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tibial periostitis

Aurore Varela, Luc Chouinard, Elisabeth Lesage, Susan Y Smith, Gary Hattersley
Abaloparatide is a novel 34-amino acid peptide selected to be a potent and selective activator of the parathyroid hormone receptor (PTH1R) signaling pathway with 41% homology to PTH(1-34) and 76% homology to PTHrP(1-34). A 12-month treatment study was conducted in osteopenic ovariectomized (OVX) rats to characterize the mechanisms by which abaloparatide increases bone mass. Sprague-Dawley (SD) rats were subjected to OVX or sham surgery at age 6 months and left untreated for 3 months to allow OVX-induced bone loss...
October 17, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Rajeev Chaudhary, Ming-Song Lee, Kuwabo Mubyana, Sarah Duenwald-Kuehl, Lyndsey Johnson, Jarred Kaiser, Ray Vanderby, Kevin W Eliceiri, David T Corr, Matthew S Chin, Wan-Ju Li, Paul J Campagnola, Matthew A Halanski
PURPOSE: The accepted mechanism explaining the accelerated growth following periosteal resection is that the periosteum serves as a mechanical restraint to restrict physeal growth. To test the veracity of this mechanism we first utilized Second Harmonic Generation (SHG) imaging to measure differences of periosteal fiber alignment at various strains. Additionally, we measured changes in periosteal growth factor transcription. Next we utilized SHG imaging to assess the alignment of the periosteal fibers on the bone both before and after periosteal resection...
November 2016: Bone
Marinus Winters, Paulien Bon, Sascha Bijvoet, Eric W P Bakker, Maarten H Moen
OBJECTIVES: Medial tibial stress syndrome (MTSS) is one of the most common sporting injuries. As of yet, the development of effective therapeutic interventions to treat MTSS is hindered by the fact that its pathology is unknown. Our aim was to explore the pathology of MTSS, by assessing whether the presence of MTSS is related to periosteal, bony or tendinous abnormalities in the lower leg. DESIGN: Case-control study. METHODS: Participants with MTSS and athletic control participants were recruited from the same (high-risk) base population...
July 18, 2016: Journal of Science and Medicine in Sport
Nilsson Holguin, Michael D Brodt, Matthew J Silva
Aging diminishes bone formation engendered by mechanical loads, but the mechanism for this impairment remains unclear. Because Wnt signaling is required for optimal loading-induced bone formation, we hypothesized that aging impairs the load-induced activation of Wnt signaling. We analyzed dynamic histomorphometry of 5-, 12- and 22-month C57Bl/6JN mice subjected to multiple days of tibial compression and corroborated an age-related decline in the periosteal loading response on day 5. Similarly, 1 day of loading increased periosteal and endocortical bone formation in young-adult (5-mo) mice, but old (22-mo) mice were unresponsive...
June 30, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Andrea Kelly, Joan Schall, Virginia A Stallings, Babette S Zemel
Osteopenia and increased fracture rates are well-recognized in adults with CF, but neither the specific contributions of cortical and trabecular bone deficits to bone fragility nor their presence in youth with CF are well-characterized. This study sought to characterize cortical and trabecular volumetric bone mineral density (vBMD), geometry, and biomechanical competence in children with CF and determine their relationship to growth, body composition, and disease severity. Peripheral quantitative computerized tomography (pQCT) measures of total, cortical, and trabecular vBMD, cortical, muscle, and fat cross-sectional areas (CSA), periosteal and endosteal circumferences, and the polar unweighted section modulus (Zp) of the tibia were converted to age- and tibial length-adjusted Z-scores in 97 CF and 199 healthy children (aged 8-21y)...
September 2016: Bone
Musa Uğur Mermerkaya, Mahmut Nedim Doral, Fatih Karaaslan, Gazi Huri, Seyhan Karacavuş, Burak Kaymaz, Erkan Alkan
BACKGROUND: An unfavorable condition for bone healing is the presence of bone defects. Under such conditions, a material can play a role to cover fractured or defective bone. Technological advances now allow for the use of such material. Hyalonect(®) (Fidia Advanced Biopolymers SLR, Italy), a novel membrane comprising knitted fibers of esterified hyaluronan (HYAFF11) can be used to cover fractured or grafted bone and can also serve as a scaffold to keep osteoprogenitor cells in place...
2016: Journal of Orthopaedic Surgery and Research
Ming-Hua Du, Yu Ding, Xian Shi, Rui-Jiang Xu
Cartilage lesions are at a high prevalence in dysplastic hips and may relate to arthritic changes and hip joint dysfunction. To date, the effectiveness of repair of articular cartilage defects in the dysplastic hips has not yet been thoroughly evaluated. Here we retrospectively reviewed the effects of acetabuloplasty procedures with/without concomitant autologous tibial periosteal transplantation (ATPT) for articular cartilage defects of the hip in older children with developmental dysplasia of the hip (DDH)...
April 2016: Medicine (Baltimore)
Stephanie Zesch, Elke Doberentz, Michael Schmauder, Wilfried Rosendahl, Burkhard Madea
On April 15th 2014, human skeletal remains were found during digging activities for constructing a new building at Bornheim-Uedorf (Rhein-Sieg-Kreis) near the river Rhine (about 20 meters) in a pit measuring 10 by 10 meters and having a depth of about 150 cm. The skeletal remains were preserved quite well considering the fact that they were located so near to the Rhine, although several skeletal parts were missing. The preserved skeletal remains comprised some skull fragments (including two ear bones of the right side), right scapula, both humeri, left ulna, left radius, left metacarpal bone 2, right metacarpal bones 1, 3 and 4, rib fragments, three thoracic vertebrae, all lumbar vertebrae, one sacral vertebra, pelvis fragments, left femur, proximal part of the left tibial diaphysis, right tibia and diaphysis of both fibulae...
March 2016: Archiv Für Kriminologie
Bernard Mengiardi, Clinton Pinto, Marco Zanetti
Ankle ligament injuries are among the most common injuries in sports and recreational activities. Injuries of the medial collateral ligament or deltoid ligament complex account for ∼ 15% of ligamentous ankle trauma. They are usually associated with injuries of the lateral collateral ligaments and the tibiofibular syndesmosis, as well as malleolar fractures. The deltoid ligament complex consists of a superficial and a deep layer. The three main components of the superficial layer are the tibionavicular, tibiospring, and tibiocalcaneal ligaments...
February 2016: Seminars in Musculoskeletal Radiology
Rachel M Izard, William D Fraser, Charles Negus, Craig Sale, Julie P Greeves
PURPOSE: Few human studies have reported early structural adaptations of bone to weight-bearing exercise, which provide a greater contribution to improved bone strength than increased density. This prospective study examined site- and regional-specific adaptations of the tibia during arduous training in a cohort of male military (infantry) recruits to better understand how bone responds in vivo to mechanical loading. METHODS: Tibial bone density and geometry were measured in 90 British Army male recruits (ages 21±3years, height: 1...
July 2016: Bone
Annette I Birkhold, Hajar Razi, Georg N Duda, Richard Weinkamer, Sara Checa, Bettina M Willie
Dynamic processes modify bone micro-structure to adapt to external loading and avoid mechanical failure. Age-related cortical bone loss is thought to occur because of increased endocortical resorption and reduced periosteal formation. Differences in the (re)modeling response to loading on both surfaces, however, are poorly understood. Combining in-vivo tibial loading, in-vivo micro-tomography and finite element analysis, remodeling in C57Bl/6J mice of three ages (10, 26, 78 week old) was analyzed to identify differences in mechano-responsiveness and its age-related change on the two cortical surfaces...
2016: Scientific Reports
T L Binkley, B L Specker
OBJECTIVE: Effects of time in moderate to vigorous physical activity (MVPA) and sitting (SIT) on bone were tested, hypothesizing that high MVPA would be positively associated with bone size and strength, offset effects of high SIT, and be mediated by lean mass. METHODS: 155 children (79 male, 58 pubertal), 6-20 years (10.2±3.5 yr) were measured by dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). MVPA and SIT were measured by 7-day activity recall...
March 2016: Journal of Musculoskeletal & Neuronal Interactions
Arjun Ballal, H Ravindranath Rai, Siddharth M Shetty, Lawrence John Mathias, Vikram Shetty, Ashwin Shetty
INTRODUCTION: Managing pilon fractures is still a great challenge for surgeons in terms of reduction and fixation. The soft tissue anatomy and the bony configuration, results in angular and rotational instability and other bony and soft tissue complications. AIM: To evaluate the results of minimally invasive plate osteosynthesis using locking plates in management of fractures of tibial pilon in terms of radiological fracture union, restoration of ankle function and complications...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Rashida F Vasanwala, Anish Sanghrajka, Nicholas J Bishop, Wolfgang Högler
Long-term bisphosphonate (BP) therapy in adults with osteoporosis is associated with atypical femoral fractures, caused by increased material bone density and prolonged suppression of bone remodeling which may reduce fracture toughness. In children with osteogenesis imperfecta (OI), long-term intravenous BP therapy improves bone structure and mass without further increasing the already hypermineralized bone matrix, and is generally regarded as safe. Here we report a teenage girl with OI type IV, who was started on cyclical intravenous pamidronate therapy at age 6 years because of recurrent fractures...
July 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Yusuhn Kang, Sung Hwan Hong, Hye Jin Yoo, Ja-Young Choi, Jin Kyun Park, Jina Park, Heung Sik Kang
OBJECTIVE: The purpose of this study is to describe MRI findings of muscle involvement in patients with polyarteritis nodosa (PAN), with an emphasis on the contrast enhancement characteristics. MATERIALS AND METHODS: MRI studies of eight patients with PAN were retrospectively reviewed (four male and four female patients; mean age at presentation, 34.3 years; age range, 7-64 years). MR images were evaluated focusing on the following features: affected structures (muscle, fascia, or periosteum), lesion signal intensity and characteristics on T1-and T2-weighted images, and contrast enhancement patterns...
February 2016: AJR. American Journal of Roentgenology
Yulong Ni, Shunhong Gao, Jingyu Zhang, Huishuang Dong, Yunpeng Zhang, Jiansong Fu
OBJECTIVE: To investigate the effectiveness of tibial periosteal flap pedicled with intermuscular branch of posterior tibial vessels combined with autologous bone graft in the treatment of tibial bone defects. METHODS: Between January 2007 and December 2013, 19 cases of traumatic tibia bone and soft tissue defects were treated. There were 14 males and 5 females, aged from 18 to 49 years (mean, 28 years). The tibial fracture site located at the middle tibia in 6 cases and at the distal tibia in 13 cases...
October 2015: Chinese Journal of Reparative and Reconstructive Surgery
D A Popkov, N A Kononovich, E R Mingazov, R B Shutov, D Barbier
BACKGROUND: Intramedullary transphyseal elastic osteosynthesis is used in children for the diseases accompanied by the reduced strength properties of bone tissue, and primarily for osteogenesis imperfecta. OBJECTIVE: The purpose of the experimental study was to investigate tibial growth under the conditions of transphyseal counter-directed insertion of elastic rods without bone integrity breaking, under transverse fracture modeling, as well as under combining transphyseal reinforcement and subperiosteal positioning the titanium mesh with the elastic rods intervolved in it...
2015: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Matthew A Halanski, Tugrul Yildirim, Rajeev Chaudhary, Matthew S Chin, Ellen Leiferman
BACKGROUND: Disruption of the periosteum has been used to explain overgrowth after long bone fractures. Clinically, various periosteal procedures have been reported to accelerate growth with varied results. Differences between procedures and study populations, in these prior studies, make drawing conclusions regarding their effectiveness difficult. QUESTIONS/PURPOSES: The purpose of this study was to (1) determine if all reported periosteal procedures accelerate growth and increase the length of bones; (2) study the relative duration of these growth-accelerating effects at two time points; and (3) identify the periosteal procedure that results in the most growth...
April 2016: Clinical Orthopaedics and related Research
Charlotte Verroken, Hans-Georg Zmierczak, Stefan Goemaere, Jean-Marc Kaufman, Bruno Lapauw
Jumping mechanography has been developed to estimate maximum voluntary muscle forces. This study assessed associations of jumping mechanography-derived force and power measurements with tibial cortical bone geometry, compared to other estimates of muscle mass, size, and function. Healthy men (n = 181; 25-45 years) were recruited in a cross-sectional, population-based sibling-pair study. Muscle parameters include isokinetic peak torque of the quadriceps, DXA-derived leg lean mass, mechanography-derived peak jump force and power, and pQCT-derived mid-tibial (66 %) muscle cross-sectional area (CSA)...
May 2016: Calcified Tissue International
Paula Diaz-Gallardo, Jorge Knörr, I Vega-Encina, Pablo S Corona, Sergi Barrera-Ochoa, Alfonso Rodriguez-Baeza, Vasco V Mascarenhas, Francisco Soldado
Several types of vascularized periosteal flaps have recently been described for the treatment or prevention of complex non-union in pediatric patients. Among them, a vascularized tibial periosteal graft (VTPG), supplied by the anterior tibial vessels (ATV), has been used successfully as a pedicled flap in a few patients. The purpose of the study is to describe the periosteal branches of the ATV, as well as the cutaneous and muscular branches by means of an anatomical study. In addition, to report on the use of VTPG as a free flap with a monitoring skin island in a clinical case...
December 1, 2015: Microsurgery
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