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https://www.readbyqxmd.com/read/29678731/age-related-rise-in-lactate-and-its-correlation-with-lactate-dehydrogenase-ldh-status-in-post-mitochondrial-fractions-isolated-from-different-regions-of-brain-in-mice
#1
Siddhartha Datta, Nilkanta Chakrabarti
Rise in brain lactate is the hallmark of ageing. Separate studies report that ageing is associated with elevation of lactate level and alterations of lactate dehydrogenase (LDH)-A/B mRNA-expression-ratio in cerebral cortex and hippocampus. However, age related lactate rise in brain and its association with LDH status and their brain regional variations are still elusive. In the present study, level of lactate, LDH (A and B) activity and LDH-A expression were evaluated in post-mitochondrial fraction of tissues isolated from four different brain regions (cerebral cortex, hippocampus, substantia nigra and cerebellum) of young and aged mice...
April 17, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29678619/effect-of-goal-directed-fluid-therapy-on-early-cognitive-function-in-elderly-patients-with-spinal-stenosis
#2
Na Zhang, Min Liang, Dan-Dan Zhang, Yi-Rong Xiao, Yan-Zhen Li, You-Guang Gao, Hong-da Cai, Xian-Zhong Lin, Cai-Zhu Lin, Kai Zeng, Xiao-Dan Wu
PURPOSE: To explore effect of goal-directed fluid therapy (GDFT) on early cognitive function in elderly patients with spinal stenosis. METHODS: 83 elderly patients with spinal stenosis were randomly classified into two groups: control group (n = 40) and GDFT group (n = 43). The Montreal Cognitive Assessment (MoCA) score, IL-6 and S100β levels, hemodynamic parameters, cerebral oxygen saturation (rSO2 ), arterial lactic acid values, output of surgery, operation time and cases of hypotension, intraoperative complications within 7 days were recorded for all patients...
April 17, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29666925/-which-patients-benefit-from-transport-with-ongoing-cardiopulmonary-resuscitation-retrospective-analysis-of-70-patients-with-refractory-preclinical-cardiac-arrest
#3
C Adler, C Paul, J Hinkelbein, G Michels, R Pfister, A Krings, A Lechleuthner, R Stangl
BACKGROUND: Mortality in patients with out-of-hospital cardiac arrest (OHCA) remains very high despite advances in resuscitation algorithms. Most of these patients die at the scene and do not reach hospital. It is currently the subject of discussion whether transport to hospital with ongoing cardiopulmonary resuscitation (CPR) improves survival and neurological outcome in patients with OHCA. OBJECTIVE: The aim of this study was to identify predictors of survival and good neurological outcome in patients after OHCA who were transported to hospital with ongoing CPR...
April 17, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29655502/effect-of-regional-cerebral-oximetry-to-estimate-neurologic-prognostic-outcomes-in-patients-administered-targeted-temperature-management
#4
Aykut Sarıtaş, Burcu Acar Çinleti, Çiler Zincircioğlu, Uğur Uzun, Işıl Köse, Nimet Şenoğlu
PURPOSE: The aim of our study is to research the role and efficacy of cerebral oximetry in predicting neurologic prognosis when applied during TTM to patients experiencing coma after CA. METHODS: This study was performed on surviving adult comatose patients after CA treated with TTM. The average scores of rSO2 was measured at 6h intervals for the first 2days and once a day for the following 3days with a NIRS device during TTM. The CPC scale was used to define the neurologic outcomes of patients...
April 9, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29649792/comparison-of-different-compression-to-ventilation-ratios-2-1-3-1-and-4-1-during-cardiopulmonary-resuscitation-in-a-porcine-model-of-neonatal-asphyxia
#5
Matteo P Pasquin, Po-Yin Cheung, Sparsh Patel, Min Lu, Tze-Fun Lee, Michael Wagner, Megan O'Reilly, Georg M Schmölzer
BACKGROUND: High-quality chest compression is essential during neonatal cardiopulmonary resuscitation (CPR). However, the optimal compression to ventilation ratio (C:V) that should be used during neonatal CPR to optimize coronary and cerebral perfusion while providing adequate ventilation remains unknown. OBJECTIVE: We hypothesized that different C:V ratios (e.g., 2: 1 or 4: 1) will reduce the time to return of spontaneous circulation (ROSC) in severely asphyxiated piglets...
April 12, 2018: Neonatology
https://www.readbyqxmd.com/read/29621117/cerebral-multimodal-monitoring-in-sepsis-an-experimental-study
#6
Pedro Kurtz, Joana C d'Avila, Darwin Prado, Caroline Madeira, Charles Vargas-Lopes, Rogerio Panizzutti, Luciano Cesar Pontes Azevedo, Fernando A Bozza
Acute brain dysfunction is a complication of sepsis and its pathophysiology remains poorly understood. We studied the brain metabolism in a resuscitated animal model of sepsis. Twelve anesthetized, mechanically ventilated and invasively monitored pigs were allocated to a sham procedure (N = 5) or sepsis (N = 7). Sepsis was induced through fecal inoculation in the peritoneum. Fluid resuscitation was maintained during the entire study period. Animals were observed until spontaneous death or for a maximum of 24 hours...
April 4, 2018: Shock
https://www.readbyqxmd.com/read/29605768/perinatal-exposure-to-energy-drink-induces-oxidative-damage-in-the-liver-kidney-and-brain-and-behavioral-alterations-in-mice-offspring
#7
Gadh I Al-Basher, Hanan Aljabal, Rafa S Almeer, Ahmed A Allam, Ayman M Mahmoud
The worldwide consumption of energy drinks (EDs) has increased in recent years. EDs have several side effects and can be linked to liver injury, kidney damage and risk-seeking behavior. The impact of perinatal consumption of EDs on the newborns has not been previously investigated. In this study, we evaluated the effects of perinatal exposure to a caffeinated ED on the liver, kidney, brain, locomotor activity and anxiety in mice newborns. Pregnant mice received 2.5 or 5 ml ED by oral gavage from the first day of pregnancy until day 15 after birth...
March 29, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29590367/selective-visceral-perfusion-improves-renal-flow-and-hepatic-function-in-neonatal-aortic-arch-repair
#8
Joaquín Fernández-Doblas, Christian Ortega-Loubon, Joaquín Pérez-Andreu, Marcos Linés, Manuel Fernández-Molina, Raúl F Abella
OBJECTIVES: The aortic arch repair in the neonatal period is a complex procedure with significant morbidity. We define a useful double-perfusion technique and its effect on the function of abdominal organs in the postoperative course. METHODS: Nine patients with double perfusion (Group 1) were compared with 14 patients with antegrade cerebral perfusion (Group 2). The objective was to discern the incidence of postoperative acute kidney injury and impaired hepatic function, as well as tissue perfusion and myocardial function parameters...
March 26, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29577222/-establishment-of-comprehensive-prediction-model-of-acute-gastrointestinal-injury-classification-of-critically-ill-patients
#9
Yan Wang, Jianrong Wang, Weiwei Liu, Guangliang Zhang
OBJECTIVE: To develop the comprehensive prediction model of acute gastrointestinal injury (AGI) grades of critically ill patients. METHODS: From April 2015 to November 2015, the binary channel gastrointestinal sounds (GIS) monitor system which has been developed and verified by the research group was used to gather and analyze the GIS of 60 consecutive critically ill patients who were admitted in Critical Care Medicine of Chinese PLA General Hospital. Also, the AGI grades (Grande I(-IIII(, the higher the level, the heavier the gastrointestinal dysfunction) were evaluated...
March 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29566695/cerebrospinal-fluid-plasmodium-falciparum-histidine-rich-protein-2-in-pediatric-cerebral-malaria
#10
Kiran T Thakur, Jimmy Vareta, Kathryn A Carson, Samuel Kampondeni, Michael J Potchen, Gretchen L Birbeck, Ian MacCormick, Terrie Taylor, David J Sullivan, Karl B Seydel
BACKGROUND: Cerebral malaria (CM) causes a rapidly developing coma, and remains a major contributor to morbidity and mortality in malaria-endemic regions. This study sought to determine the relationship between cerebrospinal fluid (CSF) Plasmodium falciparum histidine rich protein-2 (PfHRP-2) and clinical, laboratory and radiographic features in a cohort of children with retinopathy-positive CM. METHODS: Patients included in the study were admitted (2009-2013) to the Pediatric Research Ward (Queen Elizabeth Central Hospital, Blantyre, Malawi) meeting World Health Organization criteria for CM with findings of malarial retinopathy...
March 23, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29560599/cerebral-near-infrared-spectroscopy-in-adult-patients-undergoing-veno-arterial-extracorporeal-membrane-oxygenation
#11
Selene Pozzebon, Aaron Blandino Ortiz, Federico Franchi, Stefano Cristallini, Mirko Belliato, Olivier Lheureux, Alexandre Brasseur, Jean-Louis Vincent, Sabino Scolletta, Jacques Creteur, Fabio Silvio Taccone
BACKGROUND: Acute cerebral complications (ACC) of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are associated with poor long-term neurologic outcome. We described the role of rSO2 monitoring in detecting ACC and desaturations and their relationship with poor outcome when employing VA-ECMO. METHODS: Retrospective analysis of patients monitored by cerebral frontal near-infrared spectroscopy (NIRS) (CAS Medical Systems Inc., Branford, CT, USA) during VA-ECMO (November 2008-December 2015)...
March 20, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29559675/microbiome-metabolome-signatures-in-mice-genetically-prone-to-develop-dementia-fed-a-normal-or-fatty-diet
#12
Elena Sanguinetti, Maria Carmen Collado, Vannina G Marrachelli, Daniel Monleon, Marta Selma-Royo, Mercedes M Pardo-Tendero, Silvia Burchielli, Patricia Iozzo
Cognitive decline, obesity and gut dysfunction or microbial dysbiosis occur in association. Our aim was to identify gut microbiota-metabolomics signatures preceding dementia in genetically prone (3xtg) mice, with and without superimposed high-fat diet. We examined the composition and diversity of their gut microbiota, and serum and faecal metabolites. 3xtg mice showed brain hypometabolism typical of pre-demented stage, and lacked the physiological bacterial diversity between caecum and colon seen in controls...
March 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29554649/pioglitazone-confers-neuroprotection-against-ischemia-induced-pyroptosis-due-to-its-inhibitory-effects-on-hmgb-1-rage-and-rac1-ros-pathway-by-activating-ppar-%C3%A9
#13
Pingping Xia, Yundan Pan, Fan Zhang, Na Wang, E Wang, Qulian Guo, Zhi Ye
BACKGROUND/AIMS: Recent researches highlighted the protective potential of pioglitazone, a PPAR-γ agonist, in the progression of cerebral ischemia-reperfusion injury. However, there has been no study on the application of pioglitazone in treating ischemic stroke through mechanisms involving pyroptosis. METHODS: The cerebral injury was established by middle cerebral artery occlusion (MCAO). in vitro ischemia in primary cultured astrocytes was induced by the oxygen-glucose deprivation (OGD)...
March 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29553298/neuronal-glucose-metabolism-is-impaired-while-astrocytic-tca-cycling-is-unaffected-at-symptomatic-stages-in-the-hsod1-g93a-mouse-model-of-amyotrophic-lateral-sclerosis
#14
Tesfaye W Tefera, Karin Borges
Although alterations in energy metabolism are known in ALS, the specific mechanisms leading to energy deficit are not understood. We measured metabolite levels derived from injected [1-13 C]glucose and [1,2-13 C]acetate (i.p.) in cerebral cortex and spinal cord extracts of wild type and hSOD1G93A mice at onset and mid disease stages using high-pressure liquid chromatography,1 H and13 C nuclear magnetic resonance spectroscopy. Levels of spinal and cortical CNS total lactate, [3-13 C]lactate, total alanine and [3-13 C]alanine, but not cortical glucose and [1-13 C]glucose, were reduced mostly at mid stage indicating impaired glycolysis...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29551689/acidosis-mediates-recurrent-hypoglycemia-induced-increase-in-ischemic-brain-injury-in-treated-diabetic-rats
#15
Ashish K Rehni, Vibha Shukla, Miguel A Perez-Pinzon, Kunjan R Dave
OBJECTIVES: Cerebral ischemia is a serious possible manifestation of diabetic vascular disease. Recurrent hypoglycemia (RH) enhances ischemic brain injury in insulin-treated diabetic (ITD) rats. In the present study, we determined the role of ischemic acidosis in enhanced ischemic brain damage in RH-exposed ITD rats. METHODS: Diabetic rats were treated with insulin and mild/moderate RH was induced for 5 days. Three sets of experiments were performed. The first set evaluated the effects of RH exposure on global cerebral ischemia-induced acidosis in ITD rats...
March 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29536741/the-relationship-between-intracranial-pressure-and-lactate-pyruvate-ratio-in-patients-with-subarachnoid-haemorrhage
#16
T Cesak, J Adamkov, J Habalova, P Poczos, M Kanta, M Bartos, T Hosszu
AIM: The aim of this study was to analyse the relationship between intracranial pressure (intracranial pressure monitoring) and lactate pyruvate ratio (cerebral microdialysis) in patients with ruptured intracranial aneurysms. METHODS: In a group of fifteen patients, intracranial pressure and lactate/pyruvate ratios were measured and logged in hourly intervals. The relationship between these two variables was subsequently analysed in two ways. 1) Intracranial hypertension (ICP > 20 mmHg) in the presence of energy deprivation (L/P ratio > 30) was noted...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29521586/upregulation-of-mir-216a-exerts-neuroprotective-effects-against-ischemic-injury-through-negatively-regulating-jak2-stat3-involved-apoptosis-and-inflammatory-pathways
#17
Yu Shuang Tian, Di Zhong, Qing Qing Liu, Xiu Li Zhao, Hong Xue Sun, Jing Jin, Hai Ning Wang, Guo Zhong Li
OBJECTIVE Ischemic stroke remains a significant cause of death and disability in industrialized nations. Janus tyrosine kinase (JAK) and signal transducer and activator of transcription (STAT) of the JAK2/STAT3 pathway play important roles in the downstream signal pathway regulation of ischemic stroke-related inflammatory neuronal damage. Recently, microRNAs (miRNAs) have emerged as major regulators in cerebral ischemic injury; therefore, the authors aimed to investigate the underlying molecular mechanism between miRNAs and ischemic stroke, which may provide potential therapeutic targets for ischemic stroke...
March 9, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29510389/inhibition-of-mirna-125b-decreases-cerebral-ischemia-reperfusion-injury-by-targeting-ck2%C3%AE-nadph-oxidase-signaling
#18
Yong Liang, Jing Xu, Yu Wang, Jia-Yu Tang, Song-Lin Yang, Hong-Guang Xiang, Shi-Xing Wu, Xiao-Juan Li
BACKGROUND/AIMS: Cerebral ischemia-reperfusion (I/R) injury involves multiple independently fatal terminal pathways. CK2α/NADPH oxidase is an important signaling pathway associated with ischemia-reperfusion injury, and miR-125b can regulate oxidative stress-related injury. In this study, we investigated whether the effect of miR-125b in rat brain I/R injury occurs through its modulation of the CK2α/NADPH oxidase pathway. METHODS: Rats were subjected to 2 h of cerebral ischemia followed by 24 h of reperfusion to establish an I/R injury model...
February 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29508265/cerebral-metabolic-changes-related-to-oxidative-metabolism-in-a-model-of-bacterial-meningitis-induced-by-lipopolysaccharide
#19
M Munk, F R Poulsen, L Larsen, C H Nordström, T H Nielsen
BACKGROUND: Cerebral mitochondrial dysfunction is prominent in the pathophysiology of severe bacterial meningitis. In the present study, we hypothesize that the metabolic changes seen after intracisternal lipopolysaccharide (LPS) injection in a piglet model of meningitis is compatible with mitochondrial dysfunction and resembles the metabolic patterns seen in patients with bacterial meningitis. METHODS: Eight pigs received LPS injection in cisterna magna, and four pigs received NaCl in cisterna magna as a control...
March 5, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/29506576/effects-of-isoflurane-sevoflurane-propofol-and-alfaxalone-on-brain-metabolism-in-dogs-assessed-by-proton-magnetic-resonance-spectroscopy-1-h-mrs
#20
Franz Josef Söbbeler, Inés Carrera, Kirby Pasloske, Millagahamada Gedara Ranasinghe, Patrick Kircher, Sabine Beate Rita Kästner
BACKGROUND: The purpose of this study was to determine the effects of isoflurane, sevoflurane, propofol and alfaxalone on the canine brain metabolite bioprofile, measured with single voxel short echo time proton magnetic resonance spectroscopy at 3 Tesla. Ten adult healthy Beagle dogs were assigned to receive isoflurane, sevoflurane, propofol and alfaxalone at 3 different dose rates each in a randomized cross-over study design. Doses for isoflurane, sevoflurane, propofol and alfaxalone were FE 'Iso 1...
March 5, 2018: BMC Veterinary Research
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