Amy E Sutherland, Tegan A White, Charmaine R Rock, Beth R Piscopo, Ingrid Dudink, Ishmael M Inocencio, Zahrah Azman, Yen Pham, Ilias Nitsos, Atul Malhotra, Tamara Yawno, Graeme R Polglase, Graham Jenkin, Emily J Camm, Beth J Allison, Suzanne L Miller
INTRODUCTION: Fetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development in utero and postnatal wellbeing. There are no antenatal treatments to improve growth or organ development in FGR, and animal models are essential to mimic the physiological adaptations in FGR and to assess potential interventions. This study aimed to identify the temporal nature of reduced developmental trajectory in fetuses with FGR, and to examine the effects of common factors that may mediate differential growth such as glucocorticoid treatment...
2024: Frontiers in Endocrinology