Chengwen Hang, Mohamed S Moawad, Zheyi Lin, Huixin Guo, Hui Xiong, Mingshuai Zhang, Renhong Lu, Junyang Liu, Dan Shi, Duanyang Xie, Yi Liu, Dandan Liang, Yi-Han Chen, Jian Yang
BACKGROUND: Cardiovascular diseases (CVDs) have the highest mortality worldwide. Human pluripotent stem cells (hPSCs) and their cardiomyocyte derivatives (hPSC-CMs) offer a valuable resource for disease modeling, pharmacological screening, and regenerative therapy. While most CVDs are linked to significant over-production of reactive oxygen species (ROS), the effects of current antioxidants targeting excessive ROS are limited. Nanotechnology is a powerful tool to develop antioxidants with improved selectivity, solubility, and bioavailability to prevent or treat various diseases related to oxidative stress...
March 26, 2024: Journal of Nanobiotechnology