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https://www.readbyqxmd.com/read/28922002/behavioral-activation-strategies-for-major-depression-in-transdiagnostic-cognitive-behavioral-therapy-an-evidence-based-case-study
#1
Todd J Farchione, James F Boswell, Julianne G Wilner
Behavioral activation (BA) is a treatment approach that uses functional analysis and context-dependent strategies to enhance environmental positive reinforcement for adaptive, healthy behavior, and decrease behavioral avoidance. BA has gained considerable support for the treatment of depression and can be broadly applied across a wide range of settings and clinical populations. In this article, we provide a brief description of BA as a therapeutic behavioral strategy for depression and present a clinical case example illustrating the integration of BA with other components of a transdiagnostic cognitive-behavioral treatment for emotional disorders...
September 2017: Psychotherapy
https://www.readbyqxmd.com/read/28919774/optimizing-post-acute-care-in-breast-cancer-survivors-a-rehabilitation-perspective
#2
REVIEW
Bhasker Amatya, Fary Khan, Mary P Galea
Breast cancer (BC) is the most common malignancy and a leading cause of morbidity and mortality in women worldwide. Therapeutic advances and improved survival rates of women with BC have implications for long-term impact on disability, psychological function and quality of life (QoL), which may be amenable to rehabilitation. The focus of rehabilitation is on managing disability, reducing sequelae and symptoms, and enhancing participation and societal reintegration, to achieve the highest possible independence and the best QoL...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28919766/cognitive-behavioral-therapy-for-somatic-symptom-disorders-in-later-life-a-prospective-comparative-explorative-pilot-study-in-two-clinical-populations
#3
Michelle Jh Verdurmen, Arjan C Videler, Astrid M Kamperman, David Khasho, Christina M van der Feltz-Cornelis
BACKGROUND: Elderly patients with somatic symptom disorder (SSD) put a great burden on the health care delivery system. Cognitive behavioral therapy (CBT) is effective in adults with SSD. However, no studies have been conducted yet into CBT for SSD in later life. OBJECTIVES: We explored the feasibility of CBT for SSD in the elderly. METHODS: This is a prospective pilot study comparing two outpatient specialty mental health settings for adults (<60 years; n=13) and for elderly patients (≥60 years; n=9) with SSD...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28919388/altered-brain-functional-connectivity-induced-by-physical-exercise-may-improve-neuropsychological-functions-in-patients-with-benign-epilepsy
#4
Gyan Raj Koirala, Dongpyo Lee, Soyong Eom, Nam-Young Kim, Heung Dong Kim
OBJECTIVE: The objective of this study was to elucidate alteration in functional connectivity (FC) in patients with benign epilepsy with centrotemporal spikes (BECTS) as induced by physical exercise therapy and their correlation to the neuropsychological (NP) functions. METHODS: We analyzed 115 artifact- and spike-free 2-second epochs extracted from resting state EEG recordings before and after 5weeks of physical exercise in eight patients with BECTS. The exact Low Resolution Electromagnetic Tomography (eLORETA) was used for source reconstruction...
September 15, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28919130/the-nuts-and-bolts-of-cognitive-remediation-exploring-how-different-training-components-relate-to-cognitive-and-functional-gains
#5
Matteo Cella, Til Wykes
BACKGROUND: Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the relationship between CR ingredients, including alliance with a therapist, and therapy outcomes. METHOD: This is a secondary analysis based on data from a published randomised controlled trial comparing CR+treatment-as-usual (TAU) to TAU alone...
September 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28918315/does-cognitive-behavioural-therapy-for-insomnia-improve-cognitive-performance-a-systematic-review-and-narrative-synthesis
#6
REVIEW
Vanessa Herbert, Simon D Kyle, Daniel Pratt
Individuals with insomnia report difficulties pertaining to their cognitive functioning. Cognitive behavioural therapy for insomnia (CBT-I) is associated with robust, long-term improvements in sleep parameters, however less is known about the impact of CBT-I on the daytime correlates of the disorder. A systematic review and narrative synthesis was conducted in order to summarise and evaluate the evidence regarding the impact of CBT-I on cognitive functioning. Reference databases were searched and studies were included if they assessed cognitive performance as an outcome of CBT-I, using either self-report questionnaires or cognitive tests...
July 12, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28918081/developmental-alcohol-exposure-impairs-synaptic-plasticity-without-overtly-altering-microglial-function-in-mouse-visual-cortex
#7
Elissa L Wong, Nina M Lutz, Victoria A Hogan, Cassandra E Lamantia, Helene R McMurray, Jason R Myers, John M Ashton, Ania K Majewska
Fetal alcohol spectrum disorder (FASD), caused by gestational ethanol (EtOH) exposure, is one of the most common causes of non-heritable and life-long mental disability worldwide, with no standard treatment or therapy available. While EtOH exposure can alter the function of both neurons and glia, it is still unclear how EtOH influences brain development to cause deficits in sensory and cognitive processing later in life. Microglia play an important role in shaping synaptic function and plasticity during neural circuit development and have been shown to mount an acute immunological response to EtOH exposure in certain brain regions...
September 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28914726/pro-inflammatory-cytokines-mood-and-sleep-in-interepisode-bipolar-disorder-and-insomnia-a-pilot-study-with-implications-for-psychosocial-interventions
#8
Michael R Dolsen, Adriane M Soehner, Allison G Harvey
OBJECTIVE: Pro-inflammatory cytokines are associated with bipolar disorder (BD), but less is known about how cytokines function during the interepisode period. This study examined cytokines, mood symptoms, and sleep in individuals with interepisode BD with complaints of insomnia. We also investigated the effects of a BD-specific modification of cognitive behavior therapy for insomnia (CBTI-BP) on cytokine levels. METHODS: The 22 adults with interepisode BD Type I and insomnia were drawn from a subset of an NIMH-funded study...
September 13, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28913897/studying-the-progression-of-amyloid-pathology-and-its-therapy-using-translational-longitudinal-model-of-accumulation-and-distribution-of-amyloid-beta
#9
Tatiana Karelina, O Demin, Oleg Demin, Sridhar Duvvuri, Timothy Nicholas
Long term effects of amyloid targeted therapy can be studied using a mechanistic translational model of Aβ distribution and aggregation calibrated on published data in mouse and human species. AD pathology is modelled utilizing age-dependent pathological evolution for rate constants and several variants of explicit functions for Aβ toxicity influencing cognitive outcomes (Adas-cog). Preventive Aβ targeted therapies were simulated to minimize the Aβ difference from healthy physiological levels. Therapeutic targeted simulations provided similar predictions for mouse and human...
September 15, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28913349/brain-computer-interface-for-clinical-purposes-cognitive-assessment-and-rehabilitation
#10
REVIEW
Laura Carelli, Federica Solca, Andrea Faini, Paolo Meriggi, Davide Sangalli, Pietro Cipresso, Giuseppe Riva, Nicola Ticozzi, Andrea Ciammola, Vincenzo Silani, Barbara Poletti
Alongside the best-known applications of brain-computer interface (BCI) technology for restoring communication abilities and controlling external devices, we present the state of the art of BCI use for cognitive assessment and training purposes. We first describe some preliminary attempts to develop verbal-motor free BCI-based tests for evaluating specific or multiple cognitive domains in patients with Amyotrophic Lateral Sclerosis, disorders of consciousness, and other neurological diseases. Then we present the more heterogeneous and advanced field of BCI-based cognitive training, which has its roots in the context of neurofeedback therapy and addresses patients with neurological developmental disorders (autism spectrum disorder and attention-deficit/hyperactivity disorder), stroke patients, and elderly subjects...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28910493/using-interpersonal-process-recall-to-compare-patients-accounts-of-resistance-in-two-psychotherapies-for-generalized-anxiety-disorder
#11
Nicholas R Morrison, Michael J Constantino, Henny A Westra, Angela Kertes, Brien J Goodwin, Martin M Antony
In a trial examining whether cognitive-behavioral therapy (CBT) could be improved by integrating motivational interviewing (MI) to target resistance, MI-CBT outperformed CBT over 12-month follow-up (Westra, Constantino, & Antony, 2016). Given that effectively addressing resistance is both a theoretically and an empirically supported mechanism of MI's additive effect, we explored qualitatively patients' experience of resistance, possibly as a function of treatment. For 5 patients from each treatment who exhibited early in-session change ambivalence, and thus were at risk for later resistance, we conducted interpersonal process recall interviews after a session...
September 14, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28904603/mindfulness-based-treatment-for-bipolar-disorder-a-systematic-review-of-the-literature
#12
REVIEW
Sanja Bojic, Rodrigo Becerra
Despite the increasing number of studies examining the effects of mindfulness interventions on symptoms associated with Bipolar Disorder (BD), the effectiveness of this type of interventions remains unclear. The aim of the present systematic review was to (i) critically review all available evidence on Mindfulness Based Cognitive Therapy (MBCT) as a form of intervention for BD; (ii) discuss clinical implications of MBCT in treating patients with BD; and (iii) provide a direction for future research. The review presents findings from 13 studies (N = 429) that fulfilled the following selection criteria: (i) included BD patients; (ii) presented results separately for BD patients and control groups (where a control group was available); (iii) implemented MBCT intervention; (iv) were published in English; (v) were published in a peer reviewed journal; and (vi) reported results for adult participants...
August 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28904086/cognitive-trajectories-over-4-years-among-hiv-infected-women-with-optimal-viral-suppression
#13
Leah H Rubin, Pauline M Maki, Gayle Springer, Lorie Benning, Kathryn Anastos, Deborah Gustafson, Maria C Villacres, Xiong Jiang, Adaora A Adimora, Drenna Waldrop-Valverde, David E Vance, Hector Bolivar, Christine Alden, Eileen M Martin, Victor G Valcour
OBJECTIVE: To determine whether persistent viral suppression alters cognitive trajectories among HIV-infected (HIV+) women on combination antiretroviral therapy (cART) by investigating performance longitudinally in uninfected (HIV-) and 3 groups of HIV+ women: those with consistent viral suppression after continuous cART use (VS), those without consistent virologic suppression despite continuous cART use (NVS), and those without consistent virologic suppression after intermittent cART use (Int NVS)...
September 13, 2017: Neurology
https://www.readbyqxmd.com/read/28902564/relations-of-shared-and-unique-components-of-personality-and-psychosocial-functioning-to-depressive-symptoms
#14
Jeffrey R Vittengl, Lee Anna Clark, Michael E Thase, Robin B Jarrett
Consistent with theories of depression, several personality (e.g., high neuroticism, low extraversion) and psychosocial (e.g., interpersonal problems, cognitive content) variables predict depressive symptoms substantively. In this extended replication, we clarified whether 13 theoretically relevant personality and psychosocial variables were unique versus overlapping predictors of symptoms among 351 adult outpatients with recurrent major depressive disorder who received acute-phase cognitive therapy (CT). Using factor analysis and regression methods, we partitioned the measures' variance into general components common across the two types of measures (psychosocial and personality), within-type components shared only with other measures of the same type, and scale-specific components...
September 13, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28901528/beyond-symptomatic-effects-donepezil-s-potential-for-neuroprotection-and-disease-modification-in-alzheimer-s-disease
#15
REVIEW
Seung Hyun Kim, Nagaendran Kandiah, Jung-Lung Hsu, Chuthamanee Suthisisang, Chesda Udommongkol, Amitabh Dash
Alzheimer's disease (AD) is associated with neurodegenerative changes resulting clinically in progressive cognitive and functional deficits. The only therapies are the cholinesterase inhibitors (ChEIs) donepezil, galantamine, and rivastigmine and the N-methyl-D-aspartate-receptor antagonist memantine. Donepezil acts primarily on the cholinergic system as symptomatic treatment, but it also has potential for disease modification and may reduce the rate of progression of AD. This review explores the potential for a disease modifying effect of donepezil...
September 13, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28899788/the-translocator-protein-ligand-xbd173-improves-clinical-symptoms-and-neuropathological-markers-in-the-sjl-j-mouse-model-of-multiple-sclerosis
#16
Géraldine Leva, Christian Klein, Jérémie Benyounes, François Hallé, Frédéric Bihel, Nicolas Collongues, Jérôme De Seze, Ayikoe-Guy Mensah-Nyagan, Christine Patte-Mensah
Multiple sclerosis (MS) is a severe autoimmune disease characterized by inflammatory, demyelinating and neurodegenerative components causing motor, sensory, visual and/or cognitive symptoms. The relapsing-remitting MS affecting 85% of patients is reliably mimicked by the proteolipid-protein (PLP)-induced experimental autoimmune encephalomyelitis (EAE) SJL/J-mouse model. Significant progress was made for MS treatment but the development of effective therapies devoid of severe side-effects remains a great challenge...
September 9, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28899417/serotonin-augmentation-therapy-by-escitalopram-has-minimal-effects-on-amyloid-%C3%AE-levels-in-early-stage-alzheimer-s-like-disease-in-mice
#17
Christian Ulrich von Linstow, Jonas Waider, Manuela Grebing, Athanasios Metaxas, Klaus Peter Lesch, Bente Finsen
BACKGROUND: Dysfunction of the serotonergic (5-HTergic) system has been implicated in the cognitive and behavioural symptoms of Alzheimer's disease (AD). Accumulation of toxic amyloid-β (Aβ) species is a hallmark of AD and an instigator of pathology. Serotonin (5-HT) augmentation therapy by treatment with selective serotonin reuptake inhibitors (SSRIs) in patients with AD has had mixed success in improving cognitive function, whereas SSRI administration to mice with AD-like disease has been shown to reduce Aβ pathology...
September 12, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28895064/a-mouse-model-of-hiv-associated-neurocognitive-disorders-a-brain-behavior-approach-to-discover-disease-mechanisms-and-novel-treatments
#18
REVIEW
William R Tyor, Heather Bimonte-Nelson
HIV-associated neurocognitive disorders (HAND) remain highly prevalent despite combined antiretroviral therapy (cART). Although the most common forms of HAND are mild and identified through neuropsychological testing, there is evidence that with aging these mild forms become more prevalent and may advance to the most severe form of HAND, HIV-associated dementia. Therefore, novel therapies must be developed that can be used adjunctively with cART to prevent deterioration or restore normal cognitive function...
September 11, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28893330/changes-in-resting-state-brain-networks-after-cognitive-behavioral-therapy-for-chronic-pain
#19
A Yoshino, Y Okamoto, G Okada, M Takamura, N Ichikawa, C Shibasaki, S Yokoyama, M Doi, R Jinnin, H Yamashita, M Horikoshi, S Yamawaki
BACKGROUND: Cognitive-behavioral therapy (CBT) is thought to be useful for chronic pain, with the pathology of the latter being closely associated with cognitive-emotional components. However, there are few resting-state functional magnetic resonance imaging (R-fMRI) studies. We used the independent component analysis method to examine neural changes after CBT and to assess whether brain regions predict treatment response. METHODS: We performed R-fMRI on a group of 29 chronic pain (somatoform pain disorder) patients and 30 age-matched healthy controls (T1)...
September 12, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28891846/quality-of-life-in-rectal-cancer-patients-after-chemoradiation-watch-and-wait-policy-versus-standard-resection-a-matched-controlled-study
#20
Britt J P Hupkens, Milou H Martens, Jan H Stoot, Maaike Berbee, Jarno Melenhorst, Regina G Beets-Tan, Geerard L Beets, Stéphanie O Breukink
BACKGROUND: Fifteen to twenty percent of patients with locally advanced rectal cancer have a clinical complete response after chemoradiation therapy. These patients can be offered nonoperative organ-preserving treatment, the so-called watch-and-wait policy. The main goal of this watch-and-wait policy is an anticipated improved quality of life and functional outcome in comparison with a total mesorectal excision, while maintaining a good oncological outcome. OBJECTIVE: The aim of this study was to compare the quality of life of watch-and-wait patients with a matched-controlled group of patients who underwent chemoradiation and surgery (total mesorectal excision group)...
October 2017: Diseases of the Colon and Rectum
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