Fabrício H Holanda, Arlefe N Ribeiro, Brenda L Sánchez-Ortiz, Gisele C de Souza, Swanny F Borges, Adriana M Ferreira, Alexandro C Florentino, Sérgio A Yoshioka, Lienne S Moraes, José Carlos T Carvalho, Irlon M Ferreira
Baicalein (BA) is a flavonoid with wide-ranging pharmacological activity. However, its biological evaluation is hampered by its low solubility in aqueous medium, making forms of incorporation that improve its solubility necessary. In the present study, BA was combined with a solution of silk fibroin protein (SF), a biomaterial used too as a drug carrier, to evaluate the anti-inflammatory potential of this combination, in vivo, in an experimental model, zebrafish (Danio rerio). Baicalein-silk fibroin (BASF) improved the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical scavenging rate (95%) in comparison with BA in solution...
December 22, 2022: Biotechnology Letters