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Gross Motor

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https://www.readbyqxmd.com/read/29036636/genetic-reduction-of-nrf2-exacerbates-cognitive-deficits-in-a-mouse-model-of-alzheimer-s-disease
#1
Caterina Branca, Eric Ferreira, Thuy-Vi Nguyen, Kristian Doyle, Antonella Caccamo, Salvatore Oddo
Aging is the major risk factor for several neurodegenerative diseases, including Alzheimer's disease (AD). However, the mechanisms by which aging contributes to neurodegeneration remain elusive. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcription factor that regulates expression of a vast number of genes by binding to the antioxidant response element. Nrf2 levels decrease as a function of age, and reduced Nrf2 levels have been reported in postmortem human brains and animal models of AD...
September 19, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29035576/inter-and-intrarater-reliabilities-of-the-test-of-gross-motor-development-third-edition-among-experienced-tgmd-2-raters
#2
Hyokju Maeng, E Kipling Webster, E Andrew Pitchford, Dale A Ulrich
The purpose of this study was to examine the inter- and intrarater reliabilities of the Test of Gross Motor Development-third edition (TGMD-3). The TGMD-3 was administered to 10 typically developing children. Five raters with experience using the Test of Gross Motor Development-second edition (TGMD-2) scored the digitally recorded performances and then rescored the same performances after a period of 2 weeks. Intraclass correlation (ICC) was used to examine both inter- and intrarater reliabilities of scores...
October 16, 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/29028557/understanding-the-association-between-stunting-and-child-development-in-low-and-middle-income-countries-next-steps-for-research-and-intervention
#3
REVIEW
Jessica M Perkins, Rockli Kim, Aditi Krishna, Mark McGovern, Victor M Aguayo, S V Subramanian
Stunting, caused by experiences of chronic nutritional deprivation, affects approximately 25% of children under age five globally (i.e., 156 million children). In this review, evidence of a relationship between stunting and child development in low- and middle-income countries is summarized, and issues for further research are discussed. We focus on studies that measured low height-for-age among children less than 5 years old as the exposure and gross/fine motor skills, psychosocial competencies, cognitive abilities, or schooling and learning milestones as the outcomes...
September 22, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29023517/developmental-delay-in-the-amazon-the-social-determinants-and-prevalence-among-rural-communities-in-peru
#4
Christopher Westgard, Yossef Alnasser
The consequences of poor child development are becoming increasingly recognized. Programs are being put in place around the world to improve child development by providing healthy and stimulating environments for children. However, these programs often have limited reach and little is known about the prevalence of developmental delay in under-developed communities. The current study set-out to better understand the prevalence of developmental delay in rural communities in the Amazon region of Peru. Also, it explores social determinants that are associated with any delay...
2017: PloS One
https://www.readbyqxmd.com/read/29020061/catching-up-children-with-developmental-coordination-disorder-compared-to-healthy-children-before-and-after-sensorimotor-therapy
#5
Mats Niklasson, Torsten Norlander, Irene Niklasson, Peder Rasmussen
The aims of the present study were to (a) compare healthy children in terms of sensorimotor maturity to untreated children diagnosed with developmental coordination disorder (DCD) and (b) compare healthy children to diagnosed children following completed treatment with sensorimotor therapy. Participants were 298 children, 196 boys and 102 girls, distributed into a Norm group of healthy children (n = 99) and a group of children diagnosed with DCD (n = 199) with a total mean age of 8.77 years (SD = 2.88). Participants in both groups were assessed on instruments aimed to detect sensorimotor deviations...
2017: PloS One
https://www.readbyqxmd.com/read/29016199/ability-based-balancing-using-the-gross-motor-function-measure-in-exergaming-for-youth-with-cerebral-palsy
#6
Alexander MacIntosh, Lauren Switzer, Susan Hwang, Adrian L Jessup Schneider, Daniel Clarke, T C Nicholas Graham, Darcy L Fehlings
OBJECTIVE: To test if the gross motor function measure (GMFM) could be used to improve game balancing allowing youth with cerebral palsy (CP) with different physical abilities to play a cycling-based exercise videogame together. Our secondary objective determined if exergaming with the GMFM Ability-Based algorithm was enjoyable. MATERIALS AND METHODS: Eight youth with CP, 8-14 years of age, GMFM scores between 25.2% and 87.4% (evenly distributed between Gross Motor Function Classification System levels II and III), competed against each other in head-to-head races, totaling 28 unique race dyads...
October 10, 2017: Games for Health
https://www.readbyqxmd.com/read/28990434/therapeutic-effect-evaluation-of-neuromuscular-electrical-stimulation-with-or-without-strengthening-exercise-on-spastic-cerebral-palsy
#7
Ya-Chao Qi, Xiao-Li Niu, Ya-Ran Gao, He-Bo Wang, Ming Hu, Li-Peng Dong, Ya-Zhou Li
The aims of this study were to investigate the effect of neuromuscular electrical stimulation (NMES) combined with strengthening exercise on movement in children with spastic cerebral palsy (CP). One hundred children with spastic CP were randomly divided into a treatment group (NMES and strengthening exercise, n = 50) and a control group (only NMES, n = 50). We compared the Comprehensive Spasticity Scale (CSS) score, Gross Motor Function Measure (GMFM) score, and walking speed before treatment and 6 weeks and 3 months after treatment between the 2 groups...
October 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28988795/exposure-to-elemental-composition-of-outdoor-pm2-5-at-birth-and-cognitive-and-psychomotor-function-in-childhood-in-four-european-birth-cohorts
#8
Małgorzata J Lubczyńska, Jordi Sunyer, Henning Tiemeier, Daniela Porta, Monika Kasper-Sonnenberg, Vincent W V Jaddoe, Xavier Basagaña, Albert Dalmau-Bueno, Francesco Forastiere, Jürgen Wittsiepe, Barbara Hoffmann, Mark Nieuwenhuijsen, Gerard Hoek, Kees de Hoogh, Bert Brunekreef, Mònica Guxens
BACKGROUND: Little is known about developmental neurotoxicity of particulate matter composition. We aimed to investigate associations between exposure to elemental composition of outdoor PM2.5 at birth and cognitive and psychomotor functions in childhood. METHODS: We analyzed data from 4 European population-based birth cohorts in the Netherlands, Germany, Italy and Spain, with recruitment in 2000-2006. Elemental composition of PM2.5 measurements were performed in each region in 2008-2011 and land use regression models were used to predict concentrations at participants' residential addresses at birth...
October 5, 2017: Environment International
https://www.readbyqxmd.com/read/28987971/best-seating-condition-in-children-with-spastic-cerebral-palsy-one-type-does-not-fit-all
#9
Mattana Angsupaisal, Linze-Jaap Dijkstra, Sacha la Bastide-van Gemert, Jessika F van Hoorn, Karine Burger, Carel G B Maathuis, Mijna Hadders-Algra
BACKGROUND: The effect of forward-tilting of the seat surface and foot-support in children with spastic cerebral palsy (CP) is debated. AIM: To assess the effect of forward-tilting of the seat surface and foot-support in children with CP on kinematic head stability and reaching. METHODS: Nineteen children functioning at Gross Motor Function Classification System levels I-III participated [range 6-12y; ten unilateral spastic CP (US-CP) and nine bilateral spastic CP (BS-CP)]...
October 5, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28986652/infant-development-and-pre-and-post-partum-depression-in-rural-south-african-hiv-infected-women
#10
Violeta J Rodriguez, Gladys Matseke, Ryan Cook, Seanna Bellinger, Stephen M Weiss, Maria L Alcaide, Karl Peltzer, Doyle Patton, Maria Lopez, Deborah L Jones
HIV-exposed infants born to depressed women may be at risk for adverse developmental outcomes. Half of HIV-infected women in rural South Africa (SA) may suffer from pregnancy-related depression. This pilot study examined the impact of depression in HIV-infected women in rural SA on infant development. Mother-infant dyads (N = 69) were recruited in rural SA. Demographics, HIV disclosure, depression, male involvement, and alcohol use at baseline (18.35 ± 5.47 weeks gestation) were assessed. Male involvement, depression, infant HIV serostatus and development were assessed 12 months postnatally...
October 6, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28980355/cortical-disconnection-of-the-ipsilesional-primary-motor-cortex-is-associated-with-gait-speed-and-upper-extremity-motor-impairment-in-chronic-left-hemispheric-stroke
#11
Denise M Peters, Julius Fridriksson, Jill C Stewart, Jessica D Richardson, Chris Rorden, Leonardo Bonilha, Addie Middleton, Ezequiel Gleichgerrcht, Stacy L Fritz
Advances in neuroimaging have enabled the mapping of white matter connections across the entire brain, allowing for a more thorough examination of the extent of white matter disconnection after stroke. To assess how cortical disconnection contributes to motor impairments, we examined the relationship between structural brain connectivity and upper and lower extremity motor function in individuals with chronic stroke. Forty-three participants [mean age: 59.7 (±11.2) years; time poststroke: 64.4 (±58.8) months] underwent clinical motor assessments and MRI scanning...
October 5, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28977332/concurrent-validity-of-the-brunet-l%C3%A3-zine-scale-with-the-bayley-scale-for-assessment-of-the-development-of-preterm-infants-up-to-two-years
#12
Fernanda Guimarães Campos Cardoso, Cibelle Kayenne Martins Roberto Formiga, Thailyne Bizinotto, Rogério Blasbalg Tessler, Francisco Rosa
OBJECTIVE: To verify the correlation between the areas evaluated by the Brunet-Lézine and the Bayley III scales of preterm infants up to two years. METHODS: The study included 88 children who were divided into 3 groups: Group 1 (1 month to 5 months and 29 days of corrected chronological ages - CCA) with 32 children; Group 2 (6 months to 11 months and 29 days of CCA) with 36 participants; and Group 3 (18 -23 months and 23 days of CCA) with 20 children. The concurrent validity of the Brunet-Lézine scale and the Bayley III scale was calculated using the Pearson correlation or its non-parametric version, the Spearman correlation...
April 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28969374/biallelic-mutations-in-the-homeodomain-of-nkx6-2-underlie-a-severe-hypomyelinating-leukodystrophy
#13
Imen Dorboz, Chiara Aiello, Cas Simons, Robert Thompson Stone, Marcello Niceta, Monique Elmaleh, Mohammad Abuawad, Diane Doummar, Alessandro Bruselles, Nicole I Wolf, Lorena Travaglini, Odile Boespflug-Tanguy, Marco Tartaglia, Adeline Vanderver, Diana Rodriguez, Enrico Bertini
Hypomyelinating leukodystrophies are genetically heterogeneous disorders with overlapping clinical and neuroimaging features reflecting variable abnormalities in myelin formation. We report on the identification of biallelic inactivating mutations in NKX6-2, a gene encoding a transcription factor regulating multiple developmental processes with a main role in oligodendrocyte differentiation and regulation of myelin-specific gene expression, as the cause underlying a previously unrecognized severe variant of hypomyelinating leukodystrophy...
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28967311/transpetrosal-approach-to-petro-clival-meningioma
#14
Turki Elarjani, Rakshith Shetty, Harminder Singh, Harley B da Silva, Laligam N Sekhar
A 38-year-old woman had a 3-week gradual onset of right-sided weakness in the upper and lower extremities. MRI showed a large left petro-clival meningioma encasing the basilar and left superior cerebellar artery and compressing the brainstem. A posterior transpetrosal approach, with a left temporal and retrosigmoid craniotomy and mastoidectomy, was performed. The tumor was removed in a gross-total resection with questionable remnants adherent to the brainstem. Intraoperative partial iatrogenic injury to the left oculomotor nerve was repaired with fibrin glue...
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28967231/congenital-anomalies-and-the-severity-of-impairments-for-cerebral-palsy
#15
Kjersti P Jystad, Kristin M Strand, Solveig Bjellmo, Stian Lydersen, Kari Klungsöyr, Magne Stoknes, Jon Skranes, Guro L Andersen, Torstein Vik
AIM: To study the prevalence of congenital anomalies among children with cerebral palsy (CP) born at term or late preterm, and if CP subtypes and clinical manifestations differ between children with and without congenital anomalies. METHOD: This was a cross-sectional study using data from the Cerebral Palsy Register of Norway and the Medical Birth Registry of Norway. All children with congenital CP born at and later than 34 weeks' gestation in Norway from 1999 to 2009 were included...
October 2, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28965494/the-impacts-of-maternal-iron-deficiency-and-being-overweight-during-pregnancy-on-neurodevelopment-of-the-offspring
#16
Staffan K Berglund, Francisco J Torres-Espínola, Luz García-Valdés, Mª Teresa Segura, Cristina Martínez-Zaldívar, Carmen Padilla, Ricardo Rueda, Miguel Pérez García, Harry J McArdle, Cristina Campoy
Both maternal Fe deficiency (ID) and being overweight or obese (Ow/Ob, BMI≥25 kg/m2) may negatively affect offspring brain development. However, the two risk factors correlate and their independent effects on infant neurodevelopment are unclear. PREOBE is a prospective observational study that included 331 pregnant Spanish women, of whom 166 had pre-gestational Ow/Ob. Fe status was analysed at 34 weeks and at delivery, and babies were assessed using Bayley III scales of neurodevelopment at 18 months. In confounder-adjusted analyses, maternal ID at 34 weeks was associated with lower composite motor scores at 18 months (mean 113·3 (sd 9·9) v...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28960836/bcl11a-frameshift-mutation-associated-with-dyspraxia-and-hypotonia-affecting-the-fine-gross-oral-and-speech-motor-systems
#17
Julie Soblet, Ivan Dimov, Clemens Graf von Kalckreuth, Julie Cano-Chervel, Simon Baijot, Karin Pelc, Martine Sottiaux, Catheline Vilain, Guillaume Smits, Nicolas Deconinck
We report the case of a 7-year-old male of Western European origin presenting with moderate intellectual disability, severe childhood apraxia of speech in the presence of oral and manual dyspraxia, and hypotonia across motor systems including the oral and speech motor systems. Exome sequencing revealed a de novo frameshift protein truncating mutation in the fourth exon of BCL11A, a gene recently demonstrated as being involved in cognition and language development. Making parallels with a previously described patient with a 200 kb 2p15p16...
September 27, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28954441/developmental-assessments-during-injury-research-is-enrollment-of-very-young-children-in-cr%C3%A3-ches-associated-with-better-scores
#18
Divya Nair, Olakunle Alonge, Jena Derakhshani Hamadani, Shumona Sharmin Salam, Irteja Islam, Adnan A Hyder
The Developmental Study is part of a larger intervention on "saving of lives from drowning (SoLiD)" where children were enrolled either into crèches (daycare centers) or playpens to prevent drowning in rural Bangladesh. Sampling ~1000 children between the ages of 9-17 months, we compared problem-solving, communication, motor and personal-social outcomes assessed by the Ages and Stages Questionnaire in the two interventions. After controlling for variables such as home stimulation in multivariate regressions, children in crèches performed about a quarter of a standard deviation better in total scores (p < 0...
September 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28953186/a-novel-mobility-device-to-improve-walking-for-a-child-with-cerebral-palsy
#19
Andrea Fergus
PURPOSE: To describe the use and outcomes associated with the Upsee in conjunction with Kinesiotape for a child with cerebral palsy. DESCRIPTIONS: The Upsee and Kinesiotaping were implemented for 24 weeks with a 31-month-old child with cerebral palsy, Gross Motor Function Classification System level III. OUTCOMES: She progressed from walking with maximal assistance and extensive gait deviations to walking with supervision with a walker on level surfaces with improved gait...
October 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28953185/creative-dance-practice-improves-postural-control-in-a-child-with-cerebral-palsy
#20
Kate Stribling, Jennifer Christy
PURPOSE: To investigate the effect of creative dance instruction on postural control and balance in an 11-year-old with spastic triplegic cerebral palsy, Gross Motor Function Classification Scale level II. DESCRIPTIONS: We conducted 1-hour dance interventions twice weekly for 8 weeks, with a focus on somatosensory awareness and movement in all planes of motion. Computerized dynamic posturography using the SMART Balance Master/EquiTest (NeuroCom) was used to assess postural control and balance reactions before the first class and following the final class...
October 2017: Pediatric Physical Therapy
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