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Cow milk allergy

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https://www.readbyqxmd.com/read/29333864/non-digestible-carbohydrates-in-infant-formula-as-substitution-for-human-milk-oligosaccharide-functions-effects-on-microbiota-and-gut-maturation
#1
Renate Akkerman, Marijke M Faas, Paul de Vos
Human milk (HM) is the golden standard for nutrition of newborn infants. Human milk oligosaccharides (HMOs) are abundantly present in HM and exert multiple beneficial functions, such as support of colonization of the gut microbiota, reduction of pathogenic infections and support of immune development. HMO-composition is during lactation continuously adapted by the mother to accommodate the needs of the neonate. Unfortunately, for many valid reasons not all neonates can be fed with HM and are either totally or partly fed with cow-milk derived infant formulas, which do not contain HMOs...
January 15, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29333846/-food-allergy-in-children-recommendations-for-diagnosis-and-treatment
#2
(no author information available yet)
Food allergy arises from a specific immune response induced by food exposure. It is the first cause of anaphylaxis in childhood. Its prevalence increased exponentially in western countries. The proteins most frequently involved in infants are cow's milk and hen's egg; and in adults, seafood. Peanuts have the same frequency in both groups. The clinical manifestations and methodology of study are directly related to the pathophysiology of the disease. Clinical history, skin prick test, patch test, and food oral challenge are essential to arrive at a correct diagnosis, that will avoid unnecessary exclusions or exposures that carry life risk...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29332097/is-the-atopy-patch-test-reliable-in-the-evaluation-of-food-allergy-related-atopic-dermatitis
#3
Mahboubeh Mansouri, Elham Rafiee, Sepideh Darougar, Mehrnaz Mesdaghi, Zahra Chavoshzadeh
BACKGROUND: Aeroallergens and food allergens are found to be relevant in atopic dermatitis. The atopy patch test (APT) can help to detect food allergies in children with atopic dermatitis. This study evaluates if the APT is a valuable tool in the diagnostic workup of children with food allergy-related atopic dermatitis. METHODS: 42 children between 6 months and 12 years of age were selected at the Mofid Children Hospital. Atopic dermatitis was diagnosed, and the severity of the disease was determined...
January 13, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29329877/-attitudes-towards-cow-s-milk-protein-allergy-management-by-spanish-gastroenterologist
#4
Alicia Isabel Pascual Pérez, Alejandra Méndez Sánchez, Óscar Segarra Cantón, Beatriz Espin Jaime, Santiago Jiménez Treviño, Carlos Bousoño García, Juan José Díaz Martín
INTRODUCTION: Food allergy is an increasing health problem in the developed world. Cow's milk protein is the main cause of food allergy in infants. Without an appropriate diagnostic workup, there is a high risk of both over- and underdiagnosis and therefore, over and undertreatment. The objective of our study was to analyze the variability in cow's milk protein allergy (CMPA) management by pediatric gastroenterologists in Spain. METHODS: A fifty item questionnaire, including open and closed items in a Likert's scale from 0 to 5, was drafted and distributed through the Spanish Society for Pediatric Gastroenterology, Hepatology and Nutrition (SEGHNP) e-mail list...
January 9, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29319184/diagnostic-accuracy-risk-assessment-and-cost-effectiveness-of-component-resolved-diagnostics-for-food-allergy-a-systematic-review
#5
REVIEW
Javier Flores Kim, Nicola McCleary, Bright I Nwaru, Andrew Stoddart, Aziz Sheikh
BACKGROUND: Component-resolved diagnostics (CRD) are promising tools for diagnosing food allergy, offering the potential to determine specific phenotypes and to develop patient-tailored risk profiles. Nevertheless, the diagnostic accuracy of these tests varies across studies; thus, their clinical utility remains unclear. Therefore, we synthesized the evidence from studies investigating the diagnostic accuracy, risk assessment ability, and cost-effectiveness of CRD for food allergy. METHODS: We systematically searched 10 electronic databases and four clinical trial registries for studies published January 2000-February 2017...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29315919/prevalence-and-longitudinal-trends-of-food-allergy-during-childhood-and-adolescence-results-of-the-isle-of-wight-birth-cohort-study
#6
D Venkataraman, M Erlewyn-Lajeunesse, R J Kurukulaaratchy, S Potter, G Roberts, S Matthews, S Hasan Arshad
BACKGROUND: The prevalence and time trends of food allergy change during childhood depending on the age of the child and the type of food. OBJECTIVE: To study prevalence and longitudinal trends in food allergy from birth to 18 years in an unselected birth cohort in the Isle of Wight. METHOD: Information on food allergy was collected at ages 1, 2, 4, 10 and 18 years from the Isle of Wight Birth Cohort (n = 1456). Skin prick testing (SPT) was performed at the age of 1 and 2 years in symptomatic children...
January 8, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29314279/cow-s-milk-allergic-children-can-component-resolved-diagnostics-predict-duration-and-severity
#7
Thomas Houmann Petersen, Charlotte Gotthard Mortz, Carsten Bindslev-Jensen, Esben Eller
BACKGROUND: Cow's Milk Allergy (CMA) affects 2% of all children. This study investigates CRD to cow's milk proteins in children suspected for CMA, by correlating the level of CRD with outcome of the oral challenge. Furthermore, we evaluate the ability of serial CRD measurements to distinguish children with persistent CMA from children developing tolerance. METHODS: We included data from 78 children referred to the Allergy Centre during a 13 years period. Results from oral food challenges including threshold, severity and sensitization data (IgE antibodies to whole milk protein, IgE components towards milk and skin prick test (SPT)) were collected...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29279061/characteristics-of-beef-allergy-in-schoolchildren-in-turkey
#8
Zekiye İlke Kılıç Topçu, Neşe Kaklıkkaya, Ali Baki, Fazıl Orhan
BACKGROUND: The prevalence of immunoglobulin E (IgE) mediated beef allergy in childhood is unknown. We investigated the prevalence and characteristics of IgE-mediated beef allergy in urban schoolchildren. METHODS: This cross-sectional study recruited 6000 randomly selected urban schoolchildren ages 6-17 years from the city center of Giresun in the eastern Black Sea region of Turkey during 2013. Children with suspected IgE-mediated beef allergy, determined by a self-administered questionnaire, after providing written consent, were skin-prick tested with commercial beef and cow's milk solutions and prick-prick tested with raw, boiled, and fried beef...
January 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29248387/the-prevalence-of-food-sensitization-appears-not-to-have-changed-between-2-melbourne-cohorts-of-high-risk-infants-recruited-15-years-apart
#9
Rachel L Peters, Jennifer J Koplin, Katrina J Allen, Adrian J Lowe, Caroline J Lodge, Mimi L K Tang, Melissa Wake, Anne-Louise Ponsonby, Bircan Erbas, Michael J Abramson, David Hill, Lyle C Gurrin, Shyamali C Dharmage
BACKGROUND: Although food allergy has probably risen over recent decades, recent reports suggest that the prevalence of food sensitization in the general population has not changed. However, this has not been analyzed in infants at high risk of food allergy. OBJECTIVE: The objective of this study was to compare the prevalence of food sensitization in high-risk infants from 2 cohorts recruited 15 years apart in the same region. METHODS: This study includes 620 high-risk infants with a family history of allergy (Melbourne Atopy Cohort Study [MACS]) born 1990-1994, and a subgroup of high-risk infants from the population-based HealthNuts study (n = 3,661/5,276), born 2006-2010...
December 13, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29234055/oral-immunotherapy-combined-with-omalizumab-for-high-risk-cow-s-milk-allergy-a-randomized-controlled-trial
#10
Masaya Takahashi, Kazuhiko Soejima, Shoichiro Taniuchi, Yasuko Hatano, Sohsaku Yamanouchi, Hideki Ishikawa, Makoto Irahara, Youhei Sasaki, Hiroshi Kido, Kazunari Kaneko
We evaluated the efficacy and safety of oral immunotherapy (OIT) combined with 24 weeks of omalizumab (OMB) at inducing desensitization in children with cow's milk allergy (CM) compared with an untreated group. The present study was a prospective randomized controlled trial. Sixteen patients (age, 6-14 years) with high IgE levels to CM were enrolled in the present study. Patients were randomized 1:1 to receive OMB-OIT group or untreated group. The primary outcome was the induction of desensitization at 8 weeks after OMB was discontinued in OMB-OIT treated group and at 32 weeks after study entry...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29223706/cross-over-clinical-trial-for-evaluating-the-safety-of-camel-s-milk-intake-in-patients-who-are-allergic-to-cow-s-milk-protein
#11
E M Navarrete-Rodríguez, L A Ríos-Villalobos, C R Alcocer-Arreguín, B E Del-Rio-Navarro, J M Del Rio-Chivardi, O J Saucedo-Ramírez, J J L Sienra-Monge, R V Frias
BACKGROUND: Cow's milk protein allergy (CMPA) affects between 0.6 and 0.9% of the general population, and its treatment implies the total elimination of the intake of this protein. Camel's milk has been suggested as an alternative for patients over one year of age who suffer from CMPA due to the difference in the amino acid sequence from that of cow's milk. The objective of this study was to evaluate the safety and tolerability of camel's milk in children with CMPA. METHODS: Crossed clinical trial for the use of camel's milk vs...
December 6, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29220053/the-mechanism-of-reduced-igg-ige-binding-of-%C3%AE-lactoglobulin-by-pulsed-electric-field-pretreatment-combined-with-glycation-revealed-by-ecd-fticr-ms
#12
Wenhua Yang, Zongcai Tu, Hui Wang, Lu Zhang, Igor A Kaltashov, Yunlong Zhao, Chendi Niu, Honglin Yao, Wenfeng Ye
Bovine β-lactoglobulin (β-Lg) is a major allergen existing in milk and causes about 90% of IgE-mediated cow's milk allergies. Previous studies showed that pulsed electric field (PEF) treatment could partially unfold the protein, which may contribute to the improvement of protein glycation. In this study, the effect of PEF pretreatment combined with glycation on the IgG/IgE-binding ability and the structure of β-Lg was investigated. The result showed that PEF pretreatment combined with glycation significantly reduced the IgG and IgE binding abilities, which was attributed to the changes of secondary and tertiary structure and the increase in glycation sites and degree of substitution per peptide (DSP) value determined by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD/FTICR-MS)...
December 8, 2017: Food & Function
https://www.readbyqxmd.com/read/29218832/necrotizing-enterocolitis-in-the-setting-of-milk-allergy-after-pediatric-living-donor-liver-transplantation
#13
Soichi Narumoto, Seisuke Sakamoto, Hajime Uchida, Kengo Sasaki, Takanobu Shigeta, Akinari Fukuda, Shunsuke Nosaka, Rie Irie, Takako Yoshioka, Mureo Kasahara
NEC is an idiopathic intestinal mucosal injury that may progress to transmural bowel necrosis without mesenteric ischemia. NEC usually affects 7- to 10-day-old neonates following enteral feeding. A 10-month-old girl with no history of laparotomy underwent LDLT for acute liver failure. After starting enteral feeding on postoperative day 5, she developed abdominal distention. Diffuse PVG and PI were detected by radiologic modalities. Exploratory laparotomy revealed patchy necrosis of the intestine without perforation...
December 7, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29210890/allergic-colitis-with-pneumatosis-intestinalis-in-an-infant
#14
Helena Liu, Troy W S Turner
Inflammatory causes of bloody diarrhea during infancy include necrotizing enterocolitis and allergic colitis, often due to cow's milk protein. We report this case of cow's milk protein allergy, managed successfully with elimination of dietary antigen, to highlight the unusual finding of pneumatosis intestinalis on abdominal x-ray, a radiographic hallmark associated with necrotizing enterocolitis. Detailed patient's history, clinical presentation, and physical examinations are discussed for cow's milk protein allergy and necrotizing enterocolitis...
November 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29205393/eaaci-guidelines-on-allergen-immunotherapy-ige-mediated-food-allergy
#15
G B Pajno, M Fernandez-Rivas, S Arasi, G Roberts, C A Akdis, M Alvaro-Lozano, K Beyer, C Bindslev-Jensen, W Burks, M Ebisawa, P Eigenmann, E Knol, K C Nadeau, L K Poulsen, R van Ree, A F Santos, G du Toit, S Dhami, U Nurmatov, Y Boloh, M Makela, L O'Mahony, N Papadopoulos, C Sackesen, I Agache, E Angier, S Halken, M Jutel, S Lau, O Pfaar, D Ryan, G Sturm, E-M Varga, R G van Wijk, A Sheikh, A Muraro
Food allergy can result in considerable morbidity, impairment of quality of life, and healthcare expenditure. There is therefore interest in novel strategies for its treatment, particularly food allergen immunotherapy (FA-AIT) through the oral (OIT), sublingual (SLIT), or epicutaneous (EPIT) routes. This Guideline, prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Task Force on Allergen Immunotherapy for IgE-mediated Food Allergy, aims to provide evidence-based recommendations for active treatment of IgE-mediated food allergy with FA-AIT...
September 27, 2017: Allergy
https://www.readbyqxmd.com/read/29202914/integrating-allergen-analysis-within-a-risk-assessment-framework-approaches-to-development-of-targeted-mass-spectrometry-methods-for-allergen-detection-and-quantification-in-the-ifaam-project
#16
Chiara Nitride, Victoria Lee, Ivona Baricevic-Jones, Karine Adel-Patient, Sabine Baumgartner, E N Clare Mills
Allergen analysis is central to implementing and monitoring food allergen risk assessment and management processes by the food industry, but current methods for the determination of allergens in foods give highly variable results. The European Union-funded "Integrated Approaches to Food Allergen and Allergy Risk Management" (iFAAM) project has been working to address gaps in knowledge regarding food allergen management and analysis, including the development of novel MS and immuno-based allergen determination methods...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29176842/allergenic-food-introduction-and-risk-of-childhood-atopic-diseases
#17
Niels J Elbert, Jessica C Kiefte-de Jong, Trudy Voortman, Tamar E C Nijsten, Nicolette W de Jong, Vincent W V Jaddoe, Johan C de Jongste, Roy Gerth van Wijk, Liesbeth Duijts, Suzanne G M A Pasmans
BACKGROUND: The role of timing and diversity of allergenic food introduction in the development of childhood allergic sensitization and atopic diseases is controversial. OBJECTIVE: To examine whether timing and diversity of allergenic food introduction are associated with allergic sensitization, allergy and eczema in children until age 10 years. MATERIALS AND METHODS: This study among 5,202 children was performed in a population-based prospective cohort...
2017: PloS One
https://www.readbyqxmd.com/read/29169718/-update-on-dietary-management-of-cow-s-milk-allergy
#18
C Dupont, P Soulaines
Dietary management of cow's milk allergy is based on the elimination of all cow's milk proteins from the diet. For non-breastfed infants, the main dietetic move is the replacement of the standard infant formula with a formula for which the protein fraction has been modified. This formula can be based on hydrolyzed cow's milk proteins, rice proteins or amino acids. Monitoring the growth of these children is essential. The reintroduction of cow's milk, raw or heated, should always be made carefully and gradually...
November 20, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29161056/de-novo-food-allergy-in-pediatric-liver-transplantation-recipients
#19
Ratchaneewan Sinitkul, Wiparat Manuyakorn, Wasu Kamchaisatian, Soamarat Vilaiyuk, Suwat Benjaponpitak, Chatmanee Lertudompholwanit, Suporn Treepongkaruna
BACKGROUND: Food allergy (FA) prevalence is increasing in pediatric liver transplantation (LT). However, the clinical course is still limited. OBJECTIVE: This retrospective cohort study aimed to identify the prevalence, risk factors, and the natural history of de novo FA in children post LT. METHODS: Medical records of pediatric LT recipients from Jan 2001 - Dec 2014 were reviewed. De novo FA was diagnosed by symptoms after exposure to culprit food occurring after LT, and improvement after diet elimination...
November 22, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29155807/a-synbiotic-containing-amino-acid-based-formula-improves-gut-microbiota-in-non-ige-mediated-allergic-infants
#20
David C A Candy, Marleen T J Van Ampting, Manon M Oude Nijhuis, Harm Wopereis, Assad M Butt, Diego G Peroni, Yvan Vandenplas, Adam T Fox, Neil Shah, Christina E West, Johan Garssen, Lucien F Harthoorn, Jan Knol, Louise J Michaelis
BACKGROUND: Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino acid-based formula (AAF) for infants with cow's milk allergy (CMA). METHODS: This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA...
November 20, 2017: Pediatric Research
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