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JOURNAL ARTICLE
Karthik Ramachandran, Madhanmohan Chandramohan, Ajoy Prasad Shetty, Balavenkat Subramanian, Rishi Mugesh Kanna, Shanmuganathan Rajasekaran
STUDY DESIGN: Prospective, randomized controlled study. OBJECTIVE: To assess the safety and efficacy of an ultrasound-guided ISP block for postoperative analgesia in posterior cervical laminectomy. METHODS: 88 patients requiring posterior cervical laminectomy were randomized into two groups, those who underwent ISP block with multimodal analgesia (ISPB group) and those with only multimodal analgesia (control group). Demographic details, intraoperative parameters (blood loss, duration of surgery, perioperative total opioid consumption, muscle relaxants used), and postoperative parameters (numeric rating scale, satisfaction score, mobilization time, and complications) were recorded...
May 10, 2024: Global Spine Journal
#2
JOURNAL ARTICLE
Shinduk Lee, Marcia G Ory, Deborah Vollmer Dahlke, Matthew Lee Smith
BACKGROUND: Informal caregivers are called upon to provide substantial care, but more needs to be known about technology use among older adult and caregiver dyads. OBJECTIVE: This study described technology use among older adults and their caregivers, explored potential correlates of technology use, and highlighted implications for practice. METHODS: A cross-sectional survey was conducted among unpaid caregivers of older adults (n=486). Primary outcomes were self-reported technology (devices and functions) use among caregivers and their oldest care recipient...
May 1, 2024: JMIR aging
#3
JOURNAL ARTICLE
Kristen Hughes, Madison Cole, Deann Tims, Troy Wallach, Christopher Spencer, Vanice Page, Jennifer Robertson, James M Hoffman
BACKGROUND AND OBJECTIVES: Intravenous infusions have the potential to cause significant harm in patients and are associated with a high rate of adverse drug events and medication errors. Infusion pumps with dose error reduction software (DERS) can be used to reduce errors by establishing safe infusion parameters. In 2019, a quality improvement project was initiated with the aim to increase DERS compliance from 46% to 75% at our specialty institution by October 1, 2022. METHODS: An interdisciplinary group was tasked with improving compliance with DERS by identifying key drivers, including informed staff, engaged staff, and an accurate smart pump library...
May 8, 2024: Hospital Pediatrics
#4
JOURNAL ARTICLE
Erhan Okay, Joseph J Connolly, Marcos R Gonzalez, Santiago A Lozano-Calderon
In oncologic patients, optimal postoperative wound healing is crucial for the maintenance of systemic therapies and improved survival. Although several risk factors for postoperative wound complications have been identified, the clinical effect of new antineoplastic agents on wound healing remains uncertain. The available literature on the effect of antineoplastic agents in wound healing is complex to analyze because of other confounding risk factors such as radiation therapy and certain patient-specific variables...
May 2, 2024: Journal of the American Academy of Orthopaedic Surgeons
#5
Yuhan Bao, Jingbo Wang, Jie Xue
BACKGROUND: The metastasis of primary breast invasive lobular carcinoma to the gastrointestinal tract and skin is a rare phenomenon, with the simultaneous occurrence of both transfers being more uncommon. CASE PRESENTATION: This article reports a case of a patient with hormone receptor-positive, HER2-negative breast invasive lobular carcinoma with gastrointestinal tract and skin metastases. The patient was assessed by a second-look ultrasound and diagnosed by subsequent ultrasound-guided needle biopsy...
April 30, 2024: Current medical imaging
#6
JOURNAL ARTICLE
Lisa Mikesell, Denalee M O'Malley, Rachel T Kurtzman, Jenna Howard, Benjamin Bates, Jennifer R Hemler, Sarah J Fadem, Jeanne M Ferrante, Alicja Bator, Shawna V Hudson, Benjamin F Crabtree
INTRODUCTION: Existing approaches in cancer survivorship care delivery have proven to be insufficient to engage primary care. This study aimed to identify stakeholder-informed priorities to improve primary care engagement in breast cancer survivorship care. METHODS: Experts in U.S. cancer survivorship care delivery were invited to participate in a 4-round online Delphi panel to identify and evaluate priorities for defining and fostering primary care's engagement in breast cancer survivorship...
May 2024: Cancer Medicine
#7
JOURNAL ARTICLE
Sushant Sharma Chaudhary, Andrew Toivonen, Gaurav Waratkar, Geoffrey Mo, Deep Chatterjee, Sarah Antier, Patrick Brockill, Michael W Coughlin, Reed Essick, Shaon Ghosh, Soichiro Morisaki, Pratyusava Baral, Amanda Baylor, Naresh Adhikari, Patrick Brady, Gareth Cabourn Davies, Tito Dal Canton, Marco Cavaglia, Jolien Creighton, Sunil Choudhary, Yu-Kuang Chu, Patrick Clearwater, Luke Davis, Thomas Dent, Marco Drago, Becca Ewing, Patrick Godwin, Weichangfeng Guo, Chad Hanna, Rachael Huxford, Ian Harry, Erik Katsavounidis, Manoj Kovalam, Alvin K Y Li, Ryan Magee, Ethan Marx, Duncan Meacher, Cody Messick, Xan Morice-Atkinson, Alexander Pace, Roberto De Pietri, Brandon Piotrzkowski, Soumen Roy, Surabhi Sachdev, Leo P Singer, Divya Singh, Marek Szczepanczyk, Daniel Tang, Max Trevor, Leo Tsukada, Verónica Villa-Ortega, Linqing Wen, Daniel Wysocki
Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has resumed with ALIGO's, AdVirgo's and KAGRA's fourth observing run (O4). To support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of compact binaries and a mock data challenge (MDC) in the form of a real-time replay to optimize and profile the software infrastructure and scientific deliverables...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#8
JOURNAL ARTICLE
Vallal Kani, Kavitha K, Sulochana Sonti
Introduction Pre-analytical errors in cytology laboratories can significantly impact the accuracy of diagnostic results and turnaround times, ultimately affecting patient care. This article presents an evaluation of pre-analytical errors and proposes fostering strategies to enhance accuracy and efficiency in the cytology laboratory of a tertiary care hospital. The background discusses the importance of pre-analytical processes in ensuring reliable cytological diagnoses and the common errors encountered in specimen collection, handling, and transportation...
March 2024: Curēus
#9
JOURNAL ARTICLE
Ambarish Vaidyanathan, Abigail Gates, Claudia Brown, Emily Prezzato, Aaron Bernstein
Unprecedented heat waves can affect all persons, but some are more sensitive to the effects of heat, including children and adults with underlying health conditions, pregnant women, and outdoor workers. Many regions of the United States experienced record-breaking high temperatures in 2023, with populations exposed to extremely high temperatures for prolonged periods. CDC examined emergency department (ED) visits associated with heat-related illness (HRI) from the National Syndromic Surveillance Program and compared daily HRI ED visit rates during the warm-season months (May-September) of 2023 with those during 2018-2022...
April 18, 2024: MMWR. Morbidity and Mortality Weekly Report
#10
JOURNAL ARTICLE
Min Chen, Siyuan Chen, Xinyu Wang, Zongjian Ye, Kehan Liu, Yijing Qian, Meng Tang, Tianshu Wu
BACKGROUND: Recently, carbon quantum dots (CQDs) have been widely used in various fields, especially in the diagnosis and therapy of neurological disorders, due to their excellent prospects. However, the associated inevitable exposure of CQDs to the environment and the public could have serious severe consequences limiting their safe application and sustainable development. RESULTS: In this study, we found that intranasal treatment of 5 mg/kg BW (20 µL/nose of 0...
April 10, 2024: Particle and Fibre Toxicology
#11
JOURNAL ARTICLE
Merel van Nuland, JaapJan D Snoep, Toine Egberts, Abdullah Erdogan, Ricky Wassink, Paul D van der Linden
PURPOSE: Clinical decision support systems (CDSS) are used to identify drugs with potential need for dose modification in patients with renal impairment. ChatGPT holds the potential to be integrated in the electronic health record (EHR) system to give such dosing advices. In this study, we aim to evaluate the performance of ChatGPT in clinical rule-guided dose interventions in hospitalized patients with renal impairment. METHODS: This cross-sectional study was performed at Tergooi Medical Center, the Netherlands...
April 9, 2024: European Journal of Clinical Pharmacology
#12
JOURNAL ARTICLE
Shahinda Rezk, Nourhan Ashraf, Hassan Heshmat, Gamal Elsawaf, Amel Elsheredy
Bloodstream infections (BSIs) caused by multidrug-resistant bacteria are a critical life-threatening challenge which necessitates the urgency to trigger life-saving treatment in a timely manner. This study aimed to evaluate the time required for rapid detection of carbapenemase-producing Enterobacterales (CPE) directly from blood culture bottles to optimize empirical treatment of BSI, especially in pediatric and infant patients, using a cost-effective method. This study included 419 Gram-negative bacteria, of which Klebsiella pneumoniae and Escherichia coli were the most common CPE causing BSI in pediatric and neonatal patients...
April 4, 2024: Acta Microbiologica et Immunologica Hungarica
#13
Mukuto Shioda, Hiroaki Fujita, Hiroki Onuma, Hirotaka Sakuramoto, Mai Hamaguchi, Keisuke Suzuki
A 79-year-old man was admitted for 2 weeks of dizziness, followed by diplopia, involuntary movement and progressive gait disturbances. Neurologic examination revealed horizontal and vertical gaze paresis, bilateral choreiform movement with orofacial dyskinesia, and limb/truncal ataxia. MRI revealed fluid-attenuated inversion recovery image-hyperintense signal abnormalities in the dorsal midbrain, pontine and medulla. Within another few days, the patient developed type II acute respiratory failure requiring artificial invasive ventilation...
2024: Frontiers in Neurology
#14
JOURNAL ARTICLE
Darren Johnson, Guilherme Del Fiol, Kensaku Kawamoto, Katrina M Romagnoli, Nathan Sanders, Grace Isaacson, Elden Jenkins, Marc S Williams
OBJECTIVES: Patient care using genetics presents complex challenges. Clinical decision support (CDS) tools are a potential solution because they provide patient-specific risk assessments and/or recommendations at the point of care. This systematic review evaluated the literature on CDS systems which have been implemented to support genetically guided precision medicine (GPM). MATERIALS AND METHODS: A comprehensive search was conducted in MEDLINE and Embase, encompassing January 1, 2011-March 14, 2023...
April 1, 2024: Journal of the American Medical Informatics Association: JAMIA
#15
JOURNAL ARTICLE
Natasha J Petry, Joel Van Heukelom, April J Schultz, Kristen Jacobsen, Jordan F Baye, Sarah Mills, Debbie Figueroa, Amanda Massmann
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: We describe the implementation and ongoing maintenance of CYP2C19 and CYP2D6 focused pharmacogenetic (PGx) testing to guide antidepressant and antianxiety medication prescriptions in a large rural, nonprofit health system...
March 28, 2024: American Journal of Health-system Pharmacy: AJHP
#16
JOURNAL ARTICLE
Bodil Holmberg, Anders Svensson, Adam Helge, Anders Bremer
AIM: To describe ambulance clinicians' experiences of self-determination in older patients. DESIGN: The study had an inductive and explorative design, guided from a life-world perspective. METHODS: Thirty-two Swedish ambulance clinicians were interviewed in six focus groups in November 2019. The data were analysed with content analysis, developing manifest categories and latent themes. FINDINGS: The ambulance clinicians assessed the older patients' exercise of self-determination by engaging in conversation and by being visually alert, to eventually gain an overall picture of their decision-making capacity...
March 24, 2024: Journal of Advanced Nursing
#17
JOURNAL ARTICLE
Zhong Chen, Liyan Lin, Liqun Xu, Renhe Lin, Xiaoling Jiang
RATIONALE: Primary adrenal lymphoma (PAL) is a very rare and highly aggressive disease. Neurolymphomatosis (NL) is a rare manifestation of lymphoma characterized by the infiltration of lymphoma cells into peripheral nerves, resulting in neurological symptoms. To date, there have been very few reported cases of PAL with NL. By reviewing the entire treatment process of the patient, we aim to enhance recognition of PAL complicated with NL and guide clinicians to pay attention to the diagnosis of such diseases...
March 22, 2024: Medicine (Baltimore)
#18
JOURNAL ARTICLE
Yujin Qu, Jinli Bai, Hui Jiao, Hong Qi, Wenchen Huang, Shijia OuYang, Xiaoyin Peng, Yuwei Jin, Hong Wang, Fang Song
Accurate genetic diagnosis is necessary for guiding the treatment of spinal muscular atrophy (SMA). An updated consensus for the diagnosis and management of SMA was published in 2018. However, clinicians should remain alert to some pitfalls of genetic testing that can occur when following a routine diagnosis. In this study, we report the diagnosis of three unrelated individuals who were initially misdiagnosed as carrying a homozygous deletion of SMN1 exon 7. MLPA (P060 and P021) and qPCR were used to detect the copy number of SMN ...
March 30, 2024: Heliyon
#19
Cherry Bansal, Amanpreet Singh, Dimple Kapoor, Charu Nayyar, Mohammed Nadeem Shaikh, P C Swami
Testicular mixed germ cell tumors (TMGCTs) are rare malignant tumors comprising of two or more types of germ cell tumors. Their onset may be undetectable and the patient may first present with symptoms of metastasis. We hereby report a case of a young male who presented with respiratory discomfort and had no symptoms of primary testicular tumor. CT-guided FNAC lung revealed mainly necrotic, keratinous debris with a focus of chondromyxoid stroma. Differential diagnoses of components of teratoma, squamous cell carcinoma and inclusion cyst was considered...
March 2024: Indian Journal of Surgical Oncology
#20
JOURNAL ARTICLE
Frances Fengzhi Lin, Yingyan Chen, Megan Rattray, Lauren Murray, Kylie Jacobs, Jane Brailsford, Patricia Free, Peter Garrett, Alexis Tabah, Mahesh Ramanan
OBJECTIVES: To identify and synthesise interventions and implementation strategies to optimise patient flow, addressing admission delays, discharge delays, and after-hours discharges in adult intensive care units. METHODS: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Five electronic databases, including CINAHL, PubMed, Emcare, Scopus, and the Cochrane Library, were searched from 2007 to 2023 to identify articles describing interventions to enhance patient flow practices in adult intensive care units...
March 16, 2024: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
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