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https://www.readbyqxmd.com/read/28239698/beneficial-effects-of-apple-peel-polyphenols-on-vascular-endothelial-dysfunction-and-liver-injury-in-high-choline-fed-mice
#1
Mengfan Jia, Daoyuan Ren, Yan Nie, Xingbin Yang
This study was designed to investigate the preventive effects of Red Fuji apple peel polyphenolic extract (APP) on vascular endothelial dysfunction and liver injury in mice fed a high choline diet. The mice were fed 3% dietary choline in drinking water for 8 weeks and displayed vascular dysfunction and liver damage (p < 0.01). The administration of APP at 600 and 900 mg per kg bw significantly elevated serum NO, HDL and 6-Keto-PGF1a levels and lowered serum TC, TG, LDL, ET-1 and TXB2 levels in the HC-fed mice...
February 27, 2017: Food & Function
https://www.readbyqxmd.com/read/28238167/effects-of-cox1-2-5-lox-blockade-in-alzheimer-transgenic-3xtg-ad-mice
#2
Alessandra Bitto, Daniela Giuliani, Giovanni Pallio, Natasha Irrera, Eleonora Vandini, Fabrizio Canalini, Davide Zaffe, Alessandra Ottani, Letteria Minutoli, Mariagrazia Rinaldi, Salvatore Guarini, Francesco Squadrito, Domenica Altavilla
OBJECTIVE AND DESIGN: Alzheimer's disease (AD) is associated with amyloid plaques (Aβ) and hyperphosphorylated tau protein tangles in the brain. We investigated the possible neuroprotective role of flavocoxid, a dual inhibitor of cyclooxygenases-1/2 (COX-1/2) and 5-Lipoxygenase (5-LOX), in triple-transgenic (3xTg-AD) mice. SUBJECTS: Mice were 3 months at the beginning of the study. TREATMENT: Animals received once daily for 3-month saline solution or flavocoxid (20 mg/kg/ip)...
February 25, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28237964/vulnerability-to-oxygen-glucose-deprivation-of-primary-neurons-derived-from-tg2576-alzheimer-mice-role-of-intraneuronal-abeta-accumulation-and-astrocytes
#3
Vito Antonio Baldassarro, Alessandra Marchesini, Luciana Giardino, Laura Calzà
Microvascular dysfunction is considered an integral part of Alzheimer disease (AD) pathogenesis, but the possible relationship between amyloid pathology, microvascular dysfunction and cell death is still unclear. In order to investigate the influence of intraneuronal Abeta (Aβ) accumulation on vulnerability to hypoxia, we isolated primary cortical neurons from Tg2576 (carrying the APPSwe mutation) and Wt fetal mice. We first demonstrated that neurons isolated from Tg2576 new-born mice show an increase in VEGFa mRNA expression and a decrease in the expression of the two VEGF receptors, i...
February 24, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28237071/exploring-the-needs-of-certified-hand-therapists-regarding-electronic-applications
#4
Nathan Short, James LaRowe, T'Neill Treherne, Olivia Francis, Christopher Garau, Michael Schutt, Chun Yu Wei
STUDY DESIGN: Survey. INTRODUCTION: App technology may provide a beneficial clinical resource for CHTs. PURPOSE OF STUDY: This descriptive study examined beneficial components for inclusion in a potential app for certified hand therapists to use as a clinical resource based on a nationwide survey. METHODS: Certified hand therapist members of the American Society of Hand Therapists were surveyed to evaluate preferences of content to be included in a potential clinical app...
February 22, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28236288/self-management-and-shared-decision-making-in-alcohol-dependence-via-a-mobile-app-a-pilot-study
#5
Pablo Barrio, Lluisa Ortega, Hugo López, Antoni Gual
PURPOSE: Mobile applications (apps) have created new opportunities in the field of alcohol dependence (AD) within new paradigms of shared decision-making and self-management. The aim of this study is to report the results of a pilot study testing the usability of and satisfaction with a mobile app (called SIDEAL) in AD patients. METHODS: Adult AD outpatients were included. SIDEAL was installed on patients' personal phones. The Timeline Followback (TLFB) method for the preceding 6 weeks was administered both at baseline and after 6 weeks (end of the study)...
February 24, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28235944/ten-minute-chat
#6
Peter Hastie, Jo-Anne Murray
Peter Hastie and Jo-Anne Murray have developed an app called 'Be a vet' to help anyone who is considering a career in veterinary medicine to decide whether it is right for them.
February 25, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28235940/app-based-veterinary-service
#7
(no author information available yet)
No abstract text is available yet for this article.
February 25, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28228739/touchscreen-tablets-coordinating-action-and-perception-for-mathematical-cognition
#8
Carolien A C G Duijzer, Shakila Shayan, Arthur Bakker, Marieke F Van der Schaaf, Dor Abrahamson
Proportional reasoning is important and yet difficult for many students, who often use additive strategies, where multiplicative strategies are better suited. In our research we explore the potential of an interactive touchscreen tablet application to promote proportional reasoning by creating conditions that steer students toward multiplicative strategies. The design of this application (Mathematical Imagery Trainer) was inspired by arguments from embodied-cognition theory that mathematical understanding is grounded in sensorimotor schemes...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28228716/intranasal-bmp9-ameliorates-alzheimer-disease-like-pathology-and-cognitive-deficits-in-app-ps1-transgenic-mice
#9
Zigao Wang, Lu Xiong, Wenbin Wan, Lijie Duan, Xiaojing Bai, Hengbing Zu
Alzheimer's disease (AD) is the most common type of dementia and has no effective therapies. Previous studies showed that bone morphogenetic protein 9 (BMP9), an important factor in the differentiation and phenotype maintenance of cholinergic neurons, ameliorated the cholinergic defects resulting from amyloid deposition. These findings suggest that BMP9 has potential as a therapeutic agent for AD. However, the effects of BMP9 on cognitive function in AD and its underlying mechanisms remain elusive. In the present study, BMP9 was delivered intranasally to 7-month-old APP/PS1 mice for 4 weeks...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28228519/live-cell-imaging-reveals-tau-isoforms-imbalance-disrupts-traffic-of-app-vesicles-in-human-neurons
#10
Christy Oi Ying Hung
No abstract text is available yet for this article.
February 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28228369/feasibility-of-implementing-a-patient-centered-postoperative-wound-monitoring-program-using-smartphone-images-a-pilot-protocol
#11
Sara Fernandes-Taylor, Rebecca L Gunter, Kyla M Bennett, Lola Awoyinka, Shahrose Rahman, Caprice C Greenberg, K Craig Kent
BACKGROUND: Surgical site infections (SSI) represent a significant public health problem as the most common nosocomial infection and a leading cause of unplanned hospital readmissions among surgical patients. Many develop following hospital discharge and often go unrecognized by patients. Telemedicine offers the opportunity to leverage the mobile technology to remotely monitor wound recovery in the transitional period between hospital discharge and routine clinic follow-up. However, many existing telemedicine platforms are episodic, replacing routine follow-up, rather than equipped for continued monitoring; they include only low-risk patient populations and those who already have access to and comfort with the necessary technology; and transmit no visual information...
February 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28228099/impact-of-adding-additional-providers-to-resident-workload-and-the-resident-experience-on-a-medical-consultation-rotation
#12
Michele Fang, Eric Linson, Manish Suneja, Ethan F Kuperman
BACKGROUND: Excellence in Graduate Medical Education requires the right clinical environment with an appropriate workload where residents have enough patients to gain proficiency in medicine with optimal time for reflection. The Accreditation Council for Graduate Medical Education (ACGME) has focused more on work hours rather than workload; however, high resident workload has been associated with lower resident participation in education and fatigue-related errors. Recognizing the potential risks associated with high resident workload and being mindful of the costs of reducing resident workload, we sought to reduce residents' workload by adding an advanced practice provider (APP) to the surgical comanagement service (SCM) and study its effect on resident satisfaction and perceived educational value of the rotation...
February 22, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28227828/pose-measurement-of-anterior-pelvic-plane-based-on-inertial-measurement-unit-in-total-hip-replacement-surgeries
#13
Zhe Cao, Shaojie Su, Hong Chen, Hao Tang, Yixin Zhou, Zhihua Wang, Zhe Cao, Shaojie Su, Hong Chen, Hao Tang, Yixin Zhou, Zhihua Wang, Zhe Cao, Yixin Zhou, Hong Chen, Zhihua Wang, Hao Tang, Shaojie Su
In Total Hip Replacement (THR), inaccurate measurement of Anterior Pelvic Plane (APP), which is usually used as a reference plane, will lead to malposition of the acetabular prosthesis. As a result, the risk of impingement, dislocation and wear will increase and the safe range of motion will be limited. In order to acquire the accurate pose of APP, a measurement system is designed in this paper, which includes two parts: one is used to estimate the initial pose of APP and the other is used to trail dynamic motion of APP...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227482/assessing-app-quality-through-expert-peer-review-a-case-study-from-the-gray-matters-study
#14
Phillip J Hartin, Ian Cleland, Chris D Nugent, Sally I McClean, JoAnn Tschanz, Christine Clark, Maria C Norton, Phillip J Hartin, Ian Cleland, Chris D Nugent, Sally I McClean, JoAnn Tschanz, Christine Clark, Maria C Norton, JoAnn Tschanz, Christine Clark, Ian Cleland, Maria C Norton, Sally I McClean, Chris D Nugent, Phillip J Hartin
Health apps focused on inciting behavior change are becoming increasingly popular. Nevertheless, many lack underlying evidence base, scientific credibility and have limited clinical effectiveness. It is therefore important that apps are well-informed, scientifically credible, peer reviewed and evidence based. This paper presents the use of the Mobile App Rating Scale (MARS) to assess the quality of the Grey Matters app, a cross platform app to deliver health education material and track behavior change across multi-domains with the aim of reducing the risk of developing Alzheimer's disease...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227217/acceptability-of-a-team-based-mobile-health-mhealth-application-for-lifestyle-self-management-in-individuals-with-chronic-illnesses
#15
Andrea L Hartzler, Anusha Venkatakrishnan, Shiwali Mohan, Michael Silva, Paula Lozano, James D Ralston, Evette Ludman, Dori Rosenberg, Katherine M Newton, Lester Nelson, Peter Pirolli, Andrea L Hartzler, Anusha Venkatakrishnan, Shiwali Mohan, Michael Silva, Paula Lozano, James D Ralston, Evette Ludman, Dori Rosenberg, Katherine M Newton, Lester Nelson, Peter Pirolli, Dori Rosenberg, James D Ralston, Evette Ludman, Katherine M Newton, Lester Nelson, Anusha Venkatakrishnan, Shiwali Mohan, Michael Silva, Paula Lozano, Peter Pirolli, Andrea L Hartzler
With increased incidence of chronic illnesses arising due to unhealthy lifestyle habits, it is increasingly important to leverage technology applications to promote and sustain health behavior change. We developed a smartphone-based application, NutriWalking (NW), which recommends personalized daily exercise goals and promotes healthy nutritional habits in small peer teams. Here, we demonstrate an early study of usability and acceptability of this app in patients with type 2 Diabetes Mellitus and Depression...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227048/anticoagulation-manager-development-of-a-clinical-decision-support-mobile-application-for-management-of-anticoagulants
#16
Chih-Wen Cheng, Hang Wu, Pamela J Thompson, Julie R Taylor, Barbara A Zehnbauer, Karlyn K Wilson, May D Wang, Chih-Wen Cheng, Hang Wu, Pamela J Thompson, Julie R Taylor, Barbara A Zehnbauer, Karlyn K Wilson, May D Wang, Karlyn K Wilson, Pamela J Thompson, Barbara A Zehnbauer, Hang Wu, Julie R Taylor, Chih-Wen Cheng, May D Wang
Patients with certain clotting disorders or conditions have a greater risk of developing arterial or venous clots and downstream embolisms, strokes, and arterial insufficiency. These patients need prescription anticoagulant drugs to reduce the possibility of clot formation. However, historically, the clinical decision making workflow in determining the correct type and dosage of anticoagulant(s) is part science and part art. To address this problem, we developed Anticoagulation Manager, an intelligent clinical decision workflow management system on iOS-based mobile devices to help clinicians effectively choose the most appropriate and helpful follow-up clotting tests for patients with a common clotting profile...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227046/design-and-development-of-an-aac-app-based-on-a-speech-to-symbol-technology
#17
Elena Radici, Stefano Bonacina, Gianluca De Leo, Elena Radici, Stefano Bonacina, Gianluca De Leo, Gianluca De Leo, Stefano Bonacina, Elena Radici
The purpose of this paper is to present the design and the development of an Augmentative and Alternative Communication app that uses a speech to symbol technology to model language, i.e. to recognize the speech and display the text or the graphic content related to it. Our app is intended to be adopted by communication partners who want to engage in interventions focused on improving communication skills. Our app has the goal of translating simple speech sentences in a set of symbols that are understandable by children with complex communication needs...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227039/amp-a-platform-for-managing-and-mining-data-in-the-treatment-of-autism-spectrum-disorder
#18
Erik Linstead, Ryan Burns, Duy Nguyen, David Tyler, Erik Linstead, Ryan Burns, Duy Nguyen, David Tyler, Erik Linstead, Duy Nguyen, Ryan Burns, David Tyler
We introduce AMP (Autism Management Platform), an integrated health care information system for capturing, analyzing, and managing data associated with the diagnosis and treatment of Autism Spectrum Disorder in children. AMP's mobile application simplifies the means by which parents, guardians, and clinicians can collect and share multimedia data with one another, facilitating communication and reducing data redundancy, while simplifying retrieval. Additionally, AMP provides an intelligent web interface and analytics platform which allow physicians and specialists to aggregate and mine patient data in real-time, as well as give relevant feedback to automatically learn data filtering preferences over time...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226570/a-wearable-signal-acquisition-system-for-physiological-signs-including-throat-ppg
#19
Yizhou Zhong, Yun Pan, Ling Zhang, Kwang-Ting Cheng, Yizhou Zhong, Yun Pan, Ling Zhang, Kwang-Ting Cheng, Yizhou Zhong, Ling Zhang, Kwang-Ting Cheng, Yun Pan
This paper presents a wearable signal acquisition system, which can measure physiological signs, i.e., electrocardiogram (ECG) and photoplethysmogram (PPG). The system is comprised of two parts: (1) an ECG sensor implemented in the master board which will be mounted on the chest and, (2) a combined PPG and motion sensor implemented in the slave board which will be worn around the neck area. The single-lead ECG, the single-channel PPG, and the 3-channel accelerometer signals are all sampled at 200Hz, and transmitted to an Android app through Bluetooth® low energy (BLE) in real time...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226549/an-ict-and-mobile-health-integrated-approach-to-optimize-patients-education-on-hypertension-and-its-management-by-physicians-the-patients-optimal-strategy-of-treatment-post-pilot-study
#20
Fabio Albini, Xiaoqiu Liu, Camilla Torlasco, Davide Soranna, Andrea Faini, Renata Ciminaghi, Ada Celsi, Matteo Benedetti, Antonella Zambon, Marco di Rienzo, Gianfranco Parati, Fabio Albini, Xiaoqiu Liu, Camilla Torlasco, Davide Soranna, Andrea Faini, Renata Ciminaghi, Ada Celsi, Matteo Benedetti, Antonella Zambon, Marco di Rienzo, Gianfranco Parati, Renata Ciminaghi, Marco di Rienzo, Davide Soranna, Ada Celsi, Gianfranco Parati, Fabio Albini, Antonella Zambon, Xiaoqiu Liu, Andrea Faini, Camilla Torlasco, Matteo Benedetti
INTRODUCTION: Uncontrolled hypertension is largely attributed to unsatisfactory doctor's engagement in its optimal management and to poor patients' compliance to therapeutic interventions. ICT and mobile Health solutions might improve these conditions, being widely available and providing highly effective communication strategies. OBJECTIVE: To evaluate whether ICT and mobile Health tools are able to improve hypertension control by improving doctors' engagement and by increasing patients' education and involvement, and their compliance to lifestyle modification and prescribed drug therapy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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