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https://www.readbyqxmd.com/read/28927930/biodegradable-and-adjustable-sol-gel-glass-based-hybrid-scaffolds-from-multi-armed-oligomeric-building-blocks
#1
Christian Kascholke, Stephan Hendrikx, Tobias Flath, Dzmitry Kuzmenka, Hans-Martin Dörfler, Dirk Schumann, Mathias Gressenbuch, F Peter Schulze, Michaela Schulz-Siegmund, Michael C Hacker
Biodegradability is a crucial characteristic to improve the clinical potential of sol-gel-derived glass materials. To this end, a set of degradable organic/inorganic class II hybrids from a tetraethoxysilane(TEOS)-derived silica sol and oligovalent cross-linker oligomers containing oligo(D,L-lactide) domains was developed and characterized. A series of 18 oligomers (Mn: 1100-3200 Da) with different degrees of ethoxylation and varying length of oligoester units was established and chemical composition was determined...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28926388/opportunistic-use-of-ct-imaging-for-osteoporosis-screening-and-bone-density-assessment-a-qualitative-systematic-review
#2
Elizabeth B Gausden, Benedict U Nwachukwu, Joseph J Schreiber, Dean G Lorich, Joseph M Lane
BACKGROUND: The purpose of this study was to determine the clinical opportunities for the use of computed tomography (CT) imaging for inferring bone quality and to critically analyze the correlation between dual x-ray absorptiometry (DXA) and diagnostic CT as reported in the literature. METHODS: A systematic review of the MEDLINE database was performed in February 2016 using the PubMed interface. The inclusion criteria were English language, studies performed using living human subjects, studies pertaining to orthopaedics, use of conventional diagnostic CT scans, studies that measured cancellous bone, and studies that reported Hounsfield unit (HU) measurements directly rather than a computed bone mineral density...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28924020/microindentation-a-tool-for-measuring-cortical-bone-stiffness-a-systematic-review
#3
M Arnold, S Zhao, S Ma, F Giuliani, U Hansen, J P Cobb, R L Abel, O Boughton
OBJECTIVES: Microindentation has the potential to measure the stiffness of an individual patient's bone. Bone stiffness plays a crucial role in the press-fit stability of orthopaedic implants. Arming surgeons with accurate bone stiffness information may reduce surgical complications including periprosthetic fractures. The question addressed with this systematic review is whether microindentation can accurately measure cortical bone stiffness. METHODS: A systematic review of all English language articles using a keyword search was undertaken using Medline, Embase, PubMed, Scopus and Cochrane databases...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28919430/role-of-subchondral-bone-properties-and-changes-in-development-of-load-induced-osteoarthritis-in-mice
#4
Olufunmilayo O Adebayo, Frank C Ko, Philip T Wan, Steven R Goldring, Mary B Goldring, Timothy M Wright, Marjolein C H van der Meulen
OBJECTIVE: Animal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression. Thus, we investigated the role of SCB properties and its effects on load-induced OA progression by applying a tibial loading model on two distinct mouse strains treated with alendronate (ALN). DESIGN: Cyclic compression was applied to the left tibia of 26-week-old male C57Bl/6 (B6, low bone mass) and FVB (high bone mass) mice...
September 14, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28914105/bone-and-subcutaneous-adipose-tissue-pharmacokinetics-of-vancomycin-in-total-knee-replacement-patients
#5
Mats Bue, Mikkel Tøttrup, Pelle Hanberg, Otto Langhoff, Hanne Birke-Sørensen, Theis M Thillemann, Torben L Andersson, Kjeld Søballe
Background and purpose - The incidence of orthopedic methicillin-resistant Staphylococcus aureus (MRSA) infections is increasing. Vancomycin may therefore play an increasingly important role in orthopedic perioperative antimicrobial prophylaxis. Studies investigating perioperative bone and soft tissue concentrations of vancomycin are sparse and challenged by a lack of appropriate methods. We assessed single-dose plasma, subcutaneous adipose tissue (SCT) and bone concentrations of vancomycin using microdialysis in male patients undergoing total knee replacement...
September 15, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28906014/development-and-initial-validation-of-a-novel-smoothed-particle-hydrodynamics-based-simulation-model-of-trabecular-bone-penetration-by-metallic-implants
#6
Sloan A Kulper, Christian X Fang, Xiaodan Ren, Margaret Guo, K Y Sze, Frankie Kl Leung, William W Lu
A novel computational model of implant migration in trabecular bone was developed using smoothed-particle hydrodynamics (SPH), and an initial validation was performed via correlation with experimental data. Six fresh-frozen human cadaveric specimens measuring 10 × 10 × 20 mm were extracted from the proximal femurs of female donors (mean age of 82 years, range 75-90, BV/TV ratios between 17.88-30.49%). These specimens were then penetrated under axial loading to a depth of 10 mm with 5 mm diameter cylindrical indenters bearing either flat or sharp/conical tip designs similar to blunt and self-tapping cancellous screws, assigned in a random manner...
September 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28900671/-wrist-arthrodesis-with-a%C3%A2-fixed-angle-low-profile-fusion-plate-without-carpometacarpal-joint-fixation
#7
REVIEW
S Köhler, K Koch, A Arsalan-Werner, I M Mehling, J Seegmüller, H Krimmer, Michael Sauerbier
OBJECTIVE: Total wrist arthrodesis to improve functional use of the hand by reducing pain and increasing grip strength. INDICATIONS: Painful destruction of the radio- and midcarpal joints. CONTRAINDICATIONS: Analgesia and satisfactory hand function after motion-preserving surgical or conservative treatment. Chronic joint infection. SURGICAL TECHNIQUE: Posterior approach to the wrist. Removal of articular surfaces destroyed all the way down to cancellous bone...
September 12, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28893145/non-vascularized-iliac-bone-grafting-for-scaphoid-nonunion-with-avascular-necrosis
#8
Jihyeung Kim, Jin Woo Park, Jeehyeok Chung, Kee Jeong Bae, Hyun Sik Gong, Goo Hyun Baek
We present the surgical outcomes of non-vascularized bone grafting taken from the iliac crest in 24 patients with scaphoid nonunion and avascular necrosis. The Fisk-Fernandez technique was used in 11 patients, and cancellous bone grafting was used in 13 patients. Bony union was achieved in 22 of the 24 patients. Non-vascularized iliac bone grafting can be used for the surgical management of scaphoid nonunion with avascular necrosis. Although revascularization of the proximal fragment after surgery was not evaluated, bony union was confirmed in nearly all patients...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28888901/oral-administration-of-undenatured-native-chicken-type-ii-collagen-uc-ii-diminished-deterioration-of-articular-cartilage-in-a-rat-model-of-oa
#9
Cedo M Bagi, Edwin R Berryman, Steve Teo, Nancy E Lane
OBJECTIVE: The aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent excessive articular cartilage deterioration in a rat model of osteoarthritis (OA). METHODS: Twenty male rats were subjected to partial medial meniscectomy tear (PMMT) surgery to induce OA. Immediately after the surgery ten rats received vehicle and another ten rats oral daily dose of UC-II at 0.66 mg/kg for a period of 8 weeks. In addition ten naïve rats were used as an intact control and another 10 rats received sham surgery...
September 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28884628/the-effect-of-tannic-acid-on-bone-mechanical-and-geometric-properties-bone-density-and-trabecular-histomorphometry-as-well-as-the-morphology-of-articular-and-growth-cartilages-in-rats-co-exposed-to-cadmium-and-lead-is-dose-dependent
#10
Ewa Tomaszewska, Piotr Dobrowolski, Anna Winiarska-Mieczan, Małgorzata Kwiecień, Siemowit Muszyński, Agnieszka Tomczyk
Cadmium (Cd) and lead (Pb) are toxic elements that accumulate to the largest extent in bones. Rats were used to investigate whether tannic acid (TA; 0.5%, 1.0%, 1.5%. 2.0%, or 2.5%) would have a protective effect on the structure and properties of bones in the case of exposure to Cd and Pb (diet: 7 mg Cd/kg and 50 mg Pb/kg) for 6 weeks. The effects of administration of TA in Cd- and Pb-poisoned rats on bone characteristics and the morphology of articular and growth cartilages were determined. All the rats administered Cd and Pb had an enhanced Cd and Pb concentration in blood plasma and bone and reduced bone Ca content irrespective of the TA administration...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28883516/effects-of-low-intensity-pulsed-electromagnetic-fields-on-bone-microarchitecture-mechanical-strength-and-bone-turnover-in-type-2-diabetic-db-db-mice
#11
Jianjun Li, Zhaobin Zeng, Yantao Zhao, Da Jing, Chuhua Tang, Yin Ding, Xue Feng
Type 2 diabetic patients have impaired bone quality, leading to increased fracture risk. Substantial evidence demonstrates that pulsed electromagnetic fields (PEMF) could resist osteopenia/osteoporosis induced by estrogen deficiency and disuse. However, the effects of PEMF on osteopenia/osteoporosis associated with diabetes, especially for more prevalent type 2 diabetes, remain poorly understood. We herein investigated the skeletal effects and mechanisms of PEMF (15 Hz, 20 Gs) on leptin receptor-deficient db/db mice with typical type 2 diabetic symptoms...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882369/3d-printed-tcp-based-scaffold-incorporating-vegf-loaded-plga-microspheres-for-craniofacial-tissue-engineering
#12
F Fahimipour, M Rasoulianboroujeni, E Dashtimoghadam, K Khoshroo, M Tahriri, F Bastami, D Lobner, L Tayebi
OBJECTIVE: Vascularization is a critical process during bone regeneration/repair and the lack of tissue vascularization is recognized as a major challenge in applying bone tissue engineering methods for cranial and maxillofacial surgeries. The aim of our study is to fabricate a vascular endothelial growth factor (VEGF)-loaded gelatin/alginate/β-TCP composite scaffold by 3D printing method using a computer-assisted design (CAD) model. METHODS: The paste, composed of (VEGF-loaded PLGA)-containing gelatin/alginate/β-TCP in water, was loaded into standard Nordson cartridges and promptly employed for printing the scaffolds...
September 4, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28882348/hemostasis-and-safety-of-a-novel-fibrin-dressing-versus-standard-gauze-in-bleeding-cancellous-bone-in-a-caprine-spine-surgery-model
#13
C Timothy Floyd, Rodolfo A Padua, Curtis E Olson
BACKGROUND: Decorticated bone is a significant source of blood loss in scoliosis surgery. Current hemostatic methods include packed gauze (GS), physical barriers such as bone wax, and xenograft collagen-based materials. We assessed the safety and efficacy of a novel fibrin dressing (dextran-thrombin-fibrinogen [DTF]) compared to GS. This dressing comprises lyophilized thrombin and fibrinogen embedded in an elastic electrospun nanofiber dextran matrix. PURPOSE: The study tests the hypothesis that DTF is more efficacious than GS in control of bleeding from cancellous bone...
September 2017: Spine Deformity
https://www.readbyqxmd.com/read/28880058/acromegaly-and-bone
#14
Filippo Maffezzoni, Anna M Formenti
INTRODUCTION: Growth hormone (GH) and insulin-like growth factor-I (IGF-1) have pleiotropic effects on the skeleton throughout the lifespan by influencing bone formation and resorption. Despite these positive effects on skeletal metabolism, in presence of GH and IGF-1 excess, bone turnover increases excessively leading to deterioration of bone microarchitecture and high risk of fragility fractures, thereby impairing quality of life. EVIDENCE ACQUISITION: Coexistent hypogonadism, diabetes mellitus, hypovitaminosis D, hyperparathyroidism and over-replacement with glucocorticoids impair bone framework, however, the effects of acromegaly on bone mineral density (BMD) are still controversial and despite normalization of bone turnover after treatment, the risk for fractures remains increased...
September 7, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28874773/cortical-and-trabecular-morphology-is-altered-in-the-limb-bones-of-mice-artificially-selected-for-faster-skeletal-growth
#15
Saira Farooq, Shannon Leussink, Leah M Sparrow, Marta Marchini, Hayley M Britz, Sarah L Manske, Campbell Rolian
Bone strength is influenced by mineral density and macro- and microstructure. Research into factors that contribute to bone morphology and strength has focused on genetic, environmental and morphological factors (e.g., body mass index), but little is known regarding the impact of rates of skeletal elongation on adult skeletal morphology and strength. Using micro-CT, we examined the impact of rates of skeletal elongation on bone cortical and trabecular morphology, and on rates of estrogen-dependent bone loss in the tibia in CD-1 mice, and in mice with accelerated skeletal growth (Longshanks)...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874642/measurement-of-crestal-cortical-bone-thickness-at-implant-site-a-cone-beam-computed-tomography-study
#16
Ajai Gupta, Suprabha Rathee, Jaihans Agarwal, Renu B Pachar
AIM: Dental implants have emerged as a new treatment modality for the majority of patients complaining of missing teeth. Bone quantity and bone quality are among various factors which ensure the longevity of dental implant in the patient's mouth. The assessment of cortical bone thickness of the outer layer and the cancellous bone density by cone beam computed tomography (CBCT) has proved beneficial for the patient. This study aimed at presurgical measurement of crestal bone thickness at various implant sites using CBCT images...
September 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28871814/osseous-changes-in-patients-with-medicationrelatedosteonecrosis-of-the-jaws
#17
Zeynep Burcin Gönen, Canay Yillmaz Asan, Gökmen Zararsiz, Erdem Kiliç, Alper Alkan
OBJECTIVES: Medication-Related Osteonecrosis of the Jaw (MRONJ) is a severe side effect of antiresorptive agents. The aim of this study was to investigate the osseous changes in patients with MRONJ. METHODS: Cone Beam Computed Tomography (CBCT) images of 25 patients with MRONJ and controls were retrospectively evaluated. Buccal, lingual, apical cortical bone thicknesses; buccal, lingual, apical intracortical and cancellous bone density; diameter of mental foramen and incisive canal, and width of mental foramen were measured...
September 5, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28866187/interconnected-porosity-analysis-by-3d-x-ray-microtomography-and-mechanical-behavior-of-biomimetic-organic-inorganic-composite-materials
#18
S Alonso-Sierra, R Velázquez-Castillo, B Millán-Malo, R Nava, L Bucio, A Manzano-Ramírez, H Cid-Luna, E M Rivera-Muñoz
Hydroxyapatite-based materials have been used for dental and biomedical applications. They are commonly studied due to their favorable response presented when used for replacement of bone tissue. Those materials should be porous enough to allow cell penetration, internal tissue growth, vascular incursion and nutrient supply. Furthermore, their morphology should be designed to guide the growth of new bone tissue in anatomically applicable ways. In this work, the mechanical performance and 3D X-ray microtomography (X-ray μCT) study of a biomimetic, organic-inorganic composite material, based on hydroxyapatite, with physicochemical, structural, morphological and mechanical properties very similar to those of natural bone tissue is reported...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28866149/three-dimensional-finite-element-analysis-of-occlusal-splint-and-implant-connection-on-stress-distribution-in-implant-supported-fixed-dental-prosthesis-and-peri-implantal-bone
#19
Vívian Dos Santos Marsico, Roberto Brunow Lehmann, Cristiane Aparecida de Assis Claro, Marina Amaral, Rafael Pino Vitti, Ana Christina Claro Neves, Lais Regiane da Silva Concilio
The aim of this study was to investigate the influence of occlusal splint therapy on the stress distribution of implant-supported fixed dental prosthesis (FDP) and peri-implantal bone structures using three-dimensional (3D) finite element analysis (FEA). The system consisted of two implants (positioned on region of second premolar and second molar) as retainers of fixed porcelain-fused-to-metal 3-unit FDP (first molar as pontic element). Two implant connections systems (external and internal hexagon) were tested...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28865450/elution-kinetics-of-vancomycin-and-gentamicin-from-carriers-and-their-effects-on-mesenchymal-stem-cell-proliferation-an-in-vitro-study
#20
Tomas Kucera, Lenka Ryskova, Tomas Soukup, Jana Malakova, Eva Cermakova, Pavel Mericka, Jakub Suchanek, Pavel Sponer
BACKGROUND: Musculoskeletal infections remain a major complication in orthopedic surgery. The local delivery of antibiotics provides the high levels required to treat an infection without systemic toxicity. However, the local toxicity of antibiotic carriers to the mesenchymal stem cells, as a result of both the peak concentrations and the type of carrier, may be significant. METHODS: To address this concern, the elution kinetics of vancomycin and gentamicin from several commercially available antibiotic carriers and several carriers impregnated by a surgeon (10 ml of each sterile carrier were manually mixed with a 500 mg vancomycin and an 80 mg gentamicin solution, and the duration of impregnation was 30 min) were assessed...
September 2, 2017: BMC Musculoskeletal Disorders
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