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https://www.readbyqxmd.com/read/29474654/preliminary-investigation-of-radiation-dose-to-patients-from-cardiovascular-interventional-procedures-in-tanzania
#1
J E Ngaile, P K Msaki, R Mvungi, L J Schreiner
Although contemporary cardiac X-ray exams are typically set so benefits outweighs the risk, the growing use and increasing complexity of the cardiovascular interventional radiological (CVIR) procedures does increase the risk of radiation-related tissue effects and stochastic effects to the individual patients and the population. In view of these radiological concerns there is a need to investigate factors that influence the doses received by the patients and enable optimisation needed. The air kerma area product (KAP), cumulative air kerma (CAK) and fluoroscopy time (FT) to patients from two major CVIR procedures: coronary angiography (CA) and percutaneous coronary interventions (PCI), were obtained from two major hospitals in Tanzania...
February 21, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29474466/preclinical-pharmacology-of-azd9977-a-novel-mineralocorticoid-receptor-modulator-separating-organ-protection-from-effects-on-electrolyte-excretion
#2
Krister Bamberg, Ulrika Johansson, Karl Edman, Lena William-Olsson, Susanna Myhre, Anders Gunnarsson, Stefan Geschwindner, Anna Aagaard, Anna Björnson Granqvist, Frédéric Jaisser, Yufeng Huang, Kenneth L Granberg, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner
Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperkalemia risk. Here we present evidence that AZD9977, a first-in-class MR modulator shows cardio-renal protection despite a mechanism-based reduced liability to cause hyperkalemia. AZD9977 in vitro potency and binding mode to MR were characterized using reporter gene, binding, cofactor recruitment assays and X-ray crystallopgraphy...
2018: PloS One
https://www.readbyqxmd.com/read/29474364/%C3%AE-glucuronidase-use-as-a-single-internal-control-gene-may-confound-analysis-in-fmr1-mrna-toxicity-studies
#3
Claudine M Kraan, Kim M Cornish, Quang M Bui, Xin Li, Howard R Slater, David E Godler
Relationships between Fragile X Mental Retardation 1 (FMR1) mRNA levels in blood and intragenic FMR1 CGG triplet expansions support the pathogenic role of RNA gain of function toxicity in premutation (PM: 55-199 CGGs) related disorders. Real-time PCR (RT-PCR) studies reporting these findings normalised FMR1 mRNA level to a single internal control gene called β-glucuronidase (GUS). This study evaluated FMR1 mRNA-CGG correlations in 33 PM and 33 age- and IQ-matched control females using three normalisation strategies in peripheral blood mononuclear cells (PBMCs): (i) GUS as a single internal control; (ii) the mean of GUS, Eukaryotic Translation Initiation Factor 4A2 (EIF4A2) and succinate dehydrogenase complex flavoprotein subunit A (SDHA); and (iii) the mean of EIF4A2 and SDHA (with no contribution from GUS)...
2018: PloS One
https://www.readbyqxmd.com/read/29474123/neuroprotective-effects-of-the-methanol-extract-of-kimchi-a-korean-fermented-vegetable-food-mediated-via-suppression-of-endoplasmic-reticulum-stress-and-caspase-cascade-pathways-in-high-cholesterol-diet-fed-mice
#4
Serim Kim, Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
Endoplasmic reticulum (ER) stress-related unfolded peptide accumulation is closely associated with the development of neurodegenerative diseases known as protein misfolding disorders. The antioxidative properties of kimchi, a traditional Korean fermented vegetable dish, have been well established. In this study, the neuroprotective effects of the kimchi methanol extract (KME) were examined in high-cholesterol diet (HCD)-fed mice. The animals were fed a HCD, with oral administration of either KME (KME group, 200 mg·kg bw-1 ·day-1 , n = 10) or distilled water (Control group, n = 10) for 8 weeks...
February 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29473999/melanoma-cases-demonstrate-increased-carrier-frequency-of-phenylketonuria-hyperphenylalanemia-mutations
#5
Joshua Arbesman, Sairekha Ravichandran, Pauline Funchain, Cheryl L Thompson
Identifying novel melanoma genetic risk factors informs screening and prevention efforts. Mutations in the phenylalanine hydroxylase gene (the causative gene in phenylketonuria) lead to reduced pigmentation in untreated phenylketonuria patients, and reduced pigmentation is associated with greater melanoma risk. Therefore, we sought to characterize the relationship between phenylketonuria carrier status and melanoma risk. Using National Newborn Screening Reports, we determined the United States phenylketonuria/hyperphenylalanemia carrier frequency in Caucasians to be 1...
February 23, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29472917/senescent-t-cells-promote-bone-loss-in-rheumatoid-arthritis
#6
Johannes Fessler, Rusmir Husic, Verena Schwetz, Elisabeth Lerchbaum, Felix Aberer, Patrizia Fasching, Anja Ficjan, Barbara Obermayer-Pietsch, Christina Duftner, Winfried Graninger, Martin Helmut Stradner, Christian Dejaco
Objective: T-cells are critical players in the pathogenesis of osteoporosis in patients with rheumatoid arthritis (RA). Premature senescence of lymphocytes including the accumulation of senescent CD4+ T-cells is a hallmark feature of RA. Whether T-cell senescence is associated with bone loss in RA patients is elusive so far. Methods: This includes a prospective study of consecutive patients with RA ( n  = 107), patients with primary osteopenia/-porosis ( n  = 75), and healthy individuals ( n  = 38)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472641/bigr-is-a-sulfide-sensor-that-regulates-a-sulfur-transferase-dioxygenase-required-for-aerobic-respiration-of-plant-bacteria-under-sulfide-stress
#7
Nayara Patricia Vieira de Lira, Bianca Alves Pauletti, Ana Carolina Marques, Carlos Alberto Perez, Raquel Caserta, Alessandra Alves de Souza, Aníbal Eugênio Vercesi, Adriana Franco Paes Leme, Celso Eduardo Benedetti
To cope with toxic levels of H2 S, the plant pathogens Xylella fastidiosa and Agrobacterium tumefaciens employ the bigR operon to oxidize H2 S into sulfite. The bigR operon is regulated by the transcriptional repressor BigR and it encodes a bifunctional sulfur transferase (ST) and sulfur dioxygenase (SDO) enzyme, Blh, required for H2 S oxidation and bacterial growth under hypoxia. However, how Blh operates to enhance bacterial survival under hypoxia and how BigR is deactivated to derepress operon transcription is unknown...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29472529/a-novel-microrna-identified-in-hepatocellular-carcinomas-is-responsive-to-lef1-and-facilitates-proliferation-and-epithelial-mesenchymal-transition-via-targeting-of-nfix
#8
Yaqi Hu, Xu Guo, Jinxia Wang, Yankun Liu, Huijie Gao, Hongxia Fan, Xiangyang Nong, Xi Yang, Min Liu, Shengping Li, Hua Tang
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers. It has been demonstrated that various cellular microRNAs (miRNAs) play an important role in HCC development. Here, we analyzed the miRNA profile in HCC tissues by Solexa sequencing, and we identified a novel microRNA, miR-HCC1, which is upregulated in HCC tissues. Further experiments showed that miR-HCC1 promoted HCC cell proliferation in vivo and in vitro, and migration and invasion resulting from the epithelial-mesenchymal transition (EMT) process...
February 23, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29472355/use-of-thrombin-generation-assay-to-personalize-treatment-of-breakthrough-bleeds-in-a-patient-with-hemophilia-and-inhibitors-receiving-prophylaxis-with-emicizumab
#9
Yesim Dargaud, Anne Lienhart, Maissaa Janbain, Sandra LeQuellec, Nathalie Enjolras, Claude Negrier
Emicizumab is a recombinant, humanized, bispecific, monoclonal antibody that bridges activated factor IX and factor X to restore the function of deficient factor VIII. Treatment of bleeding in patients with hemophilia and inhibitors involves the use of bypassing agents (BPA).These molecules are also used for the management of breakthrough bleeds in patients on prophylaxis with emicizumab, with increased concerns about the risks of combining two procoagulant drugs. Using thrombin generation assay, we tailored the dosage of activated prothrombin complex concentrate (APCC) and successfully treated an acute spontaneous arterial bleeding in a patient on prophylaxis with emicizumab 1...
February 22, 2018: Haematologica
https://www.readbyqxmd.com/read/29471779/characterizing-adversity-of-lysosomal-accumulation-in-nonclinical-toxicity-studies-results-from-the-5th-estp-international-expert-workshop
#10
B Lenz, A Braendli-Baiocco, J Engelhardt, P Fant, H Fischer, S Francke, R Fukuda, S Gröters, T Harada, H Harleman, W Kaufmann, S Kustermann, T Nolte, X Palazzi, G Pohlmeyer-Esch, A Popp, A Romeike, A Schulte, B Silva Lima, L Tomlinson, J Willard, C E Wood, M Yoshida
Lysosomes have a central role in cellular catabolism, trafficking, and processing of foreign particles. Accumulation of endogenous and exogenous materials in lysosomes represents a common finding in nonclinical toxicity studies. Histologically, these accumulations often lack distinctive features indicative of lysosomal or cellular dysfunction, making it difficult to consistently interpret and assign adverse dose levels. To help address this issue, the European Society of Toxicologic Pathology organized a workshop where representative types of lysosomal accumulation induced by pharmaceuticals and environmental chemicals were presented and discussed...
February 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29471731/the-role-of-pelvis-thorax-coupling-in-controlling-within-golf-club-swing-speed
#11
Peter F Lamb, Todd C Pataky
Pelvis-thorax coordination has been recognised to be associated with swing speed. Increasing angular separation between the pelvis and thorax has been thought to initiate the stretch shortening cycle and lead to increased clubhead speed. The purpose of this study was to determine whether pelvis-thorax coupling played a significant role in regulating clubhead speed, in a group of low-handicap golfers (mean handicap = 4.1). Sixteen participants played shots to target distances determined based on their typical 5- and 6-iron shot distances...
February 23, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29471560/knochensarkome
#12
Jendrik Hardes, Georg Gosheger, Timo Budny
Bone sarcomas are extremely rare representing approximately 0.2% among all cancer types. Due to the rarity of these tumors both the patients and the physicians can overlook or misinterpret the first often unspecific symptoms of these tumors (pain, limping and swelling). Therefore, radiographic examination (X-ray and/or MRI) of the involved region in case of inexplicable symptoms is strongly recommended. The most common primary malignant bone tumor entity is osteosarcoma, followed by chondrosarcoma and Ewing sarcoma...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29471430/gwas-identifies-two-novel-colorectal-cancer-loci-at-16q24-1-and-20q13-12
#13
Chizu Tanikawa, Yoichiro Kamatani, Atsushi Takahashi, Yukihide Momozawa, Karine Leveque, Satoshi Nagayama, Koshi Mimori, Masaki Mori, Hideshi Ishii, Johji Inazawa, Jun Yasuda, Akito Tsuboi, Atsushi Shimizu, Makoto Sasaki, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane, Mariko Naito, Kenji Wakai, Teruhide Koyama, Toshiro Takezaki, Koichiro Yuji, Yoshinori Murakami, Yusuke Nakamura, Michiaki Kubo, Koichi Matsuda
Colorectal cancer is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 colorectal cancer loci. However, most of the previous studies were conducted in European populations, and host genetic factors among Japanese population are largely remained to be identified. To identify novel loci in the Japanese population, here, we performed a large-scale GWAS using 6,692 cases and 27,178 controls followed by a replication analysis using more than 11,000 case-control samples...
February 17, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29471202/conductive-micropatterned-polyurethane-films-as-tissue-engineering-scaffolds-for-schwann-cells-and-pc12-cells
#14
Yaobin Wu, Ling Wang, Tianli Hu, Peter X Ma, Baolin Guo
Controlling cellular alignment and elongation has been demonstrated as an important parameter for developing nerve tissue engineering scaffolds. Many approaches have been developed to guide cellular orientation for nerve regeneration such as micropatterning techniques. However, most of materials used for developing micropatterning scaffolds lack of bioactivity and biofunctionability. Here we present a functional conductive micropatterned scaffold based on bioactive conductive biodegradable polyurethane prepared using a micro-molding technique...
February 13, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29471015/biological-profiling-of-plasma-neuropeptide-y-in-relation-to-posttraumatic-stress-symptoms-in-two-combat-cohorts
#15
Alieke Reijnen, Elbert Geuze, Iris Eekhout, Adam X Maihofer, Caroline M Nievergelt, Dewleen G Baker, Eric Vermetten
In order to decrease the risk of developing stress-related disorders after military deployment, biological vulnerability factors should be identified. Neuropeptide Y (NPY) is a peptide neurotransmitter that is associated with modulation of the stress response. Using the data of two longitudinal prospective cohort studies (N = 892 and N = 2427), plasma NPY (pNPY) was assessed as a possible susceptibility biomarker for the development of PTSD symptoms over time. Data collection started prior to deployment and follow-up assessments were completed up to two years after deployment...
February 19, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29470841/disease-duration-and-stage-influence-bone-microstructure-in-patients-with-primary-biliary-cholangitis
#16
Tobias Schmidt, Constantin Schmidt, Felix N Schmidt, Sebastian Butscheidt, Haider Mussawy, Jan Hubert, Thelonius Hawellek, Nicola Oehler, Florian Barvencik, Ansgar W Lohse, Thorsten Schinke, Christoph Schramm, Michael Amling, Tim Rolvien
Primary biliary cholangitis (PBC) is known to be a major risk factor for osteoporosis reflected by a reduction of bone mineral density (BMD). However, both the extent of the macro- and microstructural alterations of bone as well as the causative factors are unknown. We have retrospectively analyzed a total of 96 patients with PBC and 53 healthy controls matched for age, sex and body mass index. In addition to dual-energy X-ray absorptiometry (DXA) measurements at the lumbar spine and hip, high-resolution peripheral quantitative computed tomography (HR-pQCT) was used to assess the geometric, volumetric and microstructural changes of bone at the distal radius and tibia...
February 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29470693/anti-inflammatory-anti-rheumatic-and-analgesic-activities-of-2-5-mercapto-1-3-4-oxadiazol-2-yl-n-propylbenzenesulphonamide-mopbs-in-rodents
#17
Hina Rasheed, Ruqayya Afridi, Ashraf Ullah Khan, Muhammad Zia Ullah, Sidra Khalid, Ayesha Atiq, Humaira Kashif, Muhammad Naeem Ahmed, Yeong Shik Kim, Salman Khan
Chronic inflammation is pathologically associated with various clinical conditions such as rheumatoid arthritis. Several anti-inflammatory and analgesic drugs currently available in market presents a wide range of problems. Therefore, the current study was aimed to evaluate anti-inflammatory and analgesic activities of newly synthesized compound 2-(5-mercapto-1,3,4-oxadiazol-2-yl)-N-propylbenzenesulphonamide (MOPBS). Carrageenan and CFA-induced models were developed for evaluation of anti-inflammatory and analgesic activity...
February 22, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29470364/resistance-training-is-associated-with-higher-bone-mineral-density-among-young-adult-male-distance-runners-independent-of-physiological-factors
#18
Anthony A Duplanty, Danielle E Levitt, David W Hill, Brian K McFarlin, Nancy M DiMarco, Jakob L Vingren
Low bone mineral density (BMD) in male distance runners is common and could be modulated by a host of biomarkers involved in the dynamic balance of bone tissue. In contrast, resistance training can increase BMD; however, the efficacy of resistance training in protecting BMD in distance runners has not been elucidated. OBJECTIVE: To investigate the relationship between resistance training, testosterone and bone metabolism biomarker concentrations, and BMD in young adult male distance runners...
February 20, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29470233/can-a-nomogram-help-to-predict-the-overall-and-cancer-specific-survival-of-patients-with-chondrosarcoma
#19
Kehan Song, Xiao Shi, Hongli Wang, Fei Zou, Feizhou Lu, Xiaosheng Ma, Xinlei Xia, Jianyuan Jiang
BACKGROUND: Many factors have been reported to be associated with the prognosis of patients with chondrosarcoma, but clinicians have few tools to estimate precisely an individual patient's likelihood of surviving the illness. We therefore sought to develop effective nomograms to better estimate the survival of patients with chondrosarcoma. QUESTIONS/PURPOSES: (1) Which clinicopathologic features are independent prognostic factors for patients with chondrosarcoma? (2) Can we develop a nomogram to predict 3- and 5-year overall and cancer-specific survival of individual patients with chondrosarcoma based on personalized information? METHODS: We collected information on patients diagnosed with chondrosarcoma between 1988 and 2011 from the Surveillance, Epidemiology, and End Results (SEER) database...
February 21, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29469989/density-and-location-of-cd3-and-cd8-tumor-infiltrating-lymphocytes-correlate-with-prognosis-of-oral-squamous-cell-carcinoma
#20
Chen Zhou, Yaping Wu, Lei Jiang, Zhongwu Li, Pengfei Diao, Dongmiao Wang, Wei Zhang, Laikui Liu, Yanling Wang, Hongbing Jiang, Jie Cheng, Jianrong Yang
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) are regarded as adaptive immune response of the host to cancer cells and valuable prognostic factors. Here, we sought to characterize the densities and locations of CD3+ and CD8+ TILs in primary oral squamous cell carcinoma (OSCC) samples and assess their clinicopathological and prognostic significance. METHODS: A total number of 169 OSCC samples from two independent patient cohorts (Nanjing cohort, 93 cases; Wuxi cohort, 76 cases) were retrospectively collected...
February 22, 2018: Journal of Oral Pathology & Medicine
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