YuWei Zhou, Chen Chen, YuPin Chen, YuXuan Ding, ShengLong Li, JiaXin Wu, ShiRan Hong, BingZheng Lu, HuaFeng Liang, Ying Liu, Ying Ouyang, Wei Yin, Cheng Hu
Acute lung injury (ALI) is a severe and potentially fatal respiratory condition with limited treatment options. The pathological evolution of ALI is driven by persistent inflammation, destruction of the pulmonary vascular barrier and oxidative stress. Evidence from prior investigations has identified 5α-androst-3β,5α,6β-Triol (TRIOL), a synthetic analogue of the naturally occurring neuroprotective compound cholestane-3β,5α,6β-triol, possesses notable anti-inflammatory and antioxidative properties...
February 6, 2024: International Immunopharmacology