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https://www.readbyqxmd.com/read/28144583/novel-case-of-trevor-s-disease-adult-onset-and-later-recurrence
#1
Amrit S Khalsa, Neil S Kumar, Matthew A Chin, Richard D Lackman
Dysplasia epiphysealis hemimelica (DEH), or Trevor's disease, is an osteocartilaginous epiphyseal overgrowth typically occurring in children. The literature reports 6 adult cases and none describe recurrence requiring additional procedures. We present a new-onset proximal tibial DEH in an adult recurring approximately 3 years after open excision. A 39-year-old female presented with a history of right knee pain, swelling, and instability. Physical examination revealed a firm proximal tibial mass. Computed tomography (CT) imaging showed an exophytic, lobulated, sclerotic mass involving the anterolateral margin of the lateral tibial plateau...
January 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28121384/bioarchaeology-of-adaptation-to-a-marginal-environment-in-bronze-age-western-china
#2
Elizabeth Berger, Hui Wang
OBJECTIVES: This study examines human adaptation to the 4000 BP climate change event, which is said to have increased the marginality of Inner Asian environments. We propose to define "marginal" environments not in relation to a specific economic activity (e.g., agriculture), but in relation to whether humans living there are physiologically stressed. METHODS: Three sites in the Hexi Corridor of Gansu were studied, one from the early and two from the late Bronze Age (N = 125)...
January 25, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28073652/tarsal-tunnel-syndrome-due-to-three-different-types-of-ganglion-during-a-12-year-period-a-case-report
#3
Motohisa Kawakatsu, Toshihiro Ishiko, Masafumi Sumiya
A 52-year-old male complained of numbness and radiating pain affecting the plantar region of his left foot. He was found to have recurrent tarsal tunnel syndrome due to posterior tibial nerve compression by 3 different types of ganglion during a 12-year period. To the best of our knowledge, a similar case has not been documented. At the first operation, flexor retinaculum release and simple excision of an epineural ganglion were performed without injuring the nerve fascicles; however, an intrafascicular ganglion developed approximately 2 years later...
March 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28001453/insulin-resistance-is-associated-with-smaller-cortical-bone-size-in-non-diabetic-men-at-the-age-of-peak-bone-mass
#4
Charlotte Verroken, Hans-Georg Zmierczak, Stefan Goemaere, Jean-Marc Kaufman, Bruno Lapauw
CONTEXT: In type 2 diabetes mellitus, fracture risk is increased despite preserved areal bone mineral density. Although this apparent paradox may in part be explained by insulin resistance affecting bone structure and/or material properties, few studies have investigated the association between insulin resistance and bone geometry. OBJECTIVE: We aimed to explore this association in a cohort of non-diabetic men at the age of peak bone mass. DESIGN, SETTING AND PARTICIPANTS: 996 non-diabetic men aged 25-45 years were recruited in a cross-sectional, population-based sibling-pair study at a university research center...
December 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27966105/habitual-levels-of-higher-but-not-medium-or-low-impact-physical-activity-are-positively-related-to-lower-limb-bone-strength-in-older-women-findings-from-a-population-based-study-using-accelerometers-to-classify-impact-magnitude
#5
K Hannam, K C Deere, A Hartley, U A Al-Sari, E M Clark, W D Fraser, J H Tobias
This study assessed the effect of accelerometry-measured higher impacts resulting from habitual weight-bearing activity on lower limb bone strength in older women. Despite higher impacts being experienced rarely in this population-based cohort, positive associations were observed between higher vertical impacts and lower limb bone size and strength. INTRODUCTION: We investigated whether the benefit of habitual weight-bearing physical activity (PA) for lower limb bone strength in older women is explained by exposure to higher impacts, as previously suggested by observations in younger individuals...
December 13, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27882147/molecular-profiling-of-a-simple-rat-model-of-open-tibial-fractures-with-hematoma-and-periosteum-disruption
#6
Jose Rafael Villafan-Bernal, Lorenzo Franco-De La Torre, Ana Soledad Sandoval-Rodriguez, Juan Armendariz-Borunda, Juan Luis Alcala-Zermeno, Jose Alfonso Cruz-Ramos, Gabriela Lopez-Armas, Blanca Estela Ramirez-Bastidas, Gracia Viviana González-Enríquez, Emerson Armando Collazo-Guzman, Raigam Jafet Martinez-Portilla, Sergio Sánchez-Enríquez
Bone fractures are a worldwide public health concern. Therefore, improving understanding of the bone healing process at a molecular level, which could lead to the discovery of potential therapeutic targets, is important. In the present study, a model of open tibial fractures with hematoma disruption, periosteal rupture and internal fixation in 6-month-old male Wistar rats was established, in order to identify expression patterns of key genes and their protein products throughout the bone healing process. A tibial shaft fracture was produced using the three-point bending technique, the hematoma was drained through a 4-mm incision on the medial aspect of the tibia and the fracture stabilized by inserting a needle into the medullary canal...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27861456/dynamic-stabilization-of-simple-fractures-with-active-plates-delivers-stronger-healing-than-conventional-compression-plating
#7
Michael Bottlang, Stanley Tsai, Emily K Bliven, Brigitte von Rechenberg, Philipp Kindt, Peter Augat, Julia Henschel, Daniel C Fitzpatrick, Steven M Madey
OBJECTIVES: Active plates dynamize a fracture by elastic suspension of screw holes within the plate. We hypothesized that dynamic stabilization with active plates delivers stronger healing relative to standard compression plating. METHODS: Twelve sheep were randomized to receive either a standard compression plate (CP) or an active plate (ACTIVE) for stabilization of an anatomically reduced tibial osteotomy. In the CP group, absolute stabilization was pursued by interfragmentary compression with 6 cortical screws...
February 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27847844/potential-role-of-local-estrogen-in-enhancement-of-fracture-healing-preclinical-study-in-rabbits
#8
Mohammad Tahami, Behrooz Haddad, Armin Abtahian, Ali Hashemi, Amir Aminian, Sujith Konan
BACKGROUND: Effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well documented. However, the efficacy of estrogen treatment on bone healing is not well investigated. The drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. The aim of this study was to investigate the effect of local and systemic administration of estrogen on the fracture healing process. METHODS: Standardized tibial fractures with 4 millimeter gaps were created in twenty four adult male Dutch rabbits...
October 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27843061/vascularised-bone-transfer-history-blood-supply-and-contemporary-problems
#9
REVIEW
David S Sparks, Daniel B Saleh, Warren M Rozen, Dietmar W Hutmacher, Michael A Schuetz, Michael Wagels
BACKGROUND: Since the description of the free fibula flap by Taylor in 1975, many flaps composed of bone have been described. This review documents the history of vascularised bone transfer and reflects on the current understanding of blood supply in an effort to define all clinically described osseous flaps. METHODS: A structured review of MEDLINE and Google Scholar was performed to identify all clinically described bone flaps in humans. Data regarding patterns of vascularity were collected where available from the anatomical literature...
January 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27796050/inflammatory-bowel-disease-in-a-rodent-model-alters-osteocyte-protein-levels-controlling-bone-turnover
#10
Corinne E Metzger, A Narayanan, D C Zawieja, S A Bloomfield
Bone loss is a common comorbidity of inflammatory bowel disease (IBD), leading to elevated fracture risk in these patients. Inflammatory factors associated with IBD cause increased bone resorption and decreased bone formation with multiple factors implicated as instigators of these alterations. In this project, we examined the influence of IBD on osteocytes proteins in male rats (2 months old) divided into two groups: induced gut inflammation via TNBS enema and vehicle control. We examined the prevalence of two pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), an anti-inflammatory cytokine, interleukin-10 (IL-10), the anabolic factor insulin-like growth factor-I (IGF-I), osteoclastogenesis regulators RANKL and OPG, and the bone formation inhibitor sclerostin in osteocytes in three bone compartments 4 weeks after initiation of gut inflammation...
October 31, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27748532/one-year-of-abaloparatide-a-selective-activator-of-the-pth1-receptor-increased-bone-formation-and-bone-mass-in-osteopenic-ovariectomized-rats-without-increasing-bone-resorption
#11
Aurore Varela, Luc Chouinard, Elisabeth Lesage, Susan Y Smith, Gary Hattersley
Abaloparatide is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with 41% homology to PTH(1-34) and 76% homology to PTHrP(1-34). A 12-month treatment study was conducted in osteopenic ovariectomized (OVX) rats to characterize the mechanisms by which abaloparatide increases bone mass. Sprague-Dawley (SD) rats were subjected to OVX or sham surgery at age 6 months and left untreated for 3 months to allow OVX-induced bone loss...
January 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27612440/advanced-quantitative-imaging-and-biomechanical-analyses-of-periosteal-fibers-in-accelerated-bone-growth
#12
Rajeev Chaudhary, Ming-Song Lee, Kuwabo Mubyana, Sarah Duenwald-Kuehl, Lyndsey Johnson, Jarred Kaiser, Ray Vanderby, Kevin W Eliceiri, David T Corr, Matthew S Chin, Wan-Ju Li, Paul J Campagnola, Matthew A Halanski
PURPOSE: The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber alignment at various strains. Additionally, we measured changes in periosteal growth factor transcription. Next we utilized SHG imaging to assess the alignment of the periosteal fibers on the bone both before and after periosteal resection...
November 2016: Bone
https://www.readbyqxmd.com/read/27476374/are-ultrasonographic-findings-like-periosteal-and-tendinous-edema-associated-with-medial-tibial-stress-syndrome-a-case-control-study
#13
Marinus Winters, Paulien Bon, Sascha Bijvoet, Eric W P Bakker, Maarten H Moen
OBJECTIVES: Medial tibial stress syndrome (MTSS) is one of the most common sporting injuries. As of yet, the development of effective therapeutic interventions to treat MTSS is hindered by the fact that its pathology is unknown. Our aim was to explore the pathology of MTSS, by assessing whether the presence of MTSS is related to periosteal, bony or tendinous abnormalities in the lower leg. DESIGN: Case-control study. METHODS: Participants with MTSS and athletic control participants were recruited from the same (high-risk) base population...
July 18, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27357062/activation-of-wnt-signaling-by-mechanical-loading-is-impaired-in-the-bone-of-old-mice
#14
Nilsson Holguin, Michael D Brodt, Matthew J Silva
Aging diminishes bone formation engendered by mechanical loads, but the mechanism for this impairment remains unclear. Because Wnt signaling is required for optimal loading-induced bone formation, we hypothesized that aging impairs the load-induced activation of Wnt signaling. We analyzed dynamic histomorphometry of 5-month-old, 12-month-old, and 22-month-old C57Bl/6JN mice subjected to multiple days of tibial compression and corroborated an age-related decline in the periosteal loading response on day 5. Similarly, 1 day of loading increased periosteal and endocortical bone formation in young-adult (5-month-old) mice, but old (22-month-old) mice were unresponsive...
December 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27143111/trabecular-and-cortical-bone-deficits-are-present-in-children-and-adolescents-with-cystic-fibrosis
#15
Andrea Kelly, Joan Schall, Virginia A Stallings, Babette S Zemel
Osteopenia and increased fracture rates are well-recognized in adults with CF, but neither the specific contributions of cortical and trabecular bone deficits to bone fragility nor their presence in youth with CF are well-characterized. This study sought to characterize cortical and trabecular volumetric bone mineral density (vBMD), geometry, and biomechanical competence in children with CF and determine their relationship to growth, body composition, and disease severity. Peripheral quantitative computerized tomography (pQCT) measures of total, cortical, and trabecular vBMD, cortical, muscle, and fat cross-sectional areas (CSA), periosteal and endosteal circumferences, and the polar unweighted section modulus (Zp) of the tibia were converted to age- and tibial length-adjusted Z-scores in 97 CF and 199 healthy children (aged 8-21y)...
September 2016: Bone
https://www.readbyqxmd.com/read/27142755/scintigraphic-evaluation-of-the-osteoblastic-activity-of-rabbit-tibial-defects-after-hyaff11-membrane-application
#16
Musa Uğur Mermerkaya, Mahmut Nedim Doral, Fatih Karaaslan, Gazi Huri, Seyhan Karacavuş, Burak Kaymaz, Erkan Alkan
BACKGROUND: An unfavorable condition for bone healing is the presence of bone defects. Under such conditions, a material can play a role to cover fractured or defective bone. Technological advances now allow for the use of such material. Hyalonect(®) (Fidia Advanced Biopolymers SLR, Italy), a novel membrane comprising knitted fibers of esterified hyaluronan (HYAFF11) can be used to cover fractured or grafted bone and can also serve as a scaffold to keep osteoprogenitor cells in place...
May 3, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27124031/the-periosteal-autografts-transplantation-for-cartilage-defects-of-the-hip-in-older-children-with-developmental-dysplasia-as-an-adjunctive-procedure
#17
Ming-Hua Du, Yu Ding, Xian Shi, Rui-Jiang Xu
Cartilage lesions are at a high prevalence in dysplastic hips and may relate to arthritic changes and hip joint dysfunction. To date, the effectiveness of repair of articular cartilage defects in the dysplastic hips has not yet been thoroughly evaluated. Here we retrospectively reviewed the effects of acetabuloplasty procedures with/without concomitant autologous tibial periosteal transplantation (ATPT) for articular cartilage defects of the hip in older children with developmental dysplasia of the hip (DDH)...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27120898/-surprisingly-old-skeleton-found-at-bornheim-uedorf-rhein-sieg-kreis-research-results-in-forensic-medicine-anthropology-and-archaeology
#18
Stephanie Zesch, Elke Doberentz, Michael Schmauder, Wilfried Rosendahl, Burkhard Madea
On April 15th 2014, human skeletal remains were found during digging activities for constructing a new building at Bornheim-Uedorf (Rhein-Sieg-Kreis) near the river Rhine (about 20 meters) in a pit measuring 10 by 10 meters and having a depth of about 150 cm. The skeletal remains were preserved quite well considering the fact that they were located so near to the Rhine, although several skeletal parts were missing. The preserved skeletal remains comprised some skull fragments (including two ear bones of the right side), right scapula, both humeri, left ulna, left radius, left metacarpal bone 2, right metacarpal bones 1, 3 and 4, rib fragments, three thoracic vertebrae, all lumbar vertebrae, one sacral vertebra, pelvis fragments, left femur, proximal part of the left tibial diaphysis, right tibia and diaphysis of both fibulae...
March 2016: Archiv Für Kriminologie
https://www.readbyqxmd.com/read/27077590/medial-collateral-ligament-complex-of-the-ankle-mr-imaging-anatomy-and-findings-in-medial-instability
#19
REVIEW
Bernard Mengiardi, Clinton Pinto, Marco Zanetti
Ankle ligament injuries are among the most common injuries in sports and recreational activities. Injuries of the medial collateral ligament or deltoid ligament complex account for ∼ 15% of ligamentous ankle trauma. They are usually associated with injuries of the lateral collateral ligaments and the tibiofibular syndesmosis, as well as malleolar fractures. The deltoid ligament complex consists of a superficial and a deep layer. The three main components of the superficial layer are the tibionavicular, tibiospring, and tibiocalcaneal ligaments...
February 2016: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/27046087/increased-density-and-periosteal-expansion-of-the-tibia-in-young-adult-men-following-short-term-arduous-training
#20
Rachel M Izard, William D Fraser, Charles Negus, Craig Sale, Julie P Greeves
PURPOSE: Few human studies have reported early structural adaptations of bone to weight-bearing exercise, which provide a greater contribution to improved bone strength than increased density. This prospective study examined site- and regional-specific adaptations of the tibia during arduous training in a cohort of male military (infantry) recruits to better understand how bone responds in vivo to mechanical loading. METHODS: Tibial bone density and geometry were measured in 90 British Army male recruits (ages 21±3years, height: 1...
July 2016: Bone
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