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https://www.readbyqxmd.com/read/29259215/site-specific-chromosomal-gene-insertion-flp-recombinase-versus-cas9-nuclease
#1
Quang Vinh Phan, Jörg Contzen, Petra Seemann, Manfred Gossen
Site-specific recombination systems like those based on the Flp recombinase proved themselves as efficient tools for cell line engineering. The recent emergence of designer nucleases, especially RNA guided endonucleases like Cas9, has considerably broadened the available toolbox for applications like targeted transgene insertions. Here we established a recombinase-mediated cassette exchange (RMCE) protocol for the fast and effective, drug-free isolation of recombinant cells. Distinct fluorescent protein patterns identified the recombination status of individual cells...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205262/perceptions-on-the-value-of-bodily-functions-in-multiple-sclerosis
#2
C Heesen, R Haase, S Melzig, J Poettgen, M Berghoff, P Friedemann, U Zettl, M Marziniak, K Angstwurm, R Kern, T Ziemssen, J P Stellmann
BACKGROUND: In neurological diseases presenting with a plethora of symptoms, the value of bodily functions for a given patient might be a guide for clinical management. Multiple sclerosis (MS) is paradigmatic in this respect, and little is known about the value of different bodily functions of patients and their physicians' perceptions. METHODS: In a multicenter study, 171 patients with relapsing-remitting multiple sclerosis (RRMS), 61% with a clinically active disease within the last 2 years were followed over up to 3 years and yearly patients and their study physician rated on the perceived value of 13 bodily functions via a priority list...
December 3, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29203458/evaluating-in-car-movements-in-the-design-of-mindful-commute-interventions-exploratory-study
#3
Pablo Enrique Paredes, Nur Al-Huda Hamdan, Dav Clark, Carrie Cai, Wendy Ju, James A Landay
BACKGROUND: The daily commute could be a right moment to teach drivers to use movement or breath towards improving their mental health. Long commutes, the relevance of transitioning from home to work, and vice versa and the privacy of commuting by car make the commute an ideal scenario and time to perform mindful exercises safely. Whereas driving safety is paramount, mindful exercises might help commuters decrease their daily stress while staying alert. Increasing vehicle automation may present new opportunities but also new challenges...
December 4, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29183232/a-qsar-and-molecular-modelling-study-towards-new-lead-finding-polypharmacological-approach-to-mycobacterium-tuberculosis
#4
S Janardhan, L John, M Prasanthi, V Poroikov, G Narahari Sastry
Developing effective inhibitors against Mycobacterium tuberculosis (Mtb) is a challenging task, primarily due to the emergence of resistant strains. In this study, we have proposed and implemented an in silico guided polypharmacological approach, which is expected to be effective against resistant strains by simultaneously inhibiting several potential Mtb drug targets. A combination of pharmacophore and QSAR based virtual screening strategy taking three key targets such as InhA (enoyl-acyl-carrier-protein reductase), GlmU (N-acetyl-glucosamine-1-phosphate uridyltransferase) and DapB (dihydrodipicolinate reductase) have resulted in initial 784 hits from Asinex database of 435,000 compounds...
October 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29170334/37%C3%A2-routine-testing-of-salicylate-levels-in-overdose-patients-still-needed
#5
Elaine Hardy, Clare Toro, Susan Dorrian, Umesh Salanke
INTRODUCTION AND AIMS: Overdose is a common presentation in Emergency Departments (EDs) across the UK. Salicylate poisoning is potentially fatal; however it is becoming increasingly uncommon in the UK. This may be due to restriction of pack sizes in over the counter medicines as well as the use of aspirin as an analgesic being superseded by other NSAIDs, particularly ibuprofen.In conjunction with clinical features of salicylate toxicity, measurement of plasma salicylate concentration can help guide management...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29169817/the-french-infectious-diseases-society-s-readiness-and-response-to-epidemic-or-biological-risk-the-current-situation-following-the-middle-east-respiratory-syndrome-coronavirus-and-ebola-virus-disease-alerts
#6
H Coignard-Biehler, C Rapp, J M Chapplain, B Hoen, D Che, P Berthelot, F Cazenave-Roblot, C Rabaud, P Brouqui, C Leport
CONTEXT: In 2012, the French Infectious Diseases Society (French acronym SPILF) initiated the "Coordination of epidemic and biological risk" (SPILF-COREB - Emergences [SCE]) group to support the readiness and response of healthcare workers (HCWs) to new alerts. OBJECTIVE: To present the SCE group, its functioning, and the main support it provided for frontline HCWs. METHODS: A multidisciplinary group of heads of infectious disease departments from reference hospitals was created to build a network of clinical expertise for care, training, and research in the field of epidemic and biological risk (EBR)...
November 20, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29103654/equilibrium-sampling-informs-tissue-residue-and-sediment-remediation-for-pyrethroid-insecticides-in-mariculture-a-laboratory-demonstration
#7
Juan-Ying Li, Wenxuan Shi, Zhenhua Li, Yiqin Chen, Liu Shao, Ling Jin
Mariculture product safety in relation to sediment quality has attracted increasing attention because of the accumulation of potentially hazardous chemicals, including pyrethroid insecticides, in sediment. Passive sampling has been widely used to assess the bioavailability of sediment-associated hydrophobic organic contaminants and predict their body residue in benthic organisms. Therefore, in this study, we introduced polydimethylsiloxane (PDMS) polymer as a biomimetic "chemometer" for freely-dissolved concentrations (Cfree) to assess the efficacy of different carbon sorbents in reducing the bioavailability of pyrethroids in the process of sediment remediation...
November 2, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29101393/sensory-coding-accuracy-and-perceptual-performance-are-improved-during-the-desynchronized-cortical-state
#8
Charles B Beaman, Sarah L Eagleman, Valentin Dragoi
Cortical activity changes continuously during the course of the day. At a global scale, population activity varies between the 'synchronized' state during sleep and 'desynchronized' state during waking. However, whether local fluctuations in population synchrony during wakefulness modulate the accuracy of sensory encoding and behavioral performance is poorly understood. Here, we show that populations of cells in monkey visual cortex exhibit rapid fluctuations in synchrony ranging from desynchronized responses, indicative of high alertness, to highly synchronized responses...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29079370/impact-of-an-emergency-medicine-pharmacist-on-initial-antibiotic-prophylaxis-for-open-fractures-in-trauma-patients
#9
Somer Harvey, A Brad Hall, Kayla Wilson
BACKGROUND: Targeted antibiotic treatment reduces the infection risk of open fractures when soft tissue and bone are exposed to the environment. The risk of infection increases with higher degrees of injury. The Gustilo-Anderson system was developed to identify the degree of injury of open fractures and can be utilized to guide initial antibiotic therapy. Few studies have been published evaluating the potential impact of emergency medicine pharmacists in trauma, and currently no study has evaluated a pharmacist's influence on antibiotic selection and timing for open fractures...
October 17, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29076209/oral-health-matters-for-the-nutritional-status-of-older-persons-a-population-based-study
#10
Ulrika Lindmark, Henrik Jansson, Christina Lannering, Linda Johansson
AIM AND OBJECTIVE: The aim of this study was to explore the association between oral health and nutritional status in the context of daily care for older people. BACKGROUND: Oral problems often increase with age and affect a person's ability to chew and swallow. They might also influence the ability to maintain a satisfactory nutritional status. Oral health awareness is therefore of great importance in nursing care for older people. METHODS: Data from the Swedish quality register, Senior Alert, were used, including structured assessments of both oral and nutritional status using the Revised Oral Assessment Guide - Jönköping (ROAG-J) and the Mini Nutritional Assessment (MNA)...
October 27, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28992491/photolysis-of-clethodim-herbicide-and-a-formulation-in-aquatic-environments-fate-and-ecotoxicity-assessment-of-photoproducts-by-qsar-models
#11
Juan José Villaverde, Beatriz Sevilla-Morán, Carmen López-Goti, Luisa Calvo, José Luis Alonso-Prados, Pilar Sandín-España
The photochemical fate of the herbicide clethodim in natural waters was investigated under simulated and natural sunlight radiation. This herbicide exhibited a rapid degradation rate in simulated aquatic environment with half-lives ranged from 27.9min to 4.6h. The commercial formulation of clethodim showed a faster degradation with half-lives from 19.3min to 1.4h. It has also been demonstrated that the photolytic behavior of clethodim was affected by the water composition and the radiation intensity. Nine major photoproducts were identified and their distribution was dependent on the experimental conditions...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28981223/-child-behavior-disorder-clinical-reasoning-in-general-practice
#12
N Kacenelenbogen
CONTEXT: in Belgium 70 % of the children aged 0 - 14 years have at least one annual contact with their family doctor, while for the same period, only 6 - 12 % of them will see a neuropaediatrician and/or a child psychiatrist, despite the fact that a diagnostic of Externalizing behavior before the age of 6 to 7 years, such as various ways of aggressiveness, of anger or of stealing will very often alert the family, the staff of creches or nursery as well as the teachers. Other children are showing signs of Internalizing behavior, very often together with depression or other forms of anxiety...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28941390/severe-forms-of-food-allergy
#13
REVIEW
Emanuel Sarinho, Maria das Graças Moura Lins
OBJECTIVES: To guide the diagnostic and therapeutic management of severe forms of food allergy. DATA SOURCES: Search in the Medline database using the terms "severe food allergy," "anaphylaxis and food allergy," "generalized urticaria and food allergy," and "food protein-induced enterocolitis syndrome" in the last ten years, searching in the title, abstract, or keyword fields. SUMMARY OF DATA: Food allergy can be serious and life-threatening...
November 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28936715/comparing-different-partograph-designs-for-use-in-standard-labor-care-a-pilot-randomized-trial
#14
Nigel J Lee, Jeremy Neal, Nancy K Lowe, Sue V Kildea
Backgound Partographs are used in many labour settings to provide a pictorial overview of a woman's cervical dilation pattern in the first stage of labor and to alert clinicians to slow progress possibly requiring intervention. Recent reviews called for large trials to establish the efficacy of partographs to improve birth outcomes whilst highlighting issues of clinician compliance with use. Previous studies have also reported issues with participant recruitment related to concerns regarding the possibility of a longer labour...
September 21, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28935626/wide-variability-in-prethrombectomy-workflow-practices-in-the-united-states-a-multicenter-survey
#15
A P Kansagra, G C Meyers, M S Kruzich, D T Cross, C J Moran
BACKGROUND AND PURPOSE: Clinical outcomes in patients with acute ischemic stroke caused by large vessel occlusion depend on the speed and quality of workflows leading to mechanical thrombectomy. In the absence of universally accepted best practices for workflow, developing stroke hospitals can benefit from improved awareness of real-world workflows in effect at experienced centers. To this end, we surveyed prethrombectomy workflow practices at stroke centers throughout the United States...
September 21, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28928992/dental-implant-in-the-canalis-sinuosus-a-case-report-and-review-of-the-literature
#16
José Alcides Arruda, Pedro Silva, Luciano Silva, Pâmella Álvares, Leni Silva, Ricardo Zavanelli, Cleomar Rodrigues, Marleny Gerbi, Ana Paula Sobral, Marcia Silveira
The canalis sinuosus is a neurovascular canal, a branch of nerve of infraorbital canal, through which the anterior superior alveolar nerve passes and then leans medially in course between the nasal cavity and the maxillary sinus, reaching the premaxilla in the canine and incisor region. The purpose of this article is to report a case with the presence of canalis sinuosus, in order to alert and guide professionals and discuss the morphology of this anatomical variation avoiding trans- and postsurgical disorders in dental implants...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28902274/chikungunya-virus-outbreak-in-sint-maarten-2013-2014
#17
Maria Henry, Lorraine Francis, Virginia Asin, Karen Polson-Edwards, Babatunde Olowokure
This report describes the outbreak of chikungunya virus (CHIKV) in Sint Maarten, a constituent country of Kingdom of the Netherlands comprising the southern part of the Caribbean island of Saint Martin, from 22 December 2013 (first reported case) through 5 December 2014. The outbreak was first reported by the French overseas collectivity of Saint-Martin in the northern part of the island-the first site in the Americas to report autochthonous transmission of CHIKV. By 5 December 2014, Sint Maarten had reported a total of 658 cases-an overall attack rate of 1...
August 21, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28901659/using-gamma-index-to-flag-changes-in-anatomy-during-image-guided-radiation-therapy-of-head-and-neck-cancer
#18
Bryan Schaly, Jeff Kempe, Varagur Venkatesan, Sylvia Mitchell, Jerry J Battista
During radiation therapy of head and neck cancer, the decision to consider replanning a treatment because of anatomical changes has significant resource implications. We developed an algorithm that compares cone-beam computed tomography (CBCT) image pairs and provides an automatic alert as to when remedial action may be required. Retrospective CBCT data from ten head and neck cancer patients that were replanned during their treatment was used to train the algorithm on when to recommend a repeat CT simulation (re-CT)...
September 13, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28767580/metastatic-cardiac-tumor-presenting-as-atrial-fibrillation-in-a-previously-healthy-woman-a-case-report
#19
Chi-Wen Cheng, Ning-I Yang, Koon-Kwan Ng, Wen-Jin Cherng
RATIONALE: Metastatic cardiac tumor (MCT) is rare in clinical practice. MCT presenting initially as atrial fibrillation (AF) is even rarer. PATIENT CONCERNS: We report a 47-year-old woman with no previous medical history presented with intermittent palpitation for 3 days. DIAGNOSES: The electrocardiography showed AF with rapid ventricular rate. The transthoracic echocardiography showed a 4 × 4 cm mass occupying the left atrium (LA)...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28765076/utility-and-potential-of-rapid-epidemic-intelligence-from-internet-based-sources
#20
REVIEW
S J Yan, A A Chughtai, C R Macintyre
OBJECTIVES: Rapid epidemic detection is an important objective of surveillance to enable timely intervention, but traditional validated surveillance data may not be available in the required timeframe for acute epidemic control. Increasing volumes of data on the Internet have prompted interest in methods that could use unstructured sources to enhance traditional disease surveillance and gain rapid epidemic intelligence. We aimed to summarise Internet-based methods that use freely-accessible, unstructured data for epidemic surveillance and explore their timeliness and accuracy outcomes...
July 29, 2017: International Journal of Infectious Diseases: IJID
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