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https://www.readbyqxmd.com/read/29323265/redox-dependent-bmi1-activity-drives-in-vivo-adult-cardiac-progenitor-cell-differentiation
#1
Diego Herrero, María Tomé, Susana Cañón, Francisco M Cruz, Rosa María Carmona, Encarna Fuster, Enrique Roche, Antonio Bernad
Accumulation of reactive oxygen species (ROS) is associated with several cardiovascular pathologies and with cell cycle exit by neonanatal cardiomyocytes, a key limiting factor in the regenerative capacity of the adult mammalian heart. The polycomb complex component BMI1 is linked to adult progenitors and is an important partner in DNA repair and redox regulation. We found that high BMI1 expression is associated with an adult Sca1+ cardiac progenitor sub-population with low ROS levels. In homeostasis, BMI1 repressed cell fate genes, including a cardiogenic differentiation program...
January 11, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29303551/engineering-bioinspired-antioxidant-materials-promoting-cardiomyocyte-functionality-and-maturation-for-tissue-engineering-application
#2
Parvaiz Ahmad Shiekh, Anamika Singh, Ashok Kumar
Oxidative stress plays an important role in various pathological conditions such as wound healing, inflammation, myocardial infarction and biocompatibility of the materials. Antioxidant polymers to attenuate oxidative stress is an emerging field of biomaterial research with a huge impact in the field of tissue engineering and regenerative medicine. We describe here the fabrication and evaluation of an elastomeric antioxidant polyurethane (PUAO) for tissue engineering applications. Uniaxial and cyclic tensile testing, thermal analysis, degradation, cytotoxicity and antioxidant analysis was carried out...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29288185/cohort-profile-the-emory-cardiovascular-biobank-emcab
#3
Yi-An Ko, Salim Hayek, Pratik Sandesara, Ayman Samman Tahhan, Arshed Quyyumi
PURPOSE: The Emory Cardiovascular Biobank (EmCAB) is an ongoing prospective registry of patients undergoing cardiac catheterisation, which was established to identify novel factors associated with the pathobiological process and treatment of cardiovascular disease. PARTICIPANTS: Individuals aged 18 years and older undergoing cardiac catheterisation at three Emory Healthcare sites in Atlanta are asked to participate in this prospective registry. Around 95% agree to participate...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29177006/tissue-specific-microenvironments-a-key-tool-for-tissue-engineering-and-regenerative-medicine
#4
REVIEW
Patrick C Sachs, Peter A Mollica, Robert D Bruno
The accumulated evidence points to the microenvironment as the primary mediator of cellular fate determination. Comprised of parenchymal cells, stromal cells, structural extracellular matrix proteins, and signaling molecules, the microenvironment is a complex and synergistic edifice that varies tissue to tissue. Furthermore, it has become increasingly clear that the microenvironment plays crucial roles in the establishment and progression of diseases such as cardiovascular disease, neurodegeneration, cancer, and ageing...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/29158817/extracellular-vesicles-in-cardiovascular-theranostics
#5
REVIEW
Yihua Bei, Saumya Das, Rodosthenis S Rodosthenous, Paul Holvoet, Maarten Vanhaverbeke, Marta Chagas Monteiro, Valter Vinicius Silva Monteiro, Jana Radosinska, Monika Bartekova, Felix Jansen, Qian Li, Johnson Rajasingh, Junjie Xiao
Extracellular vesicles (EVs) are small bilayer lipid membrane vesicles that can be released by most cell types and detected in most body fluids. EVs exert key functions for intercellular communication via transferring their bioactive cargos to recipient cells or activating signaling pathways in target cells. Increasing evidence has shown the important regulatory effects of EVs in cardiovascular diseases (CVDs). EVs secreted by cardiomyocytes, endothelial cells, fibroblasts, and stem cells play essential roles in pathophysiological processes such as cardiac hypertrophy, cardiomyocyte survival and apoptosis, cardiac fibrosis, and angiogenesis in relation to CVDs...
2017: Theranostics
https://www.readbyqxmd.com/read/29118467/the-light-and-shadow-of-senescence-and-inflammation-in-cardiovascular-pathology-and-regenerative-medicine
#6
REVIEW
Laura Iop, Eleonora Dal Sasso, Leonardo Schirone, Maurizio Forte, Mariangela Peruzzi, Elena Cavarretta, Silvia Palmerio, Gino Gerosa, Sebastiano Sciarretta, Giacomo Frati
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised tissue abilities to protect the heart against stress. At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29107764/current-attempts-to-implement-microrna-based-diagnostics-and-therapy-in-cardiovascular-and-metabolic-disease-a-promising-future
#7
Punniyakoti V Thanikachalam, Srinivasan Ramamurthy, Zheng W Wong, Koo B Jin, Wong J Ying, Mohd F B Abdullah, Chin Y Haur, Chia C Hou, Tan J Yi, Neo W Ting, Tan B Sen, Khan W Fang, Prashant Kesharwani
MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression at the post-translational level. miRNA-based therapeutic agents are important because of the functionality of miRNAs in regulating lipid and glucose metabolism and their role in the pathogenesis of metabolic disorders such as diabetes and obesity, where dysregulation leads to disease; they are also important in angiogenesis. miRNAs additionally serve as biomarkers in the diagnosis, prognosis and risk assessment of disease and in monitoring the response to treatment...
October 28, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29106545/extracellular-vesicles-in-diagnostics-and-therapy-of-the-ischaemic-heart-position-paper-from-the-working-group-on-cellular-biology-of-the-heart-of-the-european-society-of-cardiology
#8
Joost Petrus Gerardus Sluijter, Sean Michael Davidson, Chantal Marthe Boulanger, Edit Iren Buzás, Dominique Paschalis Victor de Kleijn, Felix Benedikt Engel, Zoltán Giricz, Derek J Hausenloy, Raj Kishore, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Cinzia Perrino, Fabrice Prunier, Susmita Sahoo, Ray Michel Schiffelers, Rainer Schulz, Linda Wilhelmina Van Laake, Kirsti Ytrehus, Péter Ferdinandy
Extracellular vesicles (EVs) - particularly exosomes and microvesicles - are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction...
November 2, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29090328/human-pluripotent-stem-cells-to-engineer-blood-vessels
#9
Xin Yi Chan, Morgan B Elliott, Bria Macklin, Sharon Gerecht
Development of pluripotent stem cells (PSCs) is a remarkable scientific advancement that allows scientists to harness the power of regenerative medicine for potential treatment of disease using unaffected cells. PSCs provide a unique opportunity to study and combat cardiovascular diseases, which continue to claim the lives of thousands each day. Here, we discuss the differentiation of PSCs into vascular cells, investigation of the functional capabilities of the derived cells, and their utilization to engineer microvascular beds or vascular grafts for clinical application...
November 1, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29076427/engineered-nanoparticles-their-properties-and-putative-applications-for-therapeutic-approaches-utilizing-stem-cells-for-the-repair-of-atherosclerotic-disease
#10
Dimitry A Chistiakov, Alexandra A Melnichenko, Alexander N Orekhov, Yuri V Bobryshev
BACKGROUND: Stem cell therapy was established as a promising approach for regenerative medicine applications such as cardiac repair. However, current stem cell-based therapeutic strategies have serious challenges such as low retention and viability of transplanted stem cells in the injured myocardium. This significantly limits efficiency of stem cell therapy. In addition, poor knowledge about the fate and survival of stem cells after transplantation represents a major reason of conflicting results from recent clinical studies...
October 27, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29057227/getting-old-through-the-blood-circulating-molecules-in-aging-and-senescence-of-cardiovascular-regenerative-cells
#11
REVIEW
Francesco Angelini, Francesca Pagano, Antonella Bordin, Vittorio Picchio, Elena De Falco, Isotta Chimenti
Global aging is a hallmark of our century. The natural multifactorial process resulting in aging involves structural and functional changes, affecting molecules, cells, and tissues. As the western population is getting older, we are witnessing an increase in the burden of cardiovascular events, some of which are known to be directly linked to cellular senescence and dysfunction. In this review, we will focus on the description of a few circulating molecules, which have been correlated to life span, aging, and cardiovascular homeostasis...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29054134/thymus-derived-mesenchymal-stem-cells-for-tissue-engineering-clinical-grade-cardiovascular-grafts
#12
Dominga Iacobazzi, Megan Swim, Ambra Albertario, Massimo Caputo, Mohamed T Ghorbel
Mesenchymal stem cells (MSCs) are attractive tools for regenerative medicine because of their multi-differentiation potential and immunomodulation capacity. In congenital heart defect surgical correction, replacement grafts lacking growth potential are commonly used. Tissue engineering promises to overcome the limitations of these grafts. In this study, we hypothesized that human thymus derived MSCs are a suitable tool to tissue engineer a living vascular graft with good integration and patency once implanted in vivo...
October 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29044850/mesenchymal-stem-cells-therapy-a-promising-cell-based-therapy-for-treatment-of-myocardial-infraction
#13
REVIEW
Ayman El Sayed Shafei, Mahmoud Ahmed Ali, Hazem G Ghanem, Ahmed I Shehata, Ahmed A Abdelgawad, Hossam R Handal, Kareem A Talaat, Ahmed E Ashaal, Amal S El-Shal
AIM: For decades, mesenchymal stem (MSCs) cells had been used for cardiovascular diseases as regenerative therapy. This review is an attempt to summarize the types of MSCs involved in MI therapy, its possible mechanisms effects especially paracrine one in MI focusing on the studies (human and animal) conducted in the last 10 years. DISCUSSION: Recently, reports showed that MSC therapy could have infarct-limiting effects after myocardial infarction (MI) in both experimental and clinical trials...
October 16, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29025705/differentiation-evaluation-and-application-of-human-induced-pluripotent-stem-cell-derived-endothelial-cells
#14
REVIEW
Yang Lin, Chang-Hyun Gil, Mervin C Yoder
The emergence of induced pluripotent stem cell (iPSC) technology paves the way to generate large numbers of patient-specific endothelial cells (ECs) that can be potentially delivered for regenerative medicine in patients with cardiovascular disease. In the last decade, numerous protocols that differentiate EC from iPSC have been developed by many groups. In this review, we will discuss several common strategies that have been optimized for human iPSC-EC differentiation and subsequent studies that have evaluated the potential of human iPSC-EC as a cell therapy or as a tool in disease modeling...
November 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28988828/epigenetics-and-cardiovascular-regenerative-medicine-in-the-elderly
#15
REVIEW
Sarah Costantino, Giovanni G Camici, Shafeeq Ahmed Mohammed, Massimo Volpe, Thomas F Lüscher, Francesco Paneni
Cardiovascular disease (CVD) is a recognized age-dependent condition whose incidence is set to increase due to the gradual aging of the population. Moreover, ischemic cardiovascular diseases (i.e. stroke, myocardial infarction, critical limb ischemia) requiring blood vessel growth are associated with a worse outcome in elderly patients. Therefore, understanding the molecular cues regulating the vascular repair process is of paramount importance to prevent undesirable cardiovascular complications in this setting...
January 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/28988692/the-survey-on-cellular-and-tissue-engineered-therapies-in-europe-and-neighboring-eurasian-countries-in-2014-and-2015
#16
Hilary Ireland, Max H P Gay, Helen Baldomero, Barbara De Angelis, Hossein Baharvand, Mark W Lowdell, Jakob Passweg, Ivan Martin
BACKGROUND AIMS: With the support of five established scientific organizations, this report, the seventh of its kind, describes activity in Europe for the years 2014 and 2015 in the area of cellular and tissue-engineered therapies, excluding hematopoietic stem cell (HSC) treatments for the reconstitution of hematopoiesis. METHODS: In 2015 [respectively 2014], 205 [276] teams from 32 countries responded to the cellular and tissue-engineered therapy survey; 178 [126] teams reported treating 3686 [2665] patients...
October 4, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28979788/zebrafish-heart-regeneration-15-years-of-discoveries
#17
REVIEW
Juan Manuel González-Rosa, Caroline E Burns, C Geoffrey Burns
Cardiovascular disease is the leading cause of death worldwide. Compared to other organs such as the liver, the adult human heart lacks the capacity to regenerate on a macroscopic scale after injury. As a result, myocardial infarctions are responsible for approximately half of all cardiovascular related deaths. In contrast, the zebrafish heart regenerates efficiently upon injury through robust myocardial proliferation. Therefore, deciphering the mechanisms that underlie the zebrafish heart's endogenous regenerative capacity represents an exciting avenue to identify novel therapeutic strategies for inducing regeneration of the human heart...
June 2017: Regeneration
https://www.readbyqxmd.com/read/28975032/propofol-2-6-diisopropylphenol-is-an-applicable-immersion-anesthetic-in-the-axolotl-with-potential-uses-in-hemodynamic-and-neurophysiological-experiments
#18
Mathias Møller Thygesen, Mikkel Mylius Rasmussen, Jesper Guldsmed Madsen, Michael Pedersen, Henrik Lauridsen
The Mexican axolotl (Ambystoma mexicanum) is an important model species in regenerative biology. Traditionally, axolotls are anesthetized using benzocaine or MS-222, both of which act to inhibit voltage gated sodium channels thereby preventing action potential propagation. In some neurophysiological experiments this is not desirable; therefore we tested propofol as an alternative anesthetic in the axolotl. We evaluated benzocaine, MS-222, and propofol's cardiovascular effects, effects on action potential propagation in the spinal cord, and gross limb regenerative effects...
June 2017: Regeneration
https://www.readbyqxmd.com/read/28974500/sex-differences-in-circulating-progenitor-cells
#19
Matthew L Topel, Salim S Hayek, Yi-An Ko, Pratik B Sandesara, Ayman Samman Tahhan, Iraj Hesaroieh, Ernestine Mahar, Greg S Martin, Edmund K Waller, Arshed A Quyyumi
BACKGROUND: Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circulating PCs in both healthy persons and patients with coronary artery disease, and to determine their association with sex hormone levels. METHODS AND RESULTS: In 642 participants (mean age 48 years, 69% women, 23% black) free from cardiovascular disease, we measured circulating PC counts as CD45med+ mononuclear cells coexpressing CD34 and its subsets expressing CD133, chemokine (C-X-C motif) receptor 4, and vascular endothelial growth factor receptor 2 epitopes using flow cytometry...
October 3, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28963863/hemocompatibility-of-hyaluronan-enhanced-linear-low-density-polyethylene-for-blood-contacting-applications
#20
Rachael Simon-Walker, John Cavicchia, David A Prawel, Lakshmi Prasad Dasi, Susan P James, Ketul C Popat
Despite their overall success, different blood-contacting medical devices such as heart valves, stents, and so forth, are still plagued with hemocompatibility issues which often result in the need for subsequent replacement and/or life-long anticoagulation therapy. Consequently, there is a significant interest in developing biomaterials that can address these issues. Polymeric-based materials have been proposed for use in many applications due to their ability to be finely tuned through manufacturing and surface modification to enhance hemocompatibility...
September 30, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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