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Spinal cord injury bladder

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https://www.readbyqxmd.com/read/28447605/traumatic-spinal-cord-injury
#1
REVIEW
Christopher S Ahuja, Jefferson R Wilson, Satoshi Nori, Mark R N Kotter, Claudia Druschel, Armin Curt, Michael G Fehlings
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and vocational well-being of patients. The demographic of SCIs is shifting such that an increasing proportion of older individuals are being affected. Pathophysiologically, the initial mechanical trauma (the primary injury) permeabilizes neurons and glia and initiates a secondary injury cascade that leads to progressive cell death and spinal cord damage over the subsequent weeks. Over time, the lesion remodels and is composed of cystic cavitations and a glial scar, both of which potently inhibit regeneration...
April 27, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28407430/chronic-urinary-tract-infections-in-patients-with-spinal-cord-lesions-biofilm-infection-with-need-for-long-term-antibiotic-treatment
#2
REVIEW
Nete Tofte, Alex C Y Nielsen, Hannah Trøstrup, Christine B Andersen, Michael Von Linstow, Birgitte Hansen, Fin Biering-Sørensen, Niels Høiby, Claus Moser
Patients suffering from spinal cord injuries resulting in complete or incomplete paraplegia or tetraplegia are highly disposed to frequent, recurrent or even chronic urinary tract infections (UTIs). The reason for the increased risk of acquiring UTIs is multifactorial, including reduced sensation of classical UTI symptoms, incomplete bladder emptying, frequent catheterizations or chronic urinary tract catheters. Biofilms in relation to UTIs have been shown both on catheters, on concrements or as intracellular bacterial communities (IBCs)...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28407301/impact-of-clean-intermittent-catheterization-on-quality-adjusted-life-years-qalys-in-spinal-cord-injury-patients-with-neurogenic-urinary-incontinence
#3
Jan Svihra, Jan Krhut, Roman Zachoval, Viera Svihrova, Jan Luptak
AIMS: The impact of clean intermittent catheterization (CIC) on quality adjusted life years (QALYs) gained in adults' spinal cord injury population with neurogenic urinary incontinence (UI). METHODS: Patients were recruited from the national registry January-June 2014. The inclusion criteria were adults, neurogenic UI due to spinal cord injury (SCI), use of collection devices and CIC for more than 6 months. The exclusion criteria were inability to perform CIC, cancer of the lower urinary tract and fistulas formation...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28406070/an-investigation-of-the-relationship-between-autonomic-dysreflexia-and-intrathecal-baclofen-in-patients-with-spinal-cord-injury
#4
Anna Sophia Del Fabro, Melvin Mejia, Gregory Nemunaitis
OBJECTIVE: To study the relationship between autonomic dysreflexia and intrathecal baclofen in patients with spinal cord injury. DESIGN: Retrospective chart review. SETTING: Inpatient and outpatient acute rehabilitation facility. PARTICIPANTS: Thirty-four subjects. INTERVENTIONS: We reviewed patients' medical records to ascertain the presence of symptomatic autonomic dysreflexia (AD) prior to and after implantation of an intrathecal baclofen (ITB) pump for spasticity in spinal cord injury patients...
April 13, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28400810/tanshinone-iia-improves-functional-recovery-in-spinal-cord-injury-induced-lower-urinary-tract-dysfunction
#5
Yong-Dong Yang, Xing Yu, Xiu-Mei Wang, Xiao-Hong Mu, Feng He
Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone IIA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration...
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28398301/expression-of-autophagy-in-different-stages-of-neurogenic-bladder-after-spinal-cord-injury-in-rats
#6
F-S Zeng, L Zhang, B-J Cui, L-G Huang, Q Zhang, M Sun, B-L Liu, F Meng, Q Li, D-Q Wang, Q-S Sun
STUDY DESIGN: Experimental study. OBJECTIVES: To investigate the expression of autophagy in different stages of the neurogenic bladder after spinal cord injury (SCI) in rats. SETTING: Second Hospital of Shandong University, Jinan, China. METHODS: A total of 36 Wistar rats were divided into the SCI and control groups. In total, six animals were killed and sampled from each group at 1, 4 and 14 days after surgery of T10-T11 level...
April 11, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28382215/central-cord-syndrome-from-blast-injury-after-gunshot-wound-to-the-spine-a-case-report-and-a-review-of-the-literature
#7
Juan Galloza, Juan Valentin, Edwardo Ramos
INTRODUCTION: Central Cord Syndrome (CCS) is the most common of the spinal cord injury syndromes. Few cases have been presented with gunshot wound (GSW) as a cause of a central cord syndrome, and none, to our knowledge, has been presented without any evidence of central canal bullet/bone fragments. CASE PRESENTATION: A 27-year-old male suffered two close-range gunshot wounds, one to the left neck and one to the left shoulder. CT scan showed C5 spinous process fracture and paraspinal muscle hemorrhage without evidence of central canal stenosis or bullet/bone fragments...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28362188/spinal-column-shortening-for-tethered-cord-syndrome-associated-with-myelomeningocele-lumbosacral-lipoma-and-lipomyelomeningocele-in-children-and-young-adults
#8
Guillermo Aldave, Daniel Hansen, Steven W Hwang, Amee Moreno, Valentina Briceño, Andrew Jea
OBJECTIVE Tethered cord syndrome is the clinical manifestation of an abnormal stretch on the spinal cord, presumably causing mechanical injury, a compromised blood supply, and altered spinal cord metabolism. Tethered cord release is the standard treatment for tethered cord syndrome. However, direct untethering of the spinal cord carries potential risks, such as new neurological deficits from spinal cord injury, a CSF leak from opening the dura, and retethering of the spinal cord from normal scar formation after surgery...
March 31, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28361517/structural-changes-of-the-urinary-bladder-after-chronic-complete-spinal-cord-injury-in-minipigs
#9
Elena E Foditsch, Karin Roider, Irina Patras, Ioan Hutu, Sophina Bauer, Günter Janetschek, Reinhold Zimmermann
PURPOSE: The aim of this study was to determine the structural changes of the urinary bladder after chronic spinal cord injury (SCI) in minipigs with the primary focus on the analysis of urinary bladder wall proteins and their quantitative distribution. METHODS: Seven Göttingen minipigs (adult, female) underwent a complete spinal cord transection. Follow-up time was 4 months during which the bladder was drained by frequent single catheterisation and data from the bladder diary and daily urine strip test were collected...
March 24, 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28332134/clinical-characteristics-of-bladder-cancer-in-patients-with-spinal-cord-injury-the-experience-from-a-single-centre
#10
Ralf Böthig, Ines Kurze, Kai Fiebag, Albert Kaufmann, Wolfgang Schöps, Thura Kadhum, Michael Zellner, Klaus Golka
INTRODUCTION: Life expectancy for people with spinal cord injury has shown a marked increase due to modern advances in treatment methods and in neuro-urology. However, since life expectancy of people with paralysis increases, the risk of developing of urinary bladder cancer is gaining importance. MATERIALS AND METHODS: Single-centre retrospective evaluation of patient data with spinal cord injuries and proven urinary bladder cancer and summary of the literature...
March 22, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28331065/urothelial-proliferation-and-regeneration-after-spinal-cord-injury
#11
F Aura Kullmann, Dennis R Clayton, Wily G Ruiz, Amanda Wolf-Johnson, Christian Gauthier, Anthony J Kanai, Lori A Birder, Gerard Apodaca
The basal, intermediate, and superficial cell layers of the urothelium undergo rapid and complete recovery following acute injury; however, the effects of chronic injury on urothelial regeneration have not been well defined. To address this discrepancy, we employed a mouse model to explore urothelial changes in response to spinal cord injury (SCI), a condition characterized by life-long bladder dysfunction. One-day post SCI there was a focal loss of umbrella cells, which are large cells that populate the superficial cell layer and normally express uroplakins (UPKs) and KRT20, but not KRT5, KRT14, or TP63...
March 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28322903/urological-management-and-complications-in-spinal-cord-injury-patients-a-40-to-50-year-follow-up-study
#12
Yunliang Gao, Teresa Danforth, David Ginsberg
OBJECTIVES: To assess the management and types of urological complications in spinal cord injury (SCI) patients and to explore the risk factors for these complications. METHODS: 43 SCI patients with a median follow-up of 45 (range 40 to 50) years were included in this retrospective study. All medical charts were reviewed for demographics, urological complications and bladder management. RESULTS: Recurrent urinary tract infection (UTI) was noted in all patients, with an average incidence of 6...
March 16, 2017: Urology
https://www.readbyqxmd.com/read/28322241/leisure-time-physical-activity-among-older-adults-with-long-term-spinal-cord-injury
#13
S Jörgensen, K A Martin Ginis, J Lexell
STUDY DESIGN: Cross-sectional. OBJECTIVES: To describe participation in leisure time physical activity (LTPA) (amount, intensity and type) among older adults with long-term spinal cord injury (SCI), and to investigate the associations with sociodemographics, injury characteristics and secondary health conditions (SHCs). SETTING: Home settings in southern Sweden. METHODS: Data from the Swedish Aging with Spinal Cord Injury Study (SASCIS)...
March 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28294142/inosine-attenuates-spontaneous-activity-in-the-rat-neurogenic-bladder-through-an-a2b-pathway
#14
Claire Doyle, Vivian Cristofaro, Bryan S Sack, Stefan N Lukianov, Mattias Schäfer, Yeun Goo Chung, Maryrose P Sullivan, Rosalyn M Adam
Neurogenic detrusor overactivity (NDO) is among the most challenging complications of spinal cord injury (SCI). A recent report by us demonstrated an improvement in NDO in SCI rats following chronic systemic treatment with the purine nucleoside inosine. The objective of this study was to investigate the mechanism of action of inosine underlying improvement of NDO. Male Sprague-Dawley rats underwent complete spinal cord transection at T8. Inosine (1 mM) delivered intravesically to SCI rats during conscious cystometry significantly decreased the frequency of spontaneous non-voiding contractions...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28269570/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#15
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267560/neurogenic-bladder-dysfunction-does-not-correlate-with-astrocyte-and-microglia-activation-produced-by-graded-force-in-a-contusion-induced-spinal-cord-injury
#16
Alvaro Munoz
Rodent models for the study of neurogenic bladder dysfunction after spinal cord injury (SCI) are difficult to standardize, particularly when evaluating the specific contribution of the SCI to end-organ function. The purpose of this study was to evaluate the degree of bladder dysfunction associated with a highly reproducible, contusion-induced SCI in female rats. An infinite horizon impactor was used to create a contusion SCI with a magnitude of either 100 or 150 kDyne at the T8/T9 thoracic region of female Sprague-Dawley rats...
March 3, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28262538/bladder-perforation-after-augmentation-cystoplasty-determining-the-best-management-option
#17
Ted Lee, David J Kozminski, David A Bloom, Julian Wan, John M Park
INTRODUCTION: Delayed bladder perforation is a well-described complication after augmentation cystoplasty. Although the frequency, risk factors, and diagnostic challenges are well documented, discussions regarding management strategies are sparse. OBJECTIVE: We evaluated our experience of managing augmented bladder perforation to interrogate the hypothesis that non-operative management can be used effectively. STUDY DESIGN: We retrospectively evaluated the management of 10 patients with augmented bladder perforations over a 16-year period (Jan 2000-Jan 2016)...
February 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28244500/social-activity-and-relationship-changes-experienced-by-people-with-bowel-and-bladder-dysfunction-following-spinal-cord-injury
#18
S Braaf, A Lennox, A Nunn, B Gabbe
STUDY DESIGN: Exploratory qualitative. OBJECTIVES: The aim of this study was to describe the experiences of bowel and bladder dysfunction on social activities and relationships in people with spinal cord injury living in the community. SETTING: People living with spinal cord injury experiencing bowel and bladder dysfunction. METHODS: Participants were recruited through the Australian Quadriplegic Association Victoria...
February 28, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28227825/real-time-autonomous-bladder-event-classification-and-closed-loop-control-from-single-channel-pressure-data
#19
Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Robert Karam, Swarup Bhunia, Steve Majerus, Steven W Brose, Margot S Damaser, Dennis Bourbeau, Steve Majerus, Margot S Damaser, Robert Karam, Steven W Brose, Dennis Bourbeau, Swarup Bhunia
Urinary incontinence, or the loss of bladder control, is a debilitating condition affecting millions worldwide, which significantly reduces quality of life. Neuromodulation of lower urinary tract nerves can be used to treat sensations of urgency in many subjects, including those with Spinal Cord Injury (SCI). Event driven, or conditional stimulation has been investigated as a possible improvement to the state-of-the-art open-loop stimulation systems available today. However, this requires a robust, adaptive, and noise-tolerant method of classifying bladder function from real-time bladder pressure measurements...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220823/treatment-of-stress-urinary-incontinence-in-men-with-spinal-cord-injury-minimally-invasive-minimally-effective
#20
J Pannek, J Wöllner
STUDY DESIGN: Retrospective chart review. OBJECTIVES: To assess the outcome of minimally invasive treatment of stress urinary incontinence with alloplastic slings in patients with neurogenic lower urinary tract dysfunction. SETTING: Switzerland. METHODS: The patient database of a tertiary urologic referral center was screened for male patients with SCI who underwent implantation of a suburethral sling between June 2009 and December 2015...
February 21, 2017: Spinal Cord
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