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https://www.readbyqxmd.com/read/27893588/suite-pet-ct-neuroimaging-for-the-diagnosis-of-parkinson-s-disease-statistical-parametric-mapping-analysis
#1
Ruimin Wang, Baixuan Xu, Zhe Guo, Tong Chen, Jinming Zhang, Yingmao Chen, Haiyan Zhu
OBJECTIVES: The aim of this study was to investigate the topographical distribution of dopamine transporter (DAT), dopamine D2 receptor, and glucose metabolism in Parkinson's disease (PD) using PET/computed tomography (CT) scanning and statistical parametric mapping (SPM) analysis. PARTICIPANTS AND METHODS: Seventy-four patients (58 PD patients and 16 normal controls) underwent DAT, D2 receptor, and glucose brain PET/CT scans using C-methyl-N-2-β-carbomethoxy-3-β-(4-fluorophenyl) tropane (C-β-CFT), C-raclopride (C-RAC), and fluorine-18-fluorodeoxyglucose (F-FDG) radiotracers for the respective scans...
November 28, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27889502/role-of-lamellar-hole-associated-epiretinal-proliferation-in-lamellar-macular-holes
#2
Roberto dell'Omo, Gianni Virgili, Stanislao Rizzo, Serena De Turris, Giovanni Coclite, Dario Giorgio, Ermanno dell'Omo, Ciro Costagliola
PURPOSE: To compare the morphologic and functional characteristics and response to surgery of lamellar macular holes (LMHs) with and without lamellar hole-associated epiretinal proliferation (LHEP) and standard epiretinal membrane (ERM). DESIGN: Retrospective observational case series. METHODS: Setting: Vitreoretinal clinical practice. STUDY POPULATION: Eigthy-four eyes of 84 patients. The included eyes must present an irregular foveal contour and schitic or cavitated lamellar separation of neurosensory retina on spectral-domain optical coherence tomography (SD-OCT) and an area of increased autofluorescence on blue- fundus autofluorescence (B-FAF)...
November 23, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27886509/smooth-horizonless-geometries-deep-inside-the-black-hole-regime
#3
Iosif Bena, Stefano Giusto, Emil J Martinec, Rodolfo Russo, Masaki Shigemori, David Turton, Nicholas P Warner
We construct the first family of horizonless supergravity solutions that have the same mass, charges, and angular momenta as general supersymmetric rotating D1-D5-P black holes in five dimensions. This family includes solutions with arbitrarily small angular momenta, deep within the regime of quantum numbers and couplings for which a large classical black hole exists. These geometries are well approximated by the black-hole solution, and in particular exhibit the same near-horizon throat. Deep in this throat, the black-hole singularity is resolved into a smooth cap...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27886495/new-integrable-4d-quantum-field-theories-from-strongly-deformed-planar-n-4-supersymmetric-yang-mills-theory
#4
Ömer Gürdoğan, Vladimir Kazakov
We introduce a family of new integrable quantum field theories in four dimensions by considering the γ-deformed N=4 supersymmetric Yang-Mills (SYM) theory in the double scaling limit of large imaginary twists and small coupling. This limit discards the gauge fields and retains only certain Yukawa and scalar interactions with three arbitrary effective couplings. In the 't Hooft limit, these 4D theories are integrable, and contain a wealth of conformal correlators such that the whole arsenal of AdS/CFT integrability remains applicable...
November 11, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27867047/assessing-the-intra-species-genetic-variability-in-the-clonal-pathogen-campylobacter-fetus-crisprs-are-highly-polymorphic-dna-markers
#5
Lucía Calleros, Laura Betancor, Gregorio Iraola, Alejandra Méndez, Claudia Morsella, Fernando Paolicchi, Silvia Silveyra, Alejandra Velilla, Ruben Pérez
Campylobacter fetus is a Gram-negative, microaerophilic bacterium that infects animals and humans. The subspecies Campylobacter fetus subsp. fetus (Cff) affects a broad range of vertebrate hosts and induces abortion in cows and sheep. Campylobacter fetus subsp. venerealis (Cfv) is restricted to cattle and causes the endemic disease bovine genital campylobacteriosis, which triggers reproductive problems and is responsible for major economic losses. Campylobacter fetus subsp. testudinum (Cft) has been isolated mostly from apparently healthy reptiles belonging to different species but also from ill snakes and humans...
November 17, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27848983/treatment-of-polypoidal-choroidal-vasculopathy-by-photodynamic-therapy-aflibercept-and-dexamethasone-triple-therapy
#6
Mary Ho, Donald C F Woo, Vesta C K Chan, Alvin L Young, Marten E Brelen
Polypoidal choroidal vasculopathy is a relatively common type of degenerative macular disease among the Chinese population. This study aims to describe the therapeutic responses to combination therapy with photodynamic therapy, intravitreal aflibercept and intravitreal dexamethasone in patients with polypoidal choroidal vasculopathy. A prospective series of 17 eyes of 13 patients suffering from treatment-naïve polypoidal choroidal vasculoapathy were recruited. All cases received triple therapy with photodynamic therapy, intravitreal aflibercept and intravitreal dexamethasone and one year outcomes were reported...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27812235/resistance-of-bt-maize-mon810-against-the-stem-borers-busseola-fusca-fuller-and-chilo-partellus-swinhoe-and-its-yield-performance-in-kenya
#7
Tadele Tefera, Stephen Mugo, Murenga Mwimali, Bruce Anani, Regina Tende, Yoseph Beyene, Simon Gichuki, Sylvester O Oikeh, Francis Nang'ayo, James Okeno, Evans Njeru, Kiru Pillay, Barbara Meisel, B M Prasanna
A study was conducted to assess the performance of maize hybrids with Bt event MON810 (Bt-hybrids) against the maize stem borer Busseola fusca (Fuller) in a biosafety greenhouse (BGH) and against the spotted stem borer Chilo partellus (Swinhoe) under confined field trials (CFT) in Kenya for three seasons during 2013-2014. The study comprised 14 non-commercialized hybrids (seven pairs of near-isogenic Bt and non-Bt hybrids) and four non-Bt commercial hybrids. Each plant was artificially infested twice with 10 first instar larvae...
November 2016: Crop Protection
https://www.readbyqxmd.com/read/27792776/brucellosis-seropositivity-in-animals-and-humans-in-ethiopia-a-meta-analysis
#8
Getachew Tadesse
BACKGROUND: The objectives of this study were to assess the heterogeneities of estimates and to estimate the seroprevalence of brucellosis in animals and humans in Ethiopia. METHODS/PRINCIPAL FINDINGS: Data from 70 studies covering 75879 animals and 2223 humans were extracted. Rose Bengal Plate Test (RBPT) and Complement Fixation Test (CFT) in series were the most frequently used serological tests. A random effects model was used to calculate pooled prevalence estimates...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27791250/retinal-neurovascular-changes-appear-earlier-in-type-2-diabetic-patients
#9
Luisa Pierro, Lorenzo Iuliano, Maria Vittoria Cicinelli, Giuseppe Casalino, Francesco Bandello
PURPOSE: To investigate the early neurodegenerative changes of inner retina and choroid in type 1 and type 2 diabetic patients without retinopathy and with early-stage retinopathy. METHODS: In this observational cross-sectional study, 90 right eyes of 90 naive type 1 and 2 diabetic patients without diabetic retinopathy (DR) and with mild to moderate nonproliferative DR (NPDR) were analyzed. Forty healthy eyes were included as controls. We used spectral-domain optical coherence tomography to evaluate the ganglion cell complex (GCC) thickness, the retinal nerve fiber layer (RNFL) thickness, the choroid thickness, and the central foveal thickness (CFT) of patients and controls...
October 22, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27769324/effect-of-aflibercept-on-refractory-macular-edema-associated-with-central-retinal-vein-occlusion
#10
Michael N Cohen, Samuel K Houston, Alexander Juhn, Allen C Ho, Carl D Regillo, James Vander, Allen Chiang
OBJECTIVE: To report short-term visual and anatomic outcomes of patients who were switched to aflibercept for persistent macular edema associated with central retinal vein occlusion (CRVO). METHODS: Retrospective, consecutive, interventional case series of 17 patients with persistent macular edema secondary to CRVO (defined as intraretinal edema and either <50 µm reduction in central foveal thickness [CFT] or worsening or no improvement in visual acuity [VA] compared to baseline) despite anti-VEGF treatment who were switched to aflibercept treatment...
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27743461/therapist-competencies-necessary-for-the-delivery-of-compassion-focused-therapy-a-delphi-study
#11
Alice E Liddell, Steven Allan, Ken Goss
OBJECTIVES: Compassion-focused therapy (CFT) has shown promising results for a range of clinical presentations. This study explored the therapeutic competencies required to deliver CFT and organized these into a coherent framework. DESIGN: The Delphi method was used to explore and refine competencies for delivering CFT in three rounds of data collection. METHODS: The first round involved interviews with 12 experts in CFT. Data were analysed using template analysis to generate a draft competency framework...
October 15, 2016: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/27729757/the-efficacy-of-intravitreal-aflibercept-in-submacular-hemorrhage-secondary-to-wet-age-related-macular-degeneration
#12
Kyung-Hoon Shin, Tae Gon Lee, Jae Hui Kim, Jong Woo Kim, Chul Gu Kim, Dong Won Lee, Jung Il Han, Young Ju Lew, Han Joo Cho
PURPOSE: To evaluate the efficacy of intravitreal aflibercept monotherapy in submacular hemorrhage (SMH) secondary to wet age-related macular degeneration (AMD). METHODS: This study included 25 eyes in 25 patients with SMH involving the fovea secondary to wet-AMD. All patients were treated with three consecutive monthly intravitreal aflibercept (2.0 mg/0.05 mL) injections, followed by as-needed reinjection. They were followed for at least 6 months. Best-corrected visual acuity (BCVA), central foveal thickness (CFT), and area of SMH were measured at diagnosis, as well as at 3 and 6 months after treatment initiation...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27725831/changes-in-testosterone-levels-and-sex-hormone-binding-globulin-levels-in-extremely-obese-men-after-bariatric-surgery
#13
Patchaya Boonchaya-Anant, Nitchakarn Laichuthai, Preaw Suwannasrisuk, Natnicha Houngngam, Suthep Udomsawaengsup, Thiti Snabboon
Objective. Obesity is a risk factor for hypogonadotropic hypogonadism in men. Weight loss has been shown to improve hypogonadism in obese men. This study evaluated the early changes in sex hormones profile after bariatric surgery. Methods. This is a prospective study including 29 morbidly obese men. Main outcomes were changes in serum levels of total testosterone (TT), free testosterone (cFT), SHBG, estradiol, adiponectin, and leptin at 1 and 6 months after surgery. Results. The mean age of patients was 31 ± 8 years and the mean BMI was 56...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27714896/comparing-calculated-free-testosterone-with-total-testosterone-for-screening-and-diagnosing-late-onset-hypogonadism-in-aged-males-a-cross-sectional-study
#14
Zhangshun Liu, Jie Liu, Xiaohong Shi, Lihong Wang, Yan Yang, Minfang Tao, Qiang Fu
OBJECTIVE: The aim of this study is to compare calculated free testosterone (cFT) and total testosterone (T) in predicting late-onset hypogonadism (LOH) in middle-aged and elderly males. METHODS: We surveyed a random sample of 608 males between the ages of 45 and 87 years from Shanghai, China. The Aging Male Symptoms (AMS) questionnaire and the Androgen Deficiency in Aging Male (ADAM) questionnaire were completed by the subjects. Testosterone (T), sex hormone-binding globulin (SHBG), albumin, and other blood biochemical indexes were measured in 332 males...
October 7, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27711240/reference-ranges-and-association-of-age-and-lifestyle-characteristics-with-testosterone-sex-hormone-binding-globulin-and-luteinizing-hormone-among-1166-western-chinese-men
#15
Xubo Shen, Ruifeng Wang, Na Yu, Yongjun Shi, Honggang Li, Chengliang Xiong, Yan Li, Ellen M Wells, Yuanzhong Zhou
Decreased total testosterone (TT) is the recommended metric to identify age-related hypogonadism. However, average TT and the extent to which it varies by age, can vary substantially among different populations. Population-specific reference ranges are needed to understand normal versus abnormal TT levels. Therefore, the goal for this study was to describe androgen concentrations and their correlates among Western Chinese men. We completed a population-based, cross-sectional study including 227 young adults (YA) (20-39 years) and 939 older adults (OA) (40-89 years)...
2016: PloS One
https://www.readbyqxmd.com/read/27711024/reference-intervals-of-thromboelastometric-evaluation-of-coagulation-in-pediatric-patients-with-congenital-heart-diseases-a-retrospective-investigation
#16
Ji Young Kim, Yu Rim Shin, Hae Keum Kil, Mi Ran Park, Jong Wha Lee
BACKGROUND Rotational thromboelastometry (ROTEM®) is a point-of-care test for coagulation, enabling physicians to make a swift decision. The aim of this investigation was to establish reference intervals of thromboelastometric evaluation for coagulation in pediatric patients with congenital heart diseases (CHD). MATERIAL AND METHODS As baseline data, 3 assays of ROTEM® (INTEM, EXTEM, and FIBTEM) were measured after anesthesia induction. ROTEM® parameters were clotting time (CT), amplitude at 10 min (A10), clot formation time (CFT), a angle, maximal clot firmness (MCF), clot lysis index at 60 min (LI60), and maximal clot elasticity (MCE)...
October 6, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27708366/biotransformation-of-ferulic-acid-to-vanillin-in-the-packed-bed-stirred-fermentors
#17
Lei Yan, Peng Chen, Shuang Zhang, Suyue Li, Xiaojuan Yan, Ningbo Wang, Ning Liang, Hongyu Li
We performed the biotransformation of ferulic acid to vanillin using Bacillus subtilis (B. subtilis) in the stirring packed-bed reactors filled with carbon fiber textiles (CFT). Scanning electron microscope (SEM), HPLC, qRT-PCR and ATP assay indicated that vanillin biotransformation is tightly related to cell growth, cellar activity and the extent of biofilm formation. The biotransformation was affected by hydraulic retention time (HRT), temperature, initial pH, stirring speed and ferulic acid concentration, and the maximum vanillin production was obtained at 20 h, 35 °C, 9...
October 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27707550/twenty-four-month-outcomes-of-the-ranibizumab-for-edema-of-the-macula-in-diabetes-protocol-3-with-high-dose-read-3-study
#18
Yasir J Sepah, Mohammad Ali Sadiq, David Boyer, David Callanan, Ron Gallemore, Michael Bennett, Dennis Marcus, Lawrence Halperin, Muhammad Hassan, Peter A Campochiaro, Quan Dong Nguyen, Diana V Do
PURPOSE: To compare 2.0 mg ranibizumab (RBZ) injections with 0.5 mg RBZ for eyes with center-involved diabetic macular edema (DME). DESIGN: Randomized, controlled, double-masked (to the dose), interventional, multicenter clinical trial. PARTICIPANTS: A total of 152 patients (152 eyes) with DME. METHODS: Eligible eyes were randomized in a 1:1 ratio to 0.5 mg (n = 77) or 2.0 mg (n = 75) RBZ. Study eyes received 6 monthly mandatory injections followed by as-needed injections until month 24...
October 1, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27693480/calcifying-fibrous-tumor-of-the-tunica-vaginalis-testis-a-report-of-two-cases
#19
Weiting Kang, Zilian Cui, Xudong Li, Peng Sun, Xunbo Jin
OBJECTIVE: To improve the clinical diagnosis and treatment of calcifying fibrous tumor (CFT) of the tunica vaginalis testis, we discussed clinical manifestations and pathological features of CFT. MATERIALS AND METHODS: A retrospective analysis of 2 cases of calcifying fibrous tumor that occurred in our hospital was performed, and we also reviewed the literature and research reports. RESULTS: Both patients underwent local excision with testis preservation surgery, and pathology examination confirmed the presence of multiple calcifying fibrous tumors of the tunica vaginalis testis...
September 28, 2016: Urology
https://www.readbyqxmd.com/read/27687924/evaluation-of-three-competitive-elisas-and-a-fluorescence-polarisation-assay-for-the-diagnosis-of-bovine-brucellosis
#20
A Praud, M Durán-Ferrer, D Fretin, M Jaÿ, M O'Connor, A Stournara, M Tittarelli, I Travassos Dias, B Garin-Bastuji
Bovine brucellosis is an infectious disease of worldwide public health and economic importance. The usual tests for the diagnosis of this disease include the Rose-Bengal test (RBT), complement fixation test (CFT), serum agglutination test (SAT) and indirect ELISA. New tests such as competitive ELISAs (C-ELISA) and fluorescence polarisation assay (FPA) have been developed. However, C-ELISA may correspond to different protocols and a wide variation may exist in their diagnostic performance. The aim of this study was to evaluate three commercially available C-ELISA kits (C-ELISA1-3) and FPA for the diagnosis of bovine brucellosis and compare test performance with RBT, CFT, indirect ELISA and FPA...
October 2016: Veterinary Journal
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