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https://www.readbyqxmd.com/read/29054125/external-validation-of-a-cancer-risk-prediction-model-for-suspected-head-and-neck-cancer-referrals
#1
T Tikka, V Paleri, K MacKenzie
Head and neck cancer (HNC) affects more than 9000 new patients every year in England and Wales with an additional 1200 in Scotland. (1,2) Patients are urgently referred to head and neck clinics for further assessment when a suspicion of cancer is raised in the primary care setting. In England, the referral criteria are based on the NICE recommendations for symptoms associated with HNC. (2) A different combination of symptoms is described in the Scottish cancer referral guidelines. (3) There is currently no unified referral proforma across the different UK cancer networks...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29053803/effect-of-radiation-on-sucrose-detection-thresholds-of-mice
#2
Benjamin C Jewkes, Linda A Barlow, Eugene R Delay
Radiotherapy is one of the most common treatments for head and neck cancers, with an almost obligate side effect of altered taste (Conger 1973). In mice, targeted irradiation of the head and neck causes transient repression of proliferation of basal epithelial cells responsible for taste cell replacement, leading to a temporary depletion of taste sensory cells within taste buds, including Type II taste cells involved in detection of sweet stimuli (Nguyen et al. 2012). These findings suggest that irradiation may elevate sucrose detection thresholds, peaking at 7 days post-irradiation when loss of Type II cells is greatest...
October 19, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29053184/the-tumor-genome-in-human-immunodeficiency-virus-related-head-and-neck-cancer-exploitable-targets
#3
EDITORIAL
Barbara Burtness
No abstract text is available yet for this article.
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29053175/distinct-pattern-of-tp53-mutations-in-human-immunodeficiency-virus-related-head-and-neck-squamous-cell-carcinoma
#4
Frederico O Gleber-Netto, Mei Zhao, Sanchit Trivedi, Jiping Wang, Samar Jasser, Christina McDowell, Humam Kadara, Jiexin Zhang, Jing Wang, William N William, J Jack Lee, Minh Ly Nguyen, Sara I Pai, Heather M Walline, Dong M Shin, Robert L Ferris, Thomas E Carey, Jeffrey N Myers, Curtis R Pickering
BACKGROUND: Human immunodeficiency virus-infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), and clinical and histopathological differences have been observed in their tumors in comparison with those of HNSCC patients without a human immunodeficiency virus (HIV) infection. The reasons for these differences are not clear, and molecular differences between HIV-related HNSCC and non-HIV-related HNSCC may exist. This study compared the mutational patterns of HIV-related HNSCC and non-HIV-related HNSCC...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29050538/evaluation-of-the-head-and-neck-cancer-patient-population-and-the-incidence-of-hospitalization-at-an-academic-medical-center
#5
Lindsay A Hazelden, Matthew J Newman, Stephanie Shuey, Julie M Waldfogel, Victoria T Brown
Purpose Patients with head and neck cancer are at risk for disease- and treatment-related toxicities that may be severe enough to require hospitalization. The risk factors associated with hospitalization in these patients are not well defined. Methods We conducted a single-center, retrospective observational study of patients with head and neck cancer receiving chemotherapy at an academic medical center infusion clinic in a one-year period. The primary objective was to characterize the head and neck cancer population at an academic medical center...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29049027/atlas-ranking-and-selection-for-automatic-segmentation-of-the-esophagus-from-ct-scans
#6
Jinzhong Yang, Benjamin Haas, Raymond Fang, Beth B Beadle, Adam S Garden, Zhongxing Liao, Lifei Zhang, Peter A Balter, Laurence E Court
In radiation treatment planning, the esophagus is an important organ-at-risk that should be spared in patients with head and neck cancer or thoracic cancer who undergo intensity-modulated radiation therapy. However, automatic segmentation of the esophagus from CT scans is extremely challenging because of the structure's inconsistent intensity, low contrast against the surrounding tissues, complex and variable shape and location, and random air bubbles. The goal of this study is to develop an online atlas selection approach to choose a subset of optimal atlases for multi-atlas segmentation to delineate esophagus automatically...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29048671/adoptive-immunotherapy-combined-with-fp-treatment-for-head-and-neck-cancer-an-in%C3%A2-vitro-study
#7
Mayako Nishio-Nagai, Susumu Suzuki, Kazuhiro Yoshikawa, Ryuzo Ueda, Yoshiaki Kazaoka
FP treatment, which combines 5-fluorouracil (5-FU) and cisplatin (CDDP) chemotherapy, is widely used for treatment of advanced head and neck cancer (HNC). It has been suggested that these drugs cause immunomodulation in the cancer microenvironment, for example, downregulation of immunosuppressive cells such as regulatory T-cells (Tregs) and myeloid-derived suppressive cells (MDSCs), activating dendritic cells (DCs), and upregulation of tumor antigens and major histocompatibility complex (MHC) molecules in cancer cells leads to enhancement of cancer immunity, which is important in cancer treatment, as well as providing a direct killing effect...
October 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29044881/local-control-in-sinonasal-malignant-melanoma-comparing-conventional-to-hypofractionated-radiotherapy
#8
Jules Lansu, Willem Martin Klop, Wilma Heemsbergen, Arash Navran, Abrahim Al-Mamgani, Johannes A Langendijk, Johannes H Kaanders, Chris Terhaard, Baris Karakullukcu, Olga Hamming-Vrieze
BACKGROUND: The purpose of this study was to analyze the effect of fractionation schedule on local control in postoperative radiotherapy (RT) for sinonasal malignant melanoma. METHODS: Sixty-three patients who were treated with surgery and postoperative RT in 4 accredited head and neck cancer centers in the Netherlands between 1998 and 2013 were retrospectively studied. Outcomes with conventional fractionation (2-2.4 Gy per fraction; n = 27) were compared to hypofractionation (4-6 Gy per fraction; n = 36)...
October 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/29044879/exercise-therapy-for-trismus-secondary-to-head-and-neck-cancer-a-systematic-review
#9
Jolanda I Kamstra, Marianne van Leeuwen, Jan L N Roodenburg, Pieter U Dijkstra
BACKGROUND: Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004. METHODS: Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. RESULTS: Two hundred eleven articles were found, 20 studies were included. A large variation in research methodology, stretching techniques, duration of stretch, and repetition of exercises was found...
November 2017: Head & Neck
https://www.readbyqxmd.com/read/29044631/frailty-hospital-volume-and-failure-to-rescue-after-head-and-neck-cancer-surgery
#10
Carrie L Nieman, C Matthew Stewart, David W Eisele, Peter J Pronovost, Christine G Gourin
OBJECTIVES/HYPOTHESIS: We previously reported that high-volume hospital head and neck cancer (HNCA) surgical care is associated with decreased mortality, largely explained by reduced rates of failure to rescue. Frailty is an independent predictor of mortality, but is significantly less likely in patients receiving high-volume care. We investigate whether differences in frailty rates explain the relationship between volume and outcomes in HNCA patients and whether frailty confounds the relationship between failure to rescue and mortality...
October 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29039234/risk-of-development-of-second-primary-head-and-neck-cancer-following-an-index-breast-cancer
#11
Jessica Yesensky, Alexandra Kyrillos, Kristine Kuchta, Katharine Yao, Chi-Hsiung Wang, Mihir K Bhayani
Objective Many head and neck cancers (HNCs) have genomic features seen in breast malignancy. We sought to analyze the risk of second primary HNC following an index breast cancer. Study Design Retrospective cohort study. Setting National database from the SEER registry (Surveillance, Epidemiology, and End Results). Subjects and Methods Within the SEER database, 223,423 women diagnosed with index breast cancer from 1992 to 2002 were identified. We calculated standard incidence ratios (SIRs) for all head and neck sites with 10-year follow-up...
October 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29038438/haplotype-analysis-of-xrcc2-gene-polymorphisms-and-association-with-increased-risk-of-head-and-neck-cancer
#12
Soma Saeed, Ishrat Mahjabeen, Romana Sarwar, Kashif Bashir, Mahmood Akhtar Kayani
We aimed to investigate the effect of hotspot variations of XRCC2 gene on the risk of head and neck cancer (HNC) in 400 patients and 400 controls. Five polymorphisms of XRCC2 gene G4234C (rs3218384), G4088T (rs3218373), G3063A (rs2040639), R188H (rs3218536) and rs7802034 were analyzed using Allele- specific polymerase chain reaction (ARMS-PCR) followed by sequence analysis. For rs3218373, the GG genotype indicated a statistically significant 3-fold increased risk of HNC (P < 0.001) after multivariate adjustment...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037457/epidemiology-and-burden-of-hpv-related-disease
#13
REVIEW
Beatriz Serrano, María Brotons, Francesc Xavier Bosch, Laia Bruni
Human papillomavirus (HPV) infection is recognized as one of the major causes of infection-related cancer in both men and women. High-risk HPV types are not only responsible for virtually all cervical cancer cases but also for a fraction of cancers of the vulva, vagina, penis, anus, and head and neck cancers. Furthermore, HPV is also the cause of anogenital warts and recurrent respiratory papillomatosis. Despite the availability of multiple preventative strategies, HPV-related cancer remains a leading cause of morbi-mortality in many parts of the world, particularly in less developed countries...
September 2, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29036167/development-and-validation-of-a-protocol-for-optimizing-the-use-of-paraffin-blocks-in-molecular-epidemiological-studies-the-example-from-the-hpv-ahead-study
#14
MULTICENTER STUDY
Marisa Mena, Belen Lloveras, Sara Tous, Johannes Bogers, Fausto Maffini, Nitin Gangane, Rekha Vijay Kumar, Thara Somanathan, Eric Lucas, Devasena Anantharaman, Tarik Gheit, Xavier Castellsagué, Michael Pawlita, Silvia de Sanjosé, Laia Alemany, Massimo Tommasino
Worldwide use of formalin-fixed paraffin-embedded blocks (FFPE) is extensive in diagnosis and research. Yet, there is a lack of optimized/standardized protocols to process the blocks and verify the quality and presence of the targeted tissue. In the context of an international study on head and neck cancer (HNC)-HPV-AHEAD, a standardized protocol for optimizing the use of FFPEs in molecular epidemiology was developed and validated. First, a protocol for sectioning the FFPE was developed to prevent cross-contamination and distributed between participating centers...
2017: PloS One
https://www.readbyqxmd.com/read/29034444/mage-a11-expression-contributes-to-cisplatin-resistance-in-head-and-neck-cancer
#15
Stefan Hartmann, Leonie Zwick, Mario J J Scheurer, Andreas R Fuchs, Roman C Brands, Axel Seher, Hartmut Böhm, Alexander C Kübler, Urs D A Müller-Richter
OBJECTIVE: The objective of this study is to investigate the roles of melanoma-associated antigens (MAGEs) in the cisplatin treatment of head and neck cancer. MATERIALS AND METHODS: We assessed the efficacy of cisplatin in a set of four head and neck cancer cell lines using a crystal violet assay. The MAGE-A expression in all cell lines was measured with RT-qPCR. The correlation between MAGE-A expression and cisplatin efficacy was investigated using Spearman's correlation analysis...
October 15, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29031363/chapter-1-neck-anatomy-imaging-based-level-nodal-classification-and-impact-of-primary-tumor-site-on-patterns-of-nodal-metastasis
#16
Matthew H Kulzer, Barton F Branstetter
The anatomy of the neck is complex, with many critical structures crowded together in a relatively small cross-sectional area. Many structures in the neck also have similar soft tissue density or signal that further complicates interpretation for the radiologist, who relies on tissue differences to create contrast resolution and distinguish structures. Head and neck cancer incidence exceeds 550,000 cases per year worldwide, with diagnosis, treatment, and prognosis relying highly on a thorough knowledge of this compact space...
October 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29031310/in-a-bad-place-carers-of-patients-with-head-and-neck-cancer-experiences-of-travelling-for-cancer-treatment
#17
Myles Balfe, Kieran Keohane, Katie O' Brien, Rachael Gooberman-Hill, Rebecca Maguire, Paul Hanly, Eleanor O' Sullivan, Linda Sharp
PURPOSE: To explore the effect that treatment-related commuting has on carers of patients with head and neck cancer. METHOD: Semi-structured interviews, thematically analysed, with 31 carers. RESULTS: Treatment-related commuting had a considerable impact on carers of patients with head and neck cancer, both in practical terms (economic costs, disruption) and also in psychological terms. Many carers of patients with head and neck cancer described becoming distressed by their commute...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29030020/the-trajectory-of-positive-psychological-change-in-a-head-and-neck-cancer-population
#18
S A Harding
A stressful event may be sufficient to challenge a strongly held set of assumptions about the world and the self. In some people this may lead to post-traumatic stress disorder (PTSD) and in others to positive psychological change (PPC), whereby a person's reactions to the challenge are beneficial. Little research has investigated PPC in people who have had head and neck cancer (HNC). The aim of this study was to identify demographic, clinical, and psychological factors associated with PPC over time. A cross-sequential study collected data over 5 years...
October 10, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29029767/pet-ct-and-pet-mri-in-head-and-neck-malignancy
#19
REVIEW
T A Szyszko, G J R Cook
Combined 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3-6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillance and those who underwent planned neck dissection, but surveillance was more cost-effective...
October 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29029645/on-the-implications-of-desexualizing-vaccines-against-sexually-transmitted-diseases-reflections-from-a-practicing-pediatrician
#20
Amanda F Dempsey
Human papillomavirus (HPV) vaccination holds great promise for drastically reducing the incidence of HPV-associated cancers of the genital tract, and possibly also certain head and neck cancers. Unfortunately, rates of HPV vaccine utilization among adolescents are low in many countries. Many research studies have identified the fact that HPV is a sexually transmitted infection as a barrier to higher vaccination rates. This is related to providers' and parents' reluctance to discuss or consider the burgeoning sexuality of their child...
October 13, 2017: Israel Journal of Health Policy Research
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