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btb and cnc homology 1

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https://www.readbyqxmd.com/read/28142143/nrf2-and-bach1-may-play-a-role-in-the-modulation-of-ultraviolet-a-induced-oxidative-stress-by-acetyl-11-keto-%C3%AE-boswellic-acid-in-skin-keratinocytes
#1
Shiying Yang, Bin Zhou, Wei Xu, Fangfang Xue, Muhammad Farrukh Nisar, Chunxiang Bian, Xiao Huang, Li Yang, Yiguo Zhang, Jörg W Bartsch, Julia Li Zhong
BACKGROUND: Exposure of human skin to solar ultraviolet A (UVA) irradiation causes severe oxidative stress with damage to various cellular components and concomitant inflammation and carcinogenesis. OBJECTIVE: The aim of this study is to investigate the protective effect of acetyl-11-keto-β-boswellic acid (AKBA) against UVA radiation on human skin keratinocytes. METHODS: HaCaT cells were pretreated with AKBA followed by UVA irradiation. Radiation effects on cell morphology, cell viability, intracellular reactive oxygen species (ROS) levels, and antioxidant enzymes were examined...
February 1, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28123399/the-status-of-nrf2-based-therapeutics-current-perspectives-and-future-prospects
#2
REVIEW
Irina G Gazaryan, Bobby Thomas
This mini-review presents the authors' vision on the current status and future trends in the development of neuroprotective agents working via activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and in particular, via disruption of Nrf2-Keap1 interaction. There are two opposite "chemical" mechanisms underlying such activation: the first one is a non-specific covalent modification of Keap1 thiols, resulting in side effects of varied severity, and the second one is the shift of the Nrf2-Kelch-like ECH associated protein-1 (Keap1) binding equilibrium in the presence of a competitive and chemically benign displacement agent...
November 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28108387/inhibition-of-monoamine-oxidase-b-by-selegiline-reduces-cigarette-smoke-induced-oxidative-stress-and-inflammation-in-airway-epithelial-cells
#3
Yuting Cui, Kenneth W K Liu, Yingmin Liang, Mary S M Ip, Judith C W Mak
Chronic obstructive pulmonary disease (COPD) is caused by the build-up of oxidative stress-induced damages due to cigarette smoking, but how monoamine oxidase (MAO)-B signaling is involved remains unclear. This study aims to establish the involvement of MAO-B signaling pathways in cigarette smoke medium (CSM)-induced oxidative stress and inflammation in human airway epithelial cells (AECs). CSM treatment increased MAO-B activity, ROS levels and IL-8 release in AECs. Pretreatment with MAO-B selective inhibitor selegiline reversed the CSM-induced changes in MAO-B activity, ROS levels and IL-8 release in a dose-dependent manner...
February 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28099425/genetic-ablation-of-bach1-gene-enhances-recovery-from-hyperoxic-lung-injury-in-newborn-mice-via-transient-upregulation-of-inflammatory-genes
#4
Masato Ito, Nobuhiko Nagano, Yukio Arai, Ryo Ogawa, Shingo Kobayashi, Yukiko Motojima, Hayato Go, Masanori Tamura, Kazuhiko Igarashi, Phyllis A Dennery, Fumihiko Namba
BACKGROUND: BTB and CNC homology 1 (Bach1) is a transcriptional repressor of heme oxygenase (HO)-1. The effects of Bach1 disruption on hyperoxic lung injury in newborn mice have not been determined. We aimed to investigate the role of Bach1 in the newborns exposed to hyperoxia. METHODS: Bach1(-/-) and WT newborn mice were exposed to 21% or 95% oxygen for 4 days and were then allowed to recover in room air. Lung histology was assessed and lung Bach1, HO-1, IL-6, and monocyte chemoattractant protein (MCP)-1 mRNA levels were evaluated using RT-PCR...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28064106/neuroprotective-effects-of-erythropoietin-against-sevoflurane-induced-neuronal-apoptosis-in-primary-rat-cortical-neurons-involving-the-epor-erk1-2-nrf2-bach1-signal-pathway
#5
Dong-Xue Zhang, Li-Min Zhang, Xiao-Chun Zhao, Wenbo Sun
OBJECTIVE: Erythropoietin (EPO)-induced activation of the EPO receptor (EPOR) against sevoflurane-induced neuronal apoptosis is an effective intervention, but the underlying mechanism is poorly understood. Previous studies have shown that alteration of the nuclear factor erythroid 2-related factor (Nrf2)/BTB-to-CNC homology 1 (Bach1) ratio by extracellular signal-related kinases (Erk) 1/2 ameliorates the oxidative stress which occurs in human macrophages. In this study, we determined whether or not EPO attenuates sevoflurane-induced neuronal apoptosis via the EPOR-Erk1/2-Nrf2/Bach1 signal pathway...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28030830/ikaros-regulation-of-the-bcl6-bach2-axis-and-its-clinical-relevance-in-acute-lymphoblastic-leukemia
#6
Zheng Ge, Xilian Zhou, Yan Gu, Qi Han, Jianyong Li, Baoan Chen, Qinyu Ge, Elanora Dovat, Jonathon L Payne, Tianyu Sun, Chunhua Song, Sinisa Dovat
B-Cell CLL/Lymphoma 6 (BCL6) is a proto-oncogene that is highly expressed in acute lymphoblastic leukemia (ALL). BTB and CNC Homology 1 Basic Leucine Zipper Transcription Factor 2 (BACH2) is a suppressor of transcription. The BACH2-BCL6 balance controls selection at the pre-B cell receptor checkpoint by regulating p53 expression. However, the underlying mechanism and the clinical relevance of the BCL6/BACH2 axis are unknown. Here, we found that Ikaros, a tumor suppressor encoded by IKZF1, directly binds to both the BCL6 and BACH2 promoters where it suppresses BCL6 and promotes BACH2 expression in B-cell ALL (B-ALL) cells...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27999449/the-ratio-of-hmox1-nrf2-mrna-level-in-the-tumor-tissue-is-a-predictor-of-distant-metastasis-in-colorectal-cancer
#7
Liang-Che Chang, Chung-Wei Fan, Wen-Ko Tseng, Hui-Ping Chein, Tsan-Yu Hsieh, Jim-Ray Chen, Cheng-Cheng Hwang, Chung-Ching Hua
Heme oxygenase 1 (Hmox1) plays an important role in the growth and spread of tumor, and its expression is regulated positively by Nrf2 [nuclear factor (erythroid-derived 2)-like 2; NFE2L2] and negatively by kelch-like ECH-associated protein 1 (Keap1) and by BTB and CNC homology 1 (Bach1). Both Hmox1 and Nrf2 contribute to distant metastasis of cancer. The mRNA levels of Hmox1, Nrf2, Keap1, and Bach1 in the tumor and normal tissues of 84 subjects with colorectal cancer (CRC) were determined by real-time polymerase chain reaction...
2016: Disease Markers
https://www.readbyqxmd.com/read/27836987/rankl-induces-bach1-nuclear-import-and-attenuates-nrf2-mediated-antioxidant-enzymes-thereby-augmenting-intracellular-reactive-oxygen-species-signaling-and-osteoclastogenesis-in-mice
#8
Hiroyuki Kanzaki, Fumiaki Shinohara, Kanako Itohiya, Yuuki Yamaguchi, Yuta Katsumata, Masazumi Matsuzawa, Sari Fukaya, Yutaka Miyamoto, Satoshi Wada, Yoshiki Nakamura
Reactive oxygen species (ROS) play a role in intracellular signaling during osteoclastogenesis. We previously reported that transcriptional factor nuclear factor E2-related factor 2 (Nrf2) was exported from the nucleus to the cytoplasm by receptor activator of nuclear factor-κB ligand (RANKL), and that Nrf2 negatively regulated osteoclastogenesis via antioxidant enzyme up-regulation. Knockout mice of BTB and CNC homology 1 (Bach1)-the competitor for Nrf2 in transcriptional regulation-was known to attenuate RANKL-mediated osteoclastogenesis, although the mechanism remains unclear...
November 11, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27393035/tetrachlorobenzoquinone-induces-nrf2-activation-via-rapid-bach1-nuclear-export-ubiquitination-and-jnk-p62-signaling
#9
Chuanyang Su, Qiong Shi, Xiufang Song, Juanli Fu, Zixuan Liu, Yawen Wang, Yuxin Wang, Xiaomin Xia, Erqun Song, Yang Song
Our previous studies demonstrated that tetrachlorobenzoquinone (TCBQ), an active metabolite of pentachlorophenol, has effects on the generation of reactive oxygen species (ROS) and oxidative stress in vitro and in vivo. Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a cellular sensor of electrophilic or oxidative stress that regulates the expression of antioxidant enzymes and defensive proteins. We have illustrated that TCBQ activates Nrf2 signaling by promoting the formation of the Kelch-like ECH-associated protein 1 (Keap1) cross-linking dimer and the formation of an ubiquitination switch from Nrf2 to Keap1...
July 1, 2016: Toxicology
https://www.readbyqxmd.com/read/27108804/bach1-the-master-regulator-gene-a-novel-candidate-target-for-cancer-therapy
#10
REVIEW
Sadaf Davudian, Behzad Mansoori, Neda Shajari, Ali Mohammadi, Behzad Baradaran
BACH1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1) is a transcriptional factor and a member of cap 'n' collar (CNC) and basic region leucine zipper factor family. In contrast to other bZIP family members, BACH1 appeared as a comparatively specific transcription factor. It acts as transcription regulator and is recognized as a recently hypoxia regulator and functions as an inducible repressor for the HO-1 gene in many human cell types in response to stress oxidative. In regard to studies lately, although, BACH1 has been related to the regulation of oxidative stress and heme oxidation, it has never been linked to invasion and metastasis...
August 15, 2016: Gene
https://www.readbyqxmd.com/read/27057283/bach1-induces-endothelial-cell-apoptosis-and-cell-cycle-arrest-through-ros-generation
#11
Xinhong Wang, Junxu Liu, Li Jiang, Xiangxiang Wei, Cong Niu, Rui Wang, Jianyi Zhang, Dan Meng, Kang Yao
The transcription factor BTB and CNC homology 1 (Bach1) regulates genes involved in the oxidative stress response and cell-cycle progression. We have recently shown that Bach1 impairs cell proliferation and promotes apoptosis in cultured endothelial cells (ECs), but the underlying mechanisms are largely uncharacterized. Here we demonstrate that Bach1 upregulation impaired the blood flow recovery from hindlimb ischemia and this effect was accompanied both by increases in reactive oxygen species (ROS) and cleaved caspase 3 levels and by declines in the expression of cyclin D1 in the injured tissues...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27030212/genomewide-approaches-for-bach1-target-genes-in-mouse-embryonic-fibroblasts-showed-bach1-pparg-pathway-in-adipogenesis
#12
Mitsuyo Matsumoto, Keiichi Kondo, Takuma Shiraki, Andrey Brydun, Ryo Funayama, Keiko Nakayama, Nobuo Yaegashi, Hideki Katagiri, Kazuhiko Igarashi
The transcription repressor BTB and CNC homology 1 (BACH1) represses genes involved in heme metabolism and oxidative stress response. BACH1 also suppresses the p53-dependent cellar senescence in primary mouse embryonic fibroblasts (MEFs). To investigate the role of BACH1 in MEF other than its known functions, we carried out a genomewide mapping of binding site for BACH1 and its heterodimer partner MAFK in immortalized MEFs (iMEFs) using chromatin immunoprecipitation and next-generation sequencing technology (ChIP-sequence)...
June 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/26907258/assessment-of-radiation-induced-therapeutic-effect-and-cytotoxicity-in-cancer-patients-based-on-transcriptomic-profiling
#13
Sajjad Karim, Zeenat Mirza, Adeel G Chaudhary, Adel M Abuzenadah, Mamdooh Gari, Mohammed H Al-Qahtani
Toxicity induced by radiation therapy is a curse for cancer patients undergoing treatment. It is imperative to understand and define an ideal condition where the positive effects notably outweigh the negative. We used a microarray meta-analysis approach to measure global gene-expression before and after radiation exposure. Bioinformatic tools were used for pathways, network, gene ontology and toxicity related studies. We found 429 differentially expressed genes at fold change >2 and p-value <0.05. The most significantly upregulated genes were synuclein alpha (SNCA), carbonic anhydrase I (CA1), X-linked Kx blood group (XK), glycophorin A and B (GYPA and GYPB), and hemogen (HEMGN), while downregulated ones were membrane-spanning 4-domains, subfamily A member 1 (MS4A1), immunoglobulin heavy constant mu (IGHM), chemokine (C-C motif) receptor 7 (CCR7), BTB and CNC homology 1 transcription factor 2 (BACH2), and B-cell CLL/lymphoma 11B (BCL11B)...
February 19, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26811478/transketolase-counteracts-oxidative-stress-to-drive-cancer-development
#14
Iris Ming-Jing Xu, Robin Kit-Ho Lai, Shu-Hai Lin, Aki Pui-Wah Tse, David Kung-Chun Chiu, Hui-Yu Koh, Cheuk-Ting Law, Chun-Ming Wong, Zongwei Cai, Carmen Chak-Lui Wong, Irene Oi-Lin Ng
Cancer cells experience an increase in oxidative stress. The pentose phosphate pathway (PPP) is a major biochemical pathway that generates antioxidant NADPH. Here, we show that transketolase (TKT), an enzyme in the PPP, is required for cancer growth because of its ability to affect the production of NAPDH to counteract oxidative stress. We show that TKT expression is tightly regulated by the Nuclear Factor, Erythroid 2-Like 2 (NRF2)/Kelch-Like ECH-Associated Protein 1 (KEAP1)/BTB and CNC Homolog 1 (BACH1) oxidative stress sensor pathway in cancers...
February 9, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26787892/common-braf-v600e-directed-pathway-mediates-widespread-epigenetic-silencing-in-colorectal-cancer-and-melanoma
#15
Minggang Fang, Lloyd Hutchinson, April Deng, Michael R Green
During cancer development, it is well established that many genes, including tumor suppressor genes, are hypermethylated and transcriptionally repressed, a phenomenon referred to as epigenetic silencing. In general, the factors involved in, and the mechanistic basis of, epigenetic silencing during cancer development are not well understood. We have recently described an epigenetic silencing pathway, directed by the oncogenic B-Raf proto-oncogene (BRAF) variant BRAF(V600E), that mediates widespread epigenetic silencing in colorectal cancer (CRC)...
February 2, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26458773/bach1-deficiency-reduces-severity-of-osteoarthritis-through-upregulation-of-heme-oxygenase-1
#16
Tsuyoshi Takada, Shigeru Miyaki, Hiroyuki Ishitobi, Yuya Hirai, Tomoyuki Nakasa, Kazuhiko Igarashi, Martin K Lotz, Mitsuo Ochi
INTRODUCTION: BTB and CNC homology 1 (Bach1) is a transcriptional repressor of Heme oxygenase-1 (HO-1), which is cytoprotective through its antioxidant effects. The objective of this study was to define the role of Bach1 in cartilage homeostasis and osteoarthritis (OA) development using in vitro models and Bach1 (-/-) mice. METHODS: HO-1 expression in Bach1 (-/-) mice was analyzed by real-time PCR, immunohistochemistry and immunoblotting. Knee joints from Bach1 (-/-) and wild-type mice with age-related OA and surgically-induced OA were evaluated by OA scoring systems...
October 13, 2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/26377036/correlation-of-bach1-and-hemoglobin-e-beta-thalassemia-globin-expression
#17
Tze Yan Lee, Logeswaran Muniandy, Lai Kuan Teh, Maha Abdullah, Elizabeth George, Jameela Sathar, Mei I Lai
OBJECTIVE: The diverse clinical phenotype of hemoglobin E (HbE)/β-thalassemia has not only confounded clinicians in matters of patient management but has also led scientists to investigate the complex mechanisms involved in maintaining the delicate red cell environment where, even with apparent similarities of α- and β-globin genotypes, the phenotype tells a different story. The BTB and CNC homology 1 (BACH1) protein is known to regulate α- and β-globin gene transcriptions during the terminal differentiation of erythroid cells...
March 5, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/26244607/dual-regulation-of-skin-sensitizer-induced-hmox1-expression-by-bach1-and-nrf2-comparison-to-regulation-of-the-akr1c2-are-element-in-the-keratinosens-cell-line
#18
Roger Emter, Andreas Natsch
Heme oxygenase (decycling) 1 (HMOX1) is the most consistently found genetic marker induced by skin sensitizers. HMOX1 is often referred to as typical gene regulated by nuclear factor erythroid 2-related factor 2 (Nrf2), however, it is also regulated by other DNA-binding factors, including BTB and CNC homolog 1 (Bach1). The KeratinoSens™ assay is the first validated in vitro assay for sensitizers that measures gene induction. It is based on luciferase expression regulated by the antioxidant response element (ARE) of the aldoketoreductase 1C2 (AKR1C2) gene...
November 1, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26094714/paired-box-gene-5-isoforms-a-and-b-have-different-functions-in-transcriptional-regulation-of-b-cell-development-related-genes-in-immature-b-cells
#19
Hidehiko Kikuchi, Masami Nakayama, Futoshi Kuribayashi, Hitomi Mimuro, Shinobu Imajoh-Ohmi, Hideki Nishitoh, Yasunari Takami, Tatsuo Nakayama
The transcription factor paired box gene 5 (Pax5) is essential for B cell development. In this study, complementation analyses in Pax5-deficient DT40 cells showed that three Pax5 isoforms Pax5A, Pax5B and Pax5BΔEx8 (another spliced isoform of Pax5B lacking exon 8) exhibit distinct roles in transcriptional regulation of six B cell development-related genes (activation-induced cytidine deaminase, Aiolos, BTB and CNC homology 2, B cell lymphoma-6, early B cell factor 1, origin binding factor-1 genes), transcriptions of which are remarkably down-regulated by Pax5-deficiency...
July 2015: Microbiology and Immunology
https://www.readbyqxmd.com/read/25624468/functional-capacities-of-human-igm-memory-b-cells-in-early-inflammatory-responses-and-secondary-germinal-center-reactions
#20
Marc Seifert, Martina Przekopowitz, Sarah Taudien, Anna Lollies, Viola Ronge, Britta Drees, Monika Lindemann, Uwe Hillen, Harald Engler, Bernhard B Singer, Ralf Küppers
The generation and functions of human peripheral blood (PB) IgM(+)IgD(+)CD27(+) B lymphocytes with somatically mutated IgV genes are controversially discussed. We determined their differential gene expression to naive B cells and to IgM-only and IgG(+) memory B cells. This analysis revealed a high similarity of IgM(+)(IgD(+))CD27(+) and IgG(+) memory B cells but also pointed at distinct functional capacities of both subsets. In vitro analyses revealed a tendency of activated IgM(+)IgD(+)CD27(+) B cells to migrate to B-cell follicles and undergo germinal center (GC) B-cell differentiation, whereas activated IgG(+) memory B cells preferentially showed a plasma cell (PC) fate...
February 10, 2015: Proceedings of the National Academy of Sciences of the United States of America
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