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Inflammation polyphenols

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https://www.readbyqxmd.com/read/28427563/neuroinflammation-in-alzheimer-s-disease-the-preventive-and-therapeutic-potential-of-polyphenolic-nutraceuticals
#1
Yousef Sawikr, Nagendra Sastry Yarla, Ilaria Peluso, Mohammad Amjad Kamal, Gjumrakch Aliev, Anupam Bishayee
Brain inflammation, characterized by increased microglia and astrocyte activation, increases during aging and is a key feature of neurodegenerative diseases, such as Alzheimer's disease (AD). In AD, neuronal death and synaptic impairment, induced by amyloid-β (Aβ) peptide, are at least in part mediated by microglia and astrocyte activation. Glial activation results in the sustained production of proinflammatory cytokines and reactive oxygen species, giving rise to a chronic inflammatory process. Astrocytes are the most abundant glial cells in the central nervous system and are involved in the neuroinflammation...
2017: Advances in Protein Chemistry and Structural Biology
https://www.readbyqxmd.com/read/28425868/pomegranate-as-a-possible-treatment-in-reducing-risk-of-developing-wound-healing-obesity-neurodegenerative-disorders-and-diabetes-mellitus
#2
Manaf AlMatar, Md Rashedul Islam, Othman Albari, Işıl Var, Fatih Köksal
Four distinguished although overlying stages make up the methodical procedure of wound healing, which are hemostasis, inflammation, proliferation and remodelling. Multiple sclerosis (MS) comprises a persistent inflammatory infection of the central nervous system, and is related to demyelination, neurodegeneration, as well as susceptibility to oxidative pressure. Obesity signifies a swiftly developing danger to the wellbeing of populations in a rising number of nations. Usually called diabetes mellitus (DM) by medical practitioners, diabetes details a collection of metabolic diseases within which the individual has raised blood glucose, either due to an insufficiency of insulin generation, or the lack of suitable response by the body to insulin, or both...
April 19, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28419855/a-randomized-trial-of-silymarin-for-the-treatment-of-non-alcoholic-steatohepatitis
#3
Wah-Kheong Chan, Nik Raihan Nik Mustapha, Sanjiv Mahadeva
BACKGROUND & AIMS: Silymarin is a complex mixture of 6 major flavonolignans and other minor polyphenolic compounds derived from the milk thistle plant Silybum marianum; it has shown anti-oxidant, anti-inflammatory and anti-fibrotic effects, and may be useful in patients with non-alcoholic fatty liver disease (NAFLD). We aimed to study the efficacy of silymarin in patients with non-alcoholic steatohepatitis (NASH)-the more severe form of NAFLD. METHODS: We performed a randomized, double-blind, placebo-controlled trial of consecutive adults with biopsy-proven NASH and a NAFLD activity score (NAS) of 4 or more at a tertiary care hospital in Kuala Lumpur, Malaysia, from November 2012 through August 2014...
April 15, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28416441/glechoma-hederacea-extracts-attenuate-cholestatic-liver-injury-in-a-bile-duct-ligated-rat-model
#4
Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Su-Lan Liao, Chih-Cheng Wu, Pin-Ho Pan, Su-Tze Chou, Chun-Jung Chen
ETHNOPHARMACOLOGICAL RELEVANCE: In traditional Chinese medicine, Glechoma hederacea is frequently prescribed to patients with cholelithiasis, dropsy, abscess, diabetes, inflammation, and jaundice. Polyphenolic compounds are main bioactive components of Glechoma hederacea. AIM OF THE STUDY: This study was aimed to investigate the hepatoprotective potential of hot water extract of Glechoma hederacea against cholestatic liver injury in rats. MATERIALS AND METHODS: Cholestatic liver injury was produced by ligating common bile ducts in Sprague-Dawley rats...
April 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28408067/polyphenol-supplementation-inhibits-physiological-increase-of-prostaglandin-e2-during-reproductive-period-a-randomized-clinical-trial
#5
A M Zilio, P Zielinsky, I Vian, K Lampert, D Raupp, C Weschenfelder, C Brum, A Arnt, A Piccoli, L H Nicoloso, M I Schaun, M Markoski
Anti-inflammatory property of polyphenols and their effect on the metabolism of prostaglandins is not established in healthy humans. This study aimed to evaluate the effect of polyphenol supplementation in plasma levels of prostaglandin E2 and other markers of inflammation and oxidative stress in women using contraceptives. In this randomized double-blind clinical trial, women aged 25-35 years were selected. Participants received capsules containing polyphenols or placebo, to be consumed for fifteen days. From 40 women randomized, 28 completed the study...
April 5, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28402903/nutritional-anti-inflammatories-in-the-treatment-and-prevention-of-type-2-diabetes-mellitus-and-the-metabolic-syndrome
#6
REVIEW
Lea Merone, Robyn McDermott
AIMS: Obesity-fuelled metabolic syndrome and diabetes is now a global epidemic. There is increasing evidence that these and other chronic conditions have common inflammatory antecedents. There is an interest in nutritionally based anti-inflammatory treatments for type 2 diabetes and metabolic syndrome. The aim of this review is to examine the evidence from a 5-year period; 2011-2016, for nutritionally based anti-inflammatory treatments for the Metabolic Syndrome and Type 2 Diabetes Mellitus...
February 20, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28397013/modulatory-efficacy-of-dieckol-on-xenobiotic-metabolizing-enzymes-cell-proliferation-apoptosis-invasion-and-angiogenesis-during-ndea-induced-rat-hepatocarcinogenesis
#7
Velayutham Sadeeshkumar, Arul Duraikannu, Samuthrapandian Ravichandran, Paulrasu Kodisundaram, Wilson Sylvester Fredrick, Rajagopal Gobalakrishnan
Dieckol (DEK) is a major polyphenol of marine brown seaweed Ecklonia cava which is a potential candidate for cancer therapy. However, the underlying mechanism of DEK as an anticancer drug remains to be elucidated. In this study, we evaluated the molecular mechanisms involved in the chemopreventive efficacy of DEK in N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis rats by analyzing markers of xenobiotic-metabolizing enzymes (XMEs), apoptosis, invasion, and angiogenesis. Rats administered NDEA developed hepatocarcinogenesis that displayed apoptosis avoidance coupled to upregulation of pro-inflammatory, invasion, and angiogenesis markers...
April 10, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28396714/cinnamon-polyphenol-extract-inhibits-hyperlipidemia-and-inflammation-by-modulation-of-transcription-factors-in-high-fat-diet-fed-rats
#8
Zeynep Tuzcu, Cemal Orhan, Nurhan Sahin, Vijaya Juturu, Kazim Sahin
We evaluated the effects of cinnamon polyphenol extract on hepatic transcription factors expressions including SREBP-1c and LXR-α in rats fed high fat diet (HFD). Twenty-eight Wistar rats were allocated into four groups: (i) normal control: animals fed with normal chow; (ii) cinnamon: animals supplemented with cinnamon polyphenol; (iii) HFD: animals fed a high-fat diet; and (iv) HFD + cinnamon: animals fed a high-fat diet and treated with cinnamon polyphenol. Obesity was linked to hyperglycemia, hyperlipidemia, and oxidative stress as imitated by elevated serum glucose, lipid profile, and serum and liver malondialdehyde (MDA) concentrations...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28393456/blackcurrant-anthocyanins-modulate-ccl11-secretion-and-suppress-allergic-airway-inflammation
#9
Odette M Shaw, Tafadzwa Nyanhanda, Tony K McGhie, Jacquie L Harper, Roger D Hurst
CCL11, a chemokine, is linked to the early development of airways eosinophilia in allergic asthma. Therefore, CCL11 production is a target for abrogating eosinophilic-driven airway inflammation. Blackcurrants are high in compounds that regulate inflammation, particularly anthocyanins. In this study we investigated the effect of oral blackcurrant supplementation on allergen-induced eosinophilia and CCL11 production; we also profiled key compounds in blackcurrants that were linked to this effect. 10 mg/kg (total anthocyanins) of a commercially available, anthocyanin-rich New Zealand 'Ben Ard' blackcurrant extract ('Currantex 30') attenuated ovalbumin-induced inflammation, eosinophilia (by 52...
April 9, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28387707/alleviation-of-ultraviolet-b-induced-photodamage-by-coffea-arabica-extract-in-human-skin-fibroblasts-and-hairless-mouse-skin
#10
Po-Yuan Wu, Chi-Chang Huang, Yin Chu, Ya-Han Huang, Ping Lin, Yu-Han Liu, Kuo-Ching Wen, Chien-Yih Lin, Mei-Chich Hsu, Hsiu-Mei Chiang
Coffea arabica extract (CAE) containing 48.3 ± 0.4 mg/g of chlorogenic acid and a trace amount of caffeic acid was found to alleviate photoaging activity in human skin fibroblasts. In this study, polyphenol-rich CAE was investigated for its antioxidant and antiinflammatory properties, as well as for its capability to alleviate ultraviolet B (UVB)-induced photodamage in BALB/c hairless mice. The results indicated that 500 μg/mL of CAE exhibited a reducing power of 94.7%, ferrous ion chelating activity of 46...
April 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28387565/the-therapeutic-potential-of-piceatannol-a-natural-stilbene-in-metabolic-diseases-a-review
#11
Jonathan Kershaw, Kee-Hong Kim
Metabolic disease comprises a set of risk factors highly associated with obesity and insulin resistance and is a consequence of central adiposity, hyperglycemia, and dyslipidemia. Furthermore, obesity increases the risk of the development of metabolic disease due to ectopic fat deposition, low-grade inflammation, and systemic energy disorders caused by dysregulated adipose tissue function. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and has been reported to exhibit anticancer and anti-inflammatory properties...
April 7, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28386616/molecular-adaptations-underlying-the-beneficial-effects-of-hydroxytyrosol-in-the-pathogenic-alterations-induced-by-a-high-fat-diet-in-mouse-liver-ppar-%C3%AE-and-nrf2-activation-and-nf-%C3%AE%C2%BAb-down-regulation
#12
Rodrigo Valenzuela, Paola Illesca, Francisca Echeverría, Alejandra Espinosa, Miguel Ángel Rincón-Cervera, Macarena Ortiz, María Catalina Hernandez-Rodas, Alfonso Valenzuela, Luis A Videla
SCOPE: Non-alcoholic fatty liver disease (NAFLD) is a condition characterized by an increment in the liver fat content, with a concomitant reduction in the content of n-3-long chain polyunsaturated fatty acids (n-3 LCPUFAs), downregulation of PPAR-α activity, and upregulation of NF-κB activity, effects that induce pro-lipogenic and pro-inflammatory responses. Hydroxytyrosol (HT), a polyphenol with cytoprotective effects present in extra virgin olive oil, improves the cellular antioxidant capacity for activation of transcription factor Nrf2...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28385617/antioxidant-based-topical-formulations-influence-on-the-inflammatory-response-of-japanese-skin-a-clinical-study-using-non-invasive-techniques
#13
Tais A L Wagemaker, Patrícia M B G Maia Campos, Kenji Shimizu, Daiki Kyotani, Daisuke Yoshida
Cutaneous irritants exposure induces an excess of ROS in the skin and can ensue an inflammatory response. Topical antioxidant-based formulations can help to counteract ROS generation. This study evaluated the influence of antioxidant-based topical formulations on the inflammatory response of skin, using a combination of in vivo real-time non-invasive techniques. Nine test areas were defined on each volar forearm of the 25 Japanese volunteers. Measurements were performed before and after treatment with 15µL of a 5% sodium dodecyl sulfate solution and 15µL of the same based formulation or the vehicle with 1% of the antioxidants...
April 3, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28376392/multi-targeted-protection-of-acetaminophen-induced-hepatotoxicity-in-mice-by-tannic-acid
#14
Jianping Zhang, Qiongtao Song, Xue Han, Yuanyuan Zhang, Ying Zhang, Xuan Zhang, Xi Chu, Fenghua Zhang, Li Chu
Tannic acid (TA) is the polyphenol that has beneficial health effects against oxidative stress. However, the hepatoprotective effects of TA are still relatively unknown. In the present study, we evaluated the effects of TA on an acetaminophen (APAP)-induced hepatotoxicity model, which was established by administration of 400mg/kg of APAP. The levels of alanine transferase (ALT), aspartate transferase (AST), dendothelin-1 (ET-1), nitric oxide (NO) and malondialdehyde (MDA) in the APAP-induced hepatotoxicity mice were significantly increased (up to ~200%), while their levels were reduced by pretreatment with TA (25 and 50mg/kg) (P<0...
April 1, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28373762/traditional-chinese-herbal-extracts-inducing-autophagy-as-a-novel-approach-in-therapy-of-nonalcoholic-fatty-liver-disease
#15
REVIEW
Cong Liu, Jia-Zhi Liao, Pei-Yuan Li
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases around the world due to the modern sedentary and food-abundant lifestyle, which is characterized by excessive fat accumulation in the liver related with causes other than alcohol abuse. It is widely acknowledged that insulin resistance, dysfunctional lipid metabolism, endoplasmic reticulum stress, oxidative stress, inflammation, and apoptosis/necrosis may all contribute to NAFLD. Autophagy is a protective self-digestion of intracellular organelles, including lipid droplets (lipophagy), in response to stress to maintain homeostasis...
March 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28369685/isorhapontigenin-a-bioavailable-dietary-polyphenol-suppresses-airway-epithelial-cell-inflammation-through-a-corticosteroid-independent-mechanism
#16
Samuel Chao Ming Yeo, Peter S Fenwick, Peter J Barnes, Hai Shu Lin, Louise E Donnelly
BACKGROUND AND PURPOSE: Chronic obstructive pulmonary disease (COPD) is a corticosteroid-resistant airway inflammatory condition. Resveratrol has exhibited anti-inflammatory activities in COPD but has weak potency and poor pharmacokinetics. This study aims to evaluate the potential of isorhapontigenin, another dietary polyphenol, as a novel anti-inflammatory agent for COPD by examining its effects in vitro and its pharmacokinetics in vivo. EXPERIMENTAL APPROACH: Primary human airway epithelial cells derived from healthy and COPD subjects and A549 epithelial cells were incubated with isorhapontigenin or resveratrol and stimulated with IL-1β in the presence or absence of cigarette smoke extract...
March 30, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28365685/-epigallocatechin-3-gallate-inhibits-arsenic-induced-inflammation-and-apoptosis-through-suppression-of-oxidative-stress-in-mice
#17
Nan-Hui Yu, Haiping Pei, Yong-Pan Huang, Yu-Fei Li
BACKGROUND/AIMS: Exposure to arsenic in individuals has been found to be associated with various health-related problems including skin lesions, cancer, and cardiovascular and immunological disorders. (-)-Epigallocatechin-3-gallate (EGCG), the main and active polyphenolic catechin present in green tea, has shown potent antioxidant, anti-apoptotic and anti-inflammatory activity in vivo and in vitro. Thus, the present study was conducted to investigate the protective effects of EGCG against arsenic-induced inflammation and immunotoxicity in mice...
April 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28356040/the-relevance-of-dietary-polyphenols-in-cardiovascular-protection
#18
Ana Gabriela Murillo, Maria Luz Fernandez
The chemical structure of polyphenols consisting of aromatic rings, capable of quenching free radicals, makes them ideal candidates to protect against oxidation. Polyphenols are present in a variety of foods including grapes, berries, dark chocolate, coffee and tea to mention a few. A number of studies have shown that dietary polyphenols exert a protective effect against hypertension, dyslipidemias, inflammation, endothelial function and atherosclerosis, conditions associated with increased risk for cardiovascular disease...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28356027/natural-polyphenols-in-the-treatment-of-alzheimer-s-disease
#19
Syed Badrul Syarifah Noratiqah, Isa Naina-Mohamed, Mohamed S Zulfarina, H M S Qodriyah
Neurodegenerative disease is an incurable disease which involves the degeneration or death of the nerve cells. Alzheimer's Disease (AD) is a neurodegenerative disease discovered in 1906 by Alois Alzheimer, a German clinical psychiatrist and neuroanatomist. The main pathological hallmarks of this disease are the formation of extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangle (NFT). The accumulation of the amyloid protein aggregates in the brain of AD patients leads to oxidative stress and inflammation...
March 28, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28350127/resveratrol-inhibits-the-il-1%C3%AE-induced-expression-of-mmp-13-and-il-6-in-human-articular-chondrocytes-via-tlr4-myd88-dependent-and-independent-signaling-cascades
#20
Hailun Gu, Yongliang Jiao, Xiaolu Yu, Xingyao Li, Wei Wang, Lifeng Ding, Li Liu
The natural polyphenolic compound, resveratrol, has been shown to exhibit anti-osteoarthritic activity. Therefore it is hypothesized that resveratrol may serve as a nutritional supplement to counteract osteoarthritis (OA). However, the mechanisms responsible for these anti-osteoarthritic effects have not yet been fully elucidated. The aim of this study was to determine whether the biological effects of resveratrol against interleukin (IL)-1β‑induced inflammation in human articular chondrocytes involved both Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-dependent and -independent signaling pathways...
February 9, 2017: International Journal of Molecular Medicine
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