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https://www.readbyqxmd.com/read/28075564/spatio-temporal-trends-of-heavy-metals-in-indo-pacific-humpback-dolphins-sousa-chinensis-from-the-western-pearl-river-estuary-china
#1
Duan Gui, Riqing Yu, Leszek Karczmarski, Yulong Ding, Haifei Zhang, Yong Sun, Mei Zhang, Yuping Wu
We assessed the spatio-temporal trends of the concentrations of 11 heavy metals (HMs) in the liver and kidney of Indo-Pacific humpback dolphins (Sousa chinensis) from western Pearl River Estuary (PRE) during 2004-2015. The hepatic levels of Cr, As and Cu in these dolphins were among the highest reported for cetaceans globally, and the levels of Zn, Cu and Hg were sufficiently high to cause toxicological effects in some of the animals. Between same age-sex groups, dolphins from Lingdingyang were significantly more contaminated with Hg, Se and V than those from the West-four region, while the opposite was true for Cd...
January 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28052344/understanding-the-molecular-mechanisms-of-the-interplay-between-herbal-medicines-and-gut-microbiota
#2
REVIEW
Jun Xu, Hu-Biao Chen, Song-Lin Li
Herbal medicines (HMs) are much appreciated for their significant contribution to human survival and reproduction by remedial and prophylactic management of diseases. Defining the scientific basis of HMs will substantiate their value and promote their modernization. Ever-increasing evidence suggests that gut microbiota plays a crucial role in HM therapy by complicated interplay with HM components. This interplay includes such activities as: gut microbiota biotransforming HM chemicals into metabolites that harbor different bioavailability and bioactivity/toxicity from their precursors; HM chemicals improving the composition of gut microbiota, consequently ameliorating its dysfunction as well as associated pathological conditions; and gut microbiota mediating the interactions (synergistic and antagonistic) between the multiple chemicals in HMs...
January 4, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28038419/comparison-of-arbuscular-mycorrhizal-fungal-effects-on-the-heavy-metal-uptake-of-a-host-and-a-non-host-plant-species-in-contact-with-extraradical-mycelial-network
#3
Mejda Mnasri, Martina Janoušková, Jana Rydlová, Chedly Abdelly, Tahar Ghnaya
The effects of inoculation with an arbuscular mycorrhizal (AM) fungus on Cd and Ni tolerance and uptake in Medicago sativa, an AM host, and Sesuvium portulacastrum, a non-host plant, were investigated in a greenhouse experiment. The plants were cultivated in sterilized sand in a two-compartmented system, which prevented root competition but enabled colonization of the whole substrate by AM fungal extraradical mycelium. M. sativa was either left non-inoculated or inoculated with the AM fungus Rhizophagus irregularis, and both plants were either cultivated without heavy metal (HM) addition or supplied with cadmium (Cd) or nickel (Ni), each in two doses...
December 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/28030418/the-impact-of-a-junior-faculty-fellowship-award-on-academic-advancement-and-retention
#4
Maureen T Connelly, Amy M Sullivan, Manuel Chinchilla, Margaret L Dale, S Jean Emans, Carol Cooperman Nadelson, Malkah Tolpin Notman, Nancy J Tarbell, Corwin M Zigler, Eleanor G Shore
PURPOSE: Academic faculty experience barriers to career development and promotion. In 1996, Harvard Medical School (HMS) initiated an intramural junior faculty fellowship to address these obstacles. The authors sought to understand whether receiving a fellowship was associated with more rapid academic promotion and retention. METHOD: Junior faculty fellowship recipients and all other instructor and assistant professors at HMS between 1996 and 2011 were identified...
December 27, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28000710/the-application-of-homemade-neosinocalamus-affinis-ac-in-electrokinetic-removal-technology-on-heavy-metal-removal-from-the-mswi-fly-ash
#5
Kexiang Liu, Tao Huang, Xiao Huang, Lin Yu, Faheem Muhammad, Binquan Jiao, Dongwei Li
This present paper was focused on the manufacture of activated carbon (AC) and its application in the electrokinetic remediation (EKR) technology on removal of the heavy metals (HMs) from the municipal solid waste incineration fly ash. AC was produced from Neosinocalamus affinis (NF) by chemical activation with H3PO4 in N2 atmosphere, the effects of activation temperatures, soaking time and impregnation ratios on the adsorption capacity of AC on HMs were examined through equilibrium adsorption experiments. The AC produced under the condition of 450 °C of activation temperature, 10 h of soaking time and 1...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000102/translational-modeling-and-simulation-in-supporting-early-phase-clinical-development-of-new-drug-a-learn-research-confirm-process
#6
Dongyang Liu, Yi Zhang, Ji Jiang, John Choi, Xuening Li, Dalong Zhu, Dawei Xiao, Yanhua Ding, Hongwei Fan, Li Chen, Pei Hu
BACKGROUND AND OBJECTIVE: Pharmacokinetic/pharmacodynamic modeling and simulation can aid clinical drug development by dynamically integrating key system- and drug-specific information into predictive profiles. In this study, we propose a methodology to predict pharmacokinetic/pharmacodynamic profiles of sinogliatin (HMS-5552, RO-5305552), a novel glucokinase activator to treat diabetes mellitus, for first-in-patient (FIP) studies. METHODS AND RESULTS: Initially, pharmacokinetic/pharmacodynamic profiles of sinogliatin and another glucokinase activator (US2) previously acquired from healthy subjects were fitted using Model A incorporating an indirect response mechanism...
December 20, 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/27984184/electrophysiological-characterization-of-the-m-current-in-rat-hypoglossal-motoneurons
#7
Filippo Ghezzi, Silvia Corsini, Andrea Nistri
The M-current (IM) is a voltage-dependent, persistent K(+) current so termed because it is strongly inhibited by the cholinergic agonist muscarine. The IM main function is to limit neuronal excitability by contrasting action potential firing. Although motoneurons are sensitive to acetylcholine, the role of IM in modulating their excitability is still controversial. The aim of the present report was to examine the presence of IM in hypoglossal motoneurons (HMs) and its role in the modulation of firing properties using an in vitro model of rat brainstem slice...
October 27, 2016: Neuroscience
https://www.readbyqxmd.com/read/27960375/hierarchical-nife-layered-double-hydroxide-hollow-microspheres-with-highly-efficient-behavior-toward-oxygen-evolution-reaction
#8
Cong Zhang, Mingfei Shao, Lei Zhou, Zhenhua Li, Kaiming Xiao, Min Wei
The exploitation of highly efficiency and low-cost electrocatalysts toward oxygen evolution reaction (OER) is a meaningful route in renewable energy technologies including solar fuel and water splitting. Herein, NiFe-layered double hydroxide (NiFe-LDH) hollow microsphere (HMS) was designed and synthesized via a one-step in situ growth method by using SiO2 as a sacrificial template. Benefiting from the unique architecture, NiFe-LDH HMS shows highly efficient OER electrocatalytic activity with a preferable current density (71...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27940373/clinical-features-of-brain-metastases-in-small-cell-lung-cancer-an-implication-for-hippocampal-sparing-whole-brain-radiation-therapy
#9
Wen-Long Guo, Zhen-Yu He, Yue Chen, Dong Zhou, Kai Tang, Peng Wang, Sheng-Quan Zhan, San-Gang Wu
PURPOSE: To assess the clinical features and distribution of brain metastases (BMs) of small cell lung cancer (SCLC) in the hippocampal and perihippocampal region, with the purpose of exploring the viability of hippocampal-sparing whole-brain radiation therapy (HS-WBRT) on reducing neurocognitive deficits. METHODS: This was a retrospective analysis of the clinical characteristics and patterns of BMs in patients with SCLC. Associations between the clinical characteristics and hippocampal metastases (HMs)/perihippocampal metastases (PHMs) were evaluated in univariate and multivariate regression analyses...
December 7, 2016: Translational Oncology
https://www.readbyqxmd.com/read/27930707/native-phytoremediation-potential-of-urtica-dioica-for-removal-of-pcbs-and-heavy-metals-can-be-improved-by-genetic-manipulations-using-constitutive-camv-35s-promoter
#10
Jitka Viktorova, Zuzana Jandova, Michaela Madlenakova, Petra Prouzova, Vilem Bartunek, Blanka Vrchotova, Petra Lovecka, Lucie Musilova, Tomas Macek
Although stinging nettle (Urtica dioica) has been shown to reduce HM (heavy metal) content in soil, its wider phytoremediation potential has been neglected. Urtica dioica was cultivated in soils contaminated with HMs or polychlorinated biphenyls (PCBs). After four months, up to 33% of the less chlorinated biphenyls and 8% of HMs (Zn, Pb, Cd) had been removed. Bacteria were isolated from the plant tissue, with the endophytic bacteria Bacillus shackletonii and Streptomyces badius shown to have the most significant effect...
2016: PloS One
https://www.readbyqxmd.com/read/27924039/flyrnai-org-the-database-of-the-drosophila-rnai-screening-center-and-transgenic-rnai-project-2017-update
#11
Yanhui Hu, Aram Comjean, Charles Roesel, Arunachalam Vinayagam, Ian Flockhart, Jonathan Zirin, Lizabeth Perkins, Norbert Perrimon, Stephanie E Mohr
The FlyRNAi database of the Drosophila RNAi Screening Center (DRSC) and Transgenic RNAi Project (TRiP) at Harvard Medical School and associated DRSC/TRiP Functional Genomics Resources website (http://fgr.hms.harvard.edu) serve as a reagent production tracking system, screen data repository, and portal to the community. Through this portal, we make available protocols, online tools, and other resources useful to researchers at all stages of high-throughput functional genomics screening, from assay design and reagent identification to data analysis and interpretation...
January 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923318/herbal-medicines-challenges-in-the-modern-world-part-5-status-and-current-directions-of-complementary-and-alternative-herbal-medicine-worldwide
#12
Elena Yu Enioutina, Emma R Salis, Kathleen M Job, Michael I Gubarev, Lubov V Krepkova, Catherine M T Sherwin
Herbal medicine (HM) use is growing worldwide. Single herb preparations, ethnic and modern HM formulations are widely used as adjunct therapies or to improve consumer wellbeing. Areas covered: This final part in the publication series summarizes common tendencies in HM use as adjunct or alternative medicine, education of healthcare professionals and consumers, current and proposed guidelines regulating of production. We discuss potential HM-HM and HM-drug interactions that could lead to severe adverse events in situations where HMs are taken without proper medical professional oversight...
December 15, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27922982/mir-21-is-overexpressed-in-hydatidiform-mole-tissues-and-promotes-proliferation-migration-and-invasion-in-choriocarcinoma-cells
#13
Ya-Xin Wang, Jiu-Ru Zhao, Yue-Ying Xu, Wei-Bin Wu, Hui-Juan Zhang
OBJECTIVE: The aims of this study were to make clear whether miR-21 was dysregulated in hydatidiform mole (HM) tissues and choriocarcinoma (CCA) cells, to elucidate whether aberrant miR-21 expression would affect the function of CCA cells, and to find out whether there was a relationship between miR-21 and AKT, PDCD4, and PTEN in CCA cells. METHODS: Fresh and formalin-fixed, paraffin-embedded trophoblastic tissues (normal first trimester placentas and HMs) were retrieved from the biobank in the International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University...
December 3, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27920298/malate-synthase-and-%C3%AE-methylmalyl-coa-lyase-reactions-in-the-methylaspartate-cycle-in-haloarcula-hispanica
#14
Farshad Borjian, Jing Han, Jing Hou, Hua Xiang, Jan Zarzycki, Ivan A Berg
: Haloarchaea are extremely halophilic heterotrophic microorganisms belonging to the class Halobacteria (Euryarchaeota). Almost half of the haloarchaea possesses the genes coding for enzymes of the methylaspartate cycle, a recently discovered anaplerotic acetate assimilation pathway. In this cycle, the enzymes of the tricarboxylic acid cycle together with the dedicated enzymes of the methylaspartate cycle convert two acetyl-CoA molecules to malate. The methylaspartate cycle involves two reactions catalyzed by homologous enzymes belonging to the CitE-like enzyme superfamily, the malyl-CoA lyase/thioesterase (haloarchaeal malate synthase, hMS, Hah_2476 in Haloarcula hispanica) and the β-methylmalyl-CoA lyase (hMCL, Hah_1341)...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27918474/hazard-management-dealt-by-safety-professionals-in-colleges-the-impact-of-individual-factors
#15
Tsung-Chih Wu, Chi-Hsiang Chen, Nai-Wen Yi, Pei-Chen Lu, Shan-Chi Yu, Chien-Peng Wang
Identifying, evaluating, and controlling workplace hazards are important functions of safety professionals (SPs). The purpose of this study was to investigate the content and frequency of hazard management dealt by safety professionals in colleges. The authors also explored the effects of organizational factors/individual factors on SPs' perception of frequency of hazard management. The researchers conducted survey research to achieve the objective of this study. The researchers mailed questionnaires to 200 SPs in colleges after simple random sampling, then received a total of 144 valid responses (response rate = 72%)...
December 3, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27914349/effects-of-clay-minerals-hydroxides-and-timing-of-dissolved-organic-matter-addition-on-the-competitive-sorption-of-copper-nickel-and-zinc-a-column-experiment
#16
Yasser Refaey, Boris Jansen, John R Parsons, Pim de Voogt, Simone Bagnis, Adriaan Markus, Abdel-Hamid El-Shater, Abdel-Aziz El-Haddad, Karsten Kalbitz
Infiltration of heavy metal (HM) polluted wastewater can seriously compromise soil and groundwater quality. Interactions between mineral soil components (e.g. clay minerals) and dissolved organic matter (DOM) play a crucial role in determining HM mobility in soils. In this study, the influence of the timing of addition of DOM, i.e. concurrent with or prior to HMs, on HM mobility was explored in a set of continuous flow column experiments using well defined natural soil samples amended with goethite, birnessite and/or smectite...
February 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27899973/expression-patterns-of-maspin-and-mutant-p53-are-associated-with-the-development-of-gestational-trophoblastic-neoplasia
#17
Pengming Sun, Qibin Wu, Guanyu Ruan, Xiu Zheng, Yiyi Song, Jianfan Zhun, Lixiang Wu, Walter H Gotlieb
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal proliferation of trophoblastic cells. GTDs encompass hydatidiform moles (HMs) and gestational trophoblastic neoplasia (GTN). GTNs are a group of malignant diseases that require chemotherapy, or more aggressive treatment. There is a requirement for more tumor markers to predict the development of GTN from HMs. The current study evaluated the expression of maspin and tumor protein p53 (p53) in GTD, and their role in predicting the development of GTN...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899623/combining-transcription-factor-binding-affinities-with-open-chromatin-data-for-accurate-gene-expression-prediction
#18
Florian Schmidt, Nina Gasparoni, Gilles Gasparoni, Kathrin Gianmoena, Cristina Cadenas, Julia K Polansky, Peter Ebert, Karl Nordström, Matthias Barann, Anupam Sinha, Sebastian Fröhler, Jieyi Xiong, Azim Dehghani Amirabad, Fatemeh Behjati Ardakani, Barbara Hutter, Gideon Zipprich, Bärbel Felder, Jürgen Eils, Benedikt Brors, Wei Chen, Jan G Hengstler, Alf Hamann, Thomas Lengauer, Philip Rosenstiel, Jörn Walter, Marcel H Schulz
The binding and contribution of transcription factors (TF) to cell specific gene expression is often deduced from open-chromatin measurements to avoid costly TF ChIP-seq assays. Thus, it is important to develop computational methods for accurate TF binding prediction in open-chromatin regions (OCRs). Here, we report a novel segmentation-based method, TEPIC, to predict TF binding by combining sets of OCRs with position weight matrices. TEPIC can be applied to various open-chromatin data, e.g. DNaseI-seq and NOMe-seq...
November 29, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27884841/herbal-medicines-for-the-treatment-of-otitis-media-with-effusion-a-systematic-review-of-randomised-controlled-trials
#19
Mi Ju Son, Songie Choi, Young-Eun Kim, Yun Hee Kim
OBJECTIVES: This systematic review aimed to assess the clinical evidence supporting the use of herbal medicines (HMs) for the treatment of otitis media with effusion (OME). DESIGN: Systematic review and meta-analysis. DATA SOURCES: MEDLINE, EMBASE, Cochrane Library, AMED, CINAHL and three trial registries were searched up to January 2015. We also searched five Korean medical databases (KoreaMed, RISS, OASIS, DBPIA and KISS) and three Chinese databases (CNKI, Wanfang and VIP)...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27882081/effects-of-different-sutures-on-fibrosis-and-wound-healing-in-a-rabbit-model-of-corneal-wounds
#20
Ying Li, Hui J Chen, Hua Zhang, Jian G Wu, Yun T Hu, Zhi Z Ma
The aim of the study was to investigate wound healing and scar formation in rabbit corneal lamellar wounds repaired with simple interrupted sutures (SIS) or horizontal mattress sutures (HMS). Two parallel 'I'-shaped lamellar cornea wounds were created in one eye of 40 white New Zealand rabbits, while 5 uninjured rabbits were sacrificed to serve as normal controls. One side of the wounds, in the test rabbits, was closed with SIS, while the other side was treated with HMS. Ten days later, the stitches were removed under anesthesia...
November 2016: Experimental and Therapeutic Medicine
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