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Inflammation polyphenols

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https://www.readbyqxmd.com/read/29777940/curcumin-attenuates-cerebral-ischemia-injury-in-sprague-dawley-rats-and-pc12-cells-by-suppressing-overactivated-autophagy
#1
Yan Zhang, Ming Fang, Yameng Sun, Ting Zhang, Nan Shi, Jinfeng Li, Lei Jin, Kangyong Liu, Jianliang Fu
The present study assessed whether the protective effects of curcumin against cerebral ischemia injury were due to the suppression of overactivated autophagy. Curcumin is a well-known natural polyphenolic compound that effectively counteracts oxidation, inflammation, and various types of cancer. Several studies have demonstrated the protective effects of curcumin against ischemia-reperfusion injury in tissues from the lungs, cardiomyocytes, and liver. The present study employed brain injury models induced by middle cerebral artery occlusion (MCAO) in rats and PC12 oxygen-glucose-deprived (OGD) cells...
May 7, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29766292/gut-derived-lipopolysaccharides-increase-post-prandial-oxidative-stress-via-nox2-activation-in-patients-with-impaired-fasting-glucose-tolerance-effect-of-extra-virgin-olive-oil
#2
Roberto Carnevale, Daniele Pastori, Cristina Nocella, Vittoria Cammisotto, Simona Bartimoccia, Marta Novo, Maria Del Ben, Alessio Farcomeni, Francesco Angelico, Francesco Violi
PURPOSE: Post-prandial phase is characterized by enhanced oxidative stress but the underlying mechanism is unclear. We investigated if gut-derived lipopolysaccharide (LPS) is implicated in this phenomenon and the effect of extra virgin olive oil (EVOO) in patients with impaired fasting glucose (IFG). METHODS: This is a randomized cross-over interventional study including 30 IFG patients, to receive a lunch with or without 10 g of EVOO. Serum LPS, Apo-B48, markers of oxidative stress such as oxidized LDL (oxLDL) and soluble Nox2-derived peptide (sNox2-dp), a marker of nicotinamide-adenine-dinucleotide-phosphate oxidase isoform Nox2 activation, and plasma polyphenols were determined before, 60 and 120 min after lunch...
May 16, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29755350/extracts-from-hypericum-hircinum-subsp-majus-exert-antifungal-activity-against-a-panel-of-sensitive-and-drug-resistant-clinical-strains
#3
Noemi Tocci, Daniele Perenzoni, Duilio Iamonico, Francesca Fava, Tobias Weil, Fulvio Mattivi
During the last two decades incidences of fungal infections dramatically increased and the often accompanying failure of available antifungal therapies represents a substantial clinical problem. The urgent need for novel antimycotics called particular attention to the study of natural products. The genus Hypericum includes many species that are used in the traditional medicine to treat pathological states like inflammations and infections caused by fungi. However, despite the diffused use of Hypericum -based products the antifungal potential of the genus is still poorly investigated...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29753753/dietary-polyphenols-and-neurogenesis-molecular-interactions-and-implication-for-brain-ageing-and-cognition
#4
REVIEW
F Sarubbo, D Moranta, G Pani
The increased number of elderly people worldwide poses a major medical and socio-economic challenge: the search of strategies to combat the consequences of the aging process. Oxidative stress and inflammation have been pointed out as the leading causes of brain aging, which in turn alters the functionality of brain. In this context, decline in adult neurogenesis (AN), due to modifications in the neural progenitor stem cells (NSCs) and their microenvironment, is among the aging alterations contributing to cognitive decline...
May 10, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29750172/proanthocyanidins-against-oxidative-stress-from-molecular-mechanisms-to-clinical-applications
#5
REVIEW
Lingyu Yang, Dehai Xian, Xia Xiong, Rui Lai, Jing Song, Jianqiao Zhong
Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerous in vitro and in vivo studies have demonstrated myriad effects potentially beneficial to human health, such as antioxidation, anti-inflammation, immunomodulation, DNA repair, and antitumor activity. Accumulation of prooxidants such as reactive oxygen species (ROS) exceeding cellular antioxidant capacity results in oxidative stress (OS), which can damage macromolecules (DNA, lipids, and proteins), organelles (membranes and mitochondria), and whole tissues...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29747118/hydroxytyrosol-ameliorates-insulin-resistance-by-modulating-endoplasmic-reticulum-stress-and-prevents-hepatic-steatosis-in-diet-induced-obesity-mice
#6
Ningning Wang, Yang Liu, Yanan Ma, Deliang Wen
Endoplasmic reticulum (ER) is a principal organelle responsible for energy and nutrient management. Its dysfunction has been viewed in the context of obesity and related glucolipid metabolic disorders. However, therapeutic approaches to improve ER adaptation and systemic energy balance in obesity are limited. Thus, we examined whether hydroxytyrosol (HT), an important polyphenolic compound found in virgin olive oil, could correct the metabolic impairments in diet-induced obesity (DIO) mice. Here, we found that HT gavage for 10 weeks significantly ameliorated glucose homeostasis and chronic inflammation and decreased hepatic steatosis in DIO mice...
April 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29743826/effect-of-bilberry-juice-on-indices-of-muscle-damage-and-inflammation-in-runners-completing-a-half-marathon-a-randomised-placebo-controlled-trial
#7
Anthony Lynn, Samantha Garner, Nichola Nelson, Trevor N Simper, Anna C Hall, Mayur K Ranchordas
Background: Emerging evidence indicates that fruits rich in polyphenols may attenuate exercise-induced muscle damage and associated markers of inflammation and soreness. This study was conducted to determine whether bilberry juice (BJ), which is particularly rich in polyphenols, reduces markers of muscle damage in runners completing a half marathon. Methods: A total of 21 recreationally trained runners (age 30.9 ± 10.4 y; mass 71.6 ± 11.0 kg; M = 16; F = 5) were recruited to a single blind, randomised, placebo-controlled, parallel study...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29742452/anti-senescence-compounds-a-potential-nutraceutical-approach-to-healthy-aging
#8
REVIEW
Felicia Gurău, Simone Baldoni, Francesco Prattichizzo, Emma Espinosa, Francesco Amenta, Antonio Domenico Procopio, Maria Cristina Albertini, Massimiliano Bonafè, Fabiola Olivieri
The desire of eternal youth seems to be as old as mankind. However, the increasing life expectancy experienced by populations in developed countries also involves a significantly increased incidence of the most common age-related diseases (ARDs). Senescent cells (SCs) have been identified as culprits of organismal aging. Their number rises with age and their senescence-associated secretory phenotype fuels the chronic, pro-inflammatory systemic state (inflammaging) that characterizes aging, impairing the regenerative ability of stem cells and increasing the risk of developing ARDs...
May 6, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29740000/ameliorative-potential-of-desalted-salicornia-europaea-l-extract-in-multifaceted-alzheimer-s-like-scopolamine-induced-amnesic-mice-model
#9
Govindarajan Karthivashan, Shin-Young Park, Mee-Hyang Kweon, Joonsoo Kim, Md Ezazul Haque, Duk-Yeon Cho, In-Su Kim, Eun-Ah Cho, Palanivel Ganesan, Dong-Kug Choi
The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and chromatographic profiling of desalted and enzyme-digested SE ethanol extract (SE-EE). Subsequently, we evaluated the anti-neuroinflammatory and ameliorative potential of SE-EE in LPS-inflicted BV-2 microglial cells and scopolamine-induced amnesic C57/BL6N mice, respectively...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736620/cardioprotective-effect-of-zingerone-against-oxidative-stress-inflammation-and-apoptosis-induced-by-cisplatin-or-gamma-radiation-in-rats
#10
Ahmed F Soliman, Lobna M Anees, Doaa M Ibrahim
Despite their clinical benefits in cancer treatment, the deleterious effects on heart following chemo/radiotherapy are of increasing importance. Zingerone, a natural polyphenol, possesses multiple biological activities, such as antioxidant and anti-inflammatory. Thus, the current study was designed to assess the potential cardioprotective effects of zingerone against cisplatin or γ-radiation. Zingerone was given by intragastric intubation (25 mg/kg) daily for three successive weeks prior to the induction of cardiotoxicity using a single dose of cisplatin (20 mg/kg, i...
May 7, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29734116/polyphenol-rich-green-tea-extract-improves-adipose-tissue-metabolism-by-down-regulating-mir-335-expression-and-mitigating-insulin-resistance-and-inflammation
#11
Rosemari Otton, Anaysa Paola Bolin, Leticia Torres Ferreira, Marcelo Paradiso Marinovic, Andrea Livia Silva Rocha, Marcelo Alves Mori
Obesity leads to changes in miRNA expression in adipose tissue, and this modulation is linked to the pathophysiology of the disease. Green tea (GT) is a natural source of polyphenols that have been shown to confer health benefits, particularly preventing metabolic diseases. Here, we investigated if the beneficial effects of GT in obesity results from changes in the miRNA profile in white adipose tissue. GT treatment [500 mg/body weight (BW)/12 weeks] increased energy expenditure of high-fat diet-fed mice (16 weeks), leading to reduced weight gain, decreased adiposity, reduced inflammation and improved insulin sensitivity...
April 7, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29733520/mango-mangifera-indica-l-polyphenols-ameliorate-functional-constipation-symptoms-in-humans-beyond-equivalent-amount-of-fiber
#12
Vinicius P Venancio, Hyemee Kim, Maritza A Sirven, Carmen D Tekwe, Gilson Honvoh, Stephen T Talcott, Susanne U Mertens-Talcott
SCOPE: Chronic constipation is a common gastrointestinal condition associated with intestinal inflammation and considerably impaired quality of life, affecting about 20% of Americans. Dietary fiber and laxatives aid in its treatment but do not fully address all symptoms, such as intestinal inflammation. Mango (Mangifera indica L.), a fiber- and polyphenol-rich fruit may provide anti-inflammatory effects in constipation. METHODS AND RESULTS: The 4-week consumption of mango fruit (300 g) or the equivalent amount of fiber was investigated in otherwise healthy human volunteers with chronic constipation that were randomly assigned to either group...
May 7, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29729252/pre-and-post-treatment-with-curcumin-and-resveratrol-protects-astrocytes-after-oxidative-stress
#13
Amita Daverey, Sandeep K Agrawal
The two most studied polyphenolic compounds, curcumin (Cur) and resveratrol (Res), have been reported to protect oxidative damage of astrocytes. The present study is designed to examine the comparative anti-oxidative effect of Cur and Res on astrocytes by studying their potential to protect H2 O2 induced oxidative stress at 4h and 24h time exposure. The effect of Cur and Res on cell viability, ROS production, inflammation and astrogliosis was compared. The effect of these two on Nrf2 expression and its translocation to nuclear compartment was investigated...
May 2, 2018: Brain Research
https://www.readbyqxmd.com/read/29726680/natural-stilbenoids-have-anti-inflammatory-properties-in-vivo-and-down-regulate-the-production-of-inflammatory-mediators-no-il6-and-mcp1-possibly-in-a-pi3k-akt-dependent-manner
#14
Heikki Eräsalo, Mari Hämäläinen, Tiina Leppänen, Ilari Mäki-Opas, Mirka Laavola, Raisa Haavikko, Jari Yli-Kauhaluoma, Eeva Moilanen
Stilbenoids are a group of polyphenolic compounds found in plants, trees, berries, and nuts. Stilbenoids have been shown to serve an antimicrobial and antifungal function in plants. There is also evidence that as a part of the human diet, stilbenoids play an important role as antioxidants and may have anti-inflammatory effects. The PI3K/Akt pathway is a well-characterized signaling pathway controlling cellular functions involved in growth and cell cycle and in metabolism. There is also increasing evidence to show the involvement of this pathway in the regulation of inflammatory responses...
May 4, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29724195/bioactive-components-and-mechanisms-of-chinese-poplar-propolis-alleviates-oxidized-low-density-lipoprotein-induced-endothelial-cells-injury
#15
Huasong Chang, Wenwen Yuan, Haizhu Wu, Xusheng Yin, Hongzhuan Xuan
BACKGROUND: Propolis, a polyphenol-rich natural product, has been used as a functional food in anti-inflammation. However, its bioactive components and mechanisms have not been fully elucidated. To discover the bioactive components and anti-inflammatory mechanism, we prepared and separated 8 subfractions from ethyl acetate extract of Chinese propolis (EACP) and investigated the mechanism in oxidized low density lipoprotein (ox-LDL) induced human umbilical vein endothelial cells (HUVECs) damage...
May 3, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29722833/an-18-mo-randomized-double-blind-placebo-controlled-trial-of-dha-rich-fish-oil-to-prevent-age-related-cognitive-decline-in-cognitively-normal-older-adults
#16
Vanessa Danthiir, Diane E Hosking, Ted Nettelbeck, Andrew D Vincent, Carlene Wilson, Nathan O'Callaghan, Eva Calvaresi, Peter Clifton, Gary A Wittert
Background: Fish oil trials in cognitively healthy older adults have yielded inconsistent results. Supplementation may differentially affect the domains that underpin cognitive performance, and effects may differ across sex or genotype. Objective: The aim of this study was to test whether docosahexaenoic acid (DHA)-rich fish oil slows 18-mo cognitive decline in cognitively healthy elders. Design: In a double-blind, randomized, placebo-controlled, parallel-group trial, cognitively healthy Australian community-dwelling adults (aged 65-90 y) consumed either 1720 mg DHA and 600 mg eicosapentaenoic acid or low-polyphenolic olive oil daily, as capsules, for 18 mo...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29721509/anthocyanins-function-as-anti-inflammatory-agents-in-a-drosophila-model-for-adipose-tissue-macrophage-infiltration
#17
Alice Valenza, Carola Bonfanti, Maria Enrica Pasini, Paola Bellosta
Epidemiological and preclinical studies have demonstrated that bioactive foods like flavonoids, polyphenolic compounds derived from fruits and vegetables, exert a protective action against obesity, cardiovascular disorders, and Adipocyte Tissue Macrophage infiltration (ATM). All these pathologies are characterized by increase in reactive oxygen species (ROS) and in proinflammatory cytokines that have been shown to favor the migration of immune cells, particularly of macrophages, in metabolically active organs like the liver and adipose tissue, that in Drosophila are constituted by a unique organ: the fat body...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29719628/novel-water-soluble-lignin-derivative-bp-cx-1-identification-of-components-and-screening-of-potential-targets-in-silico-and-in-vitro
#18
Elena I Fedoros, Alexey A Orlov, Alexander Zherebker, Ekaterina A Gubareva, Mikhail A Maydin, Andrey I Konstantinov, Konstantin A Krasnov, Ruben N Karapetian, Ekaterina I Izotova, Sergey E Pigarev, Andrey V Panchenko, Margarita L Tyndyk, Dmitry I Osolodkin, Evgeny N Nikolaev, Irina V Perminova, Vladimir N Anisimov
Identification of molecular targets and mechanism of action is always a challenge, in particular - for natural compounds due to inherent chemical complexity. BP-Cx-1 is a water-soluble modification of hydrolyzed lignin used as the platform for a portfolio of innovative pharmacological products aimed for therapy and supportive care of oncological patients. The present study describes a new approach, which combines in vitro screening of potential molecular targets for BP-Cx-1 using Diversity Profile - P9 panel by Eurofins Cerep (France) with a search of possible active components in silico in ChEMBL - manually curated chemical database of bioactive molecules with drug-like properties...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29714395/cocoa-procyanidins-modulate-transcriptional-pathways-linked-to-inflammation-and-metabolism-in-human-dendritic-cells
#19
Helene L E Midttun, Aina Ramsay, Irene Mueller-Harvey, Andrew R Williams
Foods rich in polyphenols such as procyanidins (PC) have been proposed to have anti-inflammatory properties, and we have previously reported inhibition of lipopolysaccharide (LPS)-induced inflammatory cytokine secretion in human dendritic cells (DCs) by PC derived from cocoa. To explore the mechanistic basis of this inhibition, here we conducted transcriptomic analysis on DCs cultured with either LPS or LPS combined with oligomeric cocoa PC. Procyanidins suppressed a number of genes encoding cytokines and chemokines such as CXCL1, but also genes involved in the cGMP pathway such as GUCY1A3 (encoding guanylate cyclase soluble subunit alpha-3)...
May 1, 2018: Food & Function
https://www.readbyqxmd.com/read/29714150/cinnamon-polyphenol-extract-exerts-neuroprotective-activity-in-traumatic-brain-injury-through-modulation-of-nfr2-and-cytokine-expression
#20
Burak Yulug, Ertugrul Kilic, Serdar Altunay, Cenk Ersavas, Cemal Orhan, Arman Dalay, Nurhan Sahin, Mehmet Tuzcu, Vijaya Juturu, Kazim Sahin
INTRODUCTION: Cinnamon cinnamon polyphenol extract is a traditional spice commonly used in different areas of the world for treatment of different disease conditions which are associated with inflammation and oxidative stress. Despite many preclinical studies showing the anti-oxidative, anti-inflammatory effects of CN, the underlying mechanisms in signaling pathways via which cinnamon protects the brain after brain trauma remained largely unknown. However, there is still no preclinical study delineating the possible molecular mechanism of neuroprotective effects cinnamon polyphenol extractin TBI...
April 30, 2018: CNS & Neurological Disorders Drug Targets
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