Kang-Ning Wang, Kan Zhou, Nian-Nian Zhong, Lei-Ming Cao, Zi-Zhan Li, Yao Xiao, Guang-Rui Wang, Fang-Yi Huo, Jun-Jie Zhou, Bing Liu, Lin-Lin Bu
The signal transducer and activator of transcription 3 (STAT3), a member of the STAT family, resides in the nucleus to regulate genes essential for vital cellular functions, including survival, proliferation, self-renewal, angiogenesis, and immune response. However, continuous STAT3 activation in tumor cells promotes their initiation, progression, and metastasis, rendering STAT3 pathway inhibitors a promising avenue for cancer therapy. Nonetheless, these inhibitors frequently encounter challenges such as cytotoxicity and suboptimal biocompatibility in clinical trials...
April 12, 2024: Life Sciences