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pyelonephritis acute in children

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https://www.readbyqxmd.com/read/29789888/diffusion-tensor-imaging-in-acute-pyelonephritis-in-children
#1
Mickaël Lair, Mariette Renaux-Petel, Adnan Hassani, Yohann Cruypeninck, Ioana Vasies, Agnès Liard, Jean-Nicolas Dacher, Pierre-Hugues Vivier
BACKGROUND: Diffusion-weighted imaging plays a key role in the imaging of acute pyelonephritis by MRI. However the use of respiratory triggering is challenging and time-consuming in children. Diffusion tensor imaging without respiratory triggering might provide satisfying images of the moving kidneys. OBJECTIVE: To compare mean diffusivity diffusion tensor images obtained with free breathing with diffusion-weighted images obtained with respiratory triggering. MATERIALS AND METHODS: Thirty-one children with suspected acute pyelonephritis underwent axial diffusion tensor imaging acquisition with free breathing and axial and coronal diffusion-weighted imaging acquisitions with respiratory triggering...
May 22, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29778699/re-diffusion-weighted-magnetic-resonance-imaging-is-more-sensitive-than-dimercaptosuccinic-acid-scintigraphy-in-detecting-parenchymal-lesions-in-children-with-acute-pyelonephritis-a-prospective-study
#2
https://www.readbyqxmd.com/read/29736094/influence-of-plasminogen-activator-inhibitor-1-gene-polymorphism-on-renal-scarring-after-first-febrile-urinary-tract-infection-in-infants
#3
Danka Pokrajac, Lejla Kapur-Pojskic, Sandra Vegar-Zubovic, Renata Milardovic
Background: The pathogenesis of renal scarring (RS) after first febrile urinary tract infection (UTI) in children is multifactorial. In addition to well-known risk factors, a role for genetic predisposition has been suggested. Aims: To determine whether deoxyribonucleic acid (DNA) polymorphisms at the plasminogen activator inhibitor -1 (PAI-1) gene were associated with evolution to RS following a febrile UTI in infants. Materials and Methods: Our research included 100 infants, 84 girls and 16 boys, ages up to 1 year with a first febrile UTI, increased inflammatory parameters and positive urine culture treated at the Pediatric Clinic II of the University Clinical Center Sarajevo (UCCS)...
April 2018: Medical Archives
https://www.readbyqxmd.com/read/29691919/impact-of-different-assumptions-on-estimates-of-childhood-diseases-obtained-from-health-care-data-a-retrospective-cohort-study
#4
Osemeke U Osokogu, Alexandra Pacurariu, Mees Mosseveld, Peter Rijnbeek, Daniel Weibel, Katia Verhamme, Miriam C J M Sturkenboom
PURPOSE: Accurate estimates of disease incidence in children are required to support pediatric drug development. Analysis of electronic health care records (EHR) may yield such estimates but pediatric-specific methods are lacking. We aimed to understand the impact of assumptions regarding duration of disease episode and length of run-in period on incidence estimates from EHRs. METHODS: Children aged 0 to 17 years (5-17 years for asthma) registered in the Integrated Primary Care Information database between 2002 and 2014 were studied...
April 24, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29600927/-a-child-with-abdominal-pain-and-fever-consider-acute-lobar-nephritis-diagnostic-considerations-when-the-appendix-is-invisible-on-ultrasound
#5
A M Bakker, G H E J Vijgen, N G Hartwig, G A Tramper-Stranders
Acute lobar nephritis (ALN) is a focal interstitial bacterial infection of the renal parenchyma. ALN is described as a midpoint between an acute pyelonephritis and renal abscess. ALN is underdiagnosed in children due to both non-specific symptoms and negative urinalysis/bacteriuria laboratory findings. The gold standard for diagnosis of ALN is CT scanning, however MRI can be considered to avoid radiation exposure. Diagnosing ALN is relevant, because it requires prolonged antibiotic treatment. Insufficient antibiotic treatment could cause renal scarring and subsequent hypertension or renal failure...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29590188/overview-of-systematic-reviews-assessing-the-evidence-for-shorter-versus-longer-duration-antibiotic-treatment-for-bacterial-infections-in-secondary-care
#6
Igho J Onakpoya, A Sarah Walker, Pui S Tan, Elizabeth A Spencer, Oghenekome A Gbinigie, Johanna Cook, Martin J Llewelyn, Christopher C Butler
Our objective was to assess the clinical effectiveness of shorter versus longer duration antibiotics for treatment of bacterial infections in adults and children in secondary care settings, using the evidence from published systematic reviews. We conducted electronic searches in MEDLINE, Embase, Cochrane, and Cinahl. Our primary outcome was clinical resolution. The quality of included reviews was assessed using the AMSTAR criteria, and the quality of the evidence was rated using the GRADE criteria. We included 6 systematic reviews (n = 3,162)...
2018: PloS One
https://www.readbyqxmd.com/read/29588142/diffusion-weighted-magnetic-resonance-imaging-is-more-sensitive-than-dimercaptosuccinic-acid-scintigraphy-in-detecting-parenchymal-lesions-in-children-with-acute-pyelonephritis-a-prospective-study
#7
Alice Bosakova, Dana Salounova, Jaroslav Havelka, Otakar Kraft, Pavel Sirucek, Radim Kocvara, Michal Hladik
INTRODUCTION: Static renal scintigraphy is the gold standard for detection of inflammatory changes in the renal parenchyma in acute pyelonephritis. Our aim was to determine whether diffusion-weighted magnetic resonance imaging (DW-MRI) was comparable with static renal scintigraphy (DMSA-SRS) to demonstrate acute renal parenchymal lesions. OBJECTIVE: To compare 99m Tc-dimercaptosuccinic acid static renal scintigraphy (DMSA-SRS) with diffusion-weighted magnetic resonance imaging (DW-MRI) for detecting acute inflammatory changes in the renal parenchyma in children with febrile urinary tract infection...
March 13, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29577511/association-between-interleukin-8-receptor-gene-cxcr1-and-cxcr2-polymorphisms-and-urinary-tract-infection-evidence-from-4097-subjects
#8
Shi-Sheng Han, Yan Lu, Min Chen, Yan-Qiu Xu, Yi Wang
The aim of this study was to determine whether a correlation exists between interleukin-8 receptor polymorphisms and urinary tract infection (UTI) susceptibility. We systematically searched electronic databases including PubMed, Embase, China National Knowledge Infrastructure, and Web of Science up to November 5, 2017 to select appropriate studies that focused on C-X-C chemokine receptor type 1 and/or 2 (CXCR1, CXCR2) polymorphisms with susceptibility to UTI. Eight case-control studies including 2085 patients with UTI and 2012 controls were enrolled in this study...
March 25, 2018: Nephrology
https://www.readbyqxmd.com/read/29473304/non-enhanced-magnetic-resonance-imaging-versus-renal-scintigraphy-in-acute-pyelonephritis
#9
Jun Aoyagi, Takahiro Kanai, Jun Odaka, Takane Ito, Takashi Saito, Hiroyuki Betsui, Rieko Furukawa, Waka Nakata, Takanori Yamagata
The utility of non-enhanced magnetic resonance imaging (MRI) has not been examined extensively for diagnosing acute pyelonephritis (APN) in children. The aims of this study were to compare non-enhanced MRI with technetium-99 m dimercaptosuccinic acid (99m Tc-DMSA) renal scintigraphy in detecting APN. Six boys and one girl with temperature ≥38°C and positive urine culture received both non-enhanced MRI with whole body diffusion-weighted imaging (DWI) and 99m Tc-DMSA scintigraphy ≤7 days from the fever onset...
February 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29379541/vitamin-d-deficiency-is-associated-with-urinary-tract-infection-in-children
#10
Sherein Abdelhamid Shalaby, Nesrein Mosad Handoka, Rasha Emad Amin
Introduction: In humans, vitamin D has been shown to play a role in infectious diseases, but its association with acquisition and a complicated course of febrile urinary tract infections (UTIs) has not been investigated. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D3 ) levels and the risk of first time febrile UTI in children. Material and methods: This prospective case-control study included 50 children with first febrile UTI, with no risk factors for UTI, and 50 age- and sex-matched healthy siblings as controls...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29376597/-experience-of-157-vesikoscopic-operations-in-children
#11
A V Pirogov, V V Sizonov, M I Kogan
AIM: Recent advances in the field of minimally invasive surgical technologies in children and adolescents have led to the development of vesicoscopic (transvesical, pneumoscopic) access (VA). Current limitations in using VA emphasize the need for further studies investigating surgical options for the management of various pathological conditions of the bladder and ureterovesical junction, the features of surgical techniques and the course of the early postoperative period when used in pediatric urological practice...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29306986/d-dimer-as-a-marker-of-acute-pyelonephritis-in-infants-younger-than-24-months-with-urinary-tract-infection
#12
Jung Won Lee, Sun Mi Her, Ji Hong Kim, Keum Hwa Lee, Michael Eisenhut, Se Jin Park, Jae Il Shin
BACKGROUND: D-dimer, as well as other biomarkers related to coagulation, is significantly increased during severe bacterial infection and sepsis. The aim of this study was to evaluate the usefulness of serum D-dimer as a biological marker in diagnosing acute pyelonephritis (APN) and in predicting vesicoureteric reflux (VUR) in infants with urinary tract infection (UTI). METHODS: We retrospectively analyzed the data of 177 young infants (<2 years) with febrile UTI between 2005 and 2014, grouped as APN and lower UTI groups...
April 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29260318/the-utility-of-surveillance-biopsies-in-pediatric-kidney-transplantation
#13
Vikas R Dharnidharka, Neil Vyas, Joseph P Gaut, Leslie Walther, S Paul Hmiel
BACKGROUND: Surveillance biopsies (SBs) are performed in some pediatric kidney transplant programs, based on data obtained in earlier immunosuppressive eras that the treatment of subclinical acute rejection results in better graft survival. The benefit of SBs for patients on modern immunosuppression regimens is unclear. We have therefore evaluated the clinical utility of SBs in a population of children receiving a kidney transplant. METHODS: We have performed SBs at 3, 6 and 12 months post-transplantation as standard of care at our institution since 2013 in patients on a regimen of rabbit anti-thymocyte globulin, tacrolimus, mycophenolate and rapid steroid taper (RST; steroids maintained in some exceptions)...
May 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29201521/urinary-matrix-metalloproteinase-9-and-tissue-inhibitor-of-metalloproteinase-1-biomarkers-for-predicting-renal-scar-in-children-with-urinary-tract-infection
#14
Seyed Mohammad Abedi, Hamid Mohammadjafari, Alireza Rafiei, Sara Bazi, Pooneh Yazdani
Objective: Urinary tract infection occurs in 1.8-6.6% of children under 6 years old. The aim of this study was to assess the urinary concentrations of matrix metalloproteinase 9 (MMP9) and tissue inhibitor of metalloproteinase 1 (TIMP1), in children with acute pyelonephritis (APN) and the potential to develop renal scarring. Material and methods: Children who had experienced an episode of APN were divided into 2 groups. Group 1 included children with APN who exhibited scarring and group 2 included children with APN who had a normal99m Technetium dimercaptosuccinic acid scan...
December 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29142969/elucidation-of-renal-scars-in-children-with-vesicoureteral-reflux-using-contrast-enhanced-ultrasound-a-pilot-study
#15
David S Hains, Harris L Cohen, M Beth McCarville, Ellen E Ellison, Amy Huffman, Stacey Glass, Aslam H Qureshi, Keith R Pierce, Ashlyn L Cahill, Ashley Dixon, Noel Delos Santos
Introduction: Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is99m Tc-dimercaptosuccinic acid (DMSA) scintigraphy. DMSA has a number of limitations including radiation exposure, need for sedation, and radiotracer supply shortages. Contrast-enhanced ultrasound (CEUS) is a technique whereby biocompatible microspheres of inert gas are administered i.v. that reflect ultrasonography sound waves and do not involve radiation...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29138582/once-daily-intramuscular-amikacin-for-outpatient-treatment-of-lower-urinary-tract-infections-caused-by-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-in-children
#16
Meltem Polat, Soner Sertan Kara
Background: The rise in community-acquired urinary tract infections (UTIs) with extended-spectrum β-lactamase (ESBL)-producing Escherichia coli strains raises the question of how to treat these infections effectively in pediatric outpatients. Amikacin has shown promising in vitro activity against ESBL-producing urinary isolates of E. coli ; however, clinical data are limited. Objective: To investigate the clinical and microbiological outcomes of community-acquired lower UTIs caused by ESBL-producing E...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29134126/the-urinary-and-serum-levels-of-il-32-in-children-with-febrile-urinary-tract-infections
#17
Alireza Rafiei, Hamid Mohammadjafari, Ayat Ahifar, Abbas Alipour, Araz Mohammad Mirabi
Aim: We assessed the urinary and serum levels of IL-32 in pediatric patients with acute pyelonephritis (APN) with and without renal scarring. Results: We enrolled children aged 2 months to 16 years with APN. Dimercaptosuccinic acid scans and ultrasonography studies were ordered for all patients, and a voiding. A total of 86 children (aged 57 ± 39 months, 74 [86%] female) were enrolled in this study. Group 1 was composed of 19 (16 female) patients, group 2 of 38 (35 female) patients and group 3 of 29 (23 female) patients...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29100793/discrimination-of-culture-negative-pyelonephritis-in-children-with-suspected-febrile-urinary-tract-infection-and-negative-urine-culture-results
#18
Jun Ho Lee
BACKGROUND: We investigated whether the C-reactive protein (CRP) level, urine electrolytes, and urine sodium-potassium ratio (uNa/K) could be useful markers for discriminating children with culture negative pyelonephritis (CNP) from children with suspected febrile urinary tract infection (fUTI) and negative urine culture results. METHODS: We examined 264 children experiencing their first fUTI consecutively admitted to our hospital between January 2011 and October 2014...
October 25, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29090653/tuberculous-pyelonephritis-in-children-three-case-reports
#19
Nimisha Arora, Abhijeet Saha, Manpreet Kaur
Tuberculous pyelonephritis is rare in children; three case reports are presented. Case 1 was an 11-year-old girl with a previous history of pulmonary tuberculosis who presented with flank pain and fever for 10 days. An ultrasound suggested focal pyelonephritis, and a contrast-enhanced computed tomography (CECT) scan demonstrated acute focal pyelonephritis and a perinephric collection. Mycobacterium tuberculosis was cultured in the urine. She responded well to anti-tuberculous treatment (ATT). Case 2 was a 13-year-old boy who presented with fever, haematuria, burning micturition, proteinuria (3+) and cervical lymphadenopathy...
November 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29028278/functional-variants-in-intercellular-adhesion-molecule-1-and-toll-like-receptor-4-genes-are-more-frequent-in-children-with-febrile-urinary-tract-infection-with-renal-parenchymal-involvement
#20
Almontaser Hussein, Khaled Saad, Eman Askar, Asmaa M Zahran, Hekma Farghaly, Kotb Metwalley, Ahmad A Elderwy
AIM: We studied the functional polymorphisms of intercellular adhesion molecule-1 (ICAM-1) and toll-like receptor-4 (TLR-4) genes and risk of acute pyelonephritis (APN) in children attending Assiut University Children's Hospitals, Egypt, from 2011 to 2015. METHODS: Urinary tract infections (UTIs) were diagnosed in 380 children: 98 had APN and 282 had lower UTIs. Four single-nucleotide polymorphisms in ICAM-1 and TLR-4 genes were genotyped in all subjects: ICAM-1 rs1799969 Gly241Arg, ICAM-1 rs5498 Glu469Lys, TLR-4 rs4896791 Thr399Ile and TLR-4 rs4896790 Asp299Gly...
February 2018: Acta Paediatrica
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