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Jeffrey carson

Aaron A R Tobian, Nancy M Heddle, Theresa L Wiegmann, Jeffrey L Carson
No abstract text is available yet for this article.
October 2016: Transfusion
Jeffrey L Carson, Gordon Guyatt, Nancy M Heddle, Brenda J Grossman, Claudia S Cohn, Mark K Fung, Terry Gernsheimer, John B Holcomb, Lewis J Kaplan, Louis M Katz, Nikki Peterson, Glenn Ramsey, Sunil V Rao, John D Roback, Aryeh Shander, Aaron A R Tobian
Importance: More than 100 million units of blood are collected worldwide each year, yet the indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to transfusion are uncertain. Objective: To provide recommendations for the target hemoglobin level for RBC transfusion among hospitalized adult patients who are hemodynamically stable and the length of time RBCs should be stored prior to transfusion. Evidence Review: Reference librarians conducted a literature search for randomized clinical trials (RCTs) evaluating hemoglobin thresholds for RBC transfusion (1950-May 2016) and RBC storage duration (1948-May 2016) without language restrictions...
October 12, 2016: JAMA: the Journal of the American Medical Association
Jeffrey L Carson, Simon J Stanworth, Nareg Roubinian, Dean A Fergusson, Darrell Triulzi, Carolyn Doree, Paul C Hebert
BACKGROUND: There is considerable uncertainty regarding the optimal haemoglobin threshold for the use of red blood cell (RBC) transfusions in anaemic patients. Blood is a scarce resource, and in some countries, transfusions are less safe than others because of a lack of testing for viral pathogens. Therefore, reducing the number and volume of transfusions would benefit patients. OBJECTIVES: The aim of this review was to compare 30-day mortality and other clinical outcomes in participants randomized to restrictive versus liberal red blood cell (RBC) transfusion thresholds (triggers) for all conditions...
October 12, 2016: Cochrane Database of Systematic Reviews
Megan C Duggan, Caroline Jochems, Renee N Donahue, Jacob Richards, Volodymyr Karpa, Elizabeth Foust, Bonnie Paul, Taylor Brooks, Susheela Tridandapani, Thomas Olencki, Xueliang Pan, Gregory B Lesinski, Jeffrey Schlom, William E Carson Iii
Prime-boost vaccination with recombinant (r) vaccinia(V)-CEA(6D)-TRICOM (triad of co-stimulatory molecules B7.1, ICAM-1 and LFA-3) and rFowlpox(F)-CEA(6D)-TRICOM infect antigen-presenting cells and direct expression of co-stimulatory molecules. We hypothesized that co-administration of vaccine with GM-CSF and interferon alpha (IFN-α) would have efficacy in CEA-expressing cancers. Patients with CEA-expressing cancers received the rV-CEA(6D)-TRICOM vaccine subcutaneously (s.c.) on day 1 followed by GM-CSF s...
August 31, 2016: Cancer Immunology, Immunotherapy: CII
Walter Kostich, Brian D Hamman, Yu-Wen Li, Sreenivasulu Naidu, Kumaran Dandapani, Jianlin Feng, Amy Easton, Clotilde Bourin, Kevin Baker, Jason Allen, Katerina Savelieva, Justin V Louis, Manoj Dokania, Saravanan Elavazhagan, Pradeep Vattikundala, Vivek Sharma, Manish Lal Das, Ganesh Shankar, Anoop Kumar, Vinay K Holenarsipur, Michael Gulianello, Ted Molski, Jeffrey M Brown, Martin Lewis, Yanling Huang, Yifeng Lu, Rick Pieschl, Kevin O'Malley, Jonathan Lippy, Amr Nouraldeen, Thomas H Lanthorn, Guilan Ye, Alan Wilson, Anand Balakrishnan, Rex Denton, James E Grace, Kimberley A Lentz, Kenneth S Santone, Yingzhi Bi, Alan Main, Jon Swaffield, Ken Carson, Sandhya Mandlekar, Reeba K Vikramadithyan, Susheel J Nara, Carolyn Dzierba, Joanne Bronson, John E Macor, Robert Zaczek, Ryan Westphal, Laszlo Kiss, Linda Bristow, Charles M Conway, Brian Zambrowicz, Charles F Albright
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (hot plate, phase I formalin), but a markedly reduced response to persistent pain in phase II formalin. AAK1 knockout mice also failed to develop tactile allodynia following the Chung procedure of spinal nerve ligation (SNL)...
September 2016: Journal of Pharmacology and Experimental Therapeutics
Joshua E Mangum, Justin P Hardee, Dennis K Fix, Melissa J Puppa, Johnathon Elkes, Diego Altomare, Yelena Bykhovskaya, Dean R Campagna, Paul J Schmidt, Anoop K Sendamarai, Hart G W Lidov, Shayne C Barlow, Nathan Fischel-Ghodsian, Mark D Fleming, James A Carson, Jeffrey R Patton
Mitochondrial myopathy with lactic acidosis and sideroblastic anemia (MLASA) is an oxidative phosphorylation disorder, with primary clinical manifestations of myopathic exercise intolerance and a macrocytic sideroblastic anemia. One cause of MLASA is recessive mutations in PUS1, which encodes pseudouridine (Ψ) synthase 1 (Pus1p). Here we describe a mouse model of MLASA due to mutations in PUS1. As expected, certain Ψ modifications were missing in cytoplasmic and mitochondrial tRNAs from Pus1(-/-) animals...
2016: Scientific Reports
Matthew A Dale, Wanfen Xiong, Jeffrey S Carson, Melissa K Suh, Andrew D Karpisek, Trevor M Meisinger, George P Casale, B Timothy Baxter
Abdominal aortic aneurysm is a dynamic vascular disease characterized by inflammatory cell invasion and extracellular matrix degradation. Damage to elastin in the extracellular matrix results in release of elastin-derived peptides (EDPs), which are chemotactic for inflammatory cells such as monocytes. Their effect on macrophage polarization is less well known. Proinflammatory M1 macrophages initially are recruited to sites of injury, but, if their effects are prolonged, they can lead to chronic inflammation that prevents normal tissue repair...
June 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Nareg Roubinian, Jeffrey L Carson
Anemia in patients with malignancy is common as a consequence of their disease and treatment. Substantial progress has been made in the management of anemia with red blood cell transfusion in acute conditions, such as bleeding and infection, through the performance of large clinical trials. These trials suggest that transfusion at lower hemoglobin thresholds (restrictive transfusion ∼7-8 g/dL) is safe and in some cases superior to higher transfusion thresholds (liberal transfusion ∼9-10 g/dL). However, additional studies are needed in patients with malignancy to understand best practice in relation to quality of life as well as clinical outcomes...
June 2016: Hematology/oncology Clinics of North America
Rigel J Kishton, Carson E Barnes, Amanda G Nichols, Sivan Cohen, Valerie A Gerriets, Peter J Siska, Andrew N Macintyre, Pankuri Goraksha-Hicks, Aguirre A de Cubas, Tingyu Liu, Marc O Warmoes, E Dale Abel, Allen Eng Juh Yeoh, Timothy R Gershon, W Kimryn Rathmell, Kristy L Richards, Jason W Locasale, Jeffrey C Rathmell
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with Notch pathway mutations. While both normal activated and leukemic T cells can utilize aerobic glycolysis to support proliferation, it is unclear to what extent these cell populations are metabolically similar and if differences reveal T-ALL vulnerabilities. Here we show that aerobic glycolysis is surprisingly less active in T-ALL cells than proliferating normal T cells and that T-ALL cells are metabolically distinct. Oncogenic Notch promoted glycolysis but also induced metabolic stress that activated 5' AMP-activated kinase (AMPK)...
April 12, 2016: Cell Metabolism
Margaret W Leigh, Thomas W Ferkol, Stephanie D Davis, Hye-Seung Lee, Margaret Rosenfeld, Sharon D Dell, Scott D Sagel, Carlos Milla, Kenneth N Olivier, Kelli M Sullivan, Maimoona A Zariwala, Jessica E Pittman, Adam J Shapiro, Johnny L Carson, Jeffrey Krischer, Milan J Hazucha, Michael R Knowles
RATIONALE: Primary ciliary dyskinesia (PCD), a genetically heterogeneous, recessive disorder of motile cilia, is associated with distinct clinical features. Diagnostic tests, including ultrastructural analysis of cilia, nasal nitric oxide measurements, and molecular testing for mutations in PCD genes, have inherent limitations. OBJECTIVES: To define a statistically valid combination of systematically defined clinical features that strongly associates with PCD in children and adolescents...
August 2016: Annals of the American Thoracic Society
Bridget K Dolan, Amy V Van Hecke, Audrey M Carson, Jeffrey S Karst, Sheryl Stevens, Kirsten A Schohl, Stephanie Potts, Jenna Kahne, Nina Linneman, Rheanna Remmel, Emily Hummel
This study aimed to evaluate the effectiveness of a randomized controlled trial of a social skills intervention, the Program for the Education and Enrichment of Relational Skills (PEERS: Laugeson et al. in J Autism Dev Disord 39(4): 596-606, 2009), by coding digitally recorded social interactions between adolescent participants with ASD and a typically developing adolescent confederate. Adolescent participants engaged in a 10-min peer interaction at pre- and post-treatment. Interactions were coded using the Contextual Assessment of Social Skills (Ratto et al...
June 2016: Journal of Autism and Developmental Disorders
Wassim H Fares, Lavanya Bellumkonda, Adriano R Tonelli, Shannon S Carson, Paul M Hassoun, Terence K Trow, Erica L Herzog, Naftali Kaminski, Cyrus A Kholdani, Lixia Zhang, Yi Zhou, Jeffrey P Hammel, Raed A Dweik
BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive, fatal disease. Current prognostic models are not ideal, and identifying more accurate prognostic variables is needed. The objective of this study was to evaluate the relative prognostic value of the right atrial pressure/pulmonary artery wedge pressure (RAP/PAWP) ratio in PAH patients. We hypothesized that the RAP/PAWP ratio is more predictive of survival than any of the other measured or calculated hemodynamic variables...
June 2016: Journal of Heart and Lung Transplantation
Lynden K Shalm, Evan Meyer-Scott, Bradley G Christensen, Peter Bierhorst, Michael A Wayne, Martin J Stevens, Thomas Gerrits, Scott Glancy, Deny R Hamel, Michael S Allman, Kevin J Coakley, Shellee D Dyer, Carson Hodge, Adriana E Lita, Varun B Verma, Camilla Lambrocco, Edward Tortorici, Alan L Migdall, Yanbao Zhang, Daniel R Kumor, William H Farr, Francesco Marsili, Matthew D Shaw, Jeffrey A Stern, Carlos Abellán, Waldimar Amaya, Valerio Pruneri, Thomas Jennewein, Morgan W Mitchell, Paul G Kwiat, Joshua C Bienfang, Richard P Mirin, Emanuel Knill, Sae Woo Nam
We present a loophole-free violation of local realism using entangled photon pairs. We ensure that all relevant events in our Bell test are spacelike separated by placing the parties far enough apart and by using fast random number generators and high-speed polarization measurements. A high-quality polarization-entangled source of photons, combined with high-efficiency, low-noise, single-photon detectors, allows us to make measurements without requiring any fair-sampling assumptions. Using a hypothesis test, we compute p values as small as 5...
December 18, 2015: Physical Review Letters
Razelle Kurzrock, A Dimitrios Colevas, Anthony Olszanski, Wallace Akerley, Carlos L Arteaga, William E Carson, Jeffrey W Clark, John F DiPersio, David S Ettinger, Robert J Morgan, Lee S Schwartzberg, Alan P Venook, Christopher D Gocke, Jonathan Tait, F Marc Stewart
BACKGROUND: With advances such as next-generation sequencing (NGS) increasing understanding of the basis of cancer and its response to treatment, NCCN believes it is important to understand how molecular profiling/diagnostic testing is being performed and used at NCCN Member Institutions and their community affiliates. METHODS: The NCCN Oncology Research Program's Investigator Steering Committee and the NCCN Best Practices Committee gathered baseline information on the use of cancer-related molecular testing at NCCN Member Institutions and community members of the NCCN Affiliate Research Consortium through 2 separate surveys distributed in December 2013 and September 2014, respectively...
November 2015: Journal of the National Comprehensive Cancer Network: JNCCN
Matthew A Dale, Melissa K Suh, Shijia Zhao, Trevor Meisinger, Linxia Gu, Vicki J Swier, Devendra K Agrawal, Timothy C Greiner, Jeffrey S Carson, B Timothy Baxter, Wanfen Xiong
OBJECTIVE: Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are less susceptible to aneurysm formation compared to the 129/SvEv genetic background. In this study, we hypothesize that susceptibility to abdominal aortic aneurysm (AAA) will be increased in 129/SvEv mice versus C57Bl/6 mice...
December 2015: Atherosclerosis
Indu Ayappa, Jag Sunderram, Kathleen Black, Akosua Twumasi, Iris Udasin, Denise Harrison, Jeffrey L Carson, Shou-En Lu, David M Rapoport
BACKGROUND: Following the World Trade Center disaster, a large number of individuals involved in rescue and recovery activity were exposed to significant amounts of dust, and reported symptoms of chronic nasal and sinus inflammation. An unusually high prevalence of obstructive sleep apnea (OSA) has also been observed in this World Trade Center Responder population. This project aims to examine the relationship between nasal pathology and OSA. Our hypothesis is that increased nasal resistance due to nasal inflammation predisposes to OSA in this population...
2015: Trials
Jeffrey L Carson
No abstract text is available yet for this article.
March 2015: Clinical Advances in Hematology & Oncology: H&O
Zhiyong Zhang, Louis F Amorosa, Susette M Coyle, Marie A Macor, Sara E Lubitz, Jeffrey L Carson, Morris J Birnbaum, Leonard Y Lee, Beatrice Haimovich
LPS-induced TLR4 activation alters cellular bioenergetics and triggers proteolytic cleavage of AMPKα and HIF-1α expression in leukocytes. In human leukocytes, and more specifically neutrophils, AMPKα cleavage yields 55- and 35-kDa protein fragments. In this study, we address the mechanism by which AMPKα is cleaved and its relevance to human health. Our data indicate that AMPKα cleavage is linked to MMP9 expression and that both are required for mammalian target of rapamycin complex-1 and S6K1 activation and HIF-1α expression in LPS-stimulated human and mice leukocytes...
September 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Nareg H Roubinian, Jeffrey L Carson
No abstract text is available yet for this article.
October 2015: Evidence-based Medicine
Lauren A Beaupre, Jeffrey L Carson, Helaine Noveck, Jay Magaziner
OBJECTIVES: To compare risk-adjusted differences between men and women 30 and 60 days after hip fracture surgery in not walking, ability to return home in a community-dwelling subset, not walking in a nursing home resident subset, and mortality within 60 days. DESIGN: Cohort study. SETTING: Data were from a randomized clinical trial that compared two blood transfusion protocols after hip fracture. PARTICIPANTS: Individuals with hip fracture (N = 2,016; 489 (24%) male)...
August 2015: Journal of the American Geriatrics Society
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