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Spinal cord injury bladder

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https://www.readbyqxmd.com/read/29665503/zebrafish-extracellular-matrix-improves-neuronal-viability-and-network-formation-in-a-3-dimensional-culture
#1
Sung-Min Kim, Daniel Ward Long, Michael Wai Kok Tsang, Yadong Wang
Mammalian central nervous system (CNS) has limited capacity for regeneration. CNS injuries cause life-long debilitation and lead to $50 billion in healthcare costs in U.S. alone each year. Despite numerous efforts in the last few decades, CNS-related injuries remain as detrimental as they were 50 years ago. Some functional recovery can occur, but most regeneration are limited by an extracellular matrix (ECM) that actively inhibits axonal repair and promotes glial scarring. In most tissues, the ECM is an architectural foundation that plays an active role in supporting cellular development and regenerative response after injury...
April 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29664238/testing-of-a-new-portable-device-for-dynamic-bladder-pressure-monitoring
#2
Lingfeng Liu, Kang Zhao, Fan Chen, Jian Wu, Zhaofeng Yang, Ming Chen, Linbo Mao, Jiurong Han
OBJECTIVE: To develop a portable dynamic bladder pressure monitoring device for facilitating the monitoring of bladder detrusor pressure in patients with neurogenic bladder (NB) caused by spinal cord injury and further compared the effect with traditional urodynamics devices. METHODS: Portable dynamic bladder pressure monitoring device was implemented by software and hardware. The hardware was mainly composed of seven parts, such as micro liquid pressure sensor, electric bridge amplifying circuit, clock module, SD card storage circuit, liquid crystal display circuit, touch circuit, controller circuit and so on...
May 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29644100/persistent-urine-leakage-around-a-suprapubic-catheter-the-experience-of-a-person-with-chronic-tetraplegia
#3
Subramanian Vaidyanathan, Jerry Ward, Bakul M Soni, Peter Hughes, Tun Oo
Introduction: Persistent urine leakage after suprapubic cystostomy in tetraplegic subjects occurs due to shrinkage of the urinary bladder and bladder spasms. The patient's social life is adversely affected as clothes become wet, smelly, and require frequent changing, thus increasing the workload of carers. Case presentation: A 48-year-old male sustained C-4 complete (AIS:A) tetraplegia while swimming in 2007. Suprapubic cystostomy was performed in 2009. From 2012, this patient had urine leakage around the suprapubic catheter, which became progressively more frequent...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29627087/autonomic-nervous-system-in-paralympic-athletes-with-spinal-cord-injury
#4
REVIEW
Matthias Walter, Andrei V Krassioukov
Individuals sustaining a spinal cord injury (SCI) frequently suffer from sensorimotor and autonomic impairment. Damage to the autonomic nervous system results in cardiovascular, respiratory, bladder, bowel, and sexual dysfunctions, as well as temperature dysregulation. These complications not only impede quality of life, but also affect athletic performance of individuals with SCI. This article summarizes existing evidence on how damage to the spinal cord affects the autonomic nervous system and impacts the performance in athletes with SCI...
May 2018: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/29614704/constitutively-reduced-sensory-capacity-promotes-better-recovery-after-spinal-cord-injury-sci-in-blind-rats-of-the-dystrophic-rcs-strain
#5
Svenja Rink, Habib Bendella, Kurdin Alsolivany, Carolin Meyer, Aliona Woehler, Ramona Jansen, Zeynep Isik, Gregor Stein, Sina Wennmachers, Makoto Nakamura, Doychin N Angelov
BACKGROUND: We compared functional, electrophysiological and morphological parameters after SCI in two groups of rats Sprague Dawley (SD) rats with normal vision and blind rats from a SD-substrain "Royal College of Surgeons" (SD/RCS) who lose their photoreceptor cells after birth due to a genetic defect in the retinal pigment epithelium. For these animals skin-, intramuscular-, and tendon receptors are major available means to resolve spatial information. OBJECTIVE: The purpose of this study was to check whether increased sensitivity in SD/RCS rats would promote an improved recovery after SCI...
March 25, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29605828/current-and-future-international-patterns-of-care-of-neurogenic-bladder-after-spinal-cord-injury
#6
A Gomelsky, G E Lemack, J C Castano Botero, R K Lee, J B Myers, P Granitsiotis, R R Dmochowski
PURPOSE: We aim to summarize the literature on international patterns of care for patients with neurogenic bladder (NGB) from spinal cord injury (SCI). METHODS: We performed a PubMed database search, hand review of references, communication with professional societies, and registry evaluations for pertinent data. RESULTS: Established patterns of care, including SCI registries and specialty centers, are available in high-resource countries such as the US and UK...
March 31, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29603781/efficacy-and-safety-of-mirabegron-for-the-treatment-of-neurogenic-detrusor-overactivity-prospective-randomized-double-blind-placebo-controlled-study
#7
Jan Krhut, Vladimír Borovička, Karolína Bílková, Radek Sýkora, David Míka, Jan Mokriš, Roman Zachoval
AIMS: To assess the efficacy and safety of mirabegron in the treatment of neurogenic detrusor overactivity. METHODS: This prospective, multicenter, randomized, double-blind, placebo-controlled study was conducted in three tertiary centers, and included 78 patients suffering from spinal cord injury or multiple sclerosis. Patients were randomized for Mirabegron 50 mg (Group A) or placebo (Group B). Urodynamic parameters, the 24 h pad-weight test, and patient-reported outcomes were assessed...
March 31, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29603450/nerve-growth-factor-dependent-hyperexcitability-of-capsaicin-sensitive-bladder-afferent-neurones-in-mice-with-spinal-cord-injury
#8
Takahiro Shimizu, Tsuyoshi Majima, Takahisa Suzuki, Nobutaka Shimizu, Naoki Wada, Katsumi Kadekawa, Shun Takai, Eiichiro Takaoka, Joonbeom Kwon, Anthony J Kanai, William C de Groat, Pradeep Tyagi, Motoaki Saito, Naoki Yoshimura
Nerve growth factor (NGF) has been implicated as an important mediator to induce C-fibre bladder afferent hyperexcitability, which contributes to the emergence of neurogenic lower urinary tract dysfunction (LUTD) following spinal cord injury (SCI). In this study, we determined if NGF immunoneutralization using an anti-NGF antibody (NGF-Ab) normalizes the SCI-induced changes in electrophysiological properties of capsaicin-sensitive C-fibre bladder afferent neurones in female C57BL/6 mice. The spinal cord was transected at the Th8/9 level...
March 30, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29600402/bladder-management-during-pregnancy-in-women-with-spinal-cord-injury-an-observational-multicenter-study
#9
Elena Andretta, Lorenza Maria Landi, Mirella Cianfrocca, Alberto Manassero, Oreste Risi, Giorgio Artuso
INTRODUCTION AND HYPOTHESIS: Pregnancy in women with spinal-cord injury (SCI) poses a clinical challenge. We hypothesized that changes in the management of neurogenic bladder during pregnancy are commonly required and should receive more attention. METHODS: Data were collected by retrospective analysis of medical records and via cross-sectional survey of 52 women with SCI, representing 67 pregnancies, at ten Italian neurourological clinics. All participants provided informed consent...
March 29, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29599656/degenerative-cervical-myelopathy-a-clinical-review
#10
REVIEW
Justin Gibson, Aria Nouri, Bryan Krueger, Nikita Lakomkin, Rani Nasser, David Gimbel, Joseph Cheng
Degenerative Cervical Myelopathy (DCM) is the most common form of spinal cord impairment in adults and results in disability and reduced quality of life. DCM can present with a wide set of clinical and imaging findings, including: 1) pain and reduced range of motion of the neck, and motor and sensory deficits on clinical exam, and 2) cord compression due to static and dynamic injury mechanisms resulting from degenerative changes of the bone, ligaments, and intervertebral discs on MRI. The incidence and prevalence of DCM has been estimated at a minimum of 4...
March 2018: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/29584618/role-of-prongf-p75-signaling-in-bladder-dysfunction-after-spinal-cord-injury
#11
Jae Cheon Ryu, Katharine Tooke, Susan E Malley, Anastasia Soulas, Tirzah Weiss, Nisha Ganesh, Nabila Saidi, Stephanie Daugherty, Uri Saragovi, Youko Ikeda, Irina Zabbarova, Anthony J Kanai, Mitsuharu Yoshiyama, H Francis Farhadi, William C de Groat, Margaret A Vizzard, Sung Ok Yoon
Loss of bladder control is a challenging outcome facing patients with spinal cord injury (SCI). We report that systemic blocking of pro-nerve growth factor (proNGF) signaling through p75 with a CNS-penetrating small-molecule p75 inhibitor resulted in significant improvement in bladder function after SCI in rodents. The usual hyperreflexia was attenuated with normal bladder pressure, and automatic micturition was acquired weeks earlier than in the controls. The improvement was associated with increased excitatory input to the spinal cord, in particular onto the tyrosine hydroxylase-positive fibers in the dorsal commissure...
March 26, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29578382/pre-operative-screening-for-asymptomatic-bacteriuria-and-associations-with-post-operative-outcomes-in-patients-with-spinal-cord-injury
#12
Margaret A Fitzpatrick, Katie J Suda, Stephen P Burns, Linda Poggensee, Swetha Ramanathan, Charlesnika T Evans
CONTEXT: Screening for asymptomatic bacteriuria (ASB) before non-urologic surgery is common but of unclear benefit. Our aim was to describe pre-operative ASB screening and post-operative outcomes in patients with neurogenic bladder due to spinal cord injury (SCI). METHODS: This was a descriptive retrospective cohort study of adults with SCI undergoing neurosurgical spine or orthopedic lower limb surgery from 10/1/2012-9/30/2014 at Veterans Affairs (VA) medical centers...
March 26, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29569211/recommendations-for-urological-follow-up-of-patients-with-neurogenic-bladder-secondary-to-spinal-cord-injury
#13
REVIEW
Mikolaj Przydacz, Piotr Chlosta, Jacques Corcos
PURPOSE: To review currently available guidelines and recommendations regarding urological follow-up of patients after spinal cord injury (SCI) and present an evidence-based summary to support clinicians in their clinical practice. METHODS: Maximum data were collected according to different methods, including searches with multiple and specific keywords, reference checks, gray literature searches (congress reports, working papers, statement documents), and browsing-related Web site access...
March 22, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29563843/fatal-cerebral-hemorrhage-in-a-tetraplegic-patient-due-to-autonomic-dysreflexia-triggered-by-delay-in-emptying-urinary-bladder-after-unsuccessful-intermittent-catheterization-by-carer-lessons-learned
#14
Subramanian Vaidyanathan, Bakulesh M Soni, Peter L Hughes, Tun Oo
Introduction: Over-distension of urinary bladder in a high spinal cord injury patient is a triggering factor for autonomic dysreflexia. Removing triggering factors is vital to prevent autonomic dysreflexia. Case presentation: A 36-year-old tetraplegic patient, who was managed by intermittent catheterizations performed by caregivers, developed recurrent autonomic dysreflexia during a week due to: 1) carers not performing intermittent catheterizations every night; 2) infrequent catheterizations during the day, leading to distension of urinary bladder...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29551557/surgical-management-of-anatomic-bladder-outlet-obstruction-in-males-with-neurogenic-bladder-dysfunction-a-systematic-review
#15
REVIEW
Toscane C Noordhoff, Jan Groen, Jeroen R Scheepe, Bertil F M Blok
CONTEXT: Surgical treatment of anatomic bladder outlet obstruction (BOO) may be indicated in males with neurogenic bladder dysfunction. A bothersome complication after surgery is urinary incontinence. OBJECTIVE: To identify the optimal practice in the surgical treatment of anatomic BOO in males with neurogenic bladder dysfunction, due to multiple sclerosis, Parkinson disease, spinal cord injury (SCI), spina bifida, or cerebrovascular accident (CVA). EVIDENCE ACQUISITION: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement...
March 15, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29545043/outcomes-of-ureteroscopic-stone-treatment-in-spinal-cord-injury-patients
#16
Duncan R Morhardt, Miriam Hadj-Moussa, He Chang, J Stuart Wolf, William W Roberts, John T Stoffel, Gary J Faerber, Anne P Cameron
OBJECTIVE: To evaluate the association of clinical factors on outcomes in SCI patients undergoing ureteroscopy. Immobility, recurrent urinary tract infection, and lower urinary tract dysfunction contribute to renal stone formation in spinal cord injury (SCI) patients. Ureteroscopy is a commonly utilized treatment modality, however, surgical complication rates and outcomes have been poorly defined. Evidence guiding safe and effective treatment of stones in this cohort remains scarce. METHODS: Records were retrospectively reviewed for SCI patients who underwent ureteroscopy for kidney stones from 1996-2014 at a single institution...
March 12, 2018: Urology
https://www.readbyqxmd.com/read/29530711/mapping-and-neuromodulation-of-lower-urinary-tract-function-using-spinal-cord-stimulation-in-female-rats
#17
Huiyi H Chang, Jih-Chao Yeh, Ronaldo M Ichiyama, Larissa V Rodriguez, Leif A Havton
Spinal cord epidural stimulation (SCS) represents a form of neuromodulation for the management of spasticity and pain. This technology has recently emerged as a new approach for potentially augmenting locomotion and voiding function in humans and rodents after spinal cord injury. However, the effect of SCS on micturition has not been studied extensively. Here, SCS was first applied as a direct stimulus onto individual segmental levels of the lumbar spinal cord in rats to map evoked external urethral sphincter (EUS) electromyography activity and SCS-induced voiding contractions...
March 9, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29516546/the-effect-of-neutralization-of-nerve-growth-factor-ngf-on-bladder-and-urethral-dysfunction-in-mice-with-spinal-cord-injury
#18
Naoki Wada, Takahiro Shimizu, Nobutaka Shimizu, William C de Groat, Anthony J Kanai, Pradeep Tyagi, Hidehiro Kakizaki, Naoki Yoshimura
AIMS: To investigate the role of nerve growth factor (NGF) in lower urinary tract dysfunction in mice with spinal cord injury (SCI). METHODS: Using 4-week SCI mice, single-filling cystometry and external urethral sphincter (EUS)-electromyography were performed under an awake condition. In some SCI mice, anti-NGF antibodies (10 µg/kg/h) were administered for 1 or 2 weeks before the urodynamic study. NGF levels in the bladder and L6/S1 spinal cord were assayed by ELISA...
March 8, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29515214/complications-of-non-continent-cutaneous-urinary-diversion-in-adults-with-spinal-cord-injury-a-retrospective-study
#19
Cyrille Guillot-Tantay, Emmanuel Chartier-Kastler, Marie-Aimée Perrouin-Verbe, Pierre Denys, Priscilla Léon, Véronique Phé
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To report the long-term complications of non-continent cutaneous urinary diversion (NCCUD) in adult patients with spinal cord injury (SCI). SETTING: Hospital in Paris, France. METHODS: A retrospective single center study included all adult patients with SCI who underwent an ileal conduit between 1997 and 2014. Early complications were reported according to Clavien-Dindo classification...
March 7, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29509106/novel-method-for-restoration-of-anorectal-function-following-spinal-cord-injury-via-nerve-transfer-in-rats
#20
Bingbo Bao, Kai Fu, Xianyou Zheng, Haifeng Wei, Pengbo Luo, Hongyi Zhu, Xiaozhong Zhu, Xingwei Li, Tao Gao
OBJECTIVES: Nerve transfer has been developed to restore partial function after serious nerve injuries, for example, restoring bladder control after spinal cord injury (SCI). Our aim here was to establish a preclinical proof-of-concept model using nerve transfer for restoring anorectal function after SCI. SETTING: We used laminectomy to model SCI, and bilateral spinal ventral and dorsal nerve root anastomosis to re-establish connectivity to the anorectal musculature...
March 6, 2018: Journal of Spinal Cord Medicine
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