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Farrukh Ahmed, Asim-Bin-Zafar, Musarrat Riaz, Erum Ghafoor, Rabia Abdul Rehman, Qutub Uddin
OBJECTIVE: To evaluate the impact and effectiveness of 24-hour helpline service in providing information and educating patients about self-management of diabetes. METHOD: The study was conducted at Baqai Institute of Diabetology & Endocrinology (BIDE), a tertiary diabetes care center, Karachi, Pakistan. People with diabetes attending the outpatient department from November 2012 to October 2014 were included in this study. After providing diabetes education, a helpline number was provided for emergency situations...
May 2017: Pakistan Journal of Medical Sciences Quarterly
Amir Esmat Kaziem, Yunhao Gao, Shun He, Jianhong Li
In the present study, enzymatic responsive controlled release formulations (CRFs) were fabricated. The CRFs were achieved by anchoring mechanically interlocked molecules using α-cyclodextrin onto the surface pore rims of hollow mesoporous silica (HMS). The CRFs were characterized using Fourier transform infrared spectroscopy, scanning electron microscope, transmission electron microscope, and thermogravimetric analysis. The results showed that the CRFs had extraordinary loading ability for chlorantraniliprole (42% w/w) and could effectively preserve chlorantraniliprole against degradation under thermal conditions and UV radiation...
August 15, 2017: Journal of Agricultural and Food Chemistry
Erica T Warner, René Carapinha, Griffin M Weber, Emorcia V Hill, Joan Y Reede
OBJECTIVE: To determine whether there were gender differences in likelihood of receiving a first National Institutes of Health (NIH) R01 award among 5445 instructors and assistant professors at Harvard Medical School (HMS). MATERIALS AND METHODS: Data on R01 award principal investigators were obtained from NIH ExPORTER and linked with faculty data. Using Cox proportional hazard regression, we examined the association of gender with receipt of first R01 award between 2008 and 2015 accounting for demographics, research productivity metrics, and professional characteristics...
August 3, 2017: Journal of Women's Health
Wan-Yang Sun, Qin-Wei Lu, Hao Gao, Ling Tong, Dong-Xiang Li, Zheng-Qun Zhou, Zheng-Jin Jiang, Henry Sun, Kai-Shun Bi
Limitations in the separation ability of conventional liquid chromatography system remains a challenge in developing a versatile method for simultaneously determining both hydrophilic and lipophilic constituents in herbal medicines (HMs). To measure compounds covering a broad polarity span in HMs, we developed a directly-coupled reversed-phase and hydrophilic interaction liquid chromatography-tandem mass spectrometry system. Samples were firstly separated according to lipophilicity by using a C18 column. Utilizing a T-piece as connector, the eluent was then pumped into an amide column to get further separation that mainly based on the hydrogen bonding effects...
August 1, 2017: Scientific Reports
Enguo Ju, Kai Dong, Zhenzhen Wang, Yan Zhang, Fangfang Cao, Zhaowei Chen, Fang Pu, Jinsong Ren, Xiaogang Qu
Skin cancers caused by UV irradiation have been a major public health problem. One simple and effective way to avoid the above detrimental effects is the use of UV-protective sunscreens. However, there has been considerable concern with the issue of production of reactive oxygen species by the photo-degradation of commercial UV filters. Herein, we reported for the first time that the integration of ZnO nanoparticles and CeOx nanoparticles into hollow microspheres (ZnO/CeOx HMS) could provide broad UV spectrum protection and scavenge generated ROS under UV irradiation...
July 25, 2017: Chemistry: a European Journal
Guannan Liang, Bo Zhang, Mao Lin, Simiao Wu, Hao Hou, Jia Zhang, Guangren Qian, Xin Huang, Jizhi Zhou
The risk assessment code (RAC) is a common method for assessing heavy metal (HM) mobility and their potential health risks, based on HM total concentration and chemical speciation. In this study, both the RAC and the influence of ambient environmental factors were investigated in a river sediment system. Sixty-eight sediment samples were collected from the main river system in Shanghai, China. The total concentration and chemical speciation of Cu, Zn, Ni, Pb, Cd, Cr, As, and Hg were determined in the samples...
July 19, 2017: Science of the Total Environment
Beatriz González-Corrochano, Jacinto Alonso-Azcárate, Luis Rodríguez, Agripino Pérez Lorenzo, María Fernández Torío, Juan José Tejado Ramos, María Dolores Corvinos, Carlos Muro
The main objective of this paper was to study how effective thermal treatment is in the retention of different heavy metals (HMs) within the structure of artificial lightweight aggregates (LWAs). These LWAs were manufactured by washing aggregate sludge and sewage sludge. The consequence of increasing the heating dwell time whilst manufacturing these LWAs was also determined. Partitioning of the HMs (Cr, Ni, Cu, Zn, Cd and Pb) in both the waste raw materials and in the LWAs was studied by means of the optimized BCR sequential extraction procedure with lithium metaborate in the final fusion...
July 24, 2017: Environmental Technology
Angel Perez-Cruz, Ion Stiharu, Aurelio Dominguez-Gonzalez
In recent years paper-based microfluidic systems have emerged as versatile tools for developing sensors in different areas. In this work; we report a novel physical sensing principle for the characterization of liquids using a paper-based hygro-mechanical system (PB-HMS). The PB-HMS is formed by the interaction of liquid droplets and paper-based mini-structures such as cantilever beams. The proposed principle takes advantage of the hygroscopic properties of paper to produce hygro-mechanical motion. The dynamic response of the PB-HMS reveals information about the tested liquid that can be applied to characterize certain properties of liquids...
July 20, 2017: Sensors
Biagio Mandracchia, Vittorio Bianco, Zhe Wang, Martina Mugnano, Alessia Bramanti, Melania Paturzo, Pietro Ferraro
In the current trend of miniaturization and simplification of imaging flow cytometry, Lab-on-a-Chip (LoC) microfluidic devices represent an innovative and cost-effective solution. In this framework, we propose for the first time a novel platform based on the compactness of a holographic microscope slide (HMS) in combination with the new computational features of space-time digital holography (STDH) that uses a 1D linear sensor array (LSA) instead of 2D CCD or CMOS cameras to respond to real diagnostic needs...
August 8, 2017: Lab on a Chip
Yongmei Ma, Zhongmin Jia, Siyue Li
Assessment of heavy metal (HM) pollution in soil is critical for human health, ecological remediation, and soil conservation. In this study, statistical analyses and geochemical approaches such as enrichment factor (EF), the index of geoaccumulation (Igeo), and potential ecological risk index (RI) were used for characterization and risk assessment of soil HMs through a high-spatial-resolution 385 samples from Tongnan District, an important agricultural practice area in Chongqing Municipality in Southwest China...
July 13, 2017: Environmental Science and Pollution Research International
S J Wang, Z Y Sun, C Liu, P Yan, H Liang, K Huang, D G Wang, Y Li, J W Tian
Objective: To investigate the effect of high mechanical stretch stress(HMS)on human nucleus pulposus cells and its regulatory mechanism. Methods: The non-degenerated nucleus pulposus tissue (Pfirrmann<grade Ⅲ) removed from the patient's surgery was harvested and the human nucleus pulposus cells were isolated and cultured. In the presence or absence of pretreatment with the NF-κB specific blocker Bay11-7082, the cultured human nucleus pulposus cells were loaded cyclic mechanical stretch stress(CMS) with different parameters using the Flexercell system...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Yukun Ma, James McGree, An Liu, Kaveh Deilami, Prasanna Egodawatta, Ashantha Goonetilleke
Heavy metals (HMs) and polycyclic aromatic hydrocarbons (PAHs) are among the most toxic chemical pollutants present in urban stormwater. Consequently, urban stormwater reuse is constrained due to the human health risk posed by these pollutants. This study developed a scientifically robust approach to assess the risk to human health posed by HMs and PAHs in urban stormwater in order to enhance its reuse. Accordingly, an innovative methodology was created consisting of four stages: quantification of traffic and land use parameters; estimation of pollutant concentrations for model development; risk assessment, and risk map presentation...
July 6, 2017: Ecotoxicology and Environmental Safety
Claudia Hanson, Andrea B Pembe, Fadhlun Alwy, Susan Atuhairwe, Sebalda Leshabari, Jessica Morris, Frank Kaharuza, Gaetano Marrone
BACKGROUND: Postpartum haemorrhage complicates approximately 10% of all deliveries and contributes to at least a quarter of all maternal deaths worldwide. The competency-based Helping Mothers Survive Bleeding after Birth (HMS BAB) training was developed to support evidence-based management of postpartum haemorrhage. This one-day training includes low-cost MamaNatalie® birthing simulators and addresses both prevention and first-line treatment of haemorrhage. While evidence is accumulating that the training improves health provider's knowledge, skills and confidence, evidence is missing as to whether this translates into improved practices and reduced maternal morbidity and mortality...
July 6, 2017: Trials
Xiao-Kui Ma, Ting-Ting Li, Hala Farm, Eric Charles Peterson, Wei-Wei Zhao, Wenying Guo, Bo Zhou
Co-contamination of polycyclic aromatic hydrocarbons (PAHs) with heavy metals (HMs) in aquatic environments is a global threat, however, little is understood about PAH biodegradation in these sites. In this study, PAHs biodegradation in the presence of HMs in water by a metal tolerant consortium composed of Bacillus subtilis and fungus Acremonium sp. was investigated. The consortium demonstrated higher tolerance to the tested HMs (Fe(2+), Al(3+), Ni(2+), Cu(2+), Mn(2+), Zn(2+)) than the individual consortium components, and the tolerance to individual metals decreased with increasing metal concentrations...
July 5, 2017: Environmental Technology
Laura Monni, Filippo Ghezzi, Silvia Corsini, Andrea Nistri
Although propofol is a widely used intravenous general anaesthetic, many studies report its toxic potential, particularly on the developing central nervous system. We investigated its action on hypoglossal motoneurons (HMs) that control two critical functions in neonates, namely tongue muscle activity and airway patency. Thus, clinically relevant concentrations of propofol (1 and 5μM) were applied (4h) to neonatal rat brainstem slices to evaluate the expression of apoptosis-inducing factor (AIF) as biomarker of toxicity...
August 10, 2017: Neuroscience Letters
Guoxiang Xie, Shouli Wang, Hua Zhang, Aihua Zhao, Jiajian Liu, Yueming Ma, Ke Lan, Yan Ni, Changxiao Liu, Ping Liu, Tianlu Chen, Wei Jia
The advent of mass spectrometry based analytical technologies coupled with multivariate statistical methods offers tremendous new opportunities for understanding the pharmacokinetics (PK) of multicomponent herbal medicines (HMs). We recently proposed a Poly-PK strategy to characterize the concentration-time profile and the metabolic response profile of multicomponent HMs, using an integrated phytochemical and metabolomics approach. Here, we provided the first example of the Poly-PK strategy, where we simultaneously characterized the PK as well as the metabolic response profiles of a Chinese herbal medicine, Huangqi decoction (HQD, consisting of Radix Astragali and Radix Glycyrrhizae), in healthy Chinese volunteers...
July 4, 2017: Clinical Pharmacology and Therapeutics
Huihui Fang, Zhiqiang Liu, Yanping Long, Yali Liang, Zhuping Jin, Liping Zhang, Danmei Liu, Hua Li, Jixian Zhai, Yanxi Pei
Heavy metals (HMs) contamination on agricultural lands not only reduces crop yield but also causes human health concerns. As a plant gasotransmitter, hydrogen sulfide (H2 S) can trigger various defense responses and help reduce HMs accumulation in plants; however, little is known about the regulatory mechanisms of H2 S signaling. Here, we provided evidence to answer the long-standing question how H2 S production is elevated in plant defense against HMs stress. During Arabidopsis' response to chromium (Cr(6+) ) stress, the transcription of L-cysteine desulfhydrase (LCD), the key enzyme for H2 S production, was enhanced through the calcium (Ca(2+) )/calmodulin2 (CaM2)-mediated pathway...
July 3, 2017: Plant Journal: for Cell and Molecular Biology
A S Guerard, A Ayav, H Busby, M Lafitte, H Rousseau, V Laurent
PURPOSE: The aim of the present study was to estimate the incidence of very early hepatic metastases (HMs) (<6 months) and their imaging patterns after cephalic duodenopancreatectomy (CDP) for periampullary carcinoma (excluding duodenal carcinoma) and to identify their associated risk factors. METHODS: From January 2003 to June 2016, all patients who underwent surgical treatment for periampullary carcinoma by CDP at our institution and with adequate pre- and postoperative CT scans were included...
August 2017: European Journal of Radiology
Nwachukwu Ekere, Newman Yakubu, Janefrances Ihedioha
The concentrations of six heavy metals (HMs) and 16 US EPA priority polycyclic aromatic hydrocarbons (PAHs) in sediment samples of the confluence of rivers Niger and Benue were investigated. The ecological risk assessment of the contaminants was carried out. The results showed that the sediment samples were heavily polluted with iron and moderately polluted with Cd while other metals posed no pollution problem when compared with USEPA sediment quality guidelines. Only six out of the 16 priority PAHs were detected in the samples, and source apportionment of the PAHs indicated that they are of pyrogenic origin...
June 27, 2017: Environmental Science and Pollution Research International
Eric M Ammann, Matthew T Drake, Bjarni Haraldsson, Robert B Wallace, Karen C Johnson, Pinkal Desai, Emily M Lin, Brian K Link
BACKGROUND: Prior evidence of a possible link between vitamin D status and hematologic malignancy (HM) in humans comes from observational studies, leaving unresolved the question of whether a true causal relationship exists. METHODS: The authors performed a secondary analysis of data from the Women's Health Initiative Calcium/Vitamin D (CaD) trial, a large randomized controlled trial of CaD supplementation compared with placebo in older women. Kaplan-Meier and Cox proportional hazards survival analysis methods were used to evaluate the relationship between treatment assignment and 1) incident HM and 2) HM-specific mortality over 10 years following randomization...
June 27, 2017: Cancer
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