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https://www.readbyqxmd.com/read/28717702/management-of-chemoradiation-induced-mucositis-in-head-and-neck-cancers-with-oral-glutamine
#1
Lucy Pattanayak, Niharika Panda, Manoj Kumar Dash, Sumita Mohanty, Sagarika Samantaray
PURPOSE: Head and neck cancers are the third most common cancers worldwide. Oral mucositis is the most common toxicity seen in patients who receive chemoradiation to treat head and neck cancer. The aim of this study was to evaluate the efficacy and safety of oral glutamine supplementation in these patients. MATERIALS AND METHODS: From December 2013 to December 2014, we randomly assigned to two arms 162 patients who had squamous cell carcinoma of the head and neck...
August 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716950/analysis-of-small-critical-regions-of-swi1-conferring-prion-formation-maintenance-and-transmission
#2
Stephanie Valtierra, Zhiqiang Du, Liming Li
Saccharomyces cerevisiae contains several prion elements, which are epigenetically transmitted as self-perpetuating protein conformations. One such prion is [SWI(+) ], whose protein determinant is Swi1, a subunit of the SWI/SNF chromatin-remodeling complex. We previously reported that [SWI(+) ] formation results in a partial loss-of-function phenotype of poor growth in non-glucose media and abolishment of multicellularity. We also showed that the first 38 amino acids of Swi1 propagated [SWI(+)]. We show here that a region as small as the first 32 amino acids of Swi1 (Swi11-32) can decorate [SWI(+)] aggregation and stably maintain and transmit [SWI(+)] independently of full-length Swi1...
July 17, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28716540/developmental-vitamin-d-deficiency-alters-multiple-neurotransmitter-systems-in-the-neonatal-rat-brain
#3
James P Kesby, Karly Turner, Suzanne Alexander, Darryl W Eyles, John J McGrath, Thomas H J Burne
BACKGROUND: Epidemiological evidence suggests that developmental vitamin D (DVD) deficiency is a risk factor for neuropsychiatric disorders, such as schizophrenia. DVD deficiency in rats is associated with altered brain structure and adult behaviours indicating alterations in dopamine and glutamate signalling. Developmental alterations in dopamine neurotransmission have also been observed in DVD-deficient rats but a comprehensive assessment of brain neurochemistry has not been undertaken...
July 14, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28715746/pfoa-induced-metabolism-disturbance-and-multi-generational-reproductive-toxicity-in-oryzias-latipes
#4
Jin Wuk Lee, Jae-Woo Lee, Kyungtae Kim, Yu-Jin Shin, Jieun Kim, Suhkmann Kim, Heejung Kim, Pilje Kim, Kyunghwa Park
The aims of this study were to examine multi-generational reproductive toxicity and metabolism disturbances in Oryzias latipes exposed to 0.3, 3, and 30mg/L PFOA for 259-day. The highest concentration of PFOA suppressed fecundity over three generations from F0 to F2 and sac-fry survival rate in F2 generation, indicating that PFOA resulted in multi-generational reproductive toxicity (p<0.05). Histologically, in F1 and F2 generations, O. latipes exposed to 30mg/L PFOA revealed accelerated gonad development, and the atrophy and degeneration of thyroid follicular cell...
June 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28714978/%C3%AE-ketoglutarate-orchestrates-macrophage-activation-through-metabolic-and-epigenetic-reprogramming
#5
Pu-Ste Liu, Haiping Wang, Xiaoyun Li, Tung Chao, Tony Teav, Stefan Christen, Giusy Di Conza, Wan-Chen Cheng, Chih-Hung Chou, Magdalena Vavakova, Charlotte Muret, Koen Debackere, Massimiliano Mazzone, Hsien-Da Huang, Sarah-Maria Fendt, Julijana Ivanisevic, Ping-Chih Ho
Glutamine metabolism provides synergistic support for macrophage activation and elicitation of desirable immune responses; however, the underlying mechanisms regulated by glutamine metabolism to orchestrate macrophage activation remain unclear. Here we show that the production of α-ketoglutarate (αKG) via glutaminolysis is important for alternative (M2) activation of macrophages, including engagement of fatty acid oxidation (FAO) and Jmjd3-dependent epigenetic reprogramming of M2 genes. This M2-promoting mechanism is further modulated by a high αKG/succinate ratio, whereas a low ratio strengthens the proinflammatory phenotype in classically activated (M1) macrophages...
July 17, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28713710/the-healing-effect-of-conditioned-media-and-bone-marrow-derived-stem-cells-in-laryngotracheal-stenosis-a-comparison-in-experimental-dog-model
#6
Kamyar Iravani, Arash Sobhanmanesh, Mohammad Javad Ashraf, Seyed Basir Hashemi, Davood Mehrabani, Shahrokh Zare
BACKGROUND: Differences in causes, severities, areas of stenosis, and the association with swallowing and phonation of larynx and trachea can result into Laryngotracheal stenosis (LTS).This study evaluated the healing effect of bone marrow stem cells (BMSCs) in experimentally induced LTS dog model. METHODS: Seven dogs were enrolled. BMSCs were isolated from proximal humerus and shoulder of a dog and cultured in media containing alpha minimal essential medium, fetal bovine serum, penicillin and streptomycin, and L-glutamine...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28713382/recent-advances-on-nutrition-in-treatment-of-acute-pancreatitis
#7
REVIEW
Li-Long Pan, Jiahong Li, Muhammad Shamoon, Madhav Bhatia, Jia Sun
Acute pancreatitis (AP) is a common abdominal acute inflammatory disorder and the leading cause of hospital admission for gastrointestinal disorders in many countries. Clinical manifestations of AP vary from self-limiting local inflammation to devastating systemic pathological conditions causing significant morbidity and mortality. To date, despite extensive efforts in translating promising experimental therapeutic targets in clinical trials, disease-specific effective remedy remains obscure, and supportive care has still been the primary treatment for this disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28712890/amburana-cearensis-seed-extract-protects-brain-mitochondria-from-oxidative-stress-and-cerebellar-cells-from-excitotoxicity-induced-by-glutamate
#8
E P L Pereira, C S Santos, J Amparo, R Short, Y Nuñez-Figueredo, L G Fernandez, P R Ribeiro, S Braga-de-Souza, V D A Silva, S L Costa
ETHNOPHARMACOLOGICAL RELEVANCE: Amburana cearensis (Allemao) A.C.Sm. is a medicinal plant of the Brazilian Caatinga reported to present antioxidant and anti-inflammatory activity. This study aimed to evaluate the neuroprotective effect of the extracts obtained from the seeds of A. cearensis in primary cultures of cerebellar cells subjected to excitotoxicity induced by glutamate and brain mitochondria submitted to oxidative stress. MATERIALS: and methods: Primary cultures of cerebellar cells were treated with the ethanol (ETAC), hexane (EHAC), dichloromethane (EDAC) and ethyl acetate (EAAC) extracts of the seeds of A...
July 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28712602/anaplerotic-therapy-in-propionic-acidemia
#9
Nicola Longo, Leisa B Price, Eduard Gappmaier, Nancy L Cantor, Sharon L Ernst, Carrie Bailey, Marzia Pasquali
BACKGROUND: Propionic acidemia is a rare metabolic disorder caused by a deficiency of propionyl- CoA carboxylase, the enzyme converting propionyl-CoA to methylmalonyl-CoA that subsequently enters the citric acid cycle as succinyl-CoA. Patients with propionic acidemia cannot metabolize propionic acid, which combines with oxaloacetate to form methylcitric acid. This, with the defective supply of succinyl-CoA, may lead to a deficiency in citric acid cycle intermediates. PURPOSE: The objective of this study was to determine whether supplements with glutamine (400mg/kg per day), citrate (7...
July 12, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28712002/mutations-in-gfpt1-related-congenital-myasthenic-syndromes-are-associated-with-synaptic-morphological-defects-and-underlie-a-tubular-aggregate-myopathy-with-synaptopathy
#10
Stéphanie Bauché, Geoffroy Vellieux, Damien Sternberg, Marie-Joséphine Fontenille, Elodie De Bruyckere, Claire-Sophie Davoine, Guy Brochier, Julien Messéant, Lucie Wolf, Michel Fardeau, Emmanuelle Lacène, Norma Romero, Jeanine Koenig, Emmanuel Fournier, Daniel Hantaï, Nathalie Streichenberger, Veronique Manel, Arnaud Lacour, Aleksandra Nadaj-Pakleza, Sylvie Sukno, Françoise Bouhour, Pascal Laforêt, Bertrand Fontaine, Laure Strochlic, Bruno Eymard, Frédéric Chevessier, Tanya Stojkovic, Sophie Nicole
Mutations in GFPT1 (glutamine-fructose-6-phosphate transaminase 1), a gene encoding an enzyme involved in glycosylation of ubiquitous proteins, cause a limb-girdle congenital myasthenic syndrome (LG-CMS) with tubular aggregates (TAs) characterized predominantly by affection of the proximal skeletal muscles and presence of highly organized and remodeled sarcoplasmic tubules in patients' muscle biopsies. We report here the first long-term clinical follow-up of 11 French individuals suffering from LG-CMS with TAs due to GFPT1 mutations, of which nine are new...
July 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28711496/metabolomic-profiling-reveals-potential-biomarkers-in-esophageal-cancer-progression-using-liquid-chromatography-mass-spectrometry-platform
#11
Haiping Zhang, Lei Wang, Zhichao Hou, Hong Ma, Batur Mamtimin, Ayshamgul Hasim, Ilyar Sheyhidin
Esophageal cancer (EC) is one of the most common malignancies with poor prognosis. Metabolomics has been shown to be a powerful approach to discover the potential biomarkers for cancer diagnosis and prognosis. The goal of this study is to screen potential biomarkers for early diagnosis and prognosis. In this study, 40 tissue samples and the corresponding control samples from the same esophageal squamous cell carcinoma (ESCC) patients were analyzed by liquid chromatography-mass spectrometry (LC-MS)-based metabolomics...
July 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28705740/proteomics-analysis-of-human-placenta-reveals-glutathione-metabolism-dysfunction-as-the-underlying-pathogenesis-for-preeclampsia
#12
Xiaohan Jin, Zhongwei Xu, Jin Cao, Ping Shao, Maobin Zhou, Zhe Qin, Yan Liu, Fang Yu, Xin Zhou, Wenjie Ji, Wei Cai, Yongqiang Ma, Chengyan Wang, Nana Shan, Ning Yang, Xu Chen, Yuming Li
Hypertensive disorder in pregnancy (HDP) refers to a series of diseases that cause the hypertension during pregnancy, including HDP, preeclampsia (PE) and eclampsia. This study screens differentially expressed proteins of placenta tissues in PE cases using 2D LC-MS/MS quantitative proteomics strategy. A total of 2281 proteins are quantified, of these, 145 altering expression proteins are successfully screened between PE and control cases (p<0.05). Bioinformatics analysis suggests that these proteins are mainly involved in many biological processes, such as oxidation reduction, mitochondrion organization, and acute inflammatory response...
July 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28704361/from-krebs-to-clinic-glutamine-metabolism-to-cancer-therapy
#13
Brian J Altman, Zachary E Stine, Chi V Dang
No abstract text is available yet for this article.
November 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28704359/from-krebs-to-clinic-glutamine-metabolism-to-cancer-therapy
#14
Brian J Altman, Zachary E Stine, Chi V Dang
No abstract text is available yet for this article.
December 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28701731/bloc-1-deficiency-causes-alterations-in-amino-acid-profile-and-in-phospholipid-and-adenosine-metabolism-in-the-postnatal-mouse-hippocampus
#15
S M van Liempd, D Cabrera, F Y Lee, E González, E C Dell'Angelica, C A Ghiani, J M Falcon-Perez
Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a protein complex involved in the formation of endosomal tubular structures that mediates the sorting of protein cargoes to specialised compartments. In this study, we present insights into the metabolic consequences caused by BLOC-1 deficiency in pallid mice, which carry a null mutation in the Bloc1s6 gene encoding an essential component of this complex. The metabolome of the hippocampus of pallid mice was analysed using an untargeted, liquid chromatography-coupled mass spectrometric approach...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701145/an-in-vitro-technique-to-identify-the-rna-binding-site-sequences-for-rna-binding-proteins
#16
SunKyung Choi, Chungoo Park, Kyoon Eon Kim, Kee K Kim
RNA-protein interactions play a major role in gene regulation. Although many techniques to analyze RNA-protein interactions have been developed, noteworthy challenges such as determining the RNA sequences that bind RNA-binding proteins (RBPs) remain unsolved. Here, we describe a novel technique using a 4-thio-uridine-incorporated RNA pool to identify the RBP-binding consensus sequences for RBPs produced by in vitro transcription and translation. To confirm the fidelity of this approach, we determined the consensus RBP-binding sequence for RBFOX2, UGC(A/U)(A/U)NU, which is very similar to the known RBFOX2-binding sequence, UGCAUG...
July 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28700727/longitudinal-increases-of-brain-metabolite-levels-in-5-10-year-old-children
#17
Martha J Holmes, Frances C Robertson, Francesca Little, Steven R Randall, Mark F Cotton, Andre J W van der Kouwe, Barbara Laughton, Ernesta M Meintjes
Longitudinal magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) studies reveal significant changes in brain structure and structural networks that occur together with cognitive and behavioral maturation in childhood. However, the underlying cellular changes accompanying brain maturation are less understood. Examining regional age-related changes in metabolite levels provides insight into the physiology of neurodevelopment. Magnetic resonance spectroscopy (MRS) measures localize brain metabolism...
2017: PloS One
https://www.readbyqxmd.com/read/28700616/natural-variation-in-a-single-amino-acid-substitution-underlies-physiological-responses-to-topoisomerase-ii-poisons
#18
Stefan Zdraljevic, Christine Strand, Hannah S Seidel, Daniel E Cook, John G Doench, Erik C Andersen
Many chemotherapeutic drugs are differentially effective from one patient to the next. Understanding the causes of this variability is a critical step towards the development of personalized treatments and improvements to existing medications. Here, we investigate sensitivity to a group of anti-neoplastic drugs that target topoisomerase II using the model organism Caenorhabditis elegans. We show that wild strains of C. elegans vary in their sensitivity to these drugs, and we use an unbiased genetic approach to demonstrate that this natural variation is explained by a methionine-to-glutamine substitution in topoisomerase II (TOP-2)...
July 12, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28698568/an-allelic-variant-of-the-pmrb-sensor-kinase-responsible-for-colistin-resistance-in-an-escherichia-coli-strain-of-clinical-origin
#19
Antonio Cannatelli, Tommaso Giani, Noemi Aiezza, Vincenzo Di Pilato, Luigi Principe, Francesco Luzzaro, Cesira L Galeotti, Gian Maria Rossolini
We investigated the colistin resistance mechanism in an Escherichia coli strain (LC711/14) isolated in Italy in 2014, from an urinary tract infection, which was previously shown to express a colistin resistance mechanism different from mcr-1. LC711/14 was found to carry a novel mutation in the pmrB gene, resulting in a leucine to proline amino acid substitution at position 10 of the PmrB sensor kinase component of the PmrAB signal transduction system. The role of this substitution in colistin resistance was documented by expression of the wild-type and mutated alleles in a pmrB deletion derivative of the E...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28697427/nmr-based-metabolomic-study-on-the-toxicological-effects-of-pesticide-diazinon-on-adaptation-to-sea-water-by-endangered-persian-sturgeon-acipenser-persicus-fingerlings
#20
Saeed Hajirezaee, Alireza Mirvaghefi, Hamid Farahmand, Naser Agh
NMR-based metabolomics was applied to explore metabolic impacts of diazinon on sea water adaptation of Persian sturgeon fingerlings, Acipenser persicus. Fingerlings were exposed to sub-lethal concentrations of diazinon in freshwater (FW) for 96 h (short-term trial) and 12 days (long-term trial) and then exposed in brackish water (BW) (12 mg L(-1) salinity) for 24 h. After 96 h and 12 days exposure in FW, identified metabolites (amino acids, osmolytes, energy metabolites) showed different change-patterns compared to control group (P < 0...
July 4, 2017: Chemosphere
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