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Trabecular bone score

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https://www.readbyqxmd.com/read/29893993/normative-standards-for-hrpqct-parameters-in-chinese-men-and-women
#1
Tracy Y Zhu, Benjamin Hk Yip, Vivian Wy Hung, Carol Wy Choy, Ka-Lo Cheng, Timothy Cy Kwok, Jack Cy Cheng, Ling Qin
Assessing bone architecture using high resolution peripheral quantitative computed tomography (HRpQCT) has the potential to improve fracture risk assessment. The Normal Reference Study aimed to establish sex-specific reference centile curves for HRpQCT parameters. This was an age-stratified cross-sectional study and 1,072 ambulatory Chinese men (n = 544) and women (n = 528) aged 20-79yrs, who were free from conditions and medications that could affect bone metabolism and had no history of fragility fracture, were recruited from local communities of Hong Kong...
June 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29886163/dynamic-adaptation-of-vertebral-endplate-and-trabecular-bone-following-annular-injury-in-a-rat-model-of-degenerative-disc-disease
#2
Tristan Maerz, Michael Newton, Abigail A Marek, Michael Planalp, Kevin Baker
BACKGROUND/CONTEXT: Degenerative disc disease (DDD) is associated with longitudinal remodeling of paravertebral tissues. While chronic vertebral changes in advanced stages of DDD are well-studied, very little data exists on acute vertebral bone remodeling at the onset and progression of DDD. PURPOSE: To longitudinally characterize bony remodeling in a rodent model of disc injury-induced DDD. STUDY DESIGN/SETTING: In vivo animal study involving a rat annulus fibrosus injury model of DDD...
June 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29880171/a-study-of-the-value-of-trabecular-bone-score-in-fracture-risk-assessment-of-postmenopausal-women
#3
Alireza Mirzaei, Seyed Adel Jahed, Marzieh Nojomi, Alireza Rajaei, Mozhdeh Zabihiyeganeh
OBJECTIVE: Trabecular Bone Score (TBS) is an index of bone microarchitecture that provides additional skeletal information to areal Bone Mineral Density (aBMD). Recently TBS data has been used to optimize the Fracture Risk Assessment Tool (FRAX) predictive value. The aim of this study was to evaluate the clinical value of TBS on FRAX algorithm. MATERIALS AND METHODS: Among total of 358 postmenopausal Iranian women (mean age 61.3 ± 9.5 years) tested for aBMD and TBS, 184 osteopenic women were identified...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29858633/association-of-trabecular-bone-score-tbs-and-prior-fracture-differs-among-minorities-in-nhanes-2005-2008
#4
R K Jain, T Vokes
The study investigates the association of trabecular bone score (TBS) and fractures among minority populations. In NHANES 2005-2008, TBS was associated with history of fractures in Caucasian subjects but demonstrated somewhat weaker associations in African American and Mexican American women. INTRODUCTION: Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA image, predicts fractures well in Caucasian (CA) and Asian populations but is less well studied in African American (AA) and Mexican American (MA) subjects...
June 1, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29806298/-comparative-study-of-different-concentrations-of-methicillin-resistant-staphylococcus-aureus-in-the-preparation-of-chronic-femoral-osteomyelitis-models
#5
Longlong Shao, Ping Zhen, Yonghai Ma, Dong Gong, Yunlong Wang
Objective: To investigate the appropriate concentration of methicillin-resistant Staphylococcus aureus (MRSA) in establishing chronic femoral osteomyelitis model in rabbits. Methods: Forty-eight adult New Zealand white rabbits were randomly divided into 6 groups with 8 rabbits in each group. Animals in groups B, C, D, E, and F were injected 1×10 9 , 1×10 8 , 1×10 7 , 1×10 6 , 1×10 5 CFU/mL MRSA on the location of 2 cm of the femoral supracondyle, respectively, and group A was injected with aseptic saline as a control...
April 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29802962/in-which-patients-does-lumbar-spine-trabecular-bone-score-tbs-have-the-largest-effect
#6
P Martineau, W D Leslie, H Johansson, N C Harvey, E V McCloskey, D Hans, J A Kanis
BACKGROUND: Lumbar spine TBS, a texture index derived from lumbar spine dual-energy x-ray absorptiometry (DXA) images, enhances fracture prediction. No studies to date have studied a broad range of clinical variables to determine which patients might experience the greatest benefit from the use of TBS. METHODS: Using the Manitoba BMD Registry, we identified 37,176 subjects with baseline DXA, FRAX®-based fracture probability, lumbar spine TBS, and minimum 5 years of observation...
May 23, 2018: Bone
https://www.readbyqxmd.com/read/29802743/fracture-healing-in-a-collagen-induced-arthritis-rat-model-radiology-and-histology-evidence
#7
Yiping Hu, Tiantian Zhang, Huan Huang, Wenxiang Cheng, Yuxiao Lai, Xueling Bai, Jianhai Chen, Ye Yue, Zhengtan Zheng, Chengshan Guo, Ling Qin, Peng Zhang
This research was designed to investigate the fracture healing pattern in a rheumatoid arthritis (RA) rat model. A mid-shaft femur fracture (RA + F) model and normal fracture (NF) model as control were established. Micro-CT, H&E staining, TB staining, SO staining, tartrate-resistant acid phosphates, and immunohistochemistry test were performed. In the micro-CT images and H&E stains, fracture gaps were evident in the RA + F group 4 and 8 weeks after fracture. In detail, the bone mineral density, the ratio of bone volume to tissue volume, and trabecular thickness of the RA + F group were significantly lower than those of the NF group at all time points...
May 26, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29788459/correlation-between-bone-quality-and-microvascular-damage-in-systemic-sclerosis-patients
#8
Barbara Ruaro, Andrea Casabella, Sabrina Paolino, Carmen Pizzorni, Elisa Alessandri, Chiara Seriolo, Giulia Botticella, Luigi Molfetta, Patrizio Odetti, Vanessa Smith, Maurizio Cutolo
Objectives: SSc patients are recognized as presenting an increased risk of altered bone mass. The aim of this study was to assess the bone quality, by trabecular bone score (TBS), in SSc patients in correlation with different levels of microvascular damage, as evaluated by nailfold videocapillaroscopy (NVC), and to compare the results regarding bone quality with RA patients and healthy subjects (CNT). Methods: Eighty-four SSc patients, 98 RA patients and 60 CNT, were studied...
May 18, 2018: Rheumatology
https://www.readbyqxmd.com/read/29781519/assessment-of-vertebral-microarchitecture-in-overt-and-mild-cushing-s-syndrome-using-trabecular-bone-score
#9
Helene Vinolas, Virginie Grouthier, Nadia Mehsen-Cetre, Amandine Boisson, Renaud Winzenrieth, Thierry Schaeverbeke, Charles Mesguich, Laurence Bordenave, Antoine Tabarin
OBJECTIVE: Osteoporotic fractures associated with Cushing's syndrome (CS) may occur despite normal bone mineral density (BMD). Few studies have described alterations in vertebral microarchitecture in glucocorticoid-treated patients and during CS. Trabecular bone score (TBS) estimates trabecular microarchitecture from dual-energy X-ray absorptiometry acquisitions. Our aim was to compare vertebral BMD and TBS in patients with overt CS and mild autonomous cortisol secretion (MACE), and following cure of overt CS...
May 21, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29776736/trabecular-bone-score-at-the-distal-femur-and-proximal-tibia-in-individuals-with-spinal-cord-injury
#10
Stacey Lobos, Anne Cooke, Gillian Simonett, Chester Ho, Steven K Boyd, W Brent Edwards
Rapid declines in bone mineral density (BMD) at the knee after spinal cord injury (SCI) are associated with an increased risk of fracture. Evaluation of bone quality using the trabecular bone score (TBS) may provide a complimentary measure to BMD assessment to examine bone health and fracture risk after SCI. The purpose of this study was to assess bone mineral density (BMD) and trabecular bone score (TBS) at the knee in individuals with and without SCI. Nine individuals with complete SCI (mean time since SCI 2...
April 24, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29775762/aortic-vascular-calcification-is-inversely-associated-with-the-trabecular-bone-score-in-patients-receiving-dialysis
#11
Jasna Aleksova, Samantha Kurniawan, Mirna Vucak-Dzumhur, Peter Kerr, Peter R Ebeling, Frances Milat, Grahame J Elder
INTRODUCTION: Progressive chronic kidney disease (CKD) confers a marked increase in risk for vascular calcification, cardiovascular disease, fracture and mortality, with likely contributing factors including dysregulated bone metabolism and mineral homeostasis. In general population studies, increased vascular calcification is directly related to mortality and inversely related to bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). In patients with CKD, abnormalities in turnover, mineralization and bone volume, reduce the ability of DXA to predict fracture...
May 15, 2018: Bone
https://www.readbyqxmd.com/read/29763384/the-effects-of-dihydroartemisinin-on-inflammatory-bowel-disease-related-bone-loss-in-a-rat-model
#12
Xingtao Ge, Zhijian Chen, Zhenjie Xu, Fang Lv, Kewei Zhang, Yu Yang
Bone loss is one of the important extra-intestinal manifestations in patients with inflammatory bowel diseases (IBDs). Compounds derived from natural products have been used to treat IBDs. However, the role of natural products on IBD-induced bone loss is not completely clarified. In the present study, we observed the effects of dihydroartemisinin (DHA), an antimalaria drug, on IBD and IBD-induced bone loss in a rat model. Chronic IBD model was established in Sprague-Dawley rats by giving them 2.5% dextran sodium sulfate in drinking water...
May 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29762165/improved-fracture-prediction-using-different-frax-adjustments-in-hiv-infected-women
#13
Jingyan Yang, Anjali Sharma, Qiuhu Shi, Kathryn Anastos, Mardge H Cohen, Elizabeth T Golub, Deborah Gustafson, Daniel Merenstein, Wendy J Mack, Phyllis C Tien, Jeri Nieves, Michael T Yin
OBJECTIVES: A Fracture risk assessment tool (FRAX®) using clinical risk factors (CRFs) alone underestimates fracture risk in HIV-infected men. Our objective was to determine whether accuracy of FRAX would be improved by considering HIV as a cause of secondary osteoporosis, and further improved with addition of DXA parameters in HIV-infected women. DESIGN: Subgroup analysis of Women's Interagency HIV Study. METHODS: We included 1148 women (900 HIV-infected and 248 uninfected) over age 40 with data to approximate FRAX CRFs and 10-year observational data for incident fragility fractures; 181 (20%) HIV-infected women had DXA data...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29758361/bone-accrual-in-oligo-amenorrheic-athletes-eumenorrheic-athletes-and-non-athletes
#14
Vibha Singhal, Karen Campoverde Reyes, Brooke Pfister, Kathryn Ackerman, Meghan Slattery, Katherine Cooper, Alexander Toth, Nupur Gupta, Mark Goldstein, Kamryn Eddy, Madhusmita Misra
BACKGROUND: Mechanical loading improves bone mineral density (BMD) and strength while decreasing fracture risk. Cross-sectional studies show that exercise advantage is lost in oligo-amenorrheic athletes (OA). Longitudinal studies examining the opposing effects of exercise and hypogonadism on bone are lacking in adolescents/young adults. OBJECTIVE: Evaluate differences in bone accrual over 12 months in OA, eumenorrheic athletes (EA) and non-athletes (NA). We hypothesized that bone accrual would be lower in OA than EA and NA, with differences most pronounced at non-weight bearing trabecular sites...
May 11, 2018: Bone
https://www.readbyqxmd.com/read/29750829/robust-trabecular-microstructure-in-type-2-diabetes-revealed-by-individual-trabecula-segmentation-analysis-of-hr-pqct-images
#15
Jessica F Starr, Leonardo C Bandeira, Sanchita Agarwal, Ankit M Shah, Kyle K Nishiyama, Yizhong Hu, Donald J McMahon, X Edward Guo, Shonni J Silverberg, Mishaela R Rubin
Type 2 diabetes (T2D) patients have an increased fracture risk, which may be partly explained by compromised bone microarchitecture within the cortical bone compartment. Data on trabecular bone parameters in T2D are contradictory. By high resolution peripheral quantitative computed tomography (HR-pQCT) trabecular microarchitecture is preserved, yet larger trabecular holes are detected in T2D by MRI and DXA-based trabecular bone scores (TBS) are abnormal. To determine if there are differences in trabecular microstructure, connectivity and alignment in postmenopausal women with T2D as compared to controls, we performed individual trabecula segmentation (ITS) analysis on high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the distal radius and tibia in 92 women with (n = 42) and without (n = 50) T2D...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29739679/low-trabecular-bone-score-in-adolescent-female-inpatients-with-anorexia-nervosa
#16
Yael Levy-Shraga, Liana Tripto-Shkolnik, Dana David, Iris Vered, Daniel Stein, Dalit Modan-Moses
BACKGROUND & AIMS: Trabecular bone score (TBS) is an emerging technology that provides information regarding bone microarchitecture. A recent study showed that in healthy girls normal TBS (≥1.35) was achieved within the first year post-menarche. The aims of our study was to assess TBS in adolescents with anorexia nervosa (AN) and to evaluate correlations with clinical, laboratory and densitometric variables. METHODS: A cohort study of 208 adolescent females (mean age 15...
April 26, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29736760/assessment-of-bone-quality-in-patients-with-diabetes-mellitus
#17
REVIEW
N Jiang, W Xia
Substantial evidence exists that diabetes mellitus is associated with an increased risk of osteoporotic fractures. Low bone strength as well as bone extrinsic factors are probably contributing to the increased bone fragility in diabetes. Bone density and quality are important determinants of bone strength. Although bone mineral density (BMD) and the fracture risk assessment tool (FRAX) are very useful clinical tools in assessing bone strength, they may underestimate the fracture risk in diabetes mellitus. Through advances in new technologies such as trabecular bone score (TBS) and peripheral quantitative computed tomography (pQCT), we can better assess the bone quality and fracture risk of patients with diabetes mellitus...
May 7, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29696556/long-term-effect-of-testosterone-replacement-therapy-on-bone-in-hypogonadal-men-with-klinefelter-syndrome
#18
N Tahani, L Nieddu, G Prossomariti, M Spaziani, S Granato, F Carlomagno, A Anzuini, A Lenzi, A F Radicioni, E Romagnoli
PURPOSE: To assess different aspects of bone damage in untreated adult patients with Klinefelter Syndrome (KS) before and during testosterone replacement therapy (TRT). METHODS: Fifteen untreated hypogonadal men with KS and 26 control subjects (C) matched for age and BMI were recruited. Sex hormone levels were measured in all subjects. Lumbar spine (LS) and femoral (neck: FN and total hip: TH) bone mineral density (BMD), trabecular bone score (TBS), hip structure analysis (HSA) and fat measures (percentage of fat mass, android/gynoid ratio and visceral adipose tissue) were evaluated by DEXA...
April 25, 2018: Endocrine
https://www.readbyqxmd.com/read/29693762/growth-body-composition-and-bone-density-following-pediatric-liver-transplantation
#19
Amin Sheikh, Tim Cundy, Helen Maria Evans
Patients transplanted for cholestatic liver disease are often significantly fat-soluble vitamin deficient and malnourished pretransplant, with significant corticosteroid exposure post-transplant, with increasing evidence of obesity and metabolic syndrome post-LT. Our study aimed to assess growth, body composition, and BMD in patients post-pediatric LT. Body composition and bone densitometry scans were performed on 21 patients. Pre- and post-transplant anthropometric data were analyzed. Bone health was assessed using serum ALP, calcium, phosphate, and procollagen-1-N-peptide levels...
April 24, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29685494/trabecular-bone-score-is-a-valuable-addition-to-bone-mineral-density-for-bone-quality-assessment-in-older-mexican-american-women-with-type-2-diabetes
#20
Nahid Rianon, Catherine G Ambrose, Maryam Buni, Gordon Watt, Carlos Reyes-Ortiz, Miryoung Lee, Joseph McCormick, Susan Fisher-Hoch
Altered bone quality due to the underlying metabolic changes of type 2 diabetes (T2D) has been hypothesized to affect bone strength, leading to increased fracture risk in patients with T2D. Lumbar spine trabecular bone score (LS-TBS), an indirect measure of trabecular microarchitecture, provides information on bone quality and has been associated with T2D. However, trabecular bone score (TBS) is also affected by demographic patterns and body size, and is expected to be different in people from various ethnic or racial backgrounds...
March 27, 2018: Journal of Clinical Densitometry
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