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https://www.readbyqxmd.com/read/27871114/bone-marrow-stromal-stem-cells-in-tissue-engineering-and-regenerative-medicine
#1
A Polymeri, W V Giannobile, D Kaigler
Bone marrow stromal stem cells (BMSCs) are adult multipotent cells, which have the potential to differentiate into cell types of mesodermal origin, namely osteocytes, adipocytes, and chondrocytes. Due to their accessibility and expansion potential, BMSCs have historically held therapeutic promise in tissue engineering and regenerative medicine applications. More recently, it has been demonstrated that not only can bone marrow stromal stem cells directly participate in tissue regeneration, but they also have the capacity to migrate to distant sites of tissue injury, where they can participate in tissue repair either directly through their differentiation or indirectly through paracrine mechanisms...
November 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et M├ętabolisme
https://www.readbyqxmd.com/read/27866022/novel-approaches-toward-the-generation-of-bioscaffolds-as-a-potential-therapy-in-cardiovascular-tissue-engineering
#2
REVIEW
Fahimeh Shahabipour, Maciej Banach, Thomas P Johnston, Matteo Pirro, Amirhossein Sahebkar
Cardiovascular disease associated with myocardial infarction (MI) is among the leading causes of mortality worldwide, in part, due to the limited regenerative capacity of tissues. Although various approaches have been employed to generate bioartificial myocardial tissues, including surgical reconstruction and the use of biosynthetic or biological cell-free grafts, many challenges still remain. Natural biomaterials based on decellularization have made significant inroads into the development of favorable biomatrices for myocardial tissue regeneration...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27856257/maternal-diabetes-and-high-glucose-in-vitro-trigger-sca1-cardiac-progenitor-cell-apoptosis-through-foxo3a
#3
Penghua Yang, Wendy W Yang, Xi Chen, Sunjay Kaushal, Daoyin Dong, Wei-Bin Shen
Recent controversies surrounding the authenticity of c-kit(+) cardiac progenitor cells significantly push back the advance in regenerative therapies for cardiovascular diseases. There is an urgent need for research in characterizing alternative types of cardiac progenitor cells. Towards this goal, in the present study, we determined the effect of maternal diabetes on Sca1(+) cardiac progenitor cells. Maternal diabetes induced caspase 3-dependent apoptosis in Sca1(+) cardiac progenitor cells derived from embryonic day 17...
November 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27854552/regulation-of-sequential-release-of-growth-factors-using-bilayer-polymeric-nanoparticles-for-cardiac-tissue-engineering
#4
Mohammad Izadifar, Michael E Kelly, Xiongbiao Chen
AIM: Cardiac tissue engineering aims to develop engineered constructs for myocardial infarction repair, where a challenge is the control of growth factor (GF) sequential release. Herein, bilayer polymeric nanoparticles composed of a GF-encapsulating core surrounded by rate-regulating shell were developed for sequential GF release. MATERIALS & METHODS: Single and bilayer polymeric nanoparticles were fabricated, characterized and biologically assessed. A novel 'Geno-Neural model' was developed and validated for rate-programming of the nanoparticles...
November 17, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27837563/stem-cell-banking-and-its-impact-on-cardiac-regenerative-medicine
#5
Silvana Bardelli, Marco Moccetti
Cardiovascular diseases, including heart failure, are the most frequent cause of death annually, even higher than any other pathologies. Specifically, patients who suffer from myocardial infarction may encounter adverse remodeling processes of the heart that can ultimately lead to heart failure. Prognosis of patients affected by heart failure is very poor with 5-year mortality close to 50 %. Despite the impressive progress in the clinical treatment of heart failure in recent years, heart transplantation is still required to avoid death as the result of the inexorable decline in cardiac function...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27837559/cryopreservation-of-human-pluripotent-stem-cell-derived-cardiomyocytes-strategies-challenges-and-future-directions
#6
Marcela K Preininger, Monalisa Singh, Chunhui Xu
In recent years, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have emerged as a vital cell source for in vitro modeling of genetic cardiovascular disorders, drug screening, and in vivo cardiac regeneration research. Looking forward, the ability to efficiently cryopreserve hPSC-CMs without compromising their normal biochemical and physiologic functions will dramatically facilitate their various biomedical applications. Although working protocols for freezing, storing, and thawing hPSC-CMs have been established, the question remains as to whether they are optimal...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27834758/current-status-of-tissue-engineering-heart-valve
#7
Toshiharu Shinoka, Hideki Miyachi
The development of surgically implantable heart valve prostheses has contributed to improved outcomes in patients with cardiovascular disease. However, there are drawbacks, such as risk of infection and lack of growth potential. Tissue-engineered heart valve (TEHV) holds great promise to address these drawbacks as the ideal TEHV is easily implanted, biocompatible, non-thrombogenic, durable, degradable, and ultimately remodels into native-like tissue. In general, three main components used in creating a tissue-engineered construct are (1) a scaffold material, (2) a cell type for seeding the scaffold, and (3) a subsequent remodeling process driven by cell accumulation and proliferation, and/or biochemical and mechanical signaling...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27810905/management-of-endocrine-disease-regenerative-therapies-in-autoimmune-addison-s-disease-aad
#8
Earn Hui Gan, Simon Hs Pearce
The treatment for autoimmune Addison's disease (AAD) has remained virtually unchanged in the last 60 years. Most patients have symptoms that are relatively well controlled with exogenous steroid replacement but there may be persistent symptoms, recurrent adrenal crisis and poor quality of life, despite good compliance with optimal current treatments. Treatment with conventional exogenous steroid therapy is also associated with premature mortality, increased cardiovascular risk and complications related to excessive steroid replacement...
November 3, 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27803055/rebuilding-a-broken-heart-lessons-from-developmental-and-regenerative-biology
#9
REVIEW
Muge N Kuyumcu-Martinez, Michael C Bressan
In May 2016, the annual Weinstein Cardiovascular Development and Regeneration Conference was held in Durham, North Carolina, USA. The meeting assembled leading investigators, junior scientists and trainees from around the world to discuss developmental and regenerative biological approaches to understanding the etiology of congenital heart defects and the repair of diseased cardiac tissue. In this Meeting Review, we present several of the major themes that were discussed throughout the meeting and highlight the depth and range of research currently being performed to uncover the causes of human cardiac diseases and develop potential therapies...
November 1, 2016: Development
https://www.readbyqxmd.com/read/27799944/repair-injured-heart-by-regulating-cardiac-regenerative-signals
#10
REVIEW
Wen-Feng Cai, Guan-Sheng Liu, Lei Wang, Christian Paul, Zhi-Li Wen, Yigang Wang
Cardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis. Unfortunately, while high-quality regeneration can be performed in amphibians and zebrafish hearts, mammalian hearts do not respond in kind. Indeed, a long-term loss of proliferative capacity in mammalian adult cardiomyocytes in combination with dysregulated induction of tissue fibrosis impairs mammalian endogenous heart regenerative capacity, leading to deleterious cardiac remodeling at the end stage of heart failure...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27791997/stem-cells-and-vascular-regenerative-medicine
#11
J-F Stoltz, D Bensoussan, N De Isla, L Zhang, Z Han, J Magdalou, C Huselstein, J S Ye, N Li, V Decot, L Reppel
Most human tissues do not regenerate spontaneously, which is why "cell therapy" are promising alternative treatments. The Principe is simple: patients' or donors' cells are collected and introduced into the injured tissues or organs directly or in a porous 3D material, with or without modification of their properties. This concept of regenerative medicine is an emerging field which can be defined as "the way to improve health and quality of life by restoring, maintaining, or enhancing tissue and organ functions"...
October 27, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27771455/enhanced-axonal-regeneration-of-the-injured-sciatic-nerve-by-administration-of-buyang-huanwu-decoction
#12
In Ae Chang, Hee Don Lim, Ki Joong Kim, Hwachul Shin, Uk Namgung
ETHNOPHARMACOLOGICAL RELEVANCE: Buyang Huanwu decoction (BYHWD) has been used in the traditional Chinese medicine for the treatment of cardiovascular and neurological symptoms, and recent experimental studies have begun to provide evidence showing its protective effects on neural cells. Yet, its function for the regenerative responses of axons in the peripheral nerve after injury is not known. AIM OF THE STUDY: The primary objective of the present study was to explore that BYHWD is involved in growth-promoting activity of the peripheral nerve axons after injury...
October 19, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27742846/bioactive-lipids-and-circulating-progenitor-cells-in-patients-with-cardiovascular-disease
#13
Salim S Hayek, Yuri Klyachkin, Ahmed Asfour, Nima Ghasemzadeh, Mosaab Awad, Iraj Hesaroieh, Hina Ahmed, Brandon Gray, Jinhee Kim, Edmund K Waller, Arshed A Quyyumi, Ahmed K Abdel-Latif
: : Bone marrow-derived progenitor cells are mobilized into the peripheral blood after acute myocardial injury and in chronic ischemic heart disease. However, the mechanisms responsible for this mobilization are poorly understood. We examined the relationship between plasma levels of bioactive lipids and number of circulating progenitor cells (CPCs) in patients (N = 437) undergoing elective or emergent cardiac catheterization. Plasma levels of sphingosine-1 phosphate (S1P) and ceramide-1 phosphate (C1P) were quantified using mass spectrometry...
October 14, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27721705/cardiovascular-regenerative-technologies-update-and-future-outlook
#14
Anna Mallone, Benedikt Weber, Simon P Hoerstrup
In the effort of improving treatment for cardiovascular disease (CVD), scientists struggle with the lack of the regenerative capacities of finally differentiated cardiovascular tissues. In this context, the advancements in regenerative medicine contributed to the development of cell-based therapies as well as macro- and micro-scale tissue-engineering technologies. The current experimental approaches focus on different regenerative strategies including a broad spectrum of techniques such as paracrine-based stimulation of autologous cardiac stem cells, mesenchymal cell injections, 3D microtissue culture techniques and vascular tissue-engineering methods...
July 2016: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/27710832/bioprinting-3d-microfibrous-scaffolds-for-engineering-endothelialized-myocardium-and-heart-on-a-chip
#15
Yu Shrike Zhang, Andrea Arneri, Simone Bersini, Su-Ryon Shin, Kai Zhu, Zahra Goli-Malekabadi, Julio Aleman, Cristina Colosi, Fabio Busignani, Valeria Dell'Erba, Colin Bishop, Thomas Shupe, Danilo Demarchi, Matteo Moretti, Marco Rasponi, Mehmet Remzi Dokmeci, Anthony Atala, Ali Khademhosseini
Engineering cardiac tissues and organ models remains a great challenge due to the hierarchical structure of the native myocardium. The need of integrating blood vessels brings additional complexity, limiting the available approaches that are suitable to produce integrated cardiovascular organoids. In this work we propose a novel hybrid strategy based on 3D bioprinting, to fabricate endothelialized myocardium. Enabled by the use of our composite bioink, endothelial cells directly bioprinted within microfibrous hydrogel scaffolds gradually migrated towards the peripheries of the microfibers to form a layer of confluent endothelium...
December 2016: Biomaterials
https://www.readbyqxmd.com/read/27681821/mesenchymal-stem-cells-and-vascular-regeneration
#16
Wenduo Gu, Xuechong Hong, Claire Potter, Aijuan Qu, Qingbo Xu
In recent years mesenchymal stem cells (MSCs) have emerged as a promising therapeutic cell type in regenerative medicine. They hold great promise for treating cardiovascular diseases, such as myocardial infarction and limb ischemia. MSCs may be utilized in both cell-based therapy and vascular graft engineering to restore vascular function, thereby providing therapeutic benefits to patients. The efficacy of MSCs lies in their multipotent differentiation ability towards vascular smooth muscle cells, endothelial cells and other cell types, as well as their capacity to secrete various trophic factors, which are potent in promoting angiogenesis, inhibiting apoptosis and modulating immunoreaction...
September 28, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27668035/therapeutic-strategies-for-oxidative-stress-related-cardiovascular-diseases-removal-of-excess-reactive-oxygen-species-in-adult-stem-cells
#17
Hyunyun Kim, Jisoo Yun, Sang-Mo Kwon
Accumulating evidence indicates that acute and chronic uncontrolled overproduction of oxidative stress-related factors including reactive oxygen species (ROS) causes cardiovascular diseases (CVDs), atherosclerosis, and diabetes. Moreover ROS mediate various signaling pathways underlying vascular inflammation in ischemic tissues. With respect to stem cell-based therapy, several studies clearly indicate that modulating antioxidant production at cellular levels enhances stem/progenitor cell functionalities, including proliferation, long-term survival in ischemic tissues, and complete differentiation of transplanted cells into mature vascular cells...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27661443/phage-display-technology-in-biomaterials-engineering-progress-and-opportunities-for-applications-in-regenerative-medicine
#18
Ivone M Martins, Rui L Reis, Helena S Azevedo
The field of regenerative medicine has been gaining momentum steadily over the past few years. The emphasis in regenerative medicine is to use various in vitro and in vivo approaches that leverage the intrinsic healing mechanisms of the body to treat patients with disabling injuries and chronic diseases such as diabetes, osteoarthritis, and degenerative disorders of the cardiovascular and central nervous system. Phage display has been successfully employed to identify peptide ligands for a wide variety of targets, ranging from relatively small molecules (enzymes, cell receptors) to inorganic, organic, and biological (tissues) materials...
October 10, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27627572/the-thymus-a-forgotten-but-very-important-organ
#19
REVIEW
Zygmunt Zdrojewicz, Ewelina Pachura, Paulina Pachura
Medical science seems to be on the threshold of a revolution: It seems possible that in twenty years, doctors will be able to replace organs in the human body like parts in a car. This is thanks to the recent achievement of a team from the Medical Research Council Center for Regenerative Medicine in Edinburgh, Scotland - the group of researchers tried to regenerate the thymus gland in mice. The thymus gland is an essential organ for the development of the immune system, but very few people have any idea that it exists...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27620367/biomimetic-cardiac-tissue-model-enables-the-adaption-of-human-induced-pluripotent-stem-cell-cardiomyocytes-to-physiological-hemodynamic-loads
#20
Aaron J Rogers, Vladimir G Fast, Palaniappan Sethu
Induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) provide a human source of cardiomyocytes for use in cardiovascular research and regenerative medicine. However, attempts to use these cells in vivo have resulted in drastic cell death caused by mechanical, metabolic, and/or exogenous factors. To explore this issue, we designed a Biomimetic Cardiac Tissue Model (BCTM) where various parameters associated with heart function including heart rate, peak-systolic pressure, end-diastolic pressure and volume, end-systolic pressure and volume, and ratio of systole to diastole can all be precisely manipulated to apply hemodynamic loading to culture cells...
October 4, 2016: Analytical Chemistry
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