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stress induced pulmonary edema

Yuan Zong, Huali Zhang
Sepsis is a serious medical problem and is one of the main causes of high mortality in intensive care units. Fifty percent of patients with severe sepsis will develop acute lung injury (ALI). Amentoflavone (AMF) is a polyphenolic compound possessing potent anti-inflammatory activities. The study aimed to explore the protective effects of AMF against ALI in cecal ligation and puncture (CLP)-induced septic rats. The results showed that AMF administration protected against septic ALI, as reflected by marked amelioration of histological injury of lung tissues and decrease of pulmonary edema in CLP-treated rats...
October 8, 2016: Acta Biochimica Polonica
Alexandra Mani, Chryssoula Staikou, Iosifina Karmaniolou, Nikolaos Orfanos, Anastassios Mylonas, Tzortzis Nomikos, Agathi Pafiti, Apostolos Papalois, Nikolaos Arkadopoulos, Vassilios Smyrniotis, Kassiani Theodoraki
AIM OF THE STUDY: To investigate the pulmonary oxidative stress and possible protective effect of N-Acetylcysteine (NAC) and Desferoxamine (DFX)in a porcine model subjected to hemorrhagic shock. MATERIALS AND METHODS: Twenty-one pigs were randomly allocated to Group-A (sham, n = 5), Group-B (fluid resuscitation, n = 8) and Group-C (fluid, NAC and DFX resuscitation, n = 8). Groups B and C were subjected to a 40-min shock period induced by liver trauma, followed by a 60-min resuscitation period...
August 15, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Kunal Karamchandani, Brandon Bortz, Sonia Vaida
BACKGROUND Acute pulmonary edema in a pregnant patient is associated with significant morbidity and mortality. Takotsubo syndrome, or stress-induced cardiomyopathy, is a rare cause of acute pulmonary edema in a pregnant patient, especially prior to delivery of the fetus. CASE REPORT We describe a case of a pregnant patient who presented with acute pulmonary edema and eclampsia and was found to have Takotsubo syndrome. To the best of our knowledge, eclampsia as a precipitating factor for Takotsubo syndrome has not been described in literature...
September 23, 2016: American Journal of Case Reports
Wu Jiang, Maoqiang Li, Fan He, Wangxiang Yao, Zhenyu Bian, Xuepeng Wang, Liulong Zhu
The biological effects of asiatic acid (AA) on spinal cord injury (SCI)-induced acute lung injury (ALI) have not been investigated. We aimed to investigate the therapeutic efficacy and molecular mechanisms of AA on SCI-induced ALI. One-hundred and fifty Sprague-Dawley rats were randomly assigned to five groups: sham, SCI, SCI + dexamethasone (Dex, 2 mg/kg), SCI + AA (30 mg/kg), and SCI + AA (75 mg/kg). The influences of AA on histologic changes, pulmonary edema, neutrophil infiltration and activation, proinflammatory cytokine production, oxidative stress, and Nrf2 and NLRP3 inflammasome protein expression were estimated...
September 7, 2016: Inflammation
Mariana T Farcas, Elena R Kisin, Autumn L Menas, Dmitriy W Gutkin, Alexander Star, Richard S Reiner, Naveena Yanamala, Kai Savolainen, Anna A Shvedova
Over the past several years there has been an increased number of applications of cellulosic materials in many sectors, including the food industry, cosmetics, and pharmaceuticals. However, to date, there are few studies investigating the potential adverse effects of cellulose nanocrystals (CNC). The objective of this study was to determine long-term outcomes on the male reproductive system of mice upon repeated pharyngeal aspiration exposure to CNC. To achieve this, cauda epididymal sperm samples were analyzed for sperm concentration, motility, morphological abnormalities, and DNA damage...
2016: Journal of Toxicology and Environmental Health. Part A
Alfred A Bove
Although the lungs are a critical component of exercise performance, their response to exercise and other environmental stresses is often overlooked when evaluating pulmonary performance during high workloads. Exercise can produce capillary leakage, particularly when left atrial pressure increases related to left ventricular (LV) systolic or diastolic failure. Diastolic LV dysfunction that results in elevated left atrial pressure during exercise is particularly likely to result in pulmonary edema and capillary hemorrhage...
April 2016: Methodist DeBakey Cardiovascular Journal
Thangapandiyan Shanmugam, Miltonprabu Selvaraj, Senthilraja Poomalai
BACKGROUND: Since this Nrf2-dependent cellular defense response is able to protect multi-organs, including cancer, neurodegenerative diseases, cardiovascular diseases, inflammation and chronic lung injury. The antioxidant and anti-inflammatory potential of Epigallocatechin gallate (EGCG) and Nrf2/Keap1 signaling mechanisms in pulmonary toxicity have not been clarified. In the present study, we demonstrated that protective efficacy of EGCG against fluoride (Fl) induced oxidative stress mediated lung injury in rats...
October 2016: International Immunopharmacology
Lu Yang, Xufeng Chen, Samantha M Simet, Guoku Hu, Yu Cai, Fang Niu, Yeonhee Kook, Shilpa J Buch
Abuse of psychostimulants such as cocaine has been shown to be closely associated with complications of the lung such as pulmonary hypertension, edema, increased inflammation and infection. However, the mechanism by which cocaine mediates impairment of alveolar epithelial barrier integrity that underlies various pulmonary complications isn't well determined. Herein we sought to investigate the role of cocaine in disrupting the alveolar epithelial barrier function and the associated signaling cascade. Using the combinatorial ECIS and FITC-dextran permeability assays, we demonstrated cocaine-mediated disruption of the alveolar epithelial barrier as evidenced by increased epithelial monolayer permeability with a concomitant loss of tight junction protein Zo-1 in both mouse primary alveolar epithelial cells and the alveolar epithelial cell line - L2 cells...
July 8, 2016: American Journal of Respiratory Cell and Molecular Biology
Carl Edmonds
The evolution of scuba divers pulmonary edema is described. When discovered in 1981, it was believed to be a cold-induced response in a submerged, otherwise healthy, scuba diver. The clinical features are described and discussed, as are the demographics. An alleged prevalence of 1.1% was complicated by problematic statistics and an apparent increase in reported cases. Recurrences both while diving and swimming or snorkeling were common. More recent case reports and surveys are described, identifying predisposing factors and associations, including cardiac pathology...
March 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Jinyan Yu, Zhongsen Ma, Sreerama Shetty, Mengshi Ma, Jian Fu
Lung endothelial damage contributes to the pathogenesis of acute lung injury. New strategies against lung endothelial barrier dysfunction may provide therapeutic benefits against lung vascular injury. Cell-cell junctions and microtubule cytoskeleton are basic components in maintaining endothelial barrier integrity. HDAC6, a deacetylase primarily localized in the cytoplasm, has been reported to modulate nonnuclear protein function through deacetylation. Both α-tubulin and β-catenin are substrates for HDAC6...
July 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
Diego F Alvarez, Nicole Housley, Anna Koloteva, Chun Zhou, Kristen O'Donnell, Jonathon P Audia
RATIONALE: Dysregulated activation of the Inflammasome-Caspase-1-Interleukin-1β axis elicits damaging hyper-inflammation during critical illnesses such as pneumonia and sepsis. However, in critical illness models of Salmonella infection, burn, or shock, Caspase-1 inhibition worsens outcomes. These paradoxical effects suggest that Caspase-1 drives novel protective responses. Whether the protective effects of Caspase-1 activation involve canonical immune cell and/or non-immune cell responses is unknown...
April 27, 2016: American Journal of Respiratory Cell and Molecular Biology
Elena Lopez-Rodriguez, Caroline Boden, Mercedes Echaide, Jesus Perez-Gil, Martin Kolb, Jack Gauldie, Ulrich A Maus, Matthias Ochs, Lars Knudsen
Transforming growth factor-β1 (TGF-β1) is involved in regulation of cellular proliferation, differentiation, and fibrogenesis, inducing myofibroblast migration and increasing extracellular matrix synthesis. Here, TGF-β1 effects on pulmonary structure and function were analyzed. Adenovirus-mediated gene transfer of TGF-β1 in mice lungs was performed and evaluated by design-based stereology, invasive pulmonary function testing, and detailed analyses of the surfactant system 1 and 2 wk after gene transfer...
June 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
Jutaro Fukumoto, Ruan Cox, Itsuko Fukumoto, Young Cho, Prasanna Tamarapu Parthasarathy, Lakshmi Galam, Richard F Lockey, Narasaiah Kolliputi
Apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPK kinase kinase kinase (MAP3K) family, is activated by various stimuli, which include oxidative stress, endoplasmic reticulum (ER) stress, calcium influx, DNA damage-inducing agents and receptor-mediated signaling through tumor necrosis factor receptor (TNFR). Inspiration of a high concentration of oxygen is a palliative therapy which counteracts hypoxemia caused by acute lung injury (ALI)-induced pulmonary edema. However, animal experiments so far have shown that hyperoxia itself could exacerbate ALI through reactive oxygen species (ROS)...
2016: PloS One
Caroline Scally, Trevor Ahearn, Amelia Rudd, Christopher J Neil, Janaki Srivanasan, Baljit Jagpal, John Horowitz, Michael Frenneaux, Dana K Dawson
Acute stress-induced (Tako-tsubo) cardiomyopathy is an increasingly recognized but insufficiently characterized syndrome. Here, we investigate the pathophysiology of right ventricular (RV) involvement in Tako-tsubo and its recovery time course. We prospectively recruited 31 patients with Tako-tsubo with predominantly ST-elevation electrocardiogram and 18 controls of similar gender, age, and co-morbidity distribution. Patients underwent echocardiography and cardiac magnetic resonance (CMR) imaging on a 3T Philips scanner in the acute phase (day 0 to 3 after presentation) and at 4-months follow-up...
March 1, 2016: American Journal of Cardiology
Shasha Tao, Montserrat Rojo de la Vega, Hector Quijada, Georg T Wondrak, Ting Wang, Joe G N Garcia, Donna D Zhang
Mechanical ventilation (MV) is a therapeutic intervention widely used in the clinic to assist patients that have difficulty breathing due to lung edema, trauma, or general anesthesia. However, MV causes ventilator-induced lung injury (VILI), a condition characterized by increased permeability of the alveolar-capillary barrier that results in edema, hemorrhage, and neutrophil infiltration, leading to exacerbated lung inflammation and oxidative stress. This study explored the feasibility of using bixin, a canonical NRF2 inducer identified during the current study, to ameliorate lung damage in a murine VILI model...
2016: Scientific Reports
Yule Kou, Panpan Zhang, Hongyang Wang, Jiabin Zhang, Xiaoqing Han, Jiangtao Yu, Ling Wang, Min Zhang
OBJECTIVE: To observe the changes of angiotensin II and the levels of oxidation stress during the development of chronic intermittent hypoxia(CIH)-induced pulmonary injury in rats, and the effect in the mechanism of CIH-induced pulmonary injury. METHODS: Seventy-two male Wistar rats were divided into three groups: control group (UC), sham control group (SC) and chronic intermittent hypoxia group (CIH). The three groups were also divided into 1 w, 2 w, 3 w, 4 w time subgroups, and each time subgroup has 6 rats...
August 2015: Chinese Journal of Tuberculosis and Respiratory Diseases
Kun-Cheng Li, Yu-Ling Ho, Cing-Yu Chen, Wen-Tsong Hsieh, Yuan-Shiun Chang, Guan-Jhong Huang
Acute lung injury (ALI) is a severe, life-threatening medical condition whose pathogenesis is linked to neutrophil infiltration of the lung. Activation and recruitment of neutrophils to the lung is mostly attributed to the production of chemokines NO, IL-6, for instance. This study aims to investigate lobeline ability in reducing NO production, and nitric oxide synthase (iNOs) expression. Lobeline was tested by inhibiting phosphorylation of mitogen-activated protein kinases (MAPKs), NF-κB and IκBα in LPS-stimulated RAW 264...
May 2016: Respiratory Physiology & Neurobiology
Marie Batisse-Lignier, Bruno Pereira, Pascal Motreff, Romain Pierrard, Christelle Burnot, Charles Vorilhon, Salwan Maqdasy, Béatrice Roche, Francoise Desbiez, Guillaume Clerfond, Bernard Citron, Jean-René Lusson, Igor Tauveron, Romain Eschalier
Pheochromocytoma and paraganglioma (PPG) are rare and late-diagnosed catecholamine secreting tumors, which may be associated with unrecognized and/or severe cardiomyopathies. We performed a computer-assisted systematic search of the electronic Medline databases using the MESH terms "myocarditis," "myocardial infarction," "Takotsubo," "stress cardiomyopathy," "cardiogenic shock", or "dilated cardiomyopathy," and "pheochromocytoma" or "paraganglioma" from 1961 to August 2012. All detailed case reports of cardiomyopathy due to a PPG, without coronary stenosis, and revealed by acute symptoms were included and analyzed...
December 2015: Medicine (Baltimore)
Palmira Cupo
Scorpion stings are currently the leading cause of venom-related injury to humans in Brazil and are a significant public health problem globally. Only scorpions of the Tityus genus are of medical importance in Brazil, and Tityus serrulatus is responsible for the most serious envenomations and deaths. The toxic effects of scorpion envenomation are due to a massive release of sympathetic and parasympathetic neurotransmitters; the severity is related to cardiac and hemodynamic changes, with cardiogenic shock and pulmonary edema contributing to the main causes of death...
November 2015: Revista da Sociedade Brasileira de Medicina Tropical
W W Liu, L F Xian, G M Tang, Z Y Cai, J Zheng, W G Xu
We are living in an environment full of gases, and any change in the concentration of a component of the air or contaminants (usually toxic) in the air may significantly threaten human health. Thus, to investigate the influence of gases in animal models it is helpful to elucidate the pathogenesis of gas-related injury. Although there are devices used for gas exposure in animals, there are still limitations in the establishment of these animal models, such as the change in gas concentration during the refreshing of water, food and litter, and the contamination of toxic gases released by animals...
September 2015: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
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