keyword
MENU ▼
Read by QxMD icon Read
search

Hypoxia and exercise

keyword
https://www.readbyqxmd.com/read/29343183/the-acute-angiogenic-signalling-response-to-low-load-resistance-exercise-with-blood-flow-restriction
#1
Richard A Ferguson, Julie E A Hunt, Mark P Lewis, Neil R W Martin, Darren J Player, Carolin Stangier, Conor W Taylor, Mark C Turner
This study investigated protein kinase activation and gene expression of angiogenic factors in response to low-load resistance exercise with or without blood flow restriction (BFR). In a repeated measures cross-over design, six males performed four sets of bilateral knee extension exercise at 20% 1RM (reps per set = 30:15:15:continued to fatigue) with BFR (110 mmHg) and without (CON). Muscle biopsies were obtained from the vastus lateralis before, 2 and 4 h post-exercise. mRNA expression was determined using real-time RT-PCR...
January 17, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29321559/the-role-of-parafacial-neurons-in-the-control-of-breathing-during-exercise
#2
Alla Korsak, Shahriar Sheikhbahaei, Asif Machhada, Alexander V Gourine, Robert T R Huckstepp
Neuronal cell groups residing within the retrotrapezoid nucleus (RTN) and C1 area of the rostral ventrolateral medulla oblongata contribute to the maintenance of resting respiratory activity and arterial blood pressure, and play an important role in the development of cardiorespiratory responses to metabolic challenges (such as hypercapnia and hypoxia). In rats, acute silencing of neurons within the parafacial region which includes the RTN and the rostral aspect of the C1 circuit (pFRTN/C1), transduced to express HM4D (Gi-coupled) receptors, was found to dramatically reduce exercise capacity (by 60%), determined by an intensity controlled treadmill running test...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313987/variable-role-of-carotid-bodies-in-cardiovascular-responses-to-exercise-hypoxia-and-hypercapnia-in-spontaneously-hypertensive-rats
#3
Wioletta Pijacka, Pedro L Katayama, Helio C Salgado, Gisele S Lincevicius, Ruy R Campos, Fiona D McBryde, Julian F R Paton
The carotid body has recently emerged as a promising therapeutic target for treating cardiovascular disease, however the potential impact of carotid bodies removal on the dynamic cardiovascular responses to acute stressors such as exercise, hypoxia and hypercapnia in hypertension is an important safety consideration that has not been studied. We first validated a novel surgical approach to selectively resect the carotid bodies bilaterally (CBR) sparing the carotid sinus baroreflex. Second, we evaluated the impact of CBR on the cardiovascular responses to exercise, hypoxia and hypercapnia in the conscious, chronically instrumented spontaneously hypertensive (SH) rats...
January 5, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29305162/neural-basis-for-reduced-executive-performance-with-hypoxic-exercise
#4
Genta Ochi, Yuhki Yamada, Kazuki Hyodo, Kazuya Suwabe, Takemune Fukuie, Kyeongho Byun, Ippeita Dan, Hideaki Soya
While accumulating evidence suggests positive effects of exercise on executive function, such effects vary with environment. In particular, exercise in a hypoxic environment (hypobaric or normobaric hypoxia), leading to decreased oxygen supply, may dampen or cancel such effects. Thus, we further explore the relation between the effects of hypoxic exercise on executive function and their underlying neural mechanisms by monitoring changes of cortical activation patterns using functional near-infrared spectroscopy (fNIRS)...
January 2, 2018: NeuroImage
https://www.readbyqxmd.com/read/29298131/a-systematic-review-of-p53-regulation-of-oxidative-stress-in-skeletal-muscle
#5
Kaitlyn Beyfuss, David A Hood
BACKGROUND: p53 is a tumor suppressor protein involved in regulating a wide array of signaling pathways. The role of p53 in the cell is determined by the type of imposed oxidative stress, its intensity and duration. The last decade of research has unravelled a dual nature in the function of p53 in mediating the oxidative stress burden. However, this is dependent on the specific properties of the applied stress and thus requires further analysis. METHODS: A systematic review was performed following an electronic search of Pubmed, Google Scholar, and ScienceDirect databases...
January 3, 2018: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/29289515/conditioned-medium-from-contracting-skeletal-muscle-cells-reverses-insulin-resistance-and-dysfunction-of-endothelial-cells
#6
Yihe Zhao, Nana Li, Zhu Li, Da Zhang, Liming Chen, Zhi Yao, Wenyan Niu
OBJECTIVE: Obese adipose tissue has been characterized with chronic inflammation associated with elevated secretion of inflammatory cytokines and declined secretion of anti-inflammatory cytokines which can impair endothelial function in an endocrine manner. Adipose tissue hypoxia plays a role in the changes of cytokines. Physical exercise / muscle contraction may help preventing cardiovascular disease through improving insulin resistance and endothelium function. However the mechanism is unclear...
December 28, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29281194/the-dewey-monitor-pulse-oximetry-can-independently-detect-hypoxia-in-a-rebreather-diver
#7
Rachel M Lance, Michael J Natoli, Sophia A S Dunworth, John J Freiberger, Richard E Moon
Rebreather diving has one of the highest fatality rates per man hour of any diving activity in the world. The leading cause of death is hypoxia, typically from equipment or procedural failures. Hypoxia causes very few symptoms prior to causing loss of consciousness. Additionally, since the electronics responsible for controlling oxygen levels in rebreathers often control their alarm systems, frequently divers do not receive any external warnings. This study investigated the use of a forehead pulse oximeter as an independent warning device in the event of rebreather failure...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29277444/entrainment-of-the-mouse-circadian-clock-effects-of-stress-exercise-and-nutrition
#8
REVIEW
Yu Tahara, Shigenobu Shibata
The circadian clock system in mammals plays a fundamental role in maintaining homeostasis. Entrainment is an important characteristic of the internal clock, by which appropriate timing is maintained according to external daily stimuli, such as light, stress, exercise, and/or food. Disorganized entrainment or a misaligned clock time, such as jet lag, increases health disturbances. The central clock in the suprachiasmatic nuclei, located in the hypothalamus, receives information about arousal stimuli, such as physical stress or exercise, and changes the clock time by modifying neural activity or the expression of circadian clock genes...
December 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29259281/effects-of-resistance-exercise-on-endothelial-progenitor-cell-mobilization-in-women
#9
Fernando Ribeiro, Ilda P Ribeiro, Ana C Gonçalves, Alberto J Alves, Elsa Melo, Raquel Fernandes, Rui Costa, Ana B Sarmento-Ribeiro, José A Duarte, Isabel M Carreira, Sarah Witkowski, José Oliveira
This study aimed to determine the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating EPCs over 24 hours in women. In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1α), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α) and erythropoietin (EPO) were measured as potential mechanisms for exercise-induced EPCs mobilization. Thirty-eight women performed a resistance exercise session at an intensity of 60% (n = 13), 70% (n = 12) or 80% (n = 13) of one repetition maximum...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29247712/effects-of-normobaric-hypoxia-on-upper-body-critical-power-and-anaerobic-working-capacity
#10
Michael B La Monica, David H Fukuda, Tristan M Starling-Smith, Ran Wang, Jay R Hoffman, Jeffrey R Stout
PURPOSE: To evaluate the effects of moderate normobaric hypoxia on the parameters of the work-time relationship in the upper body. METHODS: Twenty-one recreationally active men completed a graded exercise test in both normobaric hypoxia (H) and normoxia (N) to exhaustion on an arm ergometer to determine V̇O2peak and peak power output (PPO). Each participant completed four constant work-rate (CWR) arm-cranking tests at 90-120% PPO in both environmental conditions...
December 13, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29239993/hypoxia-during-resistance-exercise-does-not-affect-physical-performance-perceptual-responses-or-neuromuscular-recovery
#11
Brendan R Scott, Katie M Slattery, Dean V Sculley, Ben J Dascombe
This study aimed to determine whether performing resistance exercise in hypoxia affects markers of physical performance, perceptual responses, and neuromuscular function. Fourteen male subjects (age: 24.6 ± 2.7 yr; height: 179.7 ± 5.9 cm; body mass: 84.6 ± 11.6 kg) with >2 years resistance training experience performed moderate-load resistance exercise in two conditions; normoxia (FIO2 = 0.21) and hypoxia (FIO2 = 0.16). Resistance exercise comprised 3 sets of 10 repetitions of back squats and deadlifts at 60% of 1RM, with 60s inter-set rest...
December 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29220311/quantifying-the-effects-of-acute-hypoxic-exposure-on-exercise-performance-and-capacity-a-systematic-review-and-meta-regression
#12
Sanjoy K Deb, Daniel R Brown, Lewis A Gough, Christopher P McLellan, Paul A Swinton, S Andy Sparks, Lars R McNaughton
OBJECTIVE: To quantify the effects of acute hypoxic exposure on exercise capacity and performance, which includes continuous and intermittent forms of exercise. DESIGN: A systematic review was conducted with a three-level mixed effects meta-regression. The ratio of means method was used to evaluate main effects and moderators providing practical interpretations with percentage change. DATA SOURCES: A systemic search was performed using three databases (Google scholar, PubMed and SPORTDiscus)...
December 8, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/29199131/combined-therapy-involving-electroacupuncture-and-treadmill-exercise-attenuates-demyelination-in-the-corpus-callosum-by-stimulating-oligodendrogenesis-in-a-rat-model-of-neonatal-hypoxia-ischemia
#13
Malk Eun Pak, Da Hee Jung, Hong Ju Lee, Myung Jun Shin, Soo-Yeon Kim, Yong Beom Shin, Young Ju Yun, Hwa Kyoung Shin, Byung Tae Choi
We investigated whether electroacupuncture (EA) and treadmill (TM) exercise improve behaviors related to motor and memory dysfunction in a cerebral palsy-like rat model via activation of oligodendrogenesis. A neonatal hypoxia-ischemia model was created using Sprague-Dawley rats (P7), and these underwent EA stimulation and treadmill training from 3 to 5weeks after hypoxia-ischemia induction. EA treatment was delivered via electrical stimulation (2Hz, 1mA) at two acupoints, Baihui (GV20) and Zusanli (ST36). Behavioral tests showed that EA alleviated motor dysfunction caused by hypoxia-ischemia on a rotarod test, and TM exercise alleviated motor and memory dysfunction seen on cylinder and passive avoidance tests...
February 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29175484/effects-of-hypoxia-at-different-life-stages-on-locomotory-muscle-phenotype-in-deer-mice-native-to-high-altitudes
#14
Kirsten E Nikel, Naman K Shanishchara, Catherine M Ivy, Neal J Dawson, Graham R Scott
Animals native to high altitude must overcome the constraining effects of hypoxia on tissue O2 supply to support routine metabolism, thermoregulation in the cold, and exercise. Deer mice (Peromyscus maniculatus) native to high altitude have evolved an enhanced aerobic capacity in hypoxia, along with increased capillarity and oxidative capacity of locomotory muscle. Here, we examined whether exposure to chronic hypoxia during development or adulthood affects muscle phenotype. Deer mice from a highland population were bred in captivity at sea level, and exposed to normoxia or one of four treatments of hypobaric hypoxia (12kPa O2, simulating hypoxia at ~4300m): adult hypoxia (6-8weeks), post-natal hypoxia (birth to adulthood), pre-natal hypoxia (before conception to adulthood), and parental hypoxia (in which mice were conceived and raised in normoxia, but their parents were previously exposed to hypoxia)...
November 22, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29167228/contribution-of-impaired-parasympathetic-activity-to-right-ventricular-dysfunction-and-pulmonary-vascular-remodeling-in-pulmonary-arterial-hypertension
#15
Denielli da Silva Gonçalves Bos, Cathelijne E Van Der Bruggen, Kondababu Kurakula, Xiao-Qing Sun, Karina R Casali, Adenauer G Casali, Nina Rol, Robert Szulcek, Cris Dos Remedios, Christophe Guignabert, Ly Tu, Peter Dorfmuller, Marc Humbert, Paul J M Wijnker, Diederik W D Kuster, Jolanda van der Velden, Marie-José Goumans, Harm-Jan Bogaard, Anton Vonk-Noordegraaf, Frances S de Man, M Louis Handoko
Background -Beneficial effects of parasympathetic stimulation have been reported in left heart failure, however, whether it would be beneficial for pulmonary arterial hypertension (PAH) remains to be explored. Here, we investigated the relationship between parasympathetic activity and right ventricular (RV) function in PAH-patients, and the potential therapeutic effects of pyridostigmine (PYR), an oral drug stimulating the parasympathetic activity through acetylcholinesterase (AchE) inhibition, in experimental pulmonary hypertension (PH)...
November 22, 2017: Circulation
https://www.readbyqxmd.com/read/29166299/exercise-and-the-tumor-microenvironment-potential-therapeutic-implications
#16
Jennifer M Wiggins, Alexander B Opoku-Acheampong, Dryden R Baumfalk, Dietmar W Siemann, Bradley J Behnke
An imbalance in oxygen delivery to demand in solid tumors results in local areas of hypoxia leading to poor prognosis for the patient. We hypothesize that aerobic exercise increases tumor blood flow, recruits previously nonperfused tumor blood vessels, and thereby augments blood-tumor O2 transport and diminishes tumor hypoxia. When combined with conventional anticancer treatments, aerobic exercise can significantly improve the outcomes for several types of cancers.
January 2018: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29163193/changes-in-muscle-and-cerebral-deoxygenation-and-perfusion-during-repeated-sprints-in-hypoxia-to-exhaustion
#17
Sarah J Willis, Laurent Alvarez, Grégoire P Millet, Fabio Borrani
During supramaximal exercise, exacerbated at exhaustion and in hypoxia, the circulatory system is challenged to facilitate oxygen delivery to working tissues through cerebral autoregulation which influences fatigue development and muscle performance. The aim of the study was to evaluate the effects of different levels of normobaric hypoxia on the changes in peripheral and cerebral oxygenation and performance during repeated sprints to exhaustion. Eleven recreationally active participants (six men and five women; 26...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29150108/economy-class-syndrome-what-is-it-and-who-are-the-individuals-at-risk
#18
Luci Maria SantAna Dusse, Marcos Vinícius Ferreira Silva, Letícia Gonçalves Freitas, Milena Soriano Marcolino, Maria das Graças Carvalho
The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism...
October 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29130510/heterogenous-migraine-aura-symptoms-correlate-with-visual-cortex-functional-magnetic-resonance-imaging-responses
#19
Nanna Arngrim, Anders Hougaard, Khazar Ahmadi, Mark Bitsch Vestergaard, Henrik Winther Schytz, Faisal Mohammad Amin, Henrik Bo Wiberg Larsson, Jes Olesen, Michael B Hoffmann, Messoud Ashina
OBJECTIVE: Migraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. METHODS: Five migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham hypoxia, or physical exercise with concurrent photostimulation...
December 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29130497/ubc-nepal-expedition-acclimatization-to-high-altitude-increases-spinal-motoneurone-excitability-during-fatigue-in-humans
#20
Luca Ruggiero, Alexandra F Yacyshyn, Jane Nettleton, Chris J McNeil
The fatigue-induced failure of the motor cortex to drive muscles maximally increases in acute hypoxia (AH) compared to normoxia (N) but improves with acclimatization (chronic hypoxia; CH). Despite their importance to muscle output, it is unknown how locomotor motoneurones in humans are affected by hypoxia and acclimatization. Eleven participants performed 16 min of submaximal (25% maximal torque, MVC) intermittent isometric elbow flexions in N, AH (environmental chamber), and CH (7-14 days at 5050 m) (PI O2 =  140, 74, and 76 mmHg, respectively)...
November 11, 2017: Journal of Physiology
keyword
keyword
100031
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"