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https://www.readbyqxmd.com/read/29928961/cisd2-inhibition-overcomes-resistance-to-sulfasalazine-induced-ferroptotic-cell-death-in-head-and-neck-cancer
#1
Eun Hye Kim, Daiha Shin, Jaewang Lee, Ah Ra Jung, Jong-Lyel Roh
Sulfasalazine has been repurposed to induce ferroptotic cancer cell death via inhibition of xc - -cystine/glutamate antiporter (xCT). However, cancer cells are capable of developing mechanisms to evade cell death. Therefore, we sought to determine the molecular mechanisms underlying resistance to sulfasalazine-induced ferroptosis in head and neck cancer (HNC). The effects of sulfasalazine and pioglitazone were tested in various HNC cell lines. The effects of these drugs and inhibition and overexpression of CISD2 gene were determined by evaluating viability, cell death, lipid ROS production, mitochondrial iron, and mouse tumor xenograft models...
June 18, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29927717/drug-targeting-and-biomarkers-in-head-and-neck-cancers-insights-from-systems-biology-analyses
#2
Tania Islam, Rezanur Rahman, Esra Gov, Beste Turanli, Gizem Gulfidan, Anwarul Haque, Kazım Yalçın Arga, Nurul Haque Mollah
The head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in the world, but robust biomarkers and diagnostics are still not available. This study provides in-depth insights from systems biology analyses to identify molecular biomarker signatures to inform systematic drug targeting in HNSCC. Gene expression profiles from tumors and normal tissues of 22 patients with histological confirmation of nonmetastatic HNSCC were subjected to integrative analyses with genome-scale biomolecular networks (i...
June 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29927013/depressive-symptoms-in-relation-to-overall-survival-in-people-with-head-and-neck-cancer-a-longitudinal-cohort-study
#3
Femke Jansen, Irma M Verdonck-de Leeuw, Pim Cuijpers, C René Leemans, Tim Waterboer, Michael Pawlita, Chris Penfold, Steven J Thomas, Andrea Waylen, Andrew R Ness
OBJECTIVE: To investigated the relation between pre-treatment depressive symptoms (DS) and the course of DS during the first year after cancer diagnosis, and overall survival among people with head and neck cancer (HNC). METHODS: Data from the Head and Neck 5000 prospective clinical cohort study were used. DS were measured using the Hospital Anxiety and Depression Scale (HADS) pre-treatment, at 4 and 12 months follow-up. Also socio-demographic, clinical, lifestyle and mortality data were collected...
June 21, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29926755/mn-porphyrin-based-redox-active-drugs-differential-effects-as-cancer-therapeutics-and-protectors-of-normal-tissue-against-oxidative-injury
#4
Ines Batinic-Haberle, Artak Tovmasyan, Ivan Spasojevic
SIGNIFICANCE: After ~3 decades of research, two Mn(III) porphyrins(MnPs), MnTE-2-PyP5+ (BMX-010,AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001) have progressed to 5 clinical trials. In parallel, another similarly potent metal-based superoxide dismutase (SOD) mimic - Mn(II)pentaaza macrocycle, GC4419 - has been tested in clinical trial on application, identical to that one of MnTnBuOE-2-PyP5+ - radioprotection of normal tissue in Head and Neck cancer patients. This clearly indicates that Mn complexes, that target cellular redox environment, have reached sufficient maturity for clinical applications...
June 21, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29925431/inhibition-of-wee1-kinase-and-cell-cycle-checkpoint-activation-sensitizes-head-and-neck-cancers-to-natural-killer-cell-therapies
#5
Jay Friedman, Megan Morisada, Lillian Sun, Ellen C Moore, Michelle Padget, James W Hodge, Jeffrey Schlom, Sofia R Gameiro, Clint T Allen
BACKGROUND: Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes. NK cells and T-lymphocytes mediate early killing of targets through a common granzyme B-dependent mechanism. Tumor cell resistance to granzyme B and how this alters NK cell killing is not clearly defined. METHODS: Tumor cell sensitivity to cultured murine KIL and human high affinity NK (haNK) cells in the presence or absence of AZD1775, a small molecule inhibitor of WEE1 kinase, was assessed via real time impedance analysis...
June 21, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29925404/combating-head-and-neck-cancer-metastases-by-targeting-src-using-multifunctional-nanoparticle-based-saracatinib
#6
Liwei Lang, Chloe Shay, Yuanping Xiong, Parth Thakkar, Ron Chemmalakuzhy, Xuli Wang, Yong Teng
BACKGROUND: Inhibition of metastasis of head and neck squamous cell carcinoma (HNSCC) is one of the most important challenges in cancer treatment. Src, a non-receptor tyrosine kinase, has been implicated as a key promoter in tumor progression and metastasis of HNSCC. However, Src therapy for HNSCC is limited by lack of efficient in vivo delivery and underlying mechanisms remain elusive. METHODS: Src knockdown cells were achieved by lentiviral-mediated interference...
June 20, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29924079/a-systematic-review-and-meta-analysis-on-outcomes-and-complications-of-percutaneous-endoscopic-versus-radiologic-gastrostomy-for-enteral-feeding
#7
Denise Strijbos, Daniel Keszthelyi, Roel M M Bogie, Lennard P L Gilissen, Martin Lacko, Janneke G J Hoeijmakers, Christiaan van der Leij, Rogier de Ridder, Michiel W de Haan, Ad A M Masclee
BACKGROUND: The optimal technique for long-term enteral feeding has not yet been established. Both percutaneous endoscopic gastrostomy (PEG) and percutaneous radiologic gastrostomy (PRG) are widely used. Aim was to extensively review outcomes of PEG and PRG. MATERIALS AND METHODS: A systematic review using Medline, Embase, and Cochrane was performed, using standardized tools for assessing bias. Main outcomes were infectious and tube-related complications, procedure related and 30-day mortality...
June 19, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29922848/establishing-a-multidisciplinary-head-and-neck-clinical-pathway-an-implementation-evaluation-and-audit-of-dysphagia-related-services-and-outcomes
#8
Barbara Pisano Messing, Elizabeth C Ward, Cathy Lazarus, Keri Ryniak, Melissa Kim, Jessica Silinonte, Dorothy Gold, Carol B Thompson, Karen T Pitman, Ray Blanco, Ryan Sobel, Karen Harrer, Karen Ulmer, Geoffrey Neuner, Kruti Patel, Mei Tang, Gregory Lee
Head and neck cancer (HNC) guidelines recommend regular multidisciplinary team (MDT) monitoring and early intervention to optimize dysphagia outcomes; however, many factors affect the ability to achieve these goals. The aims of this study were to explore the barriers/facilitators to establishing and sustaining a MDT HNC care pathway and to examine the dysphagia-related speech-language pathology (SLP) and dietetic components of the pathway. Using the Consolidated Framework for Implementation Research (CFIR), a mixed methods study design was used to evaluate an established MDT HNC pathway...
June 19, 2018: Dysphagia
https://www.readbyqxmd.com/read/29921694/attenuated-traf3-fosters-alternative-activation-of-nf-%C3%AE%C2%BAb-and-reduced-expression-of-anti-viral-interferon-tp53-and-rb-to-promote-hpv-positive-head-and-neck-cancers
#9
Jialing Zhang, Tony Chen, Xinping Yang, Hui Cheng, Stephan S Späth, Paul E Clavijo, Jianhong Chen, Christopher Silvin, Natalia Issaeva, Xiulan Su, Wendell G Yarbrough, Christina M Annunziata, Zhong Chen, Carter Van Waes
Human papilloma viruses (HPV) are linked to an epidemic increase in oropharyngeal head and neck squamous cell carcinomas (HNSCC), which display viral inactivation of tumor suppressors TP53 and RB1 and rapid regional spread. However, the role of genomic alterations in enabling modulation of pathways that promote the aggressive phenotype of these cancers is unclear. Recently, a subset of HPV+ HNSCC has been shown to harbor novel genetic defects or decreased expression of TNF-receptor-associated-factor-3 (TRAF3)...
June 19, 2018: Cancer Research
https://www.readbyqxmd.com/read/29917252/comparison-of-complications-between-peripheral-arm-ports-and-central-chest-ports-a-meta-analysis
#10
REVIEW
Shanshan Wu, Wanjiao Li, Qiongxiao Zhang, Shuting Li, Lizi Wang
AIM: To compare peripheral arm ports versus central chest ports in complication rates. BACKGROUND: Late complications of arm ports versus chest ports, including catheter-related infection, venous thrombosis and catheter obstruction, remain controversial. DESIGN: A meta-analysis conducted following the Cochrane handbook. DATA SOURCES: Studies published between 1950 - August 2017 were searched through Pubmed, Embase, Web of science and Cochrane library...
June 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29914893/clinical-relevance-and-suppressive-capacity-of-human-mdsc-subsets
#11
Stephan Lang, Kirsten Bruderek, Cordelia Kaspar, Benedikt Höing, Oliver Kanaan, Nina Dominas, Timon Hussain, Freya Droege, Christian Peter Eyth, Boris Hadaschik, Sven Brandau
PURPOSE: Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of pathologically expanded myeloid cells with immunosuppressive activity. In human disease three major MDSC subpopulations can be defined as monocytic M-MDSC, granulocytic PMN-MDSC and early stage e-MDSC, which lack myeloid lineage markers of the former two subsets. It was the purpose of this study to determine and compare the immunosuppressive capacity and clinical relevance of each of these subsets in patients with solid cancer...
June 18, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29914577/clinical-trials-for-treating-recurrent-head-and-neck-cancer-with-boron-neutron-capture-therapy-using-the-tsing-hua-open-pool-reactor
#12
REVIEW
Ling-Wei Wang, Yen-Wan Hsueh Liu, Fong-In Chou, Shiang-Huei Jiang
Head and neck (HN) cancer is an endemic disease in Taiwan, China. Locally recurrent HN cancer after full-dose irradiation poses a therapeutic challenge, and boron neutron capture therapy (BNCT) may be a solution that could provide durable local control with tolerable toxicity. The Tsing-Hua Open Pool Reactor (THOR) at National Tsing-Hua University in Hsin-Chu, provides a high-quality epithermal neutron source for basic and clinical BNCT research. Our first clinical trial, entitled "A phase I/II trial of boron neutron capture therapy for recurrent head and neck cancer at THOR", was carried out between 2010 and 2013...
June 19, 2018: Cancer communications
https://www.readbyqxmd.com/read/29914057/human-papilloma-virus-and-autophagy
#13
REVIEW
Domenico Mattoscio, Alessandro Medda, Susanna Chiocca
Human papilloma viruses (HPVs) are a group of double-stranded DNA viruses known to be the primary cause of cervical cancer. In addition, evidence has now established their role in non-melanoma skin cancers, head and neck cancer (HNC), and the development of other anogenital malignancies. The prevalence of HPV-related HNC, in particular oropharyngeal cancers, is rapidly increasing, foreseeing that HPV-positive oropharyngeal cancers will outnumber uterine cervical cancers in the next 15⁻20 years. Therefore, despite the successful advent of vaccines originally licensed for cervical cancer prevention, HPV burden is still very high, and a better understanding of HPV biology is urgently needed...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29913945/prevention-and-treatment-of-trismus-in-head-and-neck-cancer-a-case-report-and-a-systematic-review-of-the-literature
#14
Piotr Wranicz, Bente Brokstad Herlofson, Jan F Evensen, Ulf E Kongsgaard
Introduction Trismus, or limited mouth opening, is a well-known complication of head and neck cancer and its treatment. It may be caused by tumour infiltration into the masticatory muscles or by treatment like surgery and radiotherapy. A limited mouth opening may have a negative effect on nutrition, phonation, dental hygiene and treatment, and quality of life. The severity of this complication depends on the location of the tumour, the type of reconstruction, the total radiation dose, fractionation, and treatment techniques...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913059/quality-of-life-of-head-and-neck-cancer-patients-in-urban-and-regional-areas-an-australian-perspective
#15
Kelsey A Pateman, Nicole L Cockburn, Martin D Batstone, Pauline J Ford
OBJECTIVE: Head and neck cancer treatment affects quality of life. There are differences in quality of life outcomes and perceived supportive care needs between cancer patients living in metropolitan and regional-remote areas. This study investigated quality of life over the first 6 months following head and neck cancer diagnosis and observed differences in quality of life by geographical location. DESIGN: Prospective observational study. SETTING: Tertiary hospital in Brisbane, Australia...
June 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29910699/dynamic-contrast-enhanced-magnetic-resonance-imaging-for-differentiating-between-primary-tumor-metastatic-node-and-normal-tissue-in-head-and-neck-cancer
#16
Liangliang Chen, Yufeng Ye, Hanwei Chen, Shihui Chen, Jinzhao Jiang, Guo Dan, Bingsheng Huang
OBJECTIVE: To study the difference of the Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) parameters among the primary tumor, metastatic node and peripheral normal tissue of head and neck cancer. MATERIALS AND METHODS: Consecutive newly-diagnosed head and neck cancer patients with nodal metastasis between December 2010 and July 2013 were recruited, and 25 patients (8 females; 24~63,mean 43±11 years old) were enrolled. DCE-MRI was performed in the primary tumor region including the regional lymph nodes on a 3...
June 2018: Current Medical Imaging Reviews
https://www.readbyqxmd.com/read/29909889/gene-signatures-and-expression-of-mirnas-associated-with-efficacy-of-panitumumab-in-a-head-and-neck-cancer-phase-ii-trial
#17
Marco Siano, Vittoria Espeli, Nicolas Mach, Paolo Bossi, Lisa Licitra, Michele Ghielmini, Milo Frattini, Silvana Canevari, Loris De Cecco
OBJECTIVE: Platinum-based chemotherapy plus the anti-EGFR monoclonal antibody (mAb) cetuximab is used to treat recurrent/metastatic (RM) head-neck squamous cell carcinoma (HNSCC). Recently, we defined Cluster3 gene-expression signature as a potential predictor of favorable progression-free survival (PFS) in cetuximab-treated RM-HNSCC patients and predictor of partial metabolic FDG-PET response in an afatinib window-of-opportunity trial. Another anti-EGFR-mAb (panitumumab) was used as the treatment agent in RM-HNSCC patients in the phase II PANI01trial...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909887/smoking-impact-on-hpv-driven-head-and-neck-cancer-s-oncological-outcomes
#18
Haitham Mirghani, Charlotte Leroy, Younes Chekourry, Odile Casiraghi, Anne Aupérin, Yungan Tao, France Nguyen, Even Caroline, Ingrid Breuskin, Antoine Moya Plana, Dana Hartl, François Janot, Stéphane Temam, Philippe Gorphe, Pierre Blanchard
INTRODUCTION: HPV-driven oropharyngeal cancer (OPC) patients have a better prognosis than their HPV-negative counterparts but several studies have suggested that among HPV-positive patients those with a smoking history had worse oncological outcomes. The aim of our study is to characterize the interplay between tobacco consumption, patient and disease characteristics, and disease control. MATERIALS AND METHODS: All patients diagnosed with HPV-driven OPC and treated with curative intent between 2007 and 2009 and 2011-2016 at Gustave Roussy cancer center were included (n = 282)...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909885/an-assessment-of-patient-burdens-from-head-and-neck-cancer-survivorship-care
#19
Sean T Massa, Rebecca L Rohde, Carole Mckinstry, Malia Gresham, Nosayaba Osazuwa-Peters, Gregory M Ward, Ronald J Walker
OBJECTIVES: To assess head and neck cancer (HNC) patients' perspectives on the value and burdens of routine cancer follow-up care. MATERIALS AND METHODS: Data was obtained from HNC patients (n = 100) at an urban, tertiary head and neck cancer clinic. A novel 15-question survey tool evaluated the logistic, financial, and psychosocial burdens associated with clinic visits. The clinical characteristics and survey responses of demographic groups were analyzed with comparative statistics...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29908705/high-levels-of-socioeconomic-deprivation-do-not-inhibit-patients-communication-of-concerns-in-head-and-neck-cancer-review-clinics
#20
S Allen, R Harris, S L Brown, G Humphris, Y Zhou, S N Rogers
To examine associations between socioeconomic status and the extent to which patients with cancer of the head and neck expressed concerns to surgeons during routine follow-up clinics, we analysed audio recordings of 110 consultations with one consultant. We used the Verona Coding Definitions of Emotional Sequences (VRCoDES) to measure communication between the doctor and the patient, and grouped the English indices of multiple deprivation (IMD) 2015 scores into deciles to compare the VRCoDES with socioeconomic status...
June 13, 2018: British Journal of Oral & Maxillofacial Surgery
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