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https://www.readbyqxmd.com/read/29051042/bone-disease-in-primary-hyperparathyroidism
#1
Polyzois Makras, Athanasios D Anastasilakis
Primary hyperparathyroidism (PHPT) is a disease of high bone turnover, decreased bone mineral density (BMD) especially at cortical sites, and increased risk of fractures at all skeletal sites. Early diagnosis during the last decades resulted in milder forms of bone involvement. New methods of imaging and validation such as high resolution peripheral quantitative computed tomography and trabecular bone score provide evidence of disturbed bone microarchitecture and explain further the increased risk of fractures at both cortical and trabecular skeletal sites...
October 16, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29046970/a-focused-evaluation-of-lumbar-spine-trabecular-bone-score-in-the-first-year-post-menarche
#2
Jodi N Dowthwaite, R Winzenrieth, N Binkley, D Krueger, T A Scerpella
Trabecular bone score, an index of lumbar spine trabecular texture, has not been explored fully in adolescent girls. Our cross-sectional analysis supported the hypothesis that "adult normal" trabecular bone score has been achieved by the end of the first year post-menarche, providing a potential screening tool, independent from bone density. INTRODUCTION: Trabecular bone score (TBS) evaluates lumbar spine (LS) trabecular texture from DXA images. Limited evidence suggests low TBS in pre-pubertal girls...
October 18, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29024546/bone-reading-to-predict-the-future
#3
EDITORIAL
Martin Englund, Aleksandra Turkiewicz, Pawel Podsiadlo
Human skeletal remains may provide information about health status and injuries from hundreds of thousands of years ago. However, the bones in living individuals have the potential to tell us something about future health as well. In the current issue of Arthritis & Rheumatology, Kraus et al report data of prediction of osteoarthritis (OA) progression using tibial subchondral trabecular bone texture (TBT) from plain knee radiographs (1). The ability of medial TBT was assessed to predict pain progression (an increase in WOMAC score), radiographic OA progression (a loss in joint space width [JSW]), and OA status (a combination of pain and radiographic OA progression), over 24-48 months...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29024470/predictive-validity-of-radiographic-trabecular-bone-texture-in-knee-oa-the-oarsi-fnih-oa-biomarkers-consortium
#4
Virginia Byers Kraus, Jamie E Collins, H Cecil Charles, Carl F Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, Steve Hoffmann, Frank Roemer, Ali Guermazi, David J Hunter
OBJECTIVE: To evaluate radiographic subchondral trabecular bone texture (TBT) as a predictor of clinically relevant osteoarthritis (OA) progression (combination of symptom and structure worsening). METHODS: The FNIH OA Biomarkers Consortium undertook a study of progressive knee OA cases (n=194 knees with both radiographic and pain progression over 24-48 months) and comparators (n=406 OA knees not meeting the case definition). TBT parameters were extracted from a medial subchondral tibial region of interest by fractal signature analysis of radiographs using a validated semi-automated software...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29018923/is-drug-induced-bone-loss-acceptable-in-premenopausal-women-a-practical-fracture-risk-modeling-exercise
#5
N Binkley, R Besuyen, T Fuerst, L Skillern, D Hans
Premenopausal bone loss increases fracture risk later in life. Depending on peak values, varying degrees of bone mass and microarchitectural loss can be tolerated. We suggest that risk-benefit assessments of drugs that cause premenopausal bone loss be individualized considering baseline status and subsequent BMD and TBS loss. INTRODUCTION: It is logical that drug-induced loss of bone mass and microarchitecture in young adults increase fracture risk later in life. However, no existing data quantify how drug-induced bone loss in younger adults impacts fracture risk later in life...
October 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29017892/muscle-functions-and-bone-strength-are-impaired-in-adolescents-with-type-1-diabetes
#6
Klara Maratova, Ondrej Soucek, Jana Matyskova, Zdenek Hlavka, Lenka Petruzelkova, Barbora Obermannova, Stepanka Pruhova, Stanislava Kolouskova, Zdenek Sumnik
BACKGROUND: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system. METHODS: Ninety-five children and adolescents (59 boys and 36 girls, mean age 16...
October 7, 2017: Bone
https://www.readbyqxmd.com/read/28988401/the-trabecular-bone-score-tbs-complements-dxa-and-the-frax-as-a-fracture-risk-assessment-tool-in-routine-clinical-practice
#7
REVIEW
Didier Hans, Emőke Šteňová, Olivier Lamy
PURPOSE OF THE REVIEW: There is an increasing body of evidence that the trabecular bone score (TBS), a surrogate of bone microarchitecture extracted from spine DXA, could play an important role in the management of patients with osteoporosis or at risk of fracture. The current paper reviews this published body of scientific literature on TBS and answers the most relevant clinical questions. RECENT FINDINGS: TBS has repeatedly been proven to be predictive of fragility fractures, current and future, and this is largely independent of BMD, CRF, and the FRAX, and when used in conjunction with any one of these measures, it consistently enhances their accuracy...
October 7, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28985103/low-bone-mineral-density-in-male-athletes-is-associated-with-bone-stress-injuries-at-anatomic-sites-with-greater-trabecular-composition
#8
Adam S Tenforde, Allyson L Parziale, Kristin L Popp, Kathryn E Ackerman
BACKGROUND: While sports participation is often associated with health benefits, a subset of athletes may develop impaired bone health. Bone stress injuries (BSIs) are a common overuse injury in athletes; site of injury has been shown to relate to underlying bone health in female athletes. Hypothesis/Purpose: This case series characterizes the association of type of sports participation and anatomic site of BSIs with low bone mineral density (BMD), defined as BMD Z-score <-1.0. Similar to female athletes, it was hypothesized that male athletes who participate in running and sustain BSIs in sites of higher trabecular bone content would be more likely to have low BMD...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28978352/assessment-of-3-month-changes-in-bone-microstructure-under-anti-tnf%C3%AE-therapy-in-patients-with-rheumatoid-arthritis-using-high-resolution-peripheral-quantitative-computed-tomography-hr-pqct
#9
Tomohiro Shimizu, Hyo Jin Choi, Ursula Heilmeier, Matthew Tanaka, Andrew J Burghardt, Jingshan Gong, Nattagan Chanchek, Thomas M Link, Jonathan Graf, John B Imboden, Xiaojuan Li
BACKGROUND: Although one study showed minimal progression of erosions in patients with rheumatoid arthritis (RA) one year after TNFα inhibition therapy, no studies have investigated very early bone changes after initiation of anti-TNFα treatment. We investigated the effects of 3-month anti-TNFα treatment on bone erosion progression and bone microarchitecture in RA patients using high-resolution peripheral quantitative computed tomography (HR-pQCT). METHODS: Patients with RA (n = 27) (17 in the anti-TNFα and 10 in the MTX-only group) underwent assessment of disease activity score in 28 joints (DAS-28), radiographs, 3-T magnetic resonance imaging (MRI) and HR-pQCT of metacarpophalangeal and wrist joints at baseline and 3 months...
October 4, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28974461/bone-replaces-articular-cartilage-in-the-rat-knee-joint-after-prolonged-immobilization
#10
T M Campbell, K Reilly, O Laneuville, H Uhthoff, G Trudel
BACKGROUND: Lost joint range of motion (ROM) is common in chronic osteoarthritis, alters regional weight-bearing across the articular surfaces, and contributes to loss of cartilage and bone alterations. Limited data exist on the regional effects on joints subjected to chronic losses of ROM. OBJECTIVE: To characterize the regional replacement by bone as part of articular cartilage degeneration after prolonged immobilization. METHODS: Eleven rat knees were rigidly-immobilized in flexion for 32weeks with contralateral and sham-operated (n=6) knees as controls...
September 30, 2017: Bone
https://www.readbyqxmd.com/read/28968875/effects-of-tofacitinib-in-early-arthritis-induced-bone-loss-in-an-adjuvant-induced-arthritis-rat-model
#11
Bruno Vidal, Rita Cascão, Mikko A J Finnilä, Inês P Lopes, Vânia G da Glória, Simo Saarakkala, Peter Zioupos, Helena Canhão, João Eurico Fonseca
Objectives: The main goal of this work was to analyse how treatment intervention with tofacitinib prevents the early disturbances of bone structure and mechanics in the rat model of adjuvant-induced arthritis. This is the first study to access the impact of tofacitinib on the skeletal bone effects of inflammation. Methods: Fifty Wistar rats with adjuvant-induced arthritis were randomly housed in experimental groups, as follows: non-arthritic healthy group (n = 20); arthritic non-treated group (n = 20); and 10 animals undergoing tofacitinib treatment...
August 10, 2017: Rheumatology
https://www.readbyqxmd.com/read/28965154/trabecular-bone-score-in-men-and-women-with-impaired-fasting-glucose-and-diabetes
#12
Kara L Holloway, Lelia L F De Abreu, Didier Hans, Mark A Kotowicz, Muhammad A Sajjad, Natalie K Hyde, Julie A Pasco
Diabetes is associated with increased skeletal fragility, despite higher bone mineral density (BMD). Alternative measures are necessary to more accurately determine fracture risk in individuals with diabetes. Therefore, we aimed to describe the relationship between trabecular bone score (TBS) and normoglycaemia, impaired fasting glucose (IFG) and diabetes and determine whether TBS-adjusted FRAX (Aus) score differed between these groups. This study included 555 men (68.7 ± 12.2 years) and 514 women (62.0 ± 12...
September 30, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28963163/cemented-total-hip-arthroplasty-following-acetabular-fracture
#13
C E H Scott, D MacDonald, M Moran, T O White, J T Patton, J F Keating
AIMS: To evaluate the outcomes of cemented total hip arthroplasty (THA) following a fracture of the acetabulum, with evaluation of risk factors and comparison with a patient group with no history of fracture. PATIENTS AND METHODS: Between 1992 and 2016, 49 patients (33 male) with mean age of 57 years (25 to 87) underwent cemented THA at a mean of 6.5 years (0.1 to 25) following acetabular fracture. A total of 38 had undergone surgical fixation and 11 had been treated non-operatively; 13 patients died at a mean of 10...
October 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28963079/comparisons-of-tbs-and-lumbar-spine-bmd-in-the-associations-with-vertebral-fractures-according-to-the-t-scores-a-cross-sectional-observation
#14
Jie-Eun Lee, Kyoung Min Kim, Lee-Kyung Kim, Kyong Young Kim, Tae Jung Oh, Jae Hoon Moon, Sung Hee Choi, Soo Lim, Sang Wan Kim, Chan Soo Shin, Hak Chul Jang
Trabecular bone score (TBS) is a parameter of bone quality that has been shown to be related to vertebral fractures. This study aimed to analyze the difference in discriminatory power of TBS for vertebral fractures according to the bone mineral density (BMD) T-score. Areal BMD at the lumbar spine (LS, L1-L4), femur neck (FN) and total hip were assessed using dual x-ray absorptiometry (Discovery W, Hologic, Bedford, MA) in 929 women aged 50years or older. TBS was analyzed using iNsight software (Med-Imaps, Pessac, France)...
September 28, 2017: Bone
https://www.readbyqxmd.com/read/28960489/evaluation-of-radius-microstructure-and-areal-bone-mineral-density-improves-fracture-prediction-in-postmenopausal-women
#15
Emmanuel Biver, Claire Durosier-Izart, Thierry Chevalley, Bert van Rietbergen, René Rizzoli, Serge Ferrari
A majority of low-trauma fractures occurs in subjects with only moderate decrease of areal bone mineral density (aBMD), i.e osteopenia, assessed by dual-energy X-ray absorptiometry (DXA), or low fracture probability assessed by FRAX. We investigated whether peripheral bone microstructure and estimated strength improve the prediction of incident fractures beyond central DXA and FRAX. In this population-based study of 740 postmenopausal women (age 65.0 ± 1.4 years) from the Geneva Retirees Cohort (ISRCTN registry 11865958), we assessed at baseline cortical (Ct) and trabecular (Tb) volumetric bone mineral density (vBMD) and microstructure by peripheral quantitative computed tomography (HR-pQCT), bone strength by micro-finite element analysis, aBMD and trabecular bone score (TBS) by DXA, and FRAX fracture probability...
September 28, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28955682/acetabular-defect-reconstruction-with-trabecular-metal-augments-study-with-minimum-one-year-follow-up
#16
Chirayu Dwivedi, Sandeep Gokhale, Hyun Gon Khim, Jeon Keon Oh, Won Yong Shon
PURPOSE: High rates of mechanical failure have been reported in type III acetabular defects. Recently porous trabecular metal augments have been introduced with, excellent biomechanical characteristics and biocompatibility, allowing early stability and greater bone ingrowth. The aim of the study was to assess the short term clinical and radiological outcome of the trabecular metal augments. MATERIALS AND METHODS: We performed, 22 revision total hip arthroplasties (THA) and 6 primary THA (total 28) using trabecular metal augments to reconstruct acetabular defect between 2011 to 2015...
September 2017: Hip & Pelvis
https://www.readbyqxmd.com/read/28940052/prediction-of-major-osteoporotic-and-hip-fractures-in-australian-men-using-frax-scores-adjusted-with-trabecular-bone-score
#17
K L Holloway, M Mohebbi, A G Betson, D Hans, N K Hyde, S L Brennan-Olsen, M A Kotowicz, J A Pasco
There was no significant difference between the areas under receiver operating characteristics (AUROCs) and diagnostic indexes (sensitivity, specificity, positive predictive value, negative predictive value) for either major osteoporotic or hip fracture FRAX scores when comparing the unadjusted and trabecular bone score (TBS)-adjusted scores. INTRODUCTION: FRAX 10-year probability of fracture can be calculated with adjustment for the TBS. Studies have shown that TBS can improve FRAX assessments in some populations...
September 23, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28936199/bone-status-in-a-patient-with-insulin-like-growth-factor-1-receptor-deletion-syndrome-bone-quality-and-structure-evaluation-using-dual-energy-x-ray-absorptiometry-peripheral-quantitative-computed-tomography-and-quantitative-ultrasonography
#18
Paola Pelosi, Elisabetta Lapi, Loredana Cavalli, Alberto Verrotti, Marilena Pantaleo, Maurizio de Martino, Stefano Stagi
Haploinsufficiency of the insulin-like growth factor (IGF)-1 receptor (IGF1R) gene is a rare, probably under-diagnosed, cause of short stature. However, the effects of IGF1R haploinsufficiency on glucose metabolism, bone status, and metabolism have rarely been investigated. We report the case of a patient referred to our center at the age of 18 months for short stature, failure to thrive, and Silver-Russell-like phenotype. Genetic analysis did not show hypomethylation of the 11p15.5 region or uniparental disomy of chromosome 7...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28935435/subchondral-tibial-bone-texture-predicts-the-incidence-of-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#19
T Janvier, R Jennane, H Toumi, E Lespessailles
OBJECTIVES: To evaluate whether trabecular bone texture (TBT) parameters measured on computed radiographs (CR) could predict the onset of radiographic knee osteoarthritis (OA). MATERIALS AND METHODS: Subjects from the Osteoarthritis Initiative (OAI) with no sign of radiographic OA at baseline were included. Cases that developed either a global radiographic OA defined by the Kellgren-Lawrence (KL) scale, a joint space narrowing (JSN) or tibial osteophytes (TOS) were compared with the controls with no changes after 48 months of follow-up...
September 19, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28933329/-mid-term-to-long-term-results-of-revision-total-hip-arthroplasty-using-the-oval-shaped-acetabular-cup-tc-type
#20
E Šťastný, T Trč, J Frýdl, Z Kopečný, T Philippou, J Lisý
INTRODUCTION The purpose of our paper is to evaluate the mid-term to long-term results and to confirm the basic criteria of a high-quality revision implant: safe bridging of bone defects, achievement of reliable primary fixation of revision acetabular cup, achievement of good secondary stability with documentable osteointegration of cup and demonstration of remodelling of transplanted bone tissue in the area of defects and in spaces between the implant ribs. MATERIAL AND METHODS Altogether 36 patients (38 cups) were evaluated who had undergone revision hip arthroplasty in the period from 2004 to 2010...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
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