keyword
MENU ▼
Read by QxMD icon Read
search

Jeffrey carson

keyword
https://www.readbyqxmd.com/read/29275509/examining-the-links-between-challenging-behaviors-in-youth-with-asd-and-parental-stress-mental-health-and-involvement-applying-an-adaptation-of-the-family-stress-model-to-families-of-youth-with-asd
#1
Hillary K Schiltz, Alana J McVey, Brooke Magnus, Bridget K Dolan, Kirsten S Willar, Sheryl Pleiss, Jeffrey Karst, Audrey M Carson, Christina Caiozzo, Elisabeth Vogt, Amy Vaughan Van Hecke
Raising a child with autism spectrum disorder (ASD) poses unique challenges that may impact parents' mental health and parenting experiences. The current study analyzed self-report data from 77 parents of youth with ASD. A serial multiple mediation model revealed that parenting stress (SIPA) and parental mental health (BAI and BDI-II) appears to be impacted by challenging adolescent behaviors (SSIS-PBs) and, in turn, affect parental involvement (PRQ), controlling for social skills (SSIS-SSs). Further, the study explored the malleability of parents' mental health over the course of a social skills intervention, and provides modest evidence that parent depressive symptoms decline across intervention...
December 23, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29259756/vu6010608-a-novel-mglu7-nam-from-a-series-of-n-2-1h-1-2-4-triazol-1-yl-5-trifluoromethoxy-phenyl-benzamides
#2
Carson W Reed, Kevin M McGowan, Paul K Spearing, Branden J Stansley, Hanna F Roenfanz, Darren W Engers, Alice L Rodriguez, Eileen M Engelberg, Vincent B Luscombe, Matthew T Loch, Daniel H Remke, Jerri M Rook, Anna L Blobaum, P Jeffrey Conn, Colleen M Niswender, Craig W Lindsley
Herein, we report the structure-activity relationships within a series of mGlu7 NAMs based on an N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamide core with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4). Analogues in this series displayed steep SAR. Of these, VU6010608 (11a) emerged with robust efficacy in blocking high frequency stimulated long-term potentiation in electrophysiology studies.
December 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29243287/evaluation-of-the-effect-of-dabrafenib-and-metabolites-on-qtc-interval-in-patients-with-braf-v600-mutant-tumours
#3
Noelia Nebot, H T Arkenau, Jeffrey R Infante, Jason C Chandler, Andrew Weickhardt, Jason D Lickliter, John Sarantopoulos, Michael S Gordon, Gabriel Mak, Annie St-Pierre, Lihua Tang, Bijoyesh Mookerjee, Stanley W Carson, Siobhan Hayes, Kenneth F Grossmann
AIMS: The effect of repeat oral supratherapeutic dosing of the BRAF inhibitor dabrafenib on QTc interval was assessed in patients with BRAF V600-mutant tumours. METHODS: Part 1 of this phase 1, multicentre, 2-part study (BRF113773/NCT01738451) assessed safety/tolerability of dabrafenib 225 or 300 mg twice daily (BID) to inform part 2 dosing. Patients in part 2 received dabrafenib-matched placebo on day -1, single-dose dabrafenib 300 mg on day 1, 300 mg BID on days 2 to 7, and 300 mg on day 8 (morning), followed by 24-hour Holter electrocardiographic monitoring and pharmacokinetics sample collection each dose day...
December 15, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29217508/il-1%C3%AE-interleukin-1%C3%AE-and-tnf-%C3%AE-tumor-necrosis-factor-%C3%AE-impact-abdominal-aortic-aneurysm-formation-by-differential-effects-on-macrophage-polarization
#4
Rishi Batra, Melissa K Suh, Jeffrey S Carson, Matthew A Dale, Trevor M Meisinger, Matthew Fitzgerald, Patrick J Opperman, Jiangtao Luo, Iraklis I Pipinos, Wanfen Xiong, B Timothy Baxter
OBJECTIVE: Abdominal aortic aneurysms are inflammatory in nature and are associated with some risk factors that also lead to atherosclerotic occlusive disease, most notably smoking. The purpose of our study was to identify differential cytokine expression in patients with abdominal aortic aneurysm and those with atherosclerotic occlusive disease. Based on this analysis, we further explored and compared the mechanism of action of IL (interleukin)-1β versus TNF-α (tumor necrosis factor-α) in abdominal aortic aneurysm formation...
December 7, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29164445/changes-in-depressive-symptoms-among-adolescents-with-asd-completing-the-peers%C3%A2-social-skills-intervention
#5
Hillary K Schiltz, Alana J McVey, Bridget K Dolan, Kirsten S Willar, Sheryl Pleiss, Jeffrey S Karst, Audrey M Carson, Christina Caiozzo, Elisabeth M Vogt, Brianna D Yund, Amy Vaughan Van Hecke
Depression is a common concern among people with autism spectrum disorder (ASD) and is often associated with social skills and relationship challenges. The present data, from a randomized controlled trial, examined the effect of PEERS® on self-reported depressive symptoms via the Children's Depression Inventory (CDI) among 49 adolescents with ASD. Findings revealed that many CDI subscale scores declined (p's < 0.05) and were related to direct social contact on the Quality of Socialization Questionnaire at posttest (p's < 0...
November 21, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29115020/glycosylphosphatidylinositol-gpi-anchored-protein-deficiency-serves-as-a-reliable-reporter-of-pig-a-gene-mutation-support-from-an-in-vitro-assay-based-on-l5178y-tk-cells-and-the-cd90-2-antigen
#6
Jeffrey C Bemis, Svetlana L Avlasevich, Carson Labash, Page McKinzie, Javier Revollo, Vasily N Dobrovolsky, Stephen D Dertinger
Lack of cell surface glycosylphosphatidylinositol (GPI)-anchored protein(s) has been used as a reporter of Pig-a gene mutation in several model systems. As an extension of this work, our laboratory initiated development of an in vitro mutation assay based on the flow cytometric assessment of CD90.2 expression on the cell surface of the mouse lymphoma cell line L5178Y/Tk(+/-) . Cells were exposed to mutagenic and nonmutagenic compounds for 24 hr followed by washout and incubation for an additional 7 days. Following this mutant manifestation time, cells were labeled with fluorescent antibodies against CD90...
November 8, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29040313/premature-aortic-smooth-muscle-cell-differentiation-contributes-to-matrix-dysregulation-in-marfan-syndrome
#7
Matthew Dale, Matthew P Fitzgerald, Zhibo Liu, Trevor Meisinger, Andrew Karpisek, Laura N Purcell, Jeffrey S Carson, Paul Harding, Haili Lang, Panagiotis Koutakis, Rishi Batra, Constance J Mietus, George Casale, Iraklis Pipinos, B Timothy Baxter, Wanfen Xiong
Thoracic aortic aneurysm and dissection are life-threatening complications of Marfan syndrome (MFS). Studies of human and mouse aortic samples from late stage MFS demonstrate increased TGF-β activation/signaling and diffuse matrix changes. However, the role of the aortic smooth muscle cell (SMC) phenotype in early aneurysm formation in MFS has yet to be fully elucidated. As our objective, we investigated whether an altered aortic SMC phenotype plays a role in aneurysm formation in MFS. We describe previously unrecognized concordant findings in the aortas of a murine model of MFS, mgR, during a critical and dynamic phase of early development...
2017: PloS One
https://www.readbyqxmd.com/read/28953438/indications-for-and-adverse-effects-of-red-cell-transfusion
#8
REVIEW
Jeffrey L Carson, Darrell J Triulzi, Paul M Ness
New England Journal of Medicine, Volume 377, Issue 13, Page 1261-1272, September 2017.
September 28, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28882834/anemia-and-bleeding-in-thrombocytopenic-patients
#9
Jeffrey L Carson, Simon J Stanworth
No abstract text is available yet for this article.
September 7, 2017: Blood
https://www.readbyqxmd.com/read/28864634/evaluation-of-the-lysophosphatidic-acid-receptor-type-1-radioligand-11-c-bmt-136088-for-lung-imaging-in-rhesus-monkeys
#10
Jean-Dominique Gallezot, Nabeel B Nabulsi, Daniel Holden, Shu-Fei Lin, David Labaree, Jim Ropchan, Soheila Najafzadeh, David J Donnelly, Kai Cao, Samuel Bonacorsi, Jon Seiders, Jeffrey Roppe, Wendy Hayes, Yiyun Huang, Shuyan Du, Richard E Carson
The lysophosphatidic acid receptor type 1 (LPA1) is one of six known receptors of the extracellular signaling molecule LPA. It mediates effects such as cell proliferation, migration and differentiation. In the lung, LPA1 is involved in pathways leading, after lung tissue injury, to pulmonary fibrosis instead of normal healing, by mediating fibroblast recruitment and vascular leak. Thus, a LPA1 positron emission tomography (PET) radiotracer may be useful to study lung fibrosis, or to develop LPA1-targeting drugs...
September 1, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28833575/in-vivo-pig-a-and-micronucleus-study-of-the-prototypical-aneugen-vinblastine-sulfate
#11
Svetlana L Avlasevich, Carson Labash, Dorothea K Torous, Jeffrey C Bemis, James T MacGregor, Stephen D Dertinger
The Pig-a assay is being used in regulatory studies to evaluate the potential of agents to induce somatic cell gene mutations and an OECD test guideline is under development. A working group involved with establishing the guideline recently noted that representative aneugenic agents had not been evaluated, and to help fill this data gap Pig-a mutant phenotype and micronucleated reticulocyte frequencies were measured in an integrated study design to assess the mutagenic and cytogenetic damage responses to vinblastine sulfate exposure...
August 19, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28798251/lungmap-the-molecular-atlas-of-lung-development-program
#12
Maryanne E Ardini-Poleske, Robert Fred Clark, Charles Ansong, James P Carson, Richard A Corley, Gail H Deutsch, James S Hagood, Naftali Kaminski, Thomas J Mariani, Steven S Potter, Gloria S Pryhuber, David Warburton, Jeffrey A Whitsett, Scott M Palmer, Namasivayam Ambalavanan, The LungMAP Consortium
The National Heart Lung and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic crosstalk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults...
August 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28754951/mass-spectrometry-based-determination-of-kallikrein-related-peptidase-7-klk7-cleavage-preferences-and-subsite-dependency
#13
Lakmali Munasinghage Silva, Thomas Stoll, Thomas Kryza, Carson Ryan Stephens, Marcus Lachlan Hastie, Helen Frances Irving-Rodgers, Ying Dong, Jeffrey John Gorman, Judith Ann Clements
The cleavage preferences of Kallikrein-related peptidase 7 (KLK7) have previously been delineated using synthetic peptide libraries of fixed length, or single protein chains and have suggested that KLK7 exerts a chymotryptic-like cleavage preference. Due to the short length of the peptides utilised, only a limited number of subsites have however been assessed. To determine the subsite preferences of KLK7 in a global setting, we used a mass spectrometry (MS)-based in-depth proteomics approach that utilises human proteome-derived peptide libraries of varying length, termed Proteomic Identification of protease Cleavage Sites (PICS)...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751600/contingent-valuation-flawed-logic-response
#14
LETTER
Richard C Bishop, Kevin J Boyle, Richard T Carson, David Chapman, W Michael Hanemann, Barbara Kanninen, Raymond J Kopp, Jon Krosnick, John List, Norman Meade, Robert Paterson, Stanley Presser, V Kerry Smith, Roger Tourangeau, Michael Welsh, Jeffrey M Wooldridge, Matthew De Bell, Colleen Donovan, Matthew Konopka, Nora Scherer
No abstract text is available yet for this article.
July 28, 2017: Science
https://www.readbyqxmd.com/read/28512184/effect-of-intensive-blood-pressure-lowering-on-left-ventricular-hypertrophy-in-patients-with-hypertension-sprint-systolic-blood-pressure-intervention-trial
#15
RANDOMIZED CONTROLLED TRIAL
Elsayed Z Soliman, Walter T Ambrosius, William C Cushman, Zhu-Ming Zhang, Jeffrey T Bates, Javier A Neyra, Thaddeus Y Carson, Leonardo Tamariz, Lama Ghazi, Monique E Cho, Brian P Shapiro, Jiang He, Lawrence J Fine, Cora E Lewis
BACKGROUND: It is currently unknown whether intensive blood pressure (BP) lowering beyond that recommended would lead to more lowering of the risk of left ventricular hypertrophy (LVH) in patients with hypertension and whether reducing the risk of LVH explains the reported cardiovascular disease (CVD) benefits of intensive BP lowering in this population. METHODS: This analysis included 8164 participants (mean age, 67.9 years; 35.3% women; 31.2% blacks) with hypertension but no diabetes mellitus from the SPRINT trial (Systolic Blood Pressure Intervention Trial): 4086 randomly assigned to intensive BP lowering (target SBP <120 mm Hg) and 4078 assigned to standard BP lowering (target SBP <140 mm Hg)...
August 1, 2017: Circulation
https://www.readbyqxmd.com/read/28463630/safety-and-activity-of-varlilumab-a-novel-and-first-in-class-agonist-anti-cd27-antibody-in-patients-with-advanced-solid-tumors
#16
Howard A Burris, Jeffrey R Infante, Stephen M Ansell, John J Nemunaitis, Geoffrey R Weiss, Victor M Villalobos, Branimir I Sikic, Matthew H Taylor, Donald W Northfelt, William E Carson, Thomas R Hawthorne, Thomas A Davis, Michael J Yellin, Tibor Keler, Timothy Bullock
Purpose CD27, a costimulatory molecule on T cells, induces intracellular signals that mediate cellular activation, proliferation, effector function, and cell survival upon binding to its ligand, CD70. Varlilumab is a novel, first-in-class, agonist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumor activity in tumor models. This first-in-human, dose-escalation and expansion study evaluated the safety, pharmacology, and activity of varlilumab in patients with advanced solid tumors...
June 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28428387/putting-a-value-on-injuries-to-natural-assets-the-bp-oil-spill
#17
Richard C Bishop, Kevin J Boyle, Richard T Carson, David Chapman, W Michael Hanemann, Barbara Kanninen, Raymond J Kopp, Jon A Krosnick, John List, Norman Meade, Robert Paterson, Stanley Presser, V Kerry Smith, Roger Tourangeau, Michael Welsh, Jeffrey M Wooldridge, Matthew DeBell, Colleen Donovan, Matthew Konopka, Nora Scherer
No abstract text is available yet for this article.
April 21, 2017: Science
https://www.readbyqxmd.com/read/28408004/development-of-the-diary-for-irritable-bowel-syndrome-symptoms-to-assess-treatment-benefit-in-clinical-trials-foundational-qualitative-research
#18
MULTICENTER STUDY
Sheri E Fehnel, Claire M Ervin, Robyn T Carson, Gianna Rigoni, Jeffrey M Lackner, Stephen Joel Coons
BACKGROUND: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and alterations in bowel habits. Three subtypes are defined on the basis of stool patterns: diarrhea-predominant IBS, constipation-predominant IBS, and alternating or mixed IBS. OBJECTIVES: To develop patient-reported outcome measures for qualification by the Food and Drug Administration to support product approvals and labeling in IBS; the article focuses on the qualitative research that provided the foundation for the new measures...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28391452/brief-report-does-gender-matter-in-intervention-for-asd-examining-the-impact-of-the-peers-%C3%A2-social-skills-intervention-on-social-behavior-among-females-with-asd
#19
Alana J McVey, Hillary Schiltz, Angela Haendel, Bridget K Dolan, Kirsten S Willar, Sheryl Pleiss, Jeffrey S Karst, Audrey M Carson, Christina Caiozzo, Elisabeth Vogt, Amy Vaughan Van Hecke
A paucity of research has been conducted to examine the effect of social skills intervention on females with ASD. Females with ASD may have more difficulty developing meaningful friendships than males, as the social climate can be more complex (Archer, Coyne, Personality and Social Psychology Review 9(3):212-230, 2005). This study examined whether treatment response among females differed from males. One hundred and seventy-seven adolescents and young adults with ASD (N = 177) participated in this study...
July 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28166236/a-high-throughput-mutagenic-analysis-of-yeast-sumo-structure-and-function
#20
Heather A Newman, Pamela B Meluh, Jian Lu, Jeremy Vidal, Caryn Carson, Elizabeth Lagesse, Jeffrey J Gray, Jef D Boeke, Michael J Matunis
Sumoylation regulates a wide range of essential cellular functions through diverse mechanisms that remain to be fully understood. Using S. cerevisiae, a model organism with a single essential SUMO gene (SMT3), we developed a library of >250 mutant strains with single or multiple amino acid substitutions of surface or core residues in the Smt3 protein. By screening this library using plate-based assays, we have generated a comprehensive structure-function based map of Smt3, revealing essential amino acid residues and residues critical for function under a variety of genotoxic and proteotoxic stress conditions...
February 2017: PLoS Genetics
keyword
keyword
100110
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"