keyword
MENU ▼
Read by QxMD icon Read
search

BACH1

keyword
https://www.readbyqxmd.com/read/28213091/convergence-of-hepcidin-deficiency-systemic-iron-overloading-heme-accumulation-and-rev-erb%C3%AE-%C3%AE-activation-in-aryl-hydrocarbon-receptor-elicited-hepatotoxicity
#1
Kelly A Fader, Rance Nault, Mathew P Kirby, Gena Markous, Jason Matthews, Timothy R Zacharewski
Persistent aryl hydrocarbon receptor (AhR) agonists elicit dose-dependent hepatic lipid accumulation, oxidative stress, inflammation, and fibrosis in mice. Iron (Fe) promotes AhR-mediated oxidative stress by catalyzing reactive oxygen species (ROS) production. To further characterize the role of Fe in AhR-mediated hepatotoxicity, male C57BL/6 mice were orally gavaged with sesame oil vehicle or 0.01-30μg/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) every 4days for 28days. Duodenal epithelial and hepatic RNA-Seq data were integrated with hepatic AhR ChIP-Seq, capillary electrophoresis protein measurements, and clinical chemistry analyses...
February 16, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28142143/nrf2-and-bach1-may-play-a-role-in-the-modulation-of-ultraviolet-a-induced-oxidative-stress-by-acetyl-11-keto-%C3%AE-boswellic-acid-in-skin-keratinocytes
#2
Shiying Yang, Bin Zhou, Wei Xu, Fangfang Xue, Muhammad Farrukh Nisar, Chunxiang Bian, Xiao Huang, Li Yang, Yiguo Zhang, Jörg W Bartsch, Julia Li Zhong
BACKGROUND: Exposure of human skin to solar ultraviolet A (UVA) irradiation causes severe oxidative stress with damage to various cellular components and concomitant inflammation and carcinogenesis. OBJECTIVE: The aim of this study is to investigate the protective effect of acetyl-11-keto-β-boswellic acid (AKBA) against UVA radiation on human skin keratinocytes. METHODS: HaCaT cells were pretreated with AKBA followed by UVA irradiation. Radiation effects on cell morphology, cell viability, intracellular reactive oxygen species (ROS) levels, and antioxidant enzymes were examined...
February 1, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28123399/the-status-of-nrf2-based-therapeutics-current-perspectives-and-future-prospects
#3
REVIEW
Irina G Gazaryan, Bobby Thomas
This mini-review presents the authors' vision on the current status and future trends in the development of neuroprotective agents working via activation of nuclear factor erythroid 2-related factor 2 (Nrf2), and in particular, via disruption of Nrf2-Keap1 interaction. There are two opposite "chemical" mechanisms underlying such activation: the first one is a non-specific covalent modification of Keap1 thiols, resulting in side effects of varied severity, and the second one is the shift of the Nrf2-Kelch-like ECH associated protein-1 (Keap1) binding equilibrium in the presence of a competitive and chemically benign displacement agent...
November 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28120861/intracellular-degradation-of-functionalized-carbon-nanotube-iron-oxide-hybrids-is-modulated-by-iron-via-nrf2-pathway
#4
Dan Elgrabli, Walid Dachraoui, Hélène de Marmier, Cécilia Ménard-Moyon, Dominique Bégin, Sylvie Bégin-Colin, Alberto Bianco, Damien Alloyeau, Florence Gazeau
The in vivo fate and biodegradability of carbon nanotubes is still a matter of debate despite tremendous applications. In this paper we describe a molecular pathway by which macrophages degrade functionalized multi-walled carbon nanotubes (CNTs) designed for biomedical applications and containing, or not, iron oxide nanoparticles in their inner cavity. Electron microscopy and Raman spectroscopy show that intracellularly-induced structural damages appear more rapidly for iron-free CNTs in comparison to iron-loaded ones, suggesting a role of iron in the degradation mechanism...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28108387/inhibition-of-monoamine-oxidase-b-by-selegiline-reduces-cigarette-smoke-induced-oxidative-stress-and-inflammation-in-airway-epithelial-cells
#5
Yuting Cui, Kenneth W K Liu, Yingmin Liang, Mary S M Ip, Judith C W Mak
Chronic obstructive pulmonary disease (COPD) is caused by the build-up of oxidative stress-induced damages due to cigarette smoking, but how monoamine oxidase (MAO)-B signaling is involved remains unclear. This study aims to establish the involvement of MAO-B signaling pathways in cigarette smoke medium (CSM)-induced oxidative stress and inflammation in human airway epithelial cells (AECs). CSM treatment increased MAO-B activity, ROS levels and IL-8 release in AECs. Pretreatment with MAO-B selective inhibitor selegiline reversed the CSM-induced changes in MAO-B activity, ROS levels and IL-8 release in a dose-dependent manner...
February 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28099425/genetic-ablation-of-bach1-gene-enhances-recovery-from-hyperoxic-lung-injury-in-newborn-mice-via-transient-upregulation-of-inflammatory-genes
#6
Masato Ito, Nobuhiko Nagano, Yukio Arai, Ryo Ogawa, Shingo Kobayashi, Yukiko Motojima, Hayato Go, Masanori Tamura, Kazuhiko Igarashi, Phyllis A Dennery, Fumihiko Namba
BACKGROUND: BTB and CNC homology 1 (Bach1) is a transcriptional repressor of heme oxygenase (HO)-1. The effects of Bach1 disruption on hyperoxic lung injury in newborn mice have not been determined. We aimed to investigate the role of Bach1 in the newborns exposed to hyperoxia. METHODS: Bach1(-/-) and WT newborn mice were exposed to 21% or 95% oxygen for 4 days and were then allowed to recover in room air. Lung histology was assessed and lung Bach1, HO-1, IL-6, and monocyte chemoattractant protein (MCP)-1 mRNA levels were evaluated using RT-PCR...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28092843/therapeutic-effects-of-bach1-sirna-on-human-breast-adenocarcinoma-cell-line
#7
Mansoor Aletaha, Behzad Mansoori, Ali Mohammadi, Mehdi Fazeli, Behzad Baradaran
BACKGROUND: Despite the great improvements in clinical and therapeutic techniques in recent years, many advanced breast cancer patients still died of the postoperative recurrence and metastasis of disease. Bach1 plays a role in the development of the invasive phenotypes of cancer, cell division and apoptosis in tumor cells. The aim of this study was to investigate the effect of specific bach1 siRNAs, on the proliferation, migration, invasive, induction of apoptosis, cell cycle arrest and alter EMT related miRNA of MDA-MB-468 cells (breast cancer)...
January 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28065629/the-effects-of-emodin-on-cell-viability-respiratory-burst-and-gene-expression-of-nrf2-keap1-signaling-molecules-in-the-peripheral-blood-leukocytes-of-blunt-snout-bream-megalobrama-amblycephala
#8
Zhenxin Zhao, Jun Xie, Bo Liu, Xianping Ge, Changyou Song, Mingchun Ren, Qunlan Zhou, Linghong Miao, Huimin Zhang, Fan Shan, Zhenfei Yang
We determined the effects of emodin on the cell viability, respiratory burst activity, mRNA levels of antioxidative enzymes (Cu-Zn SOD, CAT and NOX2), and gene expressions of the Nrf2-Keap1 signaling molecules in the peripheral blood leukocytes of blunt snout bream. Triplicate groups of cultured cells were treated with different concentrations of emodin (0.04-25 μg/ml) for 24 h. Results showed that the emodin caused a dramatic loss in cell viability, and occurred in a dose-dependent manner. Emodin exposure (1-25 μg/ml) were significantly induced the ROS generation compared to the control...
January 5, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28064106/neuroprotective-effects-of-erythropoietin-against-sevoflurane-induced-neuronal-apoptosis-in-primary-rat-cortical-neurons-involving-the-epor-erk1-2-nrf2-bach1-signal-pathway
#9
Dong-Xue Zhang, Li-Min Zhang, Xiao-Chun Zhao, Wenbo Sun
OBJECTIVE: Erythropoietin (EPO)-induced activation of the EPO receptor (EPOR) against sevoflurane-induced neuronal apoptosis is an effective intervention, but the underlying mechanism is poorly understood. Previous studies have shown that alteration of the nuclear factor erythroid 2-related factor (Nrf2)/BTB-to-CNC homology 1 (Bach1) ratio by extracellular signal-related kinases (Erk) 1/2 ameliorates the oxidative stress which occurs in human macrophages. In this study, we determined whether or not EPO attenuates sevoflurane-induced neuronal apoptosis via the EPOR-Erk1/2-Nrf2/Bach1 signal pathway...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28000777/bach1-promotes-temozolomide-resistance-in-glioblastoma-through-antagonizing-the-function-of-p53
#10
Er Nie, Xin Jin, Weining Wu, Tianfu Yu, Xu Zhou, Tongle Zhi, Zhumei Shi, Junxia Zhang, Ning Liu, Yongping You
The acquisition of drug resistance is a persistent clinical problem limiting the successful treatment of glioblastoma (GBM). However, the molecular mechanisms by which initially chemoresponsive tumors develop therapeutic resistance remain poorly understood. In this study, we report that BACH1, a heme-binding protein that participates in transcriptional repression or activation, was significantly upregulated in glioblastoma tissues. Overexpression of BACH1 in GBM cells conferred resistance to temozolomide, whereas its inhibition markedly sensitized resistant cells to temozolomide in vitro and in vivo...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27999449/the-ratio-of-hmox1-nrf2-mrna-level-in-the-tumor-tissue-is-a-predictor-of-distant-metastasis-in-colorectal-cancer
#11
Liang-Che Chang, Chung-Wei Fan, Wen-Ko Tseng, Hui-Ping Chein, Tsan-Yu Hsieh, Jim-Ray Chen, Cheng-Cheng Hwang, Chung-Ching Hua
Heme oxygenase 1 (Hmox1) plays an important role in the growth and spread of tumor, and its expression is regulated positively by Nrf2 [nuclear factor (erythroid-derived 2)-like 2; NFE2L2] and negatively by kelch-like ECH-associated protein 1 (Keap1) and by BTB and CNC homology 1 (Bach1). Both Hmox1 and Nrf2 contribute to distant metastasis of cancer. The mRNA levels of Hmox1, Nrf2, Keap1, and Bach1 in the tumor and normal tissues of 84 subjects with colorectal cancer (CRC) were determined by real-time polymerase chain reaction...
2016: Disease Markers
https://www.readbyqxmd.com/read/27993883/association-of-reduced-heme-oxygenase-1-with-decreased-microrna-196a2-expression-in-peripheral-blood-mononuclear-cells-of-patients-with-intestinal-behcet-s-disease
#12
Jun Zou, Da-Nian Ji, Yan Shen, Jian-Long Guan, Song-Bai Zheng
AIMS: To examine the expression of miRNAs and mRNAs of heme oxygenase 1 (HO-1) in patients with active intestinal Behcet's disease (BD). METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from BD patients with active ileocecal ulcers or from healthy donors. Expression levels of four miRNAs were studied using real-time PCR. The levels of mRNAs of ho-1, bach1, and CD14 were measured by qRT-PCR. Serum levels of cytokines were analyzed by ELISA. RESULTS: Among four miRNAs, only levels of miR-196a2 were significantly decreased from BD patients with active ileocecal ulcers as compared with healthy controls...
December 2016: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/27959382/bach1-sirna-attenuates-bleomycin-induced-pulmonary-fibrosis-by-modulating-oxidative-stress-in-mice
#13
Yuan Liu, Yi Zheng
Oxidative stress plays an essential role in inflammation and fibrosis. Bach1 is an important transcriptional repressor that acts by modulating oxidative stress and represents a potential target in the treatment of pulmonary fibrosis (PF). In this study, we knocked down Bach1 using adenovirus-mediated small interfering RNA (siRNA) to determine whether the use of Bach1 siRNA is an effective therapeutic strategy in mice with bleomycin (BLM)‑induced PF. Mouse lung fibroblasts (MLFs) were incubated with transforming growth factor (TGF)-β1 (5 ng/ml) and subsequently infected with recombined adenovirus-like Bach1 siRNA1 and Bach1 siRNA2, while an empty adenovirus vector was used as the negative control...
January 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27927768/iron-heme-bach1-axis-is-involved-in-erythroblast-adaptation-to-iron-deficiency
#14
Masahiro Kobayashi, Hiroki Kato, Hiroshi Hada, Ari Itoh-Nakadai, Tohru Fujiwara, Akihiko Muto, Yukihiro Inoguchi, Kenji Ichiyanagi, Wataru Houjou, Naohisa Tomosugi, Hiroyuki Sasaki, Hideo Harigae, Kazuhiko Igarashi
Iron plays the central role in the oxygen transport by the erythrocyte as a constituent of heme and hemoglobin. The importance of iron and heme also resides in their regulatory roles during erythroblast maturation. The transcription factor Bach1 may be involved in their regulatory roles since it is inactivated by direct binding of heme. To address whether Bach1 is involved in the responses of erythroblasts to iron status, low iron conditions that induced severe iron deficiency in mice were established. Under iron deficiency, extensive gene expression changes and mitophagy disorder were induced during maturation of erythroblasts...
December 7, 2016: Haematologica
https://www.readbyqxmd.com/read/27878758/gender-specific-expression-of-ubiquitin-specific-peptidase-9-modulates-tau-expression-and-phosphorylation-possible-implications-for-tauopathies
#15
Sandra Köglsberger, Maria Lorena Cordero-Maldonado, Paul Antony, Julia Ilona Forster, Pierre Garcia, Manuel Buttini, Alexander Crawford, Enrico Glaab
Public transcriptomic studies have shown that several genes display pronounced gender differences in their expression in the human brain, which may influence the manifestations and risk for neuronal disorders. Here, we apply a transcriptome-wide analysis to discover genes with gender-specific expression and significant alterations in public postmortem brain tissue from Alzheimer's disease (AD) patients compared to controls. We identify the sex-linked ubiquitin-specific peptidase 9 (USP9) as an outstanding candidate gene with highly significant expression differences between the genders and male-specific underexpression in AD...
November 23, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27836987/rankl-induces-bach1-nuclear-import-and-attenuates-nrf2-mediated-antioxidant-enzymes-thereby-augmenting-intracellular-reactive-oxygen-species-signaling-and-osteoclastogenesis-in-mice
#16
Hiroyuki Kanzaki, Fumiaki Shinohara, Kanako Itohiya, Yuuki Yamaguchi, Yuta Katsumata, Masazumi Matsuzawa, Sari Fukaya, Yutaka Miyamoto, Satoshi Wada, Yoshiki Nakamura
Reactive oxygen species (ROS) play a role in intracellular signaling during osteoclastogenesis. We previously reported that transcriptional factor nuclear factor E2-related factor 2 (Nrf2) was exported from the nucleus to the cytoplasm by receptor activator of nuclear factor-κB ligand (RANKL), and that Nrf2 negatively regulated osteoclastogenesis via antioxidant enzyme up-regulation. Knockout mice of BTB and CNC homology 1 (Bach1)-the competitor for Nrf2 in transcriptional regulation-was known to attenuate RANKL-mediated osteoclastogenesis, although the mechanism remains unclear...
November 11, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27817989/heme-oxygenase-1-affects-granulopoiesis-in-mice-through-control-of-myelocyte-proliferation
#17
Karolina Bukowska-Strakova, Maciej Ciesla, Krzysztof Szade, Witold Norbert Nowak, Robert Straka, Agata Szade, Malgorzata Tyszka-Czochara, Karolina Najder, Anna Konturek, Maciej Siedlar, Jozef Dulak, Alicja Jozkowicz
Heme oxygenase-1 (HO-1) is stress-inducible, cytoprotective enzyme degrading heme to carbon monoxide (CO), biliverdin and Fe(2+). We showed that HO-1 knock-out mice (HO-1(-/-)) have a twofold higher level of granulocytes than wild type (WT) mice, despite decreased concentration of granulocyte colony-stimulating factor (G-CSF) in the blood and reduced surface expression of G-CSF receptor on the hematopoietic precursors. This suggests the effect of HO-1 on granulopoiesis. Here we aimed to determine the stage of granulopoiesis regulated by HO-1...
October 21, 2016: Immunobiology
https://www.readbyqxmd.com/read/27721085/signaling-pathways-involved-in-hsp32-induction-by-hyperbaric-oxygen-in-rat-spinal-neurons
#18
Guoyang Huang, Jiale Diao, Hongjie Yi, Li Xu, Jiajun Xu, Weigang Xu
Spinal cord injury (SCI) is a debilitating disease, effective prevention measures are in desperate need. Our previous work found that hyperbaric oxygen (HBO) preconditioning significantly protected rats from SCI after stimulated diving, and in vitro study further testified that HBO protected primary cultured rat spinal neurons from oxidative insult and oxygen glucose deprivation injury via heat shock protein (HSP) 32 induction. In this study, underlying molecular mechanisms were further investigated. The results showed that a single exposure to HBO significantly increased intracellular levels of reactive oxygen species (ROS) and nitric oxide (NO) and activated MEK1/2, ERK1/2, p38 MAPK, CREB, Bach1 and Nrf2...
September 24, 2016: Redox Biology
https://www.readbyqxmd.com/read/27714264/topical-treatment-of-green-tea-polyphenols-emulsified-in-carboxymethyl-cellulose-protects-against-acute-ultraviolet-light-b-induced-photodamage-in-hairless-mice
#19
Huaping Li, Na Jiang, Qing Liu, Aili Gao, Xin Zhou, Bihua Liang, Runxiang Li, Zhenjie Li, Huilan Zhu
Ultraviolet (UV) radiation causes skin injury and inflammation resulting in impaired immune response and increased risk of skin cancer. It has been shown that green tea polyphenols (GTPs) enhanced intracellular antioxidant defense and promoted the downregulation of proapoptotic genes, and they could be used to protect against the damage induced by UV irradiation. However, the high instability and poor bioavailability of GTPs impose restrictions on their potential pharmacological use. Here we show that carboxymethyl cellulose sodium (CMC-Na) had a stabilizing effect on GTPs under aqueous conditions and topical application of GTPs (emulsified in CMC-Na) had a strong photoprotective effect against acute UVB induced photodamage in uncovered (Uncv) hairless mice skin...
October 5, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27427974/transcription-factor-nfe2l2-nrf2-is-a-regulator-of-macroautophagy-genes
#20
Marta Pajares, Natalia Jiménez-Moreno, Ángel J García-Yagüe, Maribel Escoll, María L de Ceballos, Fred Van Leuven, Alberto Rábano, Masayuki Yamamoto, Ana I Rojo, Antonio Cuadrado
Autophagy is a highly coordinated process that is controlled at several levels including transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear factor, erythroid 2 like 2) as a regulator of autophagy gene expression and its relevance in a mouse model of Alzheimer disease (AD) that reproduces impaired APP (amyloid β precursor protein) and human (Hs)MAPT/TAU processing, clearance and aggregation. We screened the chromatin immunoprecipitation database ENCODE for 2 proteins, MAFK and BACH1, that bind the NFE2L2-regulated enhancer antioxidant response element (ARE)...
October 2, 2016: Autophagy
keyword
keyword
100059
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"