Nik Krajnc, Victor Schmidbauer, Joel Leinkauf, Lukas Haider, Gabriel Bsteh, Gregor Kasprian, Fritz Leutmezer, Barbara Kornek, Paulus Stefan Rommer, Thomas Berger, Hans Lassmann, Assunta Dal-Bianco, Simon Hametner
BACKGROUND: Paramagnetic rim lesions (PRLs) are an imaging biomarker in multiple sclerosis (MS), associated with a more severe disease. OBJECTIVES: To determine quantitative magnetic resonance imaging (MRI) metrics of PRLs, lesions with diffuse susceptibility-weighted imaging (SWI)-hypointense signal (DSHLs) and SWI-isointense lesions (SILs), their surrounding periplaque area (PPA) and the normal-appearing white matter (NAWM). METHODS: In a cross-sectional study, quantitative MRI metrics were measured in people with multiple sclerosis (pwMS) using the multi-dynamic multi-echo (MDME) sequence post-processing software "SyMRI...
September 15, 2023: Multiple Sclerosis: Clinical and Laboratory Research