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https://www.readbyqxmd.com/read/28625838/comparison-of-time-to-detection-values-between-bact-alert-%C3%A2-virtuo%C3%A2-and-bact-alert-%C3%A2-3d-instruments-for-clinical-blood-cultures-samples
#1
Francesco Congestrì, Maria Federica Pedna, Michela Fantini, Michela Samuelli, Pasqua Schiavone, Arianna Torri, Stefania Bertini, Vittorio Sambri
OBJECTIVES: The early detection of bacteraemia and fungemia is of paramount importance to guide the antimicrobial therapy in septic patients. In this study the "time to detection" (TTD) values for the new blood culture system BacT/ALERT(®) VIRTUO™ (VIRTUO) was evaluated in 1462 positive clinical bottles and compared with the TTD identified for 1601 positive clinical bottles incubated in the BacT/ALERT(®) 3D (BTA 3D). METHODS: The most representative microorganisms isolated from bottles incubated in both blood culture systems were divided into 8 categories (in order of frequency): Coagulase-Negative-Staphylococci (CoNS), Escherichia coli, Enterobacteriaceae (other than E...
June 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28625599/disparities-in-anxiety-and-its-disorders
#2
EDITORIAL
Michael J Zvolensky, Lorra Garey, Jafar Bakhshaie
Much of the scientific work addressing the enigmas of anxiety and its disorders has been conducted among European Americans. This work has led to great progress into the nature of anxiety psychopathology, including etiologic, maintenance, and relapse processes. Moreover, evidenced-based treatments for anxiety and its disorders have arguably been among the best in the field of psychopathology for well over two decades. Yet, the progress thus far attained on the nature and treatment of anxiety disorders has not benefited all members of society equally...
May 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/28579472/identifying-environmental-reservoirs-of-clostridium-difficile-with-a-scent-detection-dog-preliminary-evaluation
#3
Elizabeth Bryce, Teresa Zurberg, Markus Zurberg, Salomeh Shajari, Diane Roscoe
BACKGROUND: Prompted by an article describing a dog trained to detect Clostridium difficile in patients, our institution evaluated a dog's ability to detect C. difficile scent from equipment and surfaces to assist in strategic deployment of adjunctive cleaning measures. METHODS: An expert in drug and explosives scent dog handling trained a canine to identify odours from pure cultures and/or faecal specimens positive for C. difficile. Methods used to assess explosive and drug detection dogs were adapted and included evaluation of a) odour recognition, using containers positive and negative for the scent of C...
June 1, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28549899/utility-of-published-dna-reactivity-alerts
#4
Alun Myden, Sebastien J Guesne, Alex Cayley, Richard V Williams
The identification of impurities with mutagenic potential is required for any potential pharmaceutical. The ICH M7 guidelines state that two complementary in silico toxicity prediction tools may be used to predict the mutagenic potential of pharmaceutical impurities. An expert review of the resulting in silico predictions is required, and numerous publications have been released to guide the expert review process. One such publication suggests that literature-based structural alerts (LBSAs) may provide a suitable aid in the expert review process...
May 23, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28543427/conservation-of-resources-theory-in-nurse-burnout-and-patient-safety
#5
Aoyjai Prapanjaroensin, Patricia A Patrician, David E Vance
AIMS: To examine how the Conservation of Resources theory explains burnout in the nursing profession. BACKGROUND: Burnout, which is an accumulation of work-related mental stress in people-oriented occupations, has been an issue of concern for decades for healthcare workers, especially nurses. Yet, few studies have examined a unified theory that explains the etiology, progression and consequences of nurse burnout. DESIGN: This discussion article integrates current knowledge on nurse burnout using Conservation of Resources theory, which focuses on four resources (i...
May 24, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28517959/pomics-a-simulation-disease-model-for-timing-fungicide-applications-in-management-of-powdery-mildew-of-cucurbits
#6
Zaiton Sapak, Moin U Salam, Elizabeth J Minchinton, Garry P V MacManus, Daryl Joyce, Victor Joseph Galea
A weather-based simulation model, called POMICS, was constructed to predict fungicide application scheduling to manage powdery mildew of cucurbits. The model was developed on the principle that conditions favorable for Podosphaera xanthii, a causal pathogen of this crop disease, generate a number of infection cycles in a single growing season. The model consists of two components that: (i) simulate the disease progression of P. xanthii in secondary infection cycles under natural conditions and (ii) predict the disease severity with application of fungicides at any recurrent disease cycles...
May 18, 2017: Phytopathology
https://www.readbyqxmd.com/read/28476284/pyoderma-gangrenosum-with-pathergy-a-potentially-significant-complication-following-breast-reconstruction
#7
D K Patel, M Locke, P Jarrett
The failure of postoperative surgical site infection to resolve after appropriate antibiotic therapy should alert the clinician to other diagnoses. Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis that is typically characterized by necrotizing ulceration. PG can be exacerbated by minor trauma leading to exaggerated skin injury, a condition known as pathergy. We present a case series of PG arising after immediate reconstruction for breast oncological surgery from 1st January 2006 to 1st September 2014...
April 12, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28452241/respiratory-monitoring-in-adult-intensive-care-unit
#8
Pongdhep Theerawit, Yuda Sutherasan, Lorenzo Ball, Paolo Pelosi
The mortality of patients with respiratory failure has steadily decreased with the advancements in protective ventilation and treatment options. Although respiratory monitoring per se has not been proven to affect the mortality of critically ill patients, it plays a crucial role in patients' care, as it helps to titrate the ventilatory support. Several new monitoring techniques have recently been made available at the bedside. The goals of monitoring comprise alerting physicians to detect the change in the patients' conditions, to improve the understanding of pathophysiology to guide the diagnosis and provide cost-effective clinical management...
June 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28415148/the-6-a-s-a-risk-manager-s-guide-to-emergency-cesarean-delivery
#9
Larry Veltman
The allegation of delay in performing an emergency cesarean delivery is common in litigation involving neurological injury to newborns. Analyzing the actual performance of an emergency cesarean involves multiple steps, individuals, and systemic processes that need coordination for appropriate action when necessary. This article gives risk managers a systematic way to evaluate a given perinatal unit's approach to the ability to perform an emergency cesarean through evaluating the 6 "A"s: Assess, Alert, Align, Assemble, Act, and Analyze...
April 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/28414152/rituximab-for-immunologic-renal-disease-what-the-nephrologist-needs-to-know
#10
REVIEW
Andreas Kronbichler, Martin Windpessl, Herwig Pieringer, David R W Jayne
Rituximab (RTX), a chimeric, monoclonal anti-CD20 antibody, is increasingly used in immune-mediated renal diseases. While licensed in the induction treatment of ANCA-associated vasculitis, it represents one of the most commonly prescribed off-label drugs. Much of the information regarding its safety has been drawn from experience in hematology and rheumatology. Ample evidence illustrates the safety of RTX, however, rare but serious adverse events have emerged that include progressive multifocal leucoencephalopathy and hepatitis B reactivation...
April 13, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28405953/angioedema-in-the-emergency-department-a-practical-guide-to-differential-diagnosis-and-management
#11
REVIEW
Jonathan A Bernstein, Paolo Cremonesi, Thomas K Hoffmann, John Hollingsworth
BACKGROUND: Angioedema is a common presentation in the emergency department (ED). Airway angioedema can be fatal; therefore, prompt diagnosis and correct treatment are vital. OBJECTIVE OF THE REVIEW: Based on the findings of two expert panels attended by international experts in angioedema and emergency medicine, this review aims to provide practical guidance on the diagnosis, differentiation, and management of histamine- and bradykinin-mediated angioedema in the ED...
December 2017: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28381249/cardiovascular-care-guideline-implementation-in-community-health-centers-in-oregon-a-mixed-methods-analysis-of-real-world-barriers-and-challenges
#12
Rachel Gold, Arwen Bunce, Stuart Cowburn, James V Davis, Celine Hollombe, Christine A Nelson, Jon Puro, John Muench, Christian Hill, Victoria Jaworski, MaryBeth Mercer, Colleen Howard, Nancy Perrin, Jennifer DeVoe
BACKGROUND: Spreading effective, guideline-based cardioprotective care quality improvement strategies between healthcare settings could yield great benefits, particularly in under-resourced contexts. Understanding the diverse factors facilitating or impeding such guideline implementation could improve cardiovascular care quality and outcomes for vulnerable patients. METHODS: We sought to identify multi-level factors affecting uptake of cardioprotective care guidelines in community health centers (CHCs), within a successful trial of cross-setting implementation of an effective intervention...
April 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28366353/comparing-fourier-optics-and-contrast-transfer-function-modeling-of-image-formation-in-low-energy-electron-microscopy
#13
K M Yu, A Locatelli, M S Altman
A theoretical understanding of image formation in cathode lens microscopy can facilitate image interpretation. We compare Fourier Optics (FO) and Contrast Transfer Function (CTF) approaches that were recently adapted from other realms of microscopy to model image formation in low energy electron microscopy (LEEM). Although these two approaches incorporate imaging errors from several sources similarly, they differ in the way that the image intensity is calculated. The simplification that is used in the CTF calculation advantageously leads to its computational efficiency...
March 24, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28359011/diagnostic-triage-for-low-back-pain-a-practical-approach-for-primary-care
#14
REVIEW
Lynn D Bardin, Peter King, Chris G Maher
Diagnostic triage is an essential guideline recommendation for low back pain (LBP), which is the most frequent musculoskeletal condition that general practitioners encounter in Australia. Clinical diagnosis of LBP - informed by a focused history and clinical examination - is the key initial step for GPs, and determines subsequent diagnostic workup and allied health and medical specialist referral. The goal of diagnostic triage of LBP is to exclude non-spinal causes and to allocate patients to one of three broad categories: specific spinal pathology (< 1% of cases), radicular syndrome (∼ 5-10% of cases) or non-specific LBP (NSLBP), which represents 90-95% of cases and is diagnosed by exclusion of the first two categories...
April 3, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28334561/determining-current-insulin-pen-use-practices-and-errors-in-the-inpatient-setting
#15
Katelyn E Brown, John B Hertig
BACKGROUND: The use of insulin pens in the inpatient setting has continued to be a controversial decision. Insulin pens provide several advantages, but given significant reports of medication errors, several organizations have issued alerts to caution users about safety concerns. A survey was conducted to assess the prevalence of insulin pen use and current utilization trends in the inpatient setting. METHODS: The 31-question guided-logic survey was developed based on review of primary literature regarding insulin pen utilization and evaluated by a panel of medication safety experts from a variety of health care settings...
December 2016: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28257919/progressing-moodswings-the-upgrade-and-evaluation-of-moodswings-2-0-an-online-intervention-for-bipolar-disorder
#16
S Lauder, V E Cosgrove, E Gliddon, D Grimm, S Dodd, L Berk, D Castle, T S Suppes, M Berk
MoodSwings 2.0 is a self-guided online intervention for bipolar disorder. The intervention incorporates technological improvements on an earlier validated version of the intervention (MoodSwings 1.0). The previous MoodSwings trial provides this study with a unique opportunity to progress previous work, whilst being able to take into consideration lesson learnt, and technological enhancements. The structure and technology of MoodSwings 2.0 are described and the relevance to other online health interventions is highlighted...
February 28, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28256829/computational-approach-to-structural-alerts-furans-phenols-nitroaromatics-and-thiophenes
#17
Na Le Dang, Tyler B Hughes, Grover P Miller, S Joshua Swamidass
Structural alerts are commonly used in drug discovery to identify molecules likely to form reactive metabolites and thereby become toxic. Unfortunately, as useful as structural alerts are, they do not effectively model if, when, and why metabolism renders safe molecules toxic. Toxicity due to a specific structural alert is highly conditional, depending on the metabolism of the alert, the reactivity of its metabolites, dosage, and competing detoxification pathways. A systems approach, which explicitly models these pathways, could more effectively assess the toxicity risk of drug candidates...
April 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28254350/the-current-status-of-artisanal-cannabis-for-the-treatment-of-epilepsy-in-the-united-states
#18
Dustin Sulak, Russell Saneto, Bonni Goldstein
The widespread patient use of artisanal cannabis preparations has preceded quality validation of cannabis use for epilepsy. Neurologists and cannabinoid specialists are increasingly in a position to monitor and guide the use of herbal cannabis in epilepsy patients. We report the retrospective data on efficacy and adverse effects of artisanal cannabis in Patients with medically refractory epilepsy with mixed etiologies in Washington State, California, and Maine. Clinical considerations, including potential risks and benefits, challenges related to artisanal preparations, and cannabinoid dosing, are discussed...
February 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28240694/improving-clinical-outcomes-for-patients-with-class-iii-heart-failure
#19
Melissa Shapiro, Angela Macci Bires, Kristen Waterstram-Rich, Thomas W Cline
Heart failure (HF) is a serious medical problem in the United States and is placing a financial strain on the health care system. It is the leading cause of mortality and as the overall incidence continues to increase, so does the economic impact on the health care system. Innovative treatment options, in the form of disease management programs and implantable cardiac devices, such as the CorVue capable implantable cardioverter defibrillator (ICD) pacemaker, offer the promise of an enhanced quality of life and reduced mortality...
April 2017: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/28152907/developing-and-implementing-emr-functionality-to-improve-oral-chemotherapy-outcomes
#20
Bruce Brockstein, George W Carro, Ashton Marie Hullett, Brad Hughes, Wayne Spath, Sharon Huginnie
159 Background: Approval of new oral anticancer agents (OAA) continues to rise, accounting for 75% of new oncology drugs approved so far in 2015. OAA prescriptions generated at our institution demonstrate similar growth, as the prescription volume for OAA is approximately 200% greater than it was 8 years ago. Challenges of OAA, including safe prescribing, monitoring toxicities, and assessing adherence, continue to be an obstacle to providing quality care. In recognition of these challenges, our institution employed the electronic medical record (EMR) to develop tools to enhance safe prescribing, monitoring, and follow up for patients receiving OAA...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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