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stress induced pulmonary edema

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https://www.readbyqxmd.com/read/29737632/mesenchymal-stem-cell-microvesicles-restore-protein-permeability-across-primary-cultures-of-injured-human-lung-microvascular-endothelial-cells
#1
Shuling Hu, Jeonghyun Park, Airan Liu, JaeHoon Lee, Xiwen Zhang, Qi Hao, Jae-Woo Lee
Our previous study demonstrated that mesenchymal stem cell (MSC) microvesicles (MV) reduced lung inflammation, protein permeability, and pulmonary edema in endotoxin-induced acute lung injury in mice. However, the underlying mechanisms for restoring lung protein permeability were not fully understood. In this current study, we hypothesized that MSC MV would restore protein permeability across injured human lung microvascular endothelial cells (HLMVEC) in part through the transfer of angiopoietin-1 (Ang1) mRNA to the injured endothelium...
May 8, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29725493/intermittent-hypoxia-increases-the-severity-of-bleomycin-induced-lung-injury-in-mice
#2
Thomas Gille, Morgane Didier, Cécile Rotenberg, Eva Delbrel, Dominique Marchant, Angela Sutton, Nicolas Dard, Liasmine Haine, Nicolas Voituron, Jean-François Bernaudin, Dominique Valeyre, Hilario Nunes, Valérie Besnard, Emilie Boncoeur, Carole Planès
Background: Severe obstructive sleep apnea (OSA) with chronic intermittent hypoxia (IH) is common in idiopathic pulmonary fibrosis (IPF). Here, we evaluated the impact of IH on bleomycin- (BLM-) induced pulmonary fibrosis in mice. Methods: C57BL/6J mice received intratracheal BLM or saline and were exposed to IH (40 cycles/hour; FiO2 nadir: 6%; 8 hours/day) or intermittent air (IA). In the four experimental groups, we evaluated (i) survival; (ii) alveolar inflammation, pulmonary edema, lung oxidative stress, and antioxidant enzymes; (iii) lung cell apoptosis; and (iv) pulmonary fibrosis...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29722341/halogen-inhalation-induced-lung-injury-and-acute-respiratory-distress-syndrome
#3
REVIEW
Ting Zhou, Wei-Feng Song, You Shang, Shang-Long Yao, Sadis Matalon
Objective: Exposure to halogens, such as chlorine or bromine, results in environmental and occupational hazard to the lung and other organs. Chlorine is highly toxic by inhalation, leading to dyspnea, hypoxemia, airway obstruction, pneumonitis, pulmonary edema, and acute respiratory distress syndrome (ARDS). Although bromine is less reactive and oxidative than chlorine, inhalation also results in bronchospasm, airway hyperresponsiveness, ARDS, and even death. Both halogens have been shown to damage the systemic circulation and result in cardiac injury as well...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29685148/recurrent-inhibition-of-mitochondrial-complex-iii-induces-chronic-pulmonary-vasoconstriction-and-glycolytic-switch-in-the-rat-lung
#4
Olga Rafikova, Anup Srivastava, Ankit A Desai, Ruslan Rafikov, Stevan P Tofovic
BACKGROUND: Pulmonary arterial hypertension (PAH) is a fatal disease; however, the mechanisms directly involved in triggering and the progression of PAH are not clear. Based on previous studies that demonstrated a possible role of mitochondrial dysfunction in the pathogenesis of PAH, we investigated the effects of chronic inhibition of mitochondrial function in vivo in healthy rodents. METHODS: Right ventricle systolic pressure (RVSP) was measured in female rats at baseline and up to 24 days after inhibition of mitochondrial respiratory Complex III, induced by Antimycin A (AA, 0...
April 23, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29625389/high-molecular-weight-hyaluronan-attenuates-fine-particulate-matter-induced-acute-lung-injury-through-inhibition-of-ros-ask1-p38-jnk-mediated-epithelial-apoptosis
#5
Chenming Xu, Qiwen Shi, Leifang Zhang, Hang Zhao
Inhalation of fine particulate matter (PM2.5 ) is asscoiated with lung injury. High molecular weight hyaluronan (HMW-HA) is an essential constituent of extracellular matrix (ECM), exhibiting anti-oxidative and anti-inflammatory properties when administered by injection, inhalation, nebulization or gene delivery of HA synthases. The aim of the present study is to determine whether HMW-HA alleviates PM2.5 -induced acute lung injury (ALI) and investigate the underlying mechanisms. We observed that HMW-HA suppressed pathological injury, inflammation, oxidative stress, edema and epithelial damage caused by PM2...
March 30, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29621734/protective-effect-of-pristimerin-against-lps-induced-acute-lung-injury-in-mice
#6
Ahmed A Shaaban, Dalia H El-Kashef, Mohamed F Hamed, Dina S El-Agamy
Pristimerin (Pris) is a triterpenoid derivative obtained from Celastraceae and Hippocrateaceae families. This compound has been extensively tested for its potent anti-cancer activity against different types of tumors. However, its effects against acute lung injury (ALI) remain to be investigated. This study explored the efficacy of Pris to protect against lipopolysaccharide (LPS)-induced ALI and its possible pathways. Results have shown that Pris possesses potent protective activity against LPS-induced acute lung damage...
April 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29568898/adiponectin-protects-against-lung-ischemia-reperfusion-injury-in-rats-with-type-2-diabetes-mellitus
#7
Di Li, Lin-Lin Song, Juan Wang, Chao Meng, Xiao-Guang Cui
Adiponectin (APN) has been associated with the pathogenesis of acute brain, liver and heart injury. However, the role of APN in lung ischemia-reperfusion injury (LIRI) in diabetes mellitus remains unclear. To investigate this, the present study evaluated the effects of APN on lung dysfunction and pathological alterations in rats with type 2 diabetes mellitus via lung ischemia/reperfusion (I/R). The lung‑protective effects of APN globular domain (gAPN) in rats with type 2 diabetes mellitus were also investigated by measuring the oxygenation index, inflammatory cytokines, lung edema, histopathology, oxidative stress, apoptosis and the protein expression levels of phosphorylated 5'adenosine monophosphate‑activated protein kinase (p‑AMPK), endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS)...
March 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29512754/3-5-4-tri-o-acetylresveratrol-attenuates-seawater-inhalation-induced-acute-respiratory-distress-syndrome-via-thioredoxin-1-pathway
#8
Yilin Zhao, Lijie Ma, Ruixuan Wang, Tingting Chen, Xueying Liu, Faguang Jin
The protecting effects of 3,5,4'-tri-O-acetylresveratrol (AC-Res) on seawater inhalation-induced acute respiratory distress syndrome (ARDS) by interfering with the activation of thioredoxin-1 (Trx-1) pathway were evaluated. Seawater inhalation-induced ARDS was assessed by magnitude of pulmonary edema and lung inflammation. Oxidative stress was tested by T-SOD activity and MDA content in lungs and cells. Besides, Trx-1, nuclear factor erythroid 2-related factor 2 (Nrf2) and Txnip expression were measured to explore how seawater induced oxidative stress and the mechanism by which AC-Res attenuated seawater inhalation-induced ARDS...
June 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29502482/lycium-barbarum-polysaccharide-protects-against-lps-induced-ards-by-inhibiting-apoptosis-oxidative-stress-and-inflammation-in-pulmonary-endothelial-cells
#9
Lan Chen, Wen Li, Di Qi, Daoxin Wang
Acute respiratory distress syndrome (ARDS) is a heterogenous syndrome characterised by diffuse alveolar damage, with an increase in lung endothelial and epithelial permeability. Lycium barbarum polysaccharide (LBP), the most biologically active fraction of wolfberry, possesses antiapoptotic and antioxidative effects in distinct situations. In the present study, the protective effects and potential molecular mechanisms of LBP against lipopolysaccharide (LPS)-induced ARDS were investigated in the mice and in the human pulmonary microvascular endothelial cells (HPMECs)...
March 23, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29310390/takotsubo-cardiomyopathy-caused-by-acute-respiratory-stress-from-extubation-a-case-report
#10
Kohei Taniguchi, Syogo Takashima, Ryo Iida, Koshi Ota, Masahiko Nitta, Kazushi Sakane, Tomohiro Fujisaka, Nobukazu Ishizaka, Osamu Umegaki, Kazuhisa Uchiyama, Akira Takasu
RATIONAL: Takotsubo cardiomyopathy (TCM) is a transient systolic dysfunction of the left ventricular apex without stenosis of coronary arteries and is induced by various psychological and physical factors. TCM sometimes causes lethal complications such as arrhythmia, thrombogenesis, and even cardiac rupture, and thus it should be diagnosed appropriately and managed carefully. Intensive care unit (ICU) patients are exposed to overstress during the treatment process and therefore can are at potential risk for TCM...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29277898/glucose-6-phosphate-dehydrogenase-inhibition-attenuates-acute-lung-injury-through-reduction-in-nadph-oxidase-derived-reactive-oxygen-species
#11
A Nadeem, N O Al-Harbi, S F Ahmad, K E Ibrahim, N Siddiqui, M M Al-Harbi
Acute lung injury (ALI) is a heterogeneous disease with the hallmarks of alveolar capillary membrane injury, increased pulmonary oedema and pulmonary inflammation. The most common direct aetiological factor for ALI is usually parenchymal lung infection or haemorrhage. Reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) are thought to play an important role in the pathophysiology of ALI. Glucose-6-phosphate dehydrogenase (G6PD) plays an important role both in production of ROS as well as their removal through the supply of NADPH...
March 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29260443/medulla-oblongata-hemorrhage-and-reverse-takotsubo-cardiomyopathy
#12
Kevin T Gobeske, Maurice E Sarano, Jennifer E Fugate, Eelco F Wijdicks
BACKGROUND: Acute brain injury with strong surges of adrenergic outflow has resulted in takotsubo cardiomyopathy, but there are surprisingly few reports of takotsubo cardiomyopathy after intracranial hemorrhage, and none have been described from hemorrhage within the brainstem. RESULTS: We describe a patient with reverse and reversible cardiomyopathy following a hemorrhage in the lateral medulla oblongata. While it is limited in size, the location of the hemorrhage caused acute systolic failure with left ventricular ejection fraction of 27% and vasopressor requirement for cardiogenic shock and pulmonary edema...
December 19, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29225158/exendin-4-partly-ameliorates-hyperglycemia-mediated-tissue-damage-in-lungs-of-streptozotocin-induced-diabetic-mice
#13
Fusun Oztay, Serap Sancar-Bas, Selda Gezginci-Oktayoglu, Merve Ercin, Sehnaz Bolkent
Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion, - plays anti-inflammatory role in atherosclerosis, and has surfactant-releasing effects in lungs. GLP-1 analogues are used in diabetes therapy. This is the first study to investigate the effects of exendin-4, a GLP-1 receptor agonist, on lung injury in diabetic mice. BALB/c male mice were divided into four groups. The first group was given only citrate buffer, the second group was given only exendin-4, the third group was given only streptozotocin (STZ), and the fourth group was given both exendin-4 and STZ...
January 2018: Peptides
https://www.readbyqxmd.com/read/29081093/-the-protective-effect-of-n-acetylcysteine-on-acute-lung-injury-induced-by-pfib-inhalation
#14
L M Yang, J Zhao, H T Wang, X X Xu, Y M JIiao, R G Ding
Objective: To study the protective effect of N-acetylcysteine on acute lung injury induced by PFIB inhalation and its mechanism. Methods: Survival experiment: 48 male ICR (CD-1) mice were randomly divided into 4 groups, i. e., PFIB control group, NAC prevention group, NAC treatment group, and NAC prevention + treatment group, each group contains 12 animals. The mice of PFIB C group were exposed to PFIB without any treatment. The mice of NAC P group were exposed to PFIB 30min after NAC administration. The mice of NAC T group were exposed to PFIB 1h before NAC administration, The mice of NAC P+T group were administrated with NAC twice (30 min before and 1h after PFIB inhalation) ...
July 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29074492/autophagy-inhibitor-3-methyladenine-protects-against-endothelial-cell-barrier-dysfunction-in-acute-lung-injury
#15
Spencer A Slavin, Antony Leonard, Valerie Grose, Fabeha Fazal, Arshad Rahman
Autophagy is an evolutionarily conserved cellular process that facilitates the continuous recycling of intracellular components (organelles and proteins) and provides an alternative source of energy when nutrients are scarce. Recent studies have implicated autophagy in many disorders, including pulmonary diseases. However, the role of autophagy in endothelial cell (EC) barrier dysfunction and its relevance in the context of acute lung injury (ALI) remain uncertain. Here, we provide evidence that autophagy is a critical component of EC barrier disruption in ALI...
March 1, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29050744/-stress-dobutamine-echocardiography-or-resting-strain-rate-imaging-to-unveil-an-early-symptomatic-diabetic-cardiomyopathy
#16
F Aboukhoudir, I Aboukhoudir, S Rekik
Diabetes mellitus has been associated with changes in the structure and function of the myocardium manifesting in the early stages of the disease as subtle systolic and diastolic dysfunction; myocardial strain imaging has recently been favored over dobutamine stress echocardiography for early detection of diabetic cardiomyopathy. We report a case of an elderly diabetic patient presenting with pulmonary edema in whom at rest echocardiographic parameters including strain rate were all within normal range, while dobutamine stress echocardiography induced a deep systolic deterioration unmasking an early-stage diabetic cardiomyopathy...
November 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29017959/8-isoprostane-is-an-early-biomarker-for-oxidative-stress-in-chlorine-induced-acute-lung-injury
#17
Linda Elfsmark, Lina Ågren, Christine Akfur, Anders Bucht, Sofia Jonasson
Inhalation of chlorine (Cl2 ) may cause oxidative acute lung injury (ALI) characterized by pulmonary edema, pneumonitis, and hyperreactive airways. The aim of the study was to identify possible biomarkers for Cl2 -induced ALI. Female BALB/c mice were exposed to Cl2 for 15min using two protocols 1) concentration-dependent response (25-200ppm) and 2) time-kinetics (2h-14days post-exposure). Exposure to 50-200ppm Cl2 caused a concentration-dependent inflammatory response with increased expression of IL-1β, IL-6 and CXCL1/KC in bronchoalveolar lavage fluid 2-6h after exposure which was followed by increased lung permeability and a neutrophilic inflammation 12-24h post-exposure...
January 5, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/28945469/pharmacologic-protection-of-mitochondrial-dna-integrity-may-afford-a-new-strategy-for-suppressing-lung-ischemia-reperfusion-injury
#18
REVIEW
Yong B Tan, Sujata Mulekar, Olena Gorodnya, Michael J Weyant, Martin R Zamora, Jon D Simmons, Tiago Machuka, Mark N Gillespie
Lung ischemia-reperfusion (IR) injury contributes to post-transplant complications, including primary graft dysfunction. Decades of reports show that reactive oxygen species generated during lung IR contribute to pulmonary vascular endothelial barrier disruption and edema formation, but the specific target molecule(s) that "sense" injury-inducing oxidant stress to activate signaling pathways culminating in pathophysiologic changes have not been established. This review discusses evidence that mitochondrial DNA (mtDNA) may serve as a molecular sentinel wherein oxidative mtDNA damage functions as an upstream trigger for lung IR injury...
September 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28917022/epidemiology-pathogenesis-and-management-of-takotsubo-syndrome
#19
REVIEW
Shams Y-Hassan, Per Tornvall
Takotsubo syndrome is a recently recognized acute cardiac disease entity with a clinical presentation resembling that of an acute coronary syndrome. The typical takotsubo syndrome patient has a unique circumferential left (bi-) ventricular contraction abnormality profile that extends beyond a coronary artery supply territory and appears to follow the anatomical cardiac sympathetic innervation. The syndrome predominantly affects postmenopausal women and is often preceded by emotional or physical stress. Patients with predisposing factors such as malignancy and other chronic comorbidities are more prone to suffer from takotsubo syndrome...
February 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28904482/mathematics-of-ventilator-induced-lung-injury
#20
REVIEW
Ubaidur Rahaman
Ventilator-induced lung injury (VILI) results from mechanical disruption of blood-gas barrier and consequent edema and releases of inflammatory mediators. A transpulmonary pressure (PL ) of 17 cmH2 O increases baby lung volume to its anatomical limit, predisposing to VILI. Viscoelastic property of lung makes pulmonary mechanics time dependent so that stress (PL ) increases with respiratory rate. Alveolar inhomogeneity in acute respiratory distress syndrome acts as a stress riser, multiplying global stress at regional level experienced by baby lung...
August 2017: Indian Journal of Critical Care Medicine
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