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https://www.readbyqxmd.com/read/29337422/hollow-mesoporous-silica-metal-organic-framework-and-its-applications-for-ph-responsive-doxorubicin-drug-delivery
#1
Xiaomin Jia, Zhiyuan Yang, Yujun Wang, Ya Chen, Haitao Yuan, Heyin Chen, Xiaoxiang Xu, Xueqing Gao, Zuozhong Liang, Yu Sun, Jian-Rong Li, Haoquan Zheng, Rui Cao
Metal-organic frameworks (MOFs), a new type of porous crystalline materials, have great potential in biomedical applications, such as drug delivery. However, the efficacy of drug delivery is limited by the low loading of drugs. We have synthesized hollow mesoporous silica (HMS)@MOF capsule that can be used as pH-responsive drug delivery system for anti-cancer drug doxorubicin (DOX). DOX is loaded into the inner cavity of HMS.Then, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles are coated on the outer surface of DOX loaded HMS...
January 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29323207/discovery-of-hepatotoxic-equivalent-combinatorial-markers-from-dioscorea-bulbifera-tuber-by-fingerprint-toxicity-relationship-modeling
#2
Wei Shi, Cai Zhang, Dongsheng Zhao, Lingli Wang, Ping Li, Huijun Li
Due to extremely chemical complexity, identification of potential toxicity-related constituents from an herbal medicine (HM) still remains challenging. Traditional toxicity-guided separation procedure suffers from time- and labor-consumption and neglects the additive effect of multi-components. In this study, we proposed a screening strategy called "hepatotoxic equivalent combinatorial markers (HECMs)" for a hepatotoxic HM, Dioscorea bulbifera tuber (DBT). Firstly, the chemical constituents in DBT extract were globally characterized...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319087/significant-enhancement-in-thermoelectric-performance-of-nanostructured-higher-manganese-silicides-synthesized-employing-a-melt-spinning-technique
#3
Saravanan Muthiah, R C Singh, B D Pathak, Piyush Kumar Avasthi, Rishikesh Kumar, Anil Kumar, A K Srivastava, Ajay Dhar
The limited thermoelectric performance of p-type Higher Manganese Silicides (HMS) in terms of their low figure-of-merit (ZT), which is far below unity, is the main bottle-neck for realising an efficient HMS based thermoelectric generator, which has been recognized as the most promising material for harnessing waste-heat in the mid-temperature range, owing to its thermal stability, earth-abundant and environmentally friendly nature of its constituent elements. We report a significant enhancement in the thermoelectric performance of nanostructured HMS synthesized using rapid solidification by optimizing the cooling rates during melt-spinning followed by spark plasma sintering of the resulting melt-spun ribbons...
January 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29302912/development-of-an-indicator-for-characterizing-particle-size-distribution-and-quality-of-stormwater-runoff
#4
Qian Wang, Qionghua Zhang, Mawuli Dzakpasu, Bin Lian, Yaketon Wu, Xiaochang C Wang
Stormwater particles washed from road-deposited sediments (RDS) are traditionally characterized as either turbidity or total suspended solids (TSS). Although these parameters are influenced by particle sizes, neither of them characterizes the particle size distribution (PSD), which is of great importance in pollutant entrainment and treatment performance. Therefore, the ratio of turbidity to TSS (Tur/TSS) is proposed and validated as a potential surrogate for the bulk PSD and quality of stormwater runoff. The results show an increasing trend of Tur/TSS with finer sizes of both RDS and stormwater runoff...
January 5, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29302118/blood-and-blood-product-conservation-results-of-strategies-to-improve-clinical-outcomes-in-open-heart-surgery-patients-at-a-tertiary-hospital
#5
Junaid H Khan, Emily A Green, Jimmin Chang, Alexandria M Ayala, Marilyn S Barkin, Emily E Reinys, Jeffrey Stanton, Russell D Stanten
Blood product usage is a quality outcome for patients undergoing cardiac surgery. To address an increase in blood product usage since the discontinuation of aprotinin, blood conservation strategies were initiated at a tertiary hospital in Oakland, CA. Improving transfusion rates for open heart surgery patients requiring Cardiopulmonary bypass (CPB) involved multiple departments in coordination. Specific changes to conserve blood product usage included advanced CPB technology upgrades, and precise individualized heparin dose response titration assay for heparin and protamine management...
December 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/29300414/distinct-interface-behaviors-of-ni-ii-on-graphene-oxide-and-oxidized-carbon-nanotubes-triggered-by-different-topological-aggregations
#6
Jianjun Liang, Ping Li, Xiaolan Zhao, Ziyi Liu, Qiaohui Fan, Zhan Li, Jiaxing Li, Dongqi Wang
Although carbon nanotubes can be described as a seamlessly curled graphene nanosheet, two-dimensional graphene oxide (GO) and one-dimensional oxidized carbon nanotubes (OCNTs) have different fates and environmental risks, such as deposition, degradation and cytotoxicity. In particular, coexisting heavy metal ions (HMs) trigger distinct morphological transformations of both of these carbon derivatives. In addition, these morphological transformations can change the interface behaviors of HMs on both of these materials...
January 4, 2018: Nanoscale
https://www.readbyqxmd.com/read/29296490/detection-of-optical-activity-with-diode-integrated-hyperbolic-metasurfaces
#7
Joseph S T Smalley, Felipe Vallini, Yeshaiahu Fainman
We present an analytical technique for designing integrated polarized light-emitting diodes (LEDs) and polarization-sensitive photodiodes (PD) based on hyperbolic metasurfaces (HMS) for the detection of optical activity. Leveraging effective medium theory and the scattering matrix method, we first derive the conditions for optimizing the transmission efficiency of an LED-integrated HMS and the absorption efficiency of a PD-integrated HMS. We then propose using a differential detection technique with orthogonally oriented PD-integrated HMS to measure optical activity in an extremely compact volume...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29286619/comparison-of-diagnostic-yield-of-a-fish-panel-against-conventional-cytogenetic-studies-for-hematological-malignancies-a-south-indian-referral-laboratory-analysis-of-201-cases
#8
Vishal Ashok, Ramya Ranganathan, Smitha Chander, Sharat Damodar, Sunil Bhat, Nataraj K S, Satish Kumar A, Sachin Suresh Jadav, Mahesh Rajashekaraiah, Sundareshan T S
Objectives: Genetic markers are crucial fort diagnostic and prognostic investigation of hematological malignancies (HM). The conventional cytogenetic study (CCS) has been the gold standard for more than five decades. However, FISH (Fluorescence in Situ Hybridization) testing has become a popular modality owing to its targeted approach and the ability to detect abnormalities in non-mitotic cells. We here aimed to compare the diagnostic yields of a FISH panel against CCS in HMs. Methods: Samples of bone marrow and peripheral blood for a total of 201 HMs were tested for specific gene rearrangements using multi-target FISH and the results were compared with those from CCS...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29277319/two-mulberry-phytochelatin-synthase-genes-confer-zinc-cadmium-tolerance-and-accumulation-in-transgenic-arabidopsis-and-tobacco
#9
Wei Fan, Qing Guo, ChangYing Liu, Xueqin Liu, Meng Zhang, Dingpei Long, Zhonghuai Xiang, Aichun Zhao
Phytochelatin synthase (PCS) is an enzyme involved in the synthesis of phytochelatins, cysteine-rich peptides which play a key role in heavy metal (HM) detoxification of plants. Mulberry (Morus L.), one of the most ecologically and economically important tree genera, has the potential to remediate HM-contaminated soils. However, genes involved in HM detoxification in Morus, such as the PCS genes, have not been identified and characterized. In this study, we identified two Morus notabilis PCS genes based on a genome-wide analysis of the Morus genome database...
December 22, 2017: Gene
https://www.readbyqxmd.com/read/29260336/development-of-a-hec-hms-based-watershed-modeling-system-for-identification-allocation-and-optimization-of-reservoirs-in-a-river-basin
#10
R Srinivas, Ajit Pratap Singh, Anirban Deshmukh
One of the primary objectives of river basin planning and management is to assess the behavior of the river towards man-made and natural changes. In recent times, the self-purifying capacity of the river is found to be substantially affected because of extensive use of water for agricultural and industrial purposes. Any variation in the flow regime of a river poses a severe impact on the aquatic ecosystem, which affects its self-purifying capacity. Diverting river water for industrial and agricultural uses through dams and barrages reduces the natural flow rate of the river...
December 19, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29259849/genome-wide-characterization-and-expression-profiling-of-nac-transcription-factor-genes-under-abiotic-stresses-in-radish-raphanus-sativus-l
#11
Bernard Kinuthia Karanja, Liang Xu, Yan Wang, Everlyne M'mbone Muleke, Bashir Mohammed Jabir, Yang Xie, Xianwen Zhu, Wanwan Cheng, Liwang Liu
NAC (NAM, no apical meristem; ATAF, Arabidopsis transcription activation factor and CUC, cup-shaped cotyledon) proteins are among the largest transcription factor (TF) families playing fundamental biological processes, including cell expansion and differentiation, and hormone signaling in response to biotic and abiotic stresses. In this study, 172 RsNACs comprising 17 membrane-bound members were identified from the whole radish genome. In total, 98 RsNAC genes were non-uniformly distributed across the nine radish chromosomes...
2017: PeerJ
https://www.readbyqxmd.com/read/29241441/antibody-separation-using-lectin-modified-poly-hema-edma-hydrogel-membranes
#12
Esra Feyzioğlu Demir, Cansu Ilke Kuru, Murat Uygun, Deniz Aktaş Uygun, Sinan Akgöl
Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the as-synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10...
December 15, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29228186/aether-leveraging-linear-programming-for-optimal-cloud-computing-in-genomics
#13
Jacob M Luber, Braden T Tierney, Evan M Cofer, Chirag J Patel, Aleksandar D Kostic
Motivation: Across biology we are seeing rapid developments in scale of data production without a corresponding increase in data analysis capabilities. Results: Here, we present Aether (http://aether.kosticlab.org), an intuitive, easy-to-use, cost-effective, and scalable framework that uses linear programming (LP) to optimally bid on and deploy combinations of underutilized cloud computing resources. Our approach simultaneously minimizes the cost of data analysis and provides an easy transition from users' existing HPC pipelines...
December 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29228172/spring-a-kinetic-interface-for-visualizing-high-dimensional-single-cell-expression-data
#14
Caleb Weinreb, Samuel Wolock, Allon Klein
Motivation: Single-cell gene expression profiling technologies can map the cell states in a tissue or organism. As these technologies become more common, there is a need for computational tools to explore the data they produce. In particular, visualizing continuous gene expression topologies can be improved, since current tools tend to fragment gene expression continua or capture only limited features of complex population topologies. Results: Force-directed layouts of k-nearest-neighbor graphs can visualize continuous gene expression topologies in a manner that preserves high-dimensional relationships and captures complex population topologies...
December 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29204589/hyoid-myotomy-and-suspension-without-simultaneous-palate-or-tongue-base-surgery%C3%A2-for-obstructive-sleep-apnea
#15
Adrian A Ong, Jonathan Buttram, Shaun A Nguyen, Dustin Platter, Michael R Abidin, M Boyd Gillespie
Objective: Determine the effects of hyoid myotomy and suspension (HMS) without concurrent palatal or tongue base sleep surgery for obstructive sleep apnea (OSA). Method: Patients with OSA treated with HMS were identified using CPT code (21685) at an academic and private sleep surgery clinic. Those who underwent concurrent palatal or tongue base sleep surgery were excluded. Outcomes included simultaneous procedures, apnea-hypopnea index (AHI), lowest oxyhemoglobin saturation (LSAT), and Epworth Sleepiness Scale (ESS)...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29186292/satori-a-system-for-ontology-guided-visual-exploration-of-biomedical-data-repositories
#16
Fritz Lekschas, Nils Gehlenborg
Motivation: The ever-increasing number of biomedical data sets provides tremendous opportunities for re-use but current data repositories provide limited means of exploration apart from text-based search. Ontological metadata annotations provide context by semantically relating data sets. Visualizing this rich network of relationships can improve the explorability of large data repositories and help researchers find data sets of interest. Results: We developed SATORI -an integrative search and visual exploration interface for the exploration of biomedical data repositories...
November 23, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29155944/molecular-interaction-search-tool-mist-an-integrated-resource-for-mining-gene-and-protein-interaction-data
#17
Yanhui Hu, Arunachalam Vinayagam, Ankita Nand, Aram Comjean, Verena Chung, Tong Hao, Stephanie E Mohr, Norbert Perrimon
Model organism and human databases are rich with information about genetic and physical interactions. These data can be used to interpret and guide the analysis of results from new studies and develop new hypotheses. Here, we report the development of the Molecular Interaction Search Tool (MIST; http://fgrtools.hms.harvard.edu/MIST/). The MIST database integrates biological interaction data from yeast, nematode, fly, zebrafish, frog, rat and mouse model systems, as well as human. For individual or short gene lists, the MIST user interface can be used to identify interacting partners based on protein-protein and genetic interaction (GI) data from the species of interest as well as inferred interactions, known as interologs, and to view a corresponding network...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29153474/impacts-of-environmental-factors-on-the-whole-microbial-communities-in-the-rhizosphere-of-a-metal-tolerant-plant-elsholtzia-haichowensis-sun
#18
Songqiang Deng, Tan Ke, Longtai Li, Shenwen Cai, Yuyue Zhou, Yue Liu, Limin Guo, Lanzhou Chen, Dayi Zhang
Rhizospheric microbes play important roles in plant growth and heavy metals (HMs) transformation, possessing great potential for the successful phytoremediation of environmental pollutants. In the present study, the rhizosphere of Elsholtzia haichowensis Sun was comprehensively studied to uncover the influence of environmental factors (EFs) on the whole microbial communities including bacteria, fungi and archaea, via quantitative polymerase chain reaction (qPCR) and high-throughput sequencing. By analyzing molecular ecological network and multivariate regression trees (MRT), we evaluated the distinct impacts of 37 EFs on soil microbial community...
November 15, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29136606/heavy-metals-in-soils-of-hechuan-county-in-the-upper-yangtze-sw-china-comparative-pollution-assessment-using-multiple-indices-with-high-spatial-resolution-sampling
#19
Maofei Ni, Rong Mao, Zhongmin Jia, Ruozhu Dong, Siyue Li
In order to assess heavy metals (HMs) in soils of the upper Yangtze Basin, a very high-spatial-resolution sampling (582 soil samples) was conducted from Hechuan County, an important agricultural practice area in the Southwest China. Multiple indices including geoaccumulation index (Igeo), enrichment factor (EF), sediment pollution index (SPI) and risk index (RI), as well as multivariate statistics were employed for pollution assessment and source identification of HMs in soils. Our results demonstrated that the averages of eight HMs decreased in the following order: Zn (82...
November 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29123678/rare-earth-based-quaternary-heusler-compounds-mcovz-m-lu-y-z-si-ge-with-tunable-band-characteristics-for-potential-spintronic-applications
#20
Xiaotian Wang, Zhenxiang Cheng, Guodong Liu, Xuefang Dai, Rabah Khenata, Liying Wang, Abdelmadjid Bouhemadou
Magnetic Heusler compounds (MHCs) have recently attracted great attention since these types of material provide novel functionalities in spintronic and magneto-electronic devices. Among the MHCs, some compounds have been predicted to be spin-filter semiconductors [also called magnetic semiconductors (MSs)], spin-gapless semiconductors (SGSs) or half-metals (HMs). In this work, by means of first-principles calculations, it is demonstrated that rare earth-based equiatomic quaternary Heusler (EQH) compounds with the formula MCoVZ (M = Lu, Y; Z = Si, Ge) are new spin-filter semiconductors with total magnetic moments of 3 µB...
November 1, 2017: IUCrJ
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