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https://www.readbyqxmd.com/read/28548288/hypermineralization-and-high-osteocyte-lacunar-density-in-osteogenesis-imperfecta-type-v-bone-indicate-exuberant-primary-bone-formation
#1
Stéphane Blouin, Nadja Fratzl-Zelman, Francis H Glorieux, Paul Roschger, Klaus Klaushofer, Joan C Marini, Frank Rauch
In contrast to "classical" forms of Osteogenesis imperfecta (OI) types I to IV, caused by a mutation in COL1A1/A2, OI type V is due to a gain-of-function mutation in the IFITM5 gene, encoding the interferon-induced transmembrane protein 5, or bone-restricted ifitm-like protein (BRIL). Its phenotype distinctly differs from OI types I to IV by absence of blue sclerae and dentinogenesis imperfecta, by the occurrence of ossification disorders like hyperplastic callus and forearm interosseous membrane ossification...
May 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28548246/comparison-of-three-different-types-of-scaffolds-preseeded-with-human-bone-marrow-mononuclear-cells-on-the-bone-healing-in-a-femoral-critical-size-defect-model-of-the-athymic-rat
#2
Maren Janko, Julian Sahm, Alexander Schaible, Jan C Brune, Marlene Bellen, Katrin Schröder, Caroline Seebach, Ingo Marzi, Dirk Henrich
Large bone defects often pose major difficulties in orthopedic surgery. The application of long term cultured stem cells combined with a scaffold lead to a significant improvement of bone healing in recent experiments but is strongly restricted by EU-law. Bone marrow mononuclear cells (BMC), however, can be isolated and transplanted within few hours and have been proven effective in experimental models of bone healing. The effectivity of the BMC supported therapy might be influenced by the type of scaffold...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28547346/ketogenic-diet-compromises-both-cancellous-and-cortical-bone-mass-in-mice
#3
Xiuhua Wu, Zucheng Huang, Xiaomeng Wang, Zhaozong Fu, Junhao Liu, Zhiping Huang, Ganggang Kong, Xiaolin Xu, Jianyang Ding, Qingan Zhu
To clarify osteoporotic effects of ketogenic diet (KD) on cancellous and cortical bone compared with ovariectomy (OVX) in mice. Forty female C57BL/6J 8-week-old mice were randomly divided into SD+Sham, SD+OVX, KD+Sham, and KD+OVX groups, and fed for 12 weeks. The distal femur of trabecular bone and the middle femur of cortical bone were evaluated with Micro-CT scanning. The maximum bending force and stiffness of the tibia were calculated using a three-point bending test. Osteoblast and osteoclast expression of femur were identified using tartrate-resistant acid phosphatase (TRAP), collagen type I (CoLI), and osteocalcin (OCN) staining...
May 25, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28543599/optimization-of-screw-fixation-in-rat-bone-with-extracorporeal-shock-waves
#4
Marianne K E Koolen, Moyo C Kruyt, Amir A Zadpoor, F C Öner, Harrie Weinans, Olav P van der Jagt
Screw fixation in osteoporotic patients is becoming an increasing problem in orthopaedic surgery as deterioration of cortical and cancellous bone hamper biomechanical stability and screw fixation. This might result in delayed weight-bearing or failure of instrumentation. We hypothesized that local peri-operative shock wave treatment can optimize osseointegration and subsequent screw fixation. In eight female Wistar rats, two cancellous and two cortical bone screws were implanted in both femora and tibiae. Immediately after implantation, 3...
May 24, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28536801/induced-membrane-technique-using-beta-tricalcium-phosphate-for-reconstruction-of-femoral-and-tibial-segmental-bone-loss-due-to-infection-technical-tips-and-preliminary-clinical-results
#5
Gen Sasaki, Yoshinobu Watanabe, Wataru Miyamoto, Youichi Yasui, Shota Morimoto, Hirotaka Kawano
PURPOSE: This study aimed to provide preliminary evidence regarding effectiveness of grafting beta-tricalcium phosphate (β-TCP) combined with a cancellous autograft for treating nonunion of long bones in the lower extremity due to infection by evaluating clinical and radiological outcomes. METHODS: We retrospectively reviewed the clinical and radiological results in seven patients (six men, one woman; median age 39 years) treated by the induced membrane technique for nonunion of the femur or tibia due to infection...
May 24, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28523374/capturing-microscopic-features-of-bone-remodeling-into-a-macroscopic-model-based-on-biological-rationales-of-bone-adaptation
#6
Young Kwan Kim, Yoshitaka Kameo, Sakae Tanaka, Taiji Adachi
To understand Wolff's law, bone adaptation by remodeling at the cellular and tissue levels has been discussed extensively through experimental and simulation studies. For the clinical application of a bone remodeling simulation, it is significant to establish a macroscopic model that incorporates clarified microscopic mechanisms. In this study, we proposed novel macroscopic models based on the microscopic mechanism of osteocytic mechanosensing, in which the flow of fluid in the lacuno-canalicular porosity generated by fluid pressure gradients plays an important role, and theoretically evaluated the proposed models, taking biological rationales of bone adaptation into account...
May 18, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28513889/mechanically-induced-bone-formation-is-not-sensitive-to-local-osteocyte-density-in-rat-vertebral-cancellous-bone
#7
Erin N Cresswell, Thu M Nguyen, Michael W Horsfield, Adrian J Alepuz, Thomas A Metzger, Glen L Niebur, Christopher J Hernandez
Osteocytes play an integral role in bone by sensing mechanical stimuli and releasing signaling factors that direct bone formation. The importance of osteocytes in mechanotransduction suggests that regions of bone tissue with greater osteocyte populations are more responsive to mechanical stimuli. To determine the effects of osteocyte population on bone functional adaptation we applied mechanical loads to the 8(th) caudal vertebra of skeletally mature female Sprague Dawley rats (6 months of age, n = 8 loaded, n = 8 sham controls)...
May 17, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28513571/fat-sugar-and-bone-health-a-complex-relationship
#8
REVIEW
Li Tian, Xijie Yu
With people aging, osteoporosis is expected to increase notably. Nutritional status is a relatively easily-modified risk factor, associated with many chronic diseases, and is involved in obesity, diabetes, and coronary heart disease (CHD), along with osteoporosis. Nutrients, such as fats, sugars, and proteins, play a primary function in bone metabolism and maintaining bone health. In Western nations, diets are generally high in saturated fats, however, currently, the nutritional patterns dominating in China continue to be high in carbohydrates from starch, cereals, and sugars...
May 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28508515/extra-oral-digital-scanning-and-imaging-superimposition-for-volume-analysis-of-bone-remodeling-after-tooth-extraction-with-and-without-2-types-of-particulate-porcine-mineral-insertion-a-randomized-controlled-trial
#9
Antonio Barone, Paolo Toti, Giovan-Battista Menchini-Fabris, Giacomo Derchi, Simone Marconcini, Ugo Covani
BACKGROUND: Incorporation of bone substitute material into the extraction socket could minimize the edentulous ridge volume loss or maximize the bone formation within the healing area. PURPOSE: The aim of the study was to test the effectiveness in maintaining the volumetric contour of fresh extraction sockets grafted with or without 2 types of porcine biomaterials and covered with a resorbable barrier. MATERIALS AND METHODS: In the present multi-center single-blind randomized control trial, 55 patients underwent 1-tooth extraction, were surveyed, and randomly allocated to control- (25 sites, nat-group) or test groups (15 sites grafted with pre-hydrated collagenated cortico-cancellous porcine bone, coll-group, and 15 with cortical porcine bone, cort-group)...
May 16, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28507975/charcot-fracture-in-the-calcaneus-after-total-knee-arthroplasty-a-case-report
#10
Hirokazu Takai, Katsuhiko Kiyota, Nobutake Nakane, Tomoki Takahashi
INTRODUCTION: Only a few reports have described calcaneus fractures after total knee arthroplasty (TKA). Therefore, in this report, we describe a case of calcaneal avulsion fracture that occurred 5 weeks after a TKA in a relatively young male patient with syphilis. CASE REPORT: A 63-year-old man with syphilis had Charcot joint of the right knee. The patient developed severe varus deformity and contracture and experienced severe pain in the knee. TKA was performed to alleviate the pain and improve the patient's gait...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28507636/influence-of-number-of-implants-and-attachment-type-on-stress-distribution-in-mandibular-implant-retained-overdentures-finite-element-analysis
#11
Mohamed I El-Anwar, Eman A El-Taftazany, Hamdy A Hamed, Mohamed A Abd ElHay
AIM: This study aimed to compare the stresses generated by using two or four root form dental implants supporting mandibular overdentures that were retained with ball and locator attachments. METHODS: Under ANSYS environment, four 3D finite element models were prepared. These models simulated complete overdentures supported by two or four implants with either ball or locator attachments as a connection mechanism. The models' components were created by CAD/CAM package then were imported to ANSYS...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28506162/brodie-s-abscess-of-the-radius-in-a-child
#12
N Takeuchi, Y Matsumoto, T Okada, M Hanada, H Bekki, Y Iwamoto
We herein report an unusual case of Brodie's abscess of the radius in a child. A 13-year-old boy presented with pain on his right distal forearm. A plain radiograph showed an 8 cm translucent lesion in the distal radius. MRI showed a penumbra sign on the T1-weighted image, hyperintensity on T2-weighted images, and ring enhancement on the contrast-enhanced T1 image. (18)F-FDG PET/CT images showed an uptake at the margin of the radius. Curettage and iliac cancellous bone grafting were undertaken for Brodie's abscess...
June 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28503349/medial-malleolar-fractures-an-anatomic-survey-determining-the-ideal-screw-length
#13
P J Labronici, R E Pires, M V Franco, R Freitas, G C Araújo, R S Pires E Albuquerque, V S Gameiro, K Jeray
BACKGROUND: Medial malleolar fractures are frequent, and their treatment is familiar to the orthopedic surgeon. Lag screw fixation using partially threaded screws remains the standard treatment method for medial malleolar fractures. However, the literature lacks a defined method for selecting lag screw length, relying more so on the empiric choice of the surgeon. AIM: The aim of this study is to help define the ideal lag screw length for medial melleolar fracture fixation...
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28500959/biomechanical-evaluation-of-implant-supported-prosthesis-with-various-tilting-implant-angles-and-bone-types-in-atrophic-maxilla-a-finite-element-study
#14
Zeynep Gümrükçü, Yavuz Tolga Korkmaz, Fatih Mehmet Korkmaz
BACKGROUND AND OBJECTIVE: The purpose of this study is to evaluate and compare bone stress that occurs as a result of using vertical implants with simultaneous sinus augmentation with bone stress generated from oblique implants without sinus augmentation in atrophic maxilla. METHODS: Six, three-dimensional (3D) finite element (FE) models of atrophic maxilla were generated with SolidWorks software. The maxilla models were varied for two different bone types. Models 2a, 2b and 2c represent maxilla models with D2 bone type...
May 4, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28498072/paravertebral-foramen-screw-fixation-for-posterior-cervical-spine-fusion-biomechanical-study-and-description-of-a-novel-technique
#15
Satoshi Maki, Masaaki Aramomi, Yusuke Matsuura, Takeo Furuya, Mitsutoshi Ota, Yasushi Iijima, Junya Saito, Takane Suzuki, Chikato Mannoji, Kazuhisa Takahashi, Masashi Yamazaki, Masao Koda
OBJECTIVE Fusion surgery with instrumentation is a widely accepted treatment for cervical spine pathologies. The authors propose a novel technique for subaxial cervical fusion surgery using paravertebral foramen screws (PVFS). The authors consider that PVFS have equal or greater biomechanical strength than lateral mass screws (LMS). The authors' goals of this study were to conduct a biomechanical study of PVFS, to investigate the suitability of PVFS as salvage fixation for failed LMS, and to describe this novel technique...
May 12, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28492108/three-dimensional-simulation-of-quantitative-ultrasound-in-cancellous-bone-using-the-echographic-response-of-a-metallic-pin
#16
Yoshiki Nagatani, Séraphin Guipieri, Vu-Hieu Nguyen, Christine Chappard, Didier Geiger, Salah Naili, Guillaume Haїat
Degenerative discopathy is a common pathology that may require spine surgery. A metallic cylindrical pin is inserted into the vertebral body to maintain soft tissues and may be used as a reflector of ultrasonic wave to estimate bone density. The first aim of this paper is to validate a three-dimensional (3-D) model to simulate the ultrasonic propagation in a trabecular bone sample in which a metallic pin has been inserted. We also aim at determining the effect of changes of bone volume fraction (BV/TV) and of positioning errors on the quantitative ultrasound (QUS) parameters in this specific configuration...
May 1, 2017: Ultrasonic Imaging
https://www.readbyqxmd.com/read/28488727/differences-in-sodium-fluoride-18-uptake-in-the-normal-skeleton-depending-on-the-location-and-characteristics-of-the-bone
#17
Shintaro Nawata, Tomohiro Kaneta, Matsuyoshi Ogawa, Yoshinobu Ishiwata, Naomi Kobayashi, Ayako Shishikura-Hino, Keisuke Yoshida, Yutaka Inaba, Tomoyuki Saito, Tomio Inoue
AIM: The aim of this study was to evaluate the normal distribution of sodium fluoride-18 (NaF-18) and to clarify the differences in uptake according to location and the type of the bone using positron emission tomography (PET) / computed tomography (CT). METHODS: We retrospectively reviewed NaF-18 PET/CT images from 30 patients with hip joint disorders. PET/CT scans were performed 40 min after injection of approximately 185 MBq of NaF-18. To evaluate the relationship between the distribution of NaF-18 uptake and bone density, we compared the maximum standardised uptake values (SUVmax) on PET and the Hounsfield Units (HUs) on CT of the lumbar vertebra, ilium, and proximal and distal femurs...
May 10, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28485078/tubular-open-porous-%C3%AE-tcp-plcl-scaffolds-as-guiding-structure-for-segmental-bone-defect-regeneration-in-a-novel-sheep-model
#18
Anne-Marie Pobloth, Hanna Schell, Ansgar Petersen, Katleen Beierlein, Christian Kleber, Katharina Schmidt-Bleek, Georg N Duda
Large segmental bone defect reconstruction with sufficient functional restoration is one of the most demanding challenges in orthopedic surgery. Available regenerative treatment options, as the vascularized bone graft transfer, the Masquelet technique or the Ilizarov distraction osteogenesis, are associated with specific indications and distinct limitations. As an alternative, a hollow cylindrical ceramic-polymer composite scaffold (beta-tricalcium phosphate and poly-lactid co-ε- caprolactone), facilitating a strong surface guiding effect for tissue ingrowth (group 1; n = 6) was investigated here...
May 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28484549/thoracic-psammomatous-spinal-meningioma-with-osseous-metaplasia-a-very-rare-case-report
#19
Akhil Prakash, Shashank Mishra, Ruchi Tyagi, Prakash C Attri, Amit Bhatnagar, Sandeep Kansal
Thoracic spinal psammomatous meningioma is a rare subtype of meningioma. Among diverse types of mesenchymal differentiation, osseous metaplasia is found to be still rarer. We are presenting a new case of thoracic psammomatous spinal meningioma with osseous metaplasia in a middle aged female which that gives a sense of cancellous bone in the spinal canal. To conclude, meningiomas with osseous metaplasia are very rare tumors that complicate the surgical removal in certain cases. Ossification, if predicted prior to operation with computed tomography reconstruction, makes planning of removal easier...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28481509/bioinspired-smart-coating-with-superior-tribological-performance
#20
Shuangjian Li, Yulong An, Xiaoqin Zhao, Huidi Zhou, Jianmin Chen, Guoliang Hou
Inspired by the structure of cancellous bone and the nutrition metabolism of articular cartilage, we present a novel concept for a synthetic articular-cartilage-like material. The bioinspired material possesses a low coefficient of friction even under ultrahigh loads and has an extremely long lifetime. Furthermore, the composite shows zero-wear behavior and causes negligible wear damage to the friction pair. The superior tribological performance is attributed to the spontaneously generated articular-cartilage-like layer, which is constantly replenished by frictional heat and pressure...
May 10, 2017: ACS Applied Materials & Interfaces
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