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https://www.readbyqxmd.com/read/28932505/the-features-of-morphological-changes-in-the-urinary-bladder-under-combined-effect-of-heavy-metal-salts
#1
Anatolii Romaniuk, Vladyslav Sikora, Mykola Lyndin, Vladyslav Smiyanov, Volodymyr Sikora, Yulia Lyndina, Artem Piddubnyi, Nataliya Gyryavenko, Anna Korobchanska
PURPOSE: This study is aimed to the investigation of the features of morphological changes in the urinary bladder of mature rats. RESULTS: Received results shown that the experimental group of rats that had the intake of heavy metal salts (HMS) mixture during 30 and 90 days were observed histological and immunohistochemical changes in all structures of the urinary bladder. Depending on the period of influence of heavy metal ions on the wall of the organ, the pathological changes developed in cellular layers of the wall can lead to degenerative and later to atrophic and sclerotic changes...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28922799/restoring-victory-naval-heritage-identity-and-memory-in-interwar-britain
#2
Don Leggett
In the decade following 1918, HMS Victory was restored as a memorial to the nation, empire, the Navy, and all the sailors who had lost their lives in the Great War. This piece of Britain's naval heritage became a focal point for Great War memory and a resource for narrating the Navy's place in post-war Britain. This article analyses the restoration campaign, focusing on its appeal work and the materials it produced, discourses surrounding the restoration and the use of Victory's oak to recover this ship's importance at the intersection between Britain and its Navy in the aftermath of the Great War, and the function that the Navy played in the construction of post-war memory and identity...
March 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28905437/the-use-of-traditional-herbal-medicines-amongst-south-asian-diasporic-communities-in-the-uk
#3
Sukvinder K Bhamra, Adrian Slater, Caroline Howard, Mark Johnson, Michael Heinrich
Migrant South Asian communities in the UK have brought with them their own traditional forms of medicine, yet little is known about their current use of herbal medicines (HMs) in the UK. The aim of the study was to explore the origins, use and transmission of knowledge of traditional HMs used by diasporic South Asian communities in the UK. A researcher-administered questionnaire was used for data collection (n = 192). An opportunity sampling technique was used to recruit participants across several locations in Birmingham and Leicester...
September 14, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28898532/immunological-efficacy-of-herbal-medicines-in-prostate-cancer-patients-treated-by-personalized-peptide-vaccine
#4
Noriko Koga, Fukuko Moriya, Kayoko Waki, Akira Yamada, Kyogo Itoh, Masanori Noguchi
This randomized phase II study investigated the immunological efficacy of herbal medicines (HMs) using Hochu-ekki-to and Keishi-bukuryo-gan in combination with personalized peptide vaccination (PPV) for castration-resistant prostate cancer (CRPC). Seventy patients with CRPC were assigned to two arms; PPV plus HMs or PPV alone. Two to four peptides were chosen from 31 peptides derived from cancer antigens for the eight-time subcutaneous injection of PPV according to the patient's human leukocyte antigen type and levels of antigen-specific immunoglobulin G (IgG) titer before PPV treatment...
September 12, 2017: Cancer Science
https://www.readbyqxmd.com/read/28894233/a-ph-dependent-antibacterial-peptide-release-nano-system-blocks-tumor-growth-in-vivo-without-toxicity
#5
Jing Cao, Yan Zhang, Yanke Shan, Jingui Wang, Fei Liu, Hongrui Liu, Gang Xing, Jing Lei, Jiyong Zhou
In this study, we designed a nano-system where a novel antibacterial peptide RGD-hylin a1 with reduced hemolysis than the commonly studied melittin was loaded onto mesoporous silica (HMS). We found out that the designed nano-system, RGD-hylin a1-HMS, released RGD-hylin a1 in a pH-dependent manner. It caused apoptosis of cancer cells at low dosage of the antibacterial peptide at pH = 5.5, but was safe to the cells at pH = 7. The hemolytic activity of RGD-hylin a1 itself was reduced by 50~100% by the nano-system depending on the dosage...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893502/recent-advances-in-nanoscale-metal-assisted-biochar-derived-from-waste-biomass-used-for-heavy-metals-removal
#6
REVIEW
Shih-Hsin Ho, Shishu Zhu, Jo-Shu Chang
Pollution of heavy metals (HMs) is a detrimental treat to human health and need to be cleaned up in a proper way. Biochar (BC), a low-cost and "green" adsorbent, has attracted significant attention due to its considerable HMs removal capacity. In particular, nano-metals have recently been used to assist BC in improving its reactivity, surface texture and magnetism. Synthesis methods and metal precursors greatly influence the properties and structures of the nanocomposites, thereby affecting their HMs removal performance...
August 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28892119/prophylactic-chemotherapy-for-hydatidiform-mole-to-prevent-gestational-trophoblastic-neoplasia
#7
REVIEW
Qiuyi Wang, Jing Fu, Lina Hu, Fang Fang, Lingxia Xie, Hengxi Chen, Fan He, Taixiang Wu, Theresa A Lawrie
BACKGROUND: This is an update of the original Cochrane Review published in Cochrane Library, Issue 10, 2012.Hydatidiform mole (HM), also called a molar pregnancy, is characterised by an overgrowth of foetal chorionic tissue within the uterus. HMs may be partial (PM) or complete (CM) depending on their gross appearance, histopathology and karyotype. PMs usually have a triploid karyotype, derived from maternal and paternal origins, whereas CMs are diploid and have paternal origins only...
September 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28891954/assessment-of-heavy-metal-pollution-and-health-risks-in-the-soil-plant-human-system-in-the-yangtze-river-delta-china
#8
Bifeng Hu, Xiaolin Jia, Jie Hu, Dongyun Xu, Fang Xia, Yan Li
Heavy metal (HM) contamination and accumulation is a serious problem around the world due to the toxicity, abundant sources, non-biodegradable properties, and accumulative behaviour of HMs. The degree of soil HM contamination in China, especially in the Yangtze River Delta, is prominent. In this study, 1822 pairs of soil and crop samples at corresponding locations were collected from the southern Yangtze River Delta of China, and the contents of Ni, Cr, Zn, Cd, As, Cu, Hg, and Pb were measured. The single pollution index in soil (SPI) and Nemerow composite pollution index (NCPI) were used to assess the degree of HM pollution in soil, and the crop pollution index (CPI) was used to explore the degree of HM accumulation in crops...
September 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28879804/evaluation-of-the-endocrine-disrupting-effects-of-homosalate-hms-and-2-ethylhexyl-4-dimethylaminobenzoate-od-paba-in-rat-pups-during-the-prenatal-lactation-and-early-postnatal-periods
#9
Meltem Erol, Ismet Çok, Özlem Bostan Gayret, Pembegül Günes, Özgül Yigit, Elif Sayman, Aysegül Günes, Duygu Sultan Çelik, Sahin Hamilçikan, Serdar Altinay, Oya Ercan
Homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) are ultraviolet filters. We aimed to investigate the effects of dermal exposure to HMS and OD-PABA during the prenatal, lactation, and early infancy periods on pubertal development and thyroid function in male and female rats. The thyroid glands, uteri, testes, prostate glands, and seminal vesicles were excised and weighed, the reproductive organs were analyzed histologically, and the serum hormone levels were measured. In the prenatal period, the thyroxine (T4) levels increased in the female rats in the exposed groups ( p < 0...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28875876/commercial-herbal-medicines-used-as-african-traditional-medicines-ngoma-herbal-tonic-immune-booster-interferes-with-a-rapid-urine-drug-screening-test
#10
M E Mothibe, E Osuch, C P Kahler-Venter
BACKGROUND: The prevalent use of African traditional medicine by the general public has been reported. With commercialisation and marketing, some of the herbal medicines (HMs) used are readily available over the counter, most of them promoted as immune boosters. These commercial HMs have not been taken through clinical trials and other tests that would validate their composition and safety, and other properties such as their effect on laboratory diagnostic tests. OBJECTIVE: To investigate the cross-reactivity of selected HMs with commonly tested drugs of abuse (DoA) using a qualitative rapid urinalysis assay...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28874401/chemical-uv-filters-can-affect-human-sperm-function-in-a-progesterone-like-manner
#11
Anders Rehfeld, Dorte Egeberg, Kristian Almstrup, Jørgen Holm Petersen, Steen Dissing, Niels Erik Skakkebæk
Human sperm cell function must be precisely regulated to achieve natural fertilization. Progesterone released by the cumulus cells surrounding the egg induces a Ca2+-influx into human sperm cells via the CatSper Ca2+-channel and thereby controls sperm function. Multiple chemical UV filters have been shown to induce a Ca2+-influx through CatSper, thus mimicking the effect of progesterone on Ca2+-signaling. We hypothesized that these UV filters could also mimic the effect of progesterone on sperm function. We examined 29 UV filters allowed in sunscreens in the US and/or EU for their ability to affect acrosome reaction, penetration, hyperactivation, and viability in human sperm cells...
September 5, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28870710/communication-skills-training-in-ophthalmology-results-of-a-needs-assessment-and-pilot-training-program
#12
Anuradha Mishra, David Browning, Miriam J Haviland, Mary Lou Jackson, Donna Luff, Elaine C Meyer, Katherine Talcott, Carolyn E Kloek
OBJECTIVE: To conduct a needs assessment to identify gaps in communication skills training in ophthalmology residency programs and to use these results to pilot a communication workshop that prepares residents for difficult conversations. DESIGN: A mixed-methods design was used to perform the needs assessment. A pre-and postsurvey was administered to workshop participants. SETTING: Mass Eye and Ear Infirmary, Harvard Medical School (HMS), Department of Ophthalmology...
September 1, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28862395/phelan-mcdermid-syndrome-data-network-integrating-patient-reported-outcomes-with-clinical-notes-and-curated-genetic-reports
#13
Cartik Kothari, Maxime Wack, Claire Hassen-Khodja, Sean Finan, Guergana Savova, Megan O'Boyle, Geraldine Bliss, Andria Cornell, Elizabeth J Horn, Rebecca Davis, Jacquelyn Jacobs, Isaac Kohane, Paul Avillach
The heterogeneity of patient phenotype data are an impediment to the research into the origins and progression of neuropsychiatric disorders. This difficulty is compounded in the case of rare disorders such as Phelan-McDermid Syndrome (PMS) by the paucity of patient clinical data. PMS is a rare syndromic genetic cause of autism and intellectual deficiency. In this paper, we describe the Phelan-McDermid Syndrome Data Network (PMS_DN), a platform that facilitates research into phenotype-genotype correlation and progression of PMS by: a) integrating knowledge of patient phenotypes extracted from Patient Reported Outcomes (PRO) data and clinical notes-two heterogeneous, underutilized sources of knowledge about patient phenotypes-with curated genetic information from the same patient cohort and b) making this integrated knowledge, along with a suite of statistical tools, available free of charge to authorized investigators on a Web portal https://pmsdn...
September 1, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28857542/ion-exchange-induced-selective-etching-for-the-synthesis-of-amino-functionalized-hollow-mesoporous-silica-for-elevated-high-temperature-fuel-cells
#14
Jin Zhang, Jian Liu, Shanfu Lu, Haijin Zhu, David Aili, Roland De Marco, Yan Xiang, Maria Forsyth, Qingfeng Li, San Ping Jiang
As differentiated from conventional synthetic processes, amino-functionalized hollow mesoporous silica (NH2-HMS) has been synthesized using a new and facile strategy of ion-exchange-induced selective etching of amino-functionalized mesoporous silica (NH2-meso-silica) by an alkaline solution. Nuclear magnetic resonance (NMR) spectroscopy and in situ time-resolved small-angle X-ray scattering (SAXS) reveal that ion-exchange-induced selective etching arises from the gradient distribution of OH(-) in the NH2-meso-silica nanospheres...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28851511/polypharmacy-potentially-inappropriate-medications-and-drug-drug-interactions-in-geriatric-patients-with-hematologic-malignancy-observational-single-center-study-of-122-patients
#15
David Y Leger, Stephane Moreau, Nicolas Signol, Jean-Baptiste Fargeas, Marie-Agnès Picat, Amélie Penot, Julie Abraham, Marie-Laure Laroche, Dominique Bordessoule
OBJECTIVES: Geriatric patients with hematologic malignancies (HMs) are prescribed targeted and supportive care treatments that add to the preexisting polypharmacy (PP). PP is associated with an increased risk of potentially inappropriate medications (PIM) and drug-drug interactions (DDI) resulting in increased hospitalization and mortality in the elderly. As very few data exist on these medication issues in the context of HMs, the objective of this study was to evaluate prevalence of PP, DDI and PIM use at baseline and 3months among elderly patients with HMs who received baseline geriatric assessment...
August 26, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28844708/osteopontin-and-their-roles-in-hematological-malignancies-splice-variants-on-the-new-avenues
#16
Ana Clara Santos Fonseca Bastos, Caroline Barbieri Blunck, Mariana Emerenciano, Etel Rodrigues Pereira Gimba
Osteopontin (OPN) is a protein expressed in several tissues, including bone marrow, in which it performs distinct roles, such as modulating hematopoietic stem cell niche and bone remodeling. Most data in hematological malignancies (HMs) refers to total OPN (tOPN), comprehending the sum of distinct OPN splicing isoforms (OPN-SI), while reports describing the expression and roles of each OPN-SI are scarce. This review aims to summarize tOPN roles in HMs and provide evidence that OPN-SIs can also modulate specific functions in HMs biology...
August 24, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28842363/associations-between-body-mass-index-across-adult-life-and-hip-shapes-at-age-60-to-64-evidence-from-the-1946-british-birth-cohort
#17
Stella G Muthuri, Fiona R Saunders, Rebecca J Hardy, Anastasia V Pavlova, Kathryn R Martin, Jennifer S Gregory, Rebecca J Barr, Judith E Adams, Diana Kuh, Richard M Aspden, Rachel Cooper
OBJECTIVE: To examine the associations of body mass index (BMI) across adulthood with hip shapes at age 60-64years. METHODS: Up to 1633 men and women from the MRC National Survey of Health and Development with repeat measures of BMI across adulthood and posterior-anterior dual-energy X-ray absorptiometry bone mineral density images of the proximal femur recorded at age 60-64 were included in analyses. Statistical shape modelling was applied to quantify independent variations in hip mode (HM), of which the first 6 were examined in relation to: i) BMI at each age of assessment; ii) BMI gain during different phases of adulthood; iii) age first overweight...
August 24, 2017: Bone
https://www.readbyqxmd.com/read/28841989/assessment-of-anti-inflammatory-properties-of-extracts-from-honeysuckle-lonicera-sp-l-caprifoliaceae-by-atr-ftir-spectroscopy
#18
R Nikzad-Langerodi, S Ortmann, E M Pferschy-Wenzig, V Bochkov, Y M Zhao, J H Miao, J Saukel, A Ladurner, E H Heiss, V M Dirsch, R Bauer, A G Atanasov
Inflammation is a hallmark of some of today's most life-threatening diseases such as arteriosclerosis, cancer, diabetes and Alzheimer's disease. Herbal medicines (HMs) are re-emerging resources in the fight against these conditions and for many of them, anti-inflammatory activity has been demonstrated. However, several aspects of HMs such as their multi-component character, natural variability and pharmacodynamic interactions (e.g. synergism) hamper identification of their bioactive constituents and thus the development of appropriate quality control (QC) workflows...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28820035/changes-in-heparin-dose-response-slope-during-cardiac-surgery-possible-result-in-inaccuracy-in-predicting-heparin-bolus-dose-requirement-to-achieve-target-act
#19
Junko Ichikawa, Tetsu Mori, Mitsuharu Kodaka, Keiko Nishiyama, Makoto Ozaki, Makiko Komori
INTRODUCTION: The substantial interpatient variability in heparin requirement has led to the use of a heparin dose response (HDR) technique. The accuracy of Hepcon-based heparin administration in achieving a target activated clotting time (ACT) using an HDR slope remains controversial. METHODS: We prospectively studied 86 adult patients scheduled for cardiac surgery requiring cardiopulmonary bypass. The total dose of calculated heparin required for patient and pump priming was administered simultaneously to achieve a target ACT of 450 s for HDR on the Hepcon HMS system...
September 2017: Perfusion
https://www.readbyqxmd.com/read/28819148/analysis-and-comparative-genomics-of-r997-the-first-sxt-r391-integrative-and-conjugative-element-ice-of-the-indian-sub-continent
#20
Michael P Ryan, Patricia Armshaw, John A O'Halloran, J Tony Pembroke
The aim of this study was to analyse R997, the first integrative and conjugative element (ICE) isolated from the Indian Sub-Continent, and to determine its relationship to the SXT/R391 family of ICEs. WGS of Escherichia coli isolate AB1157 (which contains R997) was performed using Illumina sequencing technology. R997 context was assessed by de novo assembly, gene prediction and annotation tools, and compared to other SXT/R391 ICEs. R997 has a size of 85 Kb and harbours 85 ORFs. Within one of the variable regions a HMS-1 β-lactamase resistance gene is located...
August 17, 2017: Scientific Reports
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