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https://www.readbyqxmd.com/read/29159957/evaluating-performance-of-a-user-trained-mr-lung-tumor-autocontouring-algorithm-in-the-context-of-intra-and-inter-observer-variations
#1
Eugene Yip, Jihyun Yun, Zsolt Gabos, Sarah Baker, Don Yee, Keith Wachowicz, Satyapal Rathee, B Gino Fallone
PURPOSE: Real-time tracking of lung tumors using magnetic resonance imaging (MRI) has been proposed as a potential strategy to mitigate the ill-effects of breathing motion in radiation therapy. Several autocontouring methods have been evaluated against a "gold standard" of a single human expert user. However, contours drawn by experts have inherent intra- and inter-observer variations. In this study, we aim to evaluate our user-trained autocontouring algorithm with manually drawn contours from multiple expert users, and to contextualize the accuracy of these autocontours within intra- and inter- observer variations...
November 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/29152838/commissioning-of-the-world-s-first-compact-pencil-beam-scanning-proton-therapy-system
#2
Rajesh Pidikiti, Bijal C Patel, Matthew R Maynard, Joseph P Dugas, Joseph Syh, Narayan Sahoo, Hsinshun Terry Wu, Lane R Rosen
This paper summarizes clinical commissioning of the world's first commercial, clinically utilized installation of a compact, image-guided, pencil-beam scanning, intensity-modulated proton therapy system, the IBA Proteus(®) ONE, at the Willis-Knighton Cancer Center (WKCC) in Shreveport, LA. The Proteus(®) ONE is a single-room, compact-gantry system employing a cyclotron-generated proton beam with image guidance via cone-beam CT as well as stereoscopic orthogonal and oblique planar kV imaging. Coupling 220° of gantry rotation with a 6D robotic couch capable of in plane patient rotations of over 180° degrees allows for 360° of treatment access...
November 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29150313/safety-practices-perceptions-and-behaviors-in-radiation-oncology-a-national-survey-of-radiation-therapists
#3
Kristina Demas Woodhouse, David Hashemi, Kathryn Betcher, Abigail Doucette, Allison Weaver, Brian Monzon, Seth A Rosenthal, Neha Vapiwala
PURPOSE: Radiation therapy is complex and demands high vigilance and precise coordination. Radiation therapists (RTTs) directly deliver radiation and are often the first to discover an error. Yet, few studies have examined the practices of RTTs regarding patient safety. We conducted a national survey to explore the perspectives of RTTs related to quality and safety. METHODS AND MATERIALS: In 2016, an electronic survey was sent to a random sample of 1500 RTTs in the United States...
June 15, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29150160/medical-physics-in-radiation-oncology-new-challenges-needs-and-roles
#4
EDITORIAL
Dietmar Georg, David Thwaites
No abstract text is available yet for this article.
November 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29145591/asia-consensus-statement-on-nccn-clinical-practice-guideline-for-bladder-cancer
#5
Hiroyuki Nishiyama
The Asia Consensus Statement (ACS) on the NCCN Guideline (NCCN-ACS) for treatment of bladder cancer version 1.2016 is designed to provide documentation of modifications of the 'parent' NCCN Guideline: Bladder Cancer (Version 2.2015). When considering ethnic differences or differences in health regulatory environments between Western and Asian countries, a process of adaptation to match the circumstances is helpful for utilizing the guidelines. The NCCN-ACS for bladder cancer consist of 11 ACSs, focused on diagnosis, imaging, surgical treatment, adjuvant intravesical chemotherapy or immunotherapy, periopererative (neodjuvant or adjuvant) chemotherapy and radiation oncology including bladder preservation...
November 14, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29139040/recommendations-for-the-follow-up-care-of-female-breast-cancer-survivors-a-guideline-of-the-spanish-society-of-medical-oncology-seom-spanish-society-of-general-medicine-semergen-spanish-society-for-family-and-community-medicine-semfyc-spanish-society-for-general
#6
A Barnadas, M Algara, O Cordoba, A Casas, M Gonzalez, M Marzo, A Montero, M Muñoz, A Ruiz, F Santolaya, T Fernandez
The increased incidence and decreased mortality of breast cancer have produced an increased number of breast cancer survivors. The type of sequelae and comorbidities that these patients present call for a collaborative follow-up by hospital-based specialized care and primary care. In this document, we present a guideline drafted and agreed among scientific societies whose members care for breast cancer survivors. The purpose of this guideline is to achieve the shared and coordinated follow-up of these patients by specialized care and primary care professionals...
November 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29135537/status-and-perception-of-risk-management-in-radiation-therapy-survey-among-korean-medical-physicists
#7
Sohyun Ahn, Dong Oh Shin, Sang Hyoun Choi, Jihye Koo, Soon Sung Lee, Dong-Wook Park, Yoon-Jin Oh, Sohyun Park, Dong Wook Kim
This study was conducted as part of an endeavor to improve the risk management system of radiation therapy departments in the Republic of Korea. An online survey on the status and perception of Korea's medical physicists on risk management in radiation therapy was carried out. A total of 40 domestic radiation oncology departments participated. This survey is divided into three categories: (1) work environment; (2) risk management status; and (3) opinions on how to improve risk management. Based on the results of the survey, the conclusions that can be derived are (1) the majority of respondents have a high interest in the risk management of radiation therapy; (2) the lack of staffing is one cause of risk management difficulties; (3) a risk-related terminology and classification system at the national or professional association level are required; (4) each hospital should create a voluntary reporting system for the handling of incidents; (5) medical physicists should establish incident reporting, analysis and countermeasures; and (6) government should develop education and training programs...
November 10, 2017: Health Physics
https://www.readbyqxmd.com/read/29134728/recent-advances-in-veterinary-radiation-oncology
#8
EDITORIAL
Michael S Kent, Michelle M Turek, John Farrelly
No abstract text is available yet for this article.
November 13, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29126306/the-future-of-radiobiology
#9
David G Kirsch, Max Diehn, Aparna H Kesarwala, Amit Maity, Meredith A Morgan, Julie K Schwarz, Robert Bristow, Sandra Demaria, Iris Eke, Robert J Griffin, Daphne Haas-Kogan, Geoff S Higgins, Alec C Kimmelman, Randall J Kimple, Isabelle M Lombaert, Li Ma, Brian Marples, Frank Pajonk, Catherine C Park, Dörthe Schaue, Eric J Bernhard
Innovation and progress in radiation oncology depend on discovery and insights realized through research in radiation biology. Radiobiology research has led to fundamental scientific insights, from the discovery of stem/progenitor cells to the definition of signal transduction pathways activated by ionizing radiation that are now recognized as integral to the DNA damage response (DDR). Radiobiological discoveries are guiding clinical trials that test radiation therapy combined with inhibitors of the DDR kinases DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM), ataxia telangiectasia related (ATR), and immune or cell cycle checkpoint inhibitors...
November 3, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29120832/cost-benefit-analysis-of-establishing-and-operating-radiation-oncology-services-in-fiji
#10
Eunkyoung Kim, Yoon-Min Cho, Soonman Kwon, Kunhee Park
BACKGROUND: Rising demand for services of cancer patients has been recognised by the Government of Fiji as a national health priority. Increasing attention has been paid to the lack of service of radiation therapy or radiotherapy in Fiji. OBJECTIVE: This study aims to estimate and compare the costs and benefits of introducing radiation oncology services in Fiji from the societal perspective. METHODS: Time horizon for cost-benefit analysis (CBA) was 15 years from 2021 to 2035...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29115557/hypoxia-induces-differential-expression-patterns-of-osteopontin-and-cd44-in-colorectal-carcinoma
#11
Gisela Wohlleben, Konstantin Hauff, Martin Gasser, Ana Maria Waaga-Gasser, Tanja Grimmig, Michael Flentje, Bülent Polat
The plasma protein osteopontin (OPN) is considered to be a tumor biomarker, where elevated plasma levels are associated with poor prognosis. Additionally, OPN is expressed in the presence of tumor hypoxia, which is an adverse prognostic factor in radiation oncology. One of its receptors, the proposed tumor stem cell marker CD44, is also associated with aggressive tumors, shown for example in colon cancer. The expression of CD44 and its splice variants (particularly CD44v6) can be upregulated by OPN itself. In the present study, we aimed to investigate the influence of hypoxia on the expression of OPN and its binding partners CD44 and CD44v6 in colon carcinoma cell lines in vitro, using SW480, SW620, HT29 and HCT116 cells...
November 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29114610/initiative-to-reduce-bone-scans-for-low-risk-prostate-cancer-patients-a-quasi-experimental-before-and-after-study-in-a-veterans-affairs-hospital
#12
Eric Ojerholm, Keith N Van Arsdalen, Robert E Roses, Patrick Tripp
Purpose: Bone scans (BS) are a low-value test for asymptomatic men with low-risk prostate cancer. We performed a quality improvement intervention aimed at reducing BS for these patients. Methods and materials: The intervention was a presentation that leveraged the behavioral science concepts of social comparison and normative appeals. Participants were multidisciplinary stakeholders from the Radiation Oncology and Urology services at a Veterans Affairs hospital...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114591/tweet-for-the-cure-a-snapshot-of-twitter-usage-by-3%C3%A2-u-s-oncologic-professional-societies
#13
Sachin R Jhawar, Vinay Prabhu, Matthew S Katz, Sabin B Motwani
Purpose: Medical societies are incorporating Twitter to communicate with their members and connect with patients. This study compares the online presence of 3 major oncologic societies. Methods and materials: All available tweets in 2014 by the American Society for Radiation Oncology (ASTRO), American Society of Clinical Oncology (ASCO), and Society of Surgical Oncology (SSO) were collected. We analyzed whether posts were original content or retweets. The monthly tweet rate was followed to assess trends...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29114588/astro-s-advances-in-radiation-oncology-success-to-date-and-future-plans
#14
Robert C Miller, Sharad Goyal, Shearwood McClelland, Sabin Motwani, Charles Mayo, Tasneem Kaleem, Gregory Videtic, Kathleen Hintenlang
ASTRO's Advances in Radiation Oncology was launched as a new, peer-reviewed scientific journal in December 2015. More than 200 manuscripts have been submitted and 97 accepted for publication as of May 2017. As Advances enters its second year of publication, we have chosen to highlight subjects that will transform the way we practice radiation oncology in special issues or ongoing series: immunotherapy, biomedical analytics, and social media. A teaching case report contest for North American radiation oncology residents will be launched at American Society of Radiation Oncology 2017 to encourage participation in scientific publication by trainees early in their careers...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29110277/meta-analysis-of-local-invasive-breast-cancer-recurrence-after-electron-intraoperative-radiotherapy
#15
Jay K Harness, Kalatu Davies, Christina Via, Elizabeth Brooks, April Zambelli-Weiner, Chirag Shah, Frank Vicini
BACKGROUND: Electron intraoperative radiotherapy (IORT) can be used during breast conserving surgery to treat early-stage invasive breast cancer. Using data from current clinical and observational studies, this study aimed to assess the impact of single-fraction electron IORT on local recurrence rates. METHODS: Studies on single-fraction electron IORT during breast conserving surgery were identified through a search of PubMed and Google Scholar, as well as through secondary referencing...
November 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29110053/the-role-of-imaging-in-the-clinical-practice-of-radiation-oncology-for-pancreatic-cancer
#16
Eugene J Koay, William Hall, Peter C Park, Beth Erickson, Joseph M Herman
Advances in technology have enabled the delivery of high doses of radiation therapy for pancreatic ductal adenocarcinoma (PDAC) with low rates of toxicity. Although the role of radiation for pancreatic cancer continues to evolve, encouraging results with newer techniques indicate that radiation may benefit selected patient populations. Imaging has been central to the modern successes of radiation therapy for PDAC. Here, we review the role of diagnostic imaging, imaging-based planning, and image guidance in radiation oncology practice for PDAC...
November 6, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29106810/stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer-american-society-of-clinical-oncology-endorsement-of-the-american-society-for-radiation-oncology-evidence-based-guideline
#17
Bryan J Schneider, Megan E Daly, Erin B Kennedy, Mara B Antonoff, Stephen Broderick, Jill Feldman, Shruti Jolly, Bryan Meyers, Gaetano Rocco, Chad Rusthoven, Ben J Slotman, Daniel H Sterman, Brendon M Stiles
Purpose The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on treatment with stereotactic body radiotherapy (SBRT) for patients with early-stage non-small-cell lung cancer. ASCO has a policy and set of procedures for endorsing and/or adapting clinical practice guidelines that have been developed by other professional organizations. Methods The ASTRO Evidence-Based Guideline for Stereotactic Body Radiotherapy for Early-Stage Non-Small-Cell Lung Cancer was reviewed for developmental rigor by methodologists...
November 6, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29105051/tumour-bed-boost-radiotherapy-for-women-after-breast-conserving-surgery
#18
REVIEW
Isabelle Kindts, Annouschka Laenen, Tom Depuydt, Caroline Weltens
BACKGROUND: Breast-conserving therapy, involving breast-conserving surgery followed by whole-breast irradiation and optionally a boost to the tumour bed, is a standard therapeutic option for women with early-stage breast cancer. A boost to the tumour bed means that an extra dose of radiation is applied that covers the initial tumour site. The rationale for a boost of radiotherapy to the tumour bed is that (i) local recurrence occurs mostly at the site of the primary tumour because remaining microscopic tumour cells are most likely situated there; and (ii) radiation can eliminate these causative microscopic tumour cells...
November 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29104835/online-adaptive-radiation-therapy-implementation-of-a-new-process-of-care
#19
James Lamb, Minsong Cao, Amar Kishan, Nzhde Agazaryan, David H Thomas, Narek Shaverdian, Yingli Yang, Suzette Ray, Daniel A Low, Ann Raldow, Michael L Steinberg, Percy Lee
Onboard magnetic resonance imaging (MRI) guided radiotherapy is now clinically available in nine centers in the world. This technology has facilitated the clinical implementation of online adaptive radiotherapy (OART), or the ability to alter the daily treatment plan based on tumor and anatomical changes in real-time while the patient is on the treatment table. However, due to the time sensitive nature of OART, implementation in a large and busy clinic has many potential obstacles as well as patient-related safety considerations...
August 27, 2017: Curēus
https://www.readbyqxmd.com/read/29103854/variation-in-radiotherapy-referral-and-treatment-for-high-risk-pathological-features-after-radical-prostatectomy-results-from-a%C3%A2-population-based-study
#20
C J Jin, T P Hanna, E F Cook, Q Miao, M D Brundage
AIMS: Guidelines recommend the discussion of adjuvant radiotherapy post-prostatectomy for prostate cancer patients with high-risk pathology to consider all of their treatment options. We determine whether patterns of radiotherapy referral and treatment post-prostatectomy reflect guideline-based use in a contemporary prostatectomy cohort. MATERIALS AND METHODS: Electronic treatment records were linked to Ontario's cancer registry. Multivariable regression was used to evaluate clinical and health systems factors associated with referral and the use of adjuvant radiotherapy within 6 months post-prostatectomy...
November 2, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
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