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https://www.readbyqxmd.com/read/29909183/predictors-and-outcome-surgery-for-posterior-cortex-epilepsies
#1
Jianguo Shi, Zaifen Gao, Jun Gao, Gang Li, Yehong Chen
OBJECTIVE: The aim of this study is to identify the prognostic role of MRI and EEG in posterior cortex epilepsies (PCES) and to characterize their clinical features. PATIENT AND METHODS: We retrospectively studied 54 consecutive patients (18 females, 36 males) from April 2011 to November 2015, who had undergone PCES surgery. Electro-clinical, pathological and surgical data were evaluated. Of the patients, 18 (33.3%) patients underwent a cortical resection (corticectomy), 10 (18...
June 9, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29905159/atypical-postictal-transient-subcortical-t2-hypointensity-in-a-newly-diagnosed-diabetic-patient-with-seizures
#2
Matteo Paoletti, Ana Bacila, Anna Pichiecchio, Lisa Maria Farina, Elisa Rognone, Riccardo Cremascoli, Simona Fanucchi, Raffaele Manni, Stefano Bastianello
Common postictal MRI findings include transient cortical T2 hyperintensity, restricted diffusion, and gyral and/or adjacent leptomeningeal contrast enhancement. In certain uncommon pathological conditions, other signal abnormalities can be present, suggesting a different underlying pathogenic mechanism. We report the case of a 66-year-old man, recently diagnosed with diabetes mellitus type 2, presenting with new-onset visual and auditory hallucinations, "absence" seizures, and repeated peaks of hyperglycaemia without hyperketonaemia or increased serum osmolarity...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29905157/idiopathic-generalised-epilepsies-of-adult-onset-a-reappraisal-and-literature-review
#3
José Pimentel, Sara Varanda, Pedro Guimarães, Fernando Lopes da Silva
Idiopathic generalised epilepsies are characterised by widespread, symmetric, bilateral spike-and-wave discharges on EEG. Onset typically occurs in children and adolescents, but may also start in adulthood. These forms of adult onset constitute the focus of this review. A critical analysis of the medical literature was conducted through a narrative review search of PubMed and Medline databases. Cases of idiopathic generalised epilepsies with adult onset, in general, are not considered to be independent nosological entities...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29899784/hemimegalencephaly-seizure-outcome-in-an-infant-after-hemispherectomy
#4
Prem Chand, Pooja Manglani, Qalab Abbas
Isolated hemimegalencephaly (iHME) is a rare form of congenital malformation of cortical development characterized by enlargement of all or part of one cerebral hemisphere. It typically presents with intractable seizures, developmental delay, contralateral hemiparesis, and hemianopia. We report a case of an 18-month-old girl who presented first with focal seizures at tenth day of life, with no other physical or behavioral abnormality. Initial EEG showed excessive sharp EEG transients more over the right hemisphere; repeated EEG showed spikes, polyspikes, sharps, and slow wave discharges predominately over the right hemisphere...
January 2018: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29897043/early-onset-epileptic-encephalopathy-with-myoclonic-seizures-related-to-9q33-3-q34-11-deletion-involving-stxbp1-and-sptan1-genes
#5
Akilandeswari Aravindhan, Kinal Shah, Jayoung Pak, Aravindhan Veerapandiyan
We describe a 10-month-old boy with early-onset epileptic encephalopathy who was found to have a hemizygous deletion in 9q33.3-q34.11 involving STXBP1 and SPTAN1 genes. He presented at the age of 2.5 months with frequent upper extremity myoclonus, hypotonia, and facial dysmorphisms. Interictal EEG showed multifocal polyspike and wave during wakefulness and sleep. Ictal EEG revealed low-amplitude generalized sharp slow activity, followed by diffuse attenuation. Metabolic testing was unrevealing. Brain MRI showed thinning of the corpus callosum with an absence of rostrum...
June 12, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29897002/early-amplitude-integrated-electroencephalogram-as-a-predictor-of-brain-injury-in-newborns-with-very-low-birth-weight-a-cohort-study
#6
Luiza V S Magalhães, Maria Isabel B Winckler, José Augusto Bragatti, Renato S Procianoy, Rita C Silveira
PURPOSE: To evaluate the relationship between abnormal early amplitude integrated electroencephalography (EEG) and severe lesions in imaging tests performed during the neonatal period in very low birth weight infants. METHODS: An amplitude-integrated EEG was performed in 70 patients with a mean birth weight of 1226 g during the first 48 hours of life. Severe lesions on magnetic resonance imaging (MRI) or ultrasonography (US) during the neonatal period were considered as adverse conditions...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29881339/new-protocol-for-quantitative-analysis-of-brain-cortex-electroencephalographic-activity-in-patients-with-psychiatric-disorders
#7
Grzegorz M Wojcik, Jolanta Masiak, Andrzej Kawiak, Piotr Schneider, Lukasz Kwasniewicz, Nikodem Polak, Anna Gajos-Balinska
The interview is still the main and most important tool in psychiatrist's work. The neuroimaging methods such as CT or MRI are widely used in other fields of medicine, for instance neurology. However, psychiatry lacks effective quantitative methods to support of diagnosis. A novel neuroinformatic approach to help clinical patients by means of electroencephalographic technology in order to build foundations for finding neurophysiological biomarkers of psychiatric disorders is proposed. A cohort of 30 right-handed patients (21 males, 9 females) with psychiatric disorders (mainly with panic and anxiety disorder, Asperger syndrome as well as with phobic anxiety disorders, schizophrenia, bipolar affective disorder, obsessive-compulsive disorder, nonorganic hypersomnia, and moderate depressive episode) were examined using the dense array EEG amplifier in the P300 experiment...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29877883/18f-fdg-pet-brain-in-a-patient-with-fatal-familial-insomnia
#8
Wei Ying Tham, Yee-Liang Thian, Pavanni Ratnagopal, Wanying Xie
A 57-year-old woman presented with a 3-month history of cognitive impairment, daytime somnolence, and violent sleep behavior. Her first- and second-degree relatives had similar symptoms prior to their premature deaths. Her MRI scan of the brain showed no significant abnormality. Electroencephalogram showed loss of slow-wave activity. Functional brain imaging performed with F-FDG PET was fused with her MRI scans. This demonstrated profound hypometabolism in bilateral thalami and the posterior cingulate cortex, which is pathognomonic for familial fatal insomnia...
June 5, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29865192/magnetic-resonance-imaging-and-interictal-electroencephalography-findings-in-newly-diagnosed-epileptic-children
#9
Mehmet Alp Dirik, Burcin Sanlidag
INTRODUCTION: Epilepsy is one of the most frequently diagnosed chronic neurological disorders in children. Diagnosis is often based on seizure history and electroencephalography (EEG) assessment. Magnetic resonance imaging (MRI) is recommended for etiologic workup and intervention requirements. We aimed to detect by MRI if focal structural abnormalities are present in the brain in relation to interictal epileptiform discharges (IED). MATERIAL AND METHODS: The study was designed retrospectively...
June 1, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29864492/big-data-sharing-and-analysis-to-advance-research-in-post-traumatic-epilepsy
#10
REVIEW
Dominique Duncan, Paul Vespa, Asla Pitkanen, Adebayo Braimah, Nina Lapinlampi, Arthur W Toga
We describe the infrastructure and functionality for a centralized preclinical and clinical data repository and analytic platform to support importing heterogeneous multi-modal data, automatically and manually linking data across modalities and sites, and searching content. We have developed and applied innovative image and electrophysiology processing methods to identify candidate biomarkers from MRI, EEG, and multi-modal data. Based on heterogeneous biomarkers, we present novel analytic tools designed to study epileptogenesis in animal model and human with the goal of tracking the probability of developing epilepsy over time...
June 1, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29858947/double-match-of-18-f-fluorodeoxyglucose-pet-and-iomazenil-spect-improves-outcomes-of-focus-resection-surgery
#11
Ayataka Fujimoto, Tohru Okanishi, Sotaro Kanai, Keishiro Sato, Shinji Itamura, Shimpei Baba, Mitsuyo Nishimura, Takayuki Masui, Hideo Enoki
BACKGROUND: When the results of electroencephalography (EEG), magnetic resonance imaging (MRI), and seizure semiology are discordant or no structural lesion is evident on MRI, single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are important examinations for lateralization or localization of epileptic regions. We hypothesized that the concordance between interictal 2-[18 F]fluoro-2-deoxy-D-glucose (18 FDG)-PET and iomazenil (IMZ)-SPECT could suggest the epileptogenic lobe in patients with non-lesional findings on MRI...
June 1, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29848532/unusual-case-of-cerebral-demyelination-and-bilateral-optic-neuritis-in-an-infant-with-suppurative-bcg-lymphadenitis
#12
Poorani Anandakrishnan, Teik Beng Khoo
Cerebral demyelination and optic neuritis are often seen in children with acute disseminated encephalomyelitis following various infections and immunisations. An eight month old girl presented with a left axillary lymph node swelling and an erythematous lace-like rash over her cheeks and trunk. She then developed acute encephalopathy, bilateral nystagmus, right hemiparesis and left facial nerve palsy. Her electroencephalogram showed an encephalopathic process and visual evoked response study were grossly abnormal...
May 30, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29845763/upper-airway-dynamic-imaging-during-tidal-breathing-in-awake-and-asleep-subjects-with-obstructive-sleep-apnea-and-healthy-controls
#13
Chantal Darquenne, Ann R Elliott, Bastien Sibille, Erik T Smales, Pamela N DeYoung, Rebecca J Theilmann, Atul Malhotra
We used magnetic resonance imaging (MRI) to quantify change in upper airway dimension during tidal breathing in subjects with obstructive sleep apnea (OSA, N = 7) and BMI-matched healthy controls (N = 7) during both wakefulness and natural sleep. Dynamic MR images of the upper airway were obtained on a 1.5 T MR scanner in contiguous 7.5 mm-thick axial slices from the hard palate to the epiglottis along with synchronous MRI-compatible electroencephalogram and nasal/oral flow measurements. The physiologic data were retrospectively scored to identify sleep state, and synchronized with dynamic MR images...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29804159/is-deep-brain-involvement-in-intracranial-primary-central-nervous-system-lymphoma-of-importance-for-penetration-of-chemotherapeutic-agents
#14
Torstein R Meling, Anna Latysheva, Michele Da Broi, Guro Jahr, Harald Holte, Klaus Beiske, Kyrre Eeg Emblem
PURPOSE: The purposes of this study are to study the impact of deep brain involvement on overall survival (OS) and progression-free survival (PFS) in intracranial primary CNS lymphoma (PCNSL), and to explore possible mechanisms for this impact using advanced MRI techniques. METHODS: Seventy-nine patients with histologically verified PCNSL were identified from a prospective clinical database of patients treated at Oslo University Hospital between 2003 and 2014. Patients were treated per standard chemotherapeutic regimens (N = 57) or no chemotherapy (N = 22)...
May 27, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29801190/multiple-causes-of-pediatric-early-onset-chorea-clinical-and-genetic-approach
#15
Lubov Blumkin, Tally Lerman-Sagie, Ana Westenberger, Hilla Ben-Pazi, Ayelet Zerem, Keren Yosovich, Dorit Lev
OBJECTIVE:  This article elucidates a clinical and genetic approach to pediatric early-onset chorea in patients with normal neuroimaging. METHODS:  We retrospectively studied patients with onset hyperkinetic movement disorders. Only children with onset of chorea in the first 3 years of life were included, those with an abnormal magnetic resonance imaging (MRI) or electroencephalogram (EEG) were excluded.We studied the movement disorder phenotype by clinical examination and by interpretation of videos and compared our data to the literature...
May 25, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29800881/hypersampling-of-pseudo-periodic-signals-by-analytic-phase-projection
#16
Henning U Voss
A method to upsample insufficiently sampled experimental time series of pseudo-periodic signals is proposed. The result is an estimate of the pseudo-periodic cycle underlying the signal. This "hypersampling" requires a sufficiently sampled reference signal that defines the pseudo-periodic dynamics. The time series and reference signal are combined by projecting the time series values to the analytic phase of the reference signal. The resulting estimate of the pseudo-periodic cycle has a considerably higher effective sampling rate than the time series...
May 16, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29800799/cognitive-functions-electroencephalographic-and-diffusion-tensor-imaging-changes-in-children-with-active-idiopathic-epilepsy
#17
Imane A Yassine, Waleed M Eldeeb, Khaled A Gad, Yossri A Ashour, Inas A Yassine, Ahmed O Hosny
INTRODUCTION: Neurocognitive impairment represents one of the most common comorbidities occurring in children with idiopathic epilepsy. Diagnosis of the idiopathic form of epilepsy requires the absence of any macrostructural abnormality in the conventional MRI. Though changes can be seen at the microstructural level imaged using advanced techniques such as the Diffusion Tensor Imaging (DTI). AIM OF THE WORK: The aim of this work is to study the correlation between the microstructural white matter DTI findings, the electroencephalographic changes and the cognitive dysfunction in children with active idiopathic epilepsy...
May 21, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29794766/multiple-intracranial-lesions-as-the-unusual-imaging-features-of-hashimoto-s-encephalopathy-a-case-report
#18
Fan-Xin Kong, Qing-Hong Lu, Zhou-Ke Guo
RATIONALE: Hashimoto's encephalopathy (HE) is associated with autoimmune thyroid disease and is complex, diverse, and easily misdiagnosed. However, if HE is diagnosed and treated in a timely manner, an optimal prognosis may be achieved. PATIENT CONCERNS: We presented a case of a 63-year-old female patient with paroxysmal dizziness, unsteady gait, emotion apathy, progressive cognitive impairment, and unusual magnetic resonance imaging (MRI) findings. DIAGNOSES: After suffering for almost 8 years, the patient was diagnosed with HE based on clinical manifestation, abnormal electroencephalogram, unusual MRI findings, sensitivity to cortisol treatment, and characteristic high antithyroid peroxidase antibody (TpoAb) titer...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29780302/unified-bayesian-estimator-of-eeg-reference-at-infinity-rrest-regularized-reference-electrode-standardization-technique
#19
Shiang Hu, Dezhong Yao, Pedro A Valdes-Sosa
The choice of reference for the electroencephalogram (EEG) is a long-lasting unsolved issue resulting in inconsistent usages and endless debates. Currently, both the average reference (AR) and the reference electrode standardization technique (REST) are two primary, apparently irreconcilable contenders. We propose a theoretical framework to resolve this reference issue by formulating both (a) estimation of potentials at infinity, and (b) determination of the reference, as a unified Bayesian linear inverse problem, which can be solved by maximum a posterior estimation...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29751364/ictal-and-interictal-electric-source-imaging-in-presurgical-evaluation-a-prospective-study
#20
Praveen Sharma, Michael Scherg, Lars H Pinborg, Martin Fabricius, Guido Rubboli, Birthe Pedersen, Anne-Mette Leffers, Peter Uldall, Bo Jespersen, Jannick Brennum, Otto Mølby Henriksen, Sándor Beniczky
BACKGROUND: Accurate localization of the epileptic focus is essential for surgical treatment of patients with drug- resistant epilepsy. EEG source imaging (ESI) is increasingly used in presurgical evaluation. However, most previous studies analysed interictal discharges. Prospective studies comparing feasibility and accuracy of interictal (II) and ictal (IC) ESI are lacking. METHODS: We prospectively analysed long-term video EEG recordings (LTM) of patients admitted for presurgical evaluation...
May 11, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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