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https://www.readbyqxmd.com/read/29031906/suckling-induced-insulin-like-growth-factor-1-igf-1-release-in-mother-rats
#1
András H Lékó, Melinda Cservenák, Árpád Dobolyi
OBJECTIVE: Lactation involves significant neuroendocrine changes. The elevated prolactin (PRL) release from the pituitary, induced markedly by suckling, is the most relevant example. Suckling also causes a significant and rapid elevation in growth hormone (GH) levels. GH is necessary for milk synthesis as milk yield is stopped completely in the absence of PRL and GH, while the absence of PRL alone causes only a 50% reduction. Insulin-like growth factor-1 (IGF-1) plays an important role in the GH axis...
October 10, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29031393/cytokine-distribution-in-mothers-and-breastfed-children-after-omega-3-lcpufas-supplementation-during-the-last-trimester-of-pregnancy-and-the-lactation-period-a-randomized-controlled-trial
#2
Y Rodriguez-Santana, J J Ochoa, F Lara-Villoslada, N Kajarabille, P Saavedra-Santana, J A Hurtado, M Peña, J Diaz-Castro, I Sebastian-Garcia, E Machin-Martin, M Villanueva, O Ramirez-Garcia, L Peña-Quintana
OBJECTIVE: To determine whether maternal diet supplementation with omega-3 long chain polyunsaturated fatty acids (omega-3 LC-PUFAs) during the last trimester of pregnancy and the breastfeeding period influences the levels of inflammatory cytokines in mother and infants. MATERIAL AND METHOD: This registered, double-blind randomized study included 46 pregnant women, who were randomly allocated to either an experimental group receiving 400mL/day of a fish oil-enriched dairy drink [320mg docosahexaenoic acid (DHA) + 72mg eicoapentaenoic acid] (FO group, n = 24) or to a control group receiving 400mL/day of a non-supplemented dairy drink (CT group, n = 22), from week 28 of pregnancy until the fourth month of lactation...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29018323/cerebrospinal-fluid-amino-acid-profiling-of-pediatric-cases-with-tuberculous-meningitis
#3
Shayne Mason, Carolus J Reinecke, Regan Solomons
Background: In Africa, tuberculosis is generally regarded as persisting as one of the most devastating infectious diseases. The pediatric population is particularly vulnerable, with infection of the brain in the form of tuberculous meningitis (TBM) being the most severe manifestation. TBM is often difficult to diagnose in its early stages because of its non-specific clinical presentation. Of particular concern is that late diagnosis, and subsequent delayed treatment, leads to high risk of long-term neurological sequelae, and even death...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28994628/effects-of-total-flavonoids-of-sea-buckthorn-hippophae-rhamnoides-l-on-cytotoxicity-of-nk92-mi-cells
#4
Diandong Hou, Decheng Wang, Xiande Ma, Wenna Chen, Shengnan Guo, Hongquan Guan
Sea buckthorn ( Hippophae rhamnoides L.) has multifarious medicinal properties including immunoregulatory effect. The total flavonoids of Hippophae rhamnoides L. (TFH) are the main active components isolated from berries of sea buckthorn. The aim of this study was to evaluate the effects of TFH on the cytotoxicity of NK92-MI cells and its possible mechanisms. NK92-MI cells were treated with TFH (2.5 or 5.0 mg/L) or phosphate-buffered saline (PBS) for 24 h, the cytotoxicity against K562 was detected by measuring the release of lactate dehydrogenase (LDH), expression levels of NCRs (NKp30, NKp44, NKp46) and NKG2D were detected by flow cytometry, and expression levels of perforin and granzyme B were detected by western blot...
October 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28933272/evaluation-of-metabolic-and-synaptic-dysfunction-hypotheses-of-alzheimer-s-disease-ad-a-meta-analysis-of-csf-markers
#5
Roni Manyevitch, Matthew Protas, Sean Scarpiello, Marisa Deliso, Brittany Bass, Anthony Nanajian, Matthew Chang, Stefani M Thompson, Neil Khoury, Rachel Gonnella, Margit Trotz, D Blaine Moore, Emily Harms, George Perry, Lucy Clunes, Angélica Ortiz, Jan O Friedrich, Ian V J Murray
BACKGROUND: Alzheimer's disease (AD) is currently incurable and a majority of investigational drugs have failed clinical trials. One explanation for this failure may be the invalidity of hypotheses focusing on amyloid to explain AD pathogenesis. Recently, hypotheses which are centered on synaptic and metabolic dysfunction are increasingly implicated in AD. OBJECTIVE: Evaluate AD hypotheses by comparing neurotransmitter and metabolite marker concentrations in normal versus AD CSF...
September 21, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28927127/vascular-endothelial-growth-factor-and-protein-level-in-pleural-effusion-for-differentiating-malignant-from-benign-pleural-effusion
#6
Da-Wei Wu, Wei-An Chang, Kuan-Ting Liu, Meng-Chi Yen, Po-Lin Kuo
Pleural effusion is associated with multiple benign and malignant conditions. Currently no biomarkers differentiate malignant pleural effusion (MPE) and benign pleural effusion (BPE) sensitively and specifically. The present study identified a novel combination of biomarkers in pleural effusion for differentiating MPE from BPE by enrolling 75 patients, 34 with BPE and 41 with MPE. The levels of lactate dehydrogenase, glucose, protein, and total cell, neutrophil, monocyte and lymphocyte counts in the pleural effusion were measured...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28916229/japanese-leigh-syndrome-case-treated-with-epi-743
#7
Takeshi Kouga, Mariko Takagi, Akihiko Miyauchi, Hiroko Shimbo, Mizue Iai, Sumimasa Yamashita, Kei Murayama, Matthew B Klein, Guy Miller, Tomohide Goto, Hitoshi Osaka
BACKGROUND: Leigh syndrome is a mitochondrial disease caused by respiratory chain deficiency, and there are no proven effective therapies. EPI-743 is a potent cellular oxidative stress protectant and results of clinical trials for mitochondrial diseases are accumulating. CASE: At 5months, a girl presented with the scarce eye movement and diminished muscle tone. She was diagnosed with Leigh encephalopathy from blood and cerebrospinal fluid lactate elevation and MRI findings...
September 12, 2017: Brain & Development
https://www.readbyqxmd.com/read/28892414/efficacy-of-recombinant-adenovirus-expressing-a-fusion-gene-from-gm-csf-and-epstein-barr-virus-lmp2a-in-a-mouse-tumor-model
#8
Qingjie Xue, Xiuzhen Li, Chunqing Yang, Bingyuan Ji, Yunqing Li, Yingchun Yan, Xinxin Yang, Chunmei Wang, Ting Chen
In this study, purified GM-CSF and LMP2A mRNAs were amplified by PCR. Then, the GM-CSF and LMP2A sequences were connected by the polypeptide linker (Gly4Ser)3 using gene splicing by overlap extension. The constructed fusion gene GC2A was inserted into the adenovirus vector. Then the recombinant vector was introduced into HEK 293T cells by calcium phosphate transfection to package the adenovirus. The levels of antibodies against the GM-CSF and LMP2Afusion proteins were measured by ELISA, and the CTL activity of the mouse splenic lymphocytes was determined by lactate dehydrogenase (LDH) release assay...
October 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28866321/cerebrospinal-fluid-lactate-a-differential-biomarker-for-bacterial-and-viral-meningitis-in-children
#9
Mudasir Nazir, Wasim Ahmad Wani, Muzaffar Ahmad Malik, Mohd Rafiq Mir, Younis Ashraf, Khalid Kawoosa, Syed Wajid Ali
OBJECTIVE: To assess the performance of cerebrospinal fluid (CSF) lactate as a biomarker to differentiate bacterial meningitis from viral meningitis in children, and to define an optimal CSF lactate concentration that can be called significant for the differentiation. METHODS: Children with clinical findings compatible with meningitis were studied. CSF lactate and other conventional CSF parameters were recorded. RESULTS: At a cut-off value of 3mmol/L, CSF lactate had a sensitivity of 0...
August 30, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28864170/flag-ida-regimen-as-bridge-therapy-to-allotransplantation-in-refractory-relapsed-acute-myeloid-leukemia-patients
#10
Mario Delia, Domenico Pastore, Paola Carluccio, Crescenza Pasciolla, Alessandra Ricco, Antonella Russo Rossi, Paola Casieri, Anna Mestice, Francesco Albano, Giorgina Specchia
BACKGROUND: Patients with primary refractory or first relapse acute myeloid leukemia (AML) are considered to have worse clinical outcomes after treatment. For these patients, the achievement of complete remission appears crucial for them to be able to undergo allotransplantation, which might be the only possible treatment. PATIENTS AND METHODS: We used the FLAG-Ida (fludarabine, cytarabine [cytosine arabinoside], granulocyte colony-stimulating factor, idarubicin) regimen in patients with primary refractory/first relapse AML as a bridge to transplantation...
June 19, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28858084/diagnostic-value-of-lactate-procalcitonin-ferritin-serum-c-reactive-protein-and-other-biomarkers-in-bacterial-and-viral-meningitis-a-cross-sectional-study
#11
Anahita Sanaei Dashti, Shekoofan Alizadeh, Abdullah Karimi, Masoomeh Khalifeh, Seyed Abdolmajid Shoja
There are many difficulties distinguishing bacterial from viral meningitis that could be reasonably solved using biomarkers. The aim of this study was to evaluate lactate, procalcitonin (PCT), ferritin, serum-CRP (C-reactive protein), and other known biomarkers in differentiating bacterial meningitis from viral meningitis in children.All children aged 28 days to 14 years with suspected meningitis who were admitted to Mofid Children's Hospital, Tehran, between October 2012 and November 2013, were enrolled in this prospective cross-sectional study...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28813252/oxytocin-a-parenting-hormone
#12
REVIEW
Ruth Feldman, Marian J Bakermans-Kranenburg
In non-human mammals mothering is hormone-dependent, with crucial roles for oxytocin and prolactin. While human parenting is not hormone-dependent, hormonal changes in oxytocin, vasopressin, prolactin, testosterone, and cortisol prime and accompany the expression of parenting. In the following we focus on oxytocin (OT) as a key hormone in human parenting. OT is a nine-amino-acid neuropeptide hormone which evolved from the ancient vasotocin molecule approximately 650 MYO. OT is implicated in sociality across vertebrate evolution and substantial research has pinpointed its role in birth, lactation, and maternal care in mammals...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28804760/autopsy-case-of-the-c12orf65-mutation-in-a-patient-with-signs-of-mitochondrial-dysfunction
#13
Hideaki Nishihara, Masatoshi Omoto, Masaki Takao, Yujiro Higuchi, Michiaki Koga, Motoharu Kawai, Hiroo Kawano, Eiji Ikeda, Hiroshi Takashima, Takashi Kanda
OBJECTIVE: To describe the autopsy case of a patient with a homozygous 2-base deletion, c171_172delGA (p.N58fs), in the C12orf65 gene. METHODS: We described the clinical history, neuroimaging data, neuropathology, and genetic analysis of the patients with C12orf65 mutations. RESULTS: The patient was a Japanese woman with a history of delayed psychomotor development, primary amenorrhea, and gait disturbance in her 20s. She was hospitalized because of respiratory failure at the age of 60...
August 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28797088/csf-profile-in-primary-progressive-multiple-sclerosis-re-exploring-the-basics
#14
Ahmed Abdelhak, Tilman Hottenrott, Christoph Mayer, Gudrun Hintereder, Uwe K Zettl, Oliver Stich, Hayrettin Tumani
OBJECTIVE: The aim of this study was to report the basic cerebrospinal fluid (CSF) profile in patients with primary progressive multiple sclerosis (PPMS). METHODS: The results of CSF analysis from 254 patients with PPMS were collected at four university hospitals in Germany. Routine CSF parameters and different indices of intrathecal immunoglobulin synthesis were evaluated. We assessed possible correlations between the various CSF parameters and the expanded disability status scale (EDSS) both at the time of lumbar puncture and during the course of the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28789958/diagnosis-of-ventriculostomy-related-infection-is-cerebrospinal-fluid-lactate-measurement-a-useful-tool
#15
Pedro Grille, Federico Verga, Alberto Biestro
OBJECTIVE: To evaluate the value of CSF lactate (LCSF) for the diagnosis of ventriculostomy related infections (VRI), and compare it with other CSF markers. METHODS: Prospective study of neurocritical patients admitted to Maciel Hospital and Clinicas Hospital ICUs in which an external ventricular drain (EVD) was inserted. In patients with clinical suspicion of VRI, a CSF sample was obtained through the EVD for CSF culture and markers analysis (glucose, protein, lactate and leukocytes)...
November 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28770205/fatal-mycotic-aneurysm-of-the-basilar-artery-caused-by-aspergillus-fumigatus-in-a-patient-with-pituitary-adenoma-and-meningitis
#16
Martin Winterholler, Roland Coras, Walter Geißdörfer, Rudolf Rammensee, Philipp Gölitz, Christian Bogdan, Roland Lang
Fungal infections of the central nervous system (CNS) frequently occur in immunosuppressed patients. Here, we describe the case of an immunocompetent 64-year-old man who presented with diplopia, right-sided hemiparesis, and a mild headache after cleaning and replacing nesting boxes of wild birds during the preceding months. Lumbar puncture revealed pleocytosis, elevated protein, and lactate levels in the cerebrospinal fluid (CSF). Initial imaging showed ischemia in the left thalamus and an enlargement of the sellar region...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28758186/the-causes-of-post-operative-meningitis-the-comparison-of-gram-negative-and-gram-positive-pathogens
#17
Behice Kurtaran, Ferit Kuscu, Aslihan Ulu, Ayse Seza Inal, Suheyla Komur, Filiz Kibar, Nuri Eralp Cetinalp, Kerem Mazhar Ozsoy, Yusuf Kemal Arslan, Hasan Salih Aksu, Yesim Tasova
AIM: In this study, we aim to determine the microbiological etiology in critically ill neurosurgical patients with nosocomial meningitis (NM) and show the impact of Gram-negative rods and differences of patient's characteristics, clinical and prognostic measures between Gram-negative and Gram-positive meningitis. MATERIAL AND METHODS: In this prospective, one center study we reviewed all adult patients hospitalized during a 12-year period and identified pathogens isolated from post-neurosurgical cases of NM...
June 20, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28755360/mitochondrial-encephalopathy-and-transient-3-methylglutaconic-aciduria-in-echs1-deficiency-long-term-follow-up
#18
Irene C Huffnagel, Egbert J W Redeker, Liesbeth Reneman, Frédéric M Vaz, Sacha Ferdinandusse, Bwee Tien Poll-The
We report the major diagnostic challenge in a female patient with signs and symptoms suggestive of an early-onset mitochondrial encephalopathy. Motor and cognitive development was severely delayed and brain MRI showed signal abnormalities in the putamen and caudate nuclei. Metabolic abnormalities included 3-methylglutaconic aciduria and elevated lactate levels in plasma and cerebrospinal fluid, but were transient. Whole exome sequencing at the age of 25 years finally revealed compound heterozygous mutations c...
July 29, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28746356/metabolomic-profiling-of-csf-in-multiple-sclerosis-and-neuromyelitis-optica-spectrum-disorder-by-nuclear-magnetic-resonance
#19
Hyun-Hwi Kim, In Hye Jeong, Ja-Shil Hyun, Byung Soo Kong, Ho Jin Kim, Sung Jean Park
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory diseases of the central nervous system. Although several studies have characterized the metabolome in the cerebrospinal fluid (CSF) from MS and NMOSD patients, comparative analyses between them and between the relapse and the remission of each disease have not been performed. Both univariate and multivariate analyses were used to compare 1H-NMR spectra of CSF from MS, NMOSD, and healthy controls (HCs). The statistical analysis showed alterations of eight metabolites that were dependent on the disease...
2017: PloS One
https://www.readbyqxmd.com/read/28739363/involvement-of-cerebellum-in-leigh-syndrome-case-report-and-review-of-the-literature
#20
Nitish Chourasia, Rahmat B Adejumo, Rajan P Patel, Mary Kay Koenig
BACKGROUND: Leigh syndrome is an early-onset progressive neurodegenerative disorder typically involving lesions of the bilateral basal ganglia, thalami, and brainstem. Isolated involvement of the cerebellum is uncommon. PATIENT DESCRIPTION: We present a six-year-old boy with Leigh syndrome who presented with recurrent episodes of ataxia and dysarthria. He was diagnosed with Leigh syndrome at two years of age with bilateral basal ganglia lesions on brain magnetic resonance imaging (MRI)...
September 2017: Pediatric Neurology
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