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https://www.readbyqxmd.com/read/29327637/evidence-of-shallow-mitochondrial-divergence-in-the-slender-armorhead-pentaceros-wheeleri-pisces-pentacerotidae-from-the-emperor-seamount-chain
#1
Seung Eun Bae, Hanna Kim, Seok-Gwan Choi, Jin-Koo Kim
Competitive overexploitation of the slender armorhead, Pentaceros wheeleri, a deep-sea fish inhabiting the Emperor Seamount Chain caused a serious population decline. Therefore, it is urgently necessary to clarify its genetic diversity and connectivity among populations of P. wheeleri for appropriate stock management. For this, we compared 677 base pairs (bp) of mitochondrial (mt) DNA control region (CR) sequences of 80 individuals from three seamounts (the Milwaukee, Kinmei, and Koko Seamounts) in the southern part of the Emperor Seamount Chain...
January 12, 2018: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29295556/emerging-roles-of-twik-1-heterodimerization-in-the-brain
#2
REVIEW
Chang-Hoon Cho, Eun Mi Hwang, Jae-Yong Park
Two-pore domain K⁺ (K2P) channels play essential roles in regulating resting membrane potential and cellular excitability. Although TWIK-1 (TWIK-tandem of pore domains in a weak inward rectifying K⁺ channel) was the first identified member of the K2P channel family, it is only in recent years that the physiological roles of TWIK-1 have been studied in depth. A series of reports suggest that TWIK-1 may underlie diverse functions, such as intrinsic excitability of neurons, astrocytic passive conductance, and astrocytic glutamate release, as a homodimer or heterodimer with other K2P isotypes...
December 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29274133/adenosine-a1-receptor-activates-background-potassium-channels-and-modulates-information-processing-in-olfactory-bulb-mitral-cells
#3
Natalie Rotermund, Svenja Winandy, Timo Fischer, Kristina Schulz, Torsten Fregin, Nadine Breitkreutz, Melanie Buchta, Janick Bartels, Mattias Carlström, Christian Lohr, Daniela Hirnet
Neuromodulation by adenosine is of critical importance in many brain regions, but the role of adenosine in olfactory information processing has not been studied so far. We investigated the effects of adenosine on mitral cells, which are projection neurons of the olfactory bulb. Significant expression of A1 and A2A receptors was found in mitral cells, as demonstrated by in situ hybridization. Application of adenosine in acute olfactory bulb slices hyperpolarized mitral cells in wild type, but not in adenosine A1 receptor knockout mice...
December 22, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29272986/genetic-divergence-of-isolated-populations-of-the-native-micromoth-bucculatrix-mirnae-lepidoptera-bucculatricidae-in-the-arid-environments-of-northern-chile
#4
Marcelo Vargas-Ortiz, Dante Bobadilla, Wilson Huanca-Mamani, Héctor A Vargas
Analysis of maternally inherited genes is especially helpful in population studies of host-specialized insects, as female dispersal is key to find an adequate host plant to ensure larval survival. Bucculatrix mirnae (Lepidoptera: Bucculatricidae) is a little-known Neotropical micromoth native to the arid environments of northern Chile whose hypermetamorphic larvae are miners and skeletonizers on leaves of two species of Baccharis (Asteraceae) shrubs. This micromoth has been detected in three isolated locations embracing a narrow geographic range: two from the coastal valleys of the Atacama Desert near sea level and one from the western slopes of the Andes at about 3000 m elevation...
December 22, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29245529/-i-hexapleomera-urashima-i-sp-nov-crustacea-tanaidacea-a-tanaidid-epibiotic-on-loggerhead-sea-turtles-at-yakushima-island-japan
#5
Yuki Tanabe, Ryota Hayashi, Shinri Tomioka, Keiichi Kakui
We describe Hexapleomera urashima sp. nov. from the carapaces of loggerhead sea turtles (Caretta caretta) on Yakushi-ma Island, southwestern Japan, the primary nesting site for the North Pacific population of this turtle. Hexapleomera urashima closely resembles H. edgari Bamber collected from Australian loggerheads (South Pacific population), sharing a uropod with four articles and maxillipedal endites with distal spiniform setae, but differs in having the maxillipedal coxa with two simple setae, the maxillipedal endite with two tiny dorsosubdistal and two distal spiniform setae, the labial palp fused to the outer lobe of the labium, and the basal article of pleopod 3 without inner setae...
November 22, 2017: Zootaxa
https://www.readbyqxmd.com/read/29245523/a-new-species-of-i-raricirrus-i-annelida-cirratuliformia-from-deep-water-sunken-wood-off-california
#6
Wagner F Magalhães, Katrin Linse, Helena Wiklund
The genus Raricirrus is characterized by the absence of feeding palps, presence of filamentous branchiae, posterior segments shorter and wider than preceding ones, and by having diverse types of chaetae, including serrate capillaries, long natatory capillaries, falcate and finely pectinate, coarsely serrate chaetae and simple curved spines. A new species of Raricirrus is proposed based on morphological and mitochondrial DNA data. The K2P distance comparison of 16S and COI sequences from Raricirrus specimens collected from sunken wood in the deep-sea (3100 m) off Monterey, California, differed in less than 0...
November 22, 2017: Zootaxa
https://www.readbyqxmd.com/read/29245435/-i-electrogena-i-i-brulini-i-sp-nov-and-i-e-vipavensis-i-zurwerra-amp-tomka-1986-syn-nov-revealed-by-integrative-taxonomy-of-i-e-gridellii-i-grandi-1953-ephemeroptera-heptageniidae
#7
Andre Wagner, Laurent Vuataz, Michel Sartori
A new species belonging to the speciose genus Electrogena Zurwerra & Tomka, 1985 is described based on all stages from material collected in Switzerland, northern Italy and Slovenia. Electrogena brulini Wagner sp. nov. is closely related to E. gridellii (Grandi, 1953). A genetic analysis based on the mitochondrial gene CO1, including 9 specimens from 5 populations, reveals a K2P distance of 22% between both species. Our investigations demonstrate that the description of the nymph of E. gridellii sensu Belfiore (1996) refers in fact to both species...
December 5, 2017: Zootaxa
https://www.readbyqxmd.com/read/29205365/taking-intestinal-anion-secretion-to-task-a-role-for-k2p-channels-in-cyclic-amp-regulated-anion-secretion
#8
Scott M O'Grady
Intestinal anion secretion has been the focus of numerous investigations ever since the discovery of its essential role in diarrheal disease. This article is protected by copyright. All rights reserved.
December 3, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29179200/stress-kinase-regulation-of-task-1-and-task-3
#9
Susanne Rinné, Aytug K Kiper, Constanze Schmidt, Beatriz Ortiz-Bonnin, Simone Zwiener, Guiscard Seebohm, Niels Decher
BACKGROUND/AIMS: TASK channels belong to the two-pore-domain potassium (K2P) channel family. TASK-1 is discussed to contribute to chronic atrial fibrillation (AFib) and has been together with uncoupling protein 1 found as a marker protein of brown adipose tissue (BAT) fat. In addition, TASK-1 was linked in a genome-wide association study to an increased body mass index. A recent study showed that TASK-1 inhibition is causing obesity in mice by a BAT whitening and that these effects are linked to the mineralocorticoid receptor pathway, albeit the mechanism remained elusive...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29161494/species-of-sand-flies-diptera-psychodidae-collected-from-natural-reserves-in-the-pacific-and-darien-regions-of-colombia
#10
Rafael J Vivero, María Angélica Contreras, Juan D Suaza, Iván D Vélez, Charles Porter, Sandra Uribe
INTRODUCTION: The departments of Chocó and Antioquia in Colombia show climatic and vegetation conditions favoring the establishment of vector species of the genus Lutzomyia and the transmission of Leishmania spp. to human populations entering conserved forest environments. OBJECTIVE: To report the species of Phlebotomine sandflies present in three natural reserves in the Darien and Pacific regions of Colombia. MATERIALS AND METHODS: Sand flies were collected specifically in the natural reserves El Aguacate (Acandí, Chocó), Nabugá (Bahía Solano, Chocó) and Tulenapa (Carepa, Antioquia)...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29156592/activation-of-trek-1-but-not-trek-2-channel-by-mood-stabilizers
#11
Eun-Jin Kim, Dong Kun Lee, Seong-Geun Hong, Jaehee Han, Dawon Kang
Earlier studies have demonstrated that the tandem pore domain weak inward rectifying K⁺ channel (TWIK)-related K⁺ (TREK)-1 channel is inhibited by antidepressants and is associated with major depression. However, little is known about the effect of mood stabilizers that are commonly used for treatment of bipolar disorder on TREK channels, members of the two-pore domain K⁺ (K2P) channel family. This study sought to investigate the effect of mood stabilizers on TREK-1 and TREK-2 channels. HEK-293A cells were transfected with human TREK-1 or TREK-2 DNA...
November 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29150838/gi-530159-a-novel-selective-mechano-sensitive-k2p-channel-opener-reduces-rat-dorsal-root-ganglion-drg-neuron-excitability
#12
Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Katrina Yoger, Emma L Veale, Anna Wilbrey, Kiyoyuki Omoto, Lishuang Cao, Alex Gutteridge, Neil A Castle, Edward B Stevens, Alistair Mathie
BACKGROUND AND PURPOSE: TREK two pore domain potassium channels play a critical role in regulating the excitability of somatosensory nociceptive neurons and are important mediators of pain perception. An understanding of the roles of TREK channels in pain perception and, indeed, in other pathophysiological conditions, has been severely hampered by the lack of potent and/or selective activators and inhibitors. In this study we describe a new, selective opener of TREK channels, GI-530159 (4,4'-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline)...
November 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29143340/k2p-task-2-and-kcnq1-kcne3-k-channels-are-major-players-contributing-to-intestinal-anion-and-fluid-secretion
#13
Francisca Julio-Kalajzić, Sandra Villanueva, Johanna Burgos, Margarita Ojeda, L Pablo Cid, Thomas J Jentsch, Francisco V Sepúlveda
Anion and fluid secretion across the intestinal epithelium, a process altered in cystic fibrosis and secretory diarrhoea, is mediated by cAMP-activated CFTR Cl- channels and requires the simultaneous activity of basolateral K+ channels to maintain cellular ionic homeostasis and membrane potential. This function is fulfilled by the cAMP-activated K+ channel formed by the association of pore-forming KCNQ1 with its obligatory KCNE3 β-subunit. Studies using mice show sizable cAMP-activated intestinal anion secretion in the absence of either KCNQ1 or KCNE3 suggesting that an alternative K+ conductance must compensate for the loss of KCNQ1/KCNE3 activity...
November 16, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29071864/-identification-of-ranae-oviductus-original-animal-based-on-coi-sequences
#14
Meng-Hu Wang, Ting-Guo Kang, Liang Xu, Yan-Yun Yang, Zhen-Jiao Cai
Ranae Oviductus has a high economic and social value, but its adulterants are more numerous, which causes a great confusion to the market. Using DNA bar code technology based on COI sequence for PCR amplification and sequencing of the identified Rana dybowskii, R. chensinensis, R. huanrensis and R. amurensiss, the COI gene database of four species of Rana was established, and comparing the measured sequence with the sequence of GenBank, four kinds of Rana were identified. The MEGA (molecular evolutionary genetics analysis) 7 ...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29058189/studying-mechanosensitivity-of-two-pore-domain-k-channels-in-cellular-and-reconstituted-proteoliposome-membranes
#15
Josefina Del Mármol, Robert A Rietmeijer, Stephen G Brohawn
Mechanical force sensation is fundamental to a wide breadth of biology from the classic senses of touch, pain, hearing, and balance to less conspicuous sensations of proprioception, blood pressure, and osmolarity and basic aspects of cell growth, differentiation, and development. These diverse and essential systems use force-gated (or mechanosensitive) ion channels that convert mechanical stimuli into cellular electrical signals. TRAAK, TREK1, and TREK2 are K(+)-selective ion channels of the two-pore domain K(+) (K2P) family that are mechanosensitive: they are gated open by increasing membrane tension...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29016681/heterodimerization-of-two-pore-domain-k-channel-task1-and-talk2-in-living-heterologous-expression-systems
#16
Yoshiaki Suzuki, Kanako Tsutsumi, Tatsuya Miyamoto, Hisao Yamamura, Yuji Imaizumi
Two-pore-domain K+ (K2P) channels sense a wide variety of stimuli such as mechanical stress, inhalational anesthetics, and changes in extracellular pH or temperature. The K2P channel activity forms a background K+ current and, thereby, contributes to resting membrane potentials. Six subfamilies including fifteen subtypes of K2P channels have been identified. Each K2P channel molecule with two pores consists of a homodimer of each subtype. In addition, a few heterodimers mainly within the same subfamilies have been found recently...
2017: PloS One
https://www.readbyqxmd.com/read/28984357/endocytosis-another-pathway-in-receptor-gq-task-signalling
#17
Donghee Kim
No abstract text is available yet for this article.
November 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28937755/stability-and-superconductivity-of-k-p-compounds-under-pressure
#18
Yunxian Liu, Chao Wang, Xiangmu Kong, Defang Duan
We explore the phase diagram, structures, electron properties, and potential superconductivity of the K-P system at pressures of up to 200 GPa through unbiased structure searching techniques and first-principles calculations. Five stable chemical stoichiometries (K4P, K3P, K2P, KP, and KP2) have been theoretically predicted. In particular, P2 units or P-chains are uncovered in K2P, KP, and KP2 compounds with the existence of covalent bonds by analyzing the electron localization functions. And the Bader analysis demonstrates that charges transfer from K atoms to P atoms...
September 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28937579/pyrethroids-inhibit-k2p-channels-and-activate-sensory-neurons-basis-of-insecticide-induced-paraesthesias
#19
Aida Castellanos, Alba Andres, Laura Bernal, Gerard Callejo, Nuria Comes, Arcadi Gual, Jonathan P Giblin, Carolina Roza, Xavier Gasull
Pyrethroid insecticides are widely used for pest control in agriculture or in human public health commonly as a topical treatment for scabies and head lice. Exposure to pyrethroids such as permethrin or tetramethrin (TM) causes sensory alterations such as transient pain, burning, stinging sensations, and paraesthesias. Despite the well-known effects of pyrethroids on sodium channels, actions on other channels that control sensory neuron excitability are less studied. Given the role of 2-pore domain potassium (K2P) channels in modulating sensory neuron excitability and firing, both in physiological and pathological conditions, we examined the effect of pyrethroids on K2P channels mainly expressed in sensory neurons...
September 25, 2017: Pain
https://www.readbyqxmd.com/read/28933086/-identification-of-dryopteridis-crassirhizomatis-rhizoma-based-on-psba-trnh-barcode
#20
Zhen-Jiao Cai, Ya-Nan Wu, Liang Xu, Rong Zhao, Bing Wang, Ting-Guo Kang
To identify origin of the medicinal materials Dryopteridis Crassirhizomatis Rhizoma by using the psbA-trnH sequence, the polymerase chain reaction (PCR) amplification and product sequencing of the experimental samples were performed. In order to expand the scope of the study, the psbA-trnH sequences of 8 genera and 3 species were downloaded from GenBank for analysis. DNAMAN 8.0 software was used to show splicing and comparison results of the peak diagrams with analysis of them, and MEGA 6.0 software was to calculate K2P genetic distances and establish clustering tree adjacent genus...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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