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Marit C I Lier, Romana F Malik, Johannes C F Ket, Cornelis B Lambalk, Ivo A Brosens, Velja Mijatovic
Spontaneous Hemoperitoneum in Pregnancy (SHiP), an unprovoked (nontraumatic) intraperitoneal bleeding in pregnancy (up to 42days postpartum), is associated with serious adverse pregnancy outcomes. To evaluate the clinical consequences of SHiP and its association with endometriosis, a systematic review was conducted according to the PRISMA guidelines. PubMed, and Thomson Reuters/Web of Science were searched for articles published since the latest review (August 2008) until September 2016. After assessment for eligibility, forty-four articles were included in this systematic review, describing 59 cases of SHiP...
October 12, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Lin Li, Ming-Su Liu, Guang-Qin Li, Yang Zheng, Tong-Li Guo, Xin Kang, Mao-Ting Yuan
OBJECTIVE: To provide a comprehensive and latest overview of susceptibility-weighted imaging (SWI) in the application of thrombolysis in acute ischemic stroke, and to update the decision-making effect and clinical value of SWI on identifying stroke patients suitable for thrombolytic therapy and possible benefits and risks followed. DATA SOURCES: Literatures referred to this review were collected from PubMed, Medline, and EMBASE published till May 2017, using the search terms including susceptibility-weighted imaging, gradient-echo, T2*, thrombolysis, recombinant tissue plasminogen activator (rt-PA), thrombolytic therapy, and stroke...
October 20, 2017: Chinese Medical Journal
Roberta Ara, Donna Rowen, Clara Mukuria
Mapping functions are estimated using regression analyses and are frequently used to predict health state utility values (HSUVs) in decision analytic models. Mapping functions are used when evidence on the required preference-based measure (PBM) is not available, or where modelled values are required for a decision analytic model, for example to control for important sociodemographic variables (such as age or gender). This article provides an overview of the latest recommendations including pre-mapping considerations, the mapping process including data requirements for undertaking the estimation of mapping functions, regression models for estimating mapping functions, assessing performance and reporting standards for mapping studies...
October 19, 2017: PharmacoEconomics
Karen McLean, Geeta Mehta
OBJECTIVE: The aim of this study was to review the latest research advances on the topics of the ovarian cancer tumor microenvironment and models of ovarian cancer. METHODS: In September 2016, a symposium of the leaders in the field of ovarian cancer research was convened to present and discuss current advances and future directions in ovarian cancer research. RESULTS: One session was dedicated to Tumor Microenvironment and Models of Ovarian Cancer, and included a keynote presentation from Anil Sood, MD, and an invited oral presentation from David Huntsman, MD...
October 18, 2017: International Journal of Gynecological Cancer
Ingo Ludolph, Marcus Lehnhardt, Andreas Arkudas, Ulrich Kneser, Gerhard Pierer, Yves Harder, Raymund E Horch
During the last two decades, understanding and experience of microsurgical reconstruction have increased. This is linked to improved instruments and technical devices, as well as to the increased number of available donor sites for microvascular flap transfer. If the indication is appropriate, it is now possible to perform personalised, safe and successful microsurgical reconstructions, almost independently of the patients' age. Despite these constant developments, there is little specific literature on microsurgery related to the specific problems of the elderly patient...
October 18, 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Ivica Letunic, Peer Bork
SMART (Simple Modular Architecture Research Tool) is a web resource ( for the identification and annotation of protein domains and the analysis of protein domain architectures. SMART version 8 contains manually curated models for more than 1300 protein domains, with approximately 100 new models added since our last update article (1). The underlying protein databases were synchronized with UniProt (2), Ensembl (3) and STRING (4), doubling the total number of annotated domains and other protein features to more than 200 million...
October 10, 2017: Nucleic Acids Research
Benjamin P Burke, Christopher Cawthorne, Stephen J Archibald
Molecular imaging, where the location of molecules or nanoscale constructs can be tracked in the body to report on disease or biochemical processes, is rapidly expanding to include combined modality or multimodal imaging. No single imaging technique can offer the optimum combination of properties (e.g. resolution, sensitivity, cost, availability). The rapid technological advances in hardware to scan patients, and software to process and fuse images, are pushing the boundaries of novel medical imaging approaches, and hand-in-hand with this is the requirement for advanced and specific multimodal imaging agents...
November 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Y Zhang, B R Lawn
Zirconias, the strongest of the dental ceramics, are increasingly being fabricated in monolithic form for a range of clinical applications. Y-TZP (yttria-stabilized tetragonal zirconia polycrystal) is the most widely used variant. However, current Y-TZP ceramics on the market lack the aesthetics of competitive glass-ceramics and are therefore somewhat restricted in the anterior region. This article reviews the progressive development of currently available and next-generation zirconias, representing a concerted drive toward greater translucency while preserving adequate strength and toughness...
October 1, 2017: Journal of Dental Research
Baptist Liefooghe, Senne Braem, Nachshon Meiran
Whereas psychology knows a long tradition of studies that focused on the role of practice and training in acquiring new skills or knowledge, systematic studies into learning via instructions remain relatively scarce. This is surprising given the tremendous influence instructions have on human behavior and cognition. In recent years, however, a (re)new(ed) interest into learning via instructions resulted in new paradigms and findings that can inspire future research in this understudied domain. We offer a brief overview of the articles in this special issue, which present some of the latest empirical developments dedicated to unraveling the implications and applications of learning via instructions...
October 12, 2017: Acta Psychologica
Ming Guo, Jun-He Shi, Pei-Li Wang, Da-Zhuo Shi
Although there have been advances in coronary artery bypass grafting and percutaneous coronary intervention, patients who have ischemic coronary artery disease (CAD) are ineligible for revascularization due to suboptimal anatomy. Cardiac angiogenesis is not only a physiological response to ischemia or hypoxia but also a potential target of therapeutic strategies. For some time now, preclinical studies show a great enthusiasm on therapeutic angiogenesis for ischemic CAD. However, the latest trials provided the limited evidence on its efficacy...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
D Kinlen, D Cody, D O'Shea
Global obesity rates have increased exponentially in recent decades. People are becoming obese younger, morbid obesity is increasing and the full health implications are only beginning to be seen. This article discusses the latest epidemiological data on obesity in adults and children, and systemically reviews the complications associated with the condition.
July 24, 2017: QJM: Monthly Journal of the Association of Physicians
Kassem Sharif, Vania Vieira Borba, Gisele Zandman-Goddard, Yehuda Shoenfeld
Ferritin, which was only discovered in the last century has stirred a formidable debate.. For long, Ferritin was appreciated as a non-specific acute phase reactant. Several years ago, we hypothesized the contributory role of ferritin as a pathogenic molecule rather than being a product of inflammation. Latest emerging evidence provide support to this notion. Such revelation provides a step forward toward the understanding of disease conditions associated with hyperferritenemia, and hence provide new targets for treatment modalities...
October 11, 2017: Clinical and Experimental Immunology
Hitoshi Gotoh, Akio Okayasu
For innovative designs of coastal structures, Numerical Wave Flumes (NWFs), which are solvers of Navier-Stokes equation for free-surface flows, are key tools. In this article, various methods and techniques for NWFs are overviewed. In the former half, key techniques of NWFs, namely the interface capturing (MAC, VOF, C-CUP) and significance of NWFs in comparison with the conventional wave models are described. In the latter part of this article, recent improvements of the particle method are shown as one of cores of NWFs...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Dominika Wcisło-Dziadecka, Martyna Zbiciak-Nylec, Ligia Brzezińska-Wcisło, Katarzyna Bebenek, Agata Kaźmierczak
The rapid progress of genetic engineering furthermore opens up new prospects in the therapy of this difficult-to-treat disease. IL-23 inhibitors, phosphodiesterase 4 (PDE4) inhibitors, and Janus kinase (JAK) inhibitors are currently encouraging further research. Two drugs which are IL-23 inhibitors are now in phase III of clinical trials. The aim of the action of both drugs is selective IL-23 inhibition by targeting the p19 subunit. Guselkumab is a fully human monoclonal antibody. Tildrakizumab is a humanized monoclonal antibody, which also belongs to IgG class and is targeted to subunit p19 of interleukin 23 (IL-23)...
October 10, 2017: Dermatologic Therapy
Richard I Walker, Thomas F Wierzba, Sachin Mani, A Louis Bourgeois
PATH hosted the inaugural Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference in Washington, DC in June 2016, bringing together experts from around the world for a highly collaborative forum to discuss progress in the development of new enteric vaccines. Diarrheal disease and long-term sequelae caused by infections with the bacterial pathogens Shigella and enterotoxigenic E. coli (ETEC) pose a significant public health burden in low-income communities. There are currently no licensed vaccines against these pathogens, and the global health community has recently prioritized their development...
October 4, 2017: Vaccine
Pankaj B Shah, Saji James, S Elayaraja
BACKGROUND: Febrile seizures can be classified as simple or complex. Complex febrile seizures are associated with fever that lasts longer than 15 minutes, occur more than once within 24 hours, and are confined to one side of the child's body. It is common in some countries for doctors to recommend an electroencephalograph (EEG) for children with complex febrile seizures. A limited evidence base is available to support the use of EEG and its timing after complex febrile seizures among children...
October 7, 2017: Cochrane Database of Systematic Reviews
Anushka M Wickramasuriya, Jim M Dunwell
Theobroma cacao - The Food of the Gods, provides the raw material for the multi-billion dollar chocolate industry, and is also the main source of income for about 6 million smallholders around the world. Additionally, cocoa beans have a number of other non-food uses in the pharmaceutical and cosmetic industries. Specifically, the potential health benefits of cocoa have received increasing attention as it is rich in polyphenols, particularly flavonoids. At present, the demand for cocoa and cocoa-based products in Asia is growing particularly rapidly and chocolate manufacturers are increasing investment in this region...
October 6, 2017: Plant Biotechnology Journal
Jakub Jończyk, Barbara Malawska, Marek Bajda
The crucial role of G-protein coupled receptors and the significant achievements associated with a better understanding of the spatial structure of known receptors in this family encouraged us to undertake a study on the histamine H3 receptor, whose crystal structure is still unresolved. The latest literature data and availability of different software enabled us to build homology models of higher accuracy than previously published ones. The new models are expected to be closer to crystal structures; and therefore, they are much more helpful in the design of potential ligands...
2017: PloS One
Vladimíra Datinská, Ivona Voráčová, Ulrich Schlecht, Jan Berka, František Foret
Progress achieved between 2014-2017 in the extraction and sample preparation of nucleic acid by isotachophoresis is reviewed in this paper. The isolation and purification of nucleic acids is very often compromised by a complex matrix such as blood and other bodily fluids, samples from the scene of crime, fossil samples, etc. While most of the common nucleic acids isolation techniques are based on extraction with inherent limitations with regard to quantitative results, isotachophoretic focusing is a quantitative process with a theoretically unlimited concentration factor...
October 5, 2017: Journal of Separation Science
W James Gauderman, Bhramar Mukherjee, Hugues Aschard, Li Hsu, Juan Pablo Lewinger, Chirag J Patel, John S Witte, Christopher Amos, Caroline G Tai, David Conti, Dara G Torgerson, Seunggeun Lee, Nilanjan Chatterjee
The analysis of gene-environment interaction (G×E) may hold the key for further understanding the etiology of many complex traits. The current availability of high-volume genetic data, the wide range in types of environmental data that can be measured, and the formation of consortiums of multiple studies provide new opportunities to identify G×E but also new analytical challenges. In this article, we summarize several statistical approaches that can be used to test for G×E in a genome-wide association study...
October 1, 2017: American Journal of Epidemiology
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