Christopher Nelke, Thomas Müntefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B Schroeter, Helena Block, Corinna Preuße, Alexander P E Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E Lundberg, Werner Stenzel, Sven G Meuth, Tobias Ruck
K2P 2.1 (TREK1), a two-pore domain potassium channel, has emerged as regulator of leukocyte transmigration into the central nervous system. In the context of skeletal muscle, immune cell infiltration constitutes the pathogenic hallmark of idiopathic inflammatory myopathies (IIMs). However, the underlying mechanisms remain to be elucidated. In this study, we investigated the role of K2P 2.1 in the autoimmune response of IIMs. We detected K2P 2.1 expression in primary skeletal muscle and endothelial cells of murine and human origin...
November 5, 2023: Journal of Autoimmunity