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https://www.readbyqxmd.com/read/29684939/loose-lipped-mobile-device-intelligent-personal-assistants-a-discussion-of-information-gleaned-from-siri-on-locked-ios-devices
#1
Graeme Horsman
The forensic analysis of mobile handsets is becoming a more prominent factor in many criminal investigations. Despite such devices frequently storing relevant evidential content to support an investigation, accessing this information is becoming an increasingly difficult task due to enhanced effective security features. Where access to a device's resident data is not possible via traditional mobile forensic methods, in some cases it may still be possible to extract user information via queries made to an installed intelligent personal assistant...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29683095/azilsartan-and-chlorthalidone-new-powerful-fixed-dose-antihypertensive-combination
#2
Vasiliki Katsi, Eleni Athanasiadi, Costas Tsioufis, Dimitris Tousoulis
Arterial hypertension is a disease that still affects a major part of the population worldwide, and leads to fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. From the CDC statistical analysis, as regarding to United States, 1 of every 3 adults has high blood pressure, and οnly about half (54%) of them have it under control. Furthermore, all that leads to a nation cost about $46 billion each year. Efforts to find new ways to regulate arterial hypertension are therefore imperative...
April 20, 2018: Current Hypertension Reviews
https://www.readbyqxmd.com/read/29675958/detection-of-allergenic-additives-in-processed-meat-products
#3
REVIEW
Anita Spychaj, Edward Pospiech, Ewa Iwańska, Magdalena Montowska
At present, allergic response to food components is an increasing problem all over the world. Therefore it is important to protect people vulnerable to food allergens against accidental and unintended consumption of products containing allergic ingredients. The meat industry commonly uses various allergic additives in production of processed products, i.e. legumes (soy, peas, beans), milk and egg preparations, cereals containing gluten (wheat, rye, barley and oats), and spices (celery and mustard). These meat additives have specific technological properties which help to create a texture, flavour profile or affect the nutritional value, although some of them, such as soy, mustard, milk and egg white proteins can cause severe allergic reactions...
April 19, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29673987/recovery-of-biotechnological-products-using-aqueous-two-phase-systems
#4
REVIEW
Win Nee Phong, Pau Loke Show, Yin Hui Chow, Tau Chuan Ling
Aqueous two-phase system (ATPS) has been suggested as a promising separation tool in the biotechnological industry. This liquid-liquid extraction technique represents an interesting advance in downstream processing due to several advantages such as simplicity, rapid separation, efficiency, economy, flexibility and biocompatibility. Up to date, a range of biotechnological products have been successfully recovered from different sources with high yield using ATPS-based strategy. In view of the important potential contribution of the ATPS in downstream processing, this review article aims to provide latest information about the application of ATPS in the recovery of various biotechnological products in the past 7 years (2010-2017)...
April 16, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29673082/a-minion-based-pipeline-for-fast-and-cost-effective-dna-barcoding
#5
Amrita Srivathsan, Bilgenur Baloğlu, Wendy Wang, Wei Xin Tan, Denis Bertrand, Amanda Hui Qi Ng, Esther Jia Hui Boey, Jayce Jia Yu Koh, Niranjan Nagarajan, Rudolf Meier
DNA barcodes are useful for species discovery and species identification, but obtaining barcodes currently requires a well-equipped molecular laboratory, is time-consuming, and/or expensive. We here address these issues by developing a barcoding pipeline for Oxford Nanopore MinION™ and demonstrate that one flowcell can generate barcodes for ~500 specimens despite the high base-call error rates of MinION™ reads. The pipeline overcomes these errors by first summarizing all reads for the same tagged amplicon as a consensus barcode...
April 19, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29672174/th9-cells-probable-players-in-ulcerative-colitis-pathogenesis
#6
Mojtaba Shohan, Shokrollah Elahi, Hedayatollah Shirzad, Mahmoud Rafieian-Kopaei, Nader Bagheri, Emad Soltani
T lymphocytes represent an important part of adaptive immune system undertaking different functions to regulate immune responses. CD4+ T cells are the most important activator cells in inflammatory conditions. Depending on the type of induced cells and inflamed sites, expression and activity of different subtypes of helper T cells are changed. Recent studies have confirmed the existence of a new subset of helper T lymphocytes called Th9. Naive T cells can differentiate into Th9 subtypes if they are exposed simultaneously by interleukin (IL) 4 and transforming growth factor β and also secondary activation of a complicated network of transcription factors such as interferon regulatory factor 4 (IRF4) and Smads which are essential for adequate induction of this phenotype...
April 19, 2018: International Reviews of Immunology
https://www.readbyqxmd.com/read/29671367/3d-bio-printing-technology-for-body-tissues-and-organs-regeneration
#7
Esmaeil Biazar, Masoumeh Najafi S, Saeed Heidari K, Meysam Yazdankhah, Ataollah Rafiei, Dariush Biazar
In the last decade, the use of new technologies in the reconstruction of body tissues has greatly developed. Utilising stem cell technology, nanotechnology and scaffolding design has created new opportunities in tissue regeneration. The use of accurate engineering design in the creation of scaffolds, including 3D printers, has been widely considered. Three-dimensional printers, especially high precision bio-printers, have opened up a new way in the design of 3D tissue engineering scaffolds. In this article, a review of the latest applications of this technology in this promising area has been addressed...
April 19, 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29668975/the-great-debate-series-surgical-treatment-of-aortic-valve-abnormalities-in-children
#8
Yves d'Udekem, James S Tweddell, Tom R Karl
This article is the latest in an EJCTS series entitled 'The Great Debates'. We have chosen the topic of aortic valve (AoV) surgery in children, with a focus on infants and neonates. The topic was selected due to the significant challenges that AoV problems in the young may present to the surgical team. There are many areas of active controversy, despite the vast accumulated world experience. We have tried to incorporate many of these issues in the questions posed, not claiming to be all-inclusive. The individuals invited to this debate are experts in paediatric valve surgery, with broad and successful clinical experiences on multiple continents...
May 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29662760/macrophages-and-bone-inflammation
#9
REVIEW
Qiaoli Gu, Huilin Yang, Qin Shi
Bone metabolism is tightly regulated by the immune system. Accelerated bone destruction is observed in many bone diseases, such as rheumatoid arthritis, fracture, and particle-induced osteolysis. These pathological conditions are associated with inflammatory responses, suggesting the contribution of inflammation to bone destruction. Macrophages are heterogeneous immune cells and are polarized into the proinflammatory M1 and antiinflammatory M2 phenotypes in different microenvironments. The cytokines produced by macrophages depend on the macrophage activation and polarization...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661663/right-on-target
#10
Omer M Farhan-Alanie, David F Howie, Jonathan O'Reilly, Jacqui MacNair
Targets have become an integral part of health care, whether we agree with them or not. Many accept the progress made with the use of targets, but our duty as health professionals is to ensure that their use and interpretation is undertaken with the same care and understanding of their limitations that we apply to our clinical practice, and that they are not mis-interpreted or used to justify the latest political idioms. Currently the healthcare profession is failing to understand the consequences of setting targets, or the wider implications of hitting them...
April 13, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29659071/traditional-and-new-media-s-influence-on-suicidal-behavior-and-contagion
#11
Patricia Ortiz, Eindra Khin Khin
The role of nonfictional and fictional media in suicide contagion has been well established, ostensibly beginning with the publication of Goethe's The Sorrows of Young Werther in 1774. In recent decades, the emergence of several new forms of media (e.g. websites, social media, blogs, smartphone applications) has revolutionized the communication and social interaction paradigms. This article reviews "the Werther effect" (or suicide contagion related to media), special populations who are more influential or susceptible, current media reporting guidelines and their effectiveness, and the latest research on new media and its effect on suicide and suicide contagion...
March 2018: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/29658441/efficacy-of-transcranial-direct-current-stimulation-combined-with-cognitive-training-in-the-treatment-of-apathy-in-patients-with-alzheimer-s-disease-study-protocol-for-a-randomized-trial
#12
Jean-Paul Nguyen, Claire Boutoleau-Bretonniere, Jean-Pascal Lefaucheur, Alcira Suarez, Helene Gaillard, Guillaume Chapelet, Sebastien Abad, Aurelien Van Langhenhove, Julian Nizard, Laure de Decker
BACKGROUND: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Isolated cognitive training also appears to have no effect on apathy. We propose to test the efficacy of a new procedure for the treatment of apathy in AD patients consisting of a combination of tDCS and cognitive training, based on the latest guidelines for the design of therapeutic trials in this field...
April 16, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29645344/functional-and-oncologic-outcomes-of-open-laparoscopic-and-robotic-partial-nephrectomy-a-multicenter-comparative-matched-pair-analyses-with-a-median-5-years-follow-up
#13
Ki Don Chang, Ali Abdel Raheem, Kwang Hyun Kim, Cheol Kyu Oh, Sung Yul Park, Young Sik Kim, Won Sik Ham, Woong Kyu Han, Young Deuk Choi, Byung Ha Chung, Koon Ho Rha
PURPOSE: Data regarding the long-term oncologic and functional outcomes of robotic-assisted, laparoscopic, and open partial nephrectomy (RPN, LPN and OPN) is lacking. Our aim was to compare outcomes among RPN, LPN and OPN with a 5-year median follow-up. PATIENTS AND METHODS: We retrospectively analyzed 1308 patients who underwent PN (RPN, n=380; LPN, n=206; OPN, n=722) between 2006 and 2012 at four academic centers. We performed 1:1:1 propensity score matching adjustment based on confounding variables among groups and 366 patients (122 in each group) were included in the final analysis...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29644331/from-isolation-of-human-ovarian-follicles-to-the-artificial-ovary-tips-and-tricks
#14
Maria C Chiti, Jacques Donnez, Christiani Andrade Amorim, Marie-Madeleine Dolmans
Cryopreservation and transplantation of ovarian tissue has proved to restore both endocrine and reproductive functions in cancer patients. However women with a high risk of ovarian involvement cannot undergo ovarian tissue transplantation due to possible recurrence of the disease. Therefore, different teams worldwide are now working on the development of experimental strategies, like the transplantable artificial ovary (TAO), with the noble goal to offer to these patients hope for future conception. This article discusses some essential points for the creation of a TAO and reviews the latest progress made...
April 11, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29642749/chronic-migraine-a-process-of-dysmodulation-and-sensitization
#15
Min Su, Shengyuan Yu
Chronic migraine is a common chronic daily headache featured by frequent headache attacks with at least 15 headache days per month, which brings great disease burden to both the sufferers and the society. Transformed from episodic migraine, the pathophysiology of chronic migraine is not fully understood, even though several risk factors have been associated with migraine progression. Recent studies have identified both structural and functional alterations in some brain regions of chronic migraine patients indicating that maladaptation of the top-down pain modulation and subsequent sensitization of trigeminal system may be important in the pathogenesis of chronic migraine...
January 2018: Molecular Pain
https://www.readbyqxmd.com/read/29629341/role-of-curcumin-in-disease-prevention-and-treatment
#16
REVIEW
Arshad Husain Rahmani, Mohammed A Alsahli, Salah M Aly, Masood A Khan, Yousef H Aldebasi
Treatment based on traditional medicine is very popular in developing world due to inexpensive properties. Nowadays, several types of preparations based on medicinal plants at different dose have been extensively recognized in the diseases prevention and treatment. In this vista, latest findings support the effect of Curcuma longa and its chief constituents curcumin in a broad range of diseases cure via modulation of physiological and biochemical process. In addition, various studies based on animal mode and clinical trials showed that curcumin does not cause any adverse complications on liver and kidney function and it is safe at high dose...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29629317/surgical-management-of-neuroendocrine-tumor-associated-liver-metastases-a-review
#17
REVIEW
Miu Yee Chan, Ka Wing Ma, Albert Chan
Liver metastasis is common among patients who suffer from neuroendocrine tumors (NETs). Radical surgery is the standard treatment whenever possible but there is still controversies concerning the treatment strategies such as resection of the primary, role of debulking surgery, liver transplantation (LT) and neoadjuvant or adjuvant therapies. This article aims to review the current evidence available, together with some latest updates, focusing on the surgical management.
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29628514/state-of-the-antiretroviral-therapy-in-human-immunodeficiency-virus-drug-resistance-surveillance-and-regional-gaps
#18
Charles A Boucher, Marina R Bobkova, Chien-Ching Hung, Rolf Kaiser, Anne-Geneviève Marcelin, Adrian Streinu-Cercel, Jean van Wyk, Pat Dorr, Anne-Mieke Vandamme
This article is the second of a two-part review aiming to identify gaps in the knowledge and management of human immunodeficiency virus type 1 drug resistance (HIVDR) from global and regional perspectives. Here, we examine the policy and programmatic gaps in HIVDR surveillance, the affected populations and settings, and implications for clinical practice. The expert authorship of this review convened to identify gaps in HIVDR surveillance, with a particular focus on specific regional variations within and between Europe and Asia, to highlight directions for research and implementation...
January 2018: AIDS Reviews
https://www.readbyqxmd.com/read/29624726/-differential-mortality-and-the-excess-rates-of-hip-fracture-associated-with-type-2-diabetes-accounting-for-competing-risks-in-fracture-prediction-matters
#19
C Tebé, D Martinez-Laguna, V Moreno, C Cooper, A Diez-Perez, G S Collins, D Prieto-Alhambra
Type 2 diabetes (T2DM) is associated with a reduced life expectancy. Latest published evidence suggests an increased risk of fractures among T2DM patients. We conducted a population-based cohort study to determine the impact of mortality as a competing risk in the study of the association between T2DM and hip fracture rates. Participants were all diagnosed T2DM patients registered in the SIDIAP database aged 65 years and older; up to two non-T2DM were matched by age, sex, and primary care facility. We used Cox regression models to estimate cause-specific Hazard Ratio (HR) of death or hip fracture according to T2DM status...
April 6, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29623532/genome-editing-in-induced-pluripotent-stem-cells-using-crispr-cas9
#20
REVIEW
Ronen Ben Jehuda, Yuval Shemer, Ofer Binah
The development of the reprogramming technology led to generation of induced Pluripotent Stem Cells (iPSC) from a variety of somatic cells. Ever since, fast growing knowledge of different efficient protocols enabled the differentiation of these iPSCs into different cells types utilized for disease modeling. Indeed, iPSC-derived cells have been increasingly used for investigating molecular and cellular pathophysiological mechanisms underlying inherited diseases. However, a major barrier in the field of iPSC-based disease modeling relies on discriminating between the effects of the causative mutation and the genetic background of these cells...
April 6, 2018: Stem Cell Reviews
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