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https://www.readbyqxmd.com/read/28723300/interest-in-using-mobile-technology-to-help-self-manage-alcohol-use-among-persons-living-with-hiv-a-florida-cohort-cross-sectional-study
#1
J Danielle Sharpe, Zhi Zhou, César G Escobar-Viera, Jamie P Morano, Robert J Lucero, Gladys E Ibañez, Mark Hart, Christa L Cook, Robert L Cook
BACKGROUND: Alcohol consumption at hazardous levels is more prevalent and associated with poor health outcomes among persons living with HIV (PLWH). Although PLWH are receptive to using technology to manage health issues, it is unknown whether a cell phone app to self-manage alcohol use would be acceptable among PLWH who drink. The objectives of this study were to determine factors associated with interest in an app to self-manage drinking and to identify differences in baseline mobile technology use among PLWH by drinking level...
July 19, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28723276/can-an-app-help-identify-psychomotor-function-impairments-during-drinking-occasions-in-the-real-world-a-mixed-method-pilot-study
#2
Brian Suffoletto, Akash Goyal, Juan Carlos Puyana, Tammy Chung
BACKGROUND: Being able to measure the acute effects of alcohol consumption on psychomotor functions in natural settings could be useful in injury prevention interventions. This study examined the feasibility and acceptability of collecting app-based measures of information processing, working memory and gait stability during times of typical alcohol consumption among young adults. METHODS: Ten young adults (aged 21-26) with hazardous drinking completed a baseline assessment and ecological momentary assessments (EMA) on 4 consecutive Fridays and Saturdays, every hour from 8pm to 12am...
July 19, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28723111/augmented-reality-for-real-time-detection-and-interpretation-of-colorimetric-signals-generated-by-paper-based-biosensors
#3
Steven M Russell, Antonio Doménech-Sánchez, Roberto de la Rica
Colorimetric tests are becoming increasingly popular in point-of-need analyses due to the possibility of detecting the signal with the naked eye, which eliminates the utilization of bulky and costly instruments only available in laboratories. However, colorimetric tests may be interpreted incorrectly by nonspecialists due to disparities in color perception or a lack of training. Here we solve this issue with a method that not only detects colorimetric signals but also interprets them so that the test outcome is understandable for anyone...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722404/high-performance-colorimetric-detection-of-thiosulfate-by-using-silver-nanoparticles-for-smartphone-based-analysis
#4
Chen Dong, Zhuqing Wang, Yujie Zhang, Xuehua Ma, M Zubair Iqbal, Lijing Miao, Zhuangwei Zhou, Zheyu Shen, Aiguo Wu
Developing thiosulfate (S2O32-) sensors with silver nanoparticles (AgNPs) for analysis of aqueous solutions with the interference of other anions remains challenging. In this study, we propose a new strategy for excellent selective colorimetric detection of S2O32-. The non-morphological transition of AgNPs leading to a color change from yellow to brown is verified by UV-vis, TEM, DLS, SEM, and XPS analyses. The sensor exhibits high sensitivity with detection limits of 1.0 µM by naked-eye determination and 0...
July 19, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722194/effects-of-cholesterol-transport-inhibitor-u18666a-on-app-metabolism-in-rat-primary-astrocytes
#5
Hongyan Yang, Yanlin Wang, Satyabrata Kar
Amyloid β (Aβ) peptides generated from the amyloid precursor protein (APP) play an important role in the degeneration of neurons and development of Alzheimer's disease (AD). Current evidence indicates that high levels of cholesterol-which increase the risk of developing AD-can influence Aβ production in neurons. However, it remains unclear how altered level/subcellular distribution of cholesterol in astrocytes can influence APP metabolism. In this study, we evaluated the effects of cholesterol transport inhibitor U18666A-a class II amphiphile that triggers redistribution of cholesterol within the endosomal-lysosomal (EL) system-on APP levels and metabolism in rat primary cultured astrocytes...
July 19, 2017: Glia
https://www.readbyqxmd.com/read/28721361/role-of-endoplasmic-reticulum-stress-in-learning-and-memory-impairment-and-alzheimer-s-disease-like-neuropathology-in-the-ps19-and-app-swe-mouse-models-of-tauopathy-and-amyloidosis
#6
Denise Isabelle Briggs, Erwin Defensor, Pooneh Memar Ardestani, Bitna Yi, Michelle Halpain, Guy Seabrook, Mehrdad Shamloo
Emerging evidence suggests that endoplasmic reticulum (ER) stress may be involved in the pathogenesis of Alzheimer's disease (AD). Recently, pharmacological modulation of the eukaryotic translation initiation factor-2 (eIF2α) pathway was achieved using an integrated stress response inhibitor (ISRIB). While members of this signaling cascade have been suggested as potential therapeutic targets for neurodegeneration, the biological significance of this pathway has not been comprehensively assessed in animal models of AD...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28721032/-11-c-pib-pet-imaging-reveals-that-amyloid-deposition-in-cases-with-early-onset-alzheimer-s-disease-in-the-absence-of-known-mutations-retains-higher-levels-of-pib-in-the-basal-ganglia
#7
Young Chul Youn, Jae-Won Jang, Su-Hyun Han, HyeRyoun Kim, Ju-Won Seok, Jun Soo Byun, Kwang-Yeol Park, Seong Soo A An, In Kook Chun, SangYun Kim
PURPOSE: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease (LOAD). We examined the effects of age at onset on the burden and distribution of β-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent. METHODS: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone (11)C-labeled Pittsburgh compound B-positron emission tomography imaging...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28720751/exploring-the-perspectives-of-clinical-professionals-and-support-staff-on-implementing-supported-self-management-for-asthma-in-uk-general-practice-an-imp-2-art-qualitative-study
#8
Susan Morrow, Luke Daines, Sharon Wiener-Ogilvie, Liz Steed, Lorna McKee, Ann-Louise Caress, Stephanie J C Taylor, Hilary Pinnock
Despite an overwhelming evidence base, supported self-management of asthma is poorly implemented into routine practice. Strategies for implementation must address organisational routines, as well as provide resources for patients and training to improve professionals' skills. We aimed to explore the priority that primary care practices attach to asthma self-management, to describe their existing asthma management routines, and to generate innovative implementation strategies. We recruited 33 participants (23 general practitioners; seven nurses; three administrative staff) from 14 general practices...
July 18, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28720718/phosphorylation-of-amyloid-precursor-protein-by-mutant-lrrk2-promotes-aicd-activity-and-neurotoxicity-in-parkinson-s-disease
#9
Zhong-Can Chen, Wei Zhang, Ling-Ling Chua, Chou Chai, Rong Li, Lin Lin, Zhen Cao, Dario C Angeles, Lawrence W Stanton, Jian-He Peng, Zhi-Dong Zhou, Kah-Leong Lim, Li Zeng, Eng-King Tan
Mutations in LRRK2, which encodes leucine-rich repeat kinase 2, are the most common genetic cause of familial and sporadic Parkinson's disease (PD), a degenerative disease of the central nervous system that causes impaired motor function and, in advanced stages, dementia. Dementia is a common symptom of another neurodegenerative disease, Alzheimer's disease, and research suggests that there may be pathophysiological and genetic links between the two diseases. Aggregates of β amyloid [a protein produced through cleavage of amyloid precursor protein (APP)] are seen in both diseases and in PD patients carrying G2019S-mutant LRRK2...
July 18, 2017: Science Signaling
https://www.readbyqxmd.com/read/28720557/comparing-mobile-health-strategies-to-improve-medication-adherence-for-veterans-with-coronary-heart-disease-mobile4meds-protocol-for-a-mixed-methods-study
#10
Linda G Park, Eileen G Collins, Janet K Shim, Mary A Whooley
BACKGROUND: Adherence to antiplatelet medications is critical to prevent life threatening complications (ie, stent thrombosis) after percutaneous coronary interventions (PCIs), yet rates of nonadherence range from 21-57% by 12 months. Mobile interventions delivered via text messaging or mobile apps represent a practical and inexpensive strategy to promote behavior change and enhance medication adherence. OBJECTIVE: The Mobile4Meds study seeks to determine whether text messaging or a mobile app, compared with an educational website control provided to all Veterans, can improve adherence to antiplatelet therapy among patients following acute coronary syndrome (ACS) or PCI...
July 18, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28720071/developmental-expression-and-dysregulation-of-mir-146a-and-mir-155-in-down-s-syndrome-and-mouse-models-of-down-s-syndrome-and-alzheimer-s-disease
#11
A Arena, A M Iyer, I Milenkovic, G G Kovács, I Ferrer, M Perluigi, E Aronica
miR-146a and miR-155 are key regulators of the innate immune response. We hypothesized that an inflammation-mediated dysregulation of these miRNAs may occur in patients with Down syndrome (DS) and Alzheimer's disease (AD). The miRNA expression patterns were investigated by in situ hybridization in developing hippocampus from controls, patients with DS and in adults with AD pathology (DS and sporadic AD; sAD). quantitative real-time PCR was employed to evaluate the miRNA levels in the hippocampus of sAD and in mouse models of DS and AD...
July 6, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28719742/integrated-smartphone-app-chip-system-for-on-site-ppb-level-colorimetric-quantitation-of-aflatoxins
#12
Xiaochun Li, Fan Yang, Jessica X H Wong, Hua-Zhong Yu
We demonstrate herein an integrated, smartphone-app-chip (SPAC) system for on-site quantitation of food toxins, as demonstrated with aflatoxin B1 (AFB1), at parts-per-billion (ppb) level in food products. The detection is based on an indirect competitive immunoassay fabricated on a transparent plastic chip with the assistance of a microfluidic channel plate. A 3D-printed optical accessory attached to a smartphone is adapted to align the assay chip and to provide uniform illumination for imaging, with which high-quality images of the assay chip are captured by the smartphone camera and directly processed using a custom-developed Android app...
July 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28719494/hockey-fans-in-training-a-pilot-pragmatic-randomized-controlled-trial
#13
Robert J Petrella, Dawn P Gill, Guangyong Zou, Ashleigh De Cruz, Brendan Riggin, Cassandra Bartol, Karen Danylchuk, Kate Hunt, Sally Wyke, Cindy M Gray, Christopher Bunn, Merrick Zwarenstein
INTRODUCTION: Hockey Fans in Training (Hockey FIT) is a gender-sensitized weight loss and healthy lifestyle program. We investigated: 1) feasibility of recruiting and retaining overweight and obese men into a pilot pragmatic randomized controlled trial; and 2) potential for Hockey FIT to lead to weight loss and improvements in other outcomes at 12 weeks and 12 months. METHODS: Male fans of 2 ice hockey teams (35-65 years; body-mass index ≥28 kg/m) located in Ontario (Canada) were randomized to intervention (Hockey FIT) or comparator (Wait-list Control)...
July 17, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28719493/validity-and-reliability-of-assessing-body-composition-using-a-mobile-application
#14
Elizabeth Z MacDonald, Pat R Vehrs, Gilbert W Fellingham, Dennis Eggett, James D George, Ronald Hager
PURPOSE: The purpose of this study was to determine the validity and reliability of the LeanScreen (LS) mobile application that estimates percent body fat (%BF) using estimates of circumferences from photographs. METHODS: The %BF of 148 weight-stable adults was estimated once using DXA. Each of two administrators assessed the %BF of each subject twice using the LS app and manually measured circumferences. A mixed model ANOVA and Bland-Altman analyses were used to compare the estimates of %BF obtained from each method...
July 17, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28718223/self-management-of-stress-urinary-incontinence-via-a-mobile-app-2-year-follow-up-of-a-randomized-controlled-trial
#15
Victoria Hoffman, Lars Söderström, Eva Samuelsson
We investigated the long-term effects of using a mobile app to treat stress urinary incontinence with a focus on pelvic floor muscle training (PFMT) MATERIAL AND METHODS: A previous randomized controlled trial of 123 women aged 27-72 years found that 3 months of self-managing stress urinary incontinence with support from the Tät(®) app was effective. We followed-up the women in the app group (n=62) two years after the initial trial with the same primary outcomes for symptom severity (International Consultation on Incontinence Questionnaire Short Form [ICIQ-UI SF]) and condition-specific quality of life (ICIQ-Lower Urinary Tract Symptom Quality of Life [ICIQ-LUTSqol]) and compared the scores with those at baseline RESULTS: Of the 62 women, 61 and 46 (75...
July 17, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28717569/histogram-analysis-for-smartphone-based-rapid-hematocrit-determination
#16
Uddin M Jalal, Sang C Kim, Joon S Shim
A novel and rapid analysis technique using histogram has been proposed for the colorimetric quantification of blood hematocrits. A smartphone-based "Histogram" app for the detection of hematocrits has been developed integrating the smartphone embedded camera with a microfluidic chip via a custom-made optical platform. The developed histogram analysis shows its effectiveness in the automatic detection of sample channel including auto-calibration and can analyze the single-channel as well as multi-channel images...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28715792/smartphone-based-cyclic-voltammetry-system-with-graphene-modified-screen-printed-electrodes-for-glucose-detection
#17
Daizong Ji, Lei Liu, Shuang Li, Chen Chen, Yanli Lu, Jiajia Wu, Qingjun Liu
Smartphone-based electrochemical devices have such advantages as the low price, miniaturization, and obtaining the real-time data. As a popular electrochemical method, cyclic voltammetry (CV) has shown its great practicability for quantitative detection and electrodes modification. In this study, a smartphone-based CV system with a simple method of electrode modification was constructed to perform electrochemical detections. The system was composed of these main portions: modified electrodes, portable electrochemical detector and smartphone...
July 11, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28715617/ionophore-based-anion-selective-optode-printed-on-cellulose-paper
#18
Xuewei Wang, Qi Zhang, Changwoo Nam, Michael Hickner, Mollie Mahoney, Mark Meyerhoff
We report a general anion sensing platform based on a portable and cost-effective ion-selective optode and a smartphone detector equipped with a color analysis app. In contrast to traditional anion-selective optodes using a hydrophobic polymer and/or plasticizer to dissolve hydrophobic sensing elements, the new optode relies on hydrophilic cellulose paper. The anion ionophore and a lipophilic pH indicator are inkjet-printed and adsorbed on paper and form a "dry" hydrophobic sensing layer. Porous cellulose sheets also allow the sensing site to be modified with dried buffer that prevents any sample pH dependence of the observed color change...
July 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28714389/a-peptide-based-pro-drug-ameliorates-amyloid-%C3%AE-induced-neuronal-apoptosis-in-in-vitro-sh-sy5y-cells
#19
Sourav Kumar, Ashim Paul, Sourav Kalita, Awanish Kumar, Saurabh Srivastav, Somoday Hazra, Anup Kumar Ghosh, Bhubaneswar Mandal, Amal Chandra Mondal
BACKGROUND: Alzheimer's disease (AD), a common protein misfolding neurodegenerative disorder, is one of the most common forms of dementia. Amyloid precursor protein (APP) derived amyloid-β (Aβ) proteins accumulated into interneuronal spaces and plays a crucial role in the disease progression and its pathology. The aggregated Aβ exerts its neurotoxic effects by inducing apoptosis and oxidative damage in neuronal cells. OBJECTIVES: We have investigated the effects of a synthesized Pro-Drug peptide (PDp) on Aβ1-40 induced cytotoxicity in human neuroblastoma SH-SY5Y cells, represents one of the most effective strategies in combating human AD...
July 13, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28713250/impaired-in-vivo-gamma-oscillations-in-the-medial-entorhinal-cortex-of-knock-in-alzheimer-model
#20
Tomoaki Nakazono, Travis N Lam, Ayushi Y Patel, Masashi Kitazawa, Takashi Saito, Takaomi C Saido, Kei M Igarashi
The entorhinal cortex (EC) has bidirectional connections with the hippocampus and plays a critical role in memory formation and retrieval. EC is one of the most vulnerable regions in the brain in early stages of Alzheimer's disease (AD), a neurodegenerative disease with progressive memory impairments. Accumulating evidence from healthy behaving animals indicates gamma oscillations (30-100 Hz) as critical for mediating interactions in the circuit between EC and hippocampus. However, it is still unclear whether gamma oscillations have causal relationship with memory impairment in AD...
2017: Frontiers in Systems Neuroscience
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