Jeffrey L Carson, Maria Mori Brooks, Paul C Hébert, Shaun G Goodman, Marnie Bertolet, Simone A Glynn, Bernard R Chaitman, Tabassome Simon, Renato D Lopes, Andrew M Goldsweig, Andrew P DeFilippis, J Dawn Abbott, Brian J Potter, Francois Martin Carrier, Sunil V Rao, Howard A Cooper, Shahab Ghafghazi, Dean A Fergusson, William J Kostis, Helaine Noveck, Sarang Kim, Meechai Tessalee, Gregory Ducrocq, Pedro Gabriel Melo de Barros E Silva, Darrell J Triulzi, Caroline Alsweiler, Mark A Menegus, John D Neary, Lynn Uhl, Jordan B Strom, Christopher B Fordyce, Emile Ferrari, Johanne Silvain, Frances O Wood, Benoit Daneault, Tamar S Polonsky, Manohara Senaratne, Etienne Puymirat, Claire Bouleti, Benoit Lattuca, Harvey D White, Sheryl F Kelsey, P Gabriel Steg, John H Alexander
BACKGROUND: A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from a higher hemoglobin level. METHODS: In this phase 3, interventional trial, we randomly assigned patients with myocardial infarction and a hemoglobin level of less than 10 g per deciliter to a restrictive transfusion strategy (hemoglobin cutoff for transfusion, 7 or 8 g per deciliter) or a liberal transfusion strategy (hemoglobin cutoff, <10 g per deciliter)...
December 28, 2023: New England Journal of Medicine