Elliot H Lee, Jung-Eun Park, Lizaveta Gotina, Young-Eun Han, Ambily Nath Indu Viswanath, Seonguk Yoo, Bongjin Moon, Jin-Young Hwang, Woo Kyu Park, Yoonjeong Cho, Chiman Song, Sun-Joon Min, Eun Mi Hwang, Hyunbeom Lee, Ae Nim Pae, Eun Joo Roh, Soo-Jin Oh
TREK-1 (TWIK-related potassium channel-1) is a subunit of the two-pore domain potassium (K2p) channel and is widely expressed in the brain. TREK-1 knockout mice were shown to have antidepressant-like effects, providing evidence for the channel's potential as a therapeutic target. However, currently there is no good pharmacological inhibitor specifically targeting TREK-1 containing K2p channels that also displays similar antidepressant-like effects. Here, we sought to find selective and potent inhibitors for TREK-1 related dimers both in vitro and in vivo...
July 14, 2023: Biomedicine & Pharmacotherapy