauge-theories
#8
Koji Hashimoto, Keiju Murata, Kentaroh Yoshida
Assigning a chaos index for dynamics of generic quantum field theories is a challenging problem because the notion of a Lyapunov exponent, which is useful for singling out chaotic behavior, works only in classical systems. We address the issue by using the AdS/CFT correspondence, as the large N_{c} limit provides a classicalization (other than the standard ℏ→0) while keeping nontrivial quantum condensation. We demonstrate the chaos in the dynamics of quantum gauge theories: The time evolution of homogeneous quark condensates ⟨q[over ¯]q⟩ and ⟨q[over ¯]γ_{5}q⟩ in an N=2 supersymmetric QCD with the SU(N_{c}) gauge group at large N_{c} and at a large 't Hooft coupling λ≡N_{c}g_{YM}^{2} exhibits a positive Lyapunov exponent...
December 2, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27982211/is-there-a-relationship-between-outer-retinal-destruction-and-choroidal-changes-in-cone-dystrophy
#9
Onder Ayyildiz, Gokhan Ozge, Murat Kucukevcilioglu, Cem Ozgonul, Tarkan Mumcuoglu, Ali Hakan Durukan, Fatih Mehmet Mutlu
Purpose: The aim of the present study was to use enhanced depth imaging optical coherence tomography (EDI-OCT) to investigate choroidal changes in patients with cone dystrophy (CD) and to correlate these findings with clinical and electroretinography (ERG) findings. Methods: This case-control study included 40 eyes of 20 patients with CD and 40 eyes of 40 age- and refraction-matched healthy individuals. Choroidal thickness (CT) measurements were obtained under the foveal center and at 500 and 1,500 μm from the nasal and temporal regions to the center of the fovea, respectively...
September 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/27973691/effects-of-diet-and-insulin-on-dopamine-transporter-activity-and-expression-in-rat-caudate-putamen-nucleus-accumbens-and-midbrain
#10
Kymry T Jones, Catherine Woods, Juan Zhen, Tamara Antonio, Kenneth Carr, Maarten E A Reith
Food restriction (FR) and obesogenic (OB) diets are known to alter brain dopamine transmission and exert opposite modulatory effects on behavioral responsiveness to psychostimulant drugs of abuse. Mechanisms underlying these diet effects are not fully understood. In the present study we examined diet effects on expression and function of the dopamine transporter (DAT) in caudate-putamen (CPu), nucleus accumbens (NAc), and midbrain regions. DA uptake by CPu, NAc or midbrain synapto(neuro)somes was measured in vitro with rotating disk electrode voltammetry or with [(3) H]DA uptake and was found to correlate with DA transporter (DAT) surface expression, assessed by maximal [(3) H]CFT binding and surface biotinylation assays...
December 14, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27955740/control-of-animal-brucellosis-the-malaysian-experience
#11
REVIEW
M Zamri-Saad, M I Kamarudin
Brucellosis is a zoonotic disease characterized by reproductive failure in animals and undulent fever in humans. In cattle, it is caused by Brucella abortus while in goats by Brucella melitensis, the main cause of brucellosis in humans. Brucellosis in livestock has been associated with importation of animals from breeder herd of unknown disease status. The prevalence of bovine brucellosis Brucella abortus in 2014 ranged between 1% and 2% in Thailand and Indonesia, and 4%-5% in Malaysia and Myanmar. Prevalence of goat brucellosis Brucella melitensis is approximately 1% in Malaysia and Thailand...
December 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27926787/comparison-of-the-effects-of-a-balanced-crystalloid-based-and-a-saline-based-tetrastarch-solution-on-canine-whole-blood-coagulation-and-platelet-function
#12
Annina Reuteler, Shannon Axiak-Flammer, Judith Howard, Katja-Nicole Adamik
OBJECTIVE: To evaluate the effects of a 6% hydroxyethyl starch (130/0.42) solution in either a buffered, electrolyte-balanced (HES-BAL), or a saline (HES-SAL) carrier solution on canine platelet function and whole blood coagulation. DESIGN: Prospective, randomized study. SETTING: University teaching hospital. ANIMALS: Thirty-seven client-owned dogs undergoing general anesthesia for arthroscopy or imaging studies. INTERVENTIONS: Dogs received a 15 mL/kg intravenous bolus of HES-SAL (n = 13), HES-BAL (n = 14), or a modified Ringer's solution (n = 10) over 30-40 minutes...
December 7, 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27893588/suite-pet-ct-neuroimaging-for-the-diagnosis-of-parkinson-s-disease-statistical-parametric-mapping-analysis
#13
Ruimin Wang, Baixuan Xu, Zhe Guo, Tong Chen, Jinming Zhang, Yingmao Chen, Haiyan Zhu
OBJECTIVES: The aim of this study was to investigate the topographical distribution of dopamine transporter (DAT), dopamine D2 receptor, and glucose metabolism in Parkinson's disease (PD) using PET/computed tomography (CT) scanning and statistical parametric mapping (SPM) analysis. PARTICIPANTS AND METHODS: Seventy-four patients (58 PD patients and 16 normal controls) underwent DAT, D2 receptor, and glucose brain PET/CT scans using C-methyl-N-2-β-carbomethoxy-3-β-(4-fluorophenyl) tropane (C-β-CFT), C-raclopride (C-RAC), and fluorine-18-fluorodeoxyglucose (F-FDG) radiotracers for the respective scans...
November 28, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27889502/role-of-lamellar-hole-associated-epiretinal-proliferation-in-lamellar-macular-holes
#14
Roberto dell'Omo, Gianni Virgili, Stanislao Rizzo, Serena De Turris, Giovanni Coclite, Dario Giorgio, Ermanno dell'Omo, Ciro Costagliola
PURPOSE: To compare the morphologic and functional characteristics and response to surgery of lamellar macular holes (LMHs) with and without lamellar hole-associated epiretinal proliferation (LHEP) and standard epiretinal membrane (ERM). DESIGN: Retrospective observational case series. METHODS: Setting: Vitreoretinal clinical practice. STUDY POPULATION: Eigthy-four eyes of 84 patients. The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence tomography (SD-OCT) and an area of increased autofluorescence on blue- fundus autofluorescence (B-FAF)...
November 23, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27886509/smooth-horizonless-geometries-deep-inside-the-black-hole-regime
#15
Iosif Bena, Stefano Giusto, Emil J Martinec, Rodolfo Russo, Masaki Shigemori, David Turton, Nicholas P Warner
We construct the first family of horizonless supergravity solutions that have the same mass, charges, and angular momenta as general supersymmetric rotating D1-D5-P black holes in five dimensions. This family includes solutions with arbitrarily small angular momenta, deep within the regime of quantum numbers and couplings for which a large classical black hole exists. These geometries are well approximated by the black-hole solution, and in particular exhibit the same near-horizon throat. Deep in this throat, the black-hole singularity is resolved into a smooth cap...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27886495/new-integrable-4d-quantum-field-theories-from-strongly-deformed-planar-n-4-supersymmetric-yang-mills-theory
#16
Ömer Gürdoğan, Vladimir Kazakov
We introduce a family of new integrable quantum field theories in four dimensions by considering the γ-deformed N=4 supersymmetric Yang-Mills (SYM) theory in the double scaling limit of large imaginary twists and small coupling. This limit discards the gauge fields and retains only certain Yukawa and scalar interactions with three arbitrary effective couplings. In the 't Hooft limit, these 4D theories are integrable, and contain a wealth of conformal correlators such that the whole arsenal of AdS/CFT integrability remains applicable...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27867047/assessing-the-intra-species-genetic-variability-in-the-clonal-pathogen-campylobacter-fetus-crisprs-are-highly-polymorphic-dna-markers
#17
Lucía Calleros, Laura Betancor, Gregorio Iraola, Alejandra Méndez, Claudia Morsella, Fernando Paolicchi, Silvia Silveyra, Alejandra Velilla, Ruben Pérez
Campylobacter fetus is a Gram-negative, microaerophilic bacterium that infects animals and humans. The subspecies Campylobacter fetus subsp. fetus (Cff) affects a broad range of vertebrate hosts and induces abortion in cows and sheep. Campylobacter fetus subsp. venerealis (Cfv) is restricted to cattle and causes the endemic disease bovine genital campylobacteriosis, which triggers reproductive problems and is responsible for major economic losses. Campylobacter fetus subsp. testudinum (Cft) has been isolated mostly from apparently healthy reptiles belonging to different species but also from ill snakes and humans...
January 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27848983/treatment-of-polypoidal-choroidal-vasculopathy-by-photodynamic-therapy-aflibercept-and-dexamethasone-triple-therapy
#18
Mary Ho, Donald C F Woo, Vesta C K Chan, Alvin L Young, Marten E Brelen
Polypoidal choroidal vasculopathy is a relatively common type of degenerative macular disease among the Chinese population. This study aims to describe the therapeutic responses to combination therapy with photodynamic therapy, intravitreal aflibercept and intravitreal dexamethasone in patients with polypoidal choroidal vasculopathy. A prospective series of 17 eyes of 13 patients suffering from treatment-naïve polypoidal choroidal vasculoapathy were recruited. All cases received triple therapy with photodynamic therapy, intravitreal aflibercept and intravitreal dexamethasone and one year outcomes were reported...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27812235/resistance-of-bt-maize-mon810-against-the-stem-borers-busseola-fusca-fuller-and-chilo-partellus-swinhoe-and-its-yield-performance-in-kenya
#19
Tadele Tefera, Stephen Mugo, Murenga Mwimali, Bruce Anani, Regina Tende, Yoseph Beyene, Simon Gichuki, Sylvester O Oikeh, Francis Nang'ayo, James Okeno, Evans Njeru, Kiru Pillay, Barbara Meisel, B M Prasanna
A study was conducted to assess the performance of maize hybrids with Bt event MON810 (Bt-hybrids) against the maize stem borer Busseola fusca (Fuller) in a biosafety greenhouse (BGH) and against the spotted stem borer Chilo partellus (Swinhoe) under confined field trials (CFT) in Kenya for three seasons during 2013-2014. The study comprised 14 non-commercialized hybrids (seven pairs of near-isogenic Bt and non-Bt hybrids) and four non-Bt commercial hybrids. Each plant was artificially infested twice with 10 first instar larvae...
November 2016: Crop Protection
https://www.readbyqxmd.com/read/27792776/brucellosis-seropositivity-in-animals-and-humans-in-ethiopia-a-meta-analysis
#20
Getachew Tadesse
BACKGROUND: The objectives of this study were to assess the heterogeneities of estimates and to estimate the seroprevalence of brucellosis in animals and humans in Ethiopia. METHODS/PRINCIPAL FINDINGS: Data from 70 studies covering 75879 animals and 2223 humans were extracted. Rose Bengal Plate Test (RBPT) and Complement Fixation Test (CFT) in series were the most frequently used serological tests. A random effects model was used to calculate pooled prevalence estimates...
October 2016: PLoS Neglected Tropical Diseases
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