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https://www.readbyqxmd.com/read/28213706/plant-microbial-association-in-petroleum-and-gas-exploration-sites-in-the-state-of-assam-north-east-india-significance-for-bioremediation
#1
Hemen Sarma, N F Islam, M N V Prasad
The state of Assam in north-east India gained popularity in Asia because of discovery of oil. Pollution due to petroleum and gas exploration is a serious problem in Assam. Oil and gas exploration by various agencies in Assam resulted in soil pollution due to hydrocarbons (HCs) and heavy metals (HMs). Bioremediation gained considerable significance in addressing petroleum hydrocarbon polluted sites in various parts of the world. In this investigation, we have observed 15 species of plants belonging to grass growing on the contaminated soils...
February 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28191470/effects-of-a-novel-glucokinase-activator-hms5552-on-glucose-metabolism-in-a-rat-model-of-type-2-diabetes-mellitus
#2
Ping Wang, Huili Liu, Li Chen, Yingli Duan, Qunli Chen, Shoumin Xi
Glucokinase (GK) plays a critical role in the control of whole-body glucose homeostasis. We investigated the possible effects of a novel glucokinase activator (GKA), HMS5552, to the GK in rats with type 2 diabetes mellitus (T2DM). Male Sprague-Dawley (SD) rats were divided into four groups: control group, diabetic group, low-dose (10 mg/kg) HMS5552-treated diabetic group (HMS-L), and high-dose (30 mg/kg) HMS5552-treated diabetic group (HMS-H). HMS5552 was administered intragastrically to the T2DM rats for one month...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28183098/sponges-of-the-guyana-shelf
#3
Rob W M VAN Soest
Sponges collected on the Guyana Shelf, predominantly in Suriname offshore waters, by Dutch HMS 'Snellius' O.C.P.S. 1966, HMS 'Luymes' O.C.P.S. II 1969, and HMS 'Luymes' Guyana Shelf 1970 expeditions are described in this study. Sponges were obtained by trawling, dredging or grabbing on sandy, muddy, shelly, and fossil reef bottoms at 88 stations between 19 and 681 m depth. A total of 351 samples were identified to species level, each consisting of one or more specimens of a given species from each individual station (together comprising 547 individuals and fragments)...
January 12, 2017: Zootaxa
https://www.readbyqxmd.com/read/28178369/burden-of-human-metapneumovirus-infections-in-patients-with-cancer-risk-factors-and-outcomes
#4
Firas El Chaer, Dimpy P Shah, Joumana Kmeid, Ella J Ariza-Heredia, Chitra M Hosing, Victor E Mulanovich, Roy F Chemaly
BACKGROUND: Human metapneumovirus (hMPV) causes upper and lower respiratory tract infections (URIs and LRIs, respectively) in healthy and immunocompromised patients; however, its clinical burden in patients with cancer remains unknown. METHODS: In a retrospective study of all laboratory-confirmed hMPV infections treated at the authors' institution between April 2012 and May 2015, clinical characteristics, risk factors for progression to an LRI, treatment, and outcomes in patients with cancer were determined...
February 8, 2017: Cancer
https://www.readbyqxmd.com/read/28160703/spatial-distribution-and-risk-assessment-of-heavy-metals-in-soil-near-a-pb-zn-smelter-in-feng-county-china
#5
Feng Shen, Renmei Liao, Amjad Ali, Amanullah Mahar, Di Guo, Ronghua Li, Sun Xining, Mukesh Kumar Awasthi, Quan Wang, Zengqiang Zhang
A large scale survey and a small scale continuous monitoring was conducted to evaluate the impact of Pb/Zn smelting on soil heavy metals (HMs) accumulation and potential ecological risk in Feng County, Shaanxi province of China. Soil parameters including pH, texture, CEC, spatial and temporal distribution of HMs (Cd, Cu, Ni, Pb and Zn), and BCR fractionation were monitored accordingly. The results showed the topsoil in the proximity of smelter, especially the smelter area and county seat, were highly polluted by HMs in contrast to the river basins...
February 1, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28144917/impact-of-adalimumab-on-work-productivity-and-activity-impairment-in-japanese-patients-with-rheumatoid-arthritis-large-scale-prospective-single-cohort-anouveau-study
#6
Tsutomu Takeuchi, Ryo Nakajima, Shuichi Komatsu, Kiyotaka Yamazaki, Tomohiro Nakamura, Naoki Agata, Ataru Igarashi, Toshiro Tango, Yoshiya Tanaka
INTRODUCTION: The Adalimumab Non-interventional Trial for Up-verified Effects and Utility (ANOUVEAU) was a large-scale, multicenter, prospective, observational, single-cohort study that evaluated the effects of adalimumab (ADA) on rheumatoid arthritis (RA)-related work productivity and activity impairment (RA-related WPAI) and disease activity in routine rheumatology care in Japan. METHODS: Patients with RA were categorized as paid workers (PWs, ≥35 h/week), part-time workers (PTWs, <35 h/week), or homemakers (HMs, unemployed) and were administered the WPAI for RA (WPAI/RA) questionnaire...
January 31, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28126477/highly-efficient-and-selective-removal-of-trace-lead-from-aqueous-solutions-by-hollow-mesoporous-silica-loaded-with-molecularly-imprinted-polymers
#7
Zulei Zhang, Xingdi Zhang, Dechao Niu, Yongsheng Li, Jianlin Shi
A novel type of adsorbent for the selective recognition and adsorption of trace Pb(2+) from aqueous solutions has been successfully constructed simply by grafting molecularly imprinted polymers (MIPs) onto hollow mesoporous silica (HMS). Attractively, the HMS loaded with MIPs (H-MIPs) exhibits a fast adsorption kinetics, marked adsorption capacity of 40.52mg/g and extremely high selectivity toward Pb(2+) over Cu(2+), Zn(2+), Co(2+), Mn(2+) and Ni(2+), and the selectivity coefficients have been determined to be as high as 50...
January 4, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28110170/tailoring-polymeric-hybrid-micelles-with-lymph-node-targeting-ability-to-improve-the-potency-of-cancer-vaccines
#8
Qin Zeng, Hanmei Li, Hao Jiang, Jiao Yu, Ying Wang, Huan Ke, Tao Gong, Zhirong Zhang, Xun Sun
It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs) and inadequate retention within LNs undoubtedly restrains their strength on activating T cell immunity. Here, we address this issue by tailoring the physicochemical properties of polymeric hybrid micelles (HMs), which are self-assembled from two amphiphilic diblock copolymers, poly-(ethylene glycol) phosphorethanolamine (PEG-PE) and polyethylenimine-stearic acid conjugate (PSA) via hydrophobic and electrostatic interactions...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28104559/distribution-of-heavy-metals-and-metalloids-in-bulk-and-particle-size-fractions-of-soils-from-coal-mine-brownfield-and-implications-on-human-health
#9
Hongxia Li, Hongbing Ji, Chunjing Shi, Yang Gao, Yan Zhang, Xiangyu Xu, Huaijian Ding, Lei Tang, Yuxin Xing
Heavy metals (HMs) and metalloids migrate into their surroundings, thus increasing environmental risks and threatening human health. Current studies on coal-mine brownfields, however, have not thoroughly investigated soil-associated HMs and metalloids produced by coal mining. Therefore, this study explored the spatial and particle fraction distribution and human health implications of HMs and metalloids. The soil-associated HMs and metalloids are Arsenic (As), Cadmium (Cd), Chromium (Cr), Copper (Cu), Mercury (Hg), Manganese (Mn), Nickel (Ni), Lead (Pb), Scandium (Sc), Titanium (Ti) and Zinc (Zn)...
April 2017: Chemosphere
https://www.readbyqxmd.com/read/28104557/a-comparative-study-on-capability-of-different-tree-species-in-accumulating-heavy-metals-from-soil-and-ambient-air
#10
Ahmad Alahabadi, Mohammad Hassan Ehrampoush, Mohammad Miri, Hamideh Ebrahimi Aval, Samira Yousefzadeh, Hamid Reza Ghaffari, Ehsan Ahmadi, Parvaneh Talebi, Zeynab Abaszadeh Fathabadi, Fatemeh Babai, Ali Nikoonahad, Kiomars Sharafi, Ahmad Hosseini-Bandegharaei
Heavy metals (HMs) in the urban environment can be bio-accumulated by plant tissues. The aim of this study was to compare fourteen different tree species in terms of their capability to accumulate four airborne and soilborne HMs including; zinc (Zn), copper (Cu), lead (Pb), and cadmium (Cd). Samplings were performed during spring, summer, and fall seasons. To compare bioaccumulation ability, bio-concentration factor (BCF), comprehensive bio-concentration index (CBCI), and metal accumulation index (MAI) were applied...
April 2017: Chemosphere
https://www.readbyqxmd.com/read/28098662/management-of-a-patient-with-antiphospholipid-syndrome-undergoing-aortic-valve-replacement-using-the-hepcon-hemostasis-management-system-plus-and-rotational-thromboelastometry-a-case-report
#11
Yuriko Samejima, Mitsuharu Kodaka, Junko Ichikawa, Tetsu Mori, Kazuyoshi Ando, Keiko Nishiyama, Makiko Komori
A 72-year-old woman with antiphospholipid syndrome underwent aortic valve replacement. Her preoperative activated partial thromboplastin time was 61.7 seconds and activated clotting time was 219 seconds. During cardiopulmonary bypass, the Hepcon Hemostasis Management System (HMS) Plus determined the heparin dose needed to maintain whole-body heparin at 3 U/mL. After cardiopulmonary bypass, 100 mg of protamine was administered based on heparin-protamine neutralization, and the activated clotting time decreased...
January 16, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28075564/spatiotemporal-trends-of-heavy-metals-in-indo-pacific-humpback-dolphins-sousa-chinensis-from-the-western-pearl-river-estuary-china
#12
Duan Gui, Ri-Qing Yu, Leszek Karczmarski, Yulong Ding, Haifei Zhang, Yong Sun, Mei Zhang, Yuping Wu
We assessed the spatiotemporal trends of the concentrations of 11 heavy metals (HMs) in the liver and kidney of Indo-Pacific humpback dolphins (Sousa chinensis) from western Pearl River Estuary (PRE) during 2004-2015. The hepatic levels of Cr, As, and Cu in these dolphins were among the highest reported for cetaceans globally, and the levels of Zn, Cu, and Hg were sufficiently high to cause toxicological effects in some of the animals. Between same age-sex groups, dolphins from Lingdingyang were significantly more contaminated with Hg, Se, and V than those from the West-four region, while the opposite was true for Cd...
January 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28052344/understanding-the-molecular-mechanisms-of-the-interplay-between-herbal-medicines-and-gut-microbiota
#13
REVIEW
Jun Xu, Hu-Biao Chen, Song-Lin Li
Herbal medicines (HMs) are much appreciated for their significant contribution to human survival and reproduction by remedial and prophylactic management of diseases. Defining the scientific basis of HMs will substantiate their value and promote their modernization. Ever-increasing evidence suggests that gut microbiota plays a crucial role in HM therapy by complicated interplay with HM components. This interplay includes such activities as: gut microbiota biotransforming HM chemicals into metabolites that harbor different bioavailability and bioactivity/toxicity from their precursors; HM chemicals improving the composition of gut microbiota, consequently ameliorating its dysfunction as well as associated pathological conditions; and gut microbiota mediating the interactions (synergistic and antagonistic) between the multiple chemicals in HMs...
January 4, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28038419/comparison-of-arbuscular-mycorrhizal-fungal-effects-on-the-heavy-metal-uptake-of-a-host-and-a-non-host-plant-species-in-contact-with-extraradical-mycelial-network
#14
Mejda Mnasri, Martina Janoušková, Jana Rydlová, Chedly Abdelly, Tahar Ghnaya
The effects of inoculation with an arbuscular mycorrhizal (AM) fungus on Cd and Ni tolerance and uptake in Medicago sativa, an AM host, and Sesuvium portulacastrum, a non-host plant, were investigated in a greenhouse experiment. The plants were cultivated in sterilized sand in a two-compartmented system, which prevented root competition but enabled colonization of the whole substrate by AM fungal extraradical mycelium. M. sativa was either left non-inoculated or inoculated with the AM fungus Rhizophagus irregularis, and both plants were either cultivated without heavy metal (HM) addition or supplied with cadmium (Cd) or nickel (Ni), each in two doses...
December 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/28030418/the-impact-of-a-junior-faculty-fellowship-award-on-academic-advancement-and-retention
#15
Maureen T Connelly, Amy M Sullivan, Manuel Chinchilla, Margaret L Dale, S Jean Emans, Carol Cooperman Nadelson, Malkah Tolpin Notman, Nancy J Tarbell, Corwin M Zigler, Eleanor G Shore
PURPOSE: Academic faculty experience barriers to career development and promotion. In 1996, Harvard Medical School (HMS) initiated an intramural junior faculty fellowship to address these obstacles. The authors sought to understand whether receiving a fellowship was associated with more rapid academic promotion and retention. METHOD: Junior faculty fellowship recipients and all other instructor and assistant professors at HMS between 1996 and 2011 were identified...
December 27, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28000710/the-application-of-homemade-neosinocalamus-affinis-ac-in-electrokinetic-removal-technology-on-heavy-metal-removal-from-the-mswi-fly-ash
#16
Kexiang Liu, Tao Huang, Xiao Huang, Lin Yu, Faheem Muhammad, Binquan Jiao, Dongwei Li
This present paper was focused on the manufacture of activated carbon (AC) and its application in the electrokinetic remediation (EKR) technology on removal of the heavy metals (HMs) from the municipal solid waste incineration fly ash. AC was produced from Neosinocalamus affinis (NF) by chemical activation with H3PO4 in N2 atmosphere, the effects of activation temperatures, soaking time and impregnation ratios on the adsorption capacity of AC on HMs were examined through equilibrium adsorption experiments. The AC produced under the condition of 450 °C of activation temperature, 10 h of soaking time and 1...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000102/translational-modeling-and-simulation-in-supporting-early-phase-clinical-development-of-new-drug-a-learn-research-confirm-process
#17
Dongyang Liu, Yi Zhang, Ji Jiang, John Choi, Xuening Li, Dalong Zhu, Dawei Xiao, Yanhua Ding, Hongwei Fan, Li Chen, Pei Hu
BACKGROUND AND OBJECTIVE: Pharmacokinetic/pharmacodynamic modeling and simulation can aid clinical drug development by dynamically integrating key system- and drug-specific information into predictive profiles. In this study, we propose a methodology to predict pharmacokinetic/pharmacodynamic profiles of sinogliatin (HMS-5552, RO-5305552), a novel glucokinase activator to treat diabetes mellitus, for first-in-patient (FIP) studies. METHODS AND RESULTS: Initially, pharmacokinetic/pharmacodynamic profiles of sinogliatin and another glucokinase activator (US2) previously acquired from healthy subjects were fitted using Model A incorporating an indirect response mechanism...
December 20, 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/27984184/electrophysiological-characterization-of-the-m-current-in-rat-hypoglossal-motoneurons
#18
Filippo Ghezzi, Silvia Corsini, Andrea Nistri
The M-current (IM) is a voltage-dependent, persistent K(+) current so termed because it is strongly inhibited by the cholinergic agonist muscarine. The IM main function is to limit neuronal excitability by contrasting action potential firing. Although motoneurons are sensitive to acetylcholine, the role of IM in modulating their excitability is still controversial. The aim of the present report was to examine the presence of IM in hypoglossal motoneurons (HMs) and its role in the modulation of firing properties using an in vitro model of rat brainstem slice...
October 27, 2016: Neuroscience
https://www.readbyqxmd.com/read/27960375/hierarchical-nife-layered-double-hydroxide-hollow-microspheres-with-highly-efficient-behavior-toward-oxygen-evolution-reaction
#19
Cong Zhang, Mingfei Shao, Lei Zhou, Zhenhua Li, Kaiming Xiao, Min Wei
The exploitation of highly efficiency and low-cost electrocatalysts toward oxygen evolution reaction (OER) is a meaningful route in renewable energy technologies including solar fuel and water splitting. Herein, NiFe-layered double hydroxide (NiFe-LDH) hollow microsphere (HMS) was designed and synthesized via a one-step in situ growth method by using SiO2 as a sacrificial template. Benefiting from the unique architecture, NiFe-LDH HMS shows highly efficient OER electrocatalytic activity with a preferable current density (71...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27940373/clinical-features-of-brain-metastases-in-small-cell-lung-cancer-an-implication-for-hippocampal-sparing-whole-brain-radiation-therapy
#20
Wen-Long Guo, Zhen-Yu He, Yue Chen, Dong Zhou, Kai Tang, Peng Wang, Sheng-Quan Zhan, San-Gang Wu
PURPOSE: To assess the clinical features and distribution of brain metastases (BMs) of small cell lung cancer (SCLC) in the hippocampal and perihippocampal region, with the purpose of exploring the viability of hippocampal-sparing whole-brain radiation therapy (HS-WBRT) on reducing neurocognitive deficits. METHODS: This was a retrospective analysis of the clinical characteristics and patterns of BMs in patients with SCLC. Associations between the clinical characteristics and hippocampal metastases (HMs)/perihippocampal metastases (PHMs) were evaluated in univariate and multivariate regression analyses...
December 7, 2016: Translational Oncology
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