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https://www.readbyqxmd.com/read/28341653/locomotion-behavior-is-affected-by-the-g%C3%AE-s-pathway-and-the-two-pore-domain-k-channel-twk-7-interacting-in-gabaergic-motor-neurons-in-caenorhabditis-elegans
#1
Dieter-Christian Gottschling, Frank Döring, Kai Lüersen
Adjusting the efficiency of movement in response to environmental cues is an essential integrative characteristic of adaptive locomotion behavior across species. However, the modulatory molecules and the pathways involved are largely unknown. Recently, we demonstrated that in Caenorhabditis elegans, a loss of function of the two-pore-domain potassium (K2P) channel TWK-7 causes a fast, coordinated, persistent forward crawling behavior in which five central aspects of stimulated locomotion -- velocity, direction, wave parameters, duration and straightness -- are affected...
March 24, 2017: Genetics
https://www.readbyqxmd.com/read/28341634/contribution-of-two-pore-potassium-channels-to-cardiac-ventricular-action-potential-revealed-using-human-ipsc-derived-cardiomyocytes
#2
Sam Chai, Xiaoping Wan, Drew M Nassal, Haiyan Liu, Christine S Moravec, Angelina Ramirez-Navarro, Isabelle Deschenes
Two pore potassium channels (K2p) have been described in modulating background conductance as leak channels in different physiological systems. In the heart, the expression of K2p channels is heterogeneous with equivocation regarding their functional role. Our objective was to determine the K2p expression profile and their physiological and pathophysiological contribution to cardiac electrophysiology. Induced pluripotent stem cells (iPSC) cells generated from humans were differentiated into cardiomyocytes (iPSC-CM)...
March 24, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28328397/age-dependent-diastolic-heart-failure-in-an-in-vivo-drosophila-model
#3
Matthew P Klassen, Christian J Peters, Shiwei Zhou, Hannah H Williams, Lily Yeh Jan, Yuh Nung Jan
While the signals and complexes that coordinate the heartbeat are well established, how the heart maintains its electromechanical rhythm over a lifetime remains an open question with significant implications to human health. Reasoning that this homeostatic challenge confronts all pulsatile organs, we developed a high resolution imaging and analysis toolset for measuring cardiac function in intact, unanesthetized Drosophila melanogaster. We demonstrate that, as in humans, normal aging primarily manifests as defects in relaxation (diastole) while preserving contractile performance...
March 22, 2017: ELife
https://www.readbyqxmd.com/read/28290215/genetic-assessment-of-leech-species-from-yak-bos-grunniens-in-the-tract-of-northeast-india
#4
Nilkantha Chatterjee, Bishal Dhar, Debasis Bhattarcharya, Sourabh Deori, Juwar Doley, Joken Bam, Pranab J Das, Asit K Bera, Sitangshu M Deb, Ningthoujam Neelima Devi, Rajesh Paul, Sorokhaibam Malvika, Sankar Kumar Ghosh
Yak is an iconic symbol of Tibet and high altitudes of Northeast India. It is highly cherished for milk, meat, and skin. However, yaks suffer drastic change in milk production, weight loss, etc, when infested by parasites. Among them, infestation by leeches is a serious problem in the Himalayan belt of Northeast India. The parasite feeds on blood externally or from body orifices, like nasopharynx, oral, rectum, etc. But there has been limited data about the leech species infesting the yak in that region because of the difficulties in morphological identification due to plasticity of the body, changes in shape, and surface structure and thus, warrants for the molecular characterization of leech...
March 14, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28278695/dna-barcoding-and-genetic-diversity-analyses-of-fishes-of-kaladan-river-of-indo-myanmar-biodiversity-hotspot
#5
Anindya Sundar Barman, Mamta Singh, Pramod Kumar Pandey
Species are considered as a fundamental unit of biodiversity. Therefore, the prerequisite for biodiversity management and conservation is to know the number of species one is dealing with. Consequently, the need of the present study was conceptualized, which dealt with the comprehensive molecular appraisal of Kaladan's Fish fauna. A total of 291 specimens representing 49 species, 28 genera, 11 families, and 4 orders, were collected from 11 sampling stations situated along the main Kaladan River and its four major tributaries, i...
February 16, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28278688/molecular-phylogenetic-analysis-of-genus-osteobrama-heckel-1843-and-discovery-of-osteobrama-serrata-sp-nov-from-north-east-india
#6
Mahender Singh, Rashmi Verma, Rameshori Yumnam, Waikhom Vishwanath
Genus Osteobrama Heckel is characterized by strongly compressed, fairly deep body with abdominal edge sharp and trenchant entirely or from the pelvic fin base to vent; anal fin long with 14-36 rays, of which 11-13 are branched rays. The fishes of this genus are distributed in Pakistan, India, Bangladesh, Burma, and Yunnan (China). Present study involve six Osteobrama species viz. O. belangeri, O. cotio, O. cunma, O. feae, O. serrata sp. nov., and O. vigorsii. Out of the 655 positions analyzed in the COI sequence dataset, 171 positions (26...
March 2, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28258154/sodium-leak-through-k2p-potassium-channels-and-cardiac-arrhythmia-an-emerging-theme
#7
Steve An Goldstein
No abstract text is available yet for this article.
March 3, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28242754/sodium-permeable-and-hypersensitive-trek-1-channels-cause-ventricular-tachycardia
#8
Niels Decher, Beatriz Ortiz-Bonnin, Corinna Friedrich, Marcus Schewe, Aytug K Kiper, Susanne Rinné, Gunnar Seemann, Rémi Peyronnet, Sven Zumhagen, Daniel Bustos, Jens Kockskämper, Peter Kohl, Steffen Just, Wendy González, Thomas Baukrowitz, Birgit Stallmeyer, Eric Schulze-Bahr
In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch-activated K2P potassium channel TREK-1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability to TREK-1. In addition, mutant channels exhibit a hypersensitivity to stretch-activation, suggesting that the selectivity filter is directly involved in stretch-induced activation and desensitization. Increased sodium permeability and stretch-sensitivity of mutant TREK-1 channels may trigger arrhythmias in areas of the heart with high physical strain such as the RVOT We present a pharmacological strategy to rescue the selectivity defect of the TREK-1 pore...
February 27, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28192611/deficiency-of-trek-1-potassium-channel-exacerbates-secondary-injury-following-spinal-cord-injury-in-mice
#9
Yongkang Fang, Xiaojiang Huang, Yue Wan, Hao Tian, Yeye Tian, Wei Wang, Suiqiang Zhu, Minjie Xie
Spinal cord injury (SCI) involves complex pathological process which can be complicated by secondary injury. TREK-1 is a member of the two-pore domain potassium (K2P) channel family, which can be modulated by a number of physiological and pathological stimuli. Recent studies suggest that TREK-1 plays an active role in depression, pain and neuroprotection. However, its role in the pathological process after SCI remains unclear. In this study, we tested the expression and function of TREK-1 in spinal cord of mice after traumatic SCI...
February 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28104086/identification-of-triplophysa-species-from-the-qinghai-tibetan-plateau-qtp-and-its-adjacent-regions-through-dna-barcodes
#10
Jiuxuan Li, Ying Wang, Huifang Jin, Wujiao Li, Chaochao Yan, Pengfei Yan, Xiuyue Zhang, Shunping He, Zhaobin Song
The genus Triplophysa is the largest and most difficult to identity morphologically fish group of superfamily Cobitoidea with 140 currently valid species, and is mainly distributed in the Qinghai-Tibetan Plateau (QTP) and adjacent regions. Most species within this genus possess highly similar morphological characteristics for adaption to the highland environment and are very difficult to be identified only based on morphology. The traditional species identification, mainly based on external morphological diagnostic characters, leads to inconsistent results in many cases...
March 20, 2017: Gene
https://www.readbyqxmd.com/read/28062596/prediction-of-the-clinical-standardized-uptake-value-ratio-in-amyloid-pet-imaging-using-a-biomathematical-modeling-approach-towards-the-efficient-development-of-a-radioligand
#11
Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
OBJECTIVE: Our study aimed to develop a method to mathematically predict the kinetic parameters K1, k2 and BPND of amyloid PET tracers, and finally obtain standardized uptake value ratio (SUVR) values from predicted time-activity curves (TACs) of target and reference regions. METHODS: Ten clinically applied amyloid PET radioligands, (11)C-PIB, (11)C-BF-227, (11)C-AZD2184, (11)C-SB-13, (18)F-FACT, (18)F-Florbetapir, (18)F-Florbetaben, (18)F-Flutemetamol, (18)F-FDDNP and (18)F-AZD4694, were investigated...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28044459/species-level-identification-of-the-blowfly-chrysomya-megacephala-and-other-diptera-in-china-by-dna-barcoding
#12
Deyi Qiu, Charles E Cook, Qiaoyun Yue, Jia Hu, Xiaoya Wei, Jian Chen, Dexing Liu, Keliang Wu
The blowfly Chrysomya megacephala, or oriental latrine fly, is the most common human-associated fly of the oriental and Australasian regions. Chrysomya megacephala is of particular interest for its use in forensic entomology and because it is a disease vector. The larvae are economically important as feed for livestock and in traditional Chinese medicine. Identification of adults is straightforward, but larvae and fragments of adults are difficult to identify. We collected C. megacephala, its allies Chrysomya pinguis and Protophormia terraenovae, as well as flies from 11 other species from 52 locations around China, then sequenced 658 base pairs of the COI barcode region from 645 flies of all 14 species, including 208 C...
February 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/27994958/feasibility-of-nuclear-ribosomal-region-its1-over-its2-in-barcoding-taxonomically-challenging-genera-of-subtribe-cassiinae-fabaceae
#13
Priyanka Mishra, Amit Kumar, Vereena Rodrigues, Ashutosh K Shukla, Velusamy Sundaresan
PREMISE OF THE STUDY: The internal transcribed spacer (ITS) region is situated between 18S and 26S in a polycistronic rRNA precursor transcript. It had been proved to be the most commonly sequenced region across plant species to resolve phylogenetic relationships ranging from shallow to deep taxonomic levels. Despite several taxonomical revisions in Cassiinae, a stable phylogeny remains elusive at the molecular level, particularly concerning the delineation of species in the genera Cassia, Senna and Chamaecrista...
2016: PeerJ
https://www.readbyqxmd.com/read/27933000/in-depth-study-of-the-interaction-sensitivity-and-gating-modulation-by-pufas-on-k-channels-interaction-and-new-targets
#14
REVIEW
Cristina Moreno, Alicia de la Cruz, Carmen Valenzuela
Voltage gated potassium channels (KV) are membrane proteins that allow selective flow of K(+) ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated fatty acids (PUFAs) enhance or decrease the activity of several cardiac KV channels. PUFAs-dependent modulation of potassium ion channels has been reported to be cardioprotective. However, the precise cellular mechanism underlying the cardiovascular benefits remained unclear in part because new PUFAs targets and signaling pathways continue being discovered...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27871204/dna-barcoding-of-a-colonial-ascidian-lissoclinum-fragile-van-name-1902
#15
Jaffarali H Abdul, Soban Akram, Kaleem M L Arshan
Ascidians (tunicates) are marine benthic organisms possessing various pharmacological activities, including anti-oxidant, anti-tumour, antimicrobial, etc. They also play a key role as model organisms to study various neurobehavioral disorders. Ascidian diversity is reportedly less in India due to lack of taxonomists as well as the limitations in morphology based taxonomy. Molecular taxonomy, comprising the sequencing of cytochrome c oxidase 1 gene (barcode region) otherwise known as DNA barcoding reduces these bottlenecks...
November 22, 2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/27811749/use-of-dna-barcoding-to-distinguish-the-malaria-vector-anopheles-neivai-in-colombia
#16
Andrés López-Rubio, Juan Suaza-Vasco, Paula L Marcet, Natalia Ruíz-Molina, Lorenzo Cáceres, Charles Porter, Sandra Uribe
A reference 535 bp barcode sequence from a fragment of the mitochondrial gene cytochrome oxidase I (COI), acquired from specimens of An. neivai Howard, Dyar & Knab, 1913 from its type locality in Panama, was used as a tool for distinguishing this species from others in the subgenus Kerteszia. Comparisons with corresponding regions of COI between An. neivai and other species in the subgenus (An. bellator Dyar & Knab 1906, An. homunculus Komp 1937, An cruzii Dyar & Knab, 1908 and An. laneanus Corrêa & Cerqueira, 1944) produced K2P genetic distances of 8...
October 17, 2016: Zootaxa
https://www.readbyqxmd.com/read/27805811/selective-small-molecule-activators-of-trek-2-channels-stimulate-drg-c-fiber-nociceptor-k2p-currents-and-limit-calcium-influx
#17
Prassana K Dadi, Nicholas Catin Vierra, Emily L Days, Matthew Dickerson, Paige N Vinson, C David Weaver, David A Jacobson
The two-pore-domain potassium (K2P) channel TREK-2 serves to modulate plasma membrane potential in dorsal root ganglia c-fiber nociceptors, which tunes electrical excitability and nociception. Thus, TREK-2 activators are considered a potential therapeutic target for treating pain; however, there are currently no selective pharmacological tools for TREK-2 channels. Here we report the identification of the first TREK-2 selective activators using a high-throughput fluorescence-based thallium (Tl(+)) flux screen (HTS)...
November 2, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27790056/two-pore-domain-potassium-channels-in-astrocytes
#18
REVIEW
Kanghyun Ryoo, Jae-Yong Park
Two-pore domain potassium (K2P) channels have a distinct structure and channel properties, and are involved in a background K(+) current. The 15 members of the K2P channels are identified and classified into six subfamilies on the basis of their sequence similarities. The activity of the channels is dynamically regulated by various physical, chemical, and biological effectors. The channels are expressed in a wide variety of tissues in mammals in an isoform specific manner, and play various roles in many physiological and pathophysiological conditions...
October 2016: Experimental Neurobiology
https://www.readbyqxmd.com/read/27743426/14-3-3-proteins-regulate-k2p-5-1-surface-expression-on-t-lymphocytes
#19
Juncal Fernández-Orth, Petra Ehling, Tobias Ruck, Susann Pankratz, Majella-Sophie Hofmann, Peter Landgraf, Daniela C Dieterich, Karl-Heinz Smalla, Thilo Kähne, Guiscard Seebohm, Thomas Budde, Heinz Wiendl, Stefan Bittner, Sven G Meuth
K2P 5.1 channels (also called TASK-2 or Kcnk5) have already been shown to be relevant in the pathophysiology of autoimmune disease because they are known to be upregulated on peripheral and central T lymphocytes of multiple sclerosis (MS) patients. Moreover, overexpression of K2P 5.1 channels in vitro provokes enhanced T-cell effector functions. However, the molecular mechanisms regulating intracellular K2P 5.1 channel trafficking are unknown so far. Thus, the aim of the study is to elucidate the trafficking of K2P 5...
January 2017: Traffic
https://www.readbyqxmd.com/read/27742566/atrial-fibrillation-therapeutic-potential-of-atrial-k-channel-blockers
#20
REVIEW
Ursula Ravens, Katja E Odening
Despite the epidemiological scale of atrial fibrillation, current treatment strategies are of limited efficacy and safety. Ideally, novel drugs should specifically correct the pathophysiological mechanisms responsible for atrial fibrillation with no other cardiac or extracardiac actions. Atrial-selective drugs are directed toward cellular targets with sufficiently different characteristics in atria and ventricles to modify only atrial function. Several potassium (K(+)) channels with either predominant expression in atria or distinct electrophysiological properties in atria and ventricles can serve as atrial-selective drug targets...
October 12, 2016: Pharmacology & Therapeutics
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