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Trabecular bone score

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https://www.readbyqxmd.com/read/29424785/bone-density-microarchitecture-and-tissue-quality-after-1-year-of-treatment-with-tenofovir-disoproxil-fumarate
#1
Robert Güerri-Fernández, Elisabet Lerma-Chippirraz, Ana Fernandez Marron, Natalia García-Giralt, Judit Villar-García, Jade Soldado, Alicia González-Mena, Ana Guelar, Adolfo Díez-Pérez, Todd T Brown, Hernando Knobel
: Bone mineral density (BMD) measured by dual-energy x-ray absorptiometry (DXA) is used to assess bone health in HIV patients. DXA measures the amount of mineral, but not other key aspects of bone strength such as bone microarchitecture or bone quality. Trabecular Bone Score (TBS) and in vivo microindentation directly measure trabecular microarchitecture and bone tissue quality, respectively. The aim of this study is to measure bone strength properties using these techniques. RESULTS: Forty naïve HIV patients that were going to start antiretroviral (ART) a single pill treatment with Elvitegravir/cobicistat, Tenofovir (TDF), Emtricitavine (FTC) were included...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29416218/the-trabecular-bone-score-predicts-spine-fragility-fractures-in-postmenopausal-caucasian-women-without-osteoporosis-independently-of-bone-mineral-density
#2
Claudio Ripamonti, Lucia Lisi, Angela Buffa, Saverio Gnudi, Renata Caudarella
Introduction: The trabecular bone score (TBS) is a gray-level textural metric that can be extracted from the two-dimensional lumbar spine dual-energy X-ray absorptiometry (DXA) image. TBS is related to bone microarchitecture. Several literature data suggest that TBS predicts fracture risk as well as lumbar spine bone mineral density (LS-BMD) measurements in postmenopausal women. Objective: A retrospective case-control study assessing the ability of the TBS to predict spine fragility fractures (SFF) in postmenopausal women with or without osteoporosis (diagnosed by T-score≤-2...
February 2018: Medical Archives
https://www.readbyqxmd.com/read/29407072/poor-outcomes-of-fusion-with-trabecular-metal-implants-after-failed-total-ankle-replacement-early-results-in-11-patients
#3
S Aubret, L Merlini, M Fessy, J L Besse
INTRODUCTION: One of the reasons for revision of total ankle replacement (TAR) implants is loosening due to subchondral cysts. Reconstruction and fusion of the ankle is often the first choice for revision procedures due to the large bone defects, which are typically filled with autograft and/or allograft. Filling the defect with a trabecular metal tantalum implant is a potential alternative given the biomechanical properties of this component. HYPOTHESIS: Using tantalum as a spacer provides primary stability and contributes to fusion of the ankle joint after removal of failed TAR implants...
January 30, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29402167/differential-adaptations-of-the-musculoskeletal-system-following-spinal-cord-contusion-and-transection-in-rats
#4
Ching-Yi Lin, Charlie Androjna, Richard Rozic, Bich Tram Nguyen, Brett Parsons, Ronald J Midura, Yu-Shang Lee
Spinal cord injury (SCI) causes impaired neuronal function with associated deficits in the musculoskeletal system, which can lead to permanent disability. Here, the impact of SCI on in vivo musculoskeletal adaptation was determined by studying deficits in locomotor function and analyzing changes that occur in the muscle and bone compartments within the rat hind-limb following contusion or transection SCI. Analyses of locomotor patterns, as assessed via the Basso, Beattie, and Bresnahan (BBB) rating scale, revealed that transection animals showed significant deficits, while the contusion group had moderate deficits, as compared to naïve groups...
February 5, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29401540/eighteen-year-effect-of-androgen-therapy-on-bone-mineral-density-in-trans-gender-men
#5
Petr Dan Broulik, Václav Urbánek, Petr Libanský
The study explores the influence of long-term androgen supplementation (18 years) on bone metabolism in trans(gender) men. Thirty five trans(gender) men aged (47±4) were treated with adequate dose of testosterone. BMD was measured by DEXA at lumbar spine and neck and T score was determined. Biochemical parameters of bone turnover were measured in all patients. As compared with female and male age matched controls they showed a not significantly different T-score at spine [1.213±0.15 in trans(gender) men vs...
February 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29392355/risk-equivalent-t-score-adjustment-for-using-lumbar-spine-trabecular-bone-score-tbs-the-manitoba-bmd-registry
#6
W D Leslie, E Shevroja, H Johansson, E V McCloskey, N C Harvey, J A Kanis, D Hans
Lumbar spine trabecular bone score (TBS) can be used to modify the output from the fracture risk assessment tool, FRAX, to enhance fracture prediction. An alternative approach for using TBS in clinical practice, based upon an adjustment to the bone mineral density (BMD) T-score, may be helpful in regions where intervention guidelines and/or reimbursement are primarily based on BMD T-score. INTRODUCTION: The aim of this study is to develop an approach for using TBS in clinical practice based upon a "risk-equivalent" adjustment to the BMD T-score...
February 1, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29379010/isoliquiritigenin-blunts-osteoarthritis-by-inhibition-of-bone-resorption-and-angiogenesis-in-subchondral-bone
#7
Baochao Ji, Zhendong Zhang, Wentao Guo, Hairong Ma, Boyong Xu, Wenbo Mu, Abdusami Amat, Li Cao
Isoliquiritigenin (ISL), a natural flavonoid extracted from licorice, has been demonstrated to exert attenuation of osteoclastogenesis and anti-angiogenesis activity in a wide variety of cells. Here, we first evaluated the effects of ISL on pathogenesis of osteoarthritis in a mouse model of OA. The data showed that ISL blunted progression of OA and lowered the Osteoarthritis Research Society International (OARSI)-Modified Making Score and protected the articular cartilage. The thickness of calcified cartilage zone was significantly decreased in ISL-treated ACLT mice compared with vehicle group...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29373705/trabecular-bone-score-in-obese-and-non-obese-subjects-with-primary-hyperparathyroidism-before-and-after-parathyroidectomy
#8
Yu-Kwang Donovan Tay, Natalie E Cusano, Mishaela R Rubin, John Williams, Beatriz Omeragic, John P Bilezikian
Context: Obesity has been shown to be unfavorable to skeletal microarchitecture when assessed by trabecular bone score (TBS). The influence of adiposity on skeletal microstructure in primary hyperparathyroidism (PHPT) has not yet been evaluated. Objective: To investigate the effect of obesity on TBS and bone mineral density (BMD) in subjects with PHPT at baseline and through 2 years after parathyroidectomy. Design: Prospective observational study...
January 24, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29362430/efficacy-of-bisphosphonates-in-the-treatment-of-femoral-head-osteonecrosis-a-prisma-compliant-meta-analysis-of-animal-studies-and-clinical-trials
#9
Donghai Li, Zhouyuan Yang, Zhun Wei, Pengde Kang
This study aimed to determine whether bisphosphonates exert an effect on preventing femoral head collapse after osteonecrosis of the femoral head (ONFH) in an animal model and in clinical trials. A systematic literature search was performed for studies published up to January 2017. Twenty-three articles (16 animal studies, seven clinical trials) were included in the meta-analysis. We found that the bisphosphonate group obtained significant improvement in epiphyseal quotients (MD = 15.32; 95% CI, 9.25-21...
January 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29362154/model-for-improved-correlation-of-bmd-values-between-abdominal-routine-dual-energy-ct-data-and-dxa-scans
#10
Mischa Woisetschläger, Anna Spångeus
BACKGROUND: Osteoporosis is a common but underdiagnosed and undertreated disease causing severe morbidity and economic burden. The gold standard for detection of osteoporosis is DXA (dual energy x-ray absorptiometry), which is a dedicated examination for osteoporosis. Dual energy CT (DECT) examinations are increasingly used in daily routine for a wide variety of diagnoses. In the present study, we wanted to examine whether vBMD (volume bone mass density) could be evaluated as a side product in non-contrast as well as contrast phases as well as to evaluate a correction model taking known shortcomings for DXA into account...
February 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29354243/posterior-screw-fixation-in-previously-augmented-vertebrae-with-bone-cement-is-it-inapplicable
#11
Jae Hoo Park, Chang Il Ju, Seok Won Kim
Objective: The purpose of this study was to determine the feasibility of screw fixation in previously augmented vertebrae with bone cement. We also investigated the influence of cement distribution pattern on the surgical technique. Methods: Fourteen patients who required screw fixation at the level of the previous percutaneous vertebroplasty or balloon kyphoplasty were enrolled in this study. The indications for screw fixation in the previously augmented vertebrae with bone cement included delayed complications, such as cement dislodgement, cement leakage with neurologic deficits, and various degenerative spinal diseases, such as spondylolisthesis or foraminal stenosis...
January 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29335346/severity-of-sacroiliitis-and-erythrocyte-sedimentation-rate-are-associated-with-a-low-trabecular-bone-score-in-young-male-patients-with-ankylosing-spondylitis
#12
Kwi Young Kang, Min Kyung Chung, Ha Neul Kim, Yeon Sik Hong, Ji Hyeon Ju, Sung-Hwan Park
OBJECTIVE: To examine factors related to a low trabecular bone score (TBS) and the association between TBS and vertebral fractures in patients with ankylosing spondylitis (AS). METHODS: One hundred patients (all male, aged < 50 yrs) who fulfilled the modified New York criteria for the classification of AS were enrolled. The TBS and bone mineral density (BMD) were assessed using dual-energy X-ray absorptiometry. Clinical variables, inflammatory markers, and the presence of vertebral fractures were also assessed...
January 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29329765/usefulness-of-the-trabecular-bone-score-for-assessing-the-risk-of-osteoporotic-fracture
#13
L Redondo, E Puigoriol, J R Rodríguez, P Peris, E Kanterewicz
INTRODUCTION AND OBJECTIVES: The trabecular bone score (TBS) is an imaging technique that assesses the condition of the trabecular microarchitecture. Preliminary results suggest that TBS, along with the bone mineral density assessment, could improve the calculation of the osteoporotic fracture risk. The aim of this study was to analyse TBS values and their relationship with the clinical characteristics, bone mineral density and history of fractures of a cohort of posmenopausal women. MATERIAL AND METHODS: We analysed 2,257 posmenopausal women from the FRODOS cohort, which was created to determine the risk factors for osteoporotic fracture through a clinical survey and bone densitometry with vertebral morphometry...
January 9, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29329430/increases-in-igf-1-after-anti-tnf-%C3%AE-therapy-are-associated-with-bone-and-muscle-accrual-in-pediatric-crohn-s-disease
#14
Mark D DeBoer, Arthur M Lee, Kirabo Herbert, Jin Long, Meena Thayu, Lindsay M Griffin, Robert N Baldassano, Lee A Denson, Babette S Zemel, Michelle R Denburg, Rita Herskovitz, Mary B Leonard
Context: Low levels of IGF-1 in pediatric and adolescent Crohn's Disease (CD) likely contribute to bone and muscle deficits. Objective: Assess changes in IGF-1 levels and associations with bone and muscle accrual following initiation of anti-TNF-α therapy in pediatric and adolescent CD. Design and Participants: Participants (n=75, age 5-21 years) with CD were enrolled in a prospective cohort study; 63 completed the 12-month visit. Main Outcome Measures: IGF-1 levels at baseline and 10 weeks, and DXA and tibia peripheral quantitative-CT (pQCT) measures of bone and muscle at baseline and 12 months after initiation of anti-TNF-α therapy...
January 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29322222/urinary-pentosidine-levels-negatively-associates-with-trabecular-bone-scores-in-patients-with-type-2-diabetes-mellitus
#15
Y J Choi, S Y Ock, Y Jin, J S Lee, S H Kim, Y -S Chung
Pentosidine levels were higher in diabetic patients with vertebral fractures. Trabecular bone scores were negatively associated with pentosidine levels in diabetic patients only. Our results provide further evidence that AGEs are associated with the pathogenesis of bone fragility in patients with T2DM. INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with fracture risk. Pentosidine, an advanced glycation end product (AGE), is associated with prevalent vertebral fractures (VFs) in patients with T2DM...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29304151/the-role-of-carboxy-terminal-cross-linking-telopeptide-of-type-i-collagen-dual-x-ray-absorptiometry-bone-strain-and-romberg-test-in-a-new-osteoporotic-fracture-risk-evaluation-a-proposal-from-an-observational-study
#16
Fabio M Ulivieri, Luca P Piodi, Enzo Grossi, Luca Rinaudo, Carmelo Messina, Anna P Tassi, Marcello Filopanti, Anna Tirelli, Francesco Sardanelli
The consolidated way of diagnosing and treating osteoporosis in order to prevent fragility fractures has recently been questioned by some papers, which complained of overdiagnosis and consequent overtreatment of this pathology with underestimating other causes of the fragility fractures, like falls. A new clinical approach is proposed for identifying the subgroup of patients prone to fragility fractures. This retrospective observational study was conducted from January to June 2015 at the Nuclear Medicine-Bone Metabolic Unit of the of the Fondazione IRCCS Ca' Granda, Milan, Italy...
2018: PloS One
https://www.readbyqxmd.com/read/29300907/a-6-year-follow-up-of-fracture-incidence-and-volumetric-bone-mineral-density-development-in-girls-with-turner-syndrome
#17
Ondrej Soucek, Eckhard Schönau, Jan Lebl, Johannes Willnecker, Zdenek Hlavka, Zdenek Sumnik
Context: Patients with Turner Syndrome (TS) are at risk of osteoporotic fractures. Objective: The aims of this study were to assess the incidence of clinically significant fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD). Design: Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation. Setting: Government funded university referral center...
December 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29290026/trabecular-bone-quality-is-lower-in-adults-with-type-1-diabetes-and-is-negatively-associated-with-insulin-resistance
#18
V N Shah, R Sippl, P Joshee, L Pyle, W M Kohrt, I E Schauer, J K Snell-Bergeon
We evaluated trabecular bone score (TBS) and factors affecting TBS in adults with type 1 diabetes (T1D) compared to age-, sex-, and body mass index (BMI)-matched adults without diabetes. Adults with T1D had lower TBS compared to controls. Abdominal obesity and insulin resistance are associated with lower TBS. INTRODUCTION: We evaluated TBS, a non-invasive method to evaluate trabecular bone quality at the lumbar spine, in adults with T1D compared to age-, sex-, and BMI-matched adults without diabetes...
December 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29250157/myrtol-improves-post-traumatic-knee-osteoarthritis-by-regulation-of-reactive-oxygen-species-transforming-growth-factor-%C3%AE-1-and-apoptosis-in-a-mouse-model
#19
Liqun Duan, Wenzhi Zhang, Feng Zhang, Haiping Cai
The present study tested whether myrtol improves post-traumatic knee osteoarthritis (PTKO) by regulating the reactive oxygen species (ROS), transforming growth factor β1 (TGF-β1) and apoptosis in a mouse model. PTKO model mice were administered with 150, 300 or 450 mg/kg myrtol for 8 weeks. ELISA analysis was used to measure tumor necrosis factor-α, interleukin-6, malondialdehyde, superoxide dismutase, reactive oxygen species and TGF-β1 levels. Caspase-3 and Bax protein expressions were analyzed using western blot analysis...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29217393/acetabular-revision-using-trabecular-metal-augments-for-paprosky-type-3-defects
#20
Cathleen J O'Neill, Stephen B Creedon, Stephen A Brennan, Fiona J O'Mahony, Rosanne S Lynham, Shane Guerin, Rehan Gul, James A Harty
BACKGROUND: Trabecular Metal (TM) augments are one option when reconstructing bone loss during acetabular side revision surgery. METHODS: We studied 38 consecutive patients with Paprosky type 3 defects that were revised using a TM shell and one or more augments over a 6-year period. There were 29 Paprosky type 3A defects and 9 Paprosky type 3B defects. The mean age of the patients at the time of surgery was 68.2 years (range 48-84). The mean length of follow-up was 36 months (range 18-74)...
March 2018: Journal of Arthroplasty
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