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Inflammation polyphenols

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https://www.readbyqxmd.com/read/27912886/medicinal-plants-and-natural-molecules-with-in-vitro-and-in-vivo-activity-against-rotavirus-a-systematic-review
#1
REVIEW
Gopalsamy Rajiv Gandhi, Paula Gurgel Barreto, Bruno Dos Santos Lima, Jullyana de Souza Siqueira Quintans, Adriano Antunes de Souza Araújo, Narendra Narain, Lucindo Jose Quintans-Júnior, Ricardo Queiroz Gurgel
BACKGROUND: Rotaviruses can cause life-threatening health disorders, such as severe dehydrating gastroenteritis and diarrhea in children. Vaccination is the main preventive strategy to reduce rotavirus diarrhea and the severity of episodes, but vaccines are not fully effective and new episodes may occur, even in vaccinated children. The WHO recommends oral rehydration therapy and zinc supplementation for rotavirus-induced diarrhea management. There is little preclinical evidence to support the use of phytotherapeutics in the management of rotaviral infections...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27907087/prenylated-polyphenols-from-clusiaceae-and-calophyllaceae-with-immunomodulatory-activity-on-endothelial-cells
#2
Caroline Rouger, Sylvain Pagie, Séverine Derbré, Anne-Marie Le Ray, Pascal Richomme, Béatrice Charreau
Endothelial cells (ECs) are key players in inflammation and immune responses involved in numerous pathologies. Although attempts were experimentally undertaken to prevent and control EC activation, drug leads and probes still remain necessary. Natural products (NPs) from Clusiaceous and Calophyllaceous plants were previously reported as potential candidates to prevent endothelial dysfunction. The present study aimed to identify more precisely the molecular scaffolds that could limit EC activation. Here, 13 polyphenols belonging to 5 different chemical types of secondary metabolites (i...
2016: PloS One
https://www.readbyqxmd.com/read/27905107/co-operative-suppression-of-inflammatory-responses-in-human-dendritic-cells-by-plant-proanthocyanidins-and-products-from-the-parasitic-nematode-trichuris-suis
#3
Andrew R Williams, Elsenoor J Klaver, Lisa C Laan, Aina Ramsay, Christos Fryganas, Rolf Difborg, Helene Kringel, Jess D Reed, Irene Mueller-Harvey, Søren Skov, Irma van Die, Stig M Thamsborg
Interactions between dendritic cells (DCs) and environmental, dietary and pathogen antigens play a key role in immune homeostasis and regulation of inflammation. Dietary polyphenols such as proanthocyanidins (PAC) may reduce inflammation, and we therefore hypothesized that PAC may suppress lipopolysaccharide (LPS) -induced responses in human DCs and subsequent T helper type 1 (Th1) -type responses in naive T cells. Moreover, we proposed that, because DCs are likely to be exposed to multiple stimuli, the activity of PAC may synergise with other bioactive molecules that have anti-inflammatory activity, e...
November 7, 2016: Immunology
https://www.readbyqxmd.com/read/27889107/combination-of-the-anthocyanidins-malvidin-and-peonidin-attenuates-lipopolysaccharide-mediated-inflammatory-gene-expression-in-primary-human-adipocytes
#4
Jessica D Mackert, Michael K McIntosh
We recently demonstrated that California table grapes and a methanol-extractable, polyphenol-rich fraction decreased adiposity, insulin resistance, or markers of inflammation in high-fat fed mice. Malvidin and peonidin glycosides were the 2 most abundant anthocyanins in the polyphenol-rich fraction. We hypothesized that a blood borne combination of anthocyanidins malvidin and peonidin derived from intestinal β-glycosidase metabolism of these 2 anthocyanins are responsible, in part, for the beneficial health effects observed in vivo...
November 10, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27888116/hpv16-induces-a-wasting-syndrome-in-transgenic-mice-amelioration-by-dietary-polyphenols-via-nf-%C3%AE%C2%BAb-inhibition
#5
Rui M Gil da Costa, Sofia Aragão, Magda Moutinho, Antonieta Alvarado, Diogo Carmo, Fátima Casaca, Sandra Silva, Joana Ribeiro, Hugo Sousa, Rita Ferreira, Rita Nogueira-Ferreira, Maria João Pires, Bruno Colaço, Carlos Venâncio, Maria Manuel Oliveira, Margarida M S M Bastos, Carlos Lopes, Paula A Oliveira
Cancer patients often show a wasting syndrome for which there are little therapeutic options. Dietary polyphenols have been proposed for treating this syndrome, but their usefulness in cases associated with human papillomavirus (HPV)-induced cancers is unknown. We characterized HPV16-transgenic mice as a model of cancer cachexia and tested the efficacy of long-term oral supplementation with polyphenols curcumin and rutin. Both compounds were orally administered to six weeks-old HPV16-transgenic mice showing characteristic multi-step skin carcinogenesis, for 24weeks...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27865620/consumption-of-chokeberry-aronia-mitschurinii-products-modestly-lowered-blood-pressure-and-reduced-low-grade-inflammation-in-patients-with-mildly-elevated-blood-pressure
#6
Britt-Marie Loo, Iris Erlund, Raika Koli, Pauli Puukka, Jarkko Hellström, Kristiina Wähälä, Pirjo Mattila, Antti Jula
Previous studies suggest that consumption of chokeberries may improve cardiovascular disease risk factor profiles. We hypothesized that chokeberries (Aronia mitschurinii) have beneficial effects on blood pressure, low-grade inflammation, serum lipids, serum glucose, and platelet aggregation in patients with untreated mild hypertension. A total of 38 participants were enrolled into a 16-week single blinded crossover trial. The participants were randomized to use cold-pressed 100% chokeberry juice (300 mL/d) and oven-dried chokeberry powder (3 g/d), or matched placebo products in random order for 8 weeks each with no washout period...
September 14, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27865612/changes-in-intestinal-immunity-gut-microbiota-and-expression-of-energy-metabolism-related-genes-explain-adenoma-growth-in-bilberry-and-cloudberry-fed-apc-min-mice
#7
Essi Päivärinta, Mikael Niku, Johanna Maukonen, Markus Storvik, Anu Heiman-Lindh, Maria Saarela, Anne-Maria Pajari, Marja Mutanen
We showed previously that ellagitannin-rich cloudberries and anthocyanin-rich bilberries reduce the number of intestinal adenomas in multiple intestinal neoplasia/+ (Apc(Min)) mice. We also found that cloudberries decreased the size of adenomas, whereas bilberries increased it. Here we hypothesized that the difference in adenoma growth could be explained by dissimilar effects of the berries on intestinal immune responses and gut microbiota, potentially driven by the distinct polyphenol compositions of the 2 berries...
October 15, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27846826/natural-product-htp-screening-for-antibacterial-e-coli-0157-h7-and-anti-inflammatory-agents-in-lps-from-e-coli-o111-b4-activated-macrophages-and-microglial-cells-focus-on-sepsis
#8
Elizabeth A Mazzio, Nan Li, David Bauer, Patricia Mendonca, Equar Taka, Mohammed Darb, Leeshawn Thomas, Henry Williams, Karam F A Soliman
BACKGROUND: Acute systemic inflammatory response syndrome arising from infection can lead to multiple organ failure and death, with greater susceptibility occurring in immunocompromised individuals. Moreover, sub-acute chronic inflammation is a contributor to the pathology of diverse degenerative diseases (Parkinson's disease, Alzheimer's disease and arthritis). Given the known limitations in Western medicine to treat a broad range of inflammatory related illness as well as the emergence of antibiotic resistance, there is a renewed interest in complementary and alternative medicines (CAMs) to achieve these means...
November 15, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27834493/an-emerging-trend-in-functional-foods-for-the-prevention-of-cardiovascular-disease-and-diabetes-marine-algal-polyphenols
#9
Margaret Murray, Aimee L Dordevic, Lisa Ryan, Maxine P Bonham
Marine macroalgae are gaining recognition among the scientific community as a significant source of functional food ingredients. Due to the harsh environments in which macroalgae survive, they produce unique bioactive compounds that are not found in terrestrial plants. Polyphenols are the predominant bioactive compound in brown algae and are accountable for the majority of its biological activity. Phlorotannins are a type of polyphenol that are unique to marine sources and have exhibited protective effects against hyperglycaemia, hyperlipidaemia, inflammation and oxidative stress, known risk factors for cardiovascular disease and diabetic complications, in cell culture, animal studies and some human studies...
November 11, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27833747/microbiota-host-interplay-at-the-gut-epithelial-level-health-and-nutrition
#10
REVIEW
Jean-Paul Lallès
Growing evidence suggests the implication of the gut microbiota in various facets of health and disease. In this review, the focus is put on microbiota-host molecular cross-talk at the gut epithelial level with special emphasis on two defense systems: intestinal alkaline phosphatase (IAP) and inducible heat shock proteins (iHSPs). Both IAP and iHSPs are induced by various microbial structural components (e.g. lipopolysaccharide, flagellin, CpG DNA motifs), metabolites (e.g. n-butyrate) or secreted signal molecules (e...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27829582/postprandial-hyperlipidemia-and-remnant-lipoproteins
#11
Daisaku Masuda, Shizuya Yamashita
Fasting hypertriglyceridemia is positively associated with the morbidity of coronary heart disease (CHD), and postprandial (non-fasting) hypertriglyceridemia is also correlated with the risk status for CHD, which is related to the increase in chylomicron (CM) remnant lipoproteins produced from the intestine. CM remnant particles, as well as oxidized low density lipoprotein (LDL) or very low density lipoprotein (VLDL) remnants, are highly atherogenic and act by enhancing systemic inflammation, platelet activation, coagulation, thrombus formation, and macrophage foam cell formation...
November 8, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27822323/inhibitory-effect-of-actinidia-arguta-on-mutagenesis-inflammation-and-two-stage-mouse-skin-tumorigenesis
#12
Mari Nishimura, Yuma Okimasu, Naoko Miyake, Misako Tada, Ryoko Hida, Tomoe Negishi, Sakae Arimoto-Kobayashi
BACKGROUND: Actinidia arguta, known as sarunashi in Japan, is a vine tree native to east-Asia, including Japan, that produces small fruit rich in anthocyanins, catechins, vitamin C, chlorophyll, beta-carotene and other polyphenols. RESULTS: Our study revealed the inhibitory effect of the juice of A. arguta (arguta-juice) toward the mutagenicity of food-derived carcinogens and polycyclic aromatic hydrocarbons using the Ames test, and antioxidant activity of arguta-juice as determined using a free radical scavenging assay...
2016: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/27822171/grape-seed-powder-improves-renal-failure-of-chronic-kidney-disease-patients
#13
Khaoula Turki, Kamel Charradi, Habib Boukhalfa, Monia Belhaj, Ferid Limam, Ezzedine Aouani
Chronic kidney disease (CKD) is a syndrome characterized by progressive and irreversible deterioration of renal function linked to slow destruction of renal parenchyma, eventually terminating in death when sufficient number of nephrons are damaged. Oxidative stress is commonly observed in CKD patients resulting from an imbalance between overproduction of reactive oxygen species (ROS) and impairment of defence mechanisms. Grape seed extract (GSE) is a polyphenolic mixture exhibiting antioxidant and anti-inflammatory properties...
2016: EXCLI journal
https://www.readbyqxmd.com/read/27818126/anti-inflammatory-protection-afforded-by-cyanidin-3-glucoside-and-resveratrol-in-human-intestinal-cells-via-nrf2-and-ppar-%C3%AE-comparison-with-5-aminosalicylic-acid
#14
Diana Serra, Leonor M Almeida, Teresa C P Dinis
This study investigated the involvement of nuclear factor erythroid 2 (Nrf2) and peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathways in the protection afforded by two polyphenols abundant in diet, cyanidin-3-glucoside and resveratrol, against cytokine-induced inflammation and oxidative insult in HT-29 intestinal cells, in comparison with the drug 5-aminosalicylic acid (5-ASA). Our data show for the first time that in cytokine-challenged cells, cyanidin-3-glucoside and resveratrol induced Nrf2 activation, increased hemoxygenase-1 and glutamate cysteine ligase mRNA expression, enhanced reduced glutathione to oxidized glutathione ratio and inhibited reactive species production, at much lower concentrations than 5-ASA...
November 3, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27809221/tea-polysaccharides-and-their-bioactivities
#15
REVIEW
Ling-Ling Du, Qiu-Yue Fu, Li-Ping Xiang, Xin-Qiang Zheng, Jian-Liang Lu, Jian-Hui Ye, Qing-Sheng Li, Curt Anthony Polito, Yue-Rong Liang
Tea (Camellia sinensis) is a beverage beneficial to health and is also a source for extracting bioactive components such as theanine, tea polyphenols (TPP) and tea polysaccharides (TPS). TPS is a group of heteropolysaccharides bound with proteins. There is evidence showing that TPS not only improves immunity but also has various bioactivities, such as antioxidant, antitumor, antihyperglycemia, and anti-inflammation. However, inconsistent results concerning chemical composition and bioactivity of TPS have been published in recent years...
October 30, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27807255/epigallocatechin-3-gallate-protects-against-hepatic-ischaemia-reperfusion-injury-by-reducing-oxidative-stress-and-apoptotic-cell-death
#16
Eunyoung Tak, Gil-Chun Park, Seok-Hwan Kim, Dae Young Jun, Jooyoung Lee, Shin Hwang, Gi-Won Song, Sung-Gyu Lee
OBJECTIVE: To investigate the protective effects of epigallocatechin-3-gallate (EGCG), a major polyphenol source in green tea, against hepatic ischaemia-reperfusion injury in mice. METHODS: The partial hepatic ischaemia-reperfusion injury model was created by employing the hanging-weight method in C57BL/6 male mice. EGCG (50 mg/kg) was administered via an intraperitoneal injection 45 min before performing the reperfusion. A number of markers of inflammation, oxidative stress, apoptosis and liver injury were measured after the ischaemia-reperfusion injury had been induced...
November 1, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27797683/short-term-effects-of-green-tea-on-blood-pressure-endothelial-function-and-metabolic-profile-in-obese-prehypertensive-women-a-crossover-randomized-clinical-trial
#17
Lívia de P Nogueira, José Firmino Nogueira Neto, Márcia R S T Klein, Antonio F Sanjuliani
BACKGROUND: Green tea consumption has been inversely associated with cardiovascular disease (CVD) in epidemiological studies. Although some interventional trials suggest that green tea has beneficial effects on CVD risk factors, such as hypertension and obesity, others have failed to show such benefits. AIMS: To evaluate the short-term effects of green tea on blood pressure, endothelial function, metabolic profile, and inflammatory activity in obese prehypertensive women...
October 31, 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27794191/modulation-of-iron-transport-metabolism-and-reactive-oxygen-status-by-quercetin-iron-complexes-in-vitro
#18
Richard D Horniblow, Daisy Henesy, Tariq H Iqbal, Chris Tselepis
SCOPE: Excess free-iron is detrimental to health through its ability to participate in free radical generation and amplification of oncogenic pathways. The study aims were to identify polyphenols with iron-chelating potential. METHODS AND RESULTS: Of four polyphenols tested quercetin demonstrated potent iron binding with the physiological outcome dictated by the location of interaction. In the presence of extracellular iron and quercetin, ferritin expression and cellular iron concentrations decreased suggesting the resulting quercetin-iron complex is not internalised...
October 29, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27794174/polyphenol-rich-virgin-olive-oil-reduces-insulin-resistance-and-liver-inflammation-and-improves-mitochondrial-dysfunction-in-high-fat-diet-fed-rats
#19
Adriano Lama, Claudio Pirozzi, Maria Pia Mollica, Giovanna Trinchese, Francesca Di Guida, Gina Cavaliere, Antonio Calignano, Giuseppina Mattace Raso, Roberto Berni Canani, Rosaria Meli
SCOPE: Virgin olive oil is an essential component of the Mediterranean diet. Its anti-oxidant and anti-inflammatory properties are mainly linked to phenolic contents. This study aims to evaluate the beneficial effects of a polyphenol-rich virgin olive oil (HPCOO) or olive oil without polyphenols (WPOO) in rats fed high-fat diet (HFD). METHODS AND RESULTS: Male Sprague-Dawley rats were divided into 4 groups based on the different types of diet: 1) Standard diet (STD); 2) HFD; 3) HFD containing WPOO and 4) HFD containing HPCOO...
October 29, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27792335/oral-administration-of-apple-procyanidins-ameliorates-insulin-resistance-via-suppression-of-pro-inflammatory-cytokines-expression-in-liver-of-diabetic-ob-ob-mice
#20
Kasane Ogura, Masahito Ogura, Toshihiko Shoji, Yuichi Sato, Yumiko Tahara, Gen Yamano, Hiroki Sato, Kazu Sugizaki, Naotaka Fujita, Hisato Tatsuoka, Ryota Usui, Eri Mukai, Shimpei Fujimoto, Nobuya Inagaki, Kazuaki Nagashima
Procyanidins, the main ingredient of apple polyphenols, are known to possess anti-oxidative and anti-inflammatory effects associated closely with the pathophysiology of insulin resistance and type 2 diabetes. We investigated the effects of orally administered apple procyanidins (APCs) on glucose metabolism using diabetic ob/ob mice. We found no difference in body weight or body composition between APCs-treated and untreated mice. 4-week oral administration of APCs ameliorated glucose tolerance, insulin resistance, and hepatic gluconeogenesis in ob/ob mice...
October 28, 2016: Journal of Agricultural and Food Chemistry
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