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Inflammation polyphenols

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https://www.readbyqxmd.com/read/28732012/multi-approach-metabolomics-analysis-and-artificial-simplified-phytocomplexes-reveal-cultivar-dependent-synergy-between-polyphenols-and-ascorbic-acid-in-fruits-of-the-sweet-cherry-prunus-avium-l
#1
Mauro Commisso, Martino Bianconi, Flavia Di Carlo, Stefania Poletti, Alessandra Bulgarini, Francesca Munari, Stefano Negri, Matteo Stocchero, Stefania Ceoldo, Linda Avesani, Michael Assfalg, Gianni Zoccatelli, Flavia Guzzo
Fruits of the sweet cherry (Prunus avium L.) accumulate a range of antioxidants that can help to prevent cardiovascular disease, inflammation and cancer. We tested the in vitro antioxidant activity of 18 sweet cherry cultivars collected from 12 farms in the protected geographical indication region of Marostica (Vicenza, Italy) during two growing seasons. Multiple targeted and untargeted metabolomics approaches (NMR, LC-MS, HPLC-DAD, HPLC-UV) as well as artificial simplified phytocomplexes representing the cultivars Sandra Tardiva, Sandra and Grace Star were then used to determine whether the total antioxidant activity reflected the additive effects of each compound or resulted from synergistic interactions...
2017: PloS One
https://www.readbyqxmd.com/read/28726741/magnolol-a-natural-polyphenol-attenuates-dextran-sulfate-sodium-induced-colitis-in-mice
#2
Ling Zhao, Hai-Tao Xiao, Huai-Xue Mu, Tao Huang, Ze-Si Lin, Linda L D Zhong, Guang-Zhi Zeng, Bao-Min Fan, Cheng-Yuan Lin, Zhao-Xiang Bian
Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7 days. The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shortening, reduced colonic lesions and suppressed myeloperoxidase (MPO) activity...
July 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28721824/potential-anti-inflammatory-effects-of-hesperidin-from-the-genus-citrus
#3
Silvia Tejada, Samuel Pinya, Miquel Martorell, Xavier Capó, Josep A Tur, Antoni Pons, Antoni Sureda
The benefits of the Mediterranean diet for protecting against many diseases are usually attributed to high consumption of certain foods, characterized by the presence of bioactive substances such as polyphenols. Citrus fruits, which are cultivated and consumed worldwide, are typical products of the Mediterranean diet. Inflammation plays an important role in the pathogenesis of numerous diseases such as arthritis, allergies and neurodegenerative disorders, among others. Dietary polyphenols constitute a large family of bioactive substances with potential beneficial effects against a broad group of diseases...
July 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28696985/tart-cherry-juice-in-athletes-a-literature-review-and-commentary
#4
Kenneth C Vitale, Shawn Hueglin, Elizabeth Broad
Tart cherry (TC) juice has many antioxidant and anti-inflammatory polyphenol compounds. TC lessens pain and accelerates strength recovery after exercise and decreases blood markers of inflammation/oxidative stress. These improvements occur in both strength and endurance exercise. TC supplementation may not be optimal during the adaptation/build stage of training. However, excessive inflammatory/oxidative stress during single-day intense training/competition or multiday tournaments may delay return to peak form...
July 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28695536/molecular-mechanisms-underlying-the-anti-depressant-effects-of-resveratrol-a-review
#5
REVIEW
Marcos Roberto de Oliveira, Aline Lukasievicz Chenet, Adriane Ribeiro Duarte, Giselli Scaini, João Quevedo
Major depression is a public health problem, affecting 121 million people worldwide. Patients suffering from depression present high rates of morbidity, causing profound economic and social impacts. Furthermore, patients with depression present cognitive impairments, which could influence on treatment adherence and long-term outcomes. The pathophysiology of major depression is not completely understood yet but involves reduced levels of monoamine neurotransmitters, bioenergetics, and redox disturbances, as well as inflammation and neuronal loss...
July 10, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28680065/nopal-opuntia-ficus-indica-protects-from-metabolic-endotoxemia-by-modifying-gut-microbiota-in-obese-rats-fed-high-fat-sucrose-diet
#6
Mónica Sánchez-Tapia, Miriam Aguilar-López, Claudia Pérez-Cruz, Edgar Pichardo-Ontiveros, Mei Wang, Sharon M Donovan, Armando R Tovar, Nimbe Torres
Current efforts are directed to reducing the gut dysbiosis and inflammation produced by obesity. The purpose of this study was to investigate whether consuming nopal, a vegetable rich in dietary fibre, vitamin C, and polyphenols can reduce the metabolic consequences of obesity by modifying the gut microbiota and preventing metabolic endotoxemia in rats fed a high fat and sucrose diet. With this aim, rats were fed a high fat diet with 5% sucrose in the drinking water (HFS) for 7 months and then were fed for 1 month with HFS + 5% nopal (HFS + N)...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28678204/anti-inflammatory-and-anti-urolithiasis-effects-of-polyphenolic-compounds-from-quercus-gilva-blume
#7
Sung Hye Youn, Joo Hee Kwon, Jun Yin, Le Thi Tam, Hye Shin Ahn, Soon Chul Myung, Min Won Lee
Quercus gilva Bume (QGB, family Fagaceae) is a tall evergreen oak species tree that grows in warm temperate regions in Korea, Japan, China and Taiwan. Quercus plants have long been the basis of traditional medicines. Their clinical benefits according to traditional medicine include relief of urolithiasis, tremors and inflammation. In the present study, the anti-urolithiasis activity including anti-inflammatory and anti-oxidative activities, of some phenolic compounds isolated from QGB were described. Seven compounds were isolated and identified as picraquassioside D (1), quercussioside (2), (+)-lyoniresinol-9'α-O-β-d-xylopyranoside (3), (+)-catechin (4), (-)-epicatechin (5), procyanidin B-3 (6), and procyanidin B-4 (7)...
July 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28677319/effect-of-the-polyphenol-rich-ethyl-acetate-fraction-from-the-leaves-of-lycium-chinense-miller-on-oxidative-stress-dyslipidemia-and-diabetes-mellitus-in-streptozotocin-nicotinamide-induced-diabetic-rats
#8
Opeyemi J Olatunji, Hongxia Chen, Yifeng Zhou
Lycium chinense Miller, popularly known as boxthorn, is a plant that is traditionally used for treating night sweat, cough, inflammation and diabetes mellitus. However, the leaves have received little or no attention despite their potentials as a potent therapeutic agent. This study was aimed at investigating the hypoglycemic and hypolipidemic effects of the polyphenols-rich ethyl acetate fraction from the leaves of Lycium chinense Miller on streptozotocin-nicotinamide induced diabetic rats. The ethyl acetate fraction (LFE) was selected and orally gavaged at 100, 200 and 400 mg/kg dose to streptozotocin (STZ)-nicotinamide induced diabetic rats...
July 4, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28676015/effects-of-resveratrol-and-other-polyphenols-on-sirt1-relevance-to-brain-function-during-aging
#9
F Sarubbo, S Esteban, A Miralles, D Moranta
Classically the oxidative stress and more recently inflammatory processes have been identified as the major causes of brain aging. Oxidative stress and inflammation affect each other, but there is more information about the effects of oxidative stress on aging than regarding the contribution of inflammation on it. In the intense research for methods to delay or mitigate the effects of aging, are interesting polyphenols, natural molecules synthesized by plants (e.g. resveratrol). Their antioxidant and anti-inflammatory properties become them useful molecules in the prevention of aging...
July 3, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28666294/epigallocatechin-3-gallate-protects-against-homocysteine-induced-brain-damage-in-rats
#10
Lili Wang, Xuan Tian
High levels of homocysteine are implicated in many neurovascular and neurodegeneration diseases. Epigallocatechin 3-gallate (EGCG), one of green tea polyphenols, has potential anti-oxidative and anti-inflammatory activities. However, it has not been explored whether EGCG has an effect on homocysteine-induced neuro-inflammation and neurodegeneration. In this study, we investigated the effects of EGCG on memory deficit, oxidative stress, neuro-inflammation, and neurodegeneration in hyper-homocysteinemic rats after a 2 wk homocysteine injection by vena caudalis...
June 30, 2017: Planta Medica
https://www.readbyqxmd.com/read/28661454/chlorogenic-acid-ameliorates-experimental-colitis-by-promoting-growth-of-akkermansia-in-mice
#11
Zhan Zhang, Xinyue Wu, Shuyuan Cao, Meghan Cromie, Yonghua Shen, Yiming Feng, Hui Yang, Lei Li
Chlorogenic acid (ChA)-one of the most abundant polyphenol compounds in the human diet-exerts anti-inflammatory activities. The aim of this study was to investigate the effect of ChA on gut microbiota in ulcerative colitis (UC). Colitis was induced by 2.5% dextran sulfate sodium (DSS) in C57BL/6 mice, which were on a control diet or diet with ChA (1 mM). The histopathological changes and inflammation were evaluated. Fecal samples were analyzed by 16S rRNA gene sequencing. ChA attenuated several effects of DSS-induced colitis, including weight loss, increased disease activity index, and improved mucosal damage...
June 29, 2017: Nutrients
https://www.readbyqxmd.com/read/28659745/protective-effects-of-tea-polyphenols-on-exhaustive-exercise-induced-fatigue-inflammation-and-tissue-damage
#12
Lixia Liu, Xiuqin Wu, Bingchen Zhang, Wei Yang, Daliang Li, Yanqiu Dong, Yujiao Yin, Qi Chen
Background: The beneficial properties of tea polyphenols have been extensively studied; however, less attention has been paid to their effects, especially anti-inflammatory effect during exhaustive exercise. Objective: The present study assessed the potential protective effects of tea polyphenols against the fatigue, inflammation and tissue injury caused by an exhaustive exercise bout in rats. Design: Twenty-four healthy male rats were divided into three groups. Group C was a sedentary control group, Groups E+TP and Group E performed a single exhaustive swimming test; all groups had normal diets, but Group E+TP was supplemented with tea polyphenols...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28649250/immunity-in-protochordates-the-tunicate-perspective
#13
REVIEW
Nicola Franchi, Loriano Ballarin
Tunicates are the closest relatives of vertebrates, and their peculiar phylogenetic position explains the increasing interest toward tunicate immunobiology. They are filter-feeding organisms, and this greatly influences their defense strategies. The majority of the studies on tunicate immunity were carried out in ascidians. The tunic acts as a first barrier against pathogens and parasites. In addition, the oral siphon and the pharynx represent two major, highly vascularized, immune organs, where circulating hemocytes can sense non-self material and trigger immune responses that, usually, lead to inflammation and phagocytosis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28644019/metabolomics-analysis-to-evaluate-the-anti-inflammatory-effects-of-polyphenols-glabridin-reversed-metabolism-change-caused-by-lps-in-raw-264-7-cells
#14
Kaiqin Liu, Fuwei Pi, Hongxia Zhang, Jian Ji, Shuang Xia, Fangchao Cui, Jiadi Sun, Xiulan Sun
Inflammation has been shown to play a critical role in the development of many diseases. In this study, we used metabolomics to evaluate the inflammatory effect of lipopolysaccharide (LPS) and the anti-inflammatory effect of glabridin (GB, a polyphenol from Glycurrhiza glabra L. roots) in RAW 264.7 cells. Multivariate statistical analysis showed that in comparison with the LPS group, the metabolic profile of the GB group was more similar to that of the control group. LPS impacted the amino acid, energy, and lipid metabolisms in RAW 264...
July 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28643853/qualitative-analysis-of-polyphenols-in-macroporous-resin-pretreated-pomegranate-husk-extract-by-hplc-qtof-ms
#15
Rahima Abdulla, Sanawar Mansur, Haizhong Lai, Ablikim Ubul, Guangying Sun, Guozheng Huang, Haji Akber Aisa
INTRODUCTION: Pomegranate (Punica granatum L.) husk is a traditional herbal medicine abundant in phenolic compounds and plays some roles in the treatment of oxidative stress, bacterial and viral infection, diabetes mellitus, and acute and chronic inflammation. OBJECTIVE: Identification and determination of polyphenols in macroporous resin pretreated pomegranate husk extract by high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF-MS)...
June 23, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28629073/in-vitro-and-in-vivo-anti-inflammatory-properties-of-green-synthesized-silver-nanoparticles-using-viburnum-opulus-l-fruits-extract
#16
Bianca Moldovan, Luminita David, Adriana Vulcu, Liliana Olenic, Maria Perde-Schrepler, Eva Fischer-Fodor, Ioana Baldea, Simona Clichici, Gabriela Adriana Filip
A green, rapid and cost effective method for the bio-synthesis of silver nanoparticles (AgNPs), using polyphenols present in European cranberry bush fruit extracts was developed. The obtained AgNPs were characterized by ultra-violet visible spectroscopy (UV-VIS), Fourier transform - infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray diffraction patterns (XRD). The average size of the spherical AgNPs was found to be 25nm. The anti-inflammatory effect of the biomaterials was investigated, both in vitro (on HaCaT cell line, exposed to UVB radiation) and in vivo (on acute inflammation model in Wistar rats)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28609844/an-overview-on-immunoregulatory-and-anti-inflammatory-properties-of-chrysin-and-flavonoids-substances
#17
REVIEW
Majid Zeinali, Seyed Abdolrahim Rezaee, Hossein Hosseinzadeh
Inflammation and the pro-inflammatory cytokines are associated with numerous chronic diseases. Studies suggest that flavonoids, plant polyphenolic compound derivatives from natural origin, have a wide range of putative biological activities. Similar to other flavonoids, chrysin (CH) by its anti-oxidative and anti-inflammatory effects is a potential prophylactic agent in immunopathological and physicochemical injuries. This is an overview on putative immunomodulatory activities of flavonoids and beneficial health effects of these substances particularly, CH in the immune system...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28608557/salicornia-extract-ameliorates-salt-induced-aggravation-of-nonalcoholic-fatty-liver-disease-in-obese-mice-fed-a-high-fat-diet
#18
Jae Hwan Kim, Sujin Suk, Woo Jung Jang, Chang Hyung Lee, Jong-Eun Kim, Jin-Kyu Park, Mee-Hyang Kweon, Jong Hun Kim, Ki Won Lee
High-fat and high-salt intakes are among the major risks of chronic diseases including obesity, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis (NASH). Salicornia is a halophytic plant known to exert antioxidant, antidiabetic, and hypolipidemic effects, and Salicornia-extracted salt (SS) has been used as a salt substitute. In this study, the effects of SS and purified salt (PS) on the aggravation of NAFLD/NASH were compared. C57BL/6J male mice (8-wk-old) were fed a high-fat diet (HFD) for 6 mo and divided into 3 dietary groups, which were additionally fed HFD, HFD + SS, and HFD + PS for 13 wk...
July 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28608449/resveratrol-suppresses-lipoprotein-associated-phospholipase-a2-expression-by-reducing-oxidative-stress-in-macrophages-and-animal-models
#19
Shengnan Sun, Mingjun Zhang, Qiangbing Yang, Ziying Shen, Jiahuan Chen, Biao Yu, He Wang, Jiali Qu, Daxin Pang, Wenzhi Ren, Hongsheng Ouyang, Xiaochun Tang
SCOPE: Resveratrol is a naturally occurring polyphenolic compound with known cardioprotective, anti-inflammatory and antioxidant properties. Lipoprotein-associated phospholipase A2 (Lp-PLA2 ) is associated with the risk of cardiovascular disease. Here, we investigated the effects of resveratrol on Lp-PLA2 expression in vitro and in vivo and explored the underlying mechanisms. METHODS AND RESULTS: Human monocytic cells (THP-1) were induced to differentiate into macrophages for an in vitro experimental model...
June 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28595952/trans-resveratrol-enriched-maternal-diet-protects-the-immature-hippocampus-from-perinatal-asphyxia-in-rats
#20
Sebastian Isac, Anca Maria Panaitescu, Ana Spataru, Mara Iesanu, Alexandra Totan, Amalia Udriste, Natalia Cucu, Gheorghe Peltecu, Leon Zagrean, Ana-Maria Zagrean
Trans-resveratrol (tRESV), a polyphenol with antioxidant properties, is common in many food sources, hence easily accessible for study as a maternal dietary supplement in perinatal asphyxia (PA). Hypoxic-ischemic encephalopathy secondary to PA affects especially vulnerable brain areas such as hippocampus and is a leading cause of neonatal morbidity. The purpose of this study is to identify new epigenetic mechanisms of brain inflammation and injury related to PA and to explore the benefit of tRESV enriched maternal diet...
July 13, 2017: Neuroscience Letters
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