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Inflammation polyphenols

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https://www.readbyqxmd.com/read/28229451/honokiol-protects-skin-cells-against-inflammation-collagenolysis-apoptosis-and-senescence-caused-by-cigarette-smoke-damage
#1
Adilson Costa, Gustavo Facchini, Ana Lúcia T A Pinheiro, Michelle S da Silva, Michael Y Bonner, Jack Arbiser, Samara Eberlin
BACKGROUND: Pollution, especially cigarette smoke, is a major cause of skin damage. OBJECTIVES: To assess the effects of the small molecule polyphenol, honokiol, on reversing cigarette smoke-induced damage in vitro to relevant skin cells. METHODS: Keratinocytes (HaCat) cultures were exposed to cigarette smoke and, after 48 hours, IL-1α and IL-8 were measured in cell supernatants. Moreover, TIMP-2 production, apoptosis rate, and senescence β-galactosidase expression were evaluated in primary human foreskin fibroblasts (HFF-1) cultures...
February 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28215316/aronia-berry-polyphenol-consumption-reduces-plasma-total-and-low-density-lipoprotein-cholesterol-in-former-smokers-without-lowering-biomarkers-of-inflammation-and-oxidative-stress-a-randomized-controlled-trial
#2
Liyang Xie, Terrence Vance, Bohkyung Kim, Sang Gil Lee, Christian Caceres, Ying Wang, Patrice A Hubert, Ji-Young Lee, Ock K Chun, Bradley W Bolling
Former smokers are at increased risk for cardiovascular disease. We hypothesized that dietary aronia polyphenols would reduce biomarkers of cardiovascular disease risk, inflammation, and oxidative stress in former smokers. We also determined the extent these effects were associated with polyphenol bioavailability. A 12-week, randomized, placebo-controlled trial was conducted in 49 healthy adult former smokers (n = 24/placebo, n = 25/aronia) to evaluate if daily consumption of 500 mg aronia extract modulated plasma lipids, blood pressure, biomarkers of inflammation and oxidative stress, and lipid transport genes of peripheral blood mononuclear cells...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28213268/fisetin-inhibits-il-1%C3%AE-induced-inflammatory-response-in-human-osteoarthritis-chondrocytes-through-activating-sirt1-and-attenuates-the-progression-of-osteoarthritis-in-mice
#3
Wenhao Zheng, Zhenhua Feng, Shengban You, Hui Zhang, Zhenyu Tao, Quan Wang, Hua Chen, Yaosen Wu
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Fisetin, a polyphenol extracted from fruits and vegetables, has been reported to have anti-inflammatory effects. Our study aimed to investigate the effect of fisetin on OA both in vitro and in vivo. In vitro, chondrocytes were pretreated with fisetin alone or fisetin combined with sirtinol (an inhibitor of SIRT1) for 2h before IL-1β stimulation. Production of NO, PGE2, TNF-α and IL-6 were evaluated by the Griess reaction and ELISAs...
February 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28212342/a-review-on-the-phytochemistry-pharmacology-and-pharmacokinetics-of-amentoflavone-a-naturally-occurring-biflavonoid
#4
REVIEW
Sheng Yu, Hui Yan, Li Zhang, Mingqiu Shan, Peidong Chen, Anwei Ding, Sam Fong Yau Li
Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families...
February 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28204817/resveratrol-inhibits-the-il-1%C3%AE-induced-expression-of-mmp-13-and-il-6-in-human-articular-chondrocytes-via-tlr4-myd88-dependent-and-independent-signaling-cascades
#5
Hailun Gu, Yongliang Jiao, Xiaolu Yu, Xingyao Li, Wei Wang, Lifeng Ding, Li Liu
The natural polyphenolic compound, resveratrol, has been shown to exhibit anti-osteoarthritic activity. Therefore it is hypothesized that resveratrol may serve as a nutritional supplement to counteract osteoarthritis (OA). However, the mechanisms responsible for these anti-osteoarthritic effects have not yet been fully elucidated. The aim of this study was to determine whether the biological effects of resveratrol against interleukin (IL)-1β‑induced inflammation in human articular chondrocytes involved both Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-dependent and -independent signaling pathways...
March 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28197150/curcumin-attenuates-titanium-particle-induced-inflammation-by-regulating-macrophage-polarization-in-vitro-and-in-vivo
#6
Bin Li, Yan Hu, Yaochao Zhao, Mengqi Cheng, Hui Qin, Tao Cheng, Qiaojie Wang, Xiaochun Peng, Xianlong Zhang
Periprosthetic inflammatory osteolysis and subsequent aseptic loosening are commonly observed in total joint arthroplasty. Other than revision surgery, few approved treatments are available for this complication. Wear particle-induced inflammation and macrophage polarization state play critical roles in periprosthetic osteolysis. We investigated the effects of curcumin, a polyphenol extracted from Curcuma longa, on titanium (Ti) particle-induced inflammation and macrophage polarization in vitro using the murine cell line RAW 264...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28192862/long-term-dietary-quercetin-enrichment-as-a-cardioprotective-countermeasure-in-mdx-mice
#7
Christopher Ballmann, Thomas Denney, Ronald J Beyers, Tiffany Quindry, Matthew Romero, Joshua T Selsby, John C Quindry
Duchenne Muscular Dystrophy (DMD) causes declines in cardiac health resulting in premature mortality. As a potential countermeasure, quercetin is a polyphenol possessing inherent anti-inflammatory and antioxidant effects that activate proliferator-activated γ coactivator 1α (PGC-1α) increasing mitochondrial biogenesis protein abundance. We investigated the extent to which lifelong 0.2% dietary quercetin enrichment attenuates dystrophic cardiopathology in mdx mice. Dystrophic animals were fed quercetin or control diet for 12 months while control C57 mice were fed a control diet...
February 13, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28191529/the-green-tea-polyphenol-epigallocatechin-3-gallate-and-its-beneficial-roles-in-chronic-kidney-disease
#8
REVIEW
Hui Bao, Ai Peng
Chronic kidney disease (CKD), a condition that affects around 10% of the population, has become a significant public health concern. Current therapeutic strategies to slow down the progression of CKD remain limited. Thus, it is urgent to develop new strategies to manage the patients with CKD. Work within the past decade has improved our understanding of the mechanisms contributing to CKD. In particular, oxidative stress as well as inflammation appears to play a pivotal role in CKD progression. ()-Epigallocatechin-3-gallate (EGCG), the major catechin of green tea extract, is known as a powerful antioxidant and reactive oxygen species scavenger...
September 1, 2016: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28190391/novel-caffeic-acid-phenethyl-ester-cape-analogues-as-inducers-of-heme-oxygenase-1
#9
Valeria Pittalà, Luca Vanella, Loredana Salerno, Claudia Di Giacomo, Rosaria Acquaviva, Marco Raffaele, Giuseppe Romeo, Maria N Modica, Orazio Prezzavento, Valeria Sorrenti
BACKGROUND: Heme Oxygenase-1 (HO-1) is a metabolic enzyme strongly involved in processes including cytoprotection, modulation of inflammatory response, anti-oxidative functions, regulation of cellular proliferation, angiogenesis, cardiovascular homeostasis, and immuno-modulation. HO-1 induction and/or activation is able to counterbalance, at least in part, oxidative stress and inflammation. For this reason, HO-1 can be regarded as an attractive target to ameliorate different stress-related pathologies...
February 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28183265/some-important-dietary-polyphenolic-compounds-an-anti-inflammatory-and-immunoregulatory-perspective
#10
Mayank Kinger, Sushil Kumar, Vinod Kumar
Inflammation plays an important role in maintaining the body's homeostasis. It repairs the damaged tissues of the body resulting from injury or infection. In addition, a diverse array of diseases like hepatitis, arthritis and colitis has been reported and described to be associated with inflammatory processes. Some autoimmune diseases like inflammatory bowel disease (IBD) emerge by the influence of numerous genes in complex environmental situations belongs to inflammation. The currently available processes for curing inflammation and related disorders facilitate the use of non steroidal anti-inflammatory drugs (NSAIDs)...
February 8, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28154178/green-tea-polyphenol-epigallocatechin-3-gallate-suppresses-toll-like-receptor-4-expression-via-upregulation-of-e3-ubiquitin-protein-ligase-rnf216
#11
Motofumi Kumazoe, Yuki Nakamura, Mai Yamashita, Takashi Suzuki, Kanako Takamatsu, Yuhui Huang, Jaehoon Bae, Shuya Yamashita, Motoki Murata, Shuhei Yamada, Yuki Shinoda, Wataru Yamaguchi, Yui Toyoda, Hirofumi Tachibana
Toll-like receptor 4 (TLR4) plays an essential role in innate immunity through inflammatory cytokine induction. Recent studies demonstrated that the abnormal activation of TLR4 has a pivotal role in obesity-induced inflammation, which is associated with several diseases, including hyperinsulinemia, hypertriglyceridemia, and cardiovascular disease. Here we demonstrate that (-)-epigallocatechin-3-O-gallate, a natural agonist of the 67-kDa laminin receptor (67LR), suppressed TLR4 expression through E3 ubiquitin-protein ring finger protein 216 (RNF216) upregulation...
February 1, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28152530/the-preventive-effect-of-coffee-compounds-on-dermatitis-and-epidermal-pigmentation-after-ultraviolet-irradiation-in-mice
#12
Yurika Yamate, Keiichi Hiramoto, Eisuke F Sato
BACKGROUND: Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear. METHODS: C57BL/6j male mice were irradiated with UVB (1.0 kJ/m2/day) for 3 days. Five days after the final session of UVB irradiation, the dorsal skin, ear epidermis, and blood samples were analyzed to investigate the inflammatory factors, melanogenesis factors and related hormones...
February 3, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28146410/almond-skin-polyphenol-extract-inhibits-inflammation-and-promotes-lipolysis-in-differentiated-3t3-l1-adipocytes
#13
Wen-Chung Huang, Chi-Yuan Chen, Shu-Ju Wu
Studies have shown that polyphenols reduce the risk of inflammation-related diseases and upregulates energy expenditure in adipose tissue. Here, we investigated the mechanism of the anti-inflammatory and antiobesity effects of almond skin polyphenol extract (ASP) in differentiated 3T3-L1 adipocytes. The antioxidant effects of ASP were measured based on DPPH radical scavenging activity, Trolox equivalent antioxidant capacity, and total phenolic content. Differentiated 3T3-L1 cells were treated with ASP. Subsequently, lipolysis proteins and transcription factors of adipogenesis were measured...
February 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28122695/environmental-enteric-dysfunction-is-associated-with-carnitine-deficiency-and-altered-fatty-acid-oxidation
#14
Richard D Semba, Indi Trehan, Ximin Li, Ruin Moaddel, M Isabel Ordiz, Kenneth M Maleta, Klaus Kraemer, Michelle Shardell, Luigi Ferrucci, Mark Manary
BACKGROUND: Environmental enteric dysfunction (EED), a condition characterized by small intestine inflammation and abnormal gut permeability, is widespread in children in developing countries and a major cause of growth failure. The pathophysiology of EED remains poorly understood. METHODS: We measured serum metabolites using liquid chromatography-tandem mass spectrometry in 400 children, aged 12-59months, from rural Malawi. Gut permeability was assessed by the dual-sugar absorption test...
January 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28119101/investigations-on-anti-inflammatory-and-analgesic-activities-of-alnus-nitida-spach-endl-stem-bark-in-sprague-dawley-rats
#15
Moniba Sajid, Muhammad Rashid Khan, Sayed Afzal Shah, Muhammad Majid, Hammad Ismail, Sonia Maryam, Riffat Batool, Tahira Younis
ETHNOPHARMACOLOGICAL RELEVANCE: Stem bark of Alnus nitida (Spach) Endl. (family Betulaceae) is used by local communities in northern areas of Pakistan as a remedy for swelling, injuries and pain. However no pharmacological study of this plant has been reported to confirm these activities. In this study anti-inflammatory and analgesic effect of A. nitida stem bark have been evaluated. METHODS: Powder of the stem bark of A. nitida was extracted with methanol (ANBM) and partitioned in escalating polarity to get the n-hexane (ANBH), chloroform (ANBC), ethyl acetate (ANBE) and the residual soluble aqueous (ANBA) fractions...
January 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28113103/two-dietary-polyphenols-fisetin-and-luteolin-reduce-inflammation-but-augment-dna-damage-induced-toxicity-in-human-rpe-cells
#16
Maria Hytti, Dora Szabó, Niina Piippo, Eveliina Korhonen, Paavo Honkakoski, Kai Kaarniranta, Goran Petrovski, Anu Kauppinen
Plant-derived polyphenols are known to possess anti-inflammatory and antioxidant effects. In recent years, several studies have investigated their potential benefits for treating chronic diseases associated with prolonged inflammation and excessive oxidative stress, such as age-related macular degeneration (AMD). Previously, two polyphenols, fisetin and luteolin, have been reported to increase the survival of retinal pigment epithelial (RPE) cells suffering from oxidative stress as well as decreasing inflammation but the benefits of polyphenol therapy seem to depend on the model system used...
January 9, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28110193/effects-of-polyphenol-compounds-melanin-on-nafld-nash-prevention
#17
Natalia Belemets, Nazarii Kobyliak, Oleksandr Virchenko, Tetyana Falalyeyeva, Tsyryuk Olena, Petro Bodnar, Oleksiy Savchuk, Tetyana Galenova, Martin Caprnda, Luis Rodrigo, Lubomir Skladany, Delian Delev, Radka Opatrilova, Peter Kruzliak, Tetyana Beregova, Lyudmyla Ostapchenko
BACKGROUND: One of the pathogenic mechanisms of the progression non-alcoholic liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) is the accumulation of reactive oxygen species (ROS). So, antioxidant therapy is necessary for successful treatment of the liver injury. We have paid attention to melanin produced by yeast Nadsoniella nigra strain X-1 as novel antioxidant and anti-inflammatory agents with low toxicity. In current study we aimed to investigate the preventive effect of melanin on the monosodium glutamate (MSG) induced NAFLD model in rats...
January 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28076319/impact-of-nutrition-on-pollutant-toxicity-an-update-with-new-insights-into-epigenetic-regulation
#18
Jessie B Hoffman, Michael C Petriello, Bernhard Hennig
Exposure to environmental pollutants is a global health problem and is associated with the development of many chronic diseases, including cardiovascular disease, diabetes and metabolic syndrome. There is a growing body of evidence that nutrition can both positively and negatively modulate the toxic effects of pollutant exposure. Diets high in proinflammatory fats, such as linoleic acid, can exacerbate pollutant toxicity, whereas diets rich in bioactive and anti-inflammatory food components, including omega-3 fatty acids and polyphenols, can attenuate toxicant-associated inflammation...
January 11, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28070834/resveratrol-modulates-gsh-system-in-c6-astroglial-cells-through-heme-oxygenase-1-pathway
#19
Bernardo Assein Arús, Débora Guerini Souza, Bruna Bellaver, Diogo Onofre Souza, Carlos-Alberto Gonçalves, André Quincozes-Santos, Larissa Daniele Bobermin
Resveratrol is a dietary polyphenol that displays neuroprotective properties in several in vivo and in vitro experimental models, by modulating oxidative and inflammatory responses. Glutathione (GSH) is a key antioxidant in the central nervous system (CNS) that modulates several cellular processes, and its depletion is associated with oxidative stress and inflammation. Therefore, this study sought to investigate the protective effects of resveratrol against GSH depletion pharmacologically induced by buthionine sulfoximine (BSO) in C6 astroglial cells, as well as its underlying cellular mechanisms...
January 9, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28067377/luteolin-suppresses-the-jak-stat-pathway-in-a-cellular-model-of-intestinal-inflammation
#20
Carla Nunes, Leonor Almeida, Rui M Barbosa, João Laranjinha
Current treatment strategies for inflammatory bowel diseases (IBDs) are associated with a lower efficacy and with several side effects that strongly affect the quality of life of IBD patients. Consequently, the development of new therapies, combining efficacy and safety is an important goal in the field of intestinal inflammation. In this context, evidence supports that polyphenols can be promising candidates due to their ability to modulate intracellular inflammatory signalling cascades. Luteolin, a naturally occurring flavonoid, exhibits anti-inflammatory properties in several models of inflammation...
January 9, 2017: Food & Function
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