keyword
https://read.qxmd.com/read/38657159/dual-energy-computed-tomography-virtual-noncalcium-imaging-of-intracranial-arteries-in-acute-ischemic-stroke-differentiation-between-acute-thrombus-and-calcification
#1
JOURNAL ARTICLE
Yuki Shinohara, Tomomi Ohmura, Fumiaki Sasaki, Yuichiro Sato, Takato Inomata, Toshihide Itoh, Toshibumi Kinoshita
OBJECTIVE: Hyperdense artery sign (HAS) on noncontrast brain computed tomography (CT) indicates an acute thrombus within the cerebral artery. It is a valuable imaging biomarker for diagnosing large-vessel occlusion; however, its identification may be challenging with the presence of vascular calcification. Dual-energy CT virtual noncalcium (VNCa) imaging using a 3-material decomposition algorithm is helpful for differentiating between calcification and hemorrhage. This study aimed to clarify the potential of VNCa imaging for differentiating HAS from vascular calcification...
April 24, 2024: Journal of Computer Assisted Tomography
https://read.qxmd.com/read/38657155/predicting-microwave-ablation-early-efficacy-in-pulmonary-malignancies-via-%C3%AE-radiomics-models
#2
JOURNAL ARTICLE
Jing Yang, Chen Yang, Jianju Feng, Fandong Zhu, Zhenhua Zhao
OBJECTIVE: This study aimed to explore the value of preoperative and postoperative computed tomography (CT)-based radiomic signatures and Δ radiomic signatures for evaluating the early efficacy of microwave ablation (MWA) for pulmonary malignancies. METHODS: In total, 115 patients with pulmonary malignancies who underwent MWA treatment were categorized into response and nonresponse groups according to relevant guidelines and consensus. Quantitative image features of the largest pulmonary malignancies were extracted from CT noncontrast scan images preoperatively (time point 0, TP0) and immediately postoperatively (time point 1, TP1)...
April 24, 2024: Journal of Computer Assisted Tomography
https://read.qxmd.com/read/38657145/-frequency-of-spinopelvic-alterations-in-postoperative-total-hip-arthroplasty-patients-and-their-association-with-functional-outcomes
#3
JOURNAL ARTICLE
C A Valdivia-Zúñiga, G Bobadilla-Lescano, F A Martínez-Escalante, A J Balam-May, F Cámara-Arrigunaga
INTRODUCTION: the analysis of spinopelvic imbalance in patients undergoing total hip arthroplasty has gained significance in recent years, being recognized as a risk factor for instability. Few reports exist regarding the prevalence of spinopelvic alterations in Latin American literature. The aim of this study is to determine the frequency of spinopelvic imbalance in our patients and to associate them with functional outcomes. MATERIAL AND METHODS: 29 patients who underwent total hip arthroplasty using a lateral approach (32 arthroplasties) were included...
2024: Acta Ortopédica Mexicana
https://read.qxmd.com/read/38657099/comprehensive-genetic-profiling-reveals-frequent-alterations-of-driver-genes-on-the-x-chromosome-in-extranodal-nk-t-cell-lymphoma
#4
JOURNAL ARTICLE
Yuta Ito, Amira Marouf, Yasunori Kogure, Junji Koya, Raphaël Liévin, Julie Bruneau, Mariko Tabata, Yuki Saito, Sumito Shingaki, Mitsuhiro Yuasa, Kentaro Yamaguchi, Koichi Murakami, Robert Weil, Manon Vavasseur, Guillaume P Andrieu, Mehdi Latiri, Layla Veleanu, Michaël Dussiot, Isabelle André, Akshay Joshi, Chantal Lagresle-Peyrou, Aude Magerus, Sammara Chaubard, David Lavergne, Emmanuel Bachy, Erika Brunet, Virginie Fataccioli, Chantal Brouzes, Camille Laurent, Laurence De Leval, Alexandra Traverse-Glehen, Céline Bossard, Marie-Cécile Parrens, Véronique Meignin, Laure Philippe, Julien Rossignol, Felipe Suarez, Jean-Marie Michot, Olivier Tournilhac, Gandhi Damaj, François Lemonnier, Christine Bôle-Feysot, Patrick Nitschké, Bruno Tesson, Cécile Laurent, Thierry Molina, Vahid Asnafi, Yosaku Watatani, Kenichi Chiba, Ai Okada, Yuichi Shiraishi, Sachiko Tsukita, Koji Izutsu, Hiroaki Miyoshi, Koichi Ohshima, Seiji Sakata, Akito Dobashi, Kengo Takeuchi, Masashi Sanada, Philippe Gaulard, Arnaud Jaccard, Seishi Ogawa, Olivier Hermine, Keisuke Kataoka, Lucile Couronné
Extranodal NK/T-cell lymphoma (ENKTCL) is an Epstein-Barr virus (EBV)-related neoplasm with male dominance and a poor prognosis. A better understanding of the genetic alterations and their functional roles in ENKTCL could help improve patient stratification and treatments. Here, we performed comprehensive genetic analysis of 177 ENKTCL cases to delineate the landscape of mutations, copy number alterations (CNAs), and structural variations, identifying 34 driver genes including six previously unappreciated ones, namely HLA-B, HLA-C, ROBO1, CD58, POT1, and MAP2K1...
April 24, 2024: Cancer Research
https://read.qxmd.com/read/38656651/a-novel-t-x-21-p11-4-q22-12-translocation-adds-to-the-role-of-bcor-and-runx1-in-myelodysplastic-syndromes-and-acute-myeloid-leukemias
#5
JOURNAL ARTICLE
Elena Mavridou, Anair Graciela Lema Fernandez, Carlotta Nardelli, Valentina Pierini, Martina Quintini, Silvia Arniani, Danika Di Giacomo, Barbara Crescenzi, Caterina Matteucci, Constantina Sambani, Cristina Mecucci
In myeloid neoplasms, both fusion genes and gene mutations are well-established events identifying clinicopathological entities. In this study, we present a thus far undescribed t(X;21)(p11.4;q22.12) in five cases with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The translocation was isolated or accompanied by additional changes. It did not generate any fusion gene or gene deregulation by aberrant juxtaposition with regulatory sequences. Molecular analysis by targeted next-generation sequencing showed that the translocation was accompanied by at least one somatic mutation in TET2, EZH2, RUNX1, ASXL1, SRSF2, ZRSR2, DNMT3A, and NRAS genes...
April 2024: Genes, Chromosomes & Cancer
https://read.qxmd.com/read/38656471/risk-factors-contributing-to-tick-acaricide-control-failure-in-communal-areas-of-the-oliver-tambo-district-eastern-cape-province-south-africa
#6
JOURNAL ARTICLE
William Diymba Dzemo, Oriel Thekisoe, Patrick Vudriko
Application of chemical acaricides in the control of ticks has led to the problem of tick-acaricide control failure. To obtain an understanding of the possible risk factors involved in this tick-acaricide control failure, this study investigated tick control practices on communal farms in the north-eastern part of the Eastern Cape Province (ECP) of South Africa. A semi-structured questionnaire designed to document specific farm attributes and acaricide usage practices was administered at 94 communal farms from the Oliver Tambo District municipality of the ECP...
April 24, 2024: Experimental & Applied Acarology
https://read.qxmd.com/read/38656451/racial-disparities-in-patterns-and-modes-of-current-and-daily-marijuana-use-among-adults-living-with-children
#7
JOURNAL ARTICLE
Hongying Daisy Dai, Regina Idoate, Avina Mahroke, Chad Abresch
OBJECTIVE: This study sought to examine racial disparities in marijuana use among U.S. adults living with children. METHODS: Data are drawn from the 2022 Behavioral Risk Factor Surveillance System to examine the prevalence of current (past month) and frequent (≥20 days in the last 30 days) marijuana use along with the mode of marijuana use by 7 racial and ethnic groups (non-Hispanic [NH] White, NH-Black, Hispanic, NH American Indian or Alaskan Native [AI/AN], NH-Asian, NH Native Hawaiian or other Pacific Islander only [NH/PI], and other/multiple races, n=22,659)...
April 24, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38656350/fostering-effective-and-sustainable-scientific-collaboration-and-knowledge-exchange-a-workshop-based-approach-to-establish-a-national-ecological-observatory-network-neon-domain-specific-user-group
#8
JOURNAL ARTICLE
Alison Donnelly, Ankur R Desai, Katherine A Heckman, Lucas E Nave, Michael J Cramer, Marie Faust, Peter Weishampel, Caleb Slemmons, Christian G Andresen, Edward Ayres, Stacy R Cotey, Kathryn M Docherty, Joshua Hatzis, Kathryn Hofmeister, Jalene M LaMontagne, John Lenters, Noah R Lottig, Amy M Marcarelli, Jessica Miesel, Jason Riddle, Meghan Salmon-Tumas, Mike D SanClements, Subash Sapkota, Mark D Schwartz, Puja Sharma, Ojaswee Shrestha, Geoffrey Vincent, Angela Waupochick, Ting Zheng, Ye Zhiwei
The decision to establish a network of researchers centers on identifying shared research goals. Ecologically specific regions, such as the USA's National Ecological Observatory Network's (NEON's) eco-climatic domains, are ideal locations by which to assemble researchers with a diverse range of expertise but focused on the same set of ecological challenges. The recently established Great Lakes User Group (GLUG) is NEON's first domain specific ensemble of researchers, whose goal is to address scientific and technical issues specific to the Great Lakes Domain 5 (D05) by using NEON data to enable advancement of ecosystem science...
April 24, 2024: International Journal of Biometeorology
https://read.qxmd.com/read/38656092/how-to-standardize-the-diagnostic-approach-to-pituitary-neuroendocrine-tumors
#9
JOURNAL ARTICLE
Sofia Asioli, Federica Guaraldi, Matteo Zoli, Diego Mazzatenta, Chiara Villa
Pituitary tumors present heterogeneous biochemical, clinico-radiological, and histological features. Although histologically benign, a non-negligible number of cases present an unpredictable aggressive behavior with local invasiveness, partial/complete resistance to treatment and/or recurrence after surgery, and, rarely, metastasize, overall leading to a significant increase of morbidity, and, thus, requiring skilled multidisciplinary management in referral Centers. Histopathological diagnosis is essential to stratify cancer patient risk and uniform follow-up among Centers...
April 24, 2024: Minerva endocrinology
https://read.qxmd.com/read/38655829/-diffuse-cystic-lung-disease
#10
REVIEW
Silviu Mihail Chirila
Diffuse cystic lung disease (DCLD) represents a heterogeneous group of conditions, typically characterized by the presence of multiple thin-walled, predominantly round parenchymal lucencies. The increased accessibility of computed tomography (CT) underscores the growing relevance of a relatively rare group of diseases as more clinicians are confronted with the presence of multiple lung cysts on the chest CT scan. Although the etiology of these conditions is very diverse, the focus of the differential diagnosis revolves around four primary causative factors - Lymphangioleiomyomatosis (LAM), Pulmonary Langerhanscell histiocytosis (PLCH), Birt-Hogg-Dubé (BHD) and lymphoid interstitial pneumonia (LIP)...
February 2024: Therapeutische Umschau. Revue Thérapeutique
https://read.qxmd.com/read/38655744/environmental-risk-factors-analysis-in-paediatric-oral-health-a-cross-sectional-study
#11
JOURNAL ARTICLE
G Franciosi, S Fornich, C Di Matteo, G Malvicini, C Marruganti, S Grandini, C Gaeta
AIM: The aim of the present study was to evaluate the association between environmental risk factors [adherence to the Mediterranean diet (MD), eating habits, hygiene habits, body mass index (BMI)] with the presence of caries in a university-based cohort of paediatric patients. MATERIALS: A total of 118 paediatric patients were included in the study. In addition to the evaluation of clinical (vitality test, percussion test) and radiographic (X-ray bitewing, OPT) parameters, patients' lifestyle was investigated through validated questionnaries...
April 1, 2024: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://read.qxmd.com/read/38655533/a-systematic-review-on-the-prospects-of-x-and-y-sexed-semen-in-ruminant-livestock-implications-for-conservation-a-south-african-perspective
#12
Jabulani Nkululeko Ngcobo, Tshimangadzo Lucky Nedambale, Sindisiwe Mbali Sithole, Bohani Mtileni, Takalani Judas Mpofu, Fhulufhelo Vincent Ramukhithi, Tlou Caswel Chokoe, Khathutshelo Agree Nephawe
South Africa is home to numerous indigenous and locally developed sheep (Nguni Pedi, Zulu, and Namaqua Afrikaner, Afrino, Africander, Bezuidenhout Africander, Damara, Dorper, Döhne Merino, Meat Master, South African Merino, South African Mutton Merino, Van Rooy, and Dorper), goat (SA veld, Tankwa, Imbuzi, Bantu, Boer, and Savanna) and cattle (Afrigus, Afrikaner, Bolowana, Bonsmara, Bovelder, Drakensberger, South African Angus, South African Dairy Swiss, South African Friesland, South African Red, and Veld Master) animals...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38655461/regulating-oxygen-vacancies-by-zn-atom-doping-to-anchor-and-disperse-promoter-ba-on-mgo-support-to-improve-ru-based-catalysts-activity-for-ammonia-synthesis
#13
JOURNAL ARTICLE
Yuanjie Chen, Junqiao He, Haiyan Lei, Qunyao Tu, Chen Huang, Xiangwei Cheng, Xiazhen Yang, Huazhang Liu, Chao Huo
In heterogeneous catalysis, surface defects are widely regarded as an effective means to enhance the catalytic performance of catalysts. In this study, the oxygen vacancy-rich Mg(1- X ) Zn X O solid solution support was successfully prepared by doping a small amount of Zn into MgO nanocrystals. Based on this support, Ru/Ba-Mg(1- X ) Zn X O catalyst for ammonia synthesis was prepared. Characterization using TEM, EPR, XPS, and DFT calculations confirmed the successful substitution of Zn atoms for Mg atoms leading to the formation of more oxygen vacancies (OVs)...
April 22, 2024: RSC Advances
https://read.qxmd.com/read/38655457/the-impact-of-social-environmental-factors-on-iq-in-syndromic-intellectual-developmental-disabilities
#14
REVIEW
Walker S McKinney, Desireé N Williford, Leonard Abbeduto, Lauren M Schmitt
Despite having the same underlying genetic etiology, individuals with the same syndromic form of intellectual developmental disability (IDD) show a large degree of interindividual differences in cognition and IQ. Research indicates that up to 80% of the variation in IQ scores among individuals with syndromic IDDs is attributable to nongenetic effects, including social-environmental factors. In this narrative review, we summarize evidence of the influence that factors related to economic stability (focused on due to its prevalence in existing literature) have on IQ in individuals with syndromic IDDs...
2024: Journal of Clinical and Translational Science
https://read.qxmd.com/read/38655015/dual-energy-x-ray-absorptiometry-derived-knee-shape-may-provide-a-useful-imaging-biomarker-for-predicting-total-knee-replacement-findings-from-a-study-of-37-843-people-in-uk-biobank
#15
JOURNAL ARTICLE
Rhona A Beynon, Fiona R Saunders, Raja Ebsim, Monika Frysz, Benjamin G Faber, Jennifer S Gregory, Claudia Lindner, Aliya Sarmanova, Richard M Aspden, Nicholas C Harvey, Timothy Cootes, Jonathan H Tobias
OBJECTIVE: We aimed to create an imaging biomarker for knee shape using knee dual-energy x-ray absorptiometry (DXA) scans and investigate its potential association with subsequent total knee replacement (TKR), independently of radiographic features of knee osteoarthritis and established risk factors. METHODS: Using a 129-point statistical shape model, knee shape (expressed as a B-score) and minimum joint space width (mJSW) of the medial joint compartment (binarized as above or below the first quartile) were derived...
June 2024: Osteoarthritis and cartilage open
https://read.qxmd.com/read/38654930/association-between-metabolic-syndrome-severity-score-and-cardiovascular-disease-results-from-a-longitudinal-cohort-study-on-chinese-adults
#16
JOURNAL ARTICLE
Jing-Jing Lin, Pin-Yuan Dai, Jie Zhang, Yun-Qi Guan, Wei-Wei Gong, Min Yu, Le Fang, Ru-Ying Hu, Qing-Fang He, Na Li, Li-Xin Wang, Ming-Bin Liang, Jie-Ming Zhong
OBJECTIVE: This study aimed to quantify the severity of metabolic syndrome(MetS) and investigate its association with cardiovascular disease(CVD) risk on Chinese adults. METHODS: 13,500 participants from the Zhejiang Adult Chronic Disease Study were followed up between 2010 and 2021. A continuous MetS severity score derived from the five components of MetS was used to quantify MetS severity, and the association between MetS severity and the risk of incident CVD was assessed using Cox proportional hazard and restricted cubic spline regression...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38654817/cardiovascular-calcification-in-hemodialysis-patients-a-qatar-based-prevalence-and-risk-factors-study
#17
JOURNAL ARTICLE
Tarek Ghonimi, Abdullah Hamad, Tarek Fouda, Fadwa AlAli, Mohamad Ezzat, Mohamed Awad, Rania Ibrahim, Mohamed Amin, Mohamad Alkadi, Hassan Ali Al-Malki
BACKGROUND: Patients with end-stage kidney disease on hemodialysis (HD) have an increased risk of death due to the high prevalence of cardiovascular disease. Vascular calcification (VC) is predictive of cardiovascular disease and mortality. We conducted a study to evaluate the prevalence and risk factors for VC in dialysis patients in Qatar. METHODS: This is a retrospective nationwide study including all chronic ambulatory dialysis patients in Qatar from 2020 to 2022...
2024: Qatar Medical Journal
https://read.qxmd.com/read/38654691/pxr-activation-relieves-deoxynivalenol-induced-liver-oxidative-stress-via-malat1-lncrna-m-6-a-demethylation
#18
JOURNAL ARTICLE
Yue Feng, Jiakun Shen, Zishen Lin, Zeyi Chen, Min Zhou, Xi Ma
Deoxynivalenol (DON) is a prevalent toxin causing severe liver damage through hepatocellular oxidative stress. However, the underlying mechanisms and effective therapeutic approaches remain unknown. Here, the unique role of the xenobiotic metabolism factor pregnane X receptor (PXR) in mediating DON-induced hepatocellular oxidative stress is investigated. Treatment with the PXR agonist 3-indole-propionic acid (IPA) alleviates DON-induced oxidative stress and liver injury both in vitro and in vivo. Mechanistically, it is discovered for the first time that PXR agonist IPA directly transactivates the m6 A demethylase FTO expression, leading to site-specific demethylation and decreased abundance of YTHDC1-bound Malat1 lncRNA at single-nucleotide resolution...
April 24, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38654384/determinants-of-puerperal-sepsis-among-postpartum-women-at-a-tertiary-care-hospital-in-ethiopia-an-unmatched-case-control-study
#19
JOURNAL ARTICLE
Keraj Seboka, Abenet Menene Gurara, Nardos Tilahun Bekele, Yohanes Abera Belachwe, Mihiret Shawel Getahun, Yohannes Mekuria Negussie
BACKGROUND: Puerperal sepsis, is a significant factor in maternal morbidity and mortality, especially in regions with lower income levels where maternal mortality rates are highest. However, it can be largely avoided if detected in time. Recognizing and dealing with the root causes early is essential in addressing this problem. Therefore, this study aimed to identify the determinants of puerperal sepsis among postpartum women at a tertiary care hospital in Ethiopia. METHODS: An institutional-based unmatched case-control study was conducted among 266 postpartum women (88 cases and 178 controls) from October 1, 2023 to November 30, 2023...
April 24, 2024: Contraception and Reproductive Medicine
https://read.qxmd.com/read/38654371/severity-of-covid-19-infection-in-patients-with-covid-19-combined-with-diabetes
#20
JOURNAL ARTICLE
Dan Lu, Yuhong Liu, Pengcheng Ma, Rui Hou, Jin Wang
PURPOSE: This study aimed to analyse the correlation between blood glucose control and the severity of COVID-19 infection in patients with diabetes. METHODS: Clinical and imaging data of a total of 146 patients with diabetes combined with COVID-19 who visited our hospital between December 2022 and January 2023 were retrospectively collected. The patients were divided into the 'good blood glucose control' group and the 'poor blood glucose control' group based on an assessment of their blood glucose control...
April 23, 2024: Journal of Health, Population, and Nutrition
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