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endodontic regeneration, revascularization

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https://www.readbyqxmd.com/read/28765825/comparison-of-the-effect-of-prp-prf-and-induced-bleeding-in-the-revascularization-of-teeth-with-necrotic-pulp-and-open-apex-a-triple-blind-randomized-clinical-trial
#1
Vasundara Yayathi Shivashankar, Dexton Antony Johns, Ramesh Kumar Maroli, Mahalaxmi Sekar, Rathinavel Chandrasekaran, Shanmugavel Karthikeyan, Senthil Kumar Renganathan
INTRODUCTION: Treatment of a tooth with necrotic pulp and open apex is a special challenge to the clinicians. Apexification with calcium hydroxide and MTA barrier technique fails to induce continued root maturation which makes the tooth susceptible to root fracture. Hence, an ideal outcome for such a tooth should be regeneration of pulp like tissue into the root canal capable of continuing normal root maturation. AIM: This study aims to compare the effect of Platelet Rich Fibrin (PRF), induced bleeding technique and Platelet Rich Plasma (PRP) in the revascularization of tooth with necrotic pulp and open apex...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28415948/use-of-platelet-rich-plasma-for-regeneration-in-non-vital-immature-permanent-teeth-clinical-and-cone-beam-computed-tomography-evaluation
#2
Adel Alagl, Sumit Bedi, Khalid Hassan, Jehan AlHumaid
Objective This study was performed to assess the clinical and radiological outcomes of a revascularization procedure in immature teeth with apical periodontitis using platelet-rich plasma (PRP). The PRP protocol and conventional revascularization protocol, which used a blood clot as the scaffold, were compared. Methods Thirty non-vital immature permanent teeth were randomly categorized into two groups. After disinfecting the root canal space with triple antibiotic paste (1:1:1 ciprofloxacin, metronidazole, and cefaclor), a tissue scaffold was created using either PRP or a blood clot (control) and covered with white mineral trioxide aggregate...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28372291/current-challenges-in-human-tooth-revitalization
#3
REVIEW
Maxime Ducret, Hugo Fabre, Alexis Celle, Frédéric Mallein-Gerin, Emeline Perrier-Groult, Brigitte Alliot-Licht, Jean-Christophe Farges
Tooth vitality and health are related to the presence of a living connective tissue, the dental pulp (DP), in the center of the dental organ. The DP contains the tooth immune defence system that is activated against invading oral cariogenic bacteria during the caries process and the tissue repair/regeneration machinery involved following microorganisms' eradication. However, penetration of oral bacteria into the DP often leads to complete tissue destruction and colonization of the endodontic space by microorganisms...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28342218/histological-assessment-of-regenerative-endodontic-treatment-in-animal-studies-with-different-scaffolds-a-systematic-review
#4
REVIEW
Milad Altaii, Lindsay Richards, Giampiero Rossi-Fedele
BACKGROUND/AIM: The concept of regenerative endodontic procedures remains controversial. The aim of this study was to evaluate the histology of the tissues formed in immature animal teeth with necrotic and infected pulps after attempted endodontic regeneration procedures using different scaffolds. DESIGN: A systematic electronic literature search was performed in PubMed, Web of Science, Scopus, EMBASE, DOSS, and Cochrane Library databases. The terms used were a combination of the following: "immature permanent necrotic tooth or teeth" or "open apex or apices" and "regeneration or revitalization or revascularization" and "histology...
March 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28131412/second-generation-platelet-concentrate-platelet-rich-fibrin-as-a-scaffold-in-regenerative-endodontics-a-case-series
#5
Hengameh Bakhtiar, Shahram Esmaeili, Setareh Fakhr Tabatabayi, Mohammad Reza Ellini, Mohammad Hossein Nekoofar, Paul M H Dummer
INTRODUCTION: The purpose of this case series was to report the clinical and radiographic results of a pulp regenerative procedure using platelet-rich fibrin (PRF), a second-generation platelet concentrate, in immature teeth with necrotic pulps. METHODS: Root canal revascularization using PRF was performed on 4 immature teeth with necrotic pulps. After access cavity preparation, the root canals were irrigated with low concentration sodium hypochlorite solution (1...
March 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/27694153/effect-of-residual-bacteria-on-the-outcome-of-pulp-regeneration-in-vivo
#6
P Verma, A Nosrat, J R Kim, J B Price, P Wang, E Bair, H H Xu, A F Fouad
It is not known to what extent residual infection may interfere with the success of pulp regeneration procedures. The aim of this study was to determine, radiographically and histologically, the effect of residual bacteria on the outcome of pulp regeneration mediated by a tissue-engineered construct as compared with traditional revascularization. Periapical lesions were induced in 24 canine teeth of 6 ferrets. After disinfection with 1.25% NaOCl and triple antibiotic paste, ferret dental pulp stem cells, encapsulated in a hydrogel scaffold, were injected into half the experimental teeth...
January 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/27623497/influence-of-age-and-apical-diameter-on-the-success-of-endodontic-regeneration-procedures
#7
Bishoy Safwat Estefan, Kariem Mostafa El Batouty, Mohamed Mokhtar Nagy, Anibal Diogenes
INTRODUCTION: Treatment of immature permanent teeth with necrotic pulp and apical pathosis constitutes a challenge for endodontists. The present study was done to evaluate the effect of age and apical diameter on the regenerative potential of young permanent immature teeth with necrotic pulps. METHODS: Immature necrotic permanent maxillary incisors (n = 40) of patients 9-18 years old were divided into 2 groups according to the treatment protocol: group Y (younger age group), 9-13 years and group O (older age group), 14-18 years...
November 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27200277/biocompatibility-of-two-experimental-scaffolds-for-regenerative-endodontics
#8
Dephne Jack Xin Leong, Frank C Setzer, Martin Trope, Bekir Karabucak
OBJECTIVES: The biocompatibility of two experimental scaffolds for potential use in revascularization or pulp regeneration was evaluated. MATERIALS AND METHODS: One resilient lyophilized collagen scaffold (COLL), releasing metronidazole and clindamycin, was compared to an experimental injectable poly(lactic-co-glycolic) acid scaffold (PLGA), releasing clindamycin. Human dental pulp stem cells (hDPSCs) were seeded at densities of 1.0 × 10(4), 2.5 × 10(4), and 5...
May 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27014076/pulp-regeneration-current-approaches-and-future-challenges
#9
REVIEW
Jingwen Yang, Guohua Yuan, Zhi Chen
Regenerative endodontics aims to replace inflamed/necrotic pulp tissues with regenerated pulp-like tissues to revitalize teeth and improve life quality. Pulp revascularization case reports, which showed successful clinical and radiographic outcomes, indicated the possible clinical application of pulp regeneration via cell homing strategy. From a clinical point of view, functional pulp-like tissues should be regenerated with the characterization of vascularization, re-innervation, and dentin deposition with a regulated rate similar to that of normal pulp...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/26699211/regenerative-endodontics-creating-new-horizons
#10
REVIEW
Harnoor Dhillon, Mamta Kaushik, Roshni Sharma
Trauma to the dental pulp, physical or microbiologic, can lead to inflammation of the pulp followed by necrosis. The current treatment modality for such cases is non-surgical root canal treatment. The damaged tissue is extirpated and the root canal system prepared. It is then obturated with an inert material such a gutta percha. In spite of advances in techniques and materials, 10%-15% of the cases may end in failure of treatment. Regenerative endodontics combines principles of endodontics, cell biology, and tissue engineering to provide an ideal treatment for inflamed and necrotic pulp...
May 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/26631301/autologous-platelet-concentrates-for-pulp-and-dentin-regeneration-a-literature-review-of-animal-studies
#11
REVIEW
Massimo Del Fabbro, Alessandra Lolato, Cristina Bucchi, Silvio Taschieri, Roberto L Weinstein
INTRODUCTION: The purpose of this study was to evaluate the effectiveness of autologous platelet concentrates (APCs) in promoting pulp and dentin regeneration in animal models. METHODS: An electronic search was performed on MEDLINE, Embase, Scopus, SciELO, LILACS, and CENTRAL. Animal studies using APC as a root filling material after pulpectomy in mature or immature teeth were included. Articles underwent risk of bias assessment. Histologic evaluation of intracanal neoformed tissue was the primary outcome; root development, root wall thickening, apical closure, and periapical healing in apical periodontitis were the secondary outcomes...
February 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/26506811/current-applications-and-future-prospects-of-stem-cells-in-dentistry
#12
Sharmila Surendran, Gautham Sivamurthy
Stem cells are defined as clonogenic, unspecialized cells capable of both selt-renewal and multi-lineage differentiation, contributing to regenerating specific tissues. For years, restorative treatments have exploited the lifelong regenerative potential of dental pulp stem cells to give rise to tertiary dentine, which is therapeutically employed for direct and indirect pulp capping. Current applications of stem cells in endodontic research have revealed their potential to continue root development in necrotic immature teeth and transplanted/replanted teeth...
July 2015: Dental Update
https://www.readbyqxmd.com/read/26409809/pulp-and-periodontal-regeneration-of-an-avulsed-permanent-mature-incisor-using-platelet-rich-plasma-after-delayed-replantation-a-12-month-clinical-case-study
#13
Harini Priya M, Pavan B Tambakad, Jaya Naidu
Numerous publications have reported revascularization of necrotic immature permanent teeth, but the regenerative potential of pulp in mature teeth has rarely been considered. Platelet-rich plasma (PRP) meets many requirements of a scaffold for regenerative endodontics. To the best of our knowledge, no clinical study has evaluated PRP for endodontic regeneration in a mature avulsed tooth. The present case evaluated PRP for pulpal regeneration in an avulsed mature incisor (>8 hours extraoral dry time) of an 11-year-old boy after delayed replantation...
January 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/26310721/pulp-dentin-regeneration-current-state-and-future-prospects
#14
REVIEW
Y Cao, M Song, E Kim, W Shon, N Chugal, G Bogen, L Lin, R H Kim, N-H Park, M K Kang
The goal of regenerative endodontics is to reinstate normal pulp function in necrotic and infected teeth that would result in reestablishment of protective functions, including innate pulp immunity, pulp repair through mineralization, and pulp sensibility. In the unique microenvironment of the dental pulp, the triad of tissue engineering would require infection control, biomaterials, and stem cells. Although revascularization is successful in resolving apical periodontitis, multiple studies suggest that it alone does not support pulp-dentin regeneration...
November 2015: Journal of Dental Research
https://www.readbyqxmd.com/read/25797716/potential-dental-pulp-revascularization-and-odonto-osteogenic-capacity-of-a-novel-transplant-combined-with-dental-pulp-stem-cells-and-platelet-rich-fibrin
#15
Yong-Jin Chen, Yin-Hua Zhao, Ya-Juan Zhao, Nan-Xia Liu, Xin Lv, Qiang Li, Fa-Ming Chen, Min Zhang
Our aim is to investigate the cytobiological effects of autologous platelet-rich fibrin (PRF) on dental pulp stem cells (DPSCs) and to explore the ectopic and orthotopic possibilities of dental pulp revascularization and pulp-dentin complex regeneration along the root canal cavities of the tooth by using a novel tissue-engineered transplant composed of cell-sheet fragments of DPSCs and PRF granules. Canine DPSCs were isolated and characterized by assaying their colony-forming ability and by determining their cell surface markers and osteogenic/adipogenic differentiation potential...
August 2015: Cell and Tissue Research
https://www.readbyqxmd.com/read/25571677/tissue-engineering-in-endodontics-root-canal-revascularization
#16
REVIEW
Palit Madhu Chanda, K Sundeep Hegde, Sham S Bhat, Sharan S Sargod, Somasundar Mantha, Sayan Chattopadhyay
Root canal revascularization attempts to make necrotic tooth alive by the use of certain simple clinical protocols. Earlier apexification was the treatment of choice for treating and preserving immature permanent teeth that have lost pulp vitality. This procedure promoted the formation of apical barrier to seal the root canal of immature teeth and nonvital filling materials contained within root canal space. However with the success of root canal revascularization to regenerate the pulp dentin complex of necrotic immature tooth has made us to rethink if apexification is at the beginning of its end...
2014: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/25530890/regenerative-endodontic-treatment-of-an-infected-immature-dens-invaginatus-with-the-aid-of-cone-beam-computed-tomography
#17
Işıl Kaya-Büyükbayram, Şerife Özalp, Emre Aytugar, Seda Aydemir
Dens invaginatus is a developmental anomaly that results in an enamel-lined cavity intruding into the crown or root before the mineralization phase. This report presents regenerative endodontic treatment of a necrotic immature tooth with Oehler's type III dens invaginatus of a nine-year-old female patient. A diagnosis of dens invaginatus (Oehler's type III) and a large periapical lesion was established with the aid of cone-beam computed tomography (CBCT). In the presented case contrary to the classic revascularization protocol, mechanical instrumentation was performed which apparently did not interfere with the regeneration process...
2014: Case Reports in Dentistry
https://www.readbyqxmd.com/read/25503339/apexification-apexogenesis-and-regenerative-endodontic-procedures-a-review-of-the-literature
#18
REVIEW
S Corbella, G Ferrara, A El Kabbaney, S Taschieri
AIM: Aim of this paper was to present the therapeutical approaches to the management of the immature apex and discuss the evolution of materials and techniques. METHODS: A Medline search was performed limited to human studies published. The keywords searched were apexogenesis, apexification, pulp regeneration, revascularization. RESULTS: Apexogenesis and apexification techniques using Calcium hydroxide or MTA give a high succes rate. Recent regeneration procedures may be helpful for apexification in non vital elements...
November 2014: Minerva Stomatologica
https://www.readbyqxmd.com/read/24992862/healing-of-large-periapical-lesions-following-delivery-of-dental-stem-cells-with-an-injectable-scaffold-new-method-and-three-case-reports
#19
Vahab Shiehzadeh, Farhad Aghmasheh, Farideh Shiehzadeh, Mohammad Joulae, Emad Kosarieh, Farid Shiehzadeh
Regenerative endodontics is the creation and delivery of tissues to replace diseased, missing, and traumatized pulp. A call for a paradigm shift and new protocol for the clinical management of these cases has been brought to attention. These regenerative endodontic techniques will possibly involve some combination of disinfection or debridement of infected root canal systems with apical enlargement to permit revascularization and use of stem cells, scaffolds, and growth factors. Mesenchymal stem cells (MSCs) have been isolated from the pulp tissue of permanent teeth (dental pulp stem cells (DPSCs)) and deciduous teeth (stem cells from human exfoliated deciduous teeth)...
March 2014: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/24879576/missing-concepts-in-de-novo-pulp-regeneration
#20
REVIEW
G T-J Huang, F Garcia-Godoy
Regenerative endodontics has gained much attention in the past decade because it offers an alternative approach in treating endodontically involved teeth. Instead of filling the canal space with artificial materials, it attempts to fill the canal with vital tissues. The objective of regeneration is to regain the tissue and restore its function to the original state. In terms of pulp regeneration, a clinical protocol that intends to reestablish pulp/dentin tissues in the canal space has been developed--termed revitalization or revascularization...
August 2014: Journal of Dental Research
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