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Trabecular bone score

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https://www.readbyqxmd.com/read/27908253/assessment-of-bone-quality-in-osteoporosis-treatment-with-bone-anabolic-agents-really-something-new
#1
Fabio Massimo Ulivieri, Renata Caudarella, Marzia Camisasca, Daniela Maria Cabrini, Ilaria Merli, Carmelo Messina, Luca Petruccio Piodi
Osteoporosis is a chronic pathologic condition, particularly of the elderly, in which a reduction of bone mineral density (BMD) weakens bone, leading to the so-called fragility fractures, most often of spine and femur. The gold standard exam for the quantitative measurement of BMD is the dual X-ray photon absorptiometry (DXA), a radiological method. However, a relevant number of fragility fractures occurs in the range of normal BMD values, meaning that also qualitative aspects of bone play a role, namely bone architecture and bone geometry...
December 1, 2016: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/27906844/effects-of-piezoelectric-surgery-on-bone-regeneration-following-distraction-osteogenesis-of-mandible
#2
Emre Tosun, Meric Bilgiç, Benay Yildirim, Hakan Hifzi Tüz, Taha Özer
The aim of this study is to compare the bone healing in the distraction gap following the osteotomy performed with piezoelectric and conventional devices for the distraction osteogenesis in the rabbit mandibles. Twelve rabbits were randomly divided into 2 groups; 6 for piezoelectric device and 6 for rotary instruments. After 3 days of latency period, distraction was started at a rate of 1 mm per day for 10 days. All the animals were sacrificed after 4 weeks of consolidation phase for histological and histomorphological evaluation...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27900532/mir-148a-the-epigenetic-regulator-of-bone-homeostasis-is-increased-in-plasma-of-osteoporotic-postmenopausal-women
#3
Ajda Bedene, Simona Mencej Bedrač, Lea Ješe, Janja Marc, Peter Vrtačnik, Janez Preželj, Tomaž Kocjan, Tilen Kranjc, Barbara Ostanek
BACKGROUND: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mineral density and microarchitectural deterioration of bone tissue, resulting in bone fragility and low-trauma fractures. Imaging techniques are routinely used to detect low bone mass; however, they are unable to identify deterioration of bone quality. Recently, microRNAs have emerged as regulators of bone remodelling and potentially also as a new class of sensitive biomarkers of bone health to aid in diagnosis and treatment monitoring of osteoporosis...
November 29, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27900426/the-lumbar-spine-age-related-degenerative-disease-influences-the-bmd-not-the-tbs-the-osteolaus-cohort
#4
I Padlina, E Gonzalez-Rodriguez, D Hans, M Metzger, D Stoll, B Aubry-Rozier, O Lamy
: We evaluated the influence of degenerative disease and fractured vertebra on lumbar spine bone mineral density (BMD) and trabecular bone score (TBS) in 1500 women aged 50-80 years. TBS was not affected by a degenerative disease. While BMD increases after 62.5 years, TBS continues to decline. TBS should play a leading role in lumbar spine evaluation. INTRODUCTION: After menopause, lumbar spine (LS) BMD and TBS values decrease. Degenerative disease (DD) increases with age and affect LS BMD...
November 30, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27894728/bone-density-in-patients-with-berardinelli-seip-congenital-lipodystrophy-is-higher-in-trabecular-sites-and-in-type-2-patients
#5
Josivan G Lima, Lucia Helena C Nobrega, Natalia N Lima, Marcel C F Dos Santos, Maria de Fatima P Baracho, Francisco Bandeira, Leonardo Capistrano, Francisco Paulo Freire Neto, Selma Maria B Jeronimo
Berardinelli-Seip congenital lipodystrophy (BSCL) is a rare autosomal recessive syndrome characterized by a difficulty storing lipid in adipocytes, low body fat, hypoleptinemia, and hyperinsulinemia. We report here laboratory, bone mineral density (BMD), and bone mineral content findings of 21 patients (24.1 ± 8.4 yr old, 14 females, 18 diabetics, 5.3% total body fat) with BSCL. The mean leptin was very low (0.91 ± 0.42 ng/mL), and the mean values of the Z-scores for all studied sites were positive, except for the 33% radius (Z-score -0...
November 25, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/27854548/the-benefit-of-menopausal-hormone-therapy-on-bone-density-and-microarchitecture-persists-after-its-withdrawal
#6
Georgios Papadakis, Didier Hans, Elena Gonzalez-Rodriguez, Peter Vollenweider, Gérard Waeber, Pedro Manuel Marques-Vidal, Olivier Lamy
CONTEXT: Menopausal hormone therapy (MHT) favorably affects bone mineral density (BMD). Whether MHT also affects bone microarchitecture, as assessed by trabecular bone score (TBS), has never been evaluated. OBJECTIVE: Our objective was to assess the effect of MHT on TBS and BMD before and after its withdrawal. DESIGN: This was a cross-sectional study. SETTING: This study included the general community. PATIENTS OR OTHER PARTICIPANTS: Data were collected from the OsteoLaus cohort (1500 women aged 50-80 years)...
November 17, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27832795/bone-histomorphometric-changes-in-children-with-rheumatic-disorders-on-chronic-glucocorticoids
#7
Jennifer Harrington, Douglas Holmyard, Earl Silverman, Etienne Sochett, Marc Grynpas
BACKGROUND: Rheumatic diseases are associated with an increased fracture risk. The tissue level characteristics of the bone involvement in children have not been well elucidated. Our objectives were to describe the bone micro-architectural characteristics in children with rheumatic diseases on chronic glucocorticoids, and to determine associations between micro-architectural findings with clinical and radiological variables. METHODS: Children on chronic glucocorticoids for an underlying rheumatic disease were referred for evaluation of bone fragility given the presence of vertebral compression fractures...
November 10, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27830383/cortical-bone-analysis-in-a-predialysis-population-a-comparison-with-a-dialysis-population
#8
Catarina Carvalho, J Magalhães, R Neto, L Pereira, P Branco, T Adragão, J M Frazão
This study was designed to characterize cortical bone by histomorphometry in a predialysis population, to correlate turnover, mineralization, and volume between cortical and trabecular bone, and to compare the findings with those in patients treated with maintenance dialysis. We evaluated cortical bone by histomorphometry in 16 patients with stage 3 or stage 4 chronic kidney disease and in 16 dialysis patients. Dual-energy X-ray absorptiometry (DXA) of the distal end of the forearm was performed in seven predialysis patients, and the findings correlated with histologic parameters...
November 9, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27797885/trabecular-bone-score-and-incident-fragility-fracture-risk-in-adults-with-reduced-kidney-function
#9
Kyla L Naylor, Jerilynn Prior, Amit X Garg, Claudie Berger, Lisa Langsetmo, Jonathan D Adachi, David Goltzman, Christopher S Kovacs, Robert G Josse, William D Leslie
BACKGROUND AND OBJECTIVES: Trabecular bone score is a gray-level textural measure obtained from dual energy x-ray absorptiometry lumbar spine images that provides information independent of areal bone mineral density. The association between trabecular bone score and incident fractures in adults with reduced kidney function and whether this association differs from that of adults with normal kidney function are unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We included 1426 participants ages ≥40 years old (mean age of 67 years) in the community-based Canadian Multicentre Osteoporosis Study...
November 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27791415/nine-year-results-of-whole-femoral-head-allograft-with-articular-cartilage-for-acetabular-impaction-grafting-in-revision-hip-replacement
#10
E Drampalos, A Fadulelmola, R Mohammed, D Shaw, S Subramanian, K D Jain, J Hodgkinson
INTRODUCTION Acetabular impaction bone grafting with a cemented polyethylene socket aims to reconstitute the bone stock in hip revision. This is an effective but resource intensive and time consuming technique. Usually, the articular cartilage is removed from the femoral head allograft. Our objective was to assess the late results of using the whole femoral head, retaining the cartilage. METHODS Forty-two acetabular revisions using impacted morselised bone graft (retaining the articular cartilage) and a cemented socket were studied retrospectively...
October 28, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27788473/not-only-stiffness-but-also-yield-strength-of-the-trabecular-structure-determined-by-non-linear-%C3%A2%C2%B5fe-is-best-predicted-by-bone-volume-fraction-and-fabric-tensor
#11
Sarah N Musy, Ghislain Maquer, Jarunan Panyasantisuk, Jasmin Wandel, Philippe K Zysset
The micro-architecture of cancellous bone is considered a major determinant of the fracture risk. Yet, if morphometry tells about alterations of the trabecular network, its elastic behaviour is best described by bone volume fraction (BV/TV) and the fabric tensor, which gives the anisotropy of the trabecular structure. This remains to be proven for yield strength, the onset of bone failure. The microstructure of 126 samples extracted from femoral heads of two female subjects was evaluated on micro-computed tomography scans via 25 structural indices...
October 14, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27769563/comparison-of-a-novel-porous-titanium-construct-regenerex%C3%A2-to-a-well-proven-porous-coated-tibial-surface-in-cementless-total-knee-arthroplasty-a-prospective-randomized-rsa-study-with-two-year-follow-up
#12
Nikolaj S Winther, Claus L Jensen, Claus M Jensen, Thomas Lind, Henrik M Schrøder, Gunnar Flivik, Michael M Petersen
BACKGROUND: Regenerex is a novel porous titanium construct with a three-dimensional porous structure and biomechanical characteristics close to that of normal trabecular bone. The aim of this study was to compare this novel construct to a well-proven porous plasma sprayed tibial (PPS) implant after total knee arthroplasty. METHODS: Sixty-one patients scheduled for an uncemented TKA were randomized to receive either a novel highly porous titanium construct Regenerex or the PPS tibial component...
October 18, 2016: Knee
https://www.readbyqxmd.com/read/27762599/dose-reduction-in-tomosynthesis-of-the-wrist
#13
Anton S Becker, Katharina Martini, Kai Higashigaito, Roman Guggenberger, Gustav Andreisek, Thomas Frauenfelder
OBJECTIVE: The purpose of this study was to quantitatively and qualitatively determine the impact of radiation dose reduction on the image noise and quality of tomosynthesis studies of the wrist. MATERIALS AND METHODS: Imaging of six cadaver wrists was performed with tomosynthesis in anteroposterior position at a tube voltage of 60 kV and tube current of 80 mA and subsequently at 60 or 50 kV with different tube currents of 80, 40, or 32 mA. Dose-area products (DAP) were obtained from the electronically logged protocol...
October 20, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27757772/skeletal-changes-after-restoration-of-the-euparathyroid-state-in-patients-with-hypoparathyroidism-and-primary-hyperparathyroidism
#14
Cristiana Cipriani, Alice Abraham, Barbara C Silva, Natalie E Cusano, Mishaela R Rubin, Donald J McMahon, Chengchen Zhang, Didier Hans, Shonni J Silverberg, John P Bilezikian
Restoration of the euparathyroid state is associated with improvement of bone dynamics both in hypoparathyroidism and primary hyperparathyroidism. To date, no study has directly compared these two groups following correction of parathyroid hormone excess or deficiency. The study was designed to investigate changes in bone mineral density and trabecular bone score with restoration of the euparathyroid state by parathyroidectomy in primary hyperparathyroidism or recombinant parathyroid hormone [rhPTH(1-84)] replacement in hypoparathyroidism...
October 18, 2016: Endocrine
https://www.readbyqxmd.com/read/27754806/the-effect-of-tsh-suppression-on-vertebral-trabecular-bone-scores-in-patients-with-differentiated-thyroid-carcinoma
#15
Jae Hoon Moon, Kyoung Min Kim, Tae Jung Oh, Sung Hee Choi, Soo Lim, Young Joo Park, Do Joon Park, Hak Chul Jang
DESIGN, SETTING, AND PARTICIPANTS: We conducted a retrospective cohort study including 273 postmenopausal women with DTC who had received TSH-suppressive therapy. Bone mineral density (BMD) and TBS at the lumbar spine were analyzed using dual-energy X-ray absorptiometry (DXA). Major Outcome Measure: The association between the parameters of TSH-suppressive therapy and bone parameters was investigated. RESULTS: Study subjects showed upper-normal free thyroxine (free T4) levels and suppressed TSH at DXA evaluation...
October 18, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27743070/african-americans-have-lower-tbs-than-whites-among-densitometry-patients-at-a-chicago-academic-center
#16
R K Jain, T J Vokes
: Trabecular bone score, an indirect measure of bone structure, may differ between ethnicities. We found that African Americans had lower trabecular bone score than do whites referred for densitometry, even when controlling for age and abdominal soft tissue thickness. PURPOSE: Trabecular bone score (TBS), an indirect measure of bone structure, has been shown to predict fractures in predominantly white populations. Analysis of NHANES data revealed lower TBS in African Americans than in whites...
October 14, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27741542/bone-quality-beyond-bone-mineral-density
#17
Thomas M Link, Ursula Heilmeier
Both bone mass and quality are responsible for bone strength. Whereas bone mass is measured with bone mineral density, quantification of bone quality is more complex and involves bone architecture, texture, and mechanical parameters. Over the last decade, significant progress has been made in developing technologies to measure bone quality. These include novel low-cost modalities such as trabecular bone score measured on dual-energy X-ray absorptiometry images and quantitative ultrasound as well as more advanced imaging modalities such as multidetector computed tomography, magnetic resonance imaging, and high-resolution peripheral quantitative computed tomography...
July 2016: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/27725999/added-clinical-use-of-trabecular-bone-score-to-bmd-for-major-osteoporotic-fracture-prediction-in-older-chinese-people-the-mr-os-and-ms-os-cohort-study-in-hong-kong
#18
Y Su, J Leung, D Hans, B Aubry-Rozier, T Kwok
: The thresholds of trabecular bone score (TBS) require validation for clinical application in older Chinese people. The lower threshold of TBS significantly improved the accuracy of prediction by bone mineral density-based osteoporosis status for major osteoporotic fracture in older Chinese men. INTRODUCTION: Trabecular bone score (TBS) is a relatively new indicator of skeletal fragility. Its clinical application warrants further investigations. Our aim was to validate and recommend practical thresholds of TBS for fracture prediction in older Chinese people...
October 11, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27722900/comparison-of-trabecular-bone-score-and-hip-structural-analysis-with-frax-%C3%A2-in-postmenopausal-women-with-type-2-diabetes-mellitus
#19
Gloria Bonaccorsi, Enrica Fila, Carmelo Messina, Elisa Maietti, Fabio Massimo Ulivieri, Renata Caudarella, Pantaleo Greco, Giuseppe Guglielmi
PURPOSE: To evaluate (a) the performance in predicting the presence of bone fractures of trabecular bone score (TBS) and hip structural analysis (HSA) in type 2 diabetic postmenopausal women compared to a control group and (b) the fracture prediction ability of TBS versus Fracture Risk Calculator (FRAX(®)) as well as whether TBS can improve the fracture prediction ability of FRAX(®) in diabetic women. METHODS: Eighty diabetic postmenopausal women were matched with 88 controls without major diseases for age and body mass index...
October 8, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27698108/definition-for-rheumatoid-arthritis-erosions-imaged-with-high-resolution-peripheral-quantitative-computed-tomography-and-interreader-reliability-for-detection-and-measurement
#20
Cheryl Barnabe, Dominique Toepfer, Hubert Marotte, Ellen-Margrethe Hauge, Andrea Scharmga, Roland Kocijan, Sebastian Kraus, Stephanie Boutroy, Georg Schett, Kresten Krarup Keller, Joost de Jong, Kathryn S Stok, Stephanie Finzel
OBJECTIVE: High-resolution peripheral quantitative computed tomography (HR-pQCT) sensitively detects erosions in rheumatoid arthritis (RA); however, nonpathological cortical bone disruptions are potentially misclassified as erosive. Our objectives were to set and test a definition for pathologic cortical bone disruptions in RA and to standardize reference landmarks for measuring erosion size. METHODS: HR-pQCT images of metacarpophalangeal joints of RA and control subjects were used in an iterative process to achieve consensus on the definition and reference landmarks...
October 2016: Journal of Rheumatology
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