keyword
https://read.qxmd.com/read/38524138/autoimmune-nodopathy-with-anti-contactin-1-antibody-characterized-by-cerebellar-dysarthria-a-case-report-and-literature-review
#21
REVIEW
Jiajie Chen, Lingchun Liu, Hongyan Zhu, Jinming Han, Rong Li, Xiarong Gong, Hao Fu, Jingjing Long, Haixia Li, Qiang Meng
BACKGROUND: Autoimmune nodopathy (AN) has emerged as a novel diagnostic category that is pathologically different from classic chronic inflammatory demyelinating polyneuropathy. Clinical manifestations of AN include sensory or motor neuropathies, sensory ataxia, tremor, and cranial nerve involvement. AN with a serum-positive contactin-1 (CNTN1) antibody usually results in peripheral nerve demyelination. In this study, we reported a rare case of AN with CNTN1 antibodies characterized by the presence of CNTN1 antibodies in both serum and cerebrospinal fluid, which is associated with cerebellar dysarthria...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523325/torben-fog-a-danish-pioneer-in-a-multi-faceted-spectrum-of-multiple-sclerosis-research
#22
JOURNAL ARTICLE
Per Soelberg Sørensen, Stephan Bramow, Melinda Magyari, Lene Werdelin, Nils Koch-Henriksen, Patrick Vermersch, Finn Sellebjerg
Torben Fog was committed to multiple sclerosis (MS) research for more than four decades, starting before the defence of his thesis in 1948 and lasting until his death in 1987. His research was multi-facetted, making him one of the great pioneers in the study of essential parts of the pathology, immunology and treatment of MS. He has contributed with meticulous studies of the MS plaques, documenting the perivenous distribution of plaques in the spinal cord. He constructed a scoring system for the disability in MS and used a computer programme to calculate a total neurological deficit...
March 24, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38523205/clinical-features-of-adult-patients-with-positive-nmdar-igg-coexisting-with-mog-igg
#23
JOURNAL ARTICLE
Yuwei Dai, Yu Yuan, Fangfang Bi, Li Feng, Jing Li, Kai Hu, Si Chen, Qing Huang, Juan Li, Lili Long, Bo Xiao, Yuanyuan Xie, Yanmin Song
INTRODUCTION: This study was designed to analyze clinical and radiographic features of adult patients coexisting with NMDAR-IgG and MOG-IgG. METHODS: Eleven adult patients coexisting with NMDAR-IgG and MOG-IgG were collected from Xiangya Hospital, Central South University, between June 2017 and December 2021. Fifty-five patients with anti-NMDAR encephalitis and 49 with MOG-AD were served as controls. RESULTS: Onset age was 27 (IQR 20-34) years old...
March 25, 2024: Neurological Sciences
https://read.qxmd.com/read/38521093/deciphering-the-shift-from-benign-to-active-relapsing-remitting-multiple-sclerosis-insights-into-t-regulatory-cell-dysfunction-and-apoptosis-regulation
#24
JOURNAL ARTICLE
Anat Achiron, Rina Falb, Shay Menascu, David Magalashvili, Mathilda Mandel, Polina Sonis, Michael Gurevich
BACKGROUND: Relapsing-remitting multiple sclerosis (RRMS), a common demyelinating disease among young adults, follows a benign course in 10-15% of cases, where patients experience minimal neurological disability for a decade following disease onset. However, there is potential for these benign cases to transition into a clinically active, relapsing state. OBJECTIVE: To elucidate the biological mechanisms underlying the transition from benign to active RRMS using gene expression analysis...
March 21, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38519434/clinical-correlates-of-respiratory-disorders-in-patients-with-severe-multiple-sclerosis-a-cross-sectional-cohort
#25
JOURNAL ARTICLE
Elisabeth Maillart, Stefania Redolfi, Céline Louapre, Marion Houot, Emeline Chaugne, Pierantonio Laveneziana, Aurelian Ungureanu, Bruno Stankoff, Isabelle Arnulf, Caroline Papeix, Benedetta Bodini, Thomas Similowski, Catherine Lubetzki, Capucine Morélot-Panzini
BACKGROUND: Respiratory disorders remain incompletely described in multiple sclerosis (MS), even though they are a frequent cause of death. METHODS: The objective was to describe respiratory disorders in MS patients with Expanded Disability Status Score (EDSS) ⩾ 6.5. Diaphragm dysfunction was defined by at least two of the seven criteria: clinical signs, inspiratory recruitment of neck muscles during wakefulness, reduced upright vital capacity (VC) < 80%, upright-to-supine VC ⩾ 15% of upright VC, decrease in Maximal Inspiratory Pressure < 60%, phasic activation of inspiratory neck muscles during sleep, and opposition of thoracic and abdominal movements during sleep...
March 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38514857/myeloid-cell-replacement-is-neuroprotective-in-chronic-experimental-autoimmune-encephalomyelitis
#26
JOURNAL ARTICLE
Marius Marc-Daniel Mader, Alan Napole, Danwei Wu, Micaiah Atkins, Alexa Scavetti, Yohei Shibuya, Aulden Foltz, Oliver Hahn, Yongjin Yoo, Ron Danziger, Christina Tan, Tony Wyss-Coray, Lawrence Steinman, Marius Wernig
Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination of the central nervous system (CNS). Autologous hematopoietic cell transplantation (HCT) shows promising benefits for relapsing-remitting MS in open-label clinical studies, but the cellular mechanisms underlying its therapeutic effects remain unclear. Using single-nucleus RNA sequencing, we identify a reactive myeloid cell state in chronic experimental autoimmune encephalitis (EAE) associated with neuroprotection and immune suppression...
March 21, 2024: Nature Neuroscience
https://read.qxmd.com/read/38512652/neuroprotective-effects-of-rutin-against-cuprizone-induced-multiple-sclerosis-in-mice
#27
JOURNAL ARTICLE
Mariam A Nicola, Abdelraheim H Attaai, Mahmoud H Abdel-Raheem, Anber F Mohammed, Yasmin F Abu-Elhassan
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system that injures the myelin sheath, provoking progressive axonal degeneration and functional impairments. No efficient therapy is available at present to combat such insults, and hence, novel safe and effective alternatives for MS therapy are extremely required. Rutin (RUT) is a flavonoid that exhibits antioxidant, anti-inflammatory, and neuroprotective effects in several brain injuries. The present study evaluated the potential beneficial effects of two doses of RUT in a model of pattern-III lesion of MS, in comparison to the conventional standard drug; dimethyl fumarate (DMF)...
March 21, 2024: Inflammopharmacology
https://read.qxmd.com/read/38511878/rate-and-characteristics-of-inflammatory-neuropathies-associated-with-brentuximab-vedotin-therapy
#28
JOURNAL ARTICLE
Arthur Matthys, Benjamin Bardel, Fabien Le Bras, Alain Créange, Tarik Nordine, Romain Gounot, Saskia Ingen-Housz-Oro, Muriel Carvalho, Jean-Pascal Lefaucheur, Corinne Haioun, Violaine Planté-Bordeneuve, Thierry Gendre
BACKGROUND AND PURPOSE: Peripheral neuropathy is a frequent complication of brentuximab vedotin (BV), used in CD30+ lymphoma treatment. Classic BV-induced neuropathy (BV-CN) is a mild distal sensory axonal polyneuropathy. Severe BV-induced inflammatory neuropathies (BV-IN) have been described. BV-IN contribute to lymphoma-associated morbidity but might be immunotherapy-responsive. Our primary objective was to evaluate the rate of BV-IN. Our secondary objectives were to determine risk factors and warning signs...
March 21, 2024: European Journal of Neurology
https://read.qxmd.com/read/38511853/no-evidence-for-association-between-rs10191329-severity-locus-and-longitudinal-disease-severity-in-1813-relapse-onset-multiple-sclerosis-patients-from-the-msbase-registry
#29
JOURNAL ARTICLE
Maria Pia Campagna, Eva Kubala Havrdova, Dana Horakova, Guillermo Izquierdo, Fuencisla Matesanz, Sara Eichau, Jeannette Lechner-Scott, Bruce V Taylor, Maria-Isabel García-Sanchéz, Antonio Alcina, Anneke van der Walt, Helmut Butzkueven, Vilija G Jokubaitis
BACKGROUND: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. METHODS: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity...
March 21, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38511833/infectious-mononucleosis-and-risk-of-multiple-sclerosis-proxy-or-culprit
#30
EDITORIAL
Henrik Hjalgrim, Klaus Rostgaard
No abstract text is available yet for this article.
March 21, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38511730/risk-of-multiple-sclerosis-in-individuals-with-infectious-mononucleosis-a-national-population-based-cohort-study-using-hospital-records-in-england-2003-2023
#31
JOURNAL ARTICLE
Raphael Goldacre
BACKGROUND: Epstein-Barr virus (EBV) is thought to be a necessary causative agent in the development of multiple sclerosis (MS). Infectious mononucleosis (IM), which occurs up to 70% of adolescents and young adults with primary EBV infection, appears to be a further risk factor but few studies have been highly powered enough to explore this association by time since IM diagnosis. OBJECTIVE: The objective was to quantify the risk of MS in individuals with IM compared with the general population, with particular focus on time since IM diagnosis...
March 21, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38509661/facial-pain-in-ms-when-to-think-of-trigeminal-autonomic-cephalalgia
#32
JOURNAL ARTICLE
Sanjay Cheema, Manjit Matharu
No abstract text is available yet for this article.
March 20, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38509618/deletion-of-slc9a1-in-cx3cr1-cells-stimulated-microglial-subcluster-creb1-signaling-and-microglia-oligodendrocyte-crosstalk
#33
JOURNAL ARTICLE
Shanshan Song, Helena Oft, Shamseldin Metwally, Satya Paruchuri, John Bielanin, Victoria Fiesler, Chaim Sneiderman, Gary Kohanbash, Dandan Sun
Microglial Na/H exchanger-1 (NHE1) protein, encoded by Slc9a1, plays a role in white matter demyelination of ischemic stroke brains. To explore underlying mechanisms, we conducted single cell RNA-seq transcriptome analysis in conditional Slc9a1 knockout (cKO) and wild-type (WT) mouse white matter tissues at 3 days post-stroke. Compared to WT, Nhe1 cKO brains expanded a microglial subgroup with elevated transcription of white matter myelination genes including Spp1, Lgals3, Gpnmb, and Fabp5. This subgroup also exhibited more acidic pHi and significantly upregulated CREB signaling detected by ingenuity pathway analysis and flow cytometry...
March 20, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38507990/differential-diagnosis-between-multiple-sclerosis-and-leukodystrophies-a-scoping-review
#34
REVIEW
Luis Eduardo Ramos Chaer, Jakeline Martins de Mendonça, Maria Cristina Del Negro, Ricardo Titze-de-Almeida, Nícolas Philippe Balduino Nogueira, Priscila Mara Provetti, Pedro Renato de Paula Brandão, Diógenes Diego de Carvalho Bispo, Gabriela Billafan Ferreira, Ingrid Faber, Taina Barreto Cavalcante, Tarso Adoni, Juliana F Mazzeu, Felipe von Glehn
Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) characterized by damage to the myelin sheaths of oligodendrocytes. Currently, there is no specific biomarker to identify the disease; however, a diagnostic criterion has been established based on patient's clinical, laboratory, and imaging characteristics, which assists in identifying this condition. The primary method for diagnosing MS is the McDonald criteria, first described in 2001 and revised in the years 2005, 2012, and 2017...
March 16, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38507620/stem-cell-derived-extracellular-vesicle-therapy-for-multiple-sclerosis-a-systematic-review-and-meta-analysis-of-preclinical-studies
#35
JOURNAL ARTICLE
Mehri Barabadi, Madison C B Paton, Naveen Kumar, Rebecca Lim, Natalie L Payne
Stem cell therapy holds promise for multiple sclerosis (MS), with efficacy of different stem cell types reported across a range of preclinical MS animal models. While stem cell therapy has been approved for a small number of diseases in humans, extracellular vesicles (EVs) may provide an efficacious, cost-effective, and safer alternative to stem cell therapy. To this end, we conducted a systematic review with meta-analysis to assess the effectiveness of stem cell-derived secretome (EV and conditioned media (CM)) in animal models of MS...
March 20, 2024: Stem Cells Translational Medicine
https://read.qxmd.com/read/38506970/osmotic-demyelination-syndrome-associated-with-uremia-and-elevated-serum-osmolality
#36
EDITORIAL
Dana Klavansky, Destiny Lee Marquez, Madhusudan Vijayan, Alexandra S Reynolds
No abstract text is available yet for this article.
March 20, 2024: Neurocritical Care
https://read.qxmd.com/read/38505993/the-complement-system-in-neurodegenerative-diseases
#37
JOURNAL ARTICLE
Jacqui Nimmo, Robert A J Byrne, Nikoleta Daskoulidou, Lewis M Watkins, Sarah M Carpanini, Wioleta M Zelek, B Paul Morgan
Complement is an important component of innate immune defence against pathogens and crucial for efficient immune complex disposal. These core protective activities are dependent in large part on properly regulated complement-mediated inflammation. Dysregulated complement activation, often driven by persistence of activating triggers, is a cause of pathological inflammation in numerous diseases, including neurological diseases. Increasingly, this has become apparent not only in well-recognized neuroinflammatory diseases like multiple sclerosis but also in neurodegenerative and neuropsychiatric diseases where inflammation was previously either ignored or dismissed as a secondary event...
March 20, 2024: Clinical Science (1979-)
https://read.qxmd.com/read/38504646/new-onset-vision-impairment-in-children-magnetic-resonance-imaging-findings-by-age-groups
#38
JOURNAL ARTICLE
Esra Çıvgın, Semra Duran, Izzet Selçuk Parlak, Başak Gülleroğlu, İnci Elif Erbahçeci Timur, Özge Dedeoğlu, Ayşe Seçil Yücel Ekşioğlu
INTRODUCTION: Non-traumatic visual impairment is rare in the pediatric population, but early diagnosis and treatment of the cause is crucial to prevent long-term consequences affecting children's neurocognitive development. The authors aim to determine the most common causes of non-traumatic visual impairment in pediatric patients according to age groups by magnetic resonance imaging (MRI). METHODS: Images of patients who underwent contrast-enhanced cranial and orbital MRI for new-onset visual impairment between June 2019 and June 2022 were retrospectively reviewed...
March 20, 2024: Journal of Child Neurology
https://read.qxmd.com/read/38504399/neuromuscular-ultrasound-in-polyneuropathies
#39
REVIEW
Yasmin K Nasr-Eldin, Michael S Cartwright, Ahmed Hamed, Lamia Hamdy Ali, Ahmed M Abdel-Nasser
Neuromuscular ultrasound is a painless, radiation-free, high-resolution imaging technique for assessing the peripheral nervous system. It can accurately depict changes in the nerves and muscles of individuals with neuromuscular conditions, and it is therefore a robust diagnostic tool for the assessment of individuals with polyneuropathies. This review will outline the typical ultrasonographic changes found in a wide variety of polyneuropathies. In general, demyelinating conditions result in greater nerve enlargement than axonal conditions, and acquired conditions result in more patchy nerve enlargement compared to diffuse nerve enlargement in hereditary conditions...
March 19, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/38499905/extracellular-purine-metabolism-potential-target-in-multiple-sclerosis
#40
REVIEW
Danijela Laketa, Irena Lavrnja
The purinergic signaling system comprises a complex network of extracellular purines and purine-metabolizing ectoenzymes, nucleotide and nucleoside receptors, ATP release channels, and nucleoside transporters. Because of its immunomodulatory function, this system is critically involved in the pathogenesis of multiple sclerosis (MS) and its best-characterized animal model, experimental autoimmune encephalomyelitis (EAE). MS is a chronic neuroinflammatory demyelinating and neurodegenerative disease with autoimmune etiology and great heterogeneity, mostly affecting young adults and leading to permanent disability...
March 18, 2024: Molecular Neurobiology
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