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https://www.readbyqxmd.com/read/28532158/particulate-matter-heavy-metals-and-polycyclic-aromatic-hydrocarbons-accumulation-on-the-leaves-of-tilia-cordata-mill-in-five-polish-cities-with-different-level-of-air-pollution
#1
Robert Popek, Adrian Łukowski, Christopher Bates, Jacek Oleksyn
Urbanized areas are struggling with the problem of air pollution and when the number of people living in cities increasing, the situation is likely to deteriorate. One of the most harmful pollutants is particulate matter (PM). Increased levels of PM in the atmosphere are likely to have a negative impact on human health. Phytoremediation technology could be a solution. It involves plants acting as bio-filters by accumulating particles on, and in the leaves, which removes the particles from the atmosphere.This study looks at the accumulation of PM including heavy metals (HMs) and polycyclic aromatic hydrocarbons (PAHs), on the foliage of small-leaved lime (Tilia cordata Mill...
May 22, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28529947/immune-checkpoint-blockade-for-hematologic-malignancies-a-review
#2
REVIEW
Matthew J Pianko, Yuzhou Liu, Srishti Bagchi, Alexander M Lesokhin
Immune checkpoint blockade has revolutionized the treatment of cancer, with impressive responses seen in a broad variety of tumor types. Blockade of immune checkpoints and immune signaling antibodies has shown promise in multiple types of hematologic malignancies (HMs), with dramatic single agent responses for pembrolizumab and nivolumab in Hodgkin lymphoma (HL). In this review, we outline the current state of immune checkpoint blockade drug development in HMs, and discuss mechanisms of activity and resistance, and highlight potential targets in the immune tumor microenvironment (TME)...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28520900/accelerating-high-dimensional-clustering-with-lossless-data-reduction
#3
Bahjat F Qaqish, Jonathon J O'Brien, Jonathan C Hibbard, Katie J Clowers
Motivation: For cluster analysis, high dimensional data is associated with instability, decreased classification accuracy and high computational burden. The latter challenge can be eliminated as a serious concern. For applications where dimension reduction techniques are not implemented, we propose a temporary transformation which accelerates computations with no loss of information. The algorithm can be applied for any statistical procedure depending only on Euclidean distances and can be implemented sequentially to enable analyses of data that would otherwise exceed memory limitations...
May 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28498654/template-mediated-ni-ii-dispersion-in-mesoporous-sio2-for-preparation-of-highly-dispersed-ni-catalysts-influence-of-template-type
#4
Xin Ning, Yiyuan Lu, Heyun Fu, Haiqin Wan, Zhaoyi Xu, Shourong Zheng
Supported Ni catalysts on three mesoporous SiO2 supports (e.g. SBA-15, MCM-41 and HMS) were prepared by a solid state reaction between Ni(NO3)2 and organic template occluded mesoporous SiO2. For comparison, supported Ni catalysts on mesoporous SiO2 prepared by the conventional impregnation method were also included. The catalysts were characterized by scanning electron microscope, X-ray diffraction, UV-Vis diffuse reflectance spectroscopy, N2 adsorption, X-ray photoelectron spectroscopy, H2 temperature-programmed reduction, transmission electron microscopy, and transmission electron microscopy-energy dispersive X-ray...
May 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28498125/examining-the-effects-of-urban-agglomeration-polders-on-flood-events-in-qinhuai-river-basin-china-with-hec-hms-model
#5
Yuqin Gao, Yu Yuan, Huaizhi Wang, Arthur R Schmidt, Kexuan Wang, Liu Ye
The urban agglomeration polders type of flood control pattern is a general flood control pattern in the eastern plain area and some of the secondary river basins in China. A HEC-HMS model of Qinhuai River basin based on the flood control pattern was established for simulating basin runoff, examining the impact of urban agglomeration polders on flood events, and estimating the effects of urbanization on hydrological processes of the urban agglomeration polders in Qinhuai River basin. The results indicate that the urban agglomeration polders could increase the peak flow and flood volume...
May 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28496451/genome-wide-identification-of-histone-modifiers-and-their-expression-patterns-during-fruit-abscission-in-litchi
#6
Manjun Peng, Peiyuan Ying, Xuncheng Liu, Caiqin Li, Rui Xia, Jianguo Li, Minglei Zhao
Modifications to histones, including acetylation and methylation processes, play crucial roles in the regulation of gene expression in plant development as well as in stress responses. However, limited information on the enzymes catalyzing histone acetylation and methylation in non-model plants is currently available. In this study, several histone modifier (HM) types, including six histone acetyltransferases (HATs), 11 histone deacetylases (HDACs), 48 histone methyltransferases (HMTs), and 22 histone demethylases (HDMs), are identified in litchi (Litchi chinensis Sonn...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28486473/an-activity-integrated-strategy-of-the-identification-screening-and-determination-of-potential-neuraminidase-inhibitors-from-radix-scutellariae
#7
Wei Liu, Huilin Wang, Bo Zhu, Chengqian Yin, Shuyang Chen, Jin Li, Xie-An Yu, John Teye Azietaku, Mingrui An, Xiu-Mei Gao, Yan-Xu Chang
Small molecules isolated from herbal medicines (HMs) were identified as the potential neuraminidase inhibitors which are effective in influenza prevention and treatment. Unfortunately, current available screen methods of small molecules isolated from HMs are inefficient and insensitive. Here a novel Ultra Performance Liquid Chromatography coupled with diode-array detectors and auto-fraction collector / time-of-flight mass spectrometry (UPLC-DAD-FC/Q-TOF-MS) screening method with high efficiency was developed and validated to separate, collect, enrich, identify and quantify potential neuraminidase inhibitors from Radix Scutellariae...
2017: PloS One
https://www.readbyqxmd.com/read/28462140/effectiveness-and-safety-of-combination-treatment-of-herbal-medicines-and-oral-antihistamines-for-atopic-dermatitis-a-retrospective-chart-review
#8
Younghee Yun, Jaewoong Son, Kyuseok Kim, Bo-Hyeong Jang, Inhwa Choi, Seong-Gyu Ko
BACKGROUND: Patients with atopic dermatitis (AD) exhibit various symptoms, especially itching. Recently, herbal medicines (HMs) are being used in combination with antihistamines for the treatment of AD in Korea. While oral antihistamines can alleviate itching, HMs appear to exert anti-inflammatory effects with minimal side effects. However, there is little evidence regarding the effectiveness and safety of using HMs in combination with antihistamines for AD. METHODS: To observe the effectiveness and safety of combination treatment with HMs and antihistamines, we performed a retrospective chart review of inpatients with AD who received this combination treatment for at least 7 days in a hospital...
March 2017: Integr Med Res
https://www.readbyqxmd.com/read/28459617/outpatient-closed-loop-control-with-unannounced-moderate-exercise-in-adolescents-using-zone-model-predictive-control
#9
Lauren M Huyett, Trang T Ly, Gregory P Forlenza, Suzette Reuschel-DiVirgilio, Laurel H Messer, R Paul Wadwa, Ravi Gondhalekar, Francis J Doyle, Jordan E Pinsker, David M Maahs, Bruce A Buckingham, Eyal Dassau
BACKGROUND: The artificial pancreas (AP) has the potential to improve glycemic control in adolescents. This article presents the first evaluation in adolescents of the Zone Model Predictive Control and Health Monitoring System (ZMPC+HMS) AP algorithms, and their first evaluation in a supervised outpatient setting with frequent exercise. MATERIALS AND METHODS: Adolescents with type 1 diabetes underwent 3 days of closed-loop control (CLC) in a hotel setting with the ZMPC+HMS algorithms on the Diabetes Assistant platform...
May 1, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28456602/an-update-on-nitric-oxide-and-its-benign-role-in-plant-responses-under-metal-stress
#10
REVIEW
Seema Sahay, Meetu Gupta
Pollution due to heavy metal(loid)s has become common menace across the globe. This is due to unprecedented frequent geological changes coupled with increasing anthropogenic activities, and population growth rate. Heavy metals (HMs) presence in the soil causes toxicity, and hampers plant growth and development. Plants being sessile are exposed to a variety of stress and/or a network of different kinds of stresses throughout their life cycle. To sense and transduce these stress signal, the signal reactive nitrogen species (RNS) particularly nitric oxide (NO) is an important secondary messenger next to only reactive oxygen species (ROS)...
April 26, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28454434/f10-a-novel-hydatidiform-mole-associated-gene-inhibits-the-paclitaxel-sensitivity-of-a549-lung-cancer-cells-by-downregulating-bax-and-caspase-3
#11
Yali Song, Wei Cao, Xi Zhu, Zhuolin Qiu, Xiaoping Yang, Jing Liu, Ruoting Xu, Weizhuang Yuan, Song Quan
F10 is a novel hydatidiform mole (HM)-associated gene that was initially identified during a study into the pathogenesis of HMs. However, the role of the F10 gene requires further investigation. Our, previous studies have indicated that F10 may be involved in the malignant transformation of HMs and the development of certain types of adenocarcinoma, and that the overexpression of F10 may lead to excessive proliferation and decreased apoptosis of A549 cells. The present study aimed to investigate whether F10 may suppress the sensitivity of A549 lung cancer cells to paclitaxel therapy...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28427550/home-made-spacer-as-an-auxiliary-device-in-administration-of-beclomethasone-via-pressurized-metered-dose-inhaler-for-asthma-control-a-randomized-controlled-pragmatic-trial
#12
Deborah Schor, José Ângelo Rizzo, Decio Medeiros, Ana Carolina Dela Bianca, Almerinda Rego Silva, Carlos Nunes, Mário Morais-Almeida, Emanuel Sarinho
BACKGROUND: Holding chambers or spacers can enhance the efficacy of pressurized metered dose inhalers (pMDI) in delivering inhaled medications, as they reduce the need for hand-breath coordination and improve lower airways deposition. Nevertheless, their cost can be high for patients in low-income countries. OBJECTIVE: To compare asthma control achieved with beclomethasone-dipropionate administered through a hydrofluoroalkane-driven pMDI (BDp-pMDI) coupled to a home-made spacer (HmS) or to a valved commercial spacer (VCS) as auxiliary devices...
May 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28408188/investigation-and-risk-evaluation-of-the-occurrence-of-carbamazepine-oxcarbazepine-their-human-metabolites-and-transformation-products-in-the-urban-water-cycle
#13
Elena Brezina, Carsten Prasse, Johannes Meyer, Harald Mückter, Thomas A Ternes
Trace organic contaminants such as pharmaceuticals, personal care products and industrial chemicals are frequently detected in the urban water cycle, including wastewater, surface water and groundwater, as well as drinking water. These also include human metabolites (HMs), which are formed in the human body and then excreted via urine or feces, as well as transformation products (TPs) formed in engineered treatment systems and the aquatic environment. In the current study, the occurrence of HMs as well as their TPs of the anticonvulsants carbamazepine (CBZ) and oxcarbazepine (OXC) were investigated using LC tandem MS in effluents of wastewater treatment plants (WWTPs), surface water and groundwater...
April 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28397062/multi-metal-resistance-and-plant-growth-promotion-potential-of-a-wastewater-bacterium-pseudomonas-aeruginosa-and-its-synergistic-benefits
#14
Jayanta Kumar Biswas, Monojit Mondal, Jörg Rinklebe, Santosh Kumar Sarkar, Punarbasu Chaudhuri, Mahendra Rai, Sabry M Shaheen, Hocheol Song, Muhammad Rizwan
Water and soil pollution by toxic heavy metals (HMs) is increasing globally because of increase in population, industrialization and urbanization. It is a burning problem for the public, scientists, academicians and politicians how to tackle the toxic contaminants which jeopardize the environment. One possible solution for pollution abatement is a bioremediation-effective and innovative technology that uses biological systems for treatment of contaminants. Many bacteria synthesize indole-3-acetic acid (IAA) which is a product of L-tryptophan metabolism and belongs to the auxin class of plant growth-promoting hormone...
April 10, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28353172/dodecylamine-template-based-hexagonal-mesoporous-silica-hms-as-a-carrier-for-improved-oral-delivery-of-fenofibrate
#15
Nitin V Jadhav, Pradeep R Vavia
The aim of present investigation was the preparation of dodecylamine template-based hexagonal mesoporous silica (HMS) as a carrier for poorly water-soluble drug (fenofibrate). HMS material has distinctive characteristics such as easy synthesis, high surface area and wormhole pores. These characteristics are highly admirable to make use of it as a carrier in drug delivery system. HMS was prepared by pH and temperature-independent process. Fenofibrate was loaded into the HMS by solvent immersion method using organic solvent...
March 28, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28337282/chronic-intermittent-hypoxia-affects-endogenous-serotonergic-inputs-and-expression-of-synaptic-proteins-in-rat-hypoglossal-nucleus
#16
Xu Wu, Huan Lu, Lijuan Hu, Wankun Gong, Juan Wang, Cuiping Fu, Zilong Liu, Shanqun Li
Evidence has shown that hypoxic episodes elicit hypoglossal neuroplasticity which depends on elevated serotonin (5-HT), in contrast to the rationale of obstructive sleep apnea (OSA) that deficient serotonergic input to HMs fails to keep airway patency. Therefore, understanding of the 5-HT dynamic changes at hypoglossal nucleus (HN) during chronic intermittent hypoxia (CIH) will be essential to central pathogenic mechanism and pharmacological therapy of OSA. Moreover, the effect of CIH on BDNF-TrkB signaling proteins was quantified in an attempt to elucidate cellular cascades/synaptic mechanisms following 5-HT alteration...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28298368/building-a-new-life-in-australia-an-analysis-of-the-first-wave-of-the-longitudinal-study-of-humanitarian-migrants-in-australia-to-assess-the-association-between-social-integration-and-self-rated-health
#17
Wen Chen, Li Ling, Andre M N Renzaho
OBJECTIVES: To assess the relationship between social integration and physical and mental health among humanitarian migrants (HMs) in Australia. DESIGN, SETTING AND PARTICIPANTS: We used the recently released first wave of data from the 2013 'Building a New Life in Australia' survey, which is an ongoing nationwide longitudinal study. A total of 2399 HMs participated in the survey. MAIN OUTCOME MEASURES: Self-rated physical health was measured using four items selected from the SF-36 which is a generic measure of health status...
March 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28291495/an-assessment-of-national-emt-certification-among-enlisted-military-medics
#18
Stephen Harper, Remle Crowe, Melissa Bentley, Chetan Kharod, Benjamin Walrath
BACKGROUND: Navy Hospital Corpsmen (HMs) are the Navy equivalent to Emergency Medical Technicians (EMTs) both in-garrison and on the battlefield. In 2000, the Emergency Medical Services (EMS) Education Agenda for the Future highlighted the need for a single certification agency to provide consistent evaluation of entry level competence for each nationally recognized EMS provider level. Administered by the National Registry of EMTs (NREMT), National EMT Certification is currently utilized by 46 states, the District of Columbia, four territories, and six federal organizations as part of their processes for granting licensure...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28255819/the-ecological-risk-source-identification-and-pollution-assessment-of-heavy-metals-in-road-dust-a-case-study-in-rafsanjan-se-iran
#19
Milad Mirzaei Aminiyan, Mohammed Baalousha, Rouhollah Mousavi, Farzad Mirzaei Aminiyan, Hamideh Hosseini, Amin Heydariyan
Heavy metal (HM) contamination in road dust is a potential environmental and human health threat. The sources, concentrations, spatial distribution, and ecological risk of As, Cd, Cu, Cr, Ni, Pb, and Zn in road dust in Rafsanjan City, Iran, were investigated. Pollution was assessed using the enrichment factor (EF). The potentially harmful effects of HMs were evaluated by calculating the potential ecological risk factor of individual metals (E r ) and of multiple metals (RI) using the Hakanson method. Correlation and principal component analyses (PCA) were applied to identify HM pollution sources...
March 2, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28243325/interferon-regulatory-factor-7-promoted-glioblastoma-progression-and-stemness-by-modulating-il-6-expression-in-microglia
#20
Zongze Li, Qiming Huang, Heping Chen, Zhiqin Lin, Meng Zhao, Zhongli Jiang
BACKGROUND: Interferon Regulatory Factor 7 (IRF7) is associated with chronic inflammation initiated by the activation of microglia. However it remains poorly defined how IRF7 activates microglia to initiate inflammatory microenvironment, and thus promotes the growth and malignancy of glioblastoma multiforme (GBM). This study investigated the role of IRF7 expression in microglia which increases GBM progression. METHODS: We established stable human microglia (HMs) over-expressing IRF-7 or empty vector by lentiviral transduction and stable selection...
2017: Journal of Cancer
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