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Spinal cord injury bladder

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https://www.readbyqxmd.com/read/29449969/stigma-and-self-management-an-interpretative-phenomenological-analysis-of-the-impact-of-chronic-recurrent-urinary-tract-infections-after-spinal-cord-injury
#1
Jasmine Heath Hearn, Sen Selvarajah, Paul Kennedy, Julian Taylor
Study Design: Qualitative, phenomenological design. Objectives: Neurogenic bladder dysfunction and urinary tract infection (UTI) are common secondary consequences to neurological damage to the spinal cord. This study sought to establish the impact of chronic, recurrent UTIs on people with spinal cord injury (SCI). Setting: Community sample, United Kingdom. Methods: Twelve participants with SCI, aged between 28 and 68 years, who had experienced at least three recurrent UTI events within the previous 12 months were recruited...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29444239/therapeutic-efficacy-of-microtube-embedded-chondroitinase-abc-in-a-canine-clinical-model-of-spinal-cord-injury
#2
Hilary Z Hu, Nicolas Granger, S Balakrishna Pai, Ravi V Bellamkonda, Nick D Jeffery
Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies. Laboratory research in experimental animals has identified a large number of potentially translatable interventions but transition to the clinic is not straightforward. Further evidence of efficacy in more clinically-relevant lesions is required to gain sufficient confidence to commence human clinical trials. Of the many therapeutic candidates currently available, intraspinally applied chondroitinase ABC has particularly well documented efficacy in experimental animals...
February 9, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29436607/decreased-hyperpolarization-activated-cyclic-nucleotide-gated-channels-are-involved-in-bladder-dysfunction-associated-with-spinal-cord-injury
#3
Qian Liu, Chao Wu, Shengquan Huang, Qingjian Wu, Tao Zhou, Xiaobing Liu, Xin Liu, Xiaoyan Hu, Longkun Li
Spinal cord injury (SCI) leads to bereft voluntary control of bladder, but the possible role of spontaneous excited system in bladder of SCI patients is poorly understood. Hyper-polarization-activated cyclic nucleotide-gated (HCN) channels are deemed to regulate the spontaneous contraction of bladder, our study explored the functional role of HCN channels in SCI induced neurogenic bladder. Sixty female Sprague-Dawley rats were randomized into control, sham and SCI groups. Rat models subjected to SCI at S2 levels were successfully established and were assessed using hematoxylin and eosin staining and cystometry...
February 13, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29427331/the-role-of-the-mucosa-in-modulation-of-evoked-responses-in-the-spinal-cord-injured-rat-bladder
#4
Claire Doyle, Vivian Cristofaro, Bryan S Sack, Fabliha Mahmood, Maryrose P Sullivan, Rosalyn M Adam
AIMS: Mounting evidence indicates that a variety of factors released from the urothelium or suburothelium can modulate smooth muscle activity. Although the relationship between the mucosa and smooth muscle has been investigated, little is known about the pathophysiologic changes in detrusor-mucosa interactions in neurogenic bladders. The goal of the study was to determine the impact of the mucosa on evoked responses in spinal cord injured (SCI) bladders. METHODS: Urinary bladders were obtained from 6wk SCI rats or age-matched uninjured controls...
February 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29423307/the-importance-of-the-bulbocavernosus-reflex
#5
REVIEW
Jean Gabriel Previnaire
The BCR consists of the contraction of the bulbocavernosus muscle in response to squeezing the glans penis or clitoris, and is mediated through the pudendal nerve. In case of a complete lesion, the presence of BCR is indicative of intact S2-S4 spinal reflex arcs and loss of supraspinal inhibition, determining an upper motor neuron (UMN) lesion, its absence a lower motor neuron (LMN) lesion. The BCR further helps distinguish conus medullaris from cauda equina syndromes. Sensory or motor function in the most caudal sacral segments, not BCR, defines the sacral sparing as part of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI)...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29412074/macroplastique-and-botox-are-superior-to-macroplastique-alone-in-the-management-of-neurogenic-vesicoureteric-reflux-in-spinal-cord-injury-population-with-presumed-healthy-bladders
#6
Vasileios I Sakalis, Rachel Oliver, Peter J Guy, Melissa C Davies
CONTEXT/OBJECTIVE: Vesico-ureteric reflux(VUR) is a known complication of neuropathic bladder in spinal cord injury(SCI) population. Bulking agents such as Macroplastique are new minimally-invasive treatment option for VUR with good results. The aim of this study is to assess the efficacy of Macroplastique alone or in combination with Botox(BTX-A), in managing VUR in SCI population with presumed healthy bladders and correlate the pre-and post-injection urodynamic findings with the outcome...
February 7, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29405883/the-importance-of-the-clinical-examination-of-the-lower-sacral-segments-four-case-reports
#7
Maria João Andrade, Tiago Felix Soares
CONTEXT: In our practice, in a spinal cord injury unit, clinical examinations include anal sensation and voluntary anal contraction, which are essential for neurological classification of spinal cord injury according to international standards (ISNCSCI), but we also always examine the integrity of the sacral segments, testing anal tone and anal and bulbocavernosus reflexes (S2-S4 segments) and the dartos reflex to evaluate the thoracolumbar sympathetic pathway. FINDINGS: In this paper, we describe four case reports of bladder dysfunction in which a clinical examination of the lower sacral segments was decisive to identify the neurological etiology...
February 6, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29392753/value-of-urodynamic-findings-in-predicting-upper-urinary-tract-damage-in-neuro-urological-patients-a-systematic-review
#8
REVIEW
Stefania Musco, Barbara Padilla-Fernández, Giulio Del Popolo, Matteo Bonifazi, Bertil F M Blok, Jan Groen, Lisette 't Hoen, Jürgen Pannek, Jerome Bonzon, Thomas M Kessler, Marc P Schneider, Tobias Gross, Gilles Karsenty, Véronique Phé, Rizwan Hamid, Hazel Ecclestone, David Castro-Diaz
AIM: The main goals of neurogenic lower urinary tract dysfunction (NLUTD) management are preventing upper urinary tract damage (UUTD), improving continence, and quality of life. Here, we aimed to systematically assess all available evidence on urodynamics predicting UUTD in patients with NLUTD. METHODS: A systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement was performed in March 2017. Only neuro-urological patients assessed by urodynamics were included...
February 2, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29385166/improvements-in-bladder-bowel-and-sexual-outcomes-following-task-specific-locomotor-training-in-human-spinal-cord-injury
#9
Charles H Hubscher, April N Herrity, Carolyn S Williams, Lynnette R Montgomery, Andrea M Willhite, Claudia A Angeli, Susan J Harkema
OBJECTIVE: Locomotor training (LT) as a therapeutic intervention following spinal cord injury (SCI) is an effective rehabilitation strategy for improving motor outcomes, but its impact on non-locomotor functions is unknown. Given recent results of our labs' pre-clinical animal SCI LT studies and existing overlap of lumbosacral spinal circuitries controlling pelvic-visceral and locomotor functions, we addressed whether LT can improve bladder, bowel and sexual function in humans at chronic SCI time-points (> two years post-injury)...
2018: PloS One
https://www.readbyqxmd.com/read/29382457/gentamicin-bladder-instillations-decrease-symptomatic-urinary-tract-infections-in-neurogenic-bladder-patients-on-intermittent-catheterization
#10
Lindsey Cox, Chang He, Jack Bevins, J Quentin Clemens, John T Stoffel, Anne P Cameron
INTRODUCTION: This study aimed to determine if gentamicin bladder instillations reduce the rate of symptomatic urinary tract infection (UTI) in neurogenic bladder (NGB) patients on intermittent self-catheterization (ISC) who have recurrent UTIs. Secondary aims were to examine the effects of intravesical gentamicin on the organism resistance patterns. METHODS: We retrospectively reviewed our prospective NGB database. Inclusion criteria were NGB patients performing ISC exclusively for bladder drainage with clinical data available for six months before and six months after initiating prophylactic intravesical gentamicin instillations...
September 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29372544/drug-targets-in-neurotrophin-signaling-in-the-central-and-peripheral-nervous-system
#11
REVIEW
Mahendra Pratap Kashyap, Callie Roberts, Mohammad Waseem, Pradeep Tyagi
Neurotrophins are a family of proteins that play an important role in the regulation of the growth, survival, and differentiation of neurons in the central and peripheral nervous system. Neurotrophins were earlier characterized by their role in early development, growth, maintenance, and the plasticity of the nervous system during development, but recent findings also indicate their complex role during normal physiology in both neuronal and non-neuronal tissues. Therefore, it is important to recognize a deficiency in the expression of neurotrophins, a major factor driving the debilitating features of several neurologic and psychiatric diseases/disorders...
January 25, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29355293/bladder-irrigation-with-chlorhexidine-reduces-bacteriuria-in-persons-with-spinal-cord-injury
#12
Madeleine Wikström, Richard Levi, Wolfram Antepohl
OBJECTIVE: To explore whether bladder irrigation with chlorhexidine: (i) can reduce bacteriuria, and (ii) is a practically feasible option in subjects with spinal cord injury practicing intermittent self-catheterization. DESIGN: A prospective, non-controlled, open, multi-centre study. METHODS: Fifty patients with spinal cord injury, practicing intermittent self-catheterization, with a history of recurrent urinary tract infections were screened for bacteriuria at follow-up visits to 4 spinal cord injury centres in Sweden...
January 22, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29354507/real-world-treatment-patterns-in-the-neurogenic-bladder-population-a-systematic-literature-review
#13
REVIEW
Ashley Jaggi, Francis Fatoye
Myriad treatment modalities are available for neurogenic bladder (NGB) including behavioral therapies, oral pharmacotherapy, catheterization and surgical procedures. Little is known about how NGB patients are managed in the real world, how well patterns relate to clinical guidelines and how strategies may have changed over time. To address this gap, a systematic review (SR) was conducted using MEDLINE and EMBASE [1996-2017]. The inclusion criteria for studies were: (I) published in English; (II) conducted in human subjects; (III) reporting the treatment patterns/use in NGB; (IV) conducted in a real world setting...
December 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29352989/detrusor-acontractility-after-acute-spinal-cord-injury-myth-or-reality
#14
Mirjam Bywater, Jure Tornic, Ulrich Mehnert, Thomas M Kessler
PURPOSE: We assessed urodynamic parameters within the first 40 days after spinal cord injury (SCI) investigating whether the detrusor is acontractile during the acute phase of SCI. PATIENTS AND METHODS: We performed a prospective cohort study including 54 patients with neurogenic lower urinary tract dysfunction (NLUTD) due to acute SCI undergoing urodynamic investigation (UDI) within the first 40 days after injury at a single university SCI center. RESULTS: and Limitations: Of the 54 patients, UDI revealed an acontractile detrusor in only 20 (37%) but unfavorable urodynamic parameters in a total of 34 (63%) patients...
January 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29334338/at-home-genital-nerve-stimulation-for-individuals-with-sci-and-neurogenic-detrusor-overactivity-a-pilot-feasibility-study
#15
Dennis J Bourbeau, Kenneth J Gustafson, Steven W Brose
OBJECTIVE: Neurogenic bladder dysfunction, including neurogenic detrusor overactivity (NDO) is one of the most clinically significant problems for persons with spinal cord injury (SCI), affecting health and quality of life. Genital nerve stimulation (GNS) can acutely inhibit NDO-related reflex bladder contractions and increase bladder capacity. However, it is unknown if GNS can improve urinary continence or help meet individuals' bladder management goals during sustained use, which is required for GNS to be clinically effective...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29323625/catheter-associated-urinary-tract-infections-in-persons-with-neurogenic-bladders
#16
Todd A Linsenmeyer
This review is based on the author's Donald Munro Lecture given at the annual conference of the Academy of Spinal Cord Injury Professionals in New Orleans, LA. Indwelling catheters play an important role in bladder management following SCI for many individuals with neurogenic bladders. There is an increased risk of UTI compared to other types of bladder management with indwelling urethral catheters but not SP catheters. To minimize the risk of symptomatic UTI, the following steps are essential: prevent bladder wall distention and resulting ischemia, maintain colonization with "good" bacteria, and prevent bladder stones...
January 11, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29323623/bladder-management-practices-in-spinal-cord-injury-patients-a-single-center-experience-from-a-developing-country
#17
Sahibzada Nasir Mansoor, Farooq Azam Rathore
CONTEXT/OBJECTIVE: Inadequate bladder management in spinal cord injury (SCI) patients results in significant morbidity and even mortality. Clean intermittent catheterization (CIC) is the recommended option for SCI patients. The objective of the study was to document the bladder management practices of SCI patients in a developing country. DESIGN: Questionnaire based cross sectional survey Setting: Armed Forces Institute of Rehabilitation Medicine, Rawalpindi, Pakistan Participants: All patients with SCI (irrespective of duration, level and etiology) Interventions: Data documentation included demographics, level, severity and time since injury, bladder management techniques used, details of CIC, results of Urodynamic studies (if available), complications resulting from bladder management technique and patient awareness of the yearly follow up...
January 11, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29321550/evaluating-estimated-glomerular-filtration-rates-of-creatinine-and-cystatin-c-for-male-patients-with-chronic-spinal-cord-injury
#18
Takuro Goto, Yoshihide Kawasaki, Jun Takemoto, Yuko Abe, Takashige Namima
STUDY DESIGN: Retrospective study OBJECTIVES: To compare the accuracy of estimated serum creatinine (Cre)-based glomerular filtration rates (eGFRcre) and serum cystatin C (CysC)-based eGFR (eGFRcys) for determining renal function in patients with spinal cord injury (SCI). SETTING: Department of Urology, Tohoku Rosai Hospital, Japan METHODS: Male patients with SCI for longer than 5 years after injury were eligible for inclusion in this study. eGFRcre and eGFRcys were calculated using the following formulas: eGFRcre = 194 × Cre-1...
January 10, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29314212/lumbar-to-sacral-root-rerouting-to-restore-bladder-function-in-a-feline-spinal-cord-injury-model-urodynamic-and-retrograde-nerve-tracing-results-from-a-pilot-study
#19
Ornella Lam Van Ba, Mary F Barbe, Romain Caremel, Shachar Aharony, Oleg Loutochin, Line Jacques, Matthew W Wood, Ekta Tiwari, Gerald F Tuite, Lysanne Campeau, Jacques Corcos, Michael R Ruggieri
AIMS: Lumbar to sacral rerouting surgery can potentially allow voiding via a skin-central nervous system-bladder reflex pathway. Here, we assessed if this surgery was effective in treating neurogenic bladder dysfunction/sphincter in felines. METHODS: Eight cats underwent spinal cord transection (SCT) at thoracic level 10/11. Unilateral L7 to S1 ventral root anastomosis was performed 1 month later in six cats. Two cats served as transection-only controls. Electrical and manual stimulation of L6-S1 dermatomes, and urodynamics were performed at 3, 5, 7, and 9/10 months post transection...
January 4, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29306638/rectus-abdominis-detrusor-myoplasty-radm-for-acontractile-hypocontractile-bladder-in-spinal-cord-injury-patients-preliminary-report
#20
Pawan Agarwal, Shabbir Husain, Sudesh Wankhede, D Sharma
BACKGROUND: Urinary bladder dysfunction in the form of acontractile/hypocontractile bladder is very common after spinal cord injury and it may lead to recurrent urinary tract infection (UTI), stones formation, and deteriorating renal function. Conventionally, these patients evacuate their bladders by life-long clean intermittent catheterization (CIC) or an indwelling catheter (IC). For these patients, another option is to use innervated skeletal muscle wrap around the bladder to augment detrusor function and voluntary evacuation of bladder...
December 14, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
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