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https://www.readbyqxmd.com/read/29755192/efficacy-and-pharmacokinetics-of-bupivacaine-with-epinephrine-or-dexmedetomidine-after-intraperitoneal-administration-in-cats-undergoing-ovariohysterectomy
#1
Javier Benito, Beatriz Monteiro, Francis Beaudry, Paulo Steagall
The aim of this study was to determine the efficacy and pharmacokinetics of bupivacaine in combination with epinephrine or dexmedetomidine after intraperitoneal administration in cats undergoing ovariohysterectomy. Sixteen healthy adult cats (3.3 ± 0.6 kg) were included in a prospective, randomized, masked clinical trial after obtaining owners' consent. Anesthetic protocol included buprenorphine-propofol-isoflurane. Meloxicam [0.2 mg/kg body weight (BW)] was administered subcutaneously before surgery. Cats were randomly divided into 2 groups to receive 1 of 2 treatments...
April 2018: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29754394/anesthesia-for-subcutaneous-implantable-cardioverter-defibrillator-implantation-perspectives-from-the-clinical-experience-of-a-us-panel-of-physicians
#2
Michael K Essandoh, George E Mark, Johan D Aasbo, Charles A Joyner, Saumya Sharma, Beningo F Decena, Eric D Bolin, Raul Weiss, Martin C Burke, Timothy R McClernon, Emile G Daoud, Michael R Gold
BACKGROUND AND OBJECTIVE: Worldwide adoption of the subcutaneous implantable cardioverter-defibrillator (S-ICD) for preventing sudden cardiac death continues to increase, as longer-term evidence demonstrating the safety and efficacy of the S-ICD expands. As a relatively new technology, comprehensive anesthesia guidance for the management of patients undergoing S-ICD placement is lacking. This article presents advantages and disadvantages of different peri-procedural sedation and anesthesia options for S-ICD implants including general anesthesia, monitored anesthesia care, regional anesthesia, and nonanesthesia personnel administered sedation and analgesia...
May 13, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29679880/subcutaneous-infiltration-of-doxylamine-on-cutaneous-analgesia-in-rats
#3
Ching-Hsia Hung, Ja-Ping Shieh, Chong-Chi Chiu, Jhi-Joung Wang, Yu-Wen Chen
BACKGROUND: We aimed to evaluate the effect of doxylamine, a first generation antihistamine, as a local analgesic agent by comparing its effect to bupivacaine. METHODS: After blocking the cutaneous trunci muscle reflex (CTMR) by subcutaneous injection of doxylamine, we assessed doxylamine's cutaneous analgesic effect in rats. The dose-related effect and duration of doxylamine on infiltrative cutaneous analgesia were compared with that of bupivacaine. RESULTS: We demonstrated that doxylamine, as well as the local anesthetic bupivacaine produced the cutaneous analgesic effects in a dose-related fashion...
December 20, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29673329/comparison-of-electroencephalographic-changes-in-response-to-acute-electrical-and-thermal-stimuli-with-the-tail-flick-and-hot-plate-test-in-rats-administered-with-opiorphin
#4
Preet Singh, Kavitha Kongara, David Harding, Neil Ward, Venkata Sayoji Rao Dukkipati, Craig Johnson, Paul Chambers
BACKGROUND: The objective of this study was to compare the changes in the electroencephalogram (EEG) in response to noxious stimuli with tail flick and hot plate responses of rats administered opiorphin. METHODS: Female Sprague -Dawley rats (n = 8 per group) randomly received intravenous (IV) injection of morphine (1 mg/kg,) or opiorphin (2 mg/kg,) or saline (0.5 ml,) in each of the three testing methods (EEG, tail flick and hot plate). Each type of test (n = 24 per test) was conducted in different population of rats on separate occasions...
April 19, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29627201/perioperative-analgesic-effects-of-an-ultrasound-guided-transversus-abdominis-plane-block-with-a-mixture-of-bupivacaine-and-lidocaine-in-cats-undergoing-ovariectomy
#5
Despoina Skouropoulou, Luca Lacitignola, Paola Centonze, Angela Simone, Alberto M Crovace, Francesco Staffieri
OBJECTIVE: To evaluate the perioperative analgesic effects of a transversus abdominis plane (TAP) block with a mixture of lidocaine and bupivacaine administered to cats undergoing ovariectomy. STUDY DESIGN: Controlled, randomized, prospective, blinded clinical study. ANIMALS: A group of 20 healthy cats. METHODS: Robenacoxib (2 mg kg-1 ) was administered subcutaneously 0.5 hour before intramuscular (IM) administration of ketamine (5 mg kg-1 ), methadone (0...
February 3, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29619074/involvement-of-mrgprc-in-electroacupuncture-analgesia-for-attenuating-cfa-induced-thermal-hyperalgesia-by-suppressing-the-trpv1-pathway
#6
Ying-Jun Liu, Xiao-Xi Lin, Jian-Qiao Fang, Fang Fang
Mas-related G-protein-coupled receptor C (MrgprC) plays an important role in modulating chronic inflammatory pain. Electroacupuncture (EA) has a satisfactory analgesic effect on chronic pain. This study aimed to investigate the involvement of MrgprC and its transient receptor potential vanilloid 1 (TRPV1) pathway in EA analgesia in chronic inflammatory pain. Chronic inflammatory pain was induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the left hind paw. EA (2/100 Hz) stimulation was administered...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29562618/transdermal-and-topical-drug-administration-in-the-treatment-of-pain
#7
REVIEW
Wojciech Leppert, Malgorzata Malec-Milewska, Renata Zajaczkowska, Jerzy Wordliczek
The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients' age, comorbidities, and appropriate choice of analgesic, its dose and route of administration. This review is aimed at presenting current knowledge on analgesics administered by transdermal and topical routes for physicians, nurses, pharmacists, and other health care professionals dealing with patients suffering from pain. Analgesics administered transdermally or topically act through different mechanisms...
March 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29559326/canadian-trends-in-carpal-tunnel-surgery
#8
Blair Peters, Jennifer L Giuffre
PURPOSE: Treatment patterns of carpal tunnel surgery by members of the American Society of Surgery of the Hand (ASSH) have recently been published. The majority of cases in this study were performed in the general operating room with intravenous (IV) sedation or a Bier block. Patients were most commonly prescribed hydrocodone for postoperative pain. The majority of carpal tunnel releases at our center are performed under local anesthesia alone, with plain acetaminophen (Tylenol) or codeine prescribed for postoperative pain...
March 17, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29529915/combining-ultrasound-guided-vascular-access-with-ultrasound-guided-analgesia-for-single-skin-and-vessel-puncture
#9
Timothy E Murray, Damien C O'Neill, Michael J Lee
PURPOSE: To describe a single skin puncture technique combining subcutaneous injection of anesthetic to the depth of the vessel wall with venipuncture in the same movement. TECHNIQUE: Using ultrasound guidance, controlled anesthetic instillation along the needle tract and outer vessel wall with a 21-G vascular access needle can be combined with vessel puncture. This technique reduces the number of skin punctures and ensures accurate anesthetic instillation. The maximum inadvertent intravascular dose of commercial local anesthetic preparations that can be delivered with a small syringe is far below toxicity thresholds...
March 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29521421/the-pharmacokinetics-and-analgesic-effects-of-extended-release-buprenorphine-administered-subcutaneously-in-healthy-dogs
#10
M Barletta, S M Ostenkamp, A C Taylor, J Quandt, B D X Lascelles, K M Messenger
Buprenorphine is a partial μ agonist opioid used for analgesia in dogs. An extended-release formulation (ER-buprenorphine) has been shown to provide effective analgesia for 72 hr in rats and mice. Six healthy mongrel dogs were enrolled in a randomized, blinded crossover design to describe and compare the pharmacokinetics and pharmacodynamics of ER-buprenorphine administered subcutaneous at 0.2 mg/kg (ER-B) and commercially available buprenorphine for injection intravenously at 0.02 mg/kg (IV-B). After drug administration, serial blood samples were collected to measure plasma buprenorphine concentrations using liquid chromatography/mass spectrometry detection...
March 9, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29516968/clinical-analysis-of-electroacupuncture-and-multiple-acupoint-stimulation-in-relieving-cancer-pain-in-patients-with-advanced-hepatocellular-carcinoma
#11
Lili Xu, Yongxian Wan, Juan Huang, Fangyuan Xu
Objective: The objective of this study is to investigate the clinical efficacy and safety of electroacupuncture and multiple acupoint stimulation in relieving cancer pain in patients with advanced hepatocellular carcinoma. Methods: Sixty-five cases of advanced hepatocellular carcinoma with cancer pain were selected in our hospital and were divided into electroacupuncture multiple acupoint stimulation group (electroacupuncture group) (n = 32) and fentanyl transdermal patch analgesia group (control group) (n = 33) according to analgesic methods and intentions...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29516407/local-sustained-delivery-of-bupivacaine-hcl-from-a-new-castor-oil-based-nanoemulsion-system
#12
Heni Rachmawati, Yang Aryani Arvin, Sukmadjaja Asyarie, Kusnandar Anggadiredja, Raymond Rubianto Tjandrawinata, Gert Storm
Bupivacaine HCl (1-butyl-2',6'-pipecoloxylidide hydrochloride), an amide local anesthetic compound, is a local anesthetic drug utilized for intraoperative local anesthesia, post-operative analgesia and in the treatment of chronic pain. However, its utility is limited by the relative short duration of analgesia after local administration (approximately 9 h after direct injection) and risk for side effects. This work is aimed to develop a nanoemulsion of bupivacaine HCl with sustained local anesthetics release kinetics for improved pain management, by exhibiting extended analgesic action and providing reduced peak levels in the circulation to minimize side effects...
June 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29512795/inhaled-nitrous-oxide-during-the-make-stitches-randomized-double-blind-prospective-study
#13
Chawki Jebali, Lotfi Boukadida, Ali Ousgi, Wael Chaabene, Borhen Shili, Mohamed Amin Naggara, Riadh Boukef
INTRODUCTION: Inhaled nitrous oxide (MEOPA) ensures short-term analgesia of a patient in spontaneous ventilation through a mask. It ensures analgesic coverage during the painful gesture while saving to the patient the phenomena of memorization. AIM: To study the efficacy and safety of the use of MEOPA during the make stitches. METHODS: Randomized double blind prospective study including any patient aged > 16 years admitted to the emergency for make stitches during a period of 3 months...
June 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/29503687/does-subcutaneous-infiltration-of-liposomal-bupivacaine-following-single-level-transforaminal-lumbar-interbody-fusion-surgery-improve-immediate-postoperative-pain-control
#14
Marko Tomov, Kevin Tou, Rose Winkel, Ross Puffer, Mohamad Bydon, Ahmad Nassr, Paul Huddleston, Michael Yaszemski, Bradford Currier, Brett Freedman
Study Design: Retrospective case-control study using prospectively collected data. Purpose: Evaluate the impact of liposomal bupivacaine (LB) on postoperative pain management and narcotic use following standardized single-level low lumbar transforaminal lumbar interbody fusion (TLIF). Overview of Literature: Poor pain control after surgery has been linked with decreased pain satisfaction and increased economic burden. Unfortunately, opioids have many limitations and side effects despite being the primary treatment of postoperative pain...
February 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/29493802/ultrasound-guided-serratus-anterior-plane-block-combined-with-the-two-incision-technique-for-subcutaneous-icd-implantation
#15
Andrea Droghetti, Erika Basso Ricci, Paolo Scimia, Fabiola Harizai, Massimiliano Marini
BACKGROUND: The standard technique for implanting a subcutaneous implantable cardioverter defibrillator (S-ICD) requires three incisions and the pocket of the device is created in the subcutaneous tissue of the left lateral thoracic wall. However, a two-incision technique may be adopted, in which the cranial parasternal region is avoided and the device is positioned more deeply, completely under the latissimus dorsi muscle. This can also be combined with ultrasound-guided serratus anterior plane block (US-SAPB) for intraoperative anesthesia and perioperative analgesia...
March 1, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29448876/evaluation-of-injectable-anaesthesia-with-five-medetomidine-midazolam-based-combinations-in-egyptian-fruit-bats-rousettus-aegyptiacus
#16
Avishag Tuval, Liora Las, Yael Shilo-Benjamini
Egyptian fruit bats are increasingly used as model animals in neuroscience research. Our aim was to characterize suitable injectable anaesthesia for this species, possibly replacing inhalant anaesthesia, thus minimizing occupational health hazards. Eight bats were randomly assigned by a crossover design for subcutaneously administered combinations of medetomidine-midazolam with: saline (MM-Sal), ketamine (MM-Ket), fentanyl (MM-Fen), morphine (MM-Mor), or butorphanol (MM-But). The anaesthetic depth and vital signs were monitored at baseline and every 10 min until bats recovered...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29425797/antinociceptive-effects-of-the-endogenous-cannabinoid-peptide-agonist-vd-hemopressin-%C3%AE-in-mice
#17
Pei Wang, Ting Zheng, Mengna Zhang, Biao Xu, Run Zhang, Ting Zhang, Weidong Zhao, Xuerui Shi, Qinqin Zhang, Quan Fang
Cannabinoids (CBs) play important roles in pain modulation. Recently, VD-hemopressin(β) [VD-Hpβ], a 12-residue β-hemoglobin-derived peptide, was reported to activate both CB1 and CB2 receptors in vitro. To further characterize in vivo actions of VD-Hpβ, its antinociceptive activity and site(s) were evaluated in the mouse tail-flick test, and supraspinal antinociception of VD-Hpβ was further assessed in the writhing test. Our results demonstrated that supraspinal, intrathecal, subcutaneous and intraperitoneal administrations of VD-Hpβ produced analgesia in the tail-flick test...
February 6, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29414895/a-case-of-spontaneous-pneumomediastinum-with-subcutaneous-emphysema-in-children
#18
Said Benlamkaddem, Mohamed Adnane Berdai, Smael Labib, Mustapha Harandou
Spontaneous pneumomediastinum is defined as free air or gas contained within the mediastinum, which almost invariably originates from the alveolar space or the conducting airways. It is rare in pediatric patients; however, occasional cases are reported to result from forced Valsalva's maneuver due to cough, emesis, a first attack of wheeze, or asthma exacerbations. We report the case of a 7-year-old previously healthy girl, with a history of persistent dry cough one day before, who was brought to our unit with face, neck and chest swelling...
February 7, 2018: Children
https://www.readbyqxmd.com/read/29361312/the-usefulness-of-interpectoral-block-as-an-analgesic-technique-in-breast-cancer-surgery
#19
R Ortiz de la Tabla González, P Gómez Reja, D Moreno Rey, C Pérez Naranjo, I Sánchez Martín, M Echevarría Moreno
OBJECTIVE: To compare the analgesic efficacy of continuous interpectoral block (CIPB) compared to intravenous analgesia (IV) after breast surgery. MATERIAL AND METHOD: A prospective, comparative and randomised study of women aged from 18-75years, ASAI-III, operated for breast cancer. In group1 (CIPB) after general anaesthetic, an ultrasound-guided interpectoral catheter was placed and 30mL of 0.5% ropivacaine was administered through it. In the event of an increase in heart rate and blood pressure >15% after the surgical incision, intravenous fentanyl 1μg·kg-1 was administered, repeating the dose as necessary...
April 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29284853/comparison-of-local-wound-infiltration-with-ropivacaine-alone-or-ropivacaine-plus-dexmedetomidine-for-postoperative-pain-relief-after-lower-segment-cesarean-section
#20
Shaman Bhardwaj, Sumeet Devgan, Dinesh Sood, Sunil Katyal
Context: Dexmedetomidine, α2 -adrenergic agonist, when coadministered with local anesthetics, improves the speed of onset, duration of analgesia and decreases the dose of local anesthetic used. Aims: The aim of this study was to compare the efficacy of local subcutaneous wound infiltration of ropivacaine alone with ropivacaine plus dexmedetomidine for postoperative pain relief following lower segment cesarean section (LSCS). Subjects and Methods: The study was a prospective, randomized control, double-blind study...
October 2017: Anesthesia, Essays and Researches
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