keyword
MENU ▼
Read by QxMD icon Read
search

Dementia supplement vascular

keyword
https://www.readbyqxmd.com/read/27687251/fully-automated-structural-mri-of-the-brain-in-clinical-dementia-workup
#1
Karin Persson, Geir Selbæk, Anne Brækhus, Mona Beyer, Maria Barca, Knut Engedal
BACKGROUND: The dementia syndrome has been regarded a clinical diagnosis but the focus on supplemental biomarkers is increasing. An automatic magnetic resonance imaging (MRI) volumetry method, NeuroQuant® (NQ), has been developed for use in clinical settings. PURPOSE: To evaluate the clinical usefulness of NQ in distinguishing Alzheimer's disease dementia (AD) from non-dementia and non-AD dementia. MATERIAL AND METHODS: NQ was performed in 275 patients diagnosed according to the criteria of ICD-10 for AD, vascular dementia and Parkinson's disease dementia (PDD); the Winblad criteria for mild cognitive impairment; the Lund-Manchester criteria for frontotemporal dementia; and the revised consensus criteria for Lewy body dementia (LBD)...
September 28, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/27598537/lesion-topography-and-microscopic-white-matter-tract-damage-contribute-to-cognitive-impairment-in-symptomatic-carotid-artery-disease
#2
Dewen Meng, Akram A Hosseini, Richard J Simpson, Quratulain Shaikh, Christopher R Tench, Robert A Dineen, Dorothee P Auer
Purpose To investigate associations between neuroimaging markers of cerebrovascular disease, including lesion topography and extent and severity of strategic and global cerebral tissue injury, and cognition in carotid artery disease (CAD). Materials and Methods All participants gave written informed consent to undergo brain magnetic resonance imaging and the Addenbrooke's Cognitive Examination-Revised. One hundred eight patients with symptomatic CAD but no dementia were included, and a score less than 82 represented cognitive impairment...
September 6, 2016: Radiology
https://www.readbyqxmd.com/read/27534711/calcium-supplementation-and-risk-of-dementia-in-women-with-cerebrovascular-disease
#3
Jürgen Kern, Silke Kern, Kaj Blennow, Henrik Zetterberg, Margda Waern, Xinxin Guo, Anne Börjesson-Hanson, Ingmar Skoog, Svante Östling
OBJECTIVE: To determine whether calcium supplementation is associated with the development of dementia in women after a 5-year follow-up. METHODS: This was a longitudinal population-based study. The sample was derived from the Prospective Population Study of Women and H70 Birth Cohort Study in Gothenburg, Sweden, and included 700 dementia-free women aged 70-92 years. At baseline in 2000-2001, and at follow-up in 2005-2006, the women underwent comprehensive neuropsychiatric and somatic examinations...
October 18, 2016: Neurology
https://www.readbyqxmd.com/read/26782037/detection-of-cerebral-amyloid-angiopathy-by-3-t-magnetic-resonance-imaging-and-amyloid-positron-emission-tomography-in-a-patient-with-subcortical-ischaemic-vascular-dementia
#4
Hirotaka Kida, Masayuki Satoh, Yuichiro Ii, Hidenao Fukuyama, Masayuki Maeda, Hidekazu Tomimoto
The patient was an 81-year-old man who had been treated for hypertension for several decades. In 2012, he developed gait disturbance and mild amnesia. One year later, his gait disturbance worsened, and he developed urinary incontinence. Conventional brain magnetic resonance imaging using T2 -weighted images and fluid-attenuated inversion recovery showed multiple lacunar infarctions. These findings fulfilled the diagnostic criteria for subcortical ischaemic vascular dementia. However, susceptibility weighted imaging showed multiple lobar microbleeds in the bilateral occipitoparietal lobes, and double inversion recovery and 3-D fluid-attenuated inversion recovery images on 3-T magnetic resonance imaging revealed cortical microinfarctions in the left parietal-temporo-occipito region...
January 18, 2016: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/26689889/homocysteine-hyperhomocysteinemia-and-vascular-contributions-to-cognitive-impairment-and-dementia-vcid
#5
Atticus H Hainsworth, Natalie E Yeo, Erica M Weekman, Donna M Wilcock
Homocysteine is produced physiologically in all cells, and is present in plasma of healthy individuals (plasma [HCy]: 3-10μM). While rare genetic mutations (CBS, MTHFR) cause severe hyperhomocysteinemia ([HCy]: 100-200μM), mild-moderate hyperhomocysteinemia ([HCy]: 10-100μM) is common in older people, and is an independent risk factor for stroke and cognitive impairment. As B-vitamin supplementation (B6, B12 and folate) has well-validated homocysteine-lowering efficacy, this may be a readily-modifiable risk factor in vascular contributions to cognitive impairment and dementia (VCID)...
May 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26635270/dietary-approaches-and-supplements-in-the-prevention-of-cognitive-decline-and-alzheimer-s-disease
#6
Ligia J Dominguez, Mario Barbagallo
Age-associated cognitive decline and dementia are conditions in which there is deterioration in memory, thinking, and behavior, with profound effects on the ability to perform everyday activities and well-being. Even if dementia mainly affects older persons, it is not a normal part of aging. Alzheimer's disease accounts for 60-75% of dementia cases. The number of persons affected will increase in the next decades in parallel with aging of the world population. Hence, unless some approach is found to reduce age-related deterioration of cognitive functions, health care costs will continue to rise exponentially...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26520792/pathobiology-of-tobacco-smoking-and-neurovascular-disorders-untied-strings-and-alternative-products
#7
REVIEW
Pooja Naik, Luca Cucullo
Tobacco smoke (TS) is the leading cause of preventable deaths worldwide. In addition to a host of well characterized diseases including chronic obstructive pulmonary disease, oral and peripheral cancers and cardiovascular complications, epidemiological evidence suggests that chronic smokers are at equal risk to develop neurological and neurovascular complications such as multiple sclerosis, Alzheimer's disease, stroke, vascular dementia and small vessel ischemic disease (SVID). Unfortunately, few direct neurotoxicology studies of tobacco smoking and its pathogenic pathways have been produced so far...
October 31, 2015: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/26456198/resveratrol-reverses-the-synaptic-plasticity-deficits-in-a-chronic-cerebral-hypoperfusion-rat-model
#8
COMPARATIVE STUDY
Huagang Li, Jing Wang, Pu Wang, Yan Rao, Liping Chen
BACKGROUND: Dementia is the most prevalent neurological disease in aged people. Chronic cerebral hypoperfusion (CCH) is one of the causes of vascular dementia (VaD) and is also an etiological factor for Alzheimer's disease (AD). However, effective therapy for those two diseases is still missing. Resveratrol is a polyphenol produced by plants that have multiple biological functions, such as increased life span and delay in the onset of diseases associated with aging. It is known supplement with resveratrol could exert neuroprotection against multiple injury factors induced neuronal death and degeneration, as well as the cognitive decline of CCH rat model...
January 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/26366714/vitamin-d-status-and-rates-of-cognitive-decline-in-a-multiethnic-cohort-of-older-adults
#9
Joshua W Miller, Danielle J Harvey, Laurel A Beckett, Ralph Green, Sarah Tomaszewski Farias, Bruce R Reed, John M Olichney, Dan M Mungas, Charles DeCarli
IMPORTANCE: Vitamin D (VitD) deficiency is associated with brain structural abnormalities, cognitive decline, and incident dementia. OBJECTIVE: To assess associations between VitD status and trajectories of change in subdomains of cognitive function in a cohort of ethnically diverse older adults. DESIGN, SETTING, AND PARTICIPANTS: Longitudinal multiethnic cohort study of 382 participants in an outpatient clinic enrolled between February 2002 and August 2010 with baseline assessment and yearly follow-up visits...
November 2015: JAMA Neurology
https://www.readbyqxmd.com/read/26358368/synergistic-effects-of-diet-and-exercise-on-hippocampal-function-in-chronically-stressed-mice
#10
C P Hutton, N Déry, E Rosa, J A Lemon, C D Rollo, D R Boreham, M Fahnestock, D deCatanzaro, J M Wojtowicz, S Becker
Severe chronic stress can have a profoundly negative impact on the brain, affecting plasticity, neurogenesis, memory and mood. On the other hand, there are factors that upregulate neurogenesis, which include dietary antioxidants and physical activity. These factors are associated with biochemical processes that are also altered in age-related cognitive decline and dementia, such as neurotrophin expression, oxidative stress and inflammation. We exposed mice to an unpredictable series of stressors or left them undisturbed (controls)...
November 12, 2015: Neuroscience
https://www.readbyqxmd.com/read/26157520/homocysteine-induced-cerebrovascular-dysfunction-a-link-to-alzheimer-s-disease-etiology
#11
P K Kamat, J C Vacek, A Kalani, N Tyagi
A high serum level of homocysteine, known as hyperhomocystenemia (HHcy) is associated with vascular dysfunction such as altered angiogenesis and increased membrane permeability. Epidemiological studies have found associations between HHcy and Alzheimer's disease (AD) progression that eventually leads to vascular dementia (VaD). VaD is the second most common cause of dementia in people older than 65, the first being AD. VaD affects the quality of life for those suffering by drastically decreasing their cognitive function...
2015: Open Neurology Journal
https://www.readbyqxmd.com/read/26094078/treatment-of-vascular-cognitive-impairment
#12
Aaron Ritter, Jagan A Pillai
Cerebrovascular disease (CVD) is an important cause of cognitive dysfunction and dementia. The term vascular cognitive impairment (VCI) is used to describe the entire spectrum of cognitive dysfunction-ranging from mild impairment to dementia-attributable to all forms of cerebrovascular disease. Accurate assessment and management of vascular risk factors are a top priority in the treatment of VCI, particularly early in the disease when prevention strategies may prove to be more effective. There are limited treatment options to improve cognition and function in VCI...
August 2015: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/26092628/brain-food-for-alzheimer-free-ageing-focus-on-herbal-medicines
#13
REVIEW
Helmut M Hügel
Healthy brain aging and the problems of dementia and Alzheimer's disease (AD) are a global concern. Beyond 60 years of age, most, if not everyone, will experience a decline in cognitive skills, memory capacity and changes in brain structure. Longevity eventually leads to an accumulation of amyloid plaques and/or tau tangles, including some vascular dementia damage. Therefore, lifestyle choices are paramount to leading either a brain-derived or a brain-deprived life. The focus of this review is to critically examine the evidence, impact, influence and mechanisms of natural products as chemopreventive agents which induce therapeutic outcomes that modulate the aggregation process of beta-amyloid (Aβ), providing measureable cognitive benefits in the aging process...
2015: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26035535/-vitamin-d-intoxication-caused-by-drugs-bought-online-sky-high-daily-dosage-for-six-months-resulted-in-severe-hypercalcemia
#14
Buster Mannheimer, Ove Törring, David Nathanson
Intoxication with vitamin D may lead to severe hypercalcemia, renal failure and occasionally to death. An increasing amount of vitamin D supplement is sold over-the-counter (OTC) or over the internet. Here we present a case were a person obtained vitamin D over the internet and administered 50 000 IE daily to his father for a period of six months, in the pursuit to stop or reverse the progression of a vascular dementia. The treatment resulted in a severe hypercalcemia and recurrent hospitalizations. In cases with an unexplained hypercalcemia, being associated with high levels of 25(OH)-vitamin D3 the possibility of intake of D-vitamin sold without a doctor's prescription should be investigated...
June 2, 2015: Läkartidningen
https://www.readbyqxmd.com/read/25961184/mediterranean-diet-and-age-related-cognitive-decline-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Cinta Valls-Pedret, Aleix Sala-Vila, Mercè Serra-Mir, Dolores Corella, Rafael de la Torre, Miguel Ángel Martínez-González, Elena H Martínez-Lapiscina, Montserrat Fitó, Ana Pérez-Heras, Jordi Salas-Salvadó, Ramon Estruch, Emilio Ros
IMPORTANCE: Oxidative stress and vascular impairment are believed to partly mediate age-related cognitive decline, a strong risk factor for development of dementia. Epidemiologic studies suggest that a Mediterranean diet, an antioxidant-rich cardioprotective dietary pattern, delays cognitive decline, but clinical trial evidence is lacking. OBJECTIVE: To investigate whether a Mediterranean diet supplemented with antioxidant-rich foods influences cognitive function compared with a control diet...
July 2015: JAMA Internal Medicine
https://www.readbyqxmd.com/read/25953366/methodological-factors-in-determining-risk-of-dementia-after-transient-ischemic-attack-and-stroke-ii-effect-of-attrition-on-follow-up
#16
Sarah T Pendlebury, Ping-Jen Chen, Sarah J V Welch, Fiona C Cuthbertson, Rose M Wharton, Ziyah Mehta, Peter M Rothwell
BACKGROUND AND PURPOSE: Cognitive outcomes in cohorts and trials are often based only on face-to-face clinic assessment. However, cognitive impairment is strongly associated with increased morbidity and mortality, leading to substantial loss to clinic follow-up. In the absence of previous population-based data, we determined the effect of such attrition on measured risk of dementia after transient ischemic attack and stroke. METHODS: Patients with transient ischemic attack or stroke prospectively recruited (2002-2007) into the Oxford Vascular (OXVASC) study had baseline clinical/cognitive assessment and follow-up to 2014...
June 2015: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/25708307/neuroprotection-in-ischemic-stroke-what-does-the-future-hold
#17
EDITORIAL
Amos D Korczyn, Michael Brainin, Alla Guekht
Neurodegenerative and vascular disease processes are commonly found concurrently in the brains of elderly patients, highlighting the difficulty in determining which processes may be responsible for cognitive impairment. Therapeutically, it may be more sensible to assume that most patients have mixed dementia. Therefore, therapies with multimodal modes of action would be expected to confer neuronal protection. Ischemic stroke is also associated with a complex pathophysiology and a high incidence of post-stroke cognitive impairment, but evidence for the efficacy of neuroprotective treatments in humans is contradictory (mainly due to a failed translation from bench to bedside)...
March 2015: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/25551132/association-of-apolipoprotein-e-genetic-variation-in-alzheimer-s-disease-in-indian-population-a-meta-analysis
#18
REVIEW
Rachna Agarwal, Chandra Bhushan Tripathi
BACKGROUND: Dementia is an age-related disorder associated with elderly population, resulting from interaction of lifestyle risk factors with genetic, vascular, and other risk factors to affect risk of disease. Alzheimer's disease (AD) is the most common form of dementia, estimated to be affecting 4.4% of the population older than 65 years of age. Apolipoprotein E (ApoE) ε4 allele is a known genetic risk factor for AD, which not only predisposes and influences the severity of pathological changes in the brain, thereby modifying the age at onset, but also promotes cognitive decline early in nondemented older people...
November 2014: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/25521180/white-matter-hypoperfusion-and-damage-in-dementia-post-mortem-assessment
#19
Seth Love, J Scott Miners
Neuroimaging has revealed a range of white matter abnormalities that are common in dementia, some that predict cognitive decline. The abnormalities may result from structural diseases of the cerebral vasculature, such as arteriolosclerosis and amyloid angiopathy, but can also be caused by nonstructural vascular abnormalities (eg, of vascular contractility or permeability), neurovascular instability or extracranial cardiac or vascular disease. Conventional histopathological assessment of the white matter has tended to conflate morphological vascular abnormalities with changes that reflect altered interstitial fluid dynamics or white matter ischemic damage, even though the latter may be of extracranial or nonstructural etiology...
January 2015: Brain Pathology
https://www.readbyqxmd.com/read/25444607/higher-homocysteine-associated-with-thinner-cortical-gray-matter-in-803-participants-from-the-alzheimer-s-disease-neuroimaging-initiative
#20
Sarah K Madsen, Priya Rajagopalan, Shantanu H Joshi, Arthur W Toga, Paul M Thompson
A significant portion of our risk for dementia in old age is associated with lifestyle factors (diet, exercise, and cardiovascular health) that are modifiable, at least in principle. One such risk factor, high-homocysteine levels in the blood, is known to increase risk for Alzheimer's disease and vascular disorders. Here, we set out to understand how homocysteine levels relate to 3D surface-based maps of cortical gray matter distribution (thickness, volume, and surface area) computed from brain magnetic resonance imaging in 803 elderly subjects from the Alzheimer's Disease Neuroimaging Initiative data set...
January 2015: Neurobiology of Aging
keyword
keyword
100030
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"