keyword
MENU ▼
Read by QxMD icon Read
search

lactate cerebral

keyword
https://www.readbyqxmd.com/read/29436658/effect-of-garlic-on-rats-with-chronic-intermittent-hypoxia-combined-with-diabetes-mellitus
#1
Yinglan Peng, Ke Hu
The present study investigated the effect of garlic (G) on serum, liver, renal and cerebral parameters of rats with chronic intermittent hypoxia (CIH) combined with diabetes mellitus (DM). A total of 32 rats were divided into eight groups, with 4 rats/group. A total of three models were established, including CIH, DM and CIH‑DM, and an additional healthy control (C) group. Rats in C‑G, CIH‑G, DM‑G and CIH‑DM‑G groups were injected with a G extract daily. Serum, liver, renal and cerebral parameters were detected...
February 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436577/rp105-protects-pc12-cells-from-oxygen%C3%A2-glucose-deprivation-reoxygenation-injury-via-activation-of-the-pi3k-akt-signaling-pathway
#2
Yanpeng Sun, Lu Liu, Jiang Yuan, Qiang Sun, Na Wang, Yunfu Wang
Radioprotective 105 kDa protein (RP105) has been reported to produce favorable outcomes in various cardiovascular disorders via a toll‑like receptor 4‑dependent or ‑independent manner. However, whether RP105 exerts neuroprotective effects against oxygen‑glucose deprivation (OGD)/reoxygenation (OGD/R) injury remains to be elucidated. In the present study, the PC12 neuronal cell line was exposed to 4 h of OGD followed by 24 h of reoxygenation. Adenoviral vectors encoding RP105 were utilized to upregulate the level of RP105 in PC12 cells prior to OGD/R induction...
February 12, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29421768/developmental-neurotoxicity-in-the-progeny-after-maternal-gavage-with-chlorpyrifos
#3
Bérengère Laporte, Jérôme Gay-Quéheillard, Véronique Bach, Anne-Sophie Villégier
Today, developmental intellectual disorders affect one out of six children in industrialised countries. Intensively used in agriculture, the neurotoxicant pesticide chlorpyrifos (CPF) is known for its environmental persistence and bioaccumulation. Its role has not yet been established in the aetiology of intellectual impairments. Here we assessed whether maternal ingestion of low CPF dose in rats could impair the cerebral function of their progeny. Rat dams received daily CPF exposures (1 mg/kg, per os) during gestation and lactation...
January 25, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29408682/neurochemical-changes-in-unilateral-cerebralhemisphere-during-the-subacute-stage-of-focal-cerebral-ischemia-reperfusion-in-rats-an-ex-vivo-1h-magnetic-resonance-spectroscopy-study
#4
Qun Huang, Chen Li, Nengzhi Xia, Liangcai Zhao, Dan Wang, Yunjun Yang, Hongchang Gao
Understanding the subacute may shed light on the mechanism of cerebral ischemia. The present study aimed to explore metabolic features underlying subacute stage of ischemia-reperfusion injury and developing effective treatments. Rats were divided into three groups: the permanent middle cerebral artery occlusion (pMCAO), transient cerebral focal ischemia (tMCAO) and sham group. Evaluation of animal models was performed by the neurological deficit, MR images and pathological morphological abnormality. To elucidate metabolic changes, we conducted a comparative analysis of metabolic composition of unilateral brain tissue using 1H nuclear magnetic resonance spectroscopy...
January 31, 2018: Brain Research
https://www.readbyqxmd.com/read/29399057/microrna-29b-alleviates-oxygen-and-glucose-deprivation-reperfusion-induced-injury-via-inhibition-of-the-p53-dependent-apoptosis-pathway-in-n2a-neuroblastoma-cells
#5
Lei Cao, Yu Zhang, Shuai Zhang, Tian-Peng Jiang, Li Chen, Jing Liu, Shi Zhou
Cerebral ischemic injury causes severe brain damage and remains one of the leading causes of morbidity and mortality worldwide. Members of the microRNA-29 (miR-29) family are involved in regulating the process of ischemia and may be developed as biomarkers to diagnose and treat cerebral ischemia. The role of miR-29b in cerebral ischemia injury remains poorly understood. The purpose of the present study was to investigate whether miR-29b overexpression suppressed cerebral ischemic injury and to explore its underlying mechanism of action...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29375691/synergistic-neuroprotective-effects-of-geniposide-and-ursodeoxycholic-acid-in-hypoxia-reoxygenation-injury-in-sh-sy5y-cells
#6
Fafeng Cheng, Chongyang Ma, Liangming Sun, Xiaoyu Zhang, Changming Zhai, Changxiang Li, Shuang Zhang, Beida Ren, Shuling Liu, Songnan Liu, Xiangjun Yin, Xueqian Wang, Qingguo Wang
Endoplasmic reticulum stress (ERS) and autophagy activation play important roles in the process of cerebral ischemia/reperfusion (I/R) injury. The synergistic protective effects of Geniposide and ursodeoxycholic acid against cellular apoptosis caused by oxygen-glucose deprivation-reoxygenation (OGD/R) were investigated using a Cell Counting Kit-8 assay, lactate dehydrogenase (LDH) assay, flow cytometry, quantitative polymerase chain reaction (qPCR), and western blotting to examine cellular viability, apoptosis, reactive oxygen species (ROS) levels, mRNA and protein levels, respectively, in relation to ERS and autophagy...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29374830/correlations-between-near-infrared-spectroscopy-perfusion-index-and-cardiac-outputs-in-extremely-preterm-infants-in-the-first-72%C3%A2-h-of-life
#7
Marie Janaillac, Thierry P Beausoleil, Keith J Barrington, Marie-Josée Raboisson, Oliver Karam, Mathieu Dehaes, Anie Lapointe
Haemodynamic assessment during the transitional period in preterm infants is challenging. We aimed to describe the relationships between cerebral regional tissue oxygen saturation (CrSO2), perfusion index (PI), echocardiographic, and clinical parameters in extremely preterm infants in their first 72 h of life. Twenty newborns born at < 28 weeks of gestation were continuously monitored with CrSO2 and preductal PI. Cardiac output was measured at H6, H24, H48, and H72. The median gestational age and birth weight were 25...
January 27, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29368759/ischemic-preconditioning-treatment-of-astrocytes-transfers-ischemic-tolerance-to-neurons
#8
Srinivasan V Narayanan, Miguel A Perez-Pinzon
Ischemic preconditioning (IPC) represents a potential therapy against cerebral ischemia. While our group has previously shown IPC to induce neuroprotection through various pathways, the role of astrocytes in supporting IPC-induced neuroprotection has not been extensively studied. Astrocyte-derived lactate has gained attention as a potential soluble mediator through which astrocytes could impart ischemic tolerance to neurons. Therefore, the goal of this study was to determine if i) IPC-treatment of astrocytes alone could transfer ischemic tolerance to neurons; ii) if IPC-treatment of astrocytes increases lactate production; and if iii) exogenous lactate administration to neurons could induce neuroprotection against lethal ischemia in vitro...
December 2017: Cond Med
https://www.readbyqxmd.com/read/29368635/cerebral-metabolic-effects-of-strict-versus-conventional-glycaemic-targets-following-severe-traumatic-brain-injury
#9
Mark P Plummer, Natalia Notkina, Ivan Timofeev, Peter J Hutchinson, Mark E Finnis, Arun K Gupta
BACKGROUND: Optimal glycaemic targets for patients with severe traumatic brain injury remain unclear. The primary objective of this microdialysis study was to compare cerebral metabolism with strict versus conventional glycaemic control. METHODS: We performed a prospective single-centre randomised controlled within-subject crossover study of 20 adult patients admitted to an academic neurointensive care unit with severe traumatic brain injury. Patients underwent randomised, consecutive 24-h periods of strict (4-7 mmol/L; 72-126 mg/dl) and conventional (<10 mmol/L; 180 mg/dl) glycaemic control with microdialysis measurements performed hourly...
January 25, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29363221/pretreatment-with-magnesium-sulfate-attenuates-white-matter-damage-by-preventing-cell-death-of-developing-oligodendrocytes
#10
Takahiro Seyama, Yoshimasa Kamei, Takayuki Iriyama, Shinya Imada, Mari Ichinose, Masatake Toshimitsu, Tomoyuki Fujii, Hiroaki Asou
AIM: Antenatal maternal administration of magnesium sulfate (MgSO4 ) reduces cerebral palsy in preterm infants. However, it remains controversial as to whether it also reduces occurrence of white matter damage, or periventricular leukomalacia. We assessed the effect of MgSO4 against white matter damage induced by hypoxic-ischemic insult using a neonatal rat model and culture of premyelinating oligodendrocytes (pre-OL). METHODS: Rat pups at postnatal day (P) 6 were administered either MgSO4 or vehicle intraperitoneally before hypoxic-ischemic insult (unilateral ligation of the carotid artery followed by 6% oxygen for 1 h)...
January 23, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29359243/neonatal-mitochondrial-leukoencephalopathy-with-brain-and-spinal-involvement-and-high-lactate-expanding-the-phenotype-of-isca2-gene-mutations
#11
Irene Toldo, Margherita Nosadini, Chiara Boscardin, Giacomo Talenti, Renzo Manara, Eleonora Lamantea, Andrea Legati, Daniele Ghezzi, Giorgio Perilongo, Stefano Sartori
A homoallelic missense founder mutation of the iron-sulfur cluster assembly 2 (ISCA2) gene has been recently reported in six cases affected by an autosomal recessive infantile neurodegenerative mitochondrial disorder. We documented a case of a 2-month-old girl presenting with severe hypotonia and nystagmus, who rapidly deteriorated and died at the age of three months. Increased cerebral spinal fluid level of lactate, documented also at the brain spectroscopy, involvement of the cortex, restricted diffusion of white and gray matter abnormalities, sparing of the corpus callosum and extensive involvement of the spinal cord were observed...
January 23, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29357480/no-evidence-for-direct-effects-of-recombinant-human-erythropoietin-on-cerebral-blood-flow-and-metabolism-in-healthy-humans
#12
Mark Bitsch Vestergaard, Otto Mølby Henriksen, Ulrich Lindberg, Niels Jacob Aachmann-Andersen, Kristian Lisbjerg, Søren Just Christensen, Niels Vidiendal Olsen, Ian Law, Henrik Bo Wiberg Larsson, Peter Rasmussen
Erythropoietin (EPO) is expressed in human brain tissue but the exact role is unknown. EPO may improve the efficiency of the oxidative metabolism and have neuroprotective properties against hypoxic injuries in animal models. We aimed to investigate the effect of recombinant human EPO (rHuEPO) administration on healthy cerebral metabolism in humans during normoxia and during metabolic stress by inhalation of 10% O2 hypoxic air. Twenty-four healthy males participated in a two-arm double-blind placebo-controlled trial...
January 11, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29346537/cerebral-mitochondrial-dysfunction-associated-with-deep-hypothermic-circulatory-arrest-in-neonatal-swine
#13
Constantine D Mavroudis, Michael Karlsson, Tiffany Ko, Marco Hefti, Javier I Gentile, Ryan W Morgan, Ross Plyler, Kobina G Mensah-Brown, Timothy W Boorady, Richard W Melchior, Tami M Rosenthal, Brandon C Shade, Kellie L Schiavo, Susan C Nicolson, Thomas L Spray, Robert M Sutton, Robert A Berg, Daniel J Licht, J William Gaynor, Todd J Kilbaugh
OBJECTIVES: Controversy remains regarding the use of deep hypothermic circulatory arrest (DHCA) in neonatal cardiac surgery. Alterations in cerebral mitochondrial bioenergetics are thought to contribute to ischaemia-reperfusion injury in DHCA. The purpose of this study was to compare cerebral mitochondrial bioenergetics for DHCA with deep hypothermic continuous perfusion using a neonatal swine model. METHODS: Twenty-four piglets (mean weight 3.8 kg) were placed on cardiopulmonary bypass (CPB): 10 underwent 40-min DHCA, following cooling to 18°C, 10 underwent 40 min DHCA and 10 remained at deep hypothermia for 40 min; animals were subsequently rewarmed to normothermia...
January 15, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29344937/ndufaf3-variants-that-disrupt-mitochondrial-complex-i-assembly-may-associate-with-cavitating-leukoencephalopathy
#14
A Ishiyama, K Muramatsu, S Uchino, C Sakai, Y Matsushima, N Makioka, T Ogata, E Suzuki, H Komaki, M Sasaki, M Mimaki, Y-I Goto, I Nishino
Genetic abnormalities in mitochondrial complex assembling factors are associated with leukoencephalopathy. We present a one-year-old girl with consciousness disturbance after a respiratory infection. Brain MRI revealed leukoencephalopathy with bilaterally symmetrical hyperintensity in the substantia nigra, medial thalamic nuclei, and basal nuclei, as well as cavities in the cerebral white matter and corpus callosum. Lactate levels in the spinal fluid were high, while magnetic resonance spectroscopy of the cerebral white matter and basal nuclei showed high peak lactate levels, suggesting mitochondrial dysfunction...
January 17, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29339713/neuroprotective-effect-of-selective-antegrade-cerebral-perfusion-during-prolonged-deep-hypothermic-circulatory-arrest-cerebral-metabolism-evidence-in-a-pig-model
#15
Zhixian Tang, Mengya Liang, Guangxian Chen, Jian Rong, Jianping Yao, Zhen Chen, Xiao Yang, Zhongkai Wu
OBJECTIVE: The aim of this study was to elucidate the mechanism of cerebral injury and to evaluate selective antegrade cerebral perfusion (SACP) as a superior neuroprotective strategy for prolonged deep hypothermic circulatory arrest (DHCA). METHODS: Twelve pigs (6-8-week old) were randomly assigned to DHCA alone (n=6) and DHCA with SACP (n=6) at 18°C for 80 min groups. Serum S100 was determined using an immunoassay analyzer. The concentrations of cerebral dialysate glucose, lactate, pyruvate, glycerol, and glutamate were measured using a microdialysis analyzer...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29328391/effects-of-thymosin-%C3%AE-4-on-oxygen%C3%A2-glucose-deprivation-and-reoxygenation%C3%A2-induced-injury
#16
Hua Ji, Linhao Xu, Zheng Wang, Xinli Fan, Lihui Wu
Cerebral ischemia causes severe brain injury and results in selective neuronal death through programmed cell death mechanisms, including apoptosis and autophagy. Minimizing neuronal injury has been considered a hot topic among clinicians. The present study elucidated the effect of thymosin β4 (Tβ4) on neuronal death induced by cerebral ischemia/reperfusion in PC12 cells that were subjected to oxygen‑glucose deprivation and reoxygenation (OGD/R). The survival, apoptotic and autophagy rates of PC12 cells were investigated...
January 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29287672/-impact-of-hypotension-and-global-hypoperfusion-in-postoperative-delirium-a-pilot-study-in-older-adults-undergoing-open-colon-surgery
#17
Eduardo Tobar, Mario A Abedrapo, Jaime A Godoy, Jose L Llanos, Mauricio J Díaz, Rodrigo Azolas, Gunther R Bocic, Jaime A Escobar, Rodrigo A Cornejo, Carlos M Romero
BACKGROUND: Post-operative delirium is a serious complication in patients undergoing major abdominal surgery. It remains unclear whether peri-operative hemodynamic and perfusion variables affect the risk for postoperative delirium. The objective of this pilot study was to evaluate the association between perfusion and hemodynamics peri-operative with the appearance of post-operative delirium. METHODS: Prospective cohort study of adults 60 years or older undergoing elective open colon surgery...
December 26, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29260243/-perioperative-handling-of-antidiabetic-drugs
#18
REVIEW
J Wagner, V Luber, J F Lock, U A Dietz, S Lichthardt, N Matthes, K Krajinovic, C-T Germer, S Knop, A Wiegering
Diabetes mellitus is the most frequent metabolic disorder in the western world with a prevalence of 3% in adults under 65 years of age and 14.3% in adults over 65 years of age. Due to the increasing age of our population, the number of patients taking oral antidiabetic drugs has increased. Thus, operating physicians must make a risk-adapted decision whether the medication can be continued perioperatively or if certain drugs must be paused, and if so, with what risks. Operative interventions can lead to a number of metabolic shifts, which change the normal glucose metabolism...
December 19, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29250148/changes-in-plasma-von-willebrand-factor-and-von-willebrand-factor-cleaving-protease-in-thrombotic-thrombocytopenic-purpura-a-case-report
#19
Yu Gao, Liping Wang, Guangxian Nan
The present case report described a patient with thrombotic thrombocytopenic purpura (TTP), who presented to the China-Japan Union Hospital of Jilin University (Changchun, China), and the changes in plasma von Willebrand factor (vWF) and vWF cleaving protease (vWF-cp) observed during treatment. Computed tomography and diffusion-weighted magnetic resonance (MR) imaging of the brain, cerebral MR angiography and other experimental tests were performed and the patient was subsequently diagnosed with TTP. The patient underwent treatment with plasma exchange, glucocorticoids and supportive care...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29248780/correlation-of-lactate-concentration-in-peripheral-plasma-and-cerebrospinal-fluid-with-glasgow-outcome-scale-for-tuberculous-meningitis-patients-complicated-by-acute-hydrocephalus-treated-with-fluid-diversions
#20
Ahmad Faried, Gusman Arief, Muhammad Z Arifin, Heda M Nataprawira
Tuberculous meningitis (TBM) is an endemic infectious disease in developing countries, and it can become a serious illness in children. TBM treatment is more difficult and prone to failure than lung TB. TBM causes hydrocephalus, cerebral edema, increased intracranial pressure, global ischemia and neurological deficits, which disturb cellular metabolism and increase lactate levels. Therefore, a reliable and widely available clinical indicator of TBM severity is needed. Successful treatment of TBM is assessed using the Glasgow outcome scale (GOS)...
December 14, 2017: World Neurosurgery
keyword
keyword
100077
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"