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Gross Motor

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https://www.readbyqxmd.com/read/29467709/delayed-latency-of-postural-muscles-of-individuals-with-intellectual-disabilities
#1
J Walter Tolentino-Castro, Andreas Mühlbeier, Luis Mochizuki, Heiko Wagner
Individuals with intellectual disabilities (ID) (50 < IQ < 79) show impaired motor and postural control, these impairments are highly related to falls and injuries. Recent studies demonstrated these impairments are related with fine and gross motor development, which are more strongly associated with cognition, and consequently language for individuals with ID than for without ID. Despite these studies, little is known about the structure and functioning of this population's spinal cord, which is highly involved in postural control...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29465610/col6a-and-lama2-mutation-congenital-muscular-dystrophy-a-clinical-and-electrophysiological-study
#2
Sumit Verma, Parul Goyal, Lokesh Guglani, Charlotte Peinhardt, Diane Pelzek, Paul E Barkhaus
OBJECTIVES: COL6A and LAMA2 are subtypes of congenital muscular dystrophy. METHODS: Retrospective chart review of clinical findings, spirometry, muscle histology, muscle ultrasound, neuroimaging, and Electromyography (EMG)/Nerve Conduction Study data in genetically confirmed COL6A and LAMA2 subjects. RESULTS: We identified 8 COL6A and 6 LAMA2 subjects: the female-to-male ratio was 1.3:1 and the mean age was 11.9 ± 3.6 years. Gross motor delays since birth, proximal muscle weakness, and contractures were noted in both groups...
March 2018: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29463142/levonorgestrel-emergency-contraceptive-pills-use-during-breastfeeding-effect-on-infants-health-and-development
#3
Omar M Shaaban, Ahmed M Abbas, Hanaa R Mahmoud, Entsar M Yones, Ahmed Mahmoud, Mahmoud S Zakherah
OBJECTIVE: The current study aims to evaluate the effect of the use of single packet of levonorgestrel emergency contraceptive pills (LNG-ECPs) during breastfeeding on the health and development of the nursing infant. MATERIALS AND METHODS: The current study was an ancillary observational cohort study carried out in a university hospital. We counseled all women delivered and planning birth-space and breastfeed for at least 1 year for participation during postpartum hospital stay...
February 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29460553/can-early-physical-therapy-positively-affect-the-onset-of-independent-walking-in-infants-with-down-syndrome-a-retrospective-cohort-study
#4
Bruno Corrado, Nadia Sommella, Gianluca Ciardi, Enza Raiano, Iris Scala, Pietro Strisciuglio, Clemente Servodio Iammarrone
BACKGROUND: The development of both gross and fine motor skills in a child with Down syndrome is generally delayed. The most seriously affected stage is the achievement of independent walking ability, which influences the onset of all following motor and cognityive skills. The study objectives were (a) to assess the time taken to achieve independent walking ability in a cohort of children with Down syndrome, (b) to examine differences in walking onset by patient characteristics, (c) to verify the effect of early physical therapy (Neurodevelopmental Treatment on the basis of Bobath Concept practised within the first months of life) in the achievement of that skill...
February 19, 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29459115/inflammatory-bowel-disease-and-risk-of-parkinson-s-disease-in-medicare-beneficiaries
#5
Alejandra Camacho-Soto, Anat Gross, Susan Searles Nielsen, Neelendu Dey, Brad A Racette
INTRODUCTION: Gastrointestinal (GI) dysfunction precedes the motor symptoms of Parkinson's disease (PD) by several years. PD patients have abnormal aggregation of intestinal α-synuclein, the accumulation of which may be promoted by inflammation. The relationship between intestinal α-synuclein aggregates and central nervous system neuropathology is unknown. Recently, we observed a possible inverse association between inflammatory bowel disease (IBD) and PD as part of a predictive model of PD...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29456358/surgically-treated-primary-spinal-cord-neoplasms-in-southeastern-nigeria
#6
Mark Chukwunweike Chikani, Okwuoma Okwunodulu, Mathew Mesi, Wilfred C Mezue, Samuel C Ohaegbulam, Chika C Ndubuisi
Background: Primary spinal cord tumors are not as frequently encountered as their cranial counterparts. They could present in such an indolent manner that requires a reasonable index of suspicion for their diagnosis to be considered. Objective: The objective of this study is to analyze the incidence and pattern of primary spinal cord and appendage neoplasms in patients surgically treated in our institution over a decade of practice. Materials and Methods: A retrospective review of clinical, radiological, and histopathology profiles of patients surgically treated for primary spinal cord tumor from 2006 to 2016 was carried out...
January 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29451702/severity-of-cerebral-palsy-and-likelihood-of-adverse-events-after-botulinum-toxin-a-injections
#7
Caitlyn M Swinney, Karen Bau, Karen L Oakley Burton, Stephen J O'Flaherty, Natasha L Bear, Simon P Paget
AIM: To determine the incidence of common adverse events after botulinum toxin A (BoNT-A) injections in children with cerebral palsy (CP) and to identify whether the severity of CP influences the incidence of adverse events. METHOD: This was an observational study of patients attending a BoNT-A clinic at a tertiary paediatric hospital (2010-2014). Data examined included procedural adverse events at the time of injection and at follow-up. Systemic adverse events were defined as lower respiratory tract illnesses, generalized weakness, dysphagia, and death...
February 16, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29450629/congenital-cervical-kyphosis-in-an-infant-with-ehlers-danlos-syndrome
#8
Andrew J Kobets, Daniel Komlos, John K Houten
BACKGROUND: Ehler-Danlos syndome (EDS) refers to a group of heritable connective tissue disorders; rare manifestations of which are cervical kyphosis and clinical myelopathy. Surgical treatment is described for the deformity in the thoracolumbar spine in adolescents but not for infantile cervical spine. Internal fixation for deformity correction in the infantile cervical spine is challenging due to the diminutive size of the bony anatomy and the lack of spinal instrumentation specifically designed for young children...
February 15, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29446787/the-treatment-of-femoral-fractures-in-children-with-cerebral-palsy
#9
P Persiani, M Murgia, F M Ranaldi, O Mazza, M Mariani, M Crostelli, C Villani
OBJECTIVE: The purpose of this study is to retrospectively evaluate a group of children affected by cerebral palsy with a recent femoral fracture, and to analyse the results and complications in relation to the treatment used. MATERIALS AND METHODS: The analysis was performed on 36 children (21 M, 15 F, 8-14 years old) with cerebral palsy (7 diplegia, 28 tetraparesis, 1 hemiplegia) with a metaphyseal or a diaphyseal femoral fracture. The patients were subdivided into two groups according to their Gross Motor Function Classification System (GMFCS) level: level 2-3 (9 patients) and level 4-5 (27 patients), evaluating the presence of complications and malunions for each group at the end of each follow up...
January 2018: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29446202/conditional-deletion-of-cadherin-13-perturbs-golgi-cells-and-disrupts-social-and-cognitive-behaviors
#10
Martesa Tantra, Lanboling Guo, Jinsook Kim, Norliyana Zainolabidin, George J Augustine, Volker Eulenburg, Albert I Chen
Inhibitory interneurons mediate the gating of synaptic transmission and modulate the activities of neural circuits. Disruption of the function of inhibitory networks in the forebrain is linked to impairment of social and cognitive behaviors, but the involvement of inhibitory interneurons in the cerebellum has not been assessed. We found that Cadherin 13 (Cdh13), a gene implicated in autism spectrum disorder and attention-deficit hyperactivity disorder, is specifically expressed in Golgi cells within the cerebelluar cortex...
February 15, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29443730/prospective-associations-between-measures-of-gross-and-fine-motor-coordination-in-infants-and-objectively-measured-physical-activity-and-sedentary-behavior-in-childhood-erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29438658/functional-capacity-in-adults-with-cerebral-palsy-lower-limb-muscle-strength-matters
#12
Jarred G Gillett, Glen A Lichtwark, Roslyn N Boyd, Lee A Barber
OBJECTIVE: To investigate the relationship between lower limb muscle strength, passive muscle properties and functional capacity outcomes in adults with cerebral palsy (CP). DESIGN: Cross-sectional study. SETTING: Tertiary institution biomechanics laboratory. PARTICIPANTS: Sample of 33 adults with spastic-type CP with a mean age of 25 (range, 15-51) years; mean ± SD body mass 70.15 ± 21.35 kg; Gross Motor Function Classification System (GMFCS) level I n=20, level II n=13...
February 10, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29438131/improved-neurodevelopment-following-antiretroviral-therapy-in-hiv-infected-children
#13
Laurén A Gómez, Claudia S Crowell, Irene Njuguna, Lisa M Cranmer, Dalton Wamalwa, Daisy Chebet, Vincent Otieno, Elizabeth Maleche-Obimbo, Melissa Gladstone, Grace John-Stewart, Sarah Benki-Nugent
BACKGROUND: Late HIV diagnosis following severe co-morbidity remains common in resource limited settings. Neurodevelopmental recovery during antiretroviral therapy (ART) for late-diagnosed children is understudied. We determined 6-month neurodevelopmental trajectories in HIV-infected children initiating ART during hospitalization. METHODS: HIV-infected children initiated ART following HIV diagnosis during hospitalization in Kenya. The Malawi Developmental Assessment Tool (MDAT) was administered after clinical stabilization within 1-month and at 6-months post-ART initiation...
February 12, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29433666/similarities-and-differences-in-child-development-from-birth-to-age-3-years-by-sex-and-across-four-countries-a-cross-sectional-observational-study
#14
Ilgi Ozturk Ertem, Vibha Krishnamurthy, Mphelekedzeni C Mulaudzi, Yanina Sguassero, Hakan Balta, Ozlem Gulumser, Burcu Bilik, Roopa Srinivasan, Benjamin Johnson, Geliang Gan, Lisa Calvocoressi, Veronika Shabanova, Brian W C Forsyth
BACKGROUND: Knowledge about typical development is of fundamental importance for understanding and promoting child health and development. We aimed to ascertain when healthy children in four culturally and linguistically different countries attain developmental milestones and to identify similarities and differences across sexes and countries. METHODS: In this cross-sectional, observational study, we recruited children aged 0-42 months and their caregivers between March 3, 2011, and May 18, 2015, at 22 health clinics in Argentina, India, South Africa, and Turkey...
March 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29433600/development-and-preliminary-testing-of-the-brief-developmental-assessment-an-early-recognition-tool-for-children-with-heart-disease
#15
Jo Wray, Katherine L Brown, Deborah Ridout, Monica Lakhanpaul, Liz Smith, Angie Scarisbrick, Sara O'Curry, Aparna Hoskote
Introduction Neurodevelopmental abnormalities are common in children with CHD and are the highest-priority concerns for parents and professionals following cardiac surgery in childhood. There is no additional routine monitoring of development for children with CHD in the United Kingdom; hence, neurodevelopmental concerns may be detected late, precluding early referral and intervention. METHODS: An early recognition tool - the "Brief Developmental Assessment" - was developed using quality improvement methodology involving several iterations and rounds of pilot testing...
February 13, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29433091/the-influence-of-lower-limb-impairments-on-racerunning-performance-in-athletes-with-hypertonia-ataxia-or-athetosis
#16
Marietta L van der Linden, Sadaf Jahed, Nicola Tennant, Martine H G Verheul
OBJECTIVES: RaceRunning enables athletes with limited or no walking ability to propel themselves independently using a three-wheeled running bike that has a saddle and a chest plate for support but no pedals. For RaceRunning to be included as a Para athletics event, an evidence-based classification system is required. Therefore, the aim of this study was to assess the association between a range of impairment measures and RaceRunning performance. METHODS: The following impairment measures were recorded: lower limb muscle strength assessed using Manual Muscle Testing (MMT), selective voluntary motor control assessed using the Selective Control Assessment of the Lower Extremity (SCALE), spasticity recorded using both the Australian Spasticity Assessment Score (ASAS) and Modified Ashworth Scale (MAS), passive range of motion (ROM) of the lower extremities and the maximum static step length achieved on a stationary bike (MSSL)...
February 5, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29432173/a-posttranslational-modification-of-the-mitotic-kinesin-eg5-that-enhances-its-mechanochemical-coupling-and-alters-its-mitotic-function
#17
Joseph M Muretta, Babu J N Reddy, Guido Scarabelli, Alex F Thompson, Shashank Jariwala, Jennifer Major, Monica Venere, Jeremy N Rich, Belinda Willard, David D Thomas, Jason Stumpff, Barry J Grant, Steven P Gross, Steven S Rosenfeld
Numerous posttranslational modifications have been described in kinesins, but their consequences on motor mechanics are largely unknown. We investigated one of these-acetylation of lysine 146 in Eg5-by creating an acetylation mimetic lysine to glutamine substitution (K146Q). Lysine 146 is located in the α2 helix of the motor domain, where it makes an ionic bond with aspartate 91 on the neighboring α1 helix. Molecular dynamics simulations predict that disrupting this bond enhances catalytic site-neck linker coupling...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29431140/bike-skills-training-for-children-with-cerebral-palsy-protocol-for-a-randomised-controlled-trial
#18
Rachel Toovey, Adrienne R Harvey, Jennifer L McGinley, Katherine J Lee, Sophy T F Shih, Alicia J Spittle
INTRODUCTION: Two-wheel bike riding can be a goal for children with cerebral palsy (CP) and a means of participating in physical activity. It is possible for some children with CP to ride a two-wheel bike; however, currently far fewer can ride compared with their typically developing peers. Evidence supports training targeted towards goals of the child with CP and their family; yet there is little evidence to guide best-practice bike skills training. Task-specific training may lead to attainment of two-wheel bike-specific goals...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29428154/neonatal-infection-in-children-with-cerebral-palsy-a-registry-based-cohort-study
#19
Anne-Sophie Smilga, Jarred Garfinkle, Pamela Ng, John Andersen, David Buckley, Darcy Fehlings, Adam Kirton, Ellen Wood, Esias van Rensburg, Michael Shevell, Maryam Oskoui
BACKGROUND: The goal of this study was to explore the association between neonatal infection and outcomes in children with cerebral palsy. METHODS: We conducted a retrospective cohort study using the Canadian CP Registry. Neonatal infection was defined as meeting one of the following criteria: (1) septicemia, (2) septic shock, or (3) administration of antibiotics for ≥10 days. Phenotypic profiles of children with cerebral palsy with and without an antecedent neonatal infection were compared...
December 13, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29427287/determine-the-relationship-between-abdominal-muscle-strength-trunk-control-and-urinary-incontinence-in-children-with-diplegic-cerebral-palsy
#20
Burcu Talu
PURPOSE: The aim of this study is to determine the relationship between abdominal muscle strength, trunk control and urinary incontinence in children with diplegic cerebral palsy. MATERIALS AND METHODS: The current study had a cross-sectional design using analytical study as well as an observational research model. Fifty children between the ages of 5 and 18 years who were diagnosed with diplegic clinical type of cerebral palsy were included in this study using improbable-random sampling method...
February 10, 2018: Urology Journal
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