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Jeffrey carson

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https://www.readbyqxmd.com/read/28428387/putting-a-value-on-injuries-to-natural-assets-the-bp-oil-spill
#1
Richard C Bishop, Kevin J Boyle, Richard T Carson, David Chapman, W Michael Hanemann, Barbara Kanninen, Raymond J Kopp, Jon A Krosnick, John List, Norman Meade, Robert Paterson, Stanley Presser, V Kerry Smith, Roger Tourangeau, Michael Welsh, Jeffrey M Wooldridge, Matthew DeBell, Colleen Donovan, Matthew Konopka, Nora Scherer
No abstract text is available yet for this article.
April 21, 2017: Science
https://www.readbyqxmd.com/read/28408004/development-of-the-diary-for-irritable-bowel-syndrome-symptoms-to-assess-treatment-benefit-in-clinical-trials-foundational-qualitative-research
#2
MULTICENTER STUDY
Sheri E Fehnel, Claire M Ervin, Robyn T Carson, Gianna Rigoni, Jeffrey M Lackner, Stephen Joel Coons
BACKGROUND: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and alterations in bowel habits. Three subtypes are defined on the basis of stool patterns: diarrhea-predominant IBS, constipation-predominant IBS, and alternating or mixed IBS. OBJECTIVES: To develop patient-reported outcome measures for qualification by the Food and Drug Administration to support product approvals and labeling in IBS; the article focuses on the qualitative research that provided the foundation for the new measures...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28391452/brief-report-does-gender-matter-in-intervention-for-asd-examining-the-impact-of-the-peers-%C3%A2-social-skills-intervention-on-social-behavior-among-females-with-asd
#3
Alana J McVey, Hillary Schiltz, Angela Haendel, Bridget K Dolan, Kirsten S Willar, Sheryl Pleiss, Jeffrey S Karst, Audrey M Carson, Christina Caiozzo, Elisabeth Vogt, Amy Vaughan Van Hecke
A paucity of research has been conducted to examine the effect of social skills intervention on females with ASD. Females with ASD may have more difficulty developing meaningful friendships than males, as the social climate can be more complex (Archer, Coyne, Personality and Social Psychology Review 9(3):212-230, 2005). This study examined whether treatment response among females differed from males. One hundred and seventy-seven adolescents and young adults with ASD (N = 177) participated in this study...
April 8, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28166236/a-high-throughput-mutagenic-analysis-of-yeast-sumo-structure-and-function
#4
Heather A Newman, Pamela B Meluh, Jian Lu, Jeremy Vidal, Caryn Carson, Elizabeth Lagesse, Jeffrey J Gray, Jef D Boeke, Michael J Matunis
Sumoylation regulates a wide range of essential cellular functions through diverse mechanisms that remain to be fully understood. Using S. cerevisiae, a model organism with a single essential SUMO gene (SMT3), we developed a library of >250 mutant strains with single or multiple amino acid substitutions of surface or core residues in the Smt3 protein. By screening this library using plate-based assays, we have generated a comprehensive structure-function based map of Smt3, revealing essential amino acid residues and residues critical for function under a variety of genotoxic and proteotoxic stress conditions...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28135150/phase-iii-randomized-study-of-4-weeks-of-high-dose-interferon-%C3%AE-2b-in-stage-t2bno-t3a-bno-t4a-bno-and-t1-4n1a-2a-microscopic-melanoma-a-trial-of-the-eastern-cooperative-oncology-group-american-college-of-radiology-imaging-network-cancer-research-group-e1697
#5
Sanjiv S Agarwala, Sandra J Lee, Waiki Yip, Uma N Rao, Ahmad A Tarhini, Gary I Cohen, Douglas S Reintgen, Terry L Evans, Joanna M Brell, Mark R Albertini, Michael B Atkins, Shaker R Dakhil, Robert M Conry, Jeffrey A Sosman, Lawrence E Flaherty, Vernon K Sondak, William E Carson, Michael G Smylie, Alberto S Pappo, Richard F Kefford, John M Kirkwood
Purpose To test the efficacy of 4 weeks of intravenous (IV) induction with high-dose interferon (IFN) as part of the Eastern Cooperative Oncology Group regimen compared with observation (OBS) in patients with surgically resected intermediate-risk melanoma. Patients and Methods In this intergroup international trial, eligible patients had surgically resected cutaneous melanoma in the following categories: (1) T2bN0, (2) T3a-bN0, (3) T4a-bN0, and (4) T1-4N1a-2a (microscopic). Patients were randomly assigned to receive IFN α-2b at 20 MU/m(2)/d IV for 5 days (Monday to Friday) every week for 4 weeks (IFN) or OBS...
March 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28004771/spatially-resolved-proteomics-rapid-quantitative-analysis-of-laser-capture-microdissected-alveolar-tissue-samples
#6
Geremy Clair, Paul D Piehowski, Teodora Nicola, Joseph A Kitzmiller, Eric L Huang, Erika M Zink, Ryan L Sontag, Daniel J Orton, Ronald J Moore, James P Carson, Richard D Smith, Jeffrey A Whitsett, Richard A Corley, Namasivayam Ambalavanan, Charles Ansong
Laser capture microdissection (LCM)-enabled region-specific tissue analyses are critical to better understand complex multicellular processes. However, current proteomics workflows entail several manual sample preparation steps and are challenged by the microscopic mass-limited samples generated by LCM, impacting measurement robustness, quantification and throughput. Here, we coupled LCM with a proteomics workflow that provides fully automated analysis of proteomes from microdissected tissues. Benchmarking against the current state-of-the-art in ultrasensitive global proteomics (FASP workflow), our approach demonstrated significant improvements in quantification (~2-fold lower variance) and throughput (>5 times faster)...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27906086/massive-adrenal-vein-aneurysm-mimicking-an-adrenal-tumor-in-a-patient-with-hemophilia-a-a-case-report-and-review-of-the-literature
#7
Richard Sleightholm, Steven Wahlmeier, Jeffrey S Carson, Andjela Drincic, Audrey Lazenby, Jason M Foster
BACKGROUND: Visceral venous aneurysms are exceedingly rare, and until now, there have been no reports of this phenomenon in the adrenal vasculature. This report details the first adrenal venous aneurysm reported in the literature. The aneurysm presented as an 18-cm mass that was initially suspected to be a hematoma or tumor on the basis of the complex medical history of the patient, which included hemophilia A and testicular cancer. After surgical excision, pathologic examination confirmed this mass to be a 15...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27852723/regional-versus-general-anesthesia-for-promoting-independence-after-hip-fracture-regain-protocol-for-a-pragmatic-international-multicentre-trial
#8
Mark D Neuman, Susan S Ellenberg, Frederick E Sieber, Jay S Magaziner, Rui Feng, Jeffrey L Carson
INTRODUCTION: Hip fractures occur 1.6 million times each year worldwide, with substantial associated mortality and losses of independence. At present, anaesthesia care for hip fracture surgery varies widely within and between countries, with general anaesthesia and spinal anaesthesia representing the 2 most common approaches. Limited randomised evidence exists regarding potential short-term or long-term differences in outcomes between patients receiving spinal or general anaesthesia for hip fracture surgery...
November 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/27829785/chronic-pain-in-the-emergency-department-a-pilot-mixed-methods-cross-sectional-study-examining-patient-characteristics-and-reasons-for-presentations
#9
Patricia A Poulin, Jennifer Nelli, Steven Tremblay, Rebecca Small, Myka B Caluyong, Jeffrey Freeman, Heather Romanow, Yehudis Stokes, Tia Carpino, Amanda Carson, Yaadwinder Shergill, Ian G Stiell, Monica Taljaard, Howard Nathan, Catherine E Smyth
Background. Chronic pain (CP) accounts for 10-16% of emergency department (ED) visits, contributing to ED overcrowding and leading to adverse events. Objectives. To describe patients with CP attending the ED and identify factors contributing to their visit. Methods. We used a mixed-method design combining interviews and questionnaires addressing pain, psychological distress, signs of opioid misuse, and disability. Participants were adults who attended the EDs of a large academic tertiary care center for their CP problem...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/27739152/red-blood-cell-transfusion-2016-clinical-practice-guidelines-from-aabb
#10
Aaron A R Tobian, Nancy M Heddle, Theresa L Wiegmann, Jeffrey L Carson
No abstract text is available yet for this article.
October 2016: Transfusion
https://www.readbyqxmd.com/read/27732721/clinical-practice-guidelines-from-the-aabb-red-blood-cell-transfusion-thresholds-and-storage
#11
Jeffrey L Carson, Gordon Guyatt, Nancy M Heddle, Brenda J Grossman, Claudia S Cohn, Mark K Fung, Terry Gernsheimer, John B Holcomb, Lewis J Kaplan, Louis M Katz, Nikki Peterson, Glenn Ramsey, Sunil V Rao, John D Roback, Aryeh Shander, Aaron A R Tobian
Importance: More than 100 million units of blood are collected worldwide each year, yet the indication for red blood cell (RBC) transfusion and the optimal length of RBC storage prior to transfusion are uncertain. Objective: To provide recommendations for the target hemoglobin level for RBC transfusion among hospitalized adult patients who are hemodynamically stable and the length of time RBCs should be stored prior to transfusion. Evidence Review: Reference librarians conducted a literature search for randomized clinical trials (RCTs) evaluating hemoglobin thresholds for RBC transfusion (1950-May 2016) and RBC storage duration (1948-May 2016) without language restrictions...
November 15, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27731885/transfusion-thresholds-and-other-strategies-for-guiding-allogeneic-red-blood-cell-transfusion
#12
REVIEW
Jeffrey L Carson, Simon J Stanworth, Nareg Roubinian, Dean A Fergusson, Darrell Triulzi, Carolyn Doree, Paul C Hebert
BACKGROUND: There is considerable uncertainty regarding the optimal haemoglobin threshold for the use of red blood cell (RBC) transfusions in anaemic patients. Blood is a scarce resource, and in some countries, transfusions are less safe than others because of a lack of testing for viral pathogens. Therefore, reducing the number and volume of transfusions would benefit patients. OBJECTIVES: The aim of this review was to compare 30-day mortality and other clinical outcomes in participants randomized to restrictive versus liberal red blood cell (RBC) transfusion thresholds (triggers) for all conditions...
October 12, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27581603/a-phase-i-study-of-recombinant-r-vaccinia-cea-6d-tricom-and-rfowlpox-cea-6d-tricom-vaccines-with-gm-csf-and-ifn-%C3%AE-2b-in-patients-with-cea-expressing-carcinomas
#13
Megan C Duggan, Caroline Jochems, Renee N Donahue, Jacob Richards, Volodymyr Karpa, Elizabeth Foust, Bonnie Paul, Taylor Brooks, Susheela Tridandapani, Thomas Olencki, Xueliang Pan, Gregory B Lesinski, Jeffrey Schlom, William E Carson Iii
Prime-boost vaccination with recombinant (r) vaccinia(V)-CEA(6D)-TRICOM (triad of co-stimulatory molecules B7.1, ICAM-1 and LFA-3) and rFowlpox(F)-CEA(6D)-TRICOM infect antigen-presenting cells and direct expression of co-stimulatory molecules. We hypothesized that co-administration of vaccine with GM-CSF and interferon alpha (IFN-α) would have efficacy in CEA-expressing cancers. Patients with CEA-expressing cancers received the rV-CEA(6D)-TRICOM vaccine subcutaneously (s.c.) on day 1 followed by GM-CSF s...
November 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27411717/inhibition-of-aak1-kinase-as-a-novel-therapeutic-approach-to-treat-neuropathic-pain
#14
Walter Kostich, Brian D Hamman, Yu-Wen Li, Sreenivasulu Naidu, Kumaran Dandapani, Jianlin Feng, Amy Easton, Clotilde Bourin, Kevin Baker, Jason Allen, Katerina Savelieva, Justin V Louis, Manoj Dokania, Saravanan Elavazhagan, Pradeep Vattikundala, Vivek Sharma, Manish Lal Das, Ganesh Shankar, Anoop Kumar, Vinay K Holenarsipur, Michael Gulianello, Ted Molski, Jeffrey M Brown, Martin Lewis, Yanling Huang, Yifeng Lu, Rick Pieschl, Kevin O'Malley, Jonathan Lippy, Amr Nouraldeen, Thomas H Lanthorn, Guilan Ye, Alan Wilson, Anand Balakrishnan, Rex Denton, James E Grace, Kimberley A Lentz, Kenneth S Santone, Yingzhi Bi, Alan Main, Jon Swaffield, Ken Carson, Sandhya Mandlekar, Reeba K Vikramadithyan, Susheel J Nara, Carolyn Dzierba, Joanne Bronson, John E Macor, Robert Zaczek, Ryan Westphal, Laszlo Kiss, Linda Bristow, Charles M Conway, Brian Zambrowicz, Charles F Albright
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (hot plate, phase I formalin), but a markedly reduced response to persistent pain in phase II formalin. AAK1 knockout mice also failed to develop tactile allodynia following the Chung procedure of spinal nerve ligation (SNL)...
September 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27197761/pseudouridine-synthase-1-deficient-mice-a-model-for-mitochondrial-myopathy-with-sideroblastic-anemia-exhibit-muscle-morphology-and-physiology-alterations
#15
Joshua E Mangum, Justin P Hardee, Dennis K Fix, Melissa J Puppa, Johnathon Elkes, Diego Altomare, Yelena Bykhovskaya, Dean R Campagna, Paul J Schmidt, Anoop K Sendamarai, Hart G W Lidov, Shayne C Barlow, Nathan Fischel-Ghodsian, Mark D Fleming, James A Carson, Jeffrey R Patton
Mitochondrial myopathy with lactic acidosis and sideroblastic anemia (MLASA) is an oxidative phosphorylation disorder, with primary clinical manifestations of myopathic exercise intolerance and a macrocytic sideroblastic anemia. One cause of MLASA is recessive mutations in PUS1, which encodes pseudouridine (Ψ) synthase 1 (Pus1p). Here we describe a mouse model of MLASA due to mutations in PUS1. As expected, certain Ψ modifications were missing in cytoplasmic and mitochondrial tRNAs from Pus1(-/-) animals...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27183603/elastin-derived-peptides-promote-abdominal-aortic-aneurysm-formation-by-modulating-m1-m2-macrophage-polarization
#16
Matthew A Dale, Wanfen Xiong, Jeffrey S Carson, Melissa K Suh, Andrew D Karpisek, Trevor M Meisinger, George P Casale, B Timothy Baxter
Abdominal aortic aneurysm is a dynamic vascular disease characterized by inflammatory cell invasion and extracellular matrix degradation. Damage to elastin in the extracellular matrix results in release of elastin-derived peptides (EDPs), which are chemotactic for inflammatory cells such as monocytes. Their effect on macrophage polarization is less well known. Proinflammatory M1 macrophages initially are recruited to sites of injury, but, if their effects are prolonged, they can lead to chronic inflammation that prevents normal tissue repair...
June 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27112994/red-blood-cell-transfusion-strategies-in-adult-and-pediatric-patients-with-malignancy
#17
REVIEW
Nareg Roubinian, Jeffrey L Carson
Anemia in patients with malignancy is common as a consequence of their disease and treatment. Substantial progress has been made in the management of anemia with red blood cell transfusion in acute conditions, such as bleeding and infection, through the performance of large clinical trials. These trials suggest that transfusion at lower hemoglobin thresholds (restrictive transfusion ∼7-8 g/dL) is safe and in some cases superior to higher transfusion thresholds (liberal transfusion ∼9-10 g/dL). However, additional studies are needed in patients with malignancy to understand best practice in relation to quality of life as well as clinical outcomes...
June 2016: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/27076078/ampk-is-essential-to-balance-glycolysis-and-mitochondrial-metabolism-to-control-t-all-cell-stress-and-survival
#18
Rigel J Kishton, Carson E Barnes, Amanda G Nichols, Sivan Cohen, Valerie A Gerriets, Peter J Siska, Andrew N Macintyre, Pankuri Goraksha-Hicks, Aguirre A de Cubas, Tingyu Liu, Marc O Warmoes, E Dale Abel, Allen Eng Juh Yeoh, Timothy R Gershon, W Kimryn Rathmell, Kristy L Richards, Jason W Locasale, Jeffrey C Rathmell
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with Notch pathway mutations. While both normal activated and leukemic T cells can utilize aerobic glycolysis to support proliferation, it is unclear to what extent these cell populations are metabolically similar and if differences reveal T-ALL vulnerabilities. Here we show that aerobic glycolysis is surprisingly less active in T-ALL cells than proliferating normal T cells and that T-ALL cells are metabolically distinct. Oncogenic Notch promoted glycolysis but also induced metabolic stress that activated 5' AMP-activated kinase (AMPK)...
April 12, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27070726/clinical-features-and-associated-likelihood-of-primary-ciliary-dyskinesia-in-children-and-adolescents
#19
Margaret W Leigh, Thomas W Ferkol, Stephanie D Davis, Hye-Seung Lee, Margaret Rosenfeld, Sharon D Dell, Scott D Sagel, Carlos Milla, Kenneth N Olivier, Kelli M Sullivan, Maimoona A Zariwala, Jessica E Pittman, Adam J Shapiro, Johnny L Carson, Jeffrey Krischer, Milan J Hazucha, Michael R Knowles
RATIONALE: Primary ciliary dyskinesia (PCD), a genetically heterogeneous, recessive disorder of motile cilia, is associated with distinct clinical features. Diagnostic tests, including ultrastructural analysis of cilia, nasal nitric oxide measurements, and molecular testing for mutations in PCD genes, have inherent limitations. OBJECTIVES: To define a statistically valid combination of systematically defined clinical features that strongly associates with PCD in children and adolescents...
August 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/26886470/brief-report-assessment-of-intervention-effects-on-in-vivo-peer-interactions-in-adolescents-with-autism-spectrum-disorder-asd
#20
RANDOMIZED CONTROLLED TRIAL
Bridget K Dolan, Amy V Van Hecke, Audrey M Carson, Jeffrey S Karst, Sheryl Stevens, Kirsten A Schohl, Stephanie Potts, Jenna Kahne, Nina Linneman, Rheanna Remmel, Emily Hummel
This study aimed to evaluate the effectiveness of a randomized controlled trial of a social skills intervention, the Program for the Education and Enrichment of Relational Skills (PEERS: Laugeson et al. in J Autism Dev Disord 39(4): 596-606, 2009), by coding digitally recorded social interactions between adolescent participants with ASD and a typically developing adolescent confederate. Adolescent participants engaged in a 10-min peer interaction at pre- and post-treatment. Interactions were coded using the Contextual Assessment of Social Skills (Ratto et al...
2016: Journal of Autism and Developmental Disorders
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