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https://www.readbyqxmd.com/read/28730760/targeted-therapy-with-anaplastic-lymphoma-kinase-inhibitors-in-non-small-cell-lung-cancer-even-with-brain-metastasis
#1
Bekir Muhammet Hacioglu, Osman Kostek, Bulent Erdogan, Sernaz Uzunoglu, Irfan Cicin
The incidence of brain metastases has increased as a result of improved systemic disease control and advances in imaging. Brain metastasis can occur approximately in 25-40% of the patients with non-small cell lung cancer (NSCLC) and it is a frequent cause of death. Stereotactic radiosurgery, whole-brain radiotherapy (WBRT) or surgical resection are the local treatment modalities for brain metastases which are feasible either alone, in combination, or as sequential treatments. Resistance to systemic therapy for brain metastasis poses significant clinical problems...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28729846/what-s-new-in-addiction-prevention-in-young-people-a-literature-review-of-the-last-years-of-research
#2
REVIEW
Cédric Kempf, Pierre-Michel Llorca, Frank Pizon, Georges Brousse, Valentin Flaudias
Rationale: Addiction prevention is a major public health problem, particularly concerning young people. Despite the consensus that primary prevention is essential, the evaluation of its impact is questioned. Objective: The objective of this paper is to assess the latest knowledge of addiction prevention programs for young people. Method: Review a collection of research articles using a keyword-based search on three databases: Pubmed, Eric, and PsycInfo. The research was carried out using three groups of keywords and the eligibility study was completed using two criteria: articles published between 2010 and 2017, and articles in refereed journals...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28721949/rising-to-the-challenge-applying-biofabrication-approaches-for-better-drug-and-chemical-product-development
#3
Anthony M Holmes, Alex Charlton, Brian Derby, Lorna Ewart, Andrew Scott, Wenmiao Shu
Many industrial sectors, from pharmaceuticals to consumer products, are required to provide data on their products to demonstrate their efficacy and that they are safe for patients, consumers and the environment. This period of testing typically requires the use of animal models, the validity of which has been called into question due to the high rates of attrition across many industries. There is increasing recognition of the limitations of animal models and demands for safety and efficacy testing paradigms which embrace the latest technological advances and knowledge of human biology...
July 19, 2017: Biofabrication
https://www.readbyqxmd.com/read/28721497/normoalbuminuric-diabetic-kidney-disease
#4
REVIEW
Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun
Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD). Early diagnosis is very important in preventing the development of DKD. Urinary albumin excretion rate (UAER) and glomerular filtration rate (GFR) are widely accepted as criteria for the diagnosis and clinical grading of DKD, and microalbuminuria has been recommended as the first clinical sign of DKD. The natural history of DKD has been divided into three stages: normoalbuminuria, microalbuminuria, and macroalbuminuria...
July 18, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/28721118/ophthalmoscopy-simulation-advances-in-training-and-practice-for-medical-students-and-young-ophthalmologists
#5
REVIEW
Lucas Holderegger Ricci, Caroline Amaral Ferraz
OBJECTIVE: To describe and appraise the latest simulation models for direct and indirect ophthalmoscopy as a learning tool in the medical field. METHODS: The present review was conducted using four national and international databases - PubMed, Scielo, Medline and Cochrane. Initial set of articles was screened based on title and abstracts, followed by full text analysis. It comprises of articles that were published in the past fifteen years (2002-2017). RESULTS: Eighty-three articles concerning simulation models for medical education were found in national and international databases, with only a few describing important aspects of ophthalmoscopy training and current application of simulation in medical education...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28720765/c-ebp%C3%AE-deregulation-as-a-paradigm-for-leukemogenesis
#6
REVIEW
J A Pulikkan, D G Tenen, G Behre
Myeloid master regulator CCAAT enhancer binding protein alpha (C/EBPα) is deregulated by multiple mechanisms in leukemia. Inhibition of C/EBPα function plays pivotal roles in leukemogenesis. While much is known about how C/EBPα orchestrates granulopoiesis, our understanding of molecular transformation events, the role(s) of cooperating mutations and clonal evolution during C/EBPα deregulation in leukemia remains elusive. In this review we will summarize the latest research addressing these topics with special emphasis on CEBPΑ mutations...
July 19, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28720635/increased-public-accountability-for-hospital-nonprofit-status-potential-impacts-on-residency-positions
#7
Melanie C Raffoul, Robert L Phillips
BACKGROUND: The Institute of Medicine recently called for greater graduate medical education (GME) accountability for meeting the workforce needs of the nation. The Affordable Care Act expanded community health needs assessment (CHNA) requirements for nonprofit and tax-exempt hospitals to include community assessment, intervention, and evaluation every 3 years but did not specify details about workforce. Texas receives relatively little federal GME funding but has used Medicaid waivers to support GME expansion...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28718911/clear-cell-renal-cell-carcinoma-validation-of-who-isup-grading
#8
Julien Dagher, Brett Delahunt, Nathalie Rioux-Leclercq, Lars Egevad, John R Srigley, Geoffrey Coughlin, Nigel Dunglinson, Troy Gianduzzo, Boon Kua, Greg Malone, Ben Martin, John Preston, Morgan Pokorny, Simon Wood, John Yaxley, Hemamali Samaratunga
AIM: In 2012, the International Society of Urological Pathology (ISUP) introduced a novel grading system for clear cell and papillary renal cell carcinoma (RCC) based upon increasing nucleolar prominence in grades 1 to 3, with the presence of extreme nuclear pleomorphism and/or tumour giant cells and/or sarcomatoid and/or rhabdoid differentiation as criteria for grade 4. This system is now incorporated in the latest World Health Organization renal tumour classification, being designated WHO/ISUP grading...
July 18, 2017: Histopathology
https://www.readbyqxmd.com/read/28714509/a-comparative-review-of-computational-methods-for-pathway-perturbation-analysis-dynamical-and-topological-perspectives
#9
REVIEW
Q Vanhaelen, A M Aliper, A Zhavoronkov
Stem cells offer great promise within the field of regenerative medicine but despite encouraging results, the large scale use of stem cells for therapeutic applications still faces challenges when it comes to controlling signaling pathway responses with respect to environmental perturbations. This step is critical for the elaboration of stable and reproducible differentiation protocols, and computational modeling can be helpful to overcome these difficulties. This article is a comparative review of the mechanism-based methods used for hypothesis-driven approaches and data-driven methods which are two types of computational approaches commonly used for analysing the dynamics of pathways involved in stem cell regulation...
July 17, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28713278/the-neuroanatomical-neurophysiological-and-psychological-basis-of-memory-current-models-and-their-origins
#10
REVIEW
Eduardo Camina, Francisco Güell
This review aims to classify and clarify, from a neuroanatomical, neurophysiological, and psychological perspective, different memory models that are currently widespread in the literature as well as to describe their origins. We believe it is important to consider previous developments without which one cannot adequately understand the kinds of models that are now current in the scientific literature. This article intends to provide a comprehensive and rigorous overview for understanding and ordering the latest scientific advances related to this subject...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28709678/annual-review-of-selected-scientific-literature-report-of-the-committee-on-scientific-investigation-of-the-american-academy-of-restorative-dentistry
#11
REVIEW
Terence E Donovan, Riccardo Marzola, Kevin R Murphy, David R Cagna, Frederick Eichmiller, James R McKee, James E Metz, Jean-Pierre Albouy, Mathias Troeltzsch
This review was conducted to assist the busy dentist in keeping abreast of the latest scientific information regarding the clinical practice of dentistry. Each of the authors, who are considered experts in their disciplines, was asked to peruse the scientific literature in their discipline published in 2016 and review the articles for important information that may affect treatment decisions. Comments on experimental methodology, statistical evaluation, and the overall validity of conclusions are included with many of the reviews...
July 11, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28704007/-blood-transfusion-optimizing-the-use-of-a-scarce-and-expensive-resource
#12
Omar Kherad
Haemoglobin transfusion threshold remains debated with a high variability of practice among physicians. Several well-conducted studies revealed that a liberal transfusion policy is not only unnecessary, but can also prove harmful in certain situations. Blood transfusion is a costly act involving risks of infection, allergic and hemodynamic. Optimizing the use of this scarce and expensive resource becomes necessary. This article summarizes the different transfusion thresholds to respect in hospital clinical practice, based on the latest international recommendations, while emphasizing the importance of clinical judgment in each situation...
January 25, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28703223/unmasking-the-molecular-link-between-arrhythmogenic-cardiomyopathy-and-brugada-syndrome
#13
REVIEW
Javier Moncayo-Arlandi, Ramon Brugada
The intercalated discs that connect cardiomyocytes control cell-to-cell adhesion and communication. Several macromolecular structures (desmosomes, fascia adherens junctions, gap junctions, and sodium-channel complexes) coexist in, and confer their mechanical and electrical properties to, the intercalated disc. Traditionally, each structure was assumed to have a unique function in the intercalated disc. However, growing evidence suggests that these complexes act together in intercellular communication and adhesion, forming a single structural and functional entity - the connexome...
July 13, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28701739/hypertension-with-diabetes-mellitus-significance-from-an-epidemiological-perspective-for-japanese
#14
Yukako Tatsumi, Takayoshi Ohkubo
The prevalence of both hypertension and diabetes mellitus is increasing worldwide. Both diseases lead to severe complications such as cardiovascular and chronic kidney diseases, which increase the risk of death over a long period of time. Therefore, the prevention and aggravation of hypertension and diabetes mellitus are major challenges. Because few review articles have focused on the epidemiological perspective of hypertension and diabetes mellitus, we reviewed major observational studies mainly from Japan and from Western countries that have reported on the prevalence of hypertension and diabetes mellitus, the binominal risk of hypertension and diabetes mellitus, and the risk of their coexistence...
July 13, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28699568/evaluation-of-the-informatician-perspective-determining-types-of-research-papers-preferred-by-clinicians
#15
Boshu Ru, Xiaoyan Wang, Lixia Yao
BACKGROUND: To deliver evidence-based medicine, clinicians often reference resources that are useful to their respective medical practices. Owing to their busy schedules, however, clinicians typically find it challenging to locate these relevant resources out of the rapidly growing number of journals and articles currently being published. The literature-recommender system may provide a possible solution to this issue if the individual needs of clinicians can be identified and applied...
July 5, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28697264/early-adversity-toxic-stress-and-resilience-pediatrics-for-today
#16
M Denise Dowd
Never before in the history of science have we had better insight into the factors that determine the health and well-being of a person from infancy to adulthood. An expanding body of knowledge is converging from numerous disciplines including neuroscience, education, behavioral science, public health, the social sciences, and medicine. Awareness of the impact of early childhood adversity and toxic stress is growing rapidly among both professionals and the lay public. This calls for a reevaluation of how and what we, as child health care providers, should deliver to maximize our impact on individual health and well-being across the lifespan...
July 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28695819/role-of-ultrasound-in-the-management-of-thyroid-nodules-and-thyroid-cancer
#17
Ruyu Liu, Bo Zhang
The management of thyroid nodules can be classified into narrow-and broad-sense levels. The broad-sense procedures are used for special population and include screening,risk assessment of thyroid nodules,follow-up of benign thyroid nodules,surgical operation,post-operative follow-up,and assessment and treatment of recurrence and/or metastasis of thyroid cancer. The narrow-sense procedures are for individual patients and the whole process includes the assessment,supervision,treatment,and reassessment of thyroid lesion...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28695243/cns-metabolism-in-high-risk-drug-abuse-insights-gained-from-1-h-31-p-mrs-and-pet
#18
REVIEW
S Bodea
BACKGROUND: High-risk drug consumption is a matter of great concern for public health actors in industrialised countries. The latest trends show a market tendency towards diversification and increasing demand for high-purity synthetic drugs. While most consumers seek medical help after cannabis use, it is high-risk drugs like cocaine, heroin and amphetamines that account for most of the 1000 drug-related deaths that occur in Germany every year. PURPOSE: This article presents the most prominent in vivo cerebral metabolic information in cocaine, heroin and methamphetamine users provided by MRI spectroscopy and PET imaging...
July 10, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28688020/salvage-therapy-options-for-local-prostate-cancer-recurrence-after-primary-radiotherapy-a-literature-review
#19
REVIEW
Nicole M Golbari, Aaron E Katz
PURPOSE OF REVIEW: While recurrence after primary treatment of prostate cancer (PCa) is not uncommon, there is currently no consensus on the most appropriate management after radiation treatment failure. This article seeks to explore the currently utilized modalities for salvage treatment for radiorecurrent PCa. We focused our review on the oncologic outcomes and reported toxicity rates in the latest studies examining salvage radical prostatectomy (SRP), salvage cryotherapy (SCT), salvage high-intensity focused ultrasound (HIFU) and re-irradiation...
August 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28685841/krebs-cycle-rewired-for-macrophage-and-dendritic-cell-effector-functions
#20
REVIEW
D G Ryan, L A O'Neill
The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. In response to pro-inflammatory stimuli, macrophages and dendritic cells undergo profound metabolic remodelling to support the biosynthetic and bioenergetic requirements of the cell. Recently it has been discovered that this metabolic shift also involves the rewiring of the Krebs cycle to regulate cellular metabolic flux and the accumulation of Krebs cycle intermediates, notably, citrate, succinate and fumarate...
July 7, 2017: FEBS Letters
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