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https://www.readbyqxmd.com/read/28441487/the-isomeric-preference-of-an-atypical-dopamine-transporter-inhibitor-contributes-to-its-selection-of-the-transporter-conformation
#1
Ara M Abramyan, Sebastian Stolzenberg, Zheng Li, Claus J Loland, Frank Noé, Lei Shi
Cocaine, a widely abused psychostimulant, inhibits the dopamine transporter (DAT) by trapping the protein in an outward-open conformation, whereas atypical DAT inhibitors such as benztropine have low abuse liability and prefer less outward-open conformations. Here, we use a spectrum of computational modeling and simulation approaches to obtain the underlying molecular mechanism in atomistic detail. Interestingly, our quantum mechanical calculations and molecular dynamics (MD) simulations suggest that a benztropine derivative JHW007 prefers a different stereoisomeric conformation of tropane in binding to DAT compared to that of a cocaine derivative, CFT...
April 25, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28439440/a-comparison-of-the-effects-of-20-mannitol-and-3-nacl-on-coagulation-parameters-in-vitro-using-rotem-a-prospective-randomized-crossover-study
#2
Achmet Ali, Bilge Şencan, Pulat Akın Sabancı, Demet Altun, Aylin Tetik, Lerzan Recep Doğan, İbrahim Özkan Akıncı
OBJECTIVE: The aim of the present study is to compare the effect of 20% mannitol and 3% NaCl on blood coagulation in vitro using rotational thromboelastometry (ROTEM). METHODS: Twenty-millilitre blood samples were obtained from 15 volunteers. In each group, 2 mL blood samples were collected into both polypropylene tubes and EDTA tubes for ROTEM and hemogram analysis. After sampling, blood samples were diluted with test solutions. Group C (control): Only blood, Group M (mannitol): 7% vol 20% mannitol concentration in the blood, Group hypertonic saline (HS): 7% vol 3% hypertonic saline (NaCl) in the blood, Group M/H (mannitol and hydroxyethyl starch solutions [HES]): 6% vol 20% mannitol concentration and 8% vol HES in the blood and Group HS/H (hypertonic saline and HES): 6% vol 3% hypertonic saline concentration and 8% vol HES in the blood...
April 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/28436640/intravitreal-aflibercept-for-patients-with-diabetic-macular-edema-refractory-to-bevacizumab-or-ranibizumab-analysis-of-response-to-aflibercept
#3
Yen-Yi Chen, Pei-Yao Chang, Jia-Kang Wang
PURPOSE: To investigate the short-term efficacy and safety of intravitreal aflibercept in a case series of patients with diabetic macular edema (DME) refractory to ranibizumab or bevacizumab. DESIGN: A retrospective chart review. METHODS: From September 2013 to March 2016, we identified patients with DME who developed resistance to bevacizumab or ranibizumab. Three monthly intravitreal aflibercept injections were administered in refractory cases...
April 10, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28431870/the-effect-of-hypertonic-saline-and-mannitol-on-coagulation-in-moderate-traumatic-brain-injury-patients
#4
Haifeng Wang, Hongshi Cao, Xiaohong Zhang, Liang Ge, Li Bie
BACKGROUND: Hyperosmolar therapy, using either hypertonic saline (HTS) or mannitol (MT), is considered the treatment of choice for intracranial hypertension, a disorder characterized by high intracranial pressure (ICP). However, hyperosmolar agents have been postulated to impair coagulation and platelet function. The aim of this study was to identify whether HTS and MT could affect coagulation in moderate traumatic brain injury (TBI) patients. METHODS: In this prospective and randomized double-blind study, we included adult patients with moderate TBI...
April 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28416492/intravitreal-triamcinolone-acetate-for-radiation-maculopathy-recalcitrant-to-high-dose-intravitreal-bevacizumab
#5
Richard I Kaplan, Sonal S Chaugule, Paul T Finger
BACKGROUND/AIMS: To evaluate the effect of adjuvant intravitreal triamcinolone acetonide (ITA) for radiation maculopathy (RM) recalcitrant to high-dose bevacizumab in patients with choroidal melanoma after plaque radiotherapy. METHODS: Eight eyes of eight patients with RM secondary to plaque radiotherapy for choroidal melanoma, recalcitrant to high-dose bevacizumab (3.0 mg) were retrospectively evaluated. Intravitreal injections of ITA (4 mg/0.1 mL) were performed at 4-week to 16-week intervals as an adjunct to continued bevacizumab therapy...
April 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28407307/adenosine-a1-receptors-measured-with-11-c-mpdx-pet-in-early-parkinson-s-disease
#6
Masahiro Mishina, Kenji Ishii, Yuichi Kimura, Masahiko Suzuki, Shin Kitamura, Kenji Ishibashi, Muneyuki Sakata, Keiichi Oda, Shiro Kobayashi, Kazumi Kimura, Kiichi Ishiwata
Adenosine A1 receptors (A1 Rs) interact negatively with dopamine D1 receptors (D1 Rs) in neurons of the basal ganglia's direct pathway, while adenosine A2A receptors (A2A Rs) negatively interact with dopamine D2 receptors (D2 Rs) in indirect-pathway neurons. The aim of this study was to investigate the cerebral density of A1 Rs in Parkinson's disease (PD) in its early stages, using PET scans with the radioligand 8-dicyclopropylmethyl-1-(11) C-methyl-3-propylxanthine ((11) C-MPDX). We studied 10 drug-naïve patients with early PD...
April 13, 2017: Synapse
https://www.readbyqxmd.com/read/28405744/long-term-follow-up-of-fellow-eye-in-patients-with-lamellar-macular-hole
#7
Ugo Nava, Matteo Giuseppe Cereda, Ferdinando Bottoni, Chiara Preziosa, Marco Pellegrini, Andrea Giani, Giovanni Staurenghi
BACKGROUND: To evaluate macular changes in fellow eyes of patients diagnosed with lamellar macular hole (LMH) using spectral-domain optical coherence tomography (SD-OCT) and blue fundus autofluorescence (B-FAF). METHODS: Fellow eyes of patients diagnosed with a LMH were retrospectively evaluated on OCT. Best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were recorded. Corresponding B-FAF images, vitreo-macular relations, and type of epiretinal membranes (ERMs) were also examined...
April 13, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28393783/coagulopathies-in-cyanotic-cardiac-patients-an-analysis-with-three-point-of-care-testing-devices-thromboelastography-rotational-thromboelastometry-and-sonoclot-analyzer
#8
Vandana Bhardwaj, Poonam Malhotra, Suruchi Hasija, Ujjwal Kumar Chowdury, Neha Pangasa
INTRODUCTION: In the last few years, viscoelastic point-of-care (POC) coagulation devices such as thromboelastography (TEG), rotational thromboelastometry (ROTEM), and Sonoclot (SON) analyzer have been increasingly used in major surgeries for timely assessment and management of coagulopathies. The aim of the present study was to evaluate coagulation profile of cyanotic cardiac patients with TEG, ROTEM, and SON analyzer. In addition, we assessed the correlation of standard laboratory coagulation tests and postoperative chest drain output (CDO) with the parameters of POC testing devices...
April 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28393035/retinal-ganglion-cell-complex-changes-using-spectral-domain-optical-coherence-tomography-in-diabetic-patients-without-retinopathy
#9
Ahmed I Hegazy, Rasha H Zedan, Tamer A Macky, Soheir M Esmat
AIM: To assess the ganglion cell complex (GCC) thickness in diabetic eyes without retinopathy. METHODS: Two groups included 45 diabetic eyes without retinopathy and 21 non diabetic eyes. All subjects underwent full medical and ophthalmological history, full ophthalmological examination, measuring GCC thickness and central foveal thickness (CFT) using the RTVue(®) spectral domain-optical coherence tomography (SD-OCT), and HbA1C level. RESULTS: GCC focal loss volume (FLV%) was significantly more in diabetic eyes (22...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379652/quantitative-reduction-in-central-foveal-thickness-after-first-anti-vegf-injection-as-a-predictor-of-final-outcome-in-brvo-patients
#10
Rupak Roy, Kumar Saurabh, Avirupa Ghose, Dhileesh P Chandrasekharan, Preeti Sharma, Swakshyar Saumya Pal, Sudipta Das
PURPOSE: To analyze the predictive ability of quantitative reduction in central foveal thickness (CFT) after the first antivascular endothelial growth factor (anti-VEGF) injection to assess final outcome in branch retinal vein occlusion (BRVO) patients. DESIGN: A retrospective interventional consecutive case series. METHODS: We retrospectively reviewed 60 treatment-naive BRVO patients. All the patients were treated with bevacizumab injection pro re nata...
March 29, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28379270/hexacyanometallates-for-sodium-ion-batteries-insights-into-higher-redox-potentials-using-d-electronic-spin-configurations
#11
Duho Kim, Taesoon Hwang, Jin-Myoung Lim, Min-Sik Park, Maenghyo Cho, Kyeongjae Cho
A fundamental understanding of anomalous redox mechanisms in hexacyanometallate compounds, compared with conventional NaMO2 systems (M: transition metals), is presented based on first-principles calculations and experimental validations. From theoretical calculations, we identified low-spin and high-spin states of Fe ions coordinated by the cyanide group (-CN) with the same oxidation state (Fe(2+)) in Na2Fe2(CN)6. Considering the site dependency of d electronic spin configurations based on the crystal field theory (CFT) of transition metals (TMs), we calculated the thermodynamic mixing energy using Na2Fe2(CN)6 and Na2Mn2(CN)6 for obtaining a thermodynamically stable phase of Na2FeMn(CN)6...
April 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28368973/effect-of-smoking-on-macular-function-and-structure-in-active-smokers-versus-passive-smokers
#12
Amany Abd El-Fattah El-Shazly, Yousra Ahmed Thabet Farweez, Yasser Abdelmageuid Elzankalony, Lamia Salah Elewa, Botheina Ahmed Thabet Farweez
PURPOSE: The aim is to study the effects of cigarette smoking on the structural and functional alterations of the macula in eyes of healthy young smokers. METHODS: Cross-sectional clinical study included 100 active smokers (Group 1) and 100 age- and sex-matched healthy passive smokers (Group 2). All participants underwent a complete ophthalmologic assessment, axial length measurement, central corneal thickness measurement, spectral domain optical coherence tomography, and multifocal electroretinogram...
March 30, 2017: Retina
https://www.readbyqxmd.com/read/28367162/factors-affecting-the-visual-outcome-in-acute-central-serous-chorioretinopathy
#13
Qamar Ul Islam, Muhammad Asad Farooq, Mohammad Asim Mehboob
OBJECTIVE: To determine the visual outcome in patients with acute Central serous chorioretinopathy (CSCR) and to analyze the association of clinical, angiographic and tomographic factors with final visual outcome in Pakistani population. METHODS: This study was conducted at AFIO Rawalpindi and PNS Shifa Naval hospital Karachi from November 2011 to August 2016. Fifty five eyes of 53 patients with acute CSCR were included. All patients underwent a detailed ophthalmic examination including SD OCT imaging at baseline, One month and three month and FFA was performed at baseline...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28367036/natural-short-term-course-of-recurrent-macular-edema-following-intravitreal-bevacizumab-therapy-in-branch-retinal-vein-occlusion
#14
Su Jin Yoo, Jae Hui Kim, Tae Gon Lee, Jong Woo Kim, Sung Won Cho, Jung Il Han
PURPOSE: To evaluate the 3-month natural course of recurrent macular edema secondary to branch retinal vein occlusion (BRVO) treated with intravitreal bevacizumab. METHODS: This retrospective, observational study included 36 eyes with macular edema secondary to BRVO. All patients were initially treated with intravitreal bevacizumab for macular edema. Recurrence of macular edema was either not treated (untreated group) or treated with a single intravitreal bevacizumab injection (treated group)...
April 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28366074/intravitreal-bevacizumab-and-dexamethasone-implant-for-treatment-of-chronic-diabetic-macular-edema
#15
Emre Güler, Yüksel Totan, Fatma Betül Güragaç
OBJECTIVE: To evaluate anatomical and functional outcomes of intraviteal bevacizumab (IVB) in patients with chronic diabetic macular edema (DME), and the effectivity and safety of dexamethasone implant in those unresponsive to regular IVB treatment. METHODS: Thirty-five eyes of 35 patients (16 male and 19 female) with chronic DME (central foveal thickness (CFT)  > 275 μm, duration  > 6 months) received three injections of 2.5 mg IVB with six-week intervals...
June 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28341048/genetic-analysis-of-coagulation-properties-curd-firming-modeling-milk-yield-composition-and-acidity-in-sarda-dairy-sheep
#16
G Bittante, C Cipolat-Gotet, M Pazzola, M L Dettori, G M Vacca, A Cecchinato
Sheep milk is an important source of food, especially in Mediterranean countries, and is used in large part for cheese production. Milk technological traits are important for the sheep dairy industry, but research is lacking into the genetic variation of such traits. Therefore the aim of this study was to estimate the heritability of traditional milk coagulation properties and curd firmness modeled on time t (CFt) parameters, and their genetic relationships with test-day milk yield, composition (fat, protein, and casein content), and acidity in Sarda dairy sheep...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28338558/correlation-between-central-foveal-thickness-and-visual-acuity-in-patients-with-idiopathic-vitreomacular-traction
#17
Mehmet M Uzel, Mehmet Citirik, Cagri Ilhan, Kemal Tekin
PURPOSE: To evaluate the impact of preoperative central foveal thickness (CFT) on visual acuity after surgery in patients with idiopathic vitreomacular traction and to calculate a cut-off value in preoperative CFT. METHODS: Thirty-five patients with idiopathic vitreomacular traction were evaluated retrospectively. A complete ophthalmological examination including spectral domain optical coherence tomography was performed preoperatively and at 12 months after the surgery...
March 23, 2017: Retina
https://www.readbyqxmd.com/read/28333881/outer-retinal-layer-thickness-as-good-visual-predictor-in-patients-with-diabetic-macular-edema
#18
Tamer F Eliwa, Mahdi A Hussein, Mohamed A Zaki, Osama A Raslan
PURPOSE: To evaluate the relationship between outer retinal layer (ORL) thickness in diabetic macular edema to visual acuity (VA). METHODS: Ninety-five eyes were included in this prospective nonrandomized case-control study. They divided into 30 cases of healthy normal subjects and 65 cases of nonproliferative diabetic retinopathy with diabetic macular edema. Complete ophthalmic examination and spectral domain-optical coherence tomography were done for all cases and analyzed to measure central foveal point thickness (CFT), ORL thickness at fovea, and subfoveal choroidal thickness...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28324879/quantitative-analysis-of-uveitis-macular-edema-in-multiple-sclerosis-patients-receiving-deep-posterior-sub-tenon-triamcinolone-acetonide-injection
#19
Svetlana Jovanović, Tatjana Šarenac Vulović, Filip Radotić, Zorica Tončić, Maja Živković, Nenad Petrović
AIM: We aimed to analyze the effects of adjunctive posterior sub-Tenon capsule triamcinolone acetonide injection in the treatment of intermediate uveitis macular edema in multiple sclerosis patients that could not be controlled by systemic corticosteroid medications and immunomodulators. METHODS: The study included 30 eyes of 25 patients with multiple sclerosis who received a posterior sub-Tenon injection of 40 mg/mL triamcinolone acetonide. Parameters monitored for therapy efficiency were best-corrected visual acuity, intraocular pressure, central foveal thickness (CFT), and fluorescein angiography (FA) scores...
March 22, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28315319/interferon-alpha2a-and-systemic-corticosteroid-in-monotherapy-in-chronic-uveitis-results-of-the-randomised-controlled-birdferon-study
#20
Christine Fardeau, Anne Simon, Benoît Rodde, Fabiana Viscogliosi, Pierre Labalette, Vincent Looten, Sophie Tézenas du Montcel, Phuc LeHoang
PURPOSE: Macular edema is the leading cause of vision loss in bilateral chronic non-infectious posterior uveitis, and is used to being treated using corticosteroids, immunosuppressive agents and biotherapies. The aim of this trial was to assess and compare the efficacy and safety of corticosteroids and IFN-α in adults with such conditions. STUDY DESIGN: Randomized controlled trial SUBJECTS: Adult patients with bilateral posterior autoimmune non-infectious and non-tumoral uveitis complicated by macular edema in at least one eye, were recruited...
March 14, 2017: American Journal of Ophthalmology
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