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https://www.readbyqxmd.com/read/27933404/genome-wide-high-content-sirna-screening-identifies-the-alzheimer-s-genetic-risk-factor-fermt2-as-a-major-modulator-of-app-metabolism
#1
Julien Chapuis, Amandine Flaig, Benjamin Grenier-Boley, Fanny Eysert, Virginie Pottiez, Gaspard Deloison, Alexandre Vandeputte, Anne-Marie Ayral, Tiago Mendes, Shruti Desai, Alison M Goate, John S K Kauwe, Florence Leroux, Adrien Herledan, Florie Demiautte, Charlotte Bauer, Fréderic Checler, Ronald C Petersen, Kaj Blennow, Henrik Zetterberg, Lennart Minthon, Vivianna M Van Deerlin, Virginia Man-Yee Lee, Leslie M Shaw, John Q Trojanowski, Marilyn Albert, Abhay Moghekar, Richard O'Brien, Elaine R Peskind, Nicolas Malmanche, Gerard D Schellenberg, Pierre Dourlen, Ok-Ryul Song, Carlos Cruchaga, Philippe Amouyel, Benoit Deprez, Priscille Brodin, Jean-Charles Lambert
Genome-wide association studies (GWASs) have identified 19 susceptibility loci for Alzheimer's disease (AD). However, understanding how these genes are involved in the pathophysiology of AD is one of the main challenges of the "post-GWAS" era. At least 123 genes are located within the 19 susceptibility loci; hence, a conventional approach (studying the genes one by one) would not be time- and cost-effective. We therefore developed a genome-wide, high-content siRNA screening approach and used it to assess the functional impact of gene under-expression on APP metabolism...
December 8, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27933006/system-to-detect-racial-based-bullying-through-gamification
#2
José A Álvarez-Bermejo, Luis J Belmonte-Ureña, Africa Martos-Martínez, Ana B Barragán-Martín, María Del Mar Simón-Marquez
Prevention and detection of bullying due to racial stigma was studied in school contexts using a system designed following "gamification" principles and integrating less usual elements, such as social interaction, augmented reality and cell phones in educational scenarios. "Grounded Theory" and "User Centered Design" were employed to explore coexistence inside and outside the classroom in terms of preferences and distrust in several areas of action and social frameworks of activity, and to direct the development of a cell phone app for early detection of school bullying scenarios...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27932977/human-neural-stem-cell-transplantation-rescues-cognitive-defects-in-app-ps1-model-of-alzheimer-s-disease-by-enhancing-neuronal-connectivity-and-metabolic-activity
#3
Xueyuan Li, Hua Zhu, Xicai Sun, Fuxing Zuo, Jianfeng Lei, Zhanjing Wang, Xinjie Bao, Renzhi Wang
Alzheimer's disease (AD), the most frequent type of dementia, is featured by Aβ pathology, neural degeneration and cognitive decline. To date, there is no cure for this disease. Neural stem cell (NSC) transplantation provides new promise for treating AD. Many studies report that intra-hippocampal transplantation of murine NSCs improved cognition in rodents with AD by alleviating neurodegeneration via neuronal complement or replacement. However, few reports examined the potential of human NSC transplantation for AD...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27932950/amyloid-precursor-proteins-are-dynamically-trafficked-and-processed-during-neuronal-development
#4
Jenna M Ramaker, Robert S Cargill, Tracy L Swanson, Hanil Quirindongo, Marlène Cassar, Doris Kretzschmar, Philip F Copenhaver
Proteolytic processing of the Amyloid Precursor Protein (APP) produces beta-amyloid (Aβ) peptide fragments that accumulate in Alzheimer's Disease (AD), but APP may also regulate multiple aspects of neuronal development, albeit via mechanisms that are not well understood. APP is a member of a family of transmembrane glycoproteins expressed by all higher organisms, including two mammalian orthologs (APLP1 and APLP2) that have complicated investigations into the specific activities of APP. By comparison, insects express only a single APP-related protein (APP-Like, or APPL) that contains the same protein interaction domains identified in APP...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27932736/app-for-access-to-medicines-compendium
#5
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27932315/design-and-testing-of-the-safety-agenda-mobile-app-for-managing-health-care-managers-patient-safety-responsibilities
#6
José Joaquín Mira, Irene Carrillo, Cesar Fernandez, Maria Asuncion Vicente, Mercedes Guilabert
BACKGROUND: Adverse events are a reality in clinical practice. Reducing the prevalence of preventable adverse events by stemming their causes requires health managers' engagement. OBJECTIVE: The objective of our study was to develop an app for mobile phones and tablets that would provide managers with an overview of their responsibilities in matters of patient safety and would help them manage interventions that are expected to be carried out throughout the year...
December 8, 2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27932009/mobile-marketing-to-children-a-content-analysis-of-food-and-beverage-company-apps
#7
L B Hurwitz, E D Morales, H Montague, A R Lauricella, E Wartella
No abstract text is available yet for this article.
December 2016: Public Health
https://www.readbyqxmd.com/read/27930341/analysis-of-138-pathogenic-mutations-in-presenilin-1-on-the-in-vitro-production-of-a%C3%AE-42-and-a%C3%AE-40-peptides-by-%C3%AE-secretase
#8
Linfeng Sun, Rui Zhou, Guanghui Yang, Yigong Shi
A hallmark of Alzheimer's disease (AD) is the aggregation of β-amyloid peptides (Aβ) into amyloid plaques in patient brain. Cleavage of amyloid precursor protein (APP) by the intramembrane protease γ-secretase produces Aβ of varying lengths, of which longer peptides such as Aβ42 are thought to be more harmful. Increased ratios of longer Aβs over shorter ones, exemplified by the ratio of Aβ42 over Aβ40, may lead to formation of amyloid plaques and consequent development of AD. In this study, we analyzed 138 reported mutations in human presenilin-1 (PS1) by individually reconstituting the mutant PS1 proteins into anterior-pharynx-defective protein 1 (APH-1)aL-containing γ-secretases and examining their abilities to produce Aβ42 and Aβ40 in vitro...
December 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27929541/non-amyloidogenic-effects-of-%C3%AE-2-adrenergic-agonists-implications-for-brimonidine-mediated-neuroprotection
#9
Shereen Nizari, Li Guo, Benjamin M Davis, Eduardo M Normando, Joana Galvao, Lisa A Turner, Mukhtar Bizrah, Mohammad Dehabadi, Kailin Tian, M Francesca Cordeiro
The amyloid beta (Aβ) pathway is strongly implicated in neurodegenerative conditions such as Alzheimer's disease and more recently, glaucoma. Here, we identify the α2 adrenergic receptor agonists (α2ARA) used to lower intraocular pressure can prevent retinal ganglion cell (RGC) death via the non-amyloidogenic Aβ-pathway. Neuroprotective effects were confirmed in vivo and in vitro in different glaucoma-related models using α2ARAs brimonidine (BMD), clonidine (Clo) and dexmedetomidine. α2ARA treatment significantly reduced RGC apoptosis in experimental-glaucoma models by 97...
December 8, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27928747/interface-a-software-package-for-face-image-warping-averaging-and-principal-components-analysis
#10
Robin S S Kramer, Rob Jenkins, A Mike Burton
We describe InterFace, a software package for research in face recognition. The package supports image warping, reshaping, averaging of multiple face images, and morphing between faces. It also supports principal components analysis (PCA) of face images, along with tools for exploring the "face space" produced by PCA. The package uses a simple graphical user interface, allowing users to perform these sophisticated image manipulations without any need for programming knowledge. The program is available for download in the form of an app, which requires that users also have access to the (freely available) MATLAB Runtime environment...
December 7, 2016: Behavior Research Methods
https://www.readbyqxmd.com/read/27927802/expression-and-processing-of-amyloid-precursor-protein-in-vascular-endothelium
#11
REVIEW
Livius V d'Uscio, Tongrong He, Zvonimir S Katusic
Amyloid precursor protein (APP) is evolutionary conserved protein expressed in endothelial cells of cerebral and peripheral arteries. In this review, we discuss mechanisms responsible for expression and proteolytic cleavage of APP in endothelial cells. We focus on physiological and pathological implications of APP expression in vascular endothelium.
January 2017: Physiology
https://www.readbyqxmd.com/read/27927218/efficacy-of-interventions-that-use-apps-to-improve-diet-physical-activity-and-sedentary-behaviour-a-systematic-review
#12
REVIEW
Stephanie Schoeppe, Stephanie Alley, Wendy Van Lippevelde, Nicola A Bray, Susan L Williams, Mitch J Duncan, Corneel Vandelanotte
BACKGROUND: Health and fitness applications (apps) have gained popularity in interventions to improve diet, physical activity and sedentary behaviours but their efficacy is unclear. This systematic review examined the efficacy of interventions that use apps to improve diet, physical activity and sedentary behaviour in children and adults. METHODS: Systematic literature searches were conducted in five databases to identify papers published between 2006 and 2016. Studies were included if they used a smartphone app in an intervention to improve diet, physical activity and/or sedentary behaviour for prevention...
December 7, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27926892/do-mobile-phone-applications-improve-glycemic-control-hba1c-in-the-self-management-of-diabetes-a-systematic-review-meta-analysis-and-grade-of-14-randomized-trials
#13
REVIEW
Can Hou, Ben Carter, Jonathan Hewitt, Trevor Francisa, Sharon Mayor
OBJECTIVE: To investigate the effect of mobile phone applications (apps) on glycemic control (HbA1c) in the self-management of diabetes. RESEARCH DESIGN AND METHODS: Relevant studies that were published between 1 January 1996 and 1 June 2015 were searched from five databases: Medline, CINAHL, Cochrane Library, Web of Science, and Embase. Randomized controlled trials that evaluated diabetes apps were included. We conducted a systematic review with meta-analysis and GRADE (Grading of Recommendations Assessment, Development and Evaluation) of the evidence...
November 2016: Diabetes Care
https://www.readbyqxmd.com/read/27925790/acids-bases-and-apps-primum-non-nocere
#14
Trevor T Nicholson, Thomas C Corbridge
No abstract text is available yet for this article.
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27924525/a-three-day-consecutive-fingolimod-administration-improves-neurological-functions-and-modulates-multiple-immune-responses-of-cci-mice
#15
Chuang Gao, Yu Qian, Jinhao Huang, Dong Wang, Wanqiang Su, Peng Wang, Linyue Guo, Wei Quan, Shuo An, Jianning Zhang, Rongcai Jiang
Excessive inflammation after traumatic brain injury (TBI) is a major cause of secondary TBI. Though several inflammatory biomarkers have been postulated as the risk factors of TBI, there has not been any comprehensive description of them. Fingolimod, a new kind of immunomodulatory agent which can diminish various kinds of inflammatory responses, has shown additional therapeutic effects in the treatment of intracranial cerebral hematoma (ICH), ischemia, spinal cord injury (SCI), and many other CNS disorders...
December 6, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27924346/bpcontrol-a-mobile-app-to-monitor-hypertensive-patients
#16
Adrian Carrera, Marc Pifarré, Jordi Vilaplana, Josep Cuadrado, Sara Solsona, Jordi Mateo, Francesc Solsona
BACKGROUND: Hypertension or high blood pressure is on the rise. Not only does it affect the elderly but is also increasingly spreading to younger sectors of the population. Treating this condition involves exhaustive monitoring of patients. The current mobile health services can be improved to perform this task more effectively. OBJECTIVE: To develop a useful, user-friendly, robust and efficient app, to monitor hypertensive patients and adapted to the particular requirements of hypertension...
December 7, 2016: Applied Clinical Informatics
https://www.readbyqxmd.com/read/27924018/disgenet-a-comprehensive-platform-integrating-information-on-human-disease-associated-genes-and-variants
#17
Janet Piñero, Àlex Bravo, Núria Queralt-Rosinach, Alba Gutiérrez-Sacristán, Jordi Deu-Pons, Emilio Centeno, Javier García-García, Ferran Sanz, Laura I Furlong
The information about the genetic basis of human diseases lies at the heart of precision medicine and drug discovery. However, to realize its full potential to support these goals, several problems, such as fragmentation, heterogeneity, availability and different conceptualization of the data must be overcome. To provide the community with a resource free of these hurdles, we have developed DisGeNET (http://www.disgenet.org), one of the largest available collections of genes and variants involved in human diseases...
October 19, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923778/influence-of-pok%C3%A3-mon-go-on-physical-activity-study-and-implications
#18
Tim Althoff, Ryen W White, Eric Horvitz
BACKGROUND: Physical activity helps people maintain a healthy weight and reduces the risk for several chronic diseases. Although this knowledge is widely recognized, adults and children in many countries around the world do not get recommended amounts of physical activity. Although many interventions are found to be ineffective at increasing physical activity or reaching inactive populations, there have been anecdotal reports of increased physical activity due to novel mobile games that embed game play in the physical world...
December 6, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27923777/parent-and-clinician-preferences-for-an-asthma-app-to-promote-adolescent-self-management-a-formative-study
#19
Lorie L Geryk, Courtney A Roberts, Adam J Sage, Tamera Coyne-Beasley, Betsy L Sleath, Delesha M Carpenter
BACKGROUND: Most youth asthma apps are not designed with parent and clinician use in mind, and rarely is the app development process informed by parent or clinician input. OBJECTIVE: This study was conducted to generate formative data on the use, attitudes, and preferences for asthma mHealth app features among parents and clinicians, the important stakeholders who support adolescents with asthma and promote adolescent self-management skills. METHODS: We conducted a mixed-methods study from 2013 to 2014 employing a user-centered design philosophy to acquire feedback from a convenience sample of 20 parents and 6 clinicians...
December 6, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27923640/the-accumulation-of-brain-injury-leads-to-severe-neuropathological-and-neurobehavioral-changes-after-repetitive-mild-traumatic-brain-injury
#20
Huabin Gao, Zhaoli Han, Ruojing Bai, Shan Huang, Xintong Ge, Fanglian Chen, Ping Lei
Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of accumulation play an important role in the neurodegenerative disease is still unknown. We utilized the Sprague Dawley (SD) rats to develop the animal models of repetitive mild TBI and single mild TBI in order to detect the neurobehavioral changes...
December 3, 2016: Brain Research
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