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https://www.readbyqxmd.com/read/28635672/towards-the-internet-of-smart-trains-a-review-on-industrial-iot-connected-railways
#1
Paula Fraga-Lamas, Tiago M Fernández-Caramés, Luis Castedo
Nowadays, the railway industry is in a position where it is able to exploit the opportunities created by the IIoT (Industrial Internet of Things) and enabling communication technologies under the paradigm of Internet of Trains. This review details the evolution of communication technologies since the deployment of GSM-R, describing the main alternatives and how railway requirements, specifications and recommendations have evolved over time. The advantages of the latest generation of broadband communication systems (e...
June 21, 2017: Sensors
https://www.readbyqxmd.com/read/28635376/advances-in-understanding-the-role-of-disease-associated-proteins-in-spinal-muscular-atrophy
#2
Seyyedmohsen Hosseinibarkooie, Svenja Schneider, Brunhilde Wirth
Spinal muscular atrophy (SMA) is a neurodegenerative disorder characterized by alpha motor neuron loss in the spinal cord due to reduced survival of motor neuron (SMN) protein level. While the genetic basis of SMA is well described, the specific molecular pathway underlying SMA is still not fully understood. Areas covered: This review discusses the recent advancements in understanding the molecular pathways in SMA using different omics approaches and genetic modifiers identified in both vertebrate and invertebrate systems...
June 21, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28630150/cryo-electron-tomography-an-ideal-method-to-study-membrane-associated-proteins
#3
REVIEW
Michelle A Dunstone, Alex de Marco
Cryo-electron tomography (cryo-ET) is a three-dimensional imaging technique that makes it possible to analyse the structure of complex and dynamic biological assemblies in their native conditions. The latest technological and image processing developments demonstrate that it is possible to obtain structural information at nanometre resolution. The sample preparation required for the cryo-ET technique does not require the isolation of a protein and other macromolecular complexes from its native environment. Therefore, cryo-ET is emerging as an important tool to study the structure of membrane-associated proteins including pores...
August 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28627120/new-insights-into-human-primordial-germ-cells-and-early-embryonic-development-from-single-cell-analysis
#4
REVIEW
Jörg Otte, Wasco Wruck, James Adjaye
Human preimplantation developmental studies are difficult to accomplish due to associated ethical and moral issues. Preimplantation cells are rare and exist only in transient cell states. From a single cell, it is very challenging to analyse the origination of the heterogeneity and complexity inherent to the human body. However, recent advances in single-cell technology and data analysis have provided new insights into the process of early human development and germ cell specification. In this Review, we examine the latest single-cell datasets of human preimplantation embryos and germ cell development, compare them to bulk cell analyses, and interpret their biological implications...
June 18, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28626080/cyp2c44-mediated-decrease-of-15-hete-exacerbates-pulmonary-hypertension
#5
Gábor Á Fülöp, Andriy Yabluchanskiy
Pulmonary hypertension (PH) is a progressive disease characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance. According to latest estimations, a PH incidence accounts for 1% of total global population (up to 5 million people) and the median survival rate for patients diagnosed with PH is predicted at 2.8 years. Emerging evidence suggests an important role for cytochrome P450 in the development and progression of PH, as a newer member of cytochrome family Cyp2c44 has been recently implicated in mediating hypoxia-induced pulmonary artery remodeling...
June 16, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28620966/the-embodied-nurse-interdisciplinary-knowledge-exchange-between-compassionate-nursing-and-recent-developments-in-embodied-leadership-studies
#6
Kushwanth Koya, Jane Anderson, Petia Sice
AIM: To report a potential knowledge exchange between nursing studies and the results obtained from a study conducted into the attributes of embodied leadership. BACKGROUND: Leadership theories have been applied to evaluate, improve and train nursing practitioners in several previous studies. However, leadership research has entered a new phase where the focus is to produce sustainable leaders through authenticity and compassion, the same two characteristics identified as being of most success in emergent nursing practice...
June 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28618904/antiplatelet-and-antithrombotic-treatment-for-secondary-prevention-in-ischaemic-heart-disease
#7
Maddalena Lettino, Sergio Leonardi, Elia De Maria, Sigrun Halvorsen
Platelets play a key role in the pathogenesis of acute coronary syndromes and this is why antiplatelet drugs are essential, both in the acute phase and in the long-term follow-up in preventing recurrent myocardial infarction, stroke and cardiovascular death. Aspirin is the most used agent and still remains the first choice drug for lifelong administration in secondary prevention after myocardial infarction. Dual antiplatelet therapy, targeting more than one pathway of platelet activation, has significantly improved the outcome of patients with acute coronary syndromes despite an increased risk of bleeding complications...
June 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28618036/ultra-low-radiation-dose-during-electrophysiology-procedures-using-optimised-new-generation-fluoroscopy-technology
#8
James Crowhurst, Haris Haqqani, Daniel Wright, Daniel Wright, Mark Whitby, Adam Lee, John Betts, Russell Denman
BACKGROUND: Electrophysiology procedures require fluoroscopic guidance, with the associated potentially adverse effects of ionising radiation. Newer fluoroscopy systems have more features that enable dose-reduction strategies. This study aimed to investigate any reduction in radiation dose between an older fluoroscopy system (Philips Integris H5000) and one of the latest systems (Siemens Artis Q), optimised with dose-reduction strategies. METHODS: Radiation dose measures were collected over a two year period in a single electrophysiology laboratory...
June 15, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28618012/metabolomic-signature-of-brain-cancer
#9
Renu Pandey, Laura Caflisch, Alessia Lodi, Andrew J Brenner, Stefano Tiziani
Despite advances in surgery and adjuvant therapy, brain tumours represent one of the leading causes of cancer-related mortality and morbidity in both adults and children. Gliomas constitute about 60% of all cerebral tumours, showing varying degrees of malignancy. They are difficult to treat due to dismal prognosis and limited therapeutics. Metabolomics is the untargeted and targeted analyses of endogenous and exogenous small molecules, which characterizes the phenotype of an individual. This emerging "omics" science provides functional readouts of cellular activity that contribute greatly to the understanding of cancer biology including brain tumour biology...
June 15, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28617364/-a-current-view-on-the-mri-diagnosis-of-multiple-sclerosis-an-update-of-2016-revised-mri-criteria
#10
V V Bryukhov, I A Krotenkova, S N Morozova, M V Krotenkova
Magnetic resonance imaging (MRI) is the primary method for confirming the clinical diagnosis of multiple sclerosis (MS). The article presents the current data on using MRI of the brain and spinal cord for diagnosis in suspected MS. Special attention is paid to the MRI criteria of McDonald and MAGNIMS for relapsing-remitting MS (RRMS) and primary-progressive MS (PPMS) in the latest revisions of 2010 and 2016. The information provided can help radiologists and neurologists to optimize the use of MRI in clinical practice for diagnosis of MS...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28616955/niacin-for-primary-and-secondary-prevention-of-cardiovascular-events
#11
REVIEW
Stefan Schandelmaier, Matthias Briel, Ramon Saccilotto, Kelechi K Olu, Armon Arpagaus, Lars G Hemkens, Alain J Nordmann
BACKGROUND: Nicotinic acid (niacin) is known to decrease LDL-cholesterol, and triglycerides, and increase HDL-cholesterol levels. The evidence of benefits with niacin monotherapy or add-on to statin-based therapy is controversial. OBJECTIVES: To assess the effectiveness of niacin therapy versus placebo, administered as monotherapy or add-on to statin-based therapy in people with or at risk of cardiovascular disease (CVD) in terms of mortality, CVD events, and side effects...
June 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28612339/osteocyte-mechanobiology
#12
REVIEW
Yuhei Uda, Ehab Azab, Ningyuan Sun, Chao Shi, Paola Divieti Pajevic
PURPOSE OF REVIEW: Over the past decades, osteocytes have emerged as mechano-sensors of bone and master regulators of bone homeostasis. This article summarizes latest research and progress made in understanding osteocyte mechanobiology and critically reviews tools currently available to study these cells. RECENT FINDINGS: Whereas increased mechanical forces promote bone formation, decrease loading is always associated with bone loss and skeletal fragility. Recent studies identified cilia, integrins, calcium channels, and G-protein coupled receptors as important sensors of mechanical forces and Ca(2+) and cAMP signaling as key effectors...
June 13, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28607580/neoadjuvant-chemotherapy-in-soft-tissue-sarcomas-latest-evidence-and-clinical-implications
#13
REVIEW
Sandro Pasquali, Alessandro Gronchi
Soft tissue sarcomas are a rare and multifaceted group of solid tumours. Neoadjuvant chemotherapy is increasingly used to limit loss of function after wide surgical excision with the ultimate aim of improving patient survival. Recently, advances in the identification of effective treatment strategies and improvements in patient risk stratification have been reached. A randomized trial demonstrated that neoadjuvant epirubicin and ifosfamide improves survival of patients affected by five high-risk soft tissue sarcoma histologies of trunk and extremities, including undifferentiated pleomorphic sarcoma, myxoid liposarcoma, synovial sarcoma, malignant peripheral nerve sheath tumours, and leiomyosarcoma...
June 2017: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/28603661/a-high-strength-absorbable-antibacterial-knotless-tissue-control-device-for-fascial-closure
#14
REVIEW
Jesse G Nawrocki, Heather Nonnenmann, Mark Mooney, Nadia Sutton, Niels-Derrek Schmitz
PURPOSE OF REVIEW: This review provides an overview of the STRATAFIX™ SYMMETRIC PDS™ Plus Knotless Tissue Control Device design and performance characteristics and highlights the device's relevance for use in gynecological procedures. Various device testing was conducted on tensile strength, fixation tab mass comparison to conventional suture knot tower, initiation stitch strength, and wound holding strength to highlight the STRATAFIX™ SYMMETRIC PDS™ Plus Device's key product attributes that may benefit general and minimally invasive gynecological procedures...
2017: Current Obstetrics and Gynecology Reports
https://www.readbyqxmd.com/read/28601174/thoracic-neoplasms-in-children-contemporary-perspectives-and-imaging-assessment
#15
REVIEW
Matthew A Zapala, Victor M Ho-Fung, Edward Y Lee
This article focuses on commonly encountered primary lung, airway, mediastinal, and chest wall neoplasms that occur in the pediatric population. Although primary pediatric thoracic neoplasms are rare, imaging is critical in their diagnostic work-up. An overview of the latest imaging techniques specific to evaluate these pediatric thoracic neoplasms is presented across the spectrum of modalities from radiography to PET/MR imaging. In addition, the characteristic imaging appearances of these pediatric primary thoracic neoplasms are discussed with an emphasis on what the radiologist needs to know in routine clinical practice...
July 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28599081/mechanisms-of-exercise-induced-bronchoconstriction-in-athletes-current-perspectives-and-future-challenges
#16
REVIEW
Mariana Couto, Marcin Kurowski, André Moreira, Dominique M A Bullens, Kai-Håkon Carlsen, Luís Delgado, Marek L Kowalski, Sven F Seys
The evidence of exercise-induced bronchoconstriction (EIB) without asthma (EIBwA ) occurring in athletes led to speculate about different endotypes inducing respiratory symptoms within athletes. Classical postulated mechanisms for bronchial obstruction in this population include the osmotic and the thermal hypotheses. More recently, the presence of epithelial injury and inflammation in the airways of athletes was demonstrated. In addition, neuronal activation has been suggested as a potential modulator of bronchoconstriction...
June 9, 2017: Allergy
https://www.readbyqxmd.com/read/28594133/diagnostic-value-of-stmn1-lmo2-hgal-aid-expression-and-1p36-chromosomal-abnormalities-in-primary-cutaneous-b-cell-lymphomas
#17
Evelyne Verdanet, Olivier Dereure, Céline René, Ariane Tempier, Assia Benammar-Hafidi, Mathieu Gallo, Eric Frouin, Luc Durand, Isabelle Gazagne, Valérie Costes-Martineau, Valère Cacheux, Vanessa Szablewski
INTRODUCTION: distinction between primary cutaneous follicular lymphoma (PCFL) and primary cutaneous marginal zone lymphoma (PCMZL) is challenging as clear-cut immunophenotypic and cytogenetic criteria to segregate both entities are lacking. MATERIALS AND METHODS: to better characterize PCFL and PCMZL and to define criteria helpful for the differential diagnosis, we compared expression of immunohistochemical markers (LMO2, HGAL, STMN1, AID, MNDA) and the presence of cytogenetic abnormalities previously described in nodal follicular lymphoma (BCL2 and BCL6 breaks, 1p36 chromosomal region deletion (del 1p36)) in a series of 48 cutaneous follicular and marginal zone lymphomas (CFL and CMZL)...
June 8, 2017: Histopathology
https://www.readbyqxmd.com/read/28593359/guided-growth-for-valgus-deformity-correction-of-knees-in-a-girl-with-osteopetrosis-a-case-report
#18
Dmitry Popkov
Autosomal dominant osteopetrosis (Albers-Schönberg disease) classically displays the radiographic signs of osteosclerosis. The main ADO complications involve the skeleton: low-impact bone fractures, scoliosis and hip osteoarthritis. Management of osteopetrosis-related orthopedic problems is a surgical challenge due to increased bone density. The healing process is very slow in these patients because of bone remodeling defects related to osteoblast function failure. In case of bone deformities, a realignment method should be appropriated to osteopetrosis conditions...
June 7, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28586525/novel-therapeutic-clues-in-thyroid-carcinomas-the-role-of-targeting-cancer-stem-cells
#19
REVIEW
Alessandro Antonelli, Concettina La Motta
Thyroid carcinomas (TCs), the most common endocrine tumors, represent the eighth most common cancer diagnosed worldwide in both women and men. To treat these malignancies, several drugs are now available and a number of novel ones have been enrolling in clinical trials, addressing both oncogenic pathways in cancer cells and angiogenic pathways in tumor endothelial cells. However, their use is not devoid of serious toxicities and their efficacy is limited, being dependent on carcinoma typology and the occurrence of acquired resistance...
June 6, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28585923/dats-the-data-tag-suite-to-enable-discoverability-of-datasets
#20
Susanna-Assunta Sansone, Alejandra Gonzalez-Beltran, Philippe Rocca-Serra, George Alter, Jeffrey S Grethe, Hua Xu, Ian M Fore, Jared Lyle, Anupama E Gururaj, Xiaoling Chen, Hyeon-Eui Kim, Nansu Zong, Yueling Li, Ruiling Liu, I Burak Ozyurt, Lucila Ohno-Machado
Today's science increasingly requires effective ways to find and access existing datasets that are distributed across a range of repositories. For researchers in the life sciences, discoverability of datasets may soon become as essential as identifying the latest publications via PubMed. Through an international collaborative effort funded by the National Institutes of Health (NIH)'s Big Data to Knowledge (BD2K) initiative, we have designed and implemented the DAta Tag Suite (DATS) model to support the DataMed data discovery index...
June 6, 2017: Scientific Data
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