keyword
MENU ▼
Read by QxMD icon Read
search

"head and neck cancer"

keyword
https://www.readbyqxmd.com/read/28225567/randomized-controlled-trial-of-a-multisite-speech-pathology-telepractice-service-providing-swallowing-and-communication-intervention-to-patients-with-head-and-neck-cancer-evaluation-of-service-outcomes
#1
Clare L Burns, Elizabeth C Ward, Anne J Hill, Sanjeewa Kularatna, Joshua Byrnes, Lizbeth M Kenny
BACKGROUND: The purpose of this study was to present our evaluation of a new speech pathology telepractice service supporting the swallowing and communication management of patients with head and neck cancer. METHODS: A multicenter randomized controlled trial was conducted within a large public cancer service. Referrals from speech pathologists at 3 regional sites (spoke sites) were managed by a specialist clinician from a cancer center (hub site) either via standard care (phone/email support/appointments at the hub site) or a newly established telepractice service (online consultation between the hub site and spoke site)...
February 22, 2017: Head & Neck
https://www.readbyqxmd.com/read/28222111/a-meta-analysis-of-the-abscopal-effect-in-preclinical-models-is-the-biologically-effective-dose-a-relevant-physical-trigger
#2
Raffaella Marconi, Silvia Strolin, Gianluca Bossi, Lidia Strigari
BACKGROUND: Preclinical in vivo studies using small animals are considered crucial in translational cancer research and clinical implementation of novel treatments. This is of paramount relevance in radiobiology, especially for any technological developments permitted to deliver high doses in single or oligo-fractionated regimens, such as stereotactic ablative radiotherapy (SABR). In this context, clinical success in cancer treatment needs to be guaranteed, sparing normal tissue and preventing the potential spread of disease or local recurrence...
2017: PloS One
https://www.readbyqxmd.com/read/28221700/multikinase-inhibitors-sorafenib-and-sunitinib-as-radiosensitizers-in-head-and-neck-cancer-cell-lines
#3
Annette Affolter, Gerson Samosny, Anne-Sophie Heimes, Johanna Schneider, Wilko Weichert, Albrecht Stenzinger, Katharina Sommer, Alexandra Jensen, Arnulf Mayer, Walburgis Brenner, Wolf J Mann, Jürgen Brieger
BACKGROUND: Radioresistance is a common feature of head and neck squamous cell carcinoma (HNSCC). We previously showed that the irradiation- activated vascular endothelial growth factor (VEGF)-extracellular signal-regulated kinase (ERK)-axis is fundamental for the survival of resistant tumors. In this study, we examined if treatment with potent multikinase (MK) inhibitors, sorafenib and sunitinib, could radiosensitize tumor cells. METHODS: Cultured HNSCC cell lines were treated with inhibitors and subsequently irradiated...
February 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/28220985/the-head-and-neck-cancer-patient-concern-inventory-%C3%A2-patient-concerns-prevalence-dental-concerns-impact-and-relationships-of-concerns-with-quality-of-life-measures
#4
Maria L Aguilar, Pamela Sandow, John W Werning, Lia Brenneman, Walter J Psoter
PURPOSE: The Patient Concern Inventory(©) (PCI) is a clinical tool of self-reported patient concerns to be used by the clinician to structure the patient-oncologist visit. It was developed in the United Kingdom to address the issues of quality of life (QOL) in head and neck cancer (HNC) patients. The purpose of the study reported here was to determine the prevalence of PCI(©) items, the associations between PCI(©) items and QOL, and to explore the importance of oral/dental issues in the patient's well-being...
February 21, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28219368/lower-blood-pressure-and-risk-of-cisplatin-nephrotoxicity-a-retrospective-cohort-study
#5
Kazumi Komaki, Tetsuro Kusaba, Mai Tanaka, Hiroshi Kado, Yayoi Shiotsu, Masahiro Matsui, Atsushi Shiozaki, Hiroshi Nakano, Takeshi Ishikawa, Hitoshi Fujiwara, Hideyuki Konishi, Yoshito Itoh, Satoaki Matoba, Keiichi Tamagaki
BACKGROUND: The pathophysiological mechanisms of cisplatin nephrotoxicity include the reduction of renal blood flow, as well as tubular epithelial cell toxicity. The objective of this study was to investigate the influence of lower blood pressure and decreased food intake on the incidence of cisplatin nephrotoxicity. METHODS: We conducted a retrospective cohort study at a university hospital between 2011 and 2012. We identified hospitalized adult patients with head and neck cancer, esophageal cancer, or gastric cancer, who received intravenous cisplatin administration...
February 20, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28218905/phosphorylation-mediated-activation-of-ldha-promotes-cancer-cell-invasion-and-tumour-metastasis
#6
L Jin, J Chun, C Pan, G N Alesi, D Li, K R Magliocca, Y Kang, Z G Chen, D M Shin, F R Khuri, J Fan, S Kang
Metastases remain the major cause of death from cancer. Recent molecular advances have highlighted the importance of metabolic alterations in cancer cells, including the Warburg effect that describes an increased glycolysis in cancer cells. However, how this altered metabolism contributes to tumour metastasis remains elusive. Here, we report that phosphorylation-induced activation of lactate dehydrogenase A (LDHA), an enzyme that catalyses the interconversion of pyruvate and lactate, promotes cancer cell invasion, anoikis resistance and tumour metastasis...
February 20, 2017: Oncogene
https://www.readbyqxmd.com/read/28217020/correlation-of-positron-emission-tomography-computed-tomography-scan-with-smoking-tumor-size-stage-and-differentiation-in-head-and-neck-cancer-patients
#7
Jordan L Pleitz, Partha Sinha, Emily V Dressler, Rony K Aouad
The goal of this study was to identify associations between positron emission tomography/computed tomography (PET/CT) maximum standardized uptake value (SUVmax) in patients presenting with head and neck squamous cell carcinoma (SCC) with tumor site, size, histologic differentiation, smoking, and diabetes. Charts of patients with oropharyngeal and laryngeal SCC who underwent (18)F-fluorodeoxyglucose PET/CT scans were reviewed between May 2007 and August 2013. Statistical analyses included modeling log-transformed SUVmax values by tumor site, size, histologic differentiation, smoking status, and diabetes using unadjusted linear regressions...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28216066/the-potential-effect-of-oral-microbiota-in-the-prediction-of-mucositis-during-radiotherapy-for-nasopharyngeal-carcinoma
#8
Xiao-Xia Zhu, Xiao-Jun Yang, Yi-Lan Chao, Hui-Min Zheng, Hua-Fang Sheng, Hai-Yue Liu, Yan He, Hong-Wei Zhou
BACKGROUND: Oral mucositis is probably the most debilitating complication that can arise in treating a patient with head and neck cancer. Little is known about the impacts of oral microbiota on the initiation and progression of mucositis. METHODS: Based on 16S rRNA gene sequencing, dynamic changes in oral bacterial profile as well as correlations between the severity of mucositis and bacterial shifts during radiotherapy were investigated. FINDINGS: Our results revealed that bacterial community structure altered progressively during radiation therapy, in parallel with a marked increase in the relative abundance of some Gram-negative bacteria...
February 7, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28215050/racial-disparities-in-preventable-risk-factors-for-head-and-neck-cancer
#9
Sunshine Dwojak, Neil Bhattacharyya
OBJECTIVES/HYPOTHESIS: To demonstrate racial differences in preventable risk behaviors/practices that contribute to head and neck cancer (HNCA). STUDY DESIGN: Cross-sectional analysis of large national risk factor survey. METHODS: The Behavioral Risk Factor Surveillance System for 2013 was analyzed. Demographic data were extracted, including age, sex, and race. Social habits considered risk factors for HNCA were also extracted, including alcohol consumption, smoking, and human papillomavirus (HPV) vaccination status...
February 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28214178/validation-of-the-university-of-washington-quality-of-life-chinese-version-uwqol-c-for-head-and-neck-cancer-patients-in-taiwan
#10
Yun-Hsiang Lee, Yeur-Hur Lai, Bevan Yueh, Pen-Yuan Chu, Yen-Ju Chen, Shu-Ching Chen, Cheng-Ping Wang
BACKGROUND/PURPOSE: The purposes of this three-phase study were to: (1) translate and evaluate the burden, content, and face validity of the Chinese version of the University of Washington Quality of Life Scale, version 4 (UWQOL-v4-C); and (2) examine the psychometric properties of the UWQOL-v4-C in oral cancer and laryngeal cancer patients in Taiwan. METHODS: This instrument translation and validation study was part of a major research project. The first phase of this study developed and validated the content of the UWQOL-v4-C...
February 14, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28210977/genetic-characterization-of-adenoid-cystic-carcinoma-of-the-minor-salivary-glands-a-potential-familial-occurrence-in-first-degree-relatives
#11
Hani Ibrahim Channir, Thomas van Overeem Hansen, Simon Andreasen, Christina Westmose Yde, Katalin Kiss, Birgitte Wittenborg Charabi
Adenoid cystic carcinoma (AdCC) is a malignant salivary gland tumor. To date, no cases of AdCC in first-degree relatives have been reported in the literature. We present a 50-year-old female (Case 1) and this patients' father (Case 2), both of whom were diagnosed with AdCC of the minor salivary glands. Histology of Case 1 demonstrated a tubulocribriform AdCC whereas Case 2 primarily was an AdCC of solid type. Both cases harbored the MYB-NFIB gene fusion as demonstrated by FISH and RNA-sequencing. After filtering and selection of putative deleterious variants, whole exome sequencing identified 18 germline variants in common between Case 1 and Case 2...
February 16, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28209070/assessment-of-quality-of-life-in-phase-iii-trials-of-radiotherapy-in-localized-or-locally-advanced-head-and-neck-cancer-over-the-past-17-years
#12
Gustavo Nader Marta, Everardo D Saad
BACKGROUND: We investigated the extent to which health-related quality of life (HRQOL) parameters have been used as endpoints in recent phase III trials on radiotherapy for head and neck cancer, as well as the frequency and correlates of significant HRQOL gains. METHODS: Using the medical subject headings "head and neck neoplasms" and "radiotherapy", we searched PubMed for the main paper reporting phase III trials published between 1/1999 and 12/2015 in 16 leading journals...
January 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28206871/swallowing-therapy-and-progressive-resistance-training-in-head-and-neck-cancer-patients-undergoing-radiotherapy-treatment-randomized-control-trial-protocol-and-preliminary-data
#13
Sara F Hajdú, Irene Wessel, Christoffer Johansen, Claus A Kristensen, Zahra T Kadkhoda, Christina C Plaschke, Susanne O Dalton
BACKGROUND: Head and neck cancer (HNC) patients are often challenged by treatment induced dysphagia and trismus. Traditionally, rehabilitation is initiated when loss of function has already occurred. There is increasing evidence that it is of benefit to patients to initiate an early rehabilitation process before and during treatment. HNC patients have a unique set of functional challenges such as pre- and post-treatment dysphagia, pain and weight loss. The aim of the trial is to investigate the effects of swallowing and mouth-opening exercises combined with progressive resistance training (PRT) during radiotherapy...
February 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28205306/multi-site-quality-and-variability-analysis-of-3d-fdg-pet-segmentations-based-on-phantom-and-clinical-image-data
#14
Reinhard R Beichel, Brian J Smith, Christian Bauer, Ethan J Ulrich, Payam Ahmadvand, Mikalai M Budzevich, Robert J Gillies, Dmitry Goldgof, Milan Grkovski, Ghassan Hamarneh, Qiao Huang, Paul E Kinahan, Charles M Laymon, James M Mountz, John P Muzi, Mark Muzi, Sadek Nehmeh, Matthew J Oborski, Yongqiang Tan, Binsheng Zhao, John J Sunderland, John M Buatti
PURPOSE: Radiomics utilizes a large number of image-derived features for quantifying tumor characteristics that can in turn be correlated with response and prognosis. Unfortunately, extraction and analysis of such image-based features is subject to measurement variability and bias. The challenge for radiomics is particularly acute in Positron Emission Tomography (PET) where limited resolution, a high noise component related to the limited stochastic nature of the raw data, and the wide variety of reconstruction options confound quantitative feature metrics...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28205149/making-implicit-assumptions-explicit-in-the-costing-of-informal-care-the-case-of-head-and-neck-cancer-in-ireland
#15
Paul Hanly, Rebecca Maguire, Myles Balfe, Eleanor O'Sullivan, Linda Sharp
BACKGROUND: From a health service perspective, informal care is often viewed as a potentially cost-effective way of transferring costs out of the formal healthcare sector. However, informal care is not a free resource. OBJECTIVE: Our objective was to assess the impact of alternative valuation methods and key assumptions on the cost of informal care. METHODS: Informal carers who assisted in the care of a head and neck cancer survivor for at least 1 year were sent a postal questionnaire during January-June 2014 requesting information on time spent on caring tasks in the month prior to the survey...
February 15, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28204992/the-life-experience-of-nutrition-impact-symptoms-during-treatment-for-head-and-neck-cancer-patients-a-systematic-review-and-meta-synthesis
#16
REVIEW
Valentina Bressan, Annamaria Bagnasco, Giuseppe Aleo, Gianluca Catania, Milko P Zanini, Fiona Timmins, Loredana Sasso
PURPOSE: In the literature, there is limited research about the changed meaning of food, the eating and the eating experience during treatment in patients with head and neck cancer. This systematic review includes findings from a qualitative research synthesis to gain a deeper understanding of the influence and experiences of dysphagia, dysgeusia, oral mucositis and xerostomia in head and neck cancer patients (HNC) and suggests recommendations for care practice. METHOD: A systematic review and meta-synthesis techniques were adopted to identify, appraise and synthesize the relevant literature regarding the experience of nutritional symptoms of HNC patients conducted according to the PRISMA guidelines...
February 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28204852/-brain-metastasis-versus-radiation-necrosis-after-head-and-neck-cancer-brain-lesion-after-head-and-neck-cancer
#17
B Kofler, J Kerschbaumer, V H Schartinger, A Posch, E R Gizewski, G Widmann
No abstract text is available yet for this article.
February 15, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28198401/enrichment-of-circulating-head-and-neck-tumour-cells-using-spiral-microfluidic-technology
#18
Arutha Kulasinghe, Thao Huynh Phuoc Tran, Tony Blick, Ken O'Byrne, Erik W Thompson, Majid E Warkiani, Colleen Nelson, Liz Kenny, Chamindie Punyadeera
Whilst locoregional control of head and neck cancers (HNCs) has improved over the last four decades, long-term survival has remained largely unchanged. A possible reason for this is that the rate of distant metastasis has not changed. Such disseminated disease is reflected in measurable levels of cancer cells in the blood of HNC patients, referred to as circulating tumour cells (CTCs). Numerous marker-independent techniques have been developed for CTC isolation and detection. Recently, microfluidics-based platforms have come to the fore to avoid molecular bias...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197773/change-in-tongue-pressure-in-patients-with-head-and-neck-cancer-after-surgical-resection
#19
Yoko Hasegawa, Kazuma Sugahara, Tatsuyuki Fukuoka, Shota Saito, Ayumi Sakuramoto, Nobuhide Horii, Saori Sano, Kana Hasegawa, Yuta Nakao, Tomoki Nanto, Kanenori Kadoi, Kuniyasu Moridera, Kazuma Noguchi, Kazuhisa Domen, Hiromitsu Kishimoto
Tongue pressure is reportedly associated with dysphagia. This study investigated relationships among characteristics of head and neck cancer, tongue pressure and dysphagia screening tests performed in patients with head and neck cancer during the acute phase after surgical resection. Fifty-seven patients (36 men, 21 women; age range 26-95 years) underwent surgical resection and dysphagia screening tests (Repetitive Saliva Swallowing Test, Water Swallowing Test, Modified Water Swallowing Test and Food Test) and pre- and postoperative measurement of tongue pressure at 5 time points (preoperatively, and 1-2 weeks and 1, 2, and 3 months postoperatively)...
February 14, 2017: Odontology
https://www.readbyqxmd.com/read/28197666/elevated-basal-antibody-dependent-cell-mediated-cytotoxicity-adcc-and-high-epidermal-growth-factor-receptor-egfr-expression-predict-favourable-outcome-in-patients-with-locally-advanced-head-and-neck-cancer-treated-with-cetuximab-and-radiotherapy
#20
Laura Lattanzio, Nerina Denaro, Daniela Vivenza, Chiara Varamo, Giuliana Strola, Mirella Fortunato, Emmanuel Chamorey, Alberto Comino, Martino Monteverde, Cristiana Lo Nigro, Gerard Milano, Marco Merlano
BACKGROUND: Antibody-dependent cell-mediated cytotoxicity (ADCC) may contribute to the antitumor activity of cetuximab. However, the extent of this contribution is unclear. In this study, we investigated the impact of baseline ADCC on the outcome of patients with locally advanced squamous cell carcinoma treated with cetuximab and radiotherapy. METHODS: We determined baseline ADCC in 28 patients treated with cetuximab and radiotherapy and in 15 patients treated with chemoradiation...
February 14, 2017: Cancer Immunology, Immunotherapy: CII
keyword
keyword
100074
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"