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Jeffrey carson

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https://www.readbyqxmd.com/read/29754812/a-randomized-controlled-trial-to-evaluate-the-safety-and-efficacy-of-cardiac-contractility-modulation
#1
William T Abraham, Karl-Heinz Kuck, Rochelle L Goldsmith, JoAnn Lindenfeld, Vivek Y Reddy, Peter E Carson, Douglas L Mann, Benjamin Saville, Helen Parise, Rodrigo Chan, Phi Wiegn, Jeffrey L Hastings, Andrew J Kaplan, Frank Edelmann, Lars Luthje, Rami Kahwash, Gery F Tomassoni, David D Gutterman, Angela Stagg, Daniel Burkhoff, Gerd Hasenfuß
OBJECTIVES: The authors sought to confirm a subgroup analysis of the prior FIX-HF-5 (Evaluate Safety and Efficacy of the OPTIMIZER System in Subjects With Moderate-to-Severe Heart Failure) study showing that cardiac contractility modulation (CCM) improved exercise tolerance (ET) and quality of life in patients with ejection fractions between 25% and 45%. BACKGROUND: CCM therapy for New York Heart Association (NYHA) functional class III and IV heart failure (HF) patients consists of nonexcitatory electrical signals delivered to the heart during the absolute refractory period...
May 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29664879/surgical-treatment-of-supracondylar-humeral-fractures-in-a-freestanding-ambulatory-surgery-center-is-as-safe-as-and-faster-and-more-cost-effective-than-in-a-children-s-hospital
#2
Carson M Rider, Victor Y Hong, Timothy J Westbrooks, Jiajing Wang, Benjamin W Sheffer, Derek M Kelly, David D Spence, John M Flynn, Jeffrey R Sawyer
BACKGROUND: Despite an 88% increase in the number of pediatric fractures treated in ambulatory surgery centers (ASCs) over a 10-year period, few studies have compared outcomes of fracture treatment performed in a freestanding ASC compared with those performed in the hospital (HOSP) or hospital outpatient department (HOPD). The purpose of this study was to compare clinical and radiographic outcomes, treatment times, and costs for treatment of Gartland type II supracondylar humeral (SCH) fracture in the ASC, HOSP, and HOPD...
April 16, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29643105/a-next-generation-sequencing-based-assay-for-minimal-residual-disease-assessment-in-aml-patients-with-flt3-itd-mutations
#3
Mark J Levis, Alexander E Perl, Jessica K Altman, Christopher D Gocke, Erkut Bahceci, Jason Hill, Chaofeng Liu, Zhiyi Xie, Andrew R Carson, Valerie McClain, Timothy T Stenzel, Jeffrey E Miller
Internal tandem duplications in fms-like tyrosine kinase 3 ( FLT3- ITDs) are common in acute myeloid leukemia (AML) and confer a poor prognosis. A sensitive and specific assay for the detection of minimal residual disease (MRD) in FLT3- ITD mutated AML could guide therapy decisions. Existing assays for MRD in FLT3- ITD AML have not been particularly useful because of limited sensitivity. We developed a sensitive and specific MRD assay for FLT3- ITD mutations using next-generation sequencing. The initial validation of this assay was performed by spiking fixed amounts of mutant DNA into wild-type DNA to establish a sensitivity of detection equivalent to ≥1 FLT3- ITD-containing cell in 10 000, with a minimum input of 100 000 cell equivalents of DNA...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29608255/twenty-five-year-trajectories-of-insulin-resistance-and-pancreatic-%C3%AE-cell-response-and-diabetes-risk-in-nonalcoholic-fatty-liver-disease
#4
Lisa B VanWagner, Hongyan Ning, Norrina B Allen, Juned Siddique, April P Carson, Michael P Bancks, Cora E Lewis, John Jeffrey Carr, Elizabeth Speliotes, Norah A Terrault, Mary E Rinella, Miriam B Vos, Donald M Lloyd-Jones
BACKGROUND & AIMS: Insulin resistance is a risk marker for non-alcoholic fatty liver disease, and a risk factor for liver disease progression. We assessed temporal trajectories of insulin resistance and β-cell response to serum glucose concentration throughout adulthood and their association with diabetes risk in non-alcoholic fatty liver disease. METHODS: Three thousand and sixty participants from Coronary Artery Risk Development in Young Adults, a prospective bi-racial cohort of adults age 18-30 years at baseline (1985-1986; Y0) who completed up to 5 exams over 25 years and had fasting insulin and glucose measurement were included...
April 2, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29551447/bad-blood-or-sick-patient
#5
Ramy Sedhom, Roger Strair, Jeffrey L Carson
No abstract text is available yet for this article.
May 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29516783/time-resolved-proteome-profiling-of-normal-lung-development
#6
Ahmed Moghieb, Geremy Clair, Hugh Mitchell, Joseph A Kitzmiller, Erika M Zink, Young-Mo Kim, Vladislav Petyuk, Anil K Shukla, Ronald J Moore, Thomas O Metz, James P Carson, Jason E McDermott, Richard A Corley, Jeffrey A Whitsett, Charles Ansong
Biochemical networks mediating normal lung morphogenesis and function have important implications for ameliorating morbidity and mortality in premature infants. While several transcript-level studies have examined normal lung development, corresponding protein-level analyses are lacking. Here we performed proteomics analysis of murine lungs from embryonic to early adult ages to identify the molecular networks mediating normal lung development. We identified 8,932 proteins providing a deep and comprehensive view of the lung proteome...
March 8, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#7
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29385446/a-comparison-of-outcomes-between-canada-and-the-united-states-in-patients-recovering-from-hip-fracture-repair-secondary-analysis-of-the-focus-trial
#8
Lauren A Beaupre, Eugene K Wai, Donald R Hoover, Helaine Noveck, Darren M Roffey, Donald R Cook, Jay S Magaziner, Jeffrey L Carson
Objective: To determine if adjusted mortality, walking ability or return home differed after hip fracture surgery between Canada and the USA. Design: Secondary analysis of the Functional Outcomes in Cardiovascular Patients Undergoing Surgical Hip Fracture Repair (FOCUS) trial data. Setting: Data were collected from 47 American and Canadian hospitals. Participants: Overall, 2016 subjects with a hip fracture (USA = 1222 (60...
March 1, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29275509/examining-the-links-between-challenging-behaviors-in-youth-with-asd-and-parental-stress-mental-health-and-involvement-applying-an-adaptation-of-the-family-stress-model-to-families-of-youth-with-asd
#9
Hillary K Schiltz, Alana J McVey, Brooke Magnus, Bridget K Dolan, Kirsten S Willar, Sheryl Pleiss, Jeffrey Karst, Audrey M Carson, Christina Caiozzo, Elisabeth Vogt, Amy Vaughan Van Hecke
Raising a child with autism spectrum disorder (ASD) poses unique challenges that may impact parents' mental health and parenting experiences. The current study analyzed self-report data from 77 parents of youth with ASD. A serial multiple mediation model revealed that parenting stress (SIPA) and parental mental health (BAI and BDI-II) appears to be impacted by challenging adolescent behaviors (SSIS-PBs) and, in turn, affect parental involvement (PRQ), controlling for social skills (SSIS-SSs). Further, the study explored the malleability of parents' mental health over the course of a social skills intervention, and provides modest evidence that parent depressive symptoms decline across intervention...
April 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29259756/vu6010608-a-novel-mglu-7-nam-from-a-series-of-n-2-1-h-1-2-4-triazol-1-yl-5-trifluoromethoxy-phenyl-benzamides
#10
Carson W Reed, Kevin M McGowan, Paul K Spearing, Branden J Stansley, Hanna F Roenfanz, Darren W Engers, Alice L Rodriguez, Eileen M Engelberg, Vincent B Luscombe, Matthew T Loch, Daniel H Remke, Jerri M Rook, Anna L Blobaum, P Jeffrey Conn, Colleen M Niswender, Craig W Lindsley
Herein, we report the structure-activity relationships within a series of mGlu7 NAMs based on an N -(2-(1 H -1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamide core with excellent CNS penetration ( K p 1.9-5.8 and K p,uu 0.4-1.4). Analogues in this series displayed steep SAR. Of these, VU6010608 ( 11a ) emerged with robust efficacy in blocking high frequency stimulated long-term potentiation in electrophysiology studies.
December 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29243287/evaluation-of-the-effect-of-dabrafenib-and-metabolites-on-qtc-interval-in-patients-with-braf-v600-mutant-tumours
#11
Noelia Nebot, Hendrik-Tobias Arkenau, Jeffrey R Infante, Jason C Chandler, Andrew Weickhardt, Jason D Lickliter, John Sarantopoulos, Michael S Gordon, Gabriel Mak, Annie St-Pierre, Lihua Tang, Bijoyesh Mookerjee, Stanley W Carson, Siobhan Hayes, Kenneth F Grossmann
AIMS: The effect of repeat oral supratherapeutic dosing of the BRAF inhibitor dabrafenib on QTc interval was assessed in patients with BRAF V600-mutant tumours. METHODS: Part 1 of this phase 1, multicentre, 2-part study (BRF113773/NCT01738451) assessed safety/tolerability of dabrafenib 225 or 300 mg twice daily (BID) to inform part 2 dosing. Patients in part 2 received dabrafenib-matched placebo on day -1, single-dose dabrafenib 300 mg on day 1, 300 mg BID on days 2 to 7, and 300 mg on day 8 (morning), followed by 24-h Holter electrocardiographic monitoring and pharmacokinetics sample collection each dose day...
December 15, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29217508/il-1%C3%AE-interleukin-1%C3%AE-and-tnf-%C3%AE-tumor-necrosis-factor-%C3%AE-impact-abdominal-aortic-aneurysm-formation-by-differential-effects-on-macrophage-polarization
#12
Rishi Batra, Melissa K Suh, Jeffrey S Carson, Matthew A Dale, Trevor M Meisinger, Matthew Fitzgerald, Patrick J Opperman, Jiangtao Luo, Iraklis I Pipinos, Wanfen Xiong, B Timothy Baxter
OBJECTIVE: Abdominal aortic aneurysms are inflammatory in nature and are associated with some risk factors that also lead to atherosclerotic occlusive disease, most notably smoking. The purpose of our study was to identify differential cytokine expression in patients with abdominal aortic aneurysm and those with atherosclerotic occlusive disease. Based on this analysis, we further explored and compared the mechanism of action of IL (interleukin)-1β versus TNF-α (tumor necrosis factor-α) in abdominal aortic aneurysm formation...
February 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29164445/changes-in-depressive-symptoms-among-adolescents-with-asd-completing-the-peers-%C3%A2-social-skills-intervention
#13
Hillary K Schiltz, Alana J McVey, Bridget K Dolan, Kirsten S Willar, Sheryl Pleiss, Jeffrey S Karst, Audrey M Carson, Christina Caiozzo, Elisabeth M Vogt, Brianna D Yund, Amy Vaughan Van Hecke
Depression is a common concern among people with autism spectrum disorder (ASD) and is often associated with social skills and relationship challenges. The present data, from a randomized controlled trial, examined the effect of PEERS® on self-reported depressive symptoms via the Children's Depression Inventory (CDI) among 49 adolescents with ASD. Findings revealed that many CDI subscale scores declined (p's < 0.05) and were related to direct social contact on the Quality of Socialization Questionnaire at posttest (p's < 0...
March 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29115020/glycosylphosphatidylinositol-gpi-anchored-protein-deficiency-serves-as-a-reliable-reporter-of-pig-a-gene-mutation-support-from-an-in-vitro-assay-based-on-l5178y-tk-cells-and-the-cd90-2-antigen
#14
Jeffrey C Bemis, Svetlana L Avlasevich, Carson Labash, Page McKinzie, Javier Revollo, Vasily N Dobrovolsky, Stephen D Dertinger
Lack of cell surface glycosylphosphatidylinositol (GPI)-anchored protein(s) has been used as a reporter of Pig-a gene mutation in several model systems. As an extension of this work, our laboratory initiated development of an in vitro mutation assay based on the flow cytometric assessment of CD90.2 expression on the cell surface of the mouse lymphoma cell line L5178Y/Tk+/- . Cells were exposed to mutagenic and nonmutagenic compounds for 24 hr followed by washout and incubation for an additional 7 days. Following this mutant manifestation time, cells were labeled with fluorescent antibodies against CD90...
January 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29040313/premature-aortic-smooth-muscle-cell-differentiation-contributes-to-matrix-dysregulation-in-marfan-syndrome
#15
Matthew Dale, Matthew P Fitzgerald, Zhibo Liu, Trevor Meisinger, Andrew Karpisek, Laura N Purcell, Jeffrey S Carson, Paul Harding, Haili Lang, Panagiotis Koutakis, Rishi Batra, Constance J Mietus, George Casale, Iraklis Pipinos, B Timothy Baxter, Wanfen Xiong
Thoracic aortic aneurysm and dissection are life-threatening complications of Marfan syndrome (MFS). Studies of human and mouse aortic samples from late stage MFS demonstrate increased TGF-β activation/signaling and diffuse matrix changes. However, the role of the aortic smooth muscle cell (SMC) phenotype in early aneurysm formation in MFS has yet to be fully elucidated. As our objective, we investigated whether an altered aortic SMC phenotype plays a role in aneurysm formation in MFS. We describe previously unrecognized concordant findings in the aortas of a murine model of MFS, mgR, during a critical and dynamic phase of early development...
2017: PloS One
https://www.readbyqxmd.com/read/28953438/indications-for-and-adverse-effects-of-red-cell-transfusion
#16
REVIEW
Jeffrey L Carson, Darrell J Triulzi, Paul M Ness
New England Journal of Medicine, Volume 377, Issue 13, Page 1261-1272, September 2017.
September 28, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28882834/anemia-and-bleeding-in-thrombocytopenic-patients
#17
COMMENT
Jeffrey L Carson, Simon J Stanworth
No abstract text is available yet for this article.
September 7, 2017: Blood
https://www.readbyqxmd.com/read/28864634/evaluation-of-the-lysophosphatidic-acid-receptor-type-1-radioligand-11-c-bmt-136088-for-lung-imaging-in-rhesus-monkeys
#18
Jean-Dominique Gallezot, Nabeel B Nabulsi, Daniel Holden, Shu-Fei Lin, David Labaree, Jim Ropchan, Soheila Najafzadeh, David J Donnelly, Kai Cao, Samuel Bonacorsi, Jon Seiders, Jeffrey Roppe, Wendy Hayes, Yiyun Huang, Shuyan Du, Richard E Carson
The lysophosphatidic acid receptor type 1 (LPA1) is 1 of 6 known receptors of the extracellular signaling molecule lysophosphatidic acid. It mediates effects such as cell proliferation, migration, and differentiation. In the lung, LPA1 is involved in pathways leading, after lung tissue injury, to pulmonary fibrosis instead of normal healing, by mediating fibroblast recruitment and vascular leakage. Thus, a LPA1 PET radiotracer may be useful for studying lung fibrosis or for developing LPA1-targeting drugs. We developed and evaluated the radiotracer 11 C-BMT-136088 (1-(4'-(3-methyl-4-(((1( R )-(3-11 C-methylphenyl)ethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid) in rhesus monkeys to image LPA1 in the lung in vivo with PET...
February 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28833575/in-vivo-pig-a-and-micronucleus-study-of-the-prototypical-aneugen-vinblastine-sulfate
#19
Svetlana L Avlasevich, Carson Labash, Dorothea K Torous, Jeffrey C Bemis, James T MacGregor, Stephen D Dertinger
The Pig-a assay is being used in regulatory studies to evaluate the potential of agents to induce somatic cell gene mutations and an OECD test guideline is under development. A working group involved with establishing the guideline recently noted that representative aneugenic agents had not been evaluated, and to help fill this data gap Pig-a mutant phenotype and micronucleated reticulocyte frequencies were measured in an integrated study design to assess the mutagenic and cytogenetic damage responses to vinblastine sulfate exposure...
January 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28798251/lungmap-the-molecular-atlas-of-lung-development-program
#20
REVIEW
Maryanne E Ardini-Poleske, Robert F Clark, Charles Ansong, James P Carson, Richard A Corley, Gail H Deutsch, James S Hagood, Naftali Kaminski, Thomas J Mariani, Steven S Potter, Gloria S Pryhuber, David Warburton, Jeffrey A Whitsett, Scott M Palmer, Namasivayam Ambalavanan
The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults...
November 1, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
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