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Sung-Han Kim, Ho-Su Lee, Hyun-Jung Lee, Sun-Mi Kim, Sung Shin, Sang-Hyoung Park, Kyung-Jo Kim, Young-Hoon Kim, Heungsup Sung, Sang-Oh Lee, Sang-Ho Choi, Suk-Kyun Yang, Yang Soo Kim, Jun Hee Woo, Duck-Jong Han
Background/Aims: We evaluated the proposed clinical application of the combined interpretation of host factors and viral factors in two different cytomegalovirus (CMV) co-infection models. Methods: We prospectively enrolled all human immunodeficiency virus non-infected patients with confirmed Pneumocystitis jirovecii pneumonia (PCP) and those with suspected gastrointestinal CMV disease in a tertiary hospital. All patients underwent CMV interferon-γ releasing assay (IGRA) for CMV (T-track CMV, Lophius Biosciences)...
August 23, 2017: Korean Journal of Internal Medicine
Eirik O Jåstad, Turid Torheim, Kathleen M Villeneuve, Knut Kvaal, Eli Olaug Hole, Einar Sagstuen, Eirik Malinen, Cecilia M Futsaether
The amino acid l-α-alanine is the most commonly used material for solid-state Electron Paramagnetic Resonance (EPR) dosimetry, due to the formation of highly stable radicals upon irradiation, with yields proportional to the radiation dose. Two major alanine radical components designated R1 and R2 have previously been uniquely characterized from EPR and electron-nuclear double resonance (ENDOR) studies as well as from quantum chemical calculations. There is also convincing experimental evidence of a third minor radical component R3 and a tentative radical structure has been suggested, even though no well-defined spectral signature has been observed experimentally...
August 22, 2017: Journal of Physical Chemistry. A
Z X Qiu, Z S Sha, X M Che, M Y Wang
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) can effectively degrade articular cartilage matrix proteoglycan and damage the intervertebral disc of spinal tuberculosis patients, resulting in deterioration of the physical properties of articular cartilage. Transforming growth factor β activated kinase 1 (TAK1) is similar to vascular cell adhesion molecule 1 (VCAM-1) and closely related to a variety of pathophysiological processes. This study intended to explore the expression of ADAMTS-4, VCAM-1, and TAK1 in cartilage tissue obtained from spinal tuberculosis patients and their inter-relationships, aiming to provide new treatment approaches for spinal tuberculosis...
August 17, 2017: Genetics and Molecular Research: GMR
W-X Li, R-L Sha, J-Q Bao, W Luan, R-L Su, S-R Sun
OBJECTIVE: Long noncoding RNA linc-ITGB1 (linc-ITGB1) was reported to serve as a tumor promoter in breast cancer (BC). However, the clinical significance of linc-ITGB1 has not been reported. The present study aimed to determine the relationship between linc-ITGB1 expression and clinicopathological features and survival. PATIENTS AND METHODS: qRT-PCR was used to quantify the expression levels of linc-ITGB1 in BC and adjacent non-cancerous breast tissues. The X2 test was performed to determine the associations between linc-ITGB expression and the clinicopathological characters...
August 2017: European Review for Medical and Pharmacological Sciences
Y-C Guo, X-K Song, Y-F Xu, J-B Ma, J-J Zhang, P-J Han
OBJECTIVE: To analyze how changes in the levels of brain-derived neurotrophic factor (BDNF) and neuroglobin (NGB) affect learning and memory in rats with intracerebral hemorrhage. MATERIALS AND METHODS: Thirty male Sprague-Dawley rats were randomly divided into the control group, sham operation group and model group with 10 rats each. The rats in the control group were untreated, while those in the sham operation group were treated with sterile saline instead of type VII collagenase injection in the globus pallidus...
August 2017: European Review for Medical and Pharmacological Sciences
P Huang, J Wang, X Lin, F-F Yang, J-H Tan
OBJECTIVE: Body's iron metabolism is at one dynamic balance status, and abnormal iron metabolism may lead to renal anemia. Inflammation stimuli may lead to abnormal iron metabolism and aggravation of chronic failure anemia. Hepcidin can regulate iron metabolic homeostasis, further mediating renal anemia. Interleukin-10 (IL-10) is an inflammatory inhibitor, but with an unclear function in the regulation of hepcidin expression. MATERIALS AND METHODS: BALB/c mice were randomly assigned into three groups: control group; lipid polysaccharide (LPS) group, which received 0...
August 2017: European Review for Medical and Pharmacological Sciences
W Dong, M-H Chen, Y-H Yang, X Zhang, M-J Huang, X-J Yang, H-Z Wang
OBJECTIVE: To investigate the effect of dexmedetomidine on the expressions of inflammatory factors, T-lymphocyte subgroups and nuclear factor kappa-B (NF-κB) in peripheral blood monocytes in the perioperative period of radical resection of gastric cancer. PATIENTS AND METHODS: We selected 74 patients who were admitted to our hospital for radical resection of gastric cancer between January 2012 and October 2015. All patients were randomly divided into the dexmedetomidine group and the control group...
August 2017: European Review for Medical and Pharmacological Sciences
L Wei, W-Y Chen, T Hu, Y-X Tang, B-B Pan, M Jin, G-Y Kong
OBJECTIVE: Hepatic ischemia/reperfusion (I/R) injury remains to be one of the most common clinical diseases. This study aimed to explore the potential effect and mechanism of propofol in protecting rat liver from I/R injury. MATERIALS AND METHODS: The hepatic I/R model was established in Sprague-Dawley (SD) rats by perfusing the liver with heparinized cold saline through the portal vein for 20 min. The rats were then received a 100 mg/kg/d propofol administration for the continuously 10 days...
August 2017: European Review for Medical and Pharmacological Sciences
J-H Zhang, X-R Liu, C-X Sheng, Y-E Liu
OBJECTIVE: To compare the difference in the gastrointestinal hormone levels of the patients with the history of diabetes and concurrent nephropathy and investigate the clinical effect of liraglutide in the treatment of diabetic nephropathy (DN). PATIENTS AND METHODS: 42 cases of patients with DN admitted in our hospital from April 2010-May 2015 were selected and divided into phase I-II group (group A, n = 22) and phase III-IV group (group B, n = 20) according to DN phases and 20 cases of patients with diabetes rather than nephropathy admitted in our hospital during the same period were selected as the control group, all of whom underwent the routine biochemical test and gastrointestinal hormone test, the differences in gastrin (GAS), motilin (MTL) and glucagon (GLC) of DN patients were compared at different phases, the gastric emptying test was carried out on them and the gastric emptying time was recorded...
August 2017: European Review for Medical and Pharmacological Sciences
Di Wu, Molly Donovan Wong, Kai Yang, Aimin Yan, Yuhua Li, Laurie Fajardo, Bin Zheng, Xizeng Wu, Hong Liu
The ability of microbubbles to benefit the imaging quality of high-energy in-line phase contrast as compared with conventional low-energy contact mode radiography was investigated. The study was conducted by comparing in-line phase contrast imaging with conventional contact-mode projection imaging under the same dose delivered to a phantom. A custom designed phantom was employed to simulate a segment of human blood vessel injected with microbubble suspensions. The microbubbles were suspended in deionized water to obtain different volume concentrations...
August 21, 2017: IEEE Transactions on Bio-medical Engineering
Luana Cupertino Milagres, Naruna Pereira Rocha, Mariana de Santis Filgueiras, Fernanda Martins de Albuquerque, Ana Paula Pereira Castro, Milene Cristine Pessoa, Maria do Carmo Gouveia Peluzio, Juliana Farias de Novaes
OBJECTIVE: To assess the prevalence of vitamin D insufficiency and deficiency and its association with cardiometabolic risk factors, controlled by adiposity, in a representative sample of prepubescent children. DESIGN: Cross-sectional population-based study. Body composition was evaluated by dual-energy X-ray absorptiometry. Anthropometric measures and blood pressure were performed. Laboratory analyses were performed to determine the levels of vitamin D (25-hydroxyitamin D; 25(OH)D), glucose, insulin, serum lipids and intact parathyroid hormone...
August 22, 2017: Public Health Nutrition
Deguo Xing, Hongwei Gao, Zhonghao Liu, Yangyang Zhao, Mingzhi Gong
A mix of flavonoids comprising baicalin (BA) and catechin showed effective impacts on controlling the progress of knee osteoarthritis (OA). However, little is known about the underlying mechanisms. The influences of BA on the transcriptional levels of a series of proinflammatory genes were measured using real-time reverse transcription and polymerase chain reaction (RT-PCR). The expressions of proteins involved in nuclear factor-κB (NF-κB) activation were detected by Western blot. The in vitro results were confirmed in a mouse OA model...
August 22, 2017: Journal of Interferon & Cytokine Research
Samantha A Reina, Maria M Llabre, Denise C Vidot, Carmen R Isasi, Krista Perreira, Mercedes Carnethon, Christina M Parrinello, Linda C Gallo, Guadalupe X Ayala, Alan Delamater
BACKGROUND: Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, is being diagnosed in youth. Specific diagnostic criteria used to define MetS influence prevalence estimates and populations considered at risk for cardiovascular disease. The National Cholesterol Education Program's Adult Treatment Panel III (ATP), the World Health Organization (WHO), and the International Diabetes Federation (IDF) provide three MetS definitions used in medical research. This study examined concordance among these definitions in 1137 children 10-16 years of age, who participated in the Hispanic Community Children's Health Study/Study of Latino Youth...
August 22, 2017: Metabolic Syndrome and related Disorders
Lisa Allen, Alison Buckner, Carly A Buckner, Pablo Cano, Robert M Lafrenie
BACKGROUND: Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae), known as Cat's Claw or Uña de gato, is a traditionally used medicinal plant native to Peru. Some studies have shown that U. tomentosa can act as an antiapoptotic agent and enhance DNA repair in chemotherapy-treated cells although others have shown that U. tomentosa enhanced apoptosis. OBJECTIVE: To determine if treatment with U. tomentosa can significantly enhance cell death in THP-1 cells exposed to ionizing radiation...
July 2017: Pharmacognosy Research
Wenjuan Liao, Hongbing Liu, Yiwei Zhang, Ji Hoon Jung, Jiaxiang Chen, Xiaohua Su, Yeong C Kim, Elsa R Flores, San Ming Wang, Malwina Czarny-Ratajczak, Wen Li, Shelya X Zeng, Hua Lu
TAp63, a member of the p53 family, has been shown to regulate energy metabolism. Here, we report coiled coil domain-containing 3 (CCDC3) as a new TAp63 target. TAp63, but not ΔNp63, p53 or p73, upregulates CCDC3 expression by directly binding to its enhancer region. The CCDC3 expression is markedly reduced in TAp63-null mouse embryonic fibroblasts and brown adipose tissues and by tumor necrosis factor alpha that reduces p63 transcriptional activity, but induced by metformin, an anti-diabetic drug that activates p63...
August 21, 2017: Scientific Reports
Andrew Hettle, Alexander Fillo, Kento Abe, Patricia Massel, Benjamin Pluvinage, David N Langelaan, Steven P Smith, Alisdair B Boraston
BH0236 from Bacillus halodurans is a multimodular β-1,3-glucanase comprising an N-terminal family 81 glycoside hydrolase catalytic module, an internal family 6 carbohydrate-binding module (CBM) that binds the nonreducing end of β-1,3-glucans chains, and an uncharacterized C-terminal module classified into CBM family 56. Here, we determined that this latter CBM, BhCBM56, bound the soluble β-1,3-glucan laminarin with a dissociation constant (Kd) of ~26 μM, displayed higher affinity for insoluble β-1,3-glucans with Kds of ~2-10 μM, but lacked affinity for β-1,3-glucooligosaccharides...
August 21, 2017: Journal of Biological Chemistry
X L Zhao, L Li, M Niinomi, M Nakai, D L Zhang, C Suryanarayana
Good ductility, low magnetic susceptibility, and tunable Young's modulus are highly desirable properties for materials usage as spinal fixation rods. In this study, the effects of niobium content on the microstructure, magnetic susceptibility, and mechanical properties of Zr-xNb (13≤x≤23 wt.%) alloys were investigated. For the Zr-15Nb and Zr-17Nb alloys, a remarkable increase in Young's modulus was achieved due to the occurrence of deformation-induced ω phase transformation. This was the result of the competition of two factors associated with the Nb content: an increase of the stability of β phase and a decrease of the amount of athermal ω phase with increasing Nb content...
August 18, 2017: Acta Biomaterialia
Trace Hobbs, Logan N Schultz, Ellen G Lauchnor, Robin Gerlach, Dirk Lange
PURPOSE: Infection stones comprise approximately 15% of all urinary tract stones and are induced by infection with urease-positive pathogens. The bacteria within the stone matrix present significant treatment impediments compared to metabolic kidney stones. While much is known about how urinary composition regulates metabolic stone formation, there is a general lack of knowledge around which urinary factors regulate the rate of infection stone formation. Unfortunately, more in-depth research into infection stones is limited by the lack of suitable models for the real-time study of bacterial biofilm formation and stone formation under varying conditions...
August 18, 2017: Journal of Urology
Atsuya Yamashita, Mayumi Tamaki, Hirotake Kasai, Tomohisa Tanaka, Teruhime Otoguro, Akihide Ryo, Shinya Maekawa, Nobuyuki Enomoto, Nicole J de Voogd, Junichi Tanaka, Kohji Moriishi
The currently available antiviral agents for chronic infection with hepatitis B virus (HBV) are pegylated interferon-α and nucleoside/nucleotide analogues, although it has been difficult to completely eliminate covalently closed circular DNA (cccDNA) from patients. To identify an antiviral compound targeting HBV core promoter, 15 terpenes originating from marine organisms were screened using a cell line expressing firefly luciferase under the control of the HBV core promoter. Metachromin A, which is a merosesquiterpene isolated from the marine sponge Dactylospongia metachromia, inhibited the viral promoter activity at the highest level among the tested compounds, and suppressed HBV production with an EC50 value of 0...
August 4, 2017: Antiviral Research
Nora M Haney, Hoang M T Nguyen, Matthew Honda, Asim B Abdel-Mageed, Wayne J G Hellstrom
INTRODUCTION: It is common for men to develop erectile dysfunction after radical prostatectomy. The anatomy of the rat allows the cavernous nerve (CN) to be identified, dissected, and injured in a controlled fashion. Therefore, bilateral CN injury (BCNI) in the rat model is routinely used to study post-prostatectomy erectile dysfunction. AIM: To compare and contrast the available literature on pharmacologic intervention after BCNI in the rat. METHODS: A literature search was performed on PubMed for cavernous nerve and injury and erectile dysfunction and rat...
August 18, 2017: Sexual Medicine Reviews
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